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"no evidence of disease activity" OR NEDA

Neda A Moatamed
Urine is a major repository of biometabolites, some proteins, and DNA. Within the past few decades, it has become increasingly apparent that certain infectious, neoplastic, and congenital diseases can be investigated using urine samples for diagnostic and prognostic purposes. In this chapter, a number of pertinent urine analytes and methods of banking urine samples for future analyses are discussed.
2019: Methods in Molecular Biology
Bassem I Yamout, Nabil K El-Ayoubi, Johny Nicolas, Yehya El Kouzi, Samia J Khoury, Maya M Zeineddine
Objective: To evaluate the efficacy and safety of rituximab in multiple sclerosis in a clinical practice setting. Methods: Clinical data for all adult patients with multiple sclerosis (MS) treated with off-label rituximab at a single MS center in Lebanon between March 2008 and April 2017 were retrospectively collected from medical charts. The main efficacy outcomes assessed were annualized relapse rate (ARR) and proportion of patients free from relapses, disability progression, or magnetic resonance imaging (MRI) activity...
2018: Journal of Immunology Research
Christine M Lee, Michelle Moh, Peggy S Sullivan, Neda A Moatamed
Background: BRCA gene mutations significantly increase the risk of breast and ovarian cancers where the lifetime risk of the ovarian cancer is about 40%. Therefore, many women with such mutations undergo prophylactic bilateral mastectomy and salpingo-oophorectomy. About 5-6% of these individuals display occult carcinomas in tubo-ovarian locations of which over 85% are tubal in origin. The objective of this case study was to emphasize emergence of benign lesions mimicking cancer under these circumstances...
2018: Case Reports in Pathology
Neda Kalhor, Cesar A Moran
Eight cases of primary thymic epithelial neoplasms corresponding to seven thymomas and one thymic carcinoma with sebaceous differentiation are presented. The patients are five men and three women between the ages of 45 and 63years (average: 54years) who presented with non-specific symptomatology related to their mediastinal mass. All patients underwent complete surgical resection of the mediastinal mass. Grossly, all the tumors were described as round to oval measuring from 3.5 to 6.0cm in greatest diameter...
December 8, 2018: Human Pathology
Farid Najafi, Jalil Hasani, Neda Izadi, Seyed-Saeed Hashemi-Nazari, Zahra Namvar, Samira Mohammadi, Masoud Sadeghi
This study was conducted to investigate the effect of the prepregnancy BMI on the risk of gestational diabetes mellitus (GDM). Five electronic databases, including PubMed, Scopus, Embase, Web of Science, and Google Scholar, were searched for literature published until 1 January 2018. The two-stage, random effect meta-analysis was performed to compare the dose-response relationship between BMI and GDM. As well as studies with categorized BMI, studies that treat BMI as a continuous variable were analysed. A total of 33 observational studies with an overall sample size of 962 966 women and 42 211 patients with GDM were included in analysis...
December 10, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Amin Talebian-Kiakalaieh, Nor Aishah Saidina Amin, Neda Najaafi, Sara Tarighi
The last 20 years have seen an unprecedented breakthrough in the biodiesel industry worldwide leads to abundance of glycerol. Therefore, the economic utilization of glycerol to various value-added chemicals is vital for the sustainability of the biodiesel industry. One of the promising processes is acetalization of glycerol to acetals and ketals for applications as fuel additives. These products could be obtained by acid-catalyzed reaction of glycerol with aldehydes and ketones. Application of different supported heterogeneous catalysts such as zeolites, heteropoly acids, metal-based and acid-exchange resins have been evaluated comprehensively in this field...
2018: Frontiers in Chemistry
Egle Ragaisyte, Lina Bardauskiene, Egle Zelbiene, Linas Darginavicius, Elzbieta Zemaityte, Nedas Jasinskas, Kestutis Stasaitis
Objectives: The aim of this study was to evaluate the utility of ultrasonographic measurement of the diameter of the inferior vena cava (IVCD) and abdominal aorta (AAD) for assessing volume status. Material and methods: This was a prospective, observational study. A total of 23 volunteers participated in the study. Each participant was selected randomly. All participants completed the 2016 Kaunas Marathon. Participants filed out a brief survey about their fluid intake (in standardised glasses) in the 24 h before the race and during the race...
December 2018: Turkish Journal of Emergency Medicine
Raymond T Doty, Xiaowei Yan, Christopher Lausted, Adam D Munday, Zhantao Yang, Danielle Yi, Neda Jabbari, Li Liu, Siobán B Keel, Qiang Tian, Janis L Abkowitz
Erythropoiesis is the complex, dynamic, and tightly-regulated process that generates all mature red blood cells. To understand this process, we mapped the developmental trajectories of progenitors from wildtype, erythropoietin-treated and Flvcr1 -deleted mice at single cell resolution. Importantly, we linked the quantity of each cell's surface proteins to its total transcriptome, which is a novel method. Deletion of Flvcr1 results in high levels of intracellular heme, allowing us to identify heme-regulated circuitry...
December 10, 2018: Blood
William T Johnson, Reetu Mukherji, Saritha Kartan, Neda Nikbakht, Pierluigi Porcu, Onder Alpdogan
Mycosis fungoides and Sézary syndrome encompass over 70% of all cases of cutaneous T-cell lymphoma (CTCL). While early stage disease has excellent long-term survival rates, advanced stage disease (IIB-IV) carries a poor prognosis with a median 5-year overall survival rate of approximately 50%. Early stage and advanced stage disease have different treatment algorithms with systemic therapy being indicated upfront in the later. The role of allogeneic hematopoietic stem cell transplant (HSCT) has gained considerable interest in recent years as a treatment option for CTCL given the increasingly promising long-term outcomes in an otherwise incurable disease...
October 19, 2018: Chinese Clinical Oncology
Kendra A Young, Amita Maturu, Carlos Lorenzo, Carl D Langefeld, Lynne E Wagenknecht, Yii-Der I Chen, Kent D Taylor, Jerome I Rotter, Jill M Norris, Neda Rasouli
OBJECTIVE: The TG/HDL-C ratio is used as a marker of insulin resistance (IR) in Caucasians; however, there is limited data in other ethnic groups. We hypothesized that the TG/HDL-C ratio is associated with IR in Hispanics and African Americans (AA). RESEARCH DESIGN AND METHODS: Data from the Insulin Resistance Atherosclerosis Family Study was examined for associations between TG/HDL-C ratio and IR, β-cell function and incident diabetes in non-diabetic Hispanics (n = 872, 63% female) and AA (n = 371, 61% female)...
November 3, 2018: Journal of Diabetes and its Complications
Laura Z Hyde, Neda Valizadeh, Ahmed M Al-Mazrou, Ravi P Kiran
OBJECTIVE: Compare the ACS-NSQIP risk calculator with institutional risk for colorectal surgery. METHODS: Actual and predicted outcomes were compared for both cohort and individuals. RESULTS: For the cohort, the risk calculator was accurate for 7/8 outcomes; there were more serious complications than predicted (19.4 vs 14.7%, p < 0.05). Risk calculator Brier scores and null Brier scores were comparable. PATIENTS: with better outcomes than predicted were current smokers (OR 4...
November 28, 2018: American Journal of Surgery
Neda Yaghoubi, Arash Soltani, Kiarash Ghazvini, Seyed Mahdi Hassanian, Seyed Isaac Hashemy
Colorectal cancer (CRC), as a prominent cause of cancer-related deaths, has historically been notable worldwide and many attempts have been made to raise the overall survival of CRC patients. Immune response has long been a question of great interest in a wide range of fields such as cancer therapies and anti-tumor immunity through checkpoint inhibitors, specifically anti PD-1/ PD-L1 interaction, is a new line of research for treatment of CRC patients. Following the successful development of anti-PD-1 for melanoma, renal cell carcinoma, and non-small cell lung cancer, several clinical trials have been conducted on monoclonal antibodies (MAbs) against PD-1 in CRC...
December 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Hamid Reza Mozaffari, Elisa Zavattaro, Abas Abdolahnejad, Pia Lopez-Jornet, Neda Omidpanah, Roohollah Sharifi, Masoud Sadeghi, Mohammad Shooriabi, Mohsen Safaei
Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. The quality of each involved study was done using the Newcastle⁻Ottawa Quality Assessment Scale (NOS) questionnaire...
December 3, 2018: Medicina
Victor M Rivera
Multiple sclerosis (MS) has become a common neurological disorder involving populations previously considered to be infrequently affected. Genetic dissemination from high- to low-risk groups is a determining influence interacting with environmental and epigenetic factors, mostly unidentified. Disease modifying therapies (DMT) are effective in treating relapsing MS in variable degrees; one agent is approved for primary progressive disease, and several are in development. In the era of high-efficacy medications, complex molecules, and monoclonal antibodies (MAB), including anti-VLA4 (natalizumab), anti-CD52 (alemtuzumab), and anti-CD20 (ocrelizumab), obtaining NEDA (no evidence of disease activity) becomes an elusive accomplishment in areas of the world where access to MS therapies and care are generally limited...
November 30, 2018: Biomedicines
M Pisa, P Della Valle, A Coluccia, V Martinelli, G Comi, A D'Angelo, L Moiola
Alemtuzumab is a highly effective monoclonal antibody for the treatment of multiple sclerosis (MS). During the immune reconstitution following the use of this treatment severe secondary autoimmune diseases (SADs) can develop. We present the case of a patient affected by active MS who failed to achieve disease control with several disease-modifying drugs and was thereafter successfully treated with alemtuzumab, obtaining no evidence of disease activity and a high quality of life. Twenty months after the first infusion of alemtuzumab the patient developed acquired haemophilia A (AHA), a treatable but potentially lifethreatening condition that should be considered a possible SADs associated to this drug...
November 29, 2018: Multiple Sclerosis and related Disorders
Mojtaba Mikaniki, Neda Babaee, Ebrahim Mikaniki, Mohammad Reza Hasanjani Roushan, Ali Bijani
Background: Behcet's syndrome is a disease with different aspects in its clinical manifestations. The purpose of this study was to evaluate the simultaneous presence of oral mucosal and ophthalmologic lesions in patients with Behcet's syndrome. Methods: From April 2012 to December 2014, 50 cases of Behcet's syndrome who referred to the Departments of Ophtalmology, Oral Diseases and Infectious Diseases of Babol University Medical Sciences were entered into the study...
2018: Caspian Journal of Internal Medicine
Jelena Jović, Aneta Buntić, Neda Radovanović, Bojan Petrović, Ljiljana Mojović
The aim of this research is to isolate and identify fungi with high lignin-degrading abilities that are autochthonous to southern Serbian region. Two novel fungal isolates identified as Trametes hirsuta F13 and Stereum gausapatum F28 were selected to assess their ligninolytic enzyme activities and the efficiency of lignin removal from beech wood sawdust. Obtained results show that both isolates are good sources of industrially valuable enzymes with a potential for application in various biotechnological and industrial processes...
September 2018: Food Technology and Biotechnology
Jessica L F Teh, Phil F Cheng, Timothy J Purwin, Neda Nikbakht, Prem Patel, Inna Chervoneva, Adam Ertel, Paolo M Fortina, Ines Kleiber, Kim HooKim, Michael A Davies, Lawrence N Kwong, Mitch P Levesque, Reinhard Dummer, Andrew E Aplin
No abstract text is available yet for this article.
December 2018: Cancer Discovery
Kazem Darvish Bastami, Mahmoud Reza Neyestani, Neda Molamohyedin, Elnaz Shafeian, Sara Haghparast, Imam Ali Shirzadi, Mehrnaz Baniamam
We investigated the bioavailability, mobility, and origin of heavy metals present in sediments from the Anzali Wetland. Chemical speciation of the metals was performed according to the Tessier method. Results indicated that Cd and As showed the highest level of bioavailability, whereas Cr showed the lowest level. Cr, Co, and V were shown to have a terrestrial origin. The metal As was mostly found in the reducible fraction (F3), whereas other metals were highest in the residual phase. The levels of Co present in the oxidizable fraction (F4); Pb and Cd present in the carbonate fraction (F2); and the other metals present in the exchangeable fraction (F1) were found to be the lowest...
November 2018: Marine Pollution Bulletin
Mohammad Mehdi Movahedi, Alireza Mehdizadeh, Fereshteh Koosha, Neda Eslahi, Vahid Pirhajati Mahabadi, Habib Ghaznavi, Ali Shakeri-Zadeh
In this article, we report a targeted cancer treatment strategy using nano-photo-thermal therapy (NPTT) and radiotherapy (RT) methods. Gold nanorods (AuNRs) without and with folic acid (FA) conjugation were firstly synthesized and then characterized. Cytotoxicity of various methods; NPTT (nanoparticles; 808 nm laser; 2 W/cm2 ) or RT (6 MV X-ray; 2 Gy) or combination of NPTT and RT; was separately investigated on KB nasopharyngeal carcinoma cells. The effects of different treatments were studies using MTT assay, inductively coupled plasma-mass spectrometry (ICP-MS) and transmission electron microscopy (TEM)...
December 2018: Photodiagnosis and Photodynamic Therapy
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