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https://www.readbyqxmd.com/read/30097125/total-sesquiterpene-lactones-isolated-from-inula-helenium-l-attenuates-2-4-dinitrochlorobenzene-induced-atopic-dermatitis-like-skin-lesions-in-mice
#1
Qun Wang, Shuang Gao, Guo-Zhen Wu, Niao Yang, Xian-Peng Zu, Wen-Cai Li, Ning Xie, Rong-Rong Zhang, Chen-Wei Li, Zhen-Lin Hu, Wei-Dong Zhang
BACKGROUND: Inula helenium L. is an herb whose anti-inflammatory properties are attributed to its active components, the sesquiterpene lactones (SLs). Our previous study demonstrated that the total sesquiterpene lactones isolated from Inula helenium L. (TSL-IHL), consisting mainly of alantolactone (AL) and isoalantolactone (IAL), may have potential in the prevention and treatment of rheumatoid arthritis (RA). However, the effect of TSL-IHL on atopic dermatitis (AD) has not been studied yet...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30045259/effects-of-n-acetyl-cysteine-and-melatonin-on-early-reperfusion-injury-in-patients-undergoing-coronary-artery-bypass-grafting-a-randomized-open-labeled-placebo-controlled-trial
#2
RANDOMIZED CONTROLLED TRIAL
Ebrahim Shafiei, Mehrzad Bahtoei, Pema Raj, Afshin Ostovar, Daryoush Iranpour, Samad Akbarzadeh, Hooshang Shahryari, Abdorasoul Anvaripour, Rahim Tahmasebi, Thomas Netticadan, Ali Movahed
OBJECTIVES: This study assessed the efficacy of oral consumption of N-acetyl cysteine (NAC) and melatonin (ML) in reducing early reperfusion injury and acute oxidative stress in patients undergoing coronary artery bypass grafting (CABG) with respect to the measurements of cardiac troponin I, lactate, malondealdehyde (MDA), and tumor necrosis factor-α (TNF-α) levels in the blood. METHODS: This study was a randomized, open-label, placebo-controlled trial. Eighty eight patients, aged between 39 to 76 years and eligible for CABG, were recruited and randomly assigned into 3 intervention groups through a simple randomization method and underwent CABG surgery...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30032348/traumatic-cardiac-arrest-and-resuscitative-endovascular-balloon-occlusion-of-the-aorta-reboa-a-preliminary-analysis-utilizing-high-fidelity-invasive-blood-pressure-recording-and-videography
#3
Philip J Wasicek, Shiming Yang, William A Teeter, Peter Hu, Deborah M Stein, Thomas M Scalea, Megan L Brenner
PURPOSE: Aortic occlusion (AO) increases proximal perfusion and may improve rates of return of spontaneous circulation (ROSC). The objective of this study was to investigate the hemodynamic effects of cardiopulmonary resuscitation (CPR) and AO by REBOA on patients in traumatic cardiac arrest. METHODS: Patients admitted between February 2013 and May 2017 at a tertiary center who suffered traumatic arrest, had an arterial line placed during resuscitation, and received CPR and REBOA which were included...
July 21, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/30031357/a-novel-technique-to-establish-hemodynamic-monitoring-in-patients-supported-with-extracorporeal-life-support-systems-ecls-for-cardiopulmonary-resuscitation-ecpr
#4
Dirk Lunz, Alois Philipp, Christoph Birner
PURPOSE: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used to support conventional unsuccessful resuscitation and it is mandatory to rapidly initiate invasive hemodynamic monitoring, as soon as ECPR therapy is commenced. Commonly, this is achieved by establishing an additional arterial line via the right radial artery for invasive blood pressure measurement, but this can be challenging and risky on the one hand and might lead to erroneous measurements on the other hand...
July 17, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/30031055/chest-compression-rates-and-pediatric-in-hospital-cardiac-arrest-survival-outcomes
#5
Robert M Sutton, Ron W Reeder, William Landis, Kathleen L Meert, Andrew R Yates, John T Berger, Christopher J Newth, Joseph A Carcillo, Patrick S McQuillen, Rick E Harrison, Frank W Moler, Murray M Pollack, Todd C Carpenter, Daniel A Notterman, Richard Holubkov, J Michael Dean, Vinay M Nadkarni, Robert A Berg
AIM: The primary aim of this study was to evaluate the association between chest compression rates and 1) arterial blood pressure and 2) survival outcomes during pediatric in-hospital cardiopulmonary resuscitation (CPR). METHODS: Prospective observational study of children ≥37 weeks gestation and <19 years old who received CPR in an intensive care unit (ICU) as part of the Pediatric Intensive Care Unit Quality of CPR Study (PICqCPR) of the Collaborative Pediatric Critical Care Research Network (CPCCRN)...
September 2018: Resuscitation
https://www.readbyqxmd.com/read/30013612/the-reliability-of-carotid-ultrasound-in-determining-the-return-of-pulsatile-flow-a-pilot-study
#6
Biljana Germanoska, Matthew Coady, Sheyin Ng, Gary Fermanis, Matthew Miller
Manual palpation of pulses is unreliable in detecting pulsatile flow in human participants, complicating the assessment of return of spontaneous circulation after cardiac arrest. Ultrasound may offer an alternative. This study's objective was to investigate whether return of pulsatile flow in humans can be reliably assessed by common carotid artery ultrasound. We conducted a single-blinded randomised study of common carotid artery ultrasound using 20 cardiopulmonary bypass patients to model the return of pulsatile flow...
May 2018: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/30013035/isoalantolactone-suppresses-lps-induced-inflammation-by-inhibiting-traf6-ubiquitination-and-alleviates-acute-lung-injury
#7
Yun-He Ding, Yun-Duan Song, Ya-Xian Wu, Hui-Qiong He, Tian-Hong Yu, Yu-Dong Hu, De-Peng Zhang, Hong-Chao Jiang, Kai-Kai Yu, Xiao-Zong Li, Lei Sun, Feng Qian
Isoalantolactone (IAL) is a sesquiterpene lactone extracted from roots of Inula helenium L and has shown anti-inflammatory effects. In this study we investigated the therapeutic effects of IAL on acute lung injury (ALI) and elucidated the mechanisms underlying its anti-inflammation potential in vitro and in vivo. Treatment with lipopolysaccharide (LPS, 100 ng/mL) drastically stimulated production of inflammatory mediators such as NO, TNF-α, IL-1β, and IL-6 in mouse bone marrow-derived macrophages (BMDMs), which was dose-dependently suppressed by pretreatment with IAL (2...
July 16, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29992978/estimation-of-cardiovascular-risk-predictors-from-non-invasively-measured-diametric-pulse-volume-waveforms-via-multiple-measurement-information-fusion
#8
Zahra Ghasemi, Jong Chan Lee, Chang-Sei Kim, Hao-Min Cheng, Shih-Hsien Sung, Chen-Huan Chen, Ramakrishna Mukkamala, Jin-Oh Hahn
This paper presents a novel multiple measurement information fusion approach to the estimation of cardiovascular risk predictors from non-invasive pulse volume waveforms measured at the body's diametric (arm and ankle) locations. Leveraging the fact that diametric pulse volume waveforms originate from the common central pulse waveform, the approach estimates cardiovascular risk predictors in three steps by: (1) deriving lumped-parameter models of the central-diametric arterial lines from diametric pulse volume waveforms, (2) estimating central blood pressure waveform by analyzing the diametric pulse volume waveforms using the derived arterial line models, and (3) estimating cardiovascular risk predictors (including central systolic and pulse pressures, pulse pressure amplification, and pulse transit time) from the arterial line models and central blood pressure waveform in conjunction with the diametric pulse volume waveforms...
July 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29992507/can-variable-practice-habits-and-injection-port-dead-volume-put-patients-at-risk
#9
Michael T Kuntz, Roman Dudaryk, Richard R McNeer
Injection ports used to administer medications and draw blood samples have inherent dead-volume. This volume can potentially lead to inadvertent drug administration, contribute to erroneous laboratory values by dilution of blood samples, and increase the risk of vascular air embolism. We sought to characterize provider practice in management of intravenous (IV) and arterial lines and measure dead-volumes of various injection ports. A survey was circulated to anesthesiology physicians and nurses to determine practice habits when administering medications and drawing blood samples...
July 10, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29910503/modification-of-intravenous-cannula-for-arterial-line-insertion-simple-yet-effective-technique
#10
Ashutosh Kaushal, Ashish Bindra, Shalendra Singh, Zakia Saeed
No abstract text is available yet for this article.
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29906636/antimicrobial-sensitivity-trends-and-virulence-genes-in-shigella-spp-from-the-oceania-region
#11
Elisheba Malau, Rebecca Ford, Mary Valcanis, Amy V Jennison, Jenny Mosse, David Bean, Mition Yoannes, William Pomat, Paul F Horwood, Andrew R Greenhill
Shigella is a common cause of diarrhoea in Papua New Guinea (PNG) and other Oceania countries. However, little is known about the strains causing infection. Archived Shigella isolates (n = 72) were obtained from research laboratories in PNG and reference laboratories in Australia. Shigella virulence genes were detected by PCR, and antimicrobial susceptibility was determined by disk diffusion. The ipaH virulence gene was present in all 72 isolates. The prevalence of other virulence genes was variable, with ial, invE, ipaBCD, sen/ospD3 and virF present in 60% of isolates and set1A and set1B genes present in 42% of isolates...
June 12, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29879965/molecular-characterization-of-fluoroquinolone-and-or-cephalosporin-resistance-in-shigella-sonnei-isolates-from-yaks
#12
Zhen Zhu, Yuxiang Shi, Xuzheng Zhou, Bing Li, Jiyu Zhang
BACKGROUND: Members of the genus Shigella are intestinal pathogens and a major cause of seasonal outbreaks of bacterial diarrhea worldwide. Although humans are the conventional hosts of Shigella species, expansion of the Shigella host range to certain animals was recently reported. To investigate the prevalence of Shigella sonnei (S. sonnei) in yaks and perform molecular characterization, we analyzed 1132 fresh yak diarrheal stool samples and collected a total of 44 S. sonnei isolates...
June 7, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29878102/sedation-strategies-for-defibrillation-threshold-testing-safety-outcomes-with-anaesthesiologist-compared-to-proceduralist-directed-sedation-an-analysis-from-the-simple-study
#13
Roopinder K Sandhu, Kenneth K Quadros, Yan Yun Liu, Michael Glikson, Valentina Kutyifa, Phillipe Mabo, Stefan Hohnloser, Gilles O'Hara, Liselot VanErven, Jorg Neuzner, Josef Kautzner, Frederik Gadler, Xavier Vinolas, Ursula Appl, Stuart J Connolly, Jeff S Healey
Aims: No standard practice exists with respect to anaesthesiologist-directed sedation (ADS) vs. sedation by proceduralist (PDS) for defibrillation threshold (DT) testing. We aimed to evaluate adverse events and safety outcomes with ADS vs. PDS for DT testing. Methods and results: A post hoc analysis of the Shockless Implant Evaluation (SIMPLE) study was performed among the 1242 patients who had DT testing (624 ADS and 618 PDS). We evaluated both intraoperative and in-hospital adverse composite events and two safety composite outcomes at 30-days of the main trial...
June 6, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29869762/error-checking-intraoperative-arterial-line-blood-pressures
#14
Charles Huanghong Du, David Glick, Avery Tung
Electronic medical records now store a wealth of intraoperative hemodynamic data. However, analysis of such data is plagued by artifacts related to the monitoring environment. Here, we present an algorithm for automated identification of artifacts and replacement using interpolation of arterial line blood pressures. After IRB approval, minute-by-minute digital recordings of systolic, diastolic, and mean arterial pressures (MAP) obtained during anesthesia care were analyzed using predetermined metrics to identify values anomalous from adjacent neighbors...
June 5, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29780973/case-report-transection-of-radial-arterial-catheter-requiring-surgical-intervention
#15
Luis Tollinche, Jacob Jackson, Melvin La, Dawn Desiderio, Cindy Yeoh
We report a case in which a radial arterial line was placed prior to induction of general anaesthesia in a 76 year old male with prostate cancer and multiple co-morbidities who presented for thoracoscopic resection of a right lower lobe carcinoid lung tumor. The patient's intra-operative course was complicated by acute blood loss requiring conversion to an open procedure. A subsequent injury to the superior vena cava resulted in the need for immediate re-exploration at the conclusion of surgery. While the arterial line was still indicated in this patient's postoperative course in the ICU, malfunction on post-operative day one resulted in removal of the catheter...
2018: Journal of Intensive and Critical Care
https://www.readbyqxmd.com/read/29779129/practical-impact-of-a-decision-support-for-goal-directed-fluid-therapy-on-protocol-adherence-a-clinical-implementation-study-in-patients-undergoing-major-abdominal-surgery
#16
Alexandre Joosten, Reda Hafiane, Marco Pustetto, Luc Van Obbergh, Thierry Quackels, Alexis Buggenhout, Jean-Louis Vincent, Brigitte Ickx, Joseph Rinehart
The purpose of this study was to assess the effects of using a real time clinical decision-support system, "Assisted Fluid Management" (AFM), to guide goal-directed fluid therapy (GDFT) during major abdominal surgery. We compared a group of patients managed using the AFM system with a historical cohort of patients (control group) who had been managed using a manual GDFT strategy. Adherence to the protocol was defined as the relative intraoperative time spent with a stroke volume variation (SVV) < 13%...
May 19, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29775559/mechanosensitivity-of-mitochondrial-large-conductance-calcium-activated-potassium-channels
#17
Agnieszka Walewska, Bogusz Kulawiak, Adam Szewczyk, Piotr Koprowski
Potassium channels have been discovered in the inner mitochondrial membrane of various cells. These channels can regulate the mitochondrial membrane potential, the matrix volume, respiration and reactive species generation. Therefore, it is believed that their activation is cytoprotective in various tissues. In our study, the single-channel activity of a large-conductance calcium-activated potassium channel (mitoBKCa ) was measured by the patch-clamp technique on mitoplasts derived from mitochondria isolated from human glioma U-87 MG cells...
May 24, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29735381/escherichia-coli-isolates-from-patients-with-inflammatory-bowel-disease-expec-virulence-and-colicin-determinants-are-more-frequent-compared-to-healthy-controls
#18
Lenka Micenková, Lucia Frankovičová, Iva Jaborníková, Juraj Bosák, Petr Dítě, Jan Šmarda, Martin Vrba, Alena Ševčíková, Marta Kmeťová, David Šmajs
A set of 178 Escherichia coli isolates taken from patients with inflammatory bowel disease (IBD) was analyzed for bacteriocin production and tested for the prevalence of 30 bacteriocin and 22 virulence factor determinants. Additionally, E. coli phylogenetic groups were also determined. Pulsed-field gel electrophoresis (PFGE) was used for exclusion of clonal character of isolates. Results were compared to data from a previously published analysis of 1283 fecal commensal E. coli isolates. The frequency of bacteriocinogenic isolates (66...
July 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29734257/noninvasive-measures-of-pulsatility-and-blood-pressure-during-continuous-flow-left-ventricular-assist-device
#19
Sabarivinoth Rangasamy, Shivank Madan, Omar Saeed, Daniel J Goldstein, Ulrich P Jorde, Abdissa Negassa, Snehal R Patel
The reliability and validity of a palpable pulse and other noninvasive measures of pulsatility in patients on continuous-flow (CF) left ventricular assist device (LVAD) support have not been rigorously evaluated. We prospectively enrolled 23 patients who had CF-LVAD and an arterial catheter for blood pressure (BP) monitoring. Pulse pressure (PP) via the arterial line was compared with three noninvasive measures of pulsatility: presence of a palpable pulse, pulsatility index (PI), and aortic valve opening (AVO)...
April 19, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29685512/causes-and-outcomes-of-finger-ischemia-in-hospitalized-patients-in-the-intensive-care-unit
#20
Gregory J Landry, Courtney J Mostul, Daniel S Ahn, Bryant J McLafferty, Timothy K Liem, Erica L Mitchell, Enjae Jung, Cherrie Z Abraham, Amir F Azarbal, Robert B McLafferty, Gregory L Moneta
OBJECTIVE: Vascular surgeons may be consulted to evaluate hospitalized patients with finger ischemia. We sought to characterize causes and outcomes of finger ischemia in intensive care unit (ICU) patients. METHODS: All ICU patients who underwent evaluation for finger ischemia from 2008 to 2015 were reviewed. All were evaluated with finger photoplethysmography. The patients' demographics, comorbidities, ICU care (ventilator status, arterial lines, use of vasoactive medications), finger amputations, and survival were also recorded...
April 20, 2018: Journal of Vascular Surgery
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