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"Acute Coronary Syndrome" OR "ACS"

Marija Vavlukis, Biljana Zafirovska, Emilija Antova, Bekim Pocesta, Enes Shehu, Hajber Taravari, Irena Kotlar, Darko Kitanovski, Danica Petkoska, Ivan Vasilev, Filip Janusevski, Ivica Bojovski, Sashko Kedev
No abstract text is available yet for this article.
July 1, 2018: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
Avishay Elis, David Pereg, Zaza Iakobishvili, Dikla Geva, Ilan Goldenberg
BACKGROUND: A patient`s individual chance of being diagnosed with cardiovascular disease can be determined by risk scores. OBJECTIVES: To determine the risk score profiles of patients presenting with a first acute coronary event according to pre-admission risk factors and to evaluate its association with long-term mortality. METHODS: The research was based on a retrospective study of a cohort from the 2010 and 2013 Acute Coronary Syndrome Israeli Surveys (ACSIS)...
July 2018: Israel Medical Association Journal: IMAJ
P Ravichandran, P Sugumaran, S Seshadri, Altaf H Basta
This work deals with optimizing the conditions of pyrolysis and type of activator to upgrade the use of Casuarina equisetifolia fruit waste (CFW) as available and a potential precursor, in production of activated carbon (AC). In this respect, the route of activation was carried out through one- and two-step pyrolysis processes, using different chemical activating agents, such as H3 PO4 , KOH and ZnCl2 . The performance of the CFW-based ACs is assessed by estimating the physico-chemical characteristics (pH, electrical conductivity, bulk density and hardness), surface morphology and scanning electron microscopy, together with carbon yield, surface area and adsorption performance of pollutants in aqueous medium (methylene blue, iodine and molasses colour removal efficiencies)...
July 2018: Royal Society Open Science
Apirak Sribhutorn, Arintaya Phrommintikul, Wanwarang Wongcharoen, Usa Chaikledkaew, Suntara Eakanunkul, Apichard Sukonthasarn
Background: Influenza vaccination has been clinically shown to reduce adverse cardiovascular outcomes in acute coronary syndrome (ACS) patients, but the economic perspectives can provide important data to make informed decisions. This study aimed to perform the economic evaluation of lifelong annual influenza vaccination for cardiovascular events and well-established pneumonia prevention. Methods: Lifetime costs, life-expectancy, and quality-adjusted live years (QALYs) were estimated beyond one-year cycle length of a six-health states Markov model condition on whether a hospitalization for ACS, stroke, heart failure, pneumonia, no hospitalizations occurred, or death...
June 2018: Journal of Geriatric Cardiology: JGC
Lindsay A Sobotka, Syed G Husain, Somashekar G Krishna, Alice Hinton, Ravi Pavurula, Darwin L Conwell, Cheng Zhang
INTRODUCTION: The Center for Medicare and Medicaid Services established 30-day readmission rate as a key metric in measuring high-value, cost-conscious care; therefore, our aim is to develop a risk score for 30-day readmission in ulcerative colitis (UC) patients undergoing colectomy or proctectomy. METHODS: This study used data from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) participant user file (2011-2015). Patients with UC undergoing colectomy or proctectomy were identified using ICD-9, 10, and CPT codes...
August 15, 2018: Clinical and Translational Gastroenterology
Antonio Maria Leone, Pio Cialdella, Francesca Lassandro Pepe, Eloisa Basile, Giuseppe Zimbardo, Manfredi Arioti, Giovanna Ciriello, Domenico D'Amario, Antonino Buffon, Francesco Burzotta, Italo Porto, Cristina Aurigemma, Giampaolo Niccoli, Antonio G Rebuzzi, Carlo Trani, Filippo Crea
BACKGROUND: Fractional Flow Reserve (FFR) in Stable Ischemic Heart Disease (SIHD) is universally accepted, while in Acute Coronary Syndromes (ACS) is less established. Aims of this retrospective study were: to compare in patients undergoing FFR assessment the prognostic impact of ACS vs SIHD, to evaluate the clinical relevance of the modality of utilization and timing of FFR assessment and to assess the different outcomes associated with an FFR> or ≤0.80. METHODS: Major cardiac adverse events were assessed at a follow up of 16...
August 9, 2018: International Journal of Cardiology
Pablo Lamelas, J D Schwalm, Darryl Leong, Sanjit Jolly, Shamir Mehta, Shrikant Bangdiwala, Salim Yusuf
It is unclear why high body mass index (BMI) is associated with a lower risk of death in patients with cardiovascular disease (CVD). We hypothesized that the impact of higher BMI varies by the patient's baseline risk of death. We analyzed data from 14 prospective studies conducted by us in 50 countries of 170,470 patients: 22.8% without CVD, 29.4% with stable CVD and 47.8% with acute coronary syndromes (ACS). Compared with overweight (BMI 25 to 29.9 kg/m2 ), normal weight (BMI 20 to 24.9 kg/m2 ), and underweight (BMI < 20 kg/m2 ) were associated with higher mortality in all cohorts...
July 4, 2018: American Journal of Cardiology
Nathaniel A Erskine, Barbara Gandek, Hoang V Tran, Hawa Abu, David D McManus, Catarina I Kiefe, Robert J Goldberg
Little is known about how barriers to healthcare access affect health-related quality of life (HRQOL) after an acute coronary syndrome (ACS). In a large cohort of ACS survivors from 6 medical centers in Massachusetts and Georgia enrolled from 2011 to 2013, patients were classified as having any financial barriers, no usual source of care (USOC), or transportation barriers to healthcare based on their questionnaire survey responses. The principal study outcomes included clinically meaningful declines in generic physical and mental HRQOL and in disease-specific HRQOL from 1 to 6 months posthospital discharge...
August 11, 2018: American Journal of Cardiology
Saleema Allana, Dr Debra K Moser, Dr Tazeen Saeed Ali, Dr Aamir Hameed Khan
BACKGROUND: Patients' experience of acute coronary syndrome (ACS) symptoms is important in determining their prehospital delay. OBJECTIVE: To explore gender differences in acute symptoms of ACS, knowledge about the symptoms, their attribution, and perception of urgency, among Pakistani ACS patients. METHODS: Comparative, cross-sectional study design with 249 ACS patients. RESULTS: The most commonly reported symptoms were ghabrahat (fidgetiness), chest pain, and chest heaviness...
August 11, 2018: Heart & Lung: the Journal of Critical Care
Yusuke Watanabe, Toru Naganuma, Yosuke Kitanaka, Sunao Nakamura
A 70-year-old woman with substernal chest pain lasting 2.5 h presented to the emergency department of our hospital. She had a history of aortic valve replacement with the Freestyle stentless aortic bioprosthesis for severe aortic regurgitation 7 years ago. The initial electrocardiogram showed sinus rhythm at a rate of 71 bpm with ST-segment slight elevation in leads II, III and aVF. She was diagnosed as having acute coronary syndrome and was referred for an urgent catheterization. Urgent coronary angiography revealed total occlusion in the distal segment of the right coronary artery...
August 10, 2018: European Journal of Cardio-thoracic Surgery
Mazlum Sahin, Semi Öztürk, Tugba I Mert, Gündüz Durmuş, Mehmet Mustafa Can
OBJECTIVE: To assess  outcomes of Syrian refugees undergoing coronary artery bypass surgery in a tertiary hospital in Turkey. METHODS:  We sought for in-hospital mortality and one year all-cause mortality as the main outcomes. We reviewed records of 67 Syrian and 427 Turkish patients undergoing isolated coronary bypass surgery between 2015 January and 2017 January retrospectively.  Results: History of coronary, peripheral and carotid artery diseases and obesity were more frequent in Syrian patients...
July 2018: Saudi Medical Journal
Ahmet Guner, Alev Kılıcgedik, Macit Kalçık, Mehmet Ozkan
Coronary embolism (CE) is the underlying cause of 3% of acute coronary syndromes but is frequently overlooked in the differential diagnoses of acute coronary syndromes. The CE may be direct (left sided from the native or prosthetic heart valve, the left atrium, left atrial appendage or pulmonary venous bed), paradoxical (from the venous circulation through a patent foramen ovale, atrial septal defect, ventricular septal defects, cyanotic congenital heart defects or pulmonary arteriovenous malformations), or iatrogenic (following cardiac interventions...
August 13, 2018: Echocardiography
Johannes Leschik, Timm Bauer
No abstract text is available yet for this article.
August 2018: MMW Fortschritte der Medizin
Józef Bergier, Anatolii Tsos, Dariya Popovych, Barbara Bergier, Ewelina Niźnikowska, Pongrác Ács, Jan Junger, Ferdinand Salonna
Background : Examining the level of physical activity in students is a vital issue as these young people are the future social elite. Methods : The research was conducted in the years 2013⁻2016 and comprised 5008 males and females, mean age of 20.5 ± 2.1 years, including 2237 (55.3%) students from students from Eastern European National University, Lutsk, and Ternopil State Medical University, Ukraine, as well as 2237 (44.7%) from the Visegrad countries, i.e., University of Pécs in Hungary, University in Kosice, Slovakia, University of Olomunec in the Czech Republic and the State School of Higher Education in Biała Podlaska, Poland...
August 13, 2018: International Journal of Environmental Research and Public Health
Giovanna Lucchini, Rebecca Marsh, Kimberly Gilmour, Austen Worth, Zohreh Nademi, Anupama Rao, Claire Booth, Persis Amrolia, Juliana Silva, Robert Chiesa, Robert Wynn, Kai Lehmberg, Itziar Astigarraga, Tayfun Gungor, Jan Stary, Despina Moshous, Marianne Ifversen, Daniel Zinn, Michael Jordan, Ashish Kumar, Takahiro Yasumi, Paul Veys, Kanchan Rao
Asymptomatic carriers of pathogenic bilallelic mutations in causative genes for primary haemophagocytic lymphohistiocytosis (HLH) are at high-risk of developing life-threatening HLH, which requires allogeneic haematopoietic stem cell transplantation (HSCT) to be cured. There are no guidelines on the management of these asymptomatic patients. We analysed the outcomes of pairs of index cases (ICs) and subsequently diagnosed asymptomatic family members (ACs) carrying the same genetic defect. We collected data from 22 HSCT Centres worldwide...
August 13, 2018: Blood
Uwe Zeymer, Benedikt Schrage, Dirk Westermann
The optimal anti-thrombotic therapy for secondary prevention after an acute coronary syndrome is still a matter of debate. While current guidelines recommend dual anti-platelet therapy with aspirin and a P2Y12 inhibitor over 12 months especially in patients with stent implantation, the value of prolonged anticoagulation is still controversial. In the ATLAS-TIMI 52 trial, a low-dose direct factor Xa inhibition with rivaroxaban compared with placebo reduced the combined primary endpoint of cardiovascular mortality, myocardial infraction and stroke with an increase in major bleeding complications...
August 13, 2018: Thrombosis and Haemostasis
Bashar Hannawi, Yousef Hannawi, Neal S Kleiman
Platelets play an essential role in the pathophysiology of atherothrombosis. Reticulated platelets (RPs) are the youngest platelet population in the circulation; their presence is an indicator of platelet turnover. Circulating levels of RPs are increased in patients with coronary artery disease and stroke. Preliminary indications are that the proportion of circulating RP is associated with the likelihood of ischaemic events such as acute coronary syndrome and stroke. Plausible mechanisms include: (1) increased participation of these platelets in thrombosis due to messenger ribonucleic acid that may be translated to active proteins, (2) lack of exposure to anti-platelet drugs since they are newly released from the bone marrow or (3) their presence is a non-specific marker of inflammation...
August 13, 2018: Thrombosis and Haemostasis
Lisa Gross, Dietmar Trenk, Claudius Jacobshagen, Anne Krieg, Meinrad Gawaz, Steffen Massberg, Monika Baylacher, Daniel Aradi, Fabian Stimpfle, Julia Hromek, Anja Vogelgesang, Martin Hadamitzky, Dirk Sibbing, Tobias Geisler
BACKGROUND:  Phenotype-guided de-escalation (PGDE) of P2Y12 -inhibitor treatment with an early switch from prasugrel to clopidogrel was identified as an effective alternative treatment strategy in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). The Testing Responsiveness to Platelet Inhibition on Chronic Antiplatelet Treatment for Acute Coronary Syndromes (TROPICAL-ACS) Genotyping Substudy aimed to investigate whether CYP2C19 genotypes correlate with on-treatment platelet reactivity (PR) in ACS patients treated with clopidogrel or prasugrel and thus might be useful for guidance of early de-escalation of anti-platelet treatment...
August 13, 2018: Thrombosis and Haemostasis
Kaarjel K Narayanasamy, Melissa Cruz-Acuña, Carlos Rinaldi, James Everett, Jon Dobson, Neil D Telling
HYPOTHESIS: The functionality of magnetic nanoparticles (MNPs) relies heavily on their surface coating, which in turn affects the interactions between MNPs, and the formation of single-core particles or multi-core clusters. In this study we assessed the use of AC susceptibility (ACS) as a magnetic probe of the kinetics of coating and agglomeration of functionalised nanoparticles. We demonstrate the precision and sensitivity of ACS measurements to small changes in MNP coating using arginine-glycine-aspartic acid (RGD) tripeptide binding, and subsequently discuss how ACS can be used to optimise the preparation of polyethyleneimine (PEI) functionalised MNPs aimed at nanomagnetic transfection applications...
August 7, 2018: Journal of Colloid and Interface Science
Udaya Tantry, Rahul Chaudhary, Jacek Kubica, Kevin Bliden, Paul A Gurbel
All oral P2Y12 receptor blockers are associated with some degree of delayed onset and offset of pharmacodynamic (PD) effects in patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention (PCI). Although intravenous glycoprotein IIb/IIIa inhibitors are associated with rapid onset of action, they are also associated with delayed offset and other limitations such as elevated bleeding risk and thrombocytopenia. Areas covered: In this review, the authors focus on cangrelor, an intravenous, reversible P2Y12 receptor blocker with fast onset and offset of effects...
August 13, 2018: Expert Opinion on Pharmacotherapy
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