Ellen L Risemberg, Johanna M Smeekens, Marta C Cruz Cisneros, Brea K Hampton, Pablo Hock, Colton L Linnertz, Darla R Miller, Kelly Orgel, Ginger D Shaw, Fernando Pardo Manuel de Villena, A Wesley Burks, William Valdar, Michael D Kulis, Martin T Ferris
BACKGROUND: The development of peanut allergy is due to a combination of genetic and environmental factors, although specific genes have proven difficult to identify. Previously, we reported that peanut-sensitized CC027/GeniUnc (CC027) mice develop anaphylaxis upon oral challenge to peanut, unlike C3H/HeJ (C3H) mice. OBJECTIVE: To determine the genetic basis of orally-induced anaphylaxis to peanut in CC027 mice. METHODS: A genetic mapping population between CC027 and C3H mice was designed to identify the genetic factors that drive oral anaphylaxis...
April 24, 2024: Journal of Allergy and Clinical Immunology