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Cohen and. Neck

Michael B Cohen, Louis F Insalaco, Christopher R Tonn, Jeffrey H Spiegel
Background: Patient's pursuing aesthetic surgery often inquire about the success of the procedure. Having objective data for these patients improves preoperative counseling. To assess patient satisfaction after aesthetic chondrolaryngoplasty using specifically developed outcomes assessment instrument and to evaluate the anatomy of the vocalis insertion on the thyroid cartilage and its effect on the extent of surgical resection. Methods: Retrospective survey of patients who underwent chondrolaryngoplasty from 2006 to 2012...
October 2018: Plastic and Reconstructive Surgery. Global Open
David A Daar, Salma A Abdou, Joshua M Cohen, Stelios C Wilson, Jamie P Levine
BACKGROUND: The medial sural artery perforator (MSAP) flap offers thin, pliable tissue with a relatively long pedicle and low donor site morbidity. This study explores the characteristics and uses of the MSAP flap as well as postoperative outcomes and complications. METHODS: A systematic literature review was performed using PubMed, Embase, and Cochrane CENTRAL to identify all cases of MSAP flap reconstruction. Descriptive and meta-analyses were performed on pooled outcomes...
November 26, 2018: Plastic and Reconstructive Surgery
Melanie Boxberg, Christine Bollwein, Korinna Jöhrens, Peer-Hendrik Kuhn, Bernhard Haller, Katja Steiger, Klaus-Dietrich Wolff, Andreas Kolk, Moritz Jesinghaus, Wilko Weichert
AIMS: Squamous cell carcinoma of the oral cavity (OSCC) is a common tumour entity with a variable, partially highly aggressive clinical course. Recently, we proposed a novel (three-tiered) clinically useful grading scheme strongly associated with patient outcome in OSCC, consisting of a sum score of the histomorphological patterns tumour budding and cell nest size which outperforms WHO based grading algorithms currently in use. The aim of our study was to probe for interobserver and intraobserver reliability of this novel grading system...
December 8, 2018: Journal of Clinical Pathology
Ezra E W Cohen, Denis Soulières, Christophe Le Tourneau, José Dinis, Lisa Licitra, Myung-Ju Ahn, Ainara Soria, Jean-Pascal Machiels, Nicolas Mach, Ranee Mehra, Barbara Burtness, Pingye Zhang, Jonathan Cheng, Ramona F Swaby, Kevin J Harrington
BACKGROUND: There are few effective treatment options for patients with recurrent or metastatic head-and-neck squamous cell carcinoma. Pembrolizumab showed antitumour activity and manageable toxicity in early-phase trials. We aimed to compare the efficacy and safety of pembrolizumab versus standard-of-care therapy for the treatment of head-and-neck squamous cell carcinoma. METHODS: We did a randomised, open-label, phase 3 study at 97 medical centres in 20 countries...
November 30, 2018: Lancet
Pascale André, Caroline Denis, Caroline Soulas, Clarisse Bourbon-Caillet, Julie Lopez, Thomas Arnoux, Mathieu Bléry, Cécile Bonnafous, Laurent Gauthier, Ariane Morel, Benjamin Rossi, Romain Remark, Violette Breso, Elodie Bonnet, Guillaume Habif, Sophie Guia, Ana Ines Lalanne, Caroline Hoffmann, Olivier Lantz, Jérôme Fayette, Agnès Boyer-Chammard, Robert Zerbib, Pierre Dodion, Hormas Ghadially, Maria Jure-Kunkel, Yannis Morel, Ronald Herbst, Emilie Narni-Mancinelli, Roger B Cohen, Eric Vivier
Checkpoint inhibitors have revolutionized cancer treatment. However, only a minority of patients respond to these immunotherapies. Here, we report that blocking the inhibitory NKG2A receptor enhances tumor immunity by promoting both natural killer (NK) and CD8+ T cell effector functions in mice and humans. Monalizumab, a humanized anti-NKG2A antibody, enhanced NK cell activity against various tumor cells and rescued CD8+ T cell function in combination with PD-x axis blockade. Monalizumab also stimulated NK cell activity against antibody-coated target cells...
November 13, 2018: Cell
S Prinsloo, D I Rosenthal, R Lyle, S M Garcia, S Gabel-Zepeda, R Cannon, E Bruera, L Cohen
Acute pain from mucositis in patients with head and neck cancer (HNC) undergoing radiation therapy (RT) is common, and may not respond well to narcotics. We used low resolution electromagnetic tomography z-score neurofeedback (LFBz) to investigate whether patients could modify brain wave activity associated with acute pain and whether this would reduce the experience of pain. HNC patients scheduled for RT had baseline pre-pain onset measures (EEG and numeric rating scale) collected before RT and then at pain onset before using analgesics, after each LFBz session and at the end of RT...
November 13, 2018: Brain Topography
William A Mehan, Christopher J Stapleton, Scott B Raymond
PURPOSE: Neck CT angiography (CTA) is frequently performed in conjunction with head CTA in patients presenting with clinical signs and symptoms concerning for acute intracranial hemorrhage, despite relatively low appropriateness (ACR Appropriateness Criteria 2-6). This decision is sometimes justified by suggesting that CTA neck findings are useful in planning subsequent catheter angiography. METHODS: We investigated the value of neck CTA in patients with suspected acute intracranial hemorrhage by reviewing 220 head and neck CTAs performed in our emergency room over a 24-month period for the indication of hemorrhage or headache...
November 5, 2018: Emergency Radiology
Katarzyna Bednarczyk, Marta Gawin, Mykola Chekan, Agata Kurczyk, Grzegorz Mrukwa, Monika Pietrowska, Joanna Polanska, Piotr Widlak
Identification of biomarkers for molecular classification of cancer and for differentiation between cancerous and normal epithelium remains a vital issue in the field of head and neck cancer. Here we aimed to compare the ability of proteome and lipidome components to discriminate oral cancer from normal mucosa. Tissue specimens including squamous cell cancer and normal epithelium were analyzed by MALDI mass spectrometry imaging. Two molecular domains of tissue components were imaged in serial sections-peptides (resulting from trypsin-processed proteins) and lipids (primarily zwitterionic phospholipids), then regions of interest corresponding to cancer and normal epithelium were compared...
November 3, 2018: Journal of Molecular Histology
Vincent Dewitte, Robby De Pauw, Lieven Danneels, Katie Bouche, Arne Roets, Barbara Cagnie
OBJECTIVE: To examine the interrater reliability and agreement of a pain mechanisms-based classification for patients with nonspecific neck pain (NSNP). METHODS: Design - Observational, cross-sectional reliability study with a simultaneous examiner design. SETTING: University hospital-based outpatient physical therapy clinic. PARTICIPANTS: A random sample of 48 patients, aged between 18 and 75 years old, with a primary complaint of neck pain was included...
October 29, 2018: Brazilian Journal of Physical Therapy
Kripa Guram, Maria Nunez, John Einck, Loren K Mell, Ezra Cohen, P Dominick Sanders, Sayuri Miyauchi, Elizabeth Weihe, Razelle Kurzrock, Sarah Boles, Andrew B Sharabi
Background: Undifferentiated pleomorphic sarcoma (UPS) of the maxillary sinus is an extremely rare malignancy of the head and neck. Surgery is the mainstay of treatment for UPS; however, proximity to vital structures makes it challenging to achieve negative surgical margins. Adjuvant therapy including radiation therapy with or without chemotherapy is generally indicated. Despite advances in multimodality treatment, objective response rates to available therapies and prognosis of metastatic UPS remain dismal...
2018: Frontiers in Oncology
Hoda Badr, Krista Herbert, Mark D Bonnen, Joshua A Asper, Timothy Wagner
Background: Head and neck cancer (HNC) adversely affects the psychological (i.e., depression, anxiety) and marital adjustment of patients and their spouses. Dyadic coping refers to how couples cope with stress. It includes positive actions like sharing practical or emotional concerns (i.e., problem- and emotion-focused stress communication; PFSC, EFSC), and engaging in problem- or emotion-focused actions to support each other (problem- and emotion-focused dyadic coping; PFDC, EFDC). It also includes negative actions like avoidance (negative dyadic coping; NEGDC)...
2018: Frontiers in Psychology
Anca M Avram, Natalja Rosculet, Nazanene H Esfandiari, Paul G Gauger, Barbra S Miller, Mark Cohen, David T Hughes
PURPOSE: The aim of this study was to determine clinical outcomes in patients with differentiated thyroid cancer after surgery and activity-adjusted I therapy informed by diagnostic I scans with SPECT/CT (Dx scan). METHODS: Single-institution retrospective cohort study analysis of clinical outcomes after 1 to 5 years (mean, 39.6 ± 23.4 months) of follow-up in 350 patients with differentiated thyroid cancer associated with histopathologic risk factors, nodal metastases, and/or distant metastases...
October 27, 2018: Clinical Nuclear Medicine
Joshua M Bauml, Ravi Vinnakota, Yeun-Hee Anna Park, Susan E Bates, Tito Fojo, Charu Aggarwal, Jessica Di Stefano, Christina Knepley, Sewanti Limaye, Ronac Mamtani, Juan Wisnivesky, Nevena Damjanov, Corey J Langer, Roger B Cohen, Keith Sigel
BACKGROUND: The addition of cisplatin or cetuximab to radiation therapy (RT) improves outcomes in comparison with RT alone in the nonoperative management of head and neck squamous cell carcinoma (HNSCC), but limited data exist for comparing these approaches. Using Veterans Health Affairs data, this study compared the outcomes of patients treated with RT plus cisplatin or cetuximab. METHODS: Patients with stage III to IVb HNSCC who had been treated nonsurgically with RT and cisplatin or cetuximab from 2000 to 2016 within the Veterans Health Affairs system were identified...
October 20, 2018: Cancer
Irit Cohen-Manheim, Maya Siman-Tov, Irina Radomislensky, Kobi Peleg
BACKGROUND: Dog bites are a substantial public health concern. Rarely has hospitalizations resulting from dog bites been examined. We examined, at a national level, demographic and injury characteristics of dog-bites injuries requiring hospitalization to target prevention programs and policies for those who are at higher risk. METHODS: Data on hospitalizations due to dog-bite injuries with an ICD9-CM E906.0 coding were extracted from the Israeli National Trauma Registry between 2009-2016...
October 3, 2018: Injury
Gabriel Lopez, M Kay Garcia, Wenli Liu, Michael Spano, Susan Underwood, Seyedeh S Dibaj, Yisheng Li, Rocio Moguel, Janet Williams, Eduardo Bruera, Lorenzo Cohen
Background: Increased access to complementary therapies such as acupuncture at academic medical centers has created new opportunities for management of cancer and cancer treatment related symptoms. Methods: Patients presenting for acupuncture treatment during calendar year 2016 at an outpatient integrative medicine clinic in a comprehensive cancer center were asked to complete a modified Edmonton Symptom Assessment Scale (ESAS; 16 symptoms, score 0-10, 10 worst possible) before and after each visit. ESAS subscales analyzed included global (GDS; score 0-90), physical (PHS, 0-60) and psychological distress (PSS, 0-20)...
2018: Journal of Cancer
Letícia B Calixtre, Ana Beatriz Oliveira, Lianna Ramalho de Sena Rosa, Susan Armijo-Olivo, Corine M Visscher, Francisco Alburquerque-Sendín
BACKGROUND: Studies exploring interventions targeting the cervical spine to improve symptoms in patients with temporomandibular disorders (TMD) are limited. OBJECTIVES: To determine whether mobilisation of the upper cervical region and craniocervical flexor training decreased orofacial pain, increased mandibular function and pressure pain thresholds (PPTs) of the masticatory muscles and decreased headache impact in women with TMD when compared to no intervention...
October 11, 2018: Journal of Oral Rehabilitation
Charu Aggarwal, Roger B Cohen, Matthew P Morrow, Kimberly A Kraynyak, Albert J Sylvester, Dawson M Knoblock, Joshua M Bauml, Gregory S Weinstein, Alexander Lin, Jean Boyer, Lindsay Sakata, Sophie Tan, Aubrey Anton, Kelsie Dickerson, Drishty Mangrolia, Russell Vang, Michael Dallas, Sandra Oyola, Susan Duff, Mark Esser, Rakesh Kumar, David Weiner, Ildiko Csiki, Mark L Bagarazzi
Purpose: Clinical responses with programmed death (PD-1) receptor-directed antibodies occur in about 20% of patients with advanced head and neck squamous cell cancer (HNSCCa). Viral neoantigens, such as the E6/E7 proteins of HPV16/18, are attractive targets for therapeutic immunization and offer an immune activation strategy that may be complementary to PD-1 inhibition. Experimental Design: We report phase Ib/II safety, tolerability, and immunogenicity results of immunotherapy with MEDI0457 (DNA immunotherapy targeting HPV16/18 E6/E7 with IL12 encoding plasmids) delivered by electroporation with CELLECTRA constant current device...
September 21, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Joshua M Bauml, Ravi Vinnakota, Yeun-Hee Anna Park, Susan E Bates, Tito Fojo, Charu Aggarwal, Sewanti Limaye, Nevena Damjanov, Jessica Di Stefano, Christine Ciunci, Eric M Genden, Juan P Wisnivesky, Rocco Ferrandino, Ronac Mamtani, Corey J Langer, Roger B Cohen, Keith Sigel
Background: Concurrent chemoradiotherapy is an established component of the nonoperative management of locally advanced head and neck squamous cell carcinoma (HNSCC), but the standard dose of 100 mg/m2 cisplatin every 3 weeks is associated with clinically significant toxicity. Interest in a more tolerable regimen has led to the widespread use of weekly lower dose cisplatin, but few randomized trials have compared these approaches. Methods: We examined outcomes of patients with stage III-IVb HNSCC treated with definitive intent chemoradiotherapy using either high-dose cisplatin (HDC) or low-dose cisplatin (LDC), using population-based Veterans Affairs data...
September 18, 2018: Journal of the National Cancer Institute
Matthew G Crowson, Betty C Tong, Hui-Jie Lee, Yao Song, David H Harpole, Harrison N Jones, Seth Cohen
OBJECTIVES/HYPOTHESIS: Vocal fold paralysis/paresis (VFP) is an uncommon but serious complication following esophagectomy. The objectives of this study were to: 1) identify the prevalence of VFP and associated complications after esophagectomy in the United States, and 2) determine the utilization and otolaryngology-head and neck surgery/speech-language pathology (OHNS/SLP) and predictors of such utilization in the management of these patients. STUDY DESIGN: Retrospective database analysis...
September 19, 2018: Laryngoscope
Alexandra Cohen, Lola E Ianovski, Saul Frenkiel, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Keith Richardson, Martin Black, Christina MacDonald, Gabrielle Chartier, Zeev Rosberger, Melissa Henry
OBJECTIVES: While patients with head and neck cancer (HNC) are known to experience higher levels of anxiety and depression, they do not always use psychosocial oncology (PSO) services when available. This study aimed to investigate barriers to PSO service utilization in this patient population, with the goal of appropriately targeting outreach interventions. METHODS: A conceptual model based on the Behavioral Model of Health Services Use was tested in 84 patients newly diagnosed with a first occurrence of HNC followed longitudinally over one year, including variables collected through self-administered questionnaires, Structured Clinical Interviews for DSM (SCID-I), and medical chart reviews...
September 14, 2018: Psycho-oncology
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