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https://www.readbyqxmd.com/read/30086155/can-an-average-of-thresholds-at-2-khz-and-4-khz-substitute-for-the-threshold-at-3-khz-in-pure-tone-audiometry-a-study-based-on-the-korean-national-health-and-nutrition-examination-survey-2010-2012
#1
Ju Yeon Kim, Sung Wan Byun, Seung-Ho Shin, Mi Sun Chun
BACKGROUND: When evaluating hearing disability in medicolegal cases, an average of thresholds at several frequencies is calculated using pure tone audiometry. Occasionally, there are instances in which thresholds at certain frequencies are omitted. One typical example is the threshold at 3 kHz (H3k). The American Academy of Otolaryngology-Head and Neck Surgery Committee on Hearing and Equilibrium (1995) suggested that the average of thresholds at 2 kHz and 4 kHz (H24k) could replace H3k for a comparison of results between studies...
2018: PloS One
https://www.readbyqxmd.com/read/30078696/epidemiology-and-demographics-of-the-head-and-neck-cancer-population
#2
REVIEW
Natasha Cohen, Stacey Fedewa, Amy Y Chen
Head and neck malignancies comprise a heterogeneous group of malignancies that cause significant morbidity to those affected. These malignancies are associated with specific risk factors and exposures, some of which impact prognosis. The most common risk factors for developing head and neck cancers are tobacco and alcohol use. Marijuana and e-cigarettes, occupational exposures, and use of topical substances have also been linked to head and neck cancers. Human papilloma virus has been associated with oropharyngeal cancer...
August 2, 2018: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/30031965/female-office-workers-with-moderate-neck-pain-have-increased-anterior-positioning-of-the-cervical-spine-and-stiffness-of-upper-trapezius-myofascial-tissue-in-sitting-posture
#3
Piotr Kocur, Maciej Wilski, Jacek Lewandowski, Dawid Lochynski
BACKGROUND: Work-related neck disorders are among the most common dysfunctions in office workers. Understanding cervical myofascial mechanical characteristics that differentiate symptomatic from asymptomatic office workers is crucial for the understanding of musculoskeletal dysfunctions in workers with neck pain. OBJECTIVE: To assess the effect of moderate work-related neck disorders on head posture and stiffness and perceived pain threshold of the upper trapezius (UT) and sternocleidomastoid muscles...
July 19, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/30017269/the-interobserver-agreement-in-the-detection-of-recurrent-hnscc-using-mri-including-diffusion-weighted-mri
#4
Boris Peltenburg, Juliette P Driessen, Marielle E P Philippens, Frank A Pameijer, Jonas Castelijns, Jan Willem Dankbaar, Bart Dorgelo, Charlotte A H Lange, Frederick J A Meijer, Walter M Palm, Stefan D Roosendaal, Stefan C A Steens, Berit M Verbist, Inge Stegeman, Luuk M Janssen, Remco de Bree, Chris H J Terhaard
INTRODUCTION: For the detection of local recurrences of head and neck squamous cell carcinomas (HNSCC) after (chemo)radiation, diagnostic imaging is generally performed. Diffusion weighted magnetic resonance imaging (DW-MRI) has been proven to be able to adequately diagnose the presence of cancer. However evaluation of DW-MR images for recurrences is difficult and could be subject to individual interpretation. AIM: To determine the interobserver agreement, intraobserver agreement and influence of experience of radiologists in the assessment of DW-MRI in patients clinically suspected of local recurrent HNSCC after (chemo)radiation...
August 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/30012397/preliminary-evidence-for-feasibility-efficacy-and-mechanisms-of-alexander-technique-group-classes-for-chronic-neck-pain
#5
Jordan J Becker, Shawn L Copeland, Emily L Botterbusch, Rajal G Cohen
OBJECTIVES: To determine feasibility and potential of Alexander technique (AT) group classes for chronic neck pain and to assess changes in self-efficacy, posture, and neck muscle activity as potential mechanisms for pain reduction. DESIGN: A single-group, multiple-baseline design, with two pre-tests to control for regression toward the mean, a post-test immediately after the intervention, and another post-test five weeks later to examine retention of benefits. Participants were predominately middle-aged; all had experienced neck pain for at least six months...
August 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29969730/responsiveness-of-the-promis-ndi-and-odi-instruments-in-patients-with-spinal-disorders
#6
Man Hung, Charles L Saltzman, Maren W Voss, Jerry Bounsanga, Richard Kendall, Ryan Spiker, Brandon Lawrence, Darrel Brodke
BACKGROUND CONTEXT: The Patient-Reported Outcomes Information System (PROMIS) instruments are an important advancement in the use of PROs, but need to be evaluated with longitudinal data to determine whether they are responsive to change in specific clinical populations. PURPOSE: The purpose of this study was to assess the responsiveness of the PROMIS Physical Function (PF), PROMIS Pain Interference (PI), Neck Disability Index (NDI) and the Oswestry Disability Index (ODI)...
June 30, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29931076/effect-of-adding-motolimod-to-standard-combination-chemotherapy-and-cetuximab-treatment-of-patients-with-squamous-cell-carcinoma-of-the-head-and-neck-the-active8-randomized-clinical-trial
#7
Robert L Ferris, Nabil F Saba, Barbara J Gitlitz, Robert Haddad, Ammar Sukari, Prakash Neupane, John C Morris, Krzysztof Misiukiewicz, Julie E Bauman, Moon Fenton, Antonio Jimeno, Douglas R Adkins, Charles J Schneider, Assuntina G Sacco, Keisuke Shirai, Daniel W Bowles, Michael Gibson, Tobenna Nwizu, Raphael Gottardo, Kristi L Manjarrez, Gregory N Dietsch, James Kyle Bryan, Robert M Hershberg, Ezra E W Cohen
Importance: Immunotherapy for recurrent and/or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) is promising. The toll-like receptor 8 (TLR8) agonist motolimod may stimulate innate and adaptive immunity. Objective: To determine whether motolimod improves outcomes for R/M SCCHN when combined with standard therapy. Design, Setting, and Participants: The Active8 study was a multicenter, randomized, double-blind, placebo-controlled clinical trial enrolling adult patients (age ≥18 years) with histologically confirmed R/M SCCHN of the oral cavity, oropharynx, hypopharynx, or larynx between October 2013 and August 2015...
June 21, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29909907/randomized-phase-ii-trial-of-cixutumumab-alone-or-with-cetuximab-for-refractory-recurrent-metastatic-head-and-neck-squamous-cell-carcinoma
#8
Renata Ferrarotto, William N William, Jennifer E Tseng, Shanthi Marur, Dong M Shin, Barbara Murphy, Ezra E W Cohen, Christopher Y Thomas, Richard Willey, Jan Cosaert, Nusrat Harun, J Jack Lee, Ignacio W Wistuba, Robert I Haddad, Bonnie S Glisson
OBJECTIVES: Cixutumumab (CIX) and cetuximab (CET) monoclonal antibodies block ligand-binding to insulin-like growth factor-1 receptor (IGF-1R) and epidermal growth factor receptor (EGFR) respectively. The objective of this study was to assess the efficacy of CIX alone or combined with CET in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) patients. METHODS: In this open-label phase II trial, 91 R/M HNSCC patients who progressed within 90 days of platinum-based chemotherapy, were randomized to CIX 10 mg/kg alone or with CET 500 mg/m2 every 2 weeks...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29879257/naturopathic-self-treatment-of-an-atypical-fibroxanthoma-lessons-for-dermatologic-surgery
#9
Brandon Worley, Andrew J Nemechek, Samantha Stoler, Joel L Cohen
BACKGROUND: Alternative therapies are favored by some patients. In skin cancer, this may be to try to avoid surgery out of fear for the procedure and its functional or cosmetic consequences. Frequently, use of these therapies is not curative and can cause harm. Our objective is to detail a case where black salve was used as a natural remedy for an atypical fibroxanthoma and resulted in a severe burn. We highlight the challenges of communicating effective treatment options for those who have strong beliefs concerning natural remedies after a cancer diagnosis...
June 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29878161/prognostic-role-of-p16-in-nonoropharyngeal-head-and-neck-cancer
#10
Alex K Bryant, Elena J Sojourner, Lucas K Vitzthum, Kaveh Zakeri, Hanjie Shen, Cammie Nguyen, James D Murphy, Joseph A Califano, Ezra E W Cohen, Loren K Mell
Background: Previous studies have reported conflicting information regarding the prognostic role of p16 in nonoropharyngeal head and neck squamous cell carcinoma (HNSCC). Methods: Using the US Veterans Affairs database, we analyzed 1448 patients with locoregionally advanced HNSCC and known p16 status diagnosed between 2005 and 2015 and treated with surgery, radiotherapy, or chemoradiotherapy. Tumor p16 status was determined through manual review of pathology reports of primary tumor specimens...
June 5, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29875530/stress-and-quality-of-life-in-cancer-patients-medical-and-psychological-intervention
#11
Prasad Vijay Barre, Gadiraju Padmaja, Suvashisa Rana, Tiamongla
Background: Cancer pervades many dimensions of an individual's life - demanding a holistic treatment approach. However, studies with combined medical and psychological interventions (MPIs) are sparse. High-level stress and poor quality of life (QoL) can hinder patients' prognosis. The study thus aimed to analyze the impact of combined medical and psychological (psychoeducation, relaxation technique-guided imagery, and cognitive therapy) interventions on stress and QoL of cancer patients - head and neck, breast, and lung cancers...
May 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29874130/endocrine-late-effects-in-childhood-cancer-survivors
#12
Wassim Chemaitilly, Laurie E Cohen, Sogol Mostoufi-Moab, Briana C Patterson, Jill H Simmons, Lillian R Meacham, Hanneke M van Santen, Charles A Sklar
Endocrine complications are highly prevalent in childhood cancer survivors. Approximately 50% of survivors will experience at least one hormonal disorder over the course of their lives. Endocrine complications often are observed in survivors previously treated with radiation to the head, neck, or pelvis. We provide an overview the most common endocrine late effects seen in survivors, including hypothalamic-pituitary dysfunction, primary thyroid dysfunction, obesity, diabetes mellitus, metabolic syndrome, and decreased bone mineral density...
July 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29866397/intraobserver-and-interobserver-reliability-of-recategorized-neer-classification-in-differentiating-2-part-surgical-neck-fractures-from-multi-fragmented-proximal-humeral-fractures-in-116-patients
#13
Bakir O Sumrein, Ville M Mattila, Vesa Lepola, Minna K Laitinen, Antti P Launonen
BACKGROUND: Optimal fracture classification should be simple and reproducible and should guide treatment. For proximal humeral fractures, the Neer classification is commonly used. However, intraobserver and interobserver reliability of the Neer classification has been shown to be poor. In clinical practice, it is essential to differentiate 2-part surgical neck fractures from multi-fragmented fractures. Thus, the aim of this study was to evaluate whether surgeons can differentiate 2-part surgical neck fractures from multi-fragmented fractures using plain radiographs and/or computed tomography (CT)...
June 1, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29778996/stent-and-flow-diverter-assisted-treatment-of-acutely-ruptured-brain-aneurysms
#14
José E Cohen, J Moshe Gomori, Ronen R Leker, Sergey Spektor, Hosni Abu El Hassan, Eyal Itshayek
OBJECTIVE: We present our experience with stent techniques in the management of acutely ruptured aneurysms, focusing on aneurysm occlusion rates, intraprocedural complications, and late outcomes. METHODS: We retrospectively reviewed the clinical records of patients treated by stent techniques during the early acute phase of aneurysmal rupture, from June 2011 to June 2016. Patients who underwent stenting for the management of unruptured aneurysms, or in a delayed fashion for a ruptured lesion, were excluded...
May 19, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29772418/differences-between-manual-and-automatic-analysis-in-determining-the-severity-of-obstructive-sleep-apnea-using-home-sleep-apnea-testing
#15
Gonzalo Labarca, Jorge Dreyse, Constanza Salas, Andrea Contreras, Gonzalo Nazar, Maria I Gaete, Jorge Jorquera
INTRODUCTION: Home sleep apnea testing (HSAT) is a diagnostic measure for obstructive sleep apnea hypopnea syndrome (OSAHS) in moderate/high risk patients. Some HSAT companies contain automatic analysis (AA). However, guidelines recommend manual analysis (MA) despite the weak evidence for this recommendation. OBJECTIVE: Evaluate the concordance between AA and MA of HSAT to make either a diagnosis and severity classification. METHODS: We evaluated AA and MA of HSAT between 2015 and 2016...
July 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29771690/heavily-pigmented-epithelioid-melanoma-with-loss-of-protein-kinase-a-regulatory-subunit-%C3%AE-expression
#16
Jarish N Cohen, Jessica A Spies, Fawn Ross, Angela Bohlke, Timothy H McCalmont
Heavily pigmented melanocytic neoplasms are genotypically and phenotypically diverse. Recently, a subset of this histopathologic spectrum was shown to harbor recurrent genetic alterations in the gene-encoding protein kinase A regulatory subunit-α (PRKAR1A). To date, no histopathologic descriptions of melanomas arising from this pathway have been described. We present a case of a darkly pigmented papule arising on the posterior neck of a 28-year-old man. Microscopically, the heavily pigmented compound melanocytic proliferation was centered in the dermis with permeation into the superficial subcutis...
May 16, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29763967/machine-learning-algorithms-for-outcome-prediction-in-chemo-radiotherapy-an-empirical-comparison-of-classifiers
#17
Timo M Deist, Frank J W M Dankers, Gilmer Valdes, Robin Wijsman, I-Chow Hsu, Cary Oberije, Tim Lustberg, Johan van Soest, Frank Hoebers, Arthur Jochems, Issam El Naqa, Leonard Wee, Olivier Morin, David R Raleigh, Wouter Bots, Johannes H Kaanders, José Belderbos, Margriet Kwint, Timothy Solberg, René Monshouwer, Johan Bussink, Andre Dekker, Philippe Lambin
PURPOSE: Machine learning classification algorithms (classifiers) for prediction of treatment response are becoming more popular in radiotherapy literature. General Machine learning literature provides evidence in favor of some classifier families (random forest, support vector machine, gradient boosting) in terms of classification performance. The purpose of this study is to compare such classifiers specifically for (chemo)radiotherapy datasets and to estimate their average discriminative performance for radiation treatment outcome prediction...
July 2018: Medical Physics
https://www.readbyqxmd.com/read/29762165/improved-fracture-prediction-using-different-fracture-risk-assessment-tool-adjustments-in-hiv-infected-women
#18
Jingyan Yang, Anjali Sharma, Qiuhu Shi, Kathryn Anastos, Mardge H Cohen, Elizabeth T Golub, Deborah Gustafson, Daniel Merenstein, Wendy J Mack, Phyllis C Tien, Jeri W Nieves, Michael T Yin
OBJECTIVES: A fracture risk assessment tool (FRAX) using clinical risk factors (CRFs) alone underestimates fracture risk in HIV-infected men. Our objective was to determine whether accuracy of FRAX would be improved by considering HIV as a cause of secondary osteoporosis, and further improved with addition of dual-energy X-ray absorptiometry parameters in HIV-infected women. DESIGN: Subgroup analysis of Women's Interagency HIV Study. METHODS: We included 1148 women (900 HIV-infected and 248 uninfected) over age 40 with data to approximate FRAX CRFs and 10-year observational data for incident fragility fractures; 181 (20%) HIV-infected women had dual-energy X-ray absorptiometry data...
July 31, 2018: AIDS
https://www.readbyqxmd.com/read/29723320/the-effect-of-too-much-caring-a-preliminary-study
#19
Meriting Thokoane, C Peter Owen
PURPOSE: To determine the presence of burnout and psychiatric morbidity among prosthodontic residents and prosthodontists working in a maxillofacial prosthetic clinic and to compare these outcomes between those treating cancer patients and those not treating cancer patients. MATERIALS AND METHODS: Two questionnaires were used: the Maslach Burnout Inventory (MBI) and the General Health Questionnaire (GHQ-12). MBI assesses the three components of burnout (emotional exhaustion, depersonalization, and personal accomplishment), and the GHQ-12 screens for nonpsychotic psychiatric morbidity...
May 2018: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29669079/blended-learning-pain-neuroscience-education-for-people-with-chronic-spinal-pain-randomized-controlled-multicenter-trial
#20
Anneleen Malfliet, Jeroen Kregel, Mira Meeus, Nathalie Roussel, Lieven Danneels, Barbara Cagnie, Mieke Dolphens, Jo Nijs
Background: Available evidence favors the use of pain neuroscience education (PNE) in patients with chronic pain. However, PNE trials are often limited to small sample sizes and, despite the current digital era, the effects of blended-learning PNE (ie, the combination of online digital media with traditional educational methods) have not yet been investigated. Objective: The study objective was to examine whether blended-learning PNE is able to improve disability, catastrophizing, kinesiophobia, and illness perceptions...
May 1, 2018: Physical Therapy
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