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Heart *Ischemia Heart Disease

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https://www.readbyqxmd.com/read/30116344/the-diagnostic-value-of-three-dimensional-ct-angiography-for-patients-with-acute-coronary-artery-disease
#1
Libo Li, Jing Hao, Shi Qu, Yancheng Fang
Computed tomography angiography (CTA) is an efficient method for the diagnosis of heart disease. However, few contemporary studies have evaluated the prognostic value of three-dimensional (3D)-CTA for patients with acute coronary artery disease. The aim of the present study was to investigate the diagnostic value of 3D-CTA for patients with acute coronary artery disease. A total of 136 patients with suspected acute coronary artery disease were recruited and received conventional coronary angiography (CCA) and 3D-CTA...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30115811/remote-ischemic-conditioning-a-promising-therapeutic-intervention-for-multi-organ-protection
#2
Da Zhou, Jiayue Ding, Jingyuan Ya, Liqun Pan, Yuan Wang, Xunming Ji, Ran Meng
Despite decades of formidable exploration, multi-organ ischemia-reperfusion injury (IRI) encountered, particularly amongst elderly patients with clinical scenarios, such as age-related arteriosclerotic vascular disease, heart surgery and organ transplantation, is still an unsettled conundrum that besets clinicians. Remote ischemic conditioning (RIC), delivered via transient, repetitive noninvasive IR interventions to distant organs or tissues, is regarded as an innovative approach against IRI. Based on the available evidence, RIC holds the potential of affording protection to multiple organs or tissues, which include not only the heart and brain, but also others that are likely susceptible to IRI, such as the kidney, lung, liver and skin...
August 16, 2018: Aging
https://www.readbyqxmd.com/read/30105952/integration-of-omics-techniques-dronedarone-affects-cardiac-remodeling-in-the-infarction-border-zone
#3
Ravi K Chilukoti, Josefine Lendeckel, Katrin Darm, Alicja Bukowska, Andreas Goette, Marc Sühling, Kirsten Utpatel, Barbara Peters, Georg Homuth, Uwe Völker, Carmen Wolke, Christian Scharf, Uwe Lendeckel
Dronedarone improves microvascular flow during atrial fibrillation and reduces the infarct size in acute models of myocardial infarction. However, dronedarone might be harmful in patients with recent decompensated heart failure and increases mortality in patients with permanent atrial fibrillation. A pathophysiological explanation for these discrepant data is lacking. This study investigated the effects of dronedarone on gene and protein expression in the infarcted area and border zone in pigs subjected to anterior ischemia/reperfusion myocardial infarction...
July 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/30105559/-acute-diseases-of-the-brain-and-heart-a-reciprocal-culprit-victim-relationship
#4
REVIEW
E Egerer, S Siemonsen, F Erbguth
The reciprocal culprit-victim relationship between the brain and the heart leads to dysfunction and damage to the other organ, especially in acute and severe diseases of one of both organs. In addition, both organ systems can be affected by identical systemic processes, e. g., arteriosclerotic changes. Cardiac embolic formation and pumping failure lead to focal cerebral ischemia or global hypoxia. Cerebral diseases leading to cardiac changes are acute cerebrovascular attacks such as cerebral infarction, intracerebral hemorrhage and subarachnoid hemorrhage, as well as epileptic seizures...
August 13, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/30104954/untargeted-metabolomics-analysis-of-ischemia-reperfusion-injured-hearts-ex-vivo-from-sedentary-and-exercise-trained-rats
#5
Traci L Parry, Joseph W Starnes, Sara K O'Neal, James R Bain, Michael J Muehlbauer, Aubree Honcoop, Amro Ilaiwy, Peter Christopher, Cam Patterson, Monte S Willis
Introduction: The effects of exercise on the heart and its resistance to disease are well-documented. Recent studies have identified that exercise-induced resistance to arrhythmia is due to the preservation of mitochondrial membrane potential. Objectives: To identify novel metabolic changes that occur parallel to these mitochondrial alterations, we performed non-targeted metabolomics analysis on hearts from sedentary and exercise-trained rats challenged with isolated heart ischemia-reperfusion injury (I/R)...
January 2018: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/30101855/outcomes-in-patients-with-critical-limb-ischemia-due-to-arteriosclerosis-obliterans-who-did-not-undergo-arterial-reconstruction
#6
Daisuke Akagi, Katsuyuki Hoshina, Atsushi Akai, Kota Yamamoto
The prevalence of arteriosclerosis obliterans (ASO) and critical limb ischemia (CLI) is currently increasing, and arterial reconstruction is often attempted to salvage the limb. Some patients cannot undergo attempted revascularization because of contraindications, and they only receive conservative treatment. In this study, we investigate the comorbidities and survival rates of patients with CLI who receive conservative treatment. Thirty-five patients with CLI due to ASO, who had not undergone revascularization surgery (C group), were enrolled...
August 11, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30101537/neuraminidase-mediated-desialylation-augments-aav9-mediated-gene-expression-in-skeletal-muscle
#7
Hongling Zhu, Tao Wang, R John Lye, Brent A French, Brian H Annex
BACKGROUND: Following systemic delivery, AAV9-mediated gene expression is significantly increased in ischemic versus non-ischemic muscle, suggesting AAV9 as an attractive vector for treating peripheral arterial disease (PAD). Potential mechanisms underlying ischemia-augmented expression include: 1) increased vascular permeability, and 2) "unmasking" of endogenous AAV9 receptors. Here, we endeavored to reconstitute the ischemic induction of AAV9 in vivo, using local injection of histamine (to increase vascular permeability) and neuraminidase (to desialylate cell surface glycans)...
August 12, 2018: Journal of Gene Medicine
https://www.readbyqxmd.com/read/30100007/chest-pain-if-it-is-not-the-heart-what-is-it
#8
REVIEW
Sharron Rushton, Margaret J Carman
Noncardiac chest pain is an angina-type discomfort without indication of ischemia. Diagnosis can be difficult because of its heterogeneous nature. Classification varies by specialty; gastroenterology uses the terminology gastroesophageal reflux disease related versus non-gastroesophageal reflux disease related. Other disciplines recognize noncardiac chest pain etiologies as having gastrointestinal, musculoskeletal, psychiatric, or pulmonary/other as underlying etiologies. Diagnostics yield a specific cause for effective treatment, which is aimed at the underlying etiology, but it is not always possible...
September 2018: Nursing Clinics of North America
https://www.readbyqxmd.com/read/30093255/french-society-of-cardiology-guidelines-on-exercise-tests-part-2-indications-for-exercise-tests-in-cardiac-diseases
#9
Dany-Michel Marcadet, Bruno Pavy, Gilles Bosser, Frédérique Claudot, Sonia Corone, Hervé Douard, Marie-Christine Iliou, Bénédicte Vergès-Patois, Pascal Amedro, Thierry Le Tourneau, Caroline Cueff, Taniela Avedian, Alain Cohen Solal, François Carré
The exercise test is performed routinely in cardiology; its main indication is the diagnosis of myocardial ischemia, evaluated along with the subject's pretest probability and cardiovascular risk level. Other criteria, such as analysis of repolarization, must be taken into consideration during the interpretation of an exercise test, to improve its predictive value. An exercise test is also indicated for many other cardiac diseases (e.g. rhythm and conduction disorders, severe asymptomatic aortic stenosis, hypertrophic cardiomyopathy, peripheral artery disease, hypertension)...
August 6, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/30093254/french-society-of-cardiology-guidelines-on-exercise-tests-part-1-methods-and-interpretation
#10
Dany-Michel Marcadet, Bruno Pavy, Gilles Bosser, Frédérique Claudot, Sonia Corone, Hervé Douard, Marie-Christine Iliou, Bénédicte Vergès-Patois, Pascal Amedro, Thierry Le Tourneau, Caroline Cueff, Taniela Avedian, Alain Cohen Solal, François Carré
The exercise test is still a key examination in cardiology, used for the diagnosis of myocardial ischemia, as well as for the clinical evaluation of other heart diseases. The cardiopulmonary exercise test can further define functional capacity and prognosis for any given cardiac pathology. These new guidelines focus on methods, interpretation and indications for an exercise test or cardiopulmonary exercise test, as summarized below. The safety rules associated with the exercise test must be strictly observed...
August 6, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/30092074/aspergillus-endocarditis-diagnostic-criteria-and-predictors-of-outcome-a-retrospective-cohort-study
#11
Marwa Sayed Meshaal, Dina Labib, Karim Said, Mohammed Hosny, Mohammed Hassan, Said Abd Al Aziz, Amani Elkholy, Mervat Anani, Hussien Rizk
BACKGROUND: Fungal Endocarditis (FE), a relatively rare disease, has a high rate of mortality and is associated with multiple morbidities. Aspergillus endocarditis (AE) is severe form of FE. Incidence of AE has increased and is expected to rise due to an increased frequency of invasive procedures, cardiac devices and prosthetic valves together with increased use of immune system suppressors. AE lacks most of the clinical criteria used to diagnose infective endocarditis (IE), where blood culture is almost always negative, and fever may be absent...
2018: PloS One
https://www.readbyqxmd.com/read/30086775/angptl3-possibly-promotes-cardiac-angiogenesis-through-improving-proangiogenic-ability-of-endothelial-progenitor-cells-after-myocardial-infarction
#12
Fei Luo, Panyun Wu, Jingfei Chen, Yuan Guo, Jiangang Wang, Xiangping Li, Zhenfei Fang
Angiopoietin Like protein 3 (ANGPTL3) is at present considered as a central molecular target for therapy designed to reduce atherogenic lipids and atherosclerosis. However, concerns about the safety of inactivation of ANGPTL3 in patients with coronary artery disease (CAD) especially myocardial infarction (MI) have been raised. ANGPTL3 is reported to possess proangiogenic property. Angiogenesis is critical to the recovery of MI. Endothelial progenitor cells (EPCs) have multiple differentiation potential and play an important role in the angiogenesis post-MI...
August 7, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/30082698/the-detrimental-effects-of-glucocorticoids-exposure-during-pregnancy-on-offspring-s-cardiac-functions-mediated-by-hypermethylation-of-bone-morphogenetic-protein-4
#13
Jieying Peng, Yuhao Zhou, Zhiyu Zhang, Zhiming Wang, Lingtong Gao, Xiao Zhang, Zhou Fang, Guangyao Li, Huaiyan Chen, Hongxing Yang, Lu Gao
The intra-uterine and external environmental factors not only affect the early development of fetuses, their interaction with genesis will also substantially program the physiological functions of offspring throughout life. Synthetic glucocorticoid (GC) is widely used for the management of women at risk of preterm birth or undergone autoimmune diseases. However, excess GC might cause a number of chronic diseases in later life. In the present study, we set up a programming rat model by daily injection of dexamethasone (DEX) since 14...
August 6, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/30081805/-risk-of-stroke-after-exacerbation-of-ischemic-heart-disease-data-of-3%C3%A2-years-follow-up
#14
V A Brazhnik, L O Minushkina, M A Evdokimova, A S Galyavich, S N Tereshchenko, N A Koziolova, M G Glezer, A V Yagoda, E V Khorolets, E N Dankovtseva, O I Boeva, V O Konstantinov, D A Zateishchikov
PURPOSE: to analyze possible associations of clinical and genetic factors with development of ischemic stroke after exacerbation of ischemic heart disease (IHD). MATERIALS AND METHODS: The Russian multicenter study aimed at assessment of risk of unfavorable outcomes after exacerbation of IHD "Exacerbation of IHD: logical probabilistic ways to course prognostication for optimization of treatment" (meaning of Cyrillic acronym - oracle) was conducted in 16 centers of 7 cities in Russia...
July 2018: Kardiologiia
https://www.readbyqxmd.com/read/30078786/a-physiologist-observing-and-reporting-supra-pharmacologic-dobutamine-stress-testing-can-we-trust-them-and-can-we-trust-the-results
#15
EDITORIAL
Thomas R Porter
In a study, published in this issue of Echo Research and Practice , Ntoskas et al retrospectively analyzed the safety of a cardiac physiologist performing, and interpreting, Dobutamine stress echocardiography (DSE) in of 300 patients undergoing DSE for the detection of inducible reversible ischemia, myocardial viability and valvular heart disease. While safety during the tests themselves did not appear to be compromised with this unsupervised approach, the interpretation of these DSEs causes concerns regarding broad patient safety relative to misread results...
September 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/30078011/pharmacological-signatures-of-the-exenatide-nanoparticles-complex-against-myocardial-ischemia-reperfusion-injury
#16
Yi Zhang, Ping Qian, Hong Zhou, Ruilin Shen, Bo Hu, Yajun Shen, Xiaofang Zhang, Xiaohua Shen, Guangtao Xu, Limin Jin
BACKGROUND/AIMS: Myocardial ischemia/reperfusion (I/R) injury (MI/RI) is a critical cause of death in patients with heart disease. However, the pharmaco-therapeutical outcome for MI/RI remains unsatisfactory. Innovative approaches for enhancing drug sensitivity and recovering myocardial function in MI/RI treatment are urgently needed. The purpose of this study was to evaluate the protective effects of exenatide-loaded poly(L-lysine)-poly(ethylene glycol)-poly(L-lysine) (PLL-PEG-PLL) nanoparticles (NPs) against MI/RI...
August 3, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/30077925/p2x7-receptor-is-involved-in-lung-injuries-induced-by-ischemia-reperfusion-in-pulmonary-arterial-hypertension-rats
#17
Lian Duan, Guo-Huang Hu, Yi-Jin Li, Cheng-Liang Zhang, Meng Jiang
Pulmonary arterial hypertension (PAH) is a progressive disease that ultimately leads to right heart failure and death. Current strategies are ineffective to prevent and cure PAH, especially in those who undergo cardiopulmonary bypass. P2 × 7 receptors (P2 × 7Rs) have been implied to participate in the pathogenesis of PAH and injuries induced by ischemia-reperfusion (IR). In the present study, we aimed to assess the potential therapeutic effects of anti-P2 × 7Rs on PAH and IR-induced lung injuries in rats and explore their underlying cellular and molecular mechanisms...
August 2, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/30077533/peri-operative-acute-kidney-injury-upon-cardiac-surgery-time-of-day
#18
Sandro Ninni, Claire Seunes, Staniel Ortmans, Stéphanie Mouton, Thomas Modine, Mohamed Koussa, Bruno Jegou, Jean-Louis Edme, Bart Staels, David Montaigne, Augustin Coisne
BACKGROUND: A relevant morning-afternoon variation in ischemia-reperfusion (IR) insult after cardiac surgery has been demonstrated. We speculated that the biorhythm might also impact systemic reactions involved in acute kidney injury (AKI) following cardiac surgery. We aimed at investigating incidence, determinants and prognostic impact of AKI in a large cohort of patients referred for surgical aortic valve replacement (SAVR) according to surgery time-of-day. METHODS: Between 2009 and 2015, we explored consecutive patients referred to our Heart Valve Center (CHU Lille) for first SAVR...
July 19, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30077186/usefulness-of-postsystolic-shortening-to-diagnose-coronary-artery-disease-and-predict-future-cardiovascular-events-in-stable-angina-pectoris
#19
Philip Brainin, Søren Hoffmann, Thomas Fritz-Hansen, Flemming Javier Olsen, Jan Skov Jensen, Tor Biering-Sørensen
BACKGROUND: Postsystolic shortening (PSS) may occur during myocardial ischemia. We aimed to assess the diagnostic and prognostic potential of PSS in patients with suspected stable angina pectoris (SAP). METHODS: This is a prospective study of patients with suspected SAP (N = 293), no prior cardiac history, and normal ejection fraction, who were examined by speckle-tracking echocardiography, coronary angiography, and exercise electrocardiogram. We excluded patients with known heart disease (ischemia, heart failure, valve disease), bundle branch block, pathological Q-waves, and arrhythmias...
August 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/30065573/coronary-artery-dominance-may-predict-future-risk-of-atrial-fibrillation
#20
Abdullah Nabi Aslan, Serdal Baştuğ, Hacı Ahmet Kasapkara, Murat Can Güney, Serkan Sivri, Engin Bozkurt
Background: Ischemia of the atria and conductive system of the heart results in greater atrial electrophysiological changes and propensity for atrial fibrillation. P wave duration and dispersion have been proposed to be useful for the prediction of paroxysmal atrial fibrillation (PAF). This study aimed to investigate the effect of coronary artery dominance on P wave duration and dispersion. Methods: The study population included 194 patients with left dominant circulation (LDC) and 200 age- and gender-matched controls with right dominant circulation (RDC) and without coronary artery disease based on invasive coronary angiography findings...
July 2018: Acta Cardiologica Sinica
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