keyword
https://read.qxmd.com/read/37382221/prevalence-of-hypercalcemia-in-primary-hypoadrenocorticism-in-dogs-multicenter-retrospective-study
#21
JOURNAL ARTICLE
Harriet Hall, Daniel Thompson, Jessica Florey, Mireia Pascual Moreno, Victoria Black, Timothy Williams, Barbara Skelly
BACKGROUND: Hypoadrenocorticism is an important differential for hypercalcemia. The etiology of hypercalcemia in hypoadrenocorticism in dogs is unclear. OBJECTIVE: To review the prevalence of hypercalcemia and use statistical models to identify clinical, demographic, and biochemical variables associated with hypercalcemia in dogs with primary hypoadrenocorticism. ANIMALS: One hundred ten dogs with primary hypoadrenocorticism; 107 with recorded total calcium (TCa), 43 recorded ionized calcium (iCa)...
June 29, 2023: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/37340686/adrenocortical-hypoperfusion-detected-by-contrast-enhanced-ultrasound-in-a-dog-with-trilostane-induced-hypoadrenocorticism
#22
N Nagata, K Aoshima, K Nakamura, M Takiguchi
A 12-year-old neutered male Chihuahua dog was diagnosed with pituitary-dependent hypercortisolism and treated with trilostane. Eighty-nine days later, the dog showed lethargy accompanied by hyponatraemia and hyperkalaemia. Hypoadrenocorticism due to trilostane was suspected, but the result of the adrenocorticotropic hormone stimulation test was not conclusive. Contrast-enhanced ultrasound showed loss of adrenocortical blood flow in both adrenal glands, indicating adrenocortical hypoperfusion and isolated hypoadrenocorticism...
June 20, 2023: Journal of Small Animal Practice
https://read.qxmd.com/read/37279885/urine-electrolytes-do-not-predict-desoxycorticosterone-pivalate-efficacy-in-dogs-with-hypoadrenocorticism
#23
JOURNAL ARTICLE
Daniel K Langlois, Casey A Dropkin, John M Kruger
OBJECTIVE: To determine if urine electrolyte assessments can be used to monitor the adequacy of mineralocorticoid therapy in dogs with hypoadrenocorticism (HA). ANIMALS: 29 dogs with naturally occurring glucocorticoid- and mineralocorticoid-deficient HA. PROCEDURES: Urine sodium and potassium concentrations, sodium-to-potassium ratios, sodium-to-creatinine ratios, and potassium-to-creatinine (K:Cr) ratios were evaluated in dogs with newly diagnosed HA that were treated with desoxycorticosterone pivalate (DOCP)...
June 10, 2023: American Journal of Veterinary Research
https://read.qxmd.com/read/37243803/neurological-and-endocrinological-involvement-in-neonatal-lupus-erythematosus-a-retrospective-study-at-a-tertiary-hospital-in-eastern-china
#24
JOURNAL ARTICLE
Wenqiang Sun, Li Ding, Mengzhao Li, Changchang Fu, Zihao Yang, Xueping Zhu
INTRODUCTION: Neonatal lupus erythematosus (NLE) is a rare autoimmune disease that causes transient impairment of multi-organ functions and is mainly caused by maternally transmitted antibodies. OBJECTIVE: This study aims to investigate the clinical features of infants with NLE, focusing on the presence of neurological and endocrinological involvement. METHODS: The clinical data of infants diagnosed with NLE at the Children's Hospital of Soochow University from 2011 to 2022 were collected and retrospectively analyzed...
May 27, 2023: Clinical Rheumatology
https://read.qxmd.com/read/37187927/case-report-recovery-and-sequential-imaging-of-a-patient-with-osmotic-demyelination-syndrome
#25
Stephanie Harris, Adrien Dupanloup, Pen-Ting Liao, Tom Jukier
A 4-year-old neutered-male Australian Shepherd was presented to an emergency and referral hospital for an acute onset of neurologic signs and abnormal mentation. Seven days prior, the patient had been diagnosed with hypoadrenocorticism and was treated accordingly at another hospital. Based on recent clinical history, the neurologic signs were consistent with thalamic and brainstem deficits and suspected to be caused by osmotic demyelination syndrome secondary to rapid correction of hyponatremia. A brain MRI confirmed lesions consistent with osmotic demyelination syndrome...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37183013/a-case-of-osteogenesis-imperfecta-caused-by-a-col1a1-variant-coexisting-with-pituitary-stalk-interruption-syndrome
#26
JOURNAL ARTICLE
Takuya Kitamura, Yuki Ishihara, Toru Kusakabe, Mika Tsuiki, Kazutaka Nanba, Kaho Hiroshima-Hamanaka, Takumi Nomura, Noriko Satoh-Asahara, Akihiro Yasoda, Tetsuya Tagami
Osteogenesis imperfecta (OI) is a rare hereditary bone fragility disorder that affects 6-7 per 100,000 populations, and pituitary stalk interruption syndrome (PSIS) is a rare congenital defect with varying degrees of pituitary hormone deficiency, affecting approximately 0.5 in every 100,000 births. Currently, only two cases of these complications have been reported. A 46-year-old male who had experienced more than 20 fractures (peripheral and vertebral) during adolescence visited our hospital for close examination...
May 12, 2023: Endocrine Journal
https://read.qxmd.com/read/37167252/2023-aaha-selected-endocrinopathies-of-dogs-and-cats-guidelines
#27
JOURNAL ARTICLE
Andrew Bugbee, Renee Rucinsky, Sarah Cazabon, Heather Kvitko-White, Patty Lathan, Amy Nichelason, Liza Rudolph
Canine and feline endocrinopathies reflect an endocrine gland disease or dysfunction with resulting hormonal abnormali ties that can variably affect the patient's wellbeing, quality of life, and life expectancy. These guidelines provide consensus recommendations for diagnosis and treatment of four canine and feline endocrinopathies commonly encountered in clini cal practice: canine hypothyroidism, canine hypercortisolism (Cushing's syndrome), canine hypoadrenocorticism (Addi son's disease), and feline hyperthyroidism...
May 1, 2023: Journal of the American Animal Hospital Association
https://read.qxmd.com/read/37138712/canine-hypoadrenocorticism-insights-into-the-addisonian-crisis
#28
JOURNAL ARTICLE
Nolan V Chalifoux, Hilary J Burgess, Cindy X Feng, Lyndsay R Kong, Elisabeth C R Snead
OBJECTIVE: Primary objectives of this study were to determine presenting complaints, physical examination, clinicopathologic findings, and hospitalization time of dogs with spontaneous hypoadrenocorticism presenting with critical disease; and to compare those end points to dogs with a more stable presentation. Secondary objectives were to evaluate the shock index and to identify precipitating stressors. ANIMALS: Eighty-four dogs at the Western College of Veterinary Medicine between 1998 and 2018 were included...
May 2023: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://read.qxmd.com/read/37083135/erratum-for-urinary-cortisol-creatinine-ratio-in-dogs-with-hypoadrenocorticism
#29
(no author information available yet)
No abstract text is available yet for this article.
April 21, 2023: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/37037658/diagnostic-predictivity-of-transtubular-potassium-gradient-for-primary-hypoadrenocorticism-in-hyperkalemic-dogs-a-cross-sectional-study
#30
JOURNAL ARTICLE
M Petini, M Drigo, M Caldin, A Zoia
OBJECTIVES: Transtubular potassium gradient has never been evaluated in the diagnosis of primary hypoadrenocorticism in dogs. The objective of this study is to evaluate the diagnostic utility of transtubular potassium gradient for the diagnosis of primary hypoadrenocorticism in dogs with serum K+  > 5.5 mol/L. MATERIALS AND METHODS: Cross-sectional study including dogs with primary hypoadrenocorticism and dogs with other disease. Differences in signalment and laboratory parameters between groups were assessed by binary logistic regression modelling...
April 10, 2023: Journal of Small Animal Practice
https://read.qxmd.com/read/36960837/iatrogenic-symptomatic-hypoadrenocorticism-after-treatment-with-trilostane-for-hyperadrenocorticism-in-dogs-eight-cases-2008-2019
#31
JOURNAL ARTICLE
A Lamoureux, J L Cadoré, M Hugonnard, L Chabanne, E Krafft
OBJECTIVES: Trilostane is the medical treatment of choice for hyperadrenocorticism. Iatrogenic hypoadrenocorticism is thought to be rare, with most cases being transient and only a few cases of permanent hypoadrenocorticism have been reported. This study reports findings from eight cases of iatrogenic hypoadrenocorticism and examines the presence of concurrent diseases at the time of diagnosis. MATERIALS AND METHODS: Medical records of dogs treated for hyperadrenocorticism with trilostane since 2008 were reviewed, and cases of clinical iatrogenic hypoadrenocorticism were extracted...
March 24, 2023: Journal of Small Animal Practice
https://read.qxmd.com/read/36809682/clinical-features-and-long-term-management-of-cats-with-primary-hypoadrenocorticism-using-desoxycorticosterone-pivalate-and-prednisolone
#32
JOURNAL ARTICLE
Nadja S Sieber-Ruckstuhl, Livia Harburger, Natalie Hofer, Claudia Kümmerle, Claudia Müller, Barbara Riond, Regina Hofmann-Lehmann, Claudia E Reusch, Felicitas S Boretti
BACKGROUND: Primary hypoadrenocorticism (PH) is rare in cats and knowledge about treatment is sparse. OBJECTIVE: To describe cats with PH with a focus on long-term treatment. ANIMALS: Eleven cats with naturally occurring PH. METHODS: Descriptive case series with data on signalment, clinicopathological findings, adrenal width, and doses of desoxycorticosterone pivalate (DOCP) and prednisolone during a follow-up period of >12 months...
March 2023: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/36755909/incidence-of-endocrine-related-immune-related-adverse-events-in-japanese-subjects-with-various-types-of-cancer
#33
JOURNAL ARTICLE
Yuichiro Iwamoto, Tomohiko Kimura, Hideyuki Iwamoto, Junpei Sanada, Yoshiro Fushimi, Yukino Katakura, Fuminori Tatsumi, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
BACKGROUND: Immune checkpoint inhibitors (ICIs), such as cytotoxic T lymphocyte antigen-4 (CTLA-4) inhibitors, programmed cell death protein 1 (PD-1) inhibitors, and programmed cell death protein 1 ligand 1 (PD-L1) inhibitors, are often used to treat a variety of malignancies. ICIs are known to cause endocrine-related immune-related adverse events (irAEs), but the incidence varies among reports and/or agents. This study evaluated the incidence of endocrine-related irAEs in patients who were treated with ICIs in Japan...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/36594371/assessment-of-a-compounded-synthetic-adrenocorticotropic-hormone-product-in-17-healthy-dogs
#34
JOURNAL ARTICLE
W Yang, G Hosgood, S Foster, K Langner, D Hayward, M Thompson
OBJECTIVES: Synthetic adrenocorticotropic hormone or tetracosactide is routinely used in the diagnosis of hypoadrenocorticism and frequently in the diagnosis and treatment of hyperadrenocorticism. There have been repeated shortages of tetracosactide in recent years in Australia. This study investigated the agreement of serum cortisol after a compounded tetracosactide (Bova Aus), compared to commercial tetracosactide (Synacthen®) in healthy dogs. METHODS: Prospective crossover study using 20 dogs...
January 3, 2023: Australian Veterinary Journal
https://read.qxmd.com/read/36523682/differentiating-immune-related-adrenal-insufficiency-from-low-cardiac-output-syndrome-a-case-report
#35
Junya Tanabe, Nobuhide Watanabe, Mayuna Ito, Keizo Kanasaki, Kazuaki Tanabe
We report a case of a 58-year-old woman with secondary adrenocortical insufficiency due to adrenocorticotropic hormone (ACTH) deficiency after pembrolizumab treatment that required differentiation from low cardiac output syndrome. The patient had chronic heart failure due to radiation cardiomyopathy and underwent implantation of cardiac resynchronization therapy defibrillator (CRT-D). One year ago, she was diagnosed with squamous cell lung cancer and started combination therapy with carboplatin, paclitaxel, and pembrolizumab...
November 2022: Curēus
https://read.qxmd.com/read/36458207/juvenile-hyperinsulinism-in-a-maine-coon-kitten
#36
Matthew Kornya, Anthony Abrams-Ogg, Dominique Comeau, Jeff Caswell
CASE SUMMARY: A 5.5 month-old intact male Maine Coon cat was presented to a referral hospital for a history of muscle fasciculations, lethargy and seizures associated with refractory hypoglycemia. Diagnostic testing for hypothyroidism, hyposomatotropism or hypoadrenocorticism, inborn errors of metabolism (ie, storage diseases and urea cycle disorders), infection or iatrogenic hypoglycemia were negative. An inappropriately high serum insulin level was noted in the face of marked hypoglycemia...
2022: JFMS Open Reports
https://read.qxmd.com/read/36439343/case-report-hypoadrenocorticism-crisis-complicated-by-non-cardiogenic-pulmonary-edema-in-a-dog
#37
Mathieu V Paulin, Elisabeth C Snead
A 6-year-old castrated male Labradoodle was referred in uncompensated hypovolemic shock, with a 72 - h history of lethargy, vomiting and diarrhea that had acutely worsened with subsequent development of profuse hemorrhagic diarrhea in the last 24 h after a visit to the groomer. In most respects this case was classic for a patient with a primary hypoadrenocortical crisis. After initial attempts to address hypovolemia and refractory hypotension, no clinical improvement was seen, and the respiratory rate had increased acutely to 80 bpm with crackles detected on thoracic auscultation and serosanguineous fluid began draining from the nose and mouth...
2022: Frontiers in Veterinary Science
https://read.qxmd.com/read/36398832/optimising-the-long-term-management-of-dogs-with-hypoadrenocorticism
#38
COMMENT
Katarina Hazuchova
No abstract text is available yet for this article.
November 2022: Veterinary Record
https://read.qxmd.com/read/36372430/atypical-hypoadrenocorticism-with-intact-zona-glomerulosa-of-the-adrenal-cortex-after-long-term-observation-a-case-report-of-a-dog
#39
JOURNAL ARTICLE
Shingo Hatoya, Ryoji Kanegi, Tomoyo Nabetani, Shoko Oji, Takeshi Izawa, Satoshi Hirai, Kikuya Sugiura
An 8-year-old intact male pointer presented with lethargy and hypoalbuminemia. On abdominal ultrasonography, both adrenal glands were reduced in thickness. Based on the ACTH stimulation test results and the absence of electrolyte abnormalities, the dog was diagnosed with atypical hypoadrenocorticism. After treatment with low-dose prednisolone, his general condition improved, and blood tests normalized. The dog died 818 days later, and a complete autopsy was performed. Histologically, the architecture of the zonae fasciculata and reticularis was disrupted in both adrenal glands; however, the zona glomerulosa remained relatively normal...
November 14, 2022: Journal of Veterinary Medical Science
https://read.qxmd.com/read/36369011/adrenocorticotropic-hormone-producing-pituitary-adenoma-with-pituitary-apoplexy-treated-by-surgical-decompression-a-case-report
#40
JOURNAL ARTICLE
Sachiyo Tanaka, Shuji Suzuki, Mana Oishi, Satoshi Soeta, Ryosuke Namiki, Yasushi Hara
BACKGROUND: Pituitary-dependent hypercortisolism (PDH) is one of the most common endocrine disorders in veterinary medicine. However, there are few reports on pituitary tumor apoplexy (PTA) in dogs and no reports on its surgical intervention in veterinary medicine. Accordingly, the appropriate treatment is unknown. Herein, a case of PDH and PTA in a dog treated surgically is described. CASE PRESENTATION: A mongrel female dog (spayed; age, 8 years and 8 months; weight, 6...
November 12, 2022: BMC Veterinary Research
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