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https://www.readbyqxmd.com/read/27932786/state-medicaid-expansion-tobacco-cessation-coverage-and-number-of-adult-smokers-enrolled-in-expansion-coverage-united-states-2016
#1
Anne DiGiulio, Meredith Haddix, Zach Jump, Stephen Babb, Anna Schecter, Kisha-Ann S Williams, Kat Asman, Brian S Armour
In 2015, 27.8% of adult Medicaid enrollees were current cigarette smokers, compared with 11.1% of adults with private health insurance, placing Medicaid enrollees at increased risk for smoking-related disease and death (1). In addition, smoking-related diseases are a major contributor to Medicaid costs, accounting for about 15% (>$39 billion) of annual Medicaid spending during 2006-2010 (2). Individual, group, and telephone counseling and seven Food and Drug Administration (FDA)-approved medications are effective treatments for helping tobacco users quit (3)...
December 9, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27932628/potential-effectiveness-of-pictorial-warning-labels-that-feature-the-images-and-personal-details-of-real-people
#2
Emily Brennan, Erin Maloney, Yotam Ophir, Joseph N Cappella
INTRODUCTION: Pictorial warning labels (PWL) that use photographs and the personal details of real people whose health has been affected by smoking (testimonial PWL) provide factual information about the consequences of tobacco use. METHODS: 924 adult current smokers participated in an online experiment that tested responses to four types of warning labels: 1) non-testimonial text warning labels (TWL) (currently on packs in the United States); 2) non-testimonial PWL (previously proposed by the United States Food and Drug Administration); 3) image only testimonial PWL (created for this study); 4) image + personal details testimonial PWL (created for study)...
December 8, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27931908/the-efficacy-of-atomoxetine-in-treating-adult-attention-deficit-hyperactivity-disorder-adhd-a-meta-analysis-of-controlled-trials
#3
Vinutha Ravishankar, Suresh Vedaveni Chowdappa, Vivek Benegal, Kesavan Muralidharan
Atomoxetine, a non-stimulant, is FDA approved drug used in the management of adult ADHD. Since the presentation of adult ADHD is different from the childhood onset condition, there is an urgent need to study the efficacy of atomoxetine on the different symptom domains of adult ADHD. To study the efficacy of atomoxetine in treating adult ADHD compared to placebo, we performed a Medline search for English language publications of Randomized Controlled Trials (RCTs) comparing atomoxetine to placebo for adult ADHD using the keywords "adult ADHD", "atomoxetine" and "placebo"...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931793/in-vitro-pharmacodynamic-evaluation-of-ceftolozane-tazobactam-against-%C3%AE-lactamase-producing-escherichia-coli-in-a-hollow-fibre-infection-model
#4
Rachel L Soon, Justin R Lenhard, Zackery P Bulman, Patricia N Holden, Pamela Kelchlin, Judith N Steenbergen, Lawrence V Friedrich, Alan Forrest, Brian T Tsuji
The proliferation of multidrug-resistant Gram-negative pathogens has been exacerbated by a lack of novel agents in current development by pharmaceutical companies. Ceftolozane/tazobactam was recently approved by the FDA for the treatment of complicated intra-abdominal infections and complicated urinary tract infections. In the present study, the activity of ceftolozane/tazobactam against four isogenic Escherichia coli strains was investigated in a hollow-fibre infection model simulating various clinical dosing regimens...
September 1, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27931719/a-potential-pitfall-in-evaluating-her2-immunohistochemistry-for-gastric-signet-ring-cell-carcinomas
#5
Chang Gok Woo, Won Jin Ho, Young Soo Park, Sook Ryun Park, Min-Hee Ryu, Hwoon-Yong Jung, Yoon-Koo Kang
Signet ring cell carcinoma (SRC) more commonly presents as metastatic disease and renders patients to be considered for chemotherapy. While treatment options are limited overall, trastuzumab has been shown to be effective for HER2 positive SRC cases. The current algorithm for HER2 evaluation heavily relies on positive membrane-specific staining by immunohistochemistry (IHC), but several anecdotal reports have suggested that SRCs may be susceptible to misinterpretation due to non-specific staining in the marginated cytoplasm with/without nucleus...
December 5, 2016: Pathology
https://www.readbyqxmd.com/read/27930986/plant-derived-flavone-apigenin-the-small-molecule-with-promising-activity-against-therapeutically-resistant-prostate-cancer
#6
REVIEW
Shabir Ahmad Ganai
Prostate cancer is the second leading cause of cancer related deaths in men in the United States. Mounting evidences suggest that in the pathophysiology of prostate cancer epigenetic modifications play a considerable role. Histone deacetylases (HDACs) have strong crosstalk with prostate cancer progression as they regulate various genes meant for tumour suppression. HDACs are emerging as striking molecular targets for anticancer drugs and therapy as their aberrant expression has been implicated in several cancers...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27930909/fda-regulation-of-neurological-and-physical-medicine-devices-access-to-safe-and-effective-neurotechnologies-for-all-americans
#7
Leigh Anderson, Patrick Antkowiak, Aden Asefa, Amber Ballard, Tushar Bansal, Ayo Bello, Bernard Berne, Kristen Bowsher, Bennett Blumenkopf, Ian Broverman, Mohamad Bydon, Kuo Chao, Peter Como, Karlene Cork, Ann Costello, Kathryn De Laurentis, Angela DeMarco, Heather Dean, John Doucet, Bradley Dworak, Lisa Epperson, Eric Franca, Naz Ghassemian, Chandramallika Ghosh, Anupama Govindarajan, Jay Gupta, Stacie Gutowski, Robert Herrmann, Michael Hoffmann, William Heetderks, Steven Hsu, Daryl Kaufman, Erin Keegan, Gregg Kittlesen, Kevin Khuu, Hyung Lee, Larry Lo, Ian Marcus, Timothy Marjenin, Binoy Mathews, Sanjay Misra, Vivek Pinto, Vesper Ramos, Samuel Raben, Avena Russell, Devjani Saha, Joonil Seog, Christian Shenouda, Myra Smith, Xiaorui Tang, Kelliann Wachrathit, Jaime Waterhouse, Dhanya Williams, Xiaolin Zheng, Carlos Peña
The United States Food and Drug Administration (FDA) ensures that patients in the U.S. have access to safe and effective medical devices. The Division of Neurological and Physical Medicine Devices reviews medical technologies that interface with the nervous system. This article addresses how to navigate the FDA's regulatory landscape to successfully bring medical devices to patients.
December 7, 2016: Neuron
https://www.readbyqxmd.com/read/27930873/preprogrammed-long-term-systemic-pulsatile-delivery-of-parathyroid-hormone-to-strengthen-bone
#8
Ming Dang, Amy J Koh, Theodora Danciu, Laurie K McCauley, Peter X Ma
Parathyroid hormone (PTH) is the only US Food and Drug Administration (FDA)-approved anabolic agent for the treatment of osteoporosis. The anabolic action of PTH depends on the mode of PTH administration. Pulsatile administration promotes bone formation, however continuous PTH exposure results in bone resorption. In addition, the therapeutic effect of PTH is optimal when the dose and duration fit the therapeutic window. Current PTH treatment requires daily injection, which is neither a convenient nor a favorable choice of patients...
December 8, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27929755/fda-approves-eteplirsen-for-duchenne-muscular-dystrophy-the-next-chapter-in-the-eteplirsen-saga
#9
Annemieke Aartsma-Rus, Arthur M Krieg
No abstract text is available yet for this article.
December 8, 2016: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/27929503/real-time-in-vivo-dosimetry-for-sbrt-prostate-treatment-using-plastic-scintillating-dosimetry-embedded-in-a-rectal-balloon-a-case-study
#10
Justin L Cantley, Chee-Wai Cheng, Fredrick B Jesseph, Tarun K Podder, Valdir C Colussi, Bryan J Traughber, Lee E Ponsky
A novel FDA approved in vivo dosimetry device system using plastic scintillating detectors placed in an endorectal balloon to provide real-time in vivo dosimetry for prostatic rectal interface was tested for use with stereotactic body radiotherapy (SBRT). The system was used for the first time ever to measure dose during linear accelerator based SBRT. A single patient was treated with a total dose of 36.25 Gy given in 5 fractions. Delivered dose was measured for each treatment with the detectors placed against the anterior rectal wall near the prostate rectal interface...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27929465/using-multi-fluorinated-bile-acids-and-in-vivo-magnetic-resonance-imaging-to-measure-bile-acid-transport
#11
Jessica Felton, Kunrong Cheng, Anan Said, Aaron C Shang, Su Xu, Diana Vivian, Melissa Metry, James E Polli, Jean-Pierre Raufman
Along with their traditional role as detergents that facilitate fat absorption, emerging literature indicates that bile acids are potent signaling molecules that affect multiple organs; they modulate gut motility and hormone production, and alter vascular tone, glucose metabolism, lipid metabolism, and energy utilization. Changes in fecal bile acids may alter the gut microbiome and promote colon pathology including cholerrheic diarrhea and colon cancer. Key regulators of fecal bile acid composition are the small intestinal Apical Sodium-dependent Bile Acid Transporter (ASBT) and fibroblast growth factor-19 (FGF19)...
November 27, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27929408/a-review-of-targeted-pulmonary-arterial-hypertension-specific-pharmacotherapy
#12
REVIEW
Ali Ataya, Jessica Cope, Hassan Alnuaimat
Significant advances in the understanding of the pathophysiology of pulmonary arterial hypertension over the past two decades have led to the development of targeted therapies and improved patient outcomes. Currently, a broad armamentarium of pulmonary arterial hypertension-specific drugs exists to assist in the treatment of this complex disease state. In this manuscript, we provide a comprehensive review of the current Food and Drug Administration (FDA)-approved pulmonary arterial hypertension-specific therapies, and their supporting evidence for adults, targeting the nitric oxide, soluble guanylate cyclase, endothelin, and prostacyclin pathways...
December 6, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27928947/oral-glucose-lowering-drugs-and-cardiovascular-outcomes-from-the-negative-record-and-accord-to-neutral-tecos-and-promising-empa-reg
#13
C Tsioufis, E Andrikou, C Thomopoulos, N Papanas, D Tousoulis
Cardiovascular (CV) morbidity and mortality are higher among patients with diabetes mellitus type 2 (T2DM), particularly those with concomitant CV diseases, compared with other populations. In patients with T2DM, intensive glucose lowering reduces microvascular disease, but has a smaller and debated effect on CV events or mortality. In this setting, the US Food and Drug Administration (FDA) required in 2008 that all new agents for the treatment of T2DM should be evaluated in terms of CV safety. Metformin has long been established as first-line pharmacological therapy in patients with T2DM, due to its proven beneficial CV effects...
December 8, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27928480/a-review-on-iron-chelators-in-treatment-of-iron-overload-syndromes
#14
REVIEW
Naser Mobarra, Mehrnoosh Shanaki, Hassan Ehteram, Hajar Nasiri, Mehdi Sahmani, Mohsen Saeidi, Mehdi Goudarzi, Hoda Pourkarim, Mehdi Azad
Iron chelation therapy is used to reduce iron overload development due to its deposition in various organs such as liver and heart after regular transfusion. In this review, different iron chelators implicated in treatment of iron overload in various clinical conditions have been evaluated using more up-to-date studies focusing on these therapeutic agents. Deferoxamine, Deferiprone and Deferasirox are the most important specific US FDA-approved iron chelators. Each of these chelators has their own advantages and disadvantages, various target diseases, levels of deposited iron and clinical symptoms of the afflicted patients which may affect their selection as the best modality...
October 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27928429/what-is-the-role-of-sipuleucel-t-in-the-treatment-of-patients-with-advanced-prostate-cancer-an-update-on-the-evidence
#15
REVIEW
Rachel Hu, Daniel J George, Tian Zhang
Prostate cancer is the most common cancer in men and the second most deadly. About one-third of patients with prostate cancer will develop metastatic disease. We discuss the six United States Food and Drug Administration (FDA) approved treatments for metastatic castrate-resistant prostate cancer (mCRPC) with a strong focus on sipuleucel-T. Sipuleucel-T is the first immunotherapy shown to improve survival in asymptomatic or minimally-symptomatic mCRPC. Herein, we discuss the proposed mechanism of sipuleucel-T and its synthesis...
August 2016: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/27928188/impact-of-the-fda-warning-for-azithromycin-and-risk-for-qt-prolongation-on-utilization-at-an-academic-medical-center
#16
Abby Dunker, Denise M Kolanczyk, Caitlin M Maendel, Amit R Patel, Natasha N Pettit
A US Food and Drug Administration (FDA) drug safety communication was released in March 2013, warning prescribers of the risk of QT prolongation associated with azithromycin. Overall azithromycin utilization and adherence to an inpatient QTc monitoring guideline during 8-month time periods before and after the warning were assessed to evaluate the impact of this warning on inpatient azithromycin utilization and QTc monitoring. Fifty-five patients were included in the prewarning time period and 50 were included in the postwarning period...
November 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27928184/ismp-adverse-drug-reactions-chronic-marijuana-use-associated-with-recurrent-diabetic-ketoacidosis-lamotrigine-induced-cataplexy-trimethoprim-sulfamethoxazole-induced-hyponatremia-ziprasidone-induced-sleepwalking-and-sleep-related-eating-metabolic-acidosis-associated
#17
Michael A Mancano
The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested...
November 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27927919/clinical-evaluation-and-cost-analysis-of-the-great-basin-shiga-toxin-direct-molecular-assay-for-the-detection-of-shiga-toxin-producing-escherichia-coli-stec-in-diarrheal-stool-specimens
#18
Matthew L Faron, Nathan A Ledeboer, Jessica Connolly, Paul A Granato, Brenda R Alkins, Jennifer Dien Bard, Judy A Daly, Stephen Young, Blake W Buchan
The Shiga Toxin Direct molecular assay (ST Direct) relies on nucleic acid amplification and solid array-based amplicon detection to identify Shiga toxin-encoding E. coli (STEC) in preserved stool specimens. Genes encoding Shiga toxin (stx1, stx2), as well as the E. coli serotype O:157-specific marker rfbE, are simultaneously detected within 2 hours. ST Direct was evaluated using 1,084 prospectively collected preserved stool specimens across five clinical centers. An additional 55 retrospectively collected, frozen specimens were included to increase the number of positive specimens evaluated...
December 7, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27927867/mastermind-bringing-microbial-diagnostics-to-the-clinic
#19
Robin Patel, Ephraim L Tsalik, Elizabeth Petzold, Vance G Fowler, Jeffrey D Klausner, Scott Evans
New diagnostics are urgently needed to address emerging antimicrobial resistance. The Antibacterial Resistance Leadership Group (ARLG) proposes a strategy called MASTERMIND (MASTER protocol for evaluating Multiple INfection Diagnostics) for advancement of infectious diseases diagnostics. The goal of this strategy is to generate the data necessary to support FDA clearance of new diagnostic tests by promoting research that might not have otherwise been feasible with conventional trial designs. MASTERMIND uses a single subject's sample(s) to evaluate multiple diagnostic tests at the same time, providing efficiencies of specimen collection and characterization...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27926889/precision-medicine-diabetes-and-the-u-s-food-and-drug-administration
#20
Robert J Meyer
The U.S. Food and Drug Administration (FDA) has long sought to achieve the broader use of personalized medicine, which is better targeting of FDA-approved therapies through incorporating precise knowledge of a patient's underlying condition to therapies optimally chosen to match those needs. While some strides have been made in precision medicine-particularly in oncology and rare genetic diseases-most of the standard general medicine indications have yet to realize the benefits of precision-guided therapies...
November 2016: Diabetes Care
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