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Cohen and. Neck

Gabriel Lopez, M Kay Garcia, Wenli Liu, Michael Spano, Susan Underwood, Seyedeh S Dibaj, Yisheng Li, Rocio Moguel, Janet Williams, Eduardo Bruera, Lorenzo Cohen
Background: Increased access to complementary therapies such as acupuncture at academic medical centers has created new opportunities for management of cancer and cancer treatment related symptoms. Methods: Patients presenting for acupuncture treatment during calendar year 2016 at an outpatient integrative medicine clinic in a comprehensive cancer center were asked to complete a modified Edmonton Symptom Assessment Scale (ESAS; 16 symptoms, score 0-10, 10 worst possible) before and after each visit. ESAS subscales analyzed included global (GDS; score 0-90), physical (PHS, 0-60) and psychological distress (PSS, 0-20)...
2018: Journal of Cancer
Letícia Bojikian Calixtre, Ana Beatriz Oliveira, Lianna Ramalho de Sena Rosa, Susan Armijo-Olivo, Corine Mirjam Visscher, Francisco Alburquerque-Sendín
BACKGROUND: Studies exploring interventions targeting the cervical spine to improve symptoms in patients with temporomandibular disorders (TMD) are limited. OBJECTIVES: To determine whether mobilization of the upper cervical region and craniocervical flexor training decreased orofacial pain, increased mandibular function and pressure pain thresholds (PPT) of the masticatory muscles, and decreased headache impact in women with TMD when compared to no intervention...
October 11, 2018: Journal of Oral Rehabilitation
Charu Aggarwal, Roger B Cohen, Matthew P Morrow, Kimberly A Kraynak, Albert J Sylvester, Dawson M Knoblock, Joshua Bauml, Gregory S Weinstein, Alexander Lin, Jean Boyer, Lindsay Sakata, Sophie Tan, Aubrey Anton, Kelsie Dickerson, Drishty Mangrolia, Russell Vang, Michael Dallas, Sandra Oyola, Susan Duff, Mark T Esser, Rakesh Kumar, David B Weiner, Ildiko Csiki, Mark Bagarazzi
PURPOSE: Clinical responses with programmed death (PD-1) receptor directed antibodies occur in about 20% of patients with advanced head and neck squamous cell cancer (HNSCCa). Viral neoantigens, such as the E6/E7 proteins of HPV16/18 are attractive targets for therapeutic immunization, and offer an immune activation strategy that may be complementary to PD-1 inhibition. EXPERIMENTAL DESIGN: We report Phase Ib/II safety, tolerability and immunogenicity results of immunotherapy with MEDI0457 (DNA immunotherapy targeting HPV16/18 E6/E7 with IL-12 encoding plasmids) delivered by electroporation with CELLECTRA® constant current device...
September 21, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Joshua M Bauml, Ravi Vinnakota, Yeun-Hee Anna Park, Susan E Bates, Tito Fojo, Charu Aggarwal, Sewanti Limaye, Nevena Damjanov, Jessica Di Stefano, Christine Ciunci, Eric M Genden, Juan P Wisnivesky, Rocco Ferrandino, Ronac Mamtani, Corey J Langer, Roger B Cohen, Keith Sigel
Background: Concurrent chemoradiotherapy is an established component of the nonoperative management of locally advanced head and neck squamous cell carcinoma (HNSCC), but the standard dose of 100 mg/m2 cisplatin every 3 weeks is associated with clinically significant toxicity. Interest in a more tolerable regimen has led to the widespread use of weekly lower dose cisplatin, but few randomized trials have compared these approaches. Methods: We examined outcomes of patients with stage III-IVb HNSCC treated with definitive intent chemoradiotherapy using either high-dose cisplatin (HDC) or low-dose cisplatin (LDC), using population-based Veterans Affairs data...
September 18, 2018: Journal of the National Cancer Institute
Matthew G Crowson, Betty C Tong, Hui-Jie Lee, Yao Song, David H Harpole, Harrison N Jones, Seth Cohen
OBJECTIVES/HYPOTHESIS: Vocal fold paralysis/paresis (VFP) is an uncommon but serious complication following esophagectomy. The objectives of this study were to: 1) identify the prevalence of VFP and associated complications after esophagectomy in the United States, and 2) determine the utilization and otolaryngology-head and neck surgery/speech-language pathology (OHNS/SLP) and predictors of such utilization in the management of these patients. STUDY DESIGN: Retrospective database analysis...
September 19, 2018: Laryngoscope
Alexandra Cohen, Lola E Ianovski, Saul Frenkiel, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Keith Richardson, Martin Black, Christina MacDonald, Gabrielle Chartier, Zeev Rosberger, Melissa Henry
OBJECTIVES: While patients with head and neck cancer (HNC) are known to experience higher levels of anxiety and depression, they do not always use psychosocial oncology (PSO) services when available. This study aimed to investigate barriers to PSO service utilization in this patient population, with the goal of appropriately targeting outreach interventions. METHODS: A conceptual model based on the Behavioral Model of Health Services Use was tested in 84 patients newly diagnosed with a first occurrence of HNC followed longitudinally over one year, including variables collected through self-administered questionnaires, Structured Clinical Interviews for DSM (SCID-I), and medical chart reviews...
September 14, 2018: Psycho-oncology
Brennan Vail, Melissa C Morgan, Hilary Spindler, Amelia Christmas, Susanna R Cohen, Dilys M Walker
BACKGROUND: Globally, neonatal mortality accounts for nearly half of under-five mortality, and intrapartum related events are a leading cause. Despite the rise in neonatal resuscitation (NR) training programs in low- and middle-income countries, their impact on the quality of NR skills amongst providers with limited formal medical education, particularly those working in rural primary health centers (PHCs), remains incompletely understood. METHODS: This study evaluates the impact of PRONTO International simulation training on the quality of NR skills in simulated resuscitations and live deliveries in rural PHCs throughout Bihar, India...
September 3, 2018: BMC Pediatrics
Sagit Stern, Sharon Tzelnick, Aviram Mizrachi, Maya Cohen, Thomas Shpitzer, Gideon Bachar
Objectives Ultrasonography (US) is a reliable tool for the preoperative localization of parathyroid adenomas (PTAs). The aim of this study was to evaluate the accuracy of US for estimating both the size and the location of PTAs and the effect of operator expertise. Study Design Retrospective cohort study. Setting A single tertiary medical center. Subjects and Methods All patients who underwent parathyroidectomy for primary hyperparathyroidism between 1996 and 2012 were included. The estimated PTA localization and size by preoperative ultrasound were compared with the intraoperative findings and pathology report...
August 14, 2018: Otolaryngology—Head and Neck Surgery
Ju Yeon Kim, Sung Wan Byun, Seung-Ho Shin, Mi Sun Chun
BACKGROUND: When evaluating hearing disability in medicolegal cases, an average of thresholds at several frequencies is calculated using pure tone audiometry. Occasionally, there are instances in which thresholds at certain frequencies are omitted. One typical example is the threshold at 3 kHz (H3k). The American Academy of Otolaryngology-Head and Neck Surgery Committee on Hearing and Equilibrium (1995) suggested that the average of thresholds at 2 kHz and 4 kHz (H24k) could replace H3k for a comparison of results between studies...
2018: PloS One
Natasha Cohen, Stacey Fedewa, Amy Y Chen
Head and neck malignancies comprise a heterogeneous group of malignancies that cause significant morbidity to those affected. These malignancies are associated with specific risk factors and exposures, some of which impact prognosis. The most common risk factors for developing head and neck cancers are tobacco and alcohol use. Marijuana and e-cigarettes, occupational exposures, and use of topical substances have also been linked to head and neck cancers. Human papilloma virus has been associated with oropharyngeal cancer...
August 2, 2018: Oral and Maxillofacial Surgery Clinics of North America
Piotr Kocur, Maciej Wilski, Jacek Lewandowski, Dawid Łochyński
BACKGROUND: Work-related neck disorders are among the most common dysfunctions in office workers. Understanding cervical myofascial mechanical characteristics that differentiate symptomatic from asymptomatic office workers is crucial for the understanding of musculoskeletal dysfunctions in workers with neck pain. OBJECTIVE: To assess the effect of moderate work-related neck disorders on head posture and stiffness and perceived pain threshold of the upper trapezius (UT) and sternocleidomastoid (SCM) muscles...
July 19, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
Boris Peltenburg, Juliette P Driessen, Marielle E P Philippens, Frank A Pameijer, Jonas Castelijns, Jan Willem Dankbaar, Bart Dorgelo, Charlotte A H Lange, Frederick J A Meijer, Walter M Palm, Stefan D Roosendaal, Stefan C A Steens, Berit M Verbist, Inge Stegeman, Luuk M Janssen, Remco de Bree, Chris H J Terhaard
INTRODUCTION: For the detection of local recurrences of head and neck squamous cell carcinomas (HNSCC) after (chemo)radiation, diagnostic imaging is generally performed. Diffusion weighted magnetic resonance imaging (DW-MRI) has been proven to be able to adequately diagnose the presence of cancer. However evaluation of DW-MR images for recurrences is difficult and could be subject to individual interpretation. AIM: To determine the interobserver agreement, intraobserver agreement and influence of experience of radiologists in the assessment of DW-MRI in patients clinically suspected of local recurrent HNSCC after (chemo)radiation...
August 2018: European Journal of Radiology
Jordan J Becker, Shawn L Copeland, Emily L Botterbusch, Rajal G Cohen
OBJECTIVES: To determine feasibility and potential of Alexander technique (AT) group classes for chronic neck pain and to assess changes in self-efficacy, posture, and neck muscle activity as potential mechanisms for pain reduction. DESIGN: A single-group, multiple-baseline design, with two pre-tests to control for regression toward the mean, a post-test immediately after the intervention, and another post-test five weeks later to examine retention of benefits. Participants were predominately middle-aged; all had experienced neck pain for at least six months...
August 2018: Complementary Therapies in Medicine
Man Hung, Charles L Saltzman, Maren W Voss, Jerry Bounsanga, Richard Kendall, Ryan Spiker, Brandon Lawrence, Darrel Brodke
BACKGROUND CONTEXT: The Patient-Reported Outcomes Information System (PROMIS) instruments are an important advancement in the use of PROs, but need to be evaluated with longitudinal data to determine whether they are responsive to change in specific clinical populations. PURPOSE: The purpose of this study was to assess the responsiveness of the PROMIS Physical Function (PF), PROMIS Pain Interference (PI), Neck Disability Index (NDI), and the Oswestry Disability Index (ODI)...
June 30, 2018: Spine Journal: Official Journal of the North American Spine Society
Robert L Ferris, Nabil F Saba, Barbara J Gitlitz, Robert Haddad, Ammar Sukari, Prakash Neupane, John C Morris, Krzysztof Misiukiewicz, Julie E Bauman, Moon Fenton, Antonio Jimeno, Douglas R Adkins, Charles J Schneider, Assuntina G Sacco, Keisuke Shirai, Daniel W Bowles, Michael Gibson, Tobenna Nwizu, Raphael Gottardo, Kristi L Manjarrez, Gregory N Dietsch, James Kyle Bryan, Robert M Hershberg, Ezra E W Cohen
Importance: Immunotherapy for recurrent and/or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) is promising. The toll-like receptor 8 (TLR8) agonist motolimod may stimulate innate and adaptive immunity. Objective: To determine whether motolimod improves outcomes for R/M SCCHN when combined with standard therapy. Design, Setting, and Participants: The Active8 study was a multicenter, randomized, double-blind, placebo-controlled clinical trial enrolling adult patients (age ≥18 years) with histologically confirmed R/M SCCHN of the oral cavity, oropharynx, hypopharynx, or larynx between October 2013 and August 2015...
June 21, 2018: JAMA Oncology
Renata Ferrarotto, William N William, Jennifer E Tseng, Shanthi Marur, Dong M Shin, Barbara Murphy, Ezra E W Cohen, Christopher Y Thomas, Richard Willey, Jan Cosaert, Nusrat Harun, J Jack Lee, Ignacio W Wistuba, Robert I Haddad, Bonnie S Glisson
OBJECTIVES: Cixutumumab (CIX) and cetuximab (CET) monoclonal antibodies block ligand-binding to insulin-like growth factor-1 receptor (IGF-1R) and epidermal growth factor receptor (EGFR) respectively. The objective of this study was to assess the efficacy of CIX alone or combined with CET in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) patients. METHODS: In this open-label phase II trial, 91 R/M HNSCC patients who progressed within 90 days of platinum-based chemotherapy, were randomized to CIX 10 mg/kg alone or with CET 500 mg/m2 every 2 weeks...
July 2018: Oral Oncology
Brandon Worley, Andrew J Nemechek, Samantha Stoler, Joel L Cohen
BACKGROUND: Alternative therapies are favored by some patients. In skin cancer, this may be to try to avoid surgery out of fear for the procedure and its functional or cosmetic consequences. Frequently, use of these therapies is not curative and can cause harm. Our objective is to detail a case where black salve was used as a natural remedy for an atypical fibroxanthoma and resulted in a severe burn. We highlight the challenges of communicating effective treatment options for those who have strong beliefs concerning natural remedies after a cancer diagnosis...
June 1, 2018: Journal of Drugs in Dermatology: JDD
Alex K Bryant, Elena J Sojourner, Lucas K Vitzthum, Kaveh Zakeri, Hanjie Shen, Cammie Nguyen, James D Murphy, Joseph A Califano, Ezra E W Cohen, Loren K Mell
Background: Previous studies have reported conflicting information regarding the prognostic role of p16 in nonoropharyngeal head and neck squamous cell carcinoma (HNSCC). Methods: Using the US Veterans Affairs database, we analyzed 1448 patients with locoregionally advanced HNSCC and known p16 status diagnosed between 2005 and 2015 and treated with surgery, radiotherapy, or chemoradiotherapy. Tumor p16 status was determined through manual review of pathology reports of primary tumor specimens...
June 5, 2018: Journal of the National Cancer Institute
Prasad Vijay Barre, Gadiraju Padmaja, Suvashisa Rana, Tiamongla
Background: Cancer pervades many dimensions of an individual's life - demanding a holistic treatment approach. However, studies with combined medical and psychological interventions (MPIs) are sparse. High-level stress and poor quality of life (QoL) can hinder patients' prognosis. The study thus aimed to analyze the impact of combined medical and psychological (psychoeducation, relaxation technique-guided imagery, and cognitive therapy) interventions on stress and QoL of cancer patients - head and neck, breast, and lung cancers...
May 2018: Indian Journal of Psychological Medicine
Wassim Chemaitilly, Laurie E Cohen, Sogol Mostoufi-Moab, Briana C Patterson, Jill H Simmons, Lillian R Meacham, Hanneke M van Santen, Charles A Sklar
Endocrine complications are highly prevalent in childhood cancer survivors. Approximately 50% of survivors will experience at least one hormonal disorder over the course of their lives. Endocrine complications often are observed in survivors previously treated with radiation to the head, neck, or pelvis. We provide an overview the most common endocrine late effects seen in survivors, including hypothalamic-pituitary dysfunction, primary thyroid dysfunction, obesity, diabetes mellitus, metabolic syndrome, and decreased bone mineral density...
July 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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