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"no evidence of disease activity" OR NEDA

Marzieh Najafi, Neda Kordalivand, Mohammad-Amin Moradi, Joep van den Dikkenberg, Remco Fokkink, Heiner Friedrich, Nico A J M Sommerdijk, Mathew Hembury, Tina Vermonden
In this study, native chemical ligation (NCL) was used as a selective crosslinking method to form core-crosslinked thermosensitive polymeric micelles for drug delivery applications. To this end, two complementary ABA triblock copolymers having polyethylene glycol (PEG) as midblock were synthesized by atom transfer radical polymerization (ATRP). The thermosensitive poly isopropyl acrylamide (PNIPAM) outer blocks of the polymers were co-polymerized with either N-(2-hydroxypropyl)methacrylamide-cysteine (HPMA-Cys), P(NIPAM-co-HPMA-Cys)-PEG-P(NIPAM-co-HPMA-Cys) (PNC), or N-(2-hydroxypropyl)methacrylamide-ethylthioglycolate succinic acid (HPMA-ETSA), P(NIPAM-co-HPMA-ETSA)-PEG-P(NIPAM-co-HPMA-ETSA) (PNE)...
August 13, 2018: Biomacromolecules
Monica Marta
The advances in the management of people with multiple sclerosis (pwMS) in past 12 years have been incomparable. It is now possible to prevent the relentless course of active MS much better and aim at better outcomes for our patients. Are better outcomes achieved with "no evidence of disease activity" or NEDA? What is NEDA and does it matter?. This article is protected by copyright. All rights reserved.
August 13, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Neda Jamalimoghadam, Shahrzad Yektatalab, Marzieh Momennasab, Abbas Ebadi, Najaf Zare
BACKGROUND: The feeling of safety makes an important contribution to the sense of well-being and quality of care for hospitalized adolescents, who are at a higher risk of feeling unsafe. Feeling unsafe during hospitalization may have a negative impact on recovery. Nurses must be sensitive to the possibility that patients feel unsafe, even in the absence of obvious direct physical threat. PURPOSE: This study explores the experiences of hospitalized adolescents to obtain an understanding of psychological safety...
August 11, 2018: Journal of Nursing Research: JNR
Geoff Strange, David S Celermajer, Tom Marwick, David Prior, Marcus Ilton, Jim Codde, Gregory M Scalia, Simon Stewart, Max Bulsara, Eli Gabbay, David Playford
The National Echocardiography Database Australia (NEDA) is a new echocardiography database collecting digital measurements on both a retrospective and prospective basis. To date, echocardiographic data from 435,133 individuals (aged 61.6 ± 17.9 years) with linkage to 59,725 all-cause deaths during a median of 40 months follow-up have been collected. These data will inform a number of initial analyses focusing on pulmonary hypertension, aortic stenosis and the role of artificial intelligence to facilitate accurate diagnoses of cardiac abnormalities...
July 17, 2018: American Heart Journal
Neda Stjepanovic, Tracy L Stockley, Philippe L Bedard, Jeanna M McCuaig, Melyssa Aronson, Spring Holter, Kara Semotiuk, Natasha B Leighl, Raymond Jang, Monika K Krzyzanowska, Amit M Oza, Abha Gupta, Christine Elser, Lailah Ahmed, Lisa Wang, Suzanne Kamel-Reid, Lillian L Siu, Raymond H Kim
BACKGROUND: Matched tumor-normal sequencing, applied in precision cancer medicine, can identify unidentified germline Medically Actionable Variants (gMAVS) in cancer predisposition genes. We report patient preferences for the return of additional germline results, and describe various gMAV scenarios delivered through a clinical genetics service. METHODS: Tumor profiling was offered to 1960 advanced cancer patients, of which 1556 underwent tumor-normal sequencing with multigene hotspot panels containing 20 cancer predisposition genes...
August 9, 2018: BMC Medical Genomics
Irene Moreno-Torres, Coral González-García, Marco Marconi, Aranzazu García-Grande, Luis Rodríguez-Esparragoza, Víctor Elvira, Elvira Ramil, Lucía Campos-Ruíz, Ruth García-Hernández, Fátima Al-Shahrour, Coral Fustero-Torre, Alicia Sánchez-Sanz, Antonio García-Merino, Antonio José Sánchez López
Background: Fingolimod is a functional sphingosine-1-phosphate antagonist approved for the treatment of multiple sclerosis (MS). Fingolimod affects lymphocyte subpopulations and regulates gene expression in the lymphocyte transcriptome. Translational studies are necessary to identify cellular and molecular biomarkers that might be used to predict the clinical response to the drug. In MS patients, we aimed to clarify the differential effects of fingolimod on T, B, and natural killer (NK) cell subsets and to identify differentially expressed genes in responders and non-responders (NRs) to treatment...
2018: Frontiers in Immunology
Amir Hadi, Hamed Mohammadi, Zohreh Hadi, Neda Roshanravan, Marzieh Kafeshani
We performed a meta-analysis to evaluate the efficacy of cumin supplementation on plasma lipid concentration in adult population. The search included PubMed, Scopus, ISI Web of Science, Google Scholar, and the Cochrane library (up to January 2018) to identify randomized controlled trials (RCTs) investigating the effects of cumin supplementation on serum lipid parameters. Mean difference (MD) was pooled using a random-effects model. Meta-analysis of data from six eligible RCTs with 376 participants showed a significant reduction in plasma concentration of total cholesterol (MD [95% CI] -10...
August 8, 2018: Phytotherapy Research: PTR
Soghra Yassaei, Hengameh Zandi, Hossein Aghili, Elahe Rafiei, Neda Mosayebi
Background and aims: This study was done to compare the antibacterial effect of Photodynamic therapy (PDT) on streptococcus mutans ( S. mutans ) using two different light sources and photosensitizers (PS). Materials and methods: Five groups were studied in this research:no light and no toluidine blue ortho (TBO) as PS for control group, irradiation only (CO2 laser or Nd:YAG laser), and irradiation with PS (CO2 laser and TBO or Nd:YAG laser and TBO). Standard suspensions of S...
June 30, 2018: Laser Therapy
Neda O Đorđević, Nevena Todorović, Irena T Novaković, Lato L Pezo, Boris Pejin, Vesna Maraš, Vele V Tešević, Snežana B Pajović
Screens of antioxidant activity (AA) of various natural products have been a focus of the research community worldwide. This work aimed to differentiate selected samples of Merlot wines originated from Montenegro, with regard to phenolic profile and antioxidant capacity studied by survival rate, total sulfhydryl groups and activities of glutathione peroxidase (GPx), glutathione reductase and catalase in H₂O₂⁻stressed Saccharomyces cerevisiae cells. In this study, DPPH assay was also performed. Higher total phenolic content leads to an enhanced AA under both conditions...
August 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Neda Eslami, Taraneh Movahed, Masoumeh Asadi
OBJECTIVES: The aim of this study was to evaluate parents' perception of the oral health-related quality of life (OHRQoL) of autistic children in Iran, and to determine the quality of life of their families in relation to child' oral health status. STUDY DESIGN: 70 families with at least one child with autism, and 70 families with normal children were enrolled. Parents' perceptions of the OHRQoL of children were assessed using pre-validated PedsQL oral health scale questionnaire...
August 7, 2018: Journal of Clinical Pediatric Dentistry
Neda Sadat Nazaripanah, Yadollah Abolfathi Momtaz, Farideh Mokhtari, Robab Sahaf
Sleep disorder is associated with poor quality of life in old age. Therefore, it is imperative to identify contributing factors leading to sleep disorder. The current study aimed to examine the impact of urinary incontinence on sleep complaint after controlling for potential sociodemographic and health covariates. Materials and Methods: A cross-sectional study was conducted on a sample of 184 community dwelling older adults 60 years and older in Yazd, Iran, 2016. In order to obtain the sample a multistage proportional random sampling technique was employed...
March 2018: Sleep Science
Sara Lariviere, Reinder Vos de Wael, Casey Paquola, Seok-Jun Hong, Bratislav Misic, Neda Bernasconi, Andrea Bernasconi, Leonardo Bonilha, Boris Bernhardt
Rapid advances in neuroimaging and network science have produced powerful tools and measures to appreciate human brain organization at multiple spatial and temporal scales. It is now possible to obtain increasingly meaningful representations of whole-brain structural and functional brain networks and to formally assess macroscale principles of network topology. In addition to its utility in characterizing healthy brain organization, individual variability, and lifespan-related changes, there is high promise of network neuroscience for the conceptualization, and ultimately, management of brain disorders...
August 5, 2018: Brain Connectivity
Dragana Matekalo, Marijana Skorić, Tijana Nikolić, Lazar Novaković, Milana Lukić, Jelena Božunović, Neda Aničić, Biljana Filipović, Danijela Mišić
While bioactive properties of Centaurium erythraea Rafn secoiridoid glucosides (SG) are widely recognized, many aspects related to their biochemistry, metabolism and relationship to the overall plant physiology are not yet understood. Here we present for the first time an insight into the molecular background of organ-specific and genotype-dependent constitutive biosynthesis of secoiridoids in C. erythraea, by comparing chemical profiles and secoiridoid glucosides-related gene expression. Genes encoding enzymes for intermediate steps of secoiridoids biosynthesis up to secologanin have been identified by analysing transcriptomic data from C...
August 2, 2018: Phytochemistry
Shahriar Alipour, Ebrahim Sakhinia, Alireza Khabbazi, Nasser Samadi, Zohreh Babaloo, Mahdi Azad, Somayeh Abolhasani, Jafar Farhadi, Golamreza Jadideslam, Neda Roshanravan, Mohammad Nouri
BACKGROUND: IL-6 mRNA expression is significantly high in many autoimmune diseases such as Behçet's disease; this is often related with more aggressive phenotypes. Nevertheless, the essential molecular process for its high expression has not been completely realized. The aim of this study was undertaken to estimate the gene copy number variation and promoter methylation to IL-6's high expression. METHODS: This study was performed on 51 patients and 61 healthy controls...
July 31, 2018: Reumatología Clinica
Soo Jin Park, Gary Yeung, Neda Vesselinova, Jody Kreiman, Patricia A Keating, Abeer Alwan
Little is known about human and machine speaker discrimination ability when utterances are very short and the speaking style is variable. This study compares text-independent speaker discrimination ability of humans and machines based on utterances shorter than 2 s in two different speaking styles (read sentences and speech directed towards pets, characterized by exaggerated prosody). Recordings of 50 female speakers drawn from the UCLA Speaker Variability Database were used as stimuli. Performance of 65 human listeners was compared to i-vector-based automatic speaker verification systems using mel-frequency cepstral coefficients, voice quality features, which were inspired by a psychoacoustic model of voice perception, or their combination by score-level fusion...
July 2018: Journal of the Acoustical Society of America
Neda Izadi, Seyed Davood Mirtorabi, Farid Najafi, Bashir Nazparvar, Hajar Nazari Kangavari, Seyed Saeed Hashemi Nazari
OBJECTIVES: Suicide is a major global public health problem and much burden in the societies. This study aims to calculate the years of life lost (YLL) due to suicide and investigate its trend in Iran. METHODS: Information on deaths due to suicide in Iran was extracted from Iran Legal Medicine Organization. The years of life lost was calculated in each year according to gender and age-groups. To examine the trend for different years, joinpoint regression was used...
August 3, 2018: International Journal of Public Health
Shirin Pourafshar, Neda S Akhavan, Kelli S George, Elizabeth M Foley, Sarah A Johnson, Behnam Keshavarz, Negin Navaei, Anis Davoudi, Elizabeth A Clark, Bahram H Arjmandi
Without appropriate interventions, prediabetes is typically followed by type II diabetes. Eggs are a rich source of important nutrients including protein, vitamins, minerals, carotenoids and lecithin. In this 12-week, parallel, randomized controlled trial, 42 overweight or obese individuals between the ages of 40 and 75 years with pre- and type II-diabetes were included. Participants were randomly assigned to receive either one large egg per day or an equivalent amount of egg substitute for 12 weeks. Blood samples were obtained to analyze lipid profile and biomarkers associated with glycemic control at all time points...
August 3, 2018: Food & Function
Fereshteh Aliasghari, Mohammad Asghari Jafarabadi, Neda Lotfi Yaghin, Reza Mahdavi
PURPOSE: The present study was performed to develop the Persian version of Power of Food Scale (PFS) questionnaire (PFS-P) and to assess the hedonic hunger in Iranian adult population. In addition, associations between individual differences, including sex and body mass index (BMI) and the appetitive motives measured by the PFS-P were assessed. METHODS: Eight hundred and twenty participants were studied. The PFS-P, the International Physical Activity Questionnaire, the Three-Factor Eating Questionnaire, and a questionnaire pertaining to demographic characteristics were completed for all participants...
July 31, 2018: Eating and Weight Disorders: EWD
Brandon McNally, Neda Black, Loren E Golitz, Joshua A Wisell
Extramammary Paget disease (EMPD) is a malignant tumor typically found in apocrine-rich areas of the skin, particularly in the anogenital region. Some germinative apocrine-differentiating cells might exist on the trunk, preferentially in Asian individuals. Ectopic EMPD arises in nonapocrine-bearing areas, specifically the nongerminative milk line. We present a case of a 67-year-old Thai man with a slowly progressive, pruritic, erythematous to brown plaque on the right lower back of 30 years' duration. Histopathologic examination of 2 scouting biopsies revealed a proliferation of large cells with pleomorphic nuclei, prominent nucleoli, and abundant pale to clear cytoplasm within the epidermis...
June 2018: Cutis; Cutaneous Medicine for the Practitioner
Masoud Khorshidi, Ashraf Moini, Elham Alipoor, Neda Rezvan, Sattar Gorgani-Firuzjaee, Mehdi Yaseri, Mohammad Javad Hosseinzadeh-Attar
The aim of this study was to investigate the effect of quercetin on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome (PCOS). In this randomized, double-blind, placebo-controlled trial, 78 overweight or obese women (25 ≤ BMI ≤ 40 kg/m2 , 20-40 years) with PCOS were recruited. Patients were randomized to receive 1,000 mg/day quercetin or placebo for 12 weeks. Resistin plasma concentration and gene expression in peripheral blood mononuclear cells, parameters of glucose homeostasis, circulatory testosterone, luteinizing hormone (LH), and sex hormone-binding globulin, and anthropometries were assessed at baseline and at the end of the study...
July 30, 2018: Phytotherapy Research: PTR
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