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"no evidence of disease activity" OR NEDA

Nicholas Petronella, Jennifer Ronholm, Menka Suresh, Jennifer Harlow, Oksana Mykytczuk, Nathalie Corneau, Sabah Bidawid, Neda Nasheri
BACKGROUND: Human norovirus is the leading cause of viral gastroenteritis globally, and the GII.4 has been the most predominant genotype for decades. This genotype has numerous variants that have caused repeated epidemics worldwide. However, the molecular evolutionary signatures among the GII.4 variants have not been elucidated throughout the viral genome. METHOD: A metagenomic, next-generation sequencing method, based on Illumina RNA-Seq, was applied to determine norovirus sequences from clinical samples...
October 17, 2018: BMC Infectious Diseases
Katharina Kern, Stephan M G Schäfer, Jennifer Cohnen, Sandra Pierre, Tabea Osthues, Neda Tarighi, Stefan Hohmann, Nerea Ferreiros, Bernhard Brüne, Andreas Weigert, Gerd Geisslinger, Marco Sisignano, Klaus Scholich
Macrophages are highly versatile cells, which acquire, depending on their microenvironment, pro- (M1-like), or antiinflammatory (M2-like) phenotypes. Here, we studied the role of the G-protein coupled receptor G2A (GPR132), in chemotactic migration and polarization of macrophages, using the zymosan-model of acute inflammation. G2A-deficient mice showed a reduced zymosan-induced thermal hyperalgesia, which was reversed after macrophage depletion. Fittingly, the number of M1-like macrophages was reduced in the inflamed tissue in G2A-deficient mice...
2018: Frontiers in Immunology
Neda Martinović, Helena Abramovič, Nataša Poklar Ulrih
The efficiencies of sinapic acid and its derivatives syringic acid, syringaldehyde, three sinapoyl esters (ethyl, propyl, butyl sinapates), 4-vinylsyringol and sinapine were investigated for prevention of lipid peroxidation in correlation with their interactions with model lipid membrane systems. Significant antioxidant activities of propyl and butyl sinapates were seen by fluorimetric assay in phosphatidylcholine liposomes as model membrane using C11-BODIPY581/591 lipophilic fluorescent radio-probe. The sinapic acid esters also had the highest impact on membrane structural properties, as observed by differential scanning calorimetry and fluorescence polarisation measurements...
October 13, 2018: Biochimica et biophysica acta. Biomembranes
Farshid Kompani, Ehsan Valavi, Parisa Amuri, Neda Mohtasham
OBJECTIVE: Considering the predictive role of the relatively low urinary citrate for stone formation, especially in hypercalciuric patients, this study is aimed at comparing urine calcium to citrate (Ca/Cit) ratio in 3 groups of children, including patients with idiopathic hypercalciuria with and without renal stone as well as the healthy children. METHODS: This study was carried out on 96 children (2 to 12 years old) referred to a pediatric nephrology clinic in the city of Ahvaz, Southwest Iran...
October 12, 2018: Journal of Renal Nutrition
Maneesh K Misra, Danillo G Augusto, Gonzalo Montero Martin, Neda Nemat-Gorgani, Jürgen Sauter, Jan A Hofmann, James A Traherne, Betsy González-Quezada, Clara Gorodezky, Will Bultitude, Wesley Marin, Cynthia Vierra-Green, Kirsten M Anderson, Antonio Balas, Jose L Caro-Oleas, Elisa Cisneros, Francesco Colucci, Ravi Dandekar, Sally Elfishawi, Marcelo A Fernández-Viña, Merhan Fouda, Rafael González-Fernández, Arend Große, Maria J Herrero-Mata, Sam Q Hollenbach, Steven G Marsh, Alex Mentzer, Derek Middleton, Ashley Moffett, Miguel A Moreno-Hidalgo, Ghada Mossallam, Annettee Nakimuli, Jorge R Oksenberg, Stephen J Oppenheimer, Peter Parham, Maria-Luiza Petzl-Erler, Dolores Planelles, Florentino Sánchez-García, Francisco Sánchez-Gordo, Alexander H Schmidt, John Trowsdale, Luciana B Vargas, Jose L Vicario, Carlos Vilches, Paul J Norman, Jill A Hollenbach
The goals of the KIR component of the 17th International HLA and Immunogenetics Workshop (IHIW) were to encourage and educate researchers to begin analyzing KIR at allelic resolution, and to survey the nature and extent of KIR allelic diversity across human populations. To represent worldwide diversity, we analyzed 1269 individuals from ten populations, focusing on the most polymorphic KIR genes, which express receptors having three immunoglobulin (Ig)-like domains (KIR3DL1/S1, KIR3DL2 and KIR3DL3). We identified 13 novel alleles of KIR3DL1/S1, 13 of KIR3DL2 and 18 of KIR3DL3...
October 12, 2018: Human Immunology
Di Lin, Neda Baktash, Shaif-Ul Alam, David J Richardson
We report the generation of high average output power, high peak power, and high pulse energy radially polarized picosecond pulses from a compact gain-switched laser-diode-seeded Yb-doped fiber master oscillator power amplifier (MOPA) system. A q-plate was employed as a mode converter prior to the final power amplifier to efficiently convert the linearly polarized Gaussian-shaped beam into a donut-shaped radially polarized beam. The desired vector beam was efficiently amplified yielding ∼110  ps pulses with a maximum output pulse energy of ∼30...
October 15, 2018: Optics Letters
Neda Asadi, Robabeh Memarian, Zohreh Vanaki
BACKGROUND: The performance of nurses, which is rooted in personal motivation, determines the quality of care. Therefore, it is important that nurses are motivated to provide high-quality care. PURPOSE: The purpose of this study was to explore the factors that affect caring motivation from the perspectives of nurses in Iran. METHODS: This was a qualitative study. Seventeen nurses were interviewed using a semistructured, in-depth interview method...
October 12, 2018: Journal of Nursing Research: JNR
Neda Motamedi Rad, Meysam Rezaeishahmirzadi, Sepideh Shakeri, Mohamad Reza Abbaszadegan, Mohammad Shekari
Background: Helicobacter pylori are the main cause of chronic inflammation and peptic ulcer. We aimed to determine if IL-1B+ 3954 and IL-1RN polymorphisms are associated with the risk of chronic gastritis and peptic ulcer in Iranian population. Methods: In this case-control study, from 198 individuals enrolled by Mohammadi Hospital, Bandar Abbas, southern Iran from 2012 to 2014 and who showed the symptoms of chronic gastritis and 84 with peptic ulcer participated in the case group, two biopsies were taken from the body, antrum, or ulcer edge of each patient...
September 2018: Iranian Journal of Public Health
Hadi Hassankhani, Amin Soheili, Samad S Vahdati, Farough A Mozaffari, Justin F Fraser, Neda Gilani
STUDY OBJECTIVE: We evaluate the extent and nature of treatment delays and the contributing factors influencing them for patients with acute ischemic stroke, as well as main barriers to stroke care in an Iranian emergency department (ED). METHODS: A retrospective chart review was conducted on 394 patients with acute ischemic stroke who were referred to the ED of a tertiary academic medical center in northwest Iran from March 21 to June 21, 2017. The steps of this review process included instrument development, medical records retrieval, data extraction, and data verification...
October 11, 2018: Annals of Emergency Medicine
Mohsen Emadedin, Narges Labibzadeh, Maede Ghorbani Liastani, Aliasghar Karimi, Neda Jaroughi, Tina Bolurieh, Seyyedeh-Esmat Hosseini, Hossein Baharvand, Nasser Aghdami
BACKGROUND: The intra-articular implantation of mesenchymal stromal cells (MSCs) as a treatment for knee osteoarthritis (OA) is an emerging new therapy. In this study, patients with knee OA received intra-articular implantations of autologous bone marrow-derived MSCs. We sought to assess the safety and efficacy of this implantation. MATERIALS AND METHODS: This was a phase 1/2 single-center, triple-blind, randomized controlled trial (RCT) with a placebo control. The subjects consisted of patients with knee OA randomly assigned to either an intra-articular implantation of MSCs (40 × 106 cells) or 5mL normal saline (placebo)...
October 11, 2018: Cytotherapy
Bagher Farhood, Keywan Mortezaee, Nasser Hashemi Goradel, Neda Khanlarkhani, Ensieh Salehi, Maryam Shabani Nashtaei, Masoud Najafi, Amirhossein Sahebkar
Cancer is the second cause of death worldwide. Chemotherapy and radiotherapy are the most common modalities for the treatment of cancer. Experimental studies have shown that inflammation plays a central role in tumor resistance and the incidence of several side effects following both chemotherapy and radiotherapy. Inflammation resulting from radiotherapy and chemotherapy is responsible for adverse events such as dermatitis, mucositis, pneumonitis, fibrosis, and bone marrow toxicity. Chronic inflammation may also lead to the development of second cancer during years after treatment...
October 14, 2018: Journal of Cellular Physiology
Marta Massanella, Christina Yek, Steven M Lada, Masato Nakazawa, Neda Shefa, Karissa Huang, Douglas D Richman
BACKGROUND: Improved assays are critical to better characterize the HIV reservoir and to reliably evaluate candidate intervention strategies. Here we describe different methods to quantify the HIV reservoir. METHODS: We developed an optimized quantitative viral outgrowth assay (QVOA) to quantify the frequency of cells harboring replication-competent HIV, which is simpler and more sensitive than classical QVOAs. We also developed new inducible RNA assays that concomitantly measure the frequency of cell-associated [ca-] (gag and tat-rev) and cell-free [cf-] HIV RNA after three days of anti-CD3/CD28 stimulation...
October 10, 2018: EBioMedicine
Neda Orakifar, Mohammad Jafar Shaterzadeh-Yazdi, Reza Salehi, Mohammad Mehravar, Neda Namnik
OBJECTIVE: To investigate impairment in the activity pattern of some muscles involved in sit to stand (STD) and stand to sit (STS) among two low back pain (LBP) subgroups of the Movement System Impairment (MSI) model. DESIGN: Case-control study SETTING: A university medical center PARTICIPANTS: Fifteen healthy women and twenty-two women with chronic LBP in two subgroups (fifteen into the lumbar extension rotation (LER) and seven into lumbar flexion rotation (LFR)) voluntarily participated in this study...
October 10, 2018: Archives of Physical Medicine and Rehabilitation
Neda Rashidi, Mohammad Reza Ghorbani, Ahmad Tatar, Somayyeh Salari
This study evaluated the effects of licorice extract and probiotic on performance, excreta characteristics and welfare-related parameters of broiler chickens reared in high stocking density. Three hundred and thirty-six 1-day old broiler chicks (Ross 308) were used in a completely randomized design with five treatments and four replicates for 42 days. Treatments were as follows: (a) positive control (PC, 12 chicks/m2 ); (b) negative control (NC, 18 chicks/m2 ); (c) NC + 500 ppm licorice extract (LE); (d) NC + 200 ppm probiotic (P); (e) NC + ppm LE + ppm P...
October 12, 2018: Journal of Animal Physiology and Animal Nutrition
Eric Simon, Neda Motchurova-Dekova, Bernard Mottequin
The genus Tethyrhynchia Logan in Logan Zibrowius, 1994 is revised on the basis of different methods of analysis including SEM observations, detailed ontogenetic study of the crural development, transverse serial sections, and shell microstructure. Some morphological characters cited in the original diagnosis are analysed and contested by the ontogenetic results. The type of crura of Tethyrhynchia, often placed in the arcual group, appears to be of the raducal group, instead. Paedomorphosis and heterochronic development offer the possibility of opening a dialogue between morphological and phylogenetic approaches to classification of rhynchonellide brachiopods...
September 6, 2018: Zootaxa
Ramin Raoufinia, Sanaz Balkani, Neda Keyhanvar, Behroz Mahdavipor, Jalal Abdolalizadeh
BACKGROUND: Among different proteins of blood, albumin is considered a unique protein due to having special properties. Now, various protocols are used for the albumin purification worldwide, each of them has its own advantages and disadvantages. Meanwhile, a common method which is often used for the production of albumin is a combination of Cohn along with different types of chromatography. The aim of the present study was to create a concise and cost-effective albumin purification method by employing a conventional method with some modifications...
October 12, 2018: Journal of Immunoassay & Immunochemistry
Neda Mostofizadeh, Mahshid Gheidarloo, Mahin Hashemipour, Elham Hashemi Dehkordi
Primordial dwarfism (PD) is a group of rare genetically heterogeneous disorders consisted of disorders with intrauterine growth retardation continued through the life. SOFT syndrome with characteristics of short stature, onychodysplasia, facial dysmorphism, and hypotrichosis has been presented as a subtype of PD. Only 20 cases of SOFT syndrome have been reported in world to date, but none of them were not in Iran. Our case was 6.5-year-old girl with a complaint of growth retardation including height of 97 cm (Z = -4...
2018: Advanced Biomedical Research
Neda Eskandari, Meysam Hassani Moghaddam, Mohammad Ali Atlasi, Javad Amini Mahabadi, Aliakbar Taherian, Hossein Nikzad
Generation of germ cells from embryonic stem cells in vitro could have great application for treating infertility. The temporal expression profile of several genes was expressed at different stages of germ cell development and examined in differentiation the mouse embryonic stem cells. Cells were treated in three groups of control, with 10-8  M of all-trans retinoic acid and the combination of 10-9  M of 17β-Estradiol and retinoic acid for 7, 12, 17 or 22 days. Quantitative RT-PCR and Immunofluorescent were used to investigate the possible inductive effects of estrogen on mouse embryonic stem cell-derived primordial germ cells...
October 8, 2018: Biologicals: Journal of the International Association of Biological Standardization
Mohammad Heidari, Seyedeh Samaneh Miresmaeeli, Neda Eskandary
No abstract text is available yet for this article.
October 11, 2018: Disaster Medicine and Public Health Preparedness
Neda Haghighat, Majid Mohammadshahi, Shokouh Shayanpour, Mohammad Hossein Haghighizadeh
The aim of this study was to investigate the effect of synbiotic and probiotic supplementation on serum vascular dysfunction and necrosis markers in hemodialysis (HD) patients. In this randomized, double-blind, placebo-controlled trial, 75 HD patients were randomly assigned to either the synbiotic or probiotic or placebo group. The patients in the synbiotic group received 15 g of prebiotics and 5 g probiotic powder containing Lactobacillus acidophilus strain T16 (IBRC-M10785), Bifidobacterium bifidum strain BIA-6, Bifidobacterium lactis strain BIA-6, Bifidobacterium longum strain LAF-5 (2...
October 6, 2018: Probiotics and Antimicrobial Proteins
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