Anna Vulpetti, Jean-Michel Rondeau, Marie-Hélène Bellance, Jutta Blank, Ralf Boesch, Andreas Boettcher, Frédéric Bornancin, Sylvia Buhr, Lauren E Connor, Christoph E Dumelin, Oliver Esser, Michael Hediger, Samuel Hintermann, Ulrich Hommel, Elke Koch, Guillaume Lapointe, Lukas Leder, Sylvie Lehmann, Philipp Lehr, Peter Meier, Lionel Muller, Daniela Ostermeier, Paul Ramage, Sihame Schiebel-Haddad, Alexander Baxter Smith, Aleksandar Stojanovic, Juraj Velcicky, Rina Yamamoto, Konstanze Hurth
Human interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a critical role in the regulation of the immune response and the development of various inflammatory diseases. In this publication, we disclose our efforts toward the discovery of IL-1β binders that interfere with IL-1β signaling. To this end, several technologies were used in parallel, including fragment-based screening (FBS), DNA-encoded library (DEL) technology, peptide discovery platform (PDP), and virtual screening...
May 10, 2024: Journal of Medicinal Chemistry