Sydney C Joseph, Samson Eugin Simon, Margaret S Bohm, Minjeong Kim, Madeline E Pye, Boston W Simmons, Dillon G Graves, Stacey M Thomas-Gooch, Ubaid A Tanveer, Jeremiah R Holt, Suriyan Ponnusamy, Laura M Sipe, D Neil Hayes, Katherine L Cook, Ramesh Narayanan, Joseph F Pierre, Liza Makowski
Bariatric surgery is associated with improved outcomes for several cancers, including breast cancer (BC), although the mechanisms mediating this protection are unknown. We hypothesized that elevated bile acid pools detected after bariatric surgery may be factors that contribute to improved BC outcomes. Patients with greater expression of the bile acid receptor FXR displayed improved survival in specific aggressive BC subtypes. FXR is a nuclear hormone receptor activated by primary bile acids. Therefore, we posited that activating FXR using an established FDA-approved agonist would induce anticancer effects...
March 30, 2024: Cancers