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"Anaphylaxis" OR "Anaphylactic Shock" OR "Severe Allergic Reaction"

Miki Nagashima, Madoka Koyanagi, Yutaka Arimura
Allergic diseases have increased in the last three decades. Mast cells play a critical role in allergic diseases along with allergen-specific immunoglobulin E (IgE). Following mast cell degranulation elicited by ligation of the IgE-FcεRI receptor complex with allergen, allergic reactions are followed by various symptoms such as vascular hyperpermeability, mucous secretion, itching, sneezing, wheezing, rashes, fever, and anaphylactic shock. Susceptibility or inclination to allergy varies depending on individual genetic traits and living environment, and it has long been believed that such an inclination is determined by an immunologic balance of T helper cell types...
October 18, 2018: Immunological Investigations
Dong Hyun Kim, Eunae Cho, Sung Bum Cho, Sung Kyu Choi, Sunmin Kim, Jieun Yu, Young-Il Koh, Da Woon Sim, Chung Hwan Jun
RATIONALE: Hepatocellular carcinomas (HCCs) with metastases to the right atrium (RA) and lungs are rare, with a poor prognosis. Furthermore, the treatment outcomes in patients with advanced HCCs remain unsatisfactory. PATIENT CONCERNS: A 46-year-old man presented to our hospital for dyspnea on exertion and abdominal pain. DIAGNOSES: HCC and extra-hepatic metastases to the lung and RA. INTERVENTIONS: Multidisciplinary treatment including radiotherapy (RT), transarterial chemoembolization (TACE), and sorafenib...
October 2018: Medicine (Baltimore)
Ahmed Abbas, Yusuf A Rajabally
Intravenous immunoglobulin (IVIg) forms a cornerstone of effective treatment for acute and chronic inflammatory neuropathies, with a class I evidence base in Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). It is generally considered to be a safe therapy however there are several recognised complications which are reviewed in this article. Most adverse events are immediate and mild such as headache, fever and nausea although more serious immediate reactions such as anaphylaxis may rarely occur...
October 17, 2018: Current Drug Safety
Young Hwan Park, Hyun Woo Kim, Hyuk Soon Kim, Seung Taek Nam, Dajeong Lee, Min Bum Lee, Keun Young Min, Jimo Koo, Su Jeong Kim, Young Mi Kim, Hyung Sik Kim, Wahn Soo Choi
Mast cells are the most prominent effector cells of Type 1 hypersensitivity immune responses. CYC116 [4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl] pyrimidin-2-amine] is under development to be used as an anti-cancer drug, but the inhibitory effects of CYC116 on the activation of mast cells and related allergy diseases have not reported as of yet. In this study, we demonstrated, for the first time, that CYC116 inhibited the degranulation of mast cells by antigen stimulation (IC50 , ~1.42 μM)...
October 11, 2018: Biomolecules & Therapeutics
Ousama Rachid, Keith J Simons, Mutasem Rawas-Qalaji
In community settings, IM injection of 0.3 mg epinephrine (Epi) using an auto-injector is the drug of choice for treatment of anaphylaxis. Previously, a taste-masking (TM) formulation of fast-disintegrating sublingual tablets (FDSTs) was developed in our lab. Also, Epi was micronized (Epi-MC) successfully and reduced the previously achieved bioequivalent sublingual Epi dose to 0.3 mg IM injection by half using non-taste-masked fast-disintegrating sublingual tablets (TM-FDSTs). Our objective for this study was to evaluate the sublingual absorption of Epi-MC using TM-FDST...
October 15, 2018: AAPS PharmSciTech
Ajay Gupta, Raymond Pratt, Bhoopesh Mishra
Iron deficiency is a significant health problem across the world. While many patients benefit from oral iron supplements, some, including those on hemodialysis require intravenous iron therapy to maintain adequate iron levels. Until recently, all iron compounds suitable for parenteral administration were colloidal iron-carbohydrate conjugates that require uptake and processing by macrophages. These compounds are associated with variable risk of anaphylaxis, oxidative stress, and inflammation, depending on their physicochemical characteristics...
October 15, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Przemyslaw Zdziarski, Andrzej Gamian, Jacek Majda, Agnieszka Korzeniowska-Kowal
[This corrects the article DOI: 10.1186/s13223-017-0213-x.].
2018: Allergy, Asthma, and Clinical Immunology
Wai Sze Tong, Agatha Wt Yuen, Christine Yy Wai, Nicki Yh Leung, Ka Hou Chu, Patrick Sc Leung
Seafood allergy is a hypersensitive disorder with increasing prevalence worldwide. Effective and accurate diagnostic workup for seafood allergy is essential for clinicians and patients. Parvalbumin and tropomyosin are the most common fish and shellfish allergens, respectively. The diagnosis of seafood allergies is complicated by cross-reactivity among fish allergens and between shellfish allergens and other arthropods. Current clinical diagnosis of seafood allergy is a complex algorithm that includes clinical assessment, skin prick test, specific IgE measurement, and oral food challenges...
2018: Journal of Asthma and Allergy
Rudolph M Navari, Lee S Schwartzberg
To examine pharmacologic and clinical characteristics of neurokinin 1 (NK1 )-receptor antagonists (RAs) for preventing chemotherapy-induced nausea and vomiting (CINV) following highly or moderately emetogenic chemotherapy, a literature search was performed for clinical studies in patients at risk of CINV with any approved NK1 RAs in the title or abstract: aprepitant (capsules or oral suspension), HTX019 (intravenous [IV] aprepitant), fosaprepitant (IV aprepitant prodrug), rolapitant (tablets or IV), and fixed-dose tablets combining netupitant or fosnetupi-tant (IV netupitant prodrug) with the 5-hydroxytryptamine type 3 (5HT3 ) RA palonosetron (oral or IV)...
2018: OncoTargets and Therapy
Brandi T Johnson-Weaver, Herman F Staats, A Wesley Burks, Michael D Kulis
Food allergies are a growing public health concern with an estimated 8% of US children affected. Peanut allergies are also on the rise and often do not spontaneously resolve, leaving individuals at-risk for potentially life-threatening anaphylaxis throughout their lifetime. Currently, two forms of peanut immunotherapy, oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT), are in Phase III clinical trials and have shown promise to induce desensitization in many subjects. However, there are several limitations with OIT and EPIT, such as allergic side effects, daily dosing requirements, and the infrequent outcome of long-term tolerance...
2018: Frontiers in Immunology
Meng Fu, Shuilian Fu, Saihong Ni, Danni Wang, Tie Hong
Most allergic reactions are induced by mast cell activation. Mast cells play vital roles in the pathogenesis of allergic diseases. Bisdemethoxycurcumin (BDMC), a natural curcuminoid, has potential anti-allergic effects. Hence, we explored the effect of BDMC on mast cell-mediated allergic diseases. The study proved that BDMC suppresses β-hexosaminidase release, granule release, and membrane ruffling in monoclonal anti-2,4,6-dinitrophenyl-immunoglobulin (Ig) E/human serum albumin (DNP-IgE/HSA)-stimulated rat basophilic leukaemia cells (RBL-2H3 cells), and BDMC suppressed ovalbumin (OVA)-induced allergic rhinitis (AR) symptoms and OVA-specific IgE levels in AR mice...
October 10, 2018: International Immunopharmacology
Abida Zahirović, Ana Koren, Peter Kopač, Borut Štrukelj, Peter Korošec, Mojca Lunder
Identification of Api m 1 IgE epitopes and characterization of their mimotopes described herein represents an important step towards better understanding of sting anaphylaxis pathogenesis and towards development of alternative immunotherapy for bee venom allergy.
October 10, 2018: Journal of Allergy and Clinical Immunology
Tomonori Hirashima, Yoshitaka Tamura, Yuki Han, Shoji Hashimoto, Ayako Tanaka, Takayuki Shiroyama, Naoko Morishita, Hidekazu Suzuki, Norio Okamoto, Shinobu Akada, Makoto Fujishima, Yoshihisa Kadota, Kazuya Sakata, Akiko Nishitani, Satoru Miyazaki, Takayuki Nagai
BACKGROUND: In our previous study, colorectal cancer (CRC) patients with active Mycobacterium tuberculosis (MTB) tolerated concurrent anti-cancer chemotherapy (anti-CCT) and anti-MTB chemotherapy. In this study, we retrospectively confirmed the efficacy and safety of concurrent chemotherapy in a greater number of patients with different types of malignancies. METHODS: We enrolled 30 patients who were treated concurrently with anti-CCT and anti-MTB regimens between January 2006 and February 2016...
October 12, 2018: BMC Cancer
Heinrich C Weber, Eugene Haydn Walters, Mai Frandsen, Shyamali C Dharmage
OBJECTIVE: Asthma and allergic diseases are poorly described in rural areas. The objective of this study was, therefore, to determine the prevalence of wheezing, asthma, and other allergic disorders among children living in regional and rural Tasmania. METHODOLOGY: Data from a cross-sectional survey using standardized questionnaires of asthma, allergic conditions and food allergies were collected from 39 primary schools across North West Tasmania. We enrolled 1075 children between 6 and 8 years...
October 12, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Axel Trautmann, Johanna Stoevesandt
BACKGROUND: Anaphylaxis-like reactions developing within a few minutes are the most frequent complications of subcutaneous or submucosal injections of local anaesthetics (LAs), and topically applied LAs are potential contact allergens. In addition, injected LAs have been reported to induce delayed reactions, including local inflammation at the injection site, and various general symptoms. OBJECTIVES: To assess the frequency and symptoms of late-type hypersensitivity occurring several hours after LA injections...
October 11, 2018: Contact Dermatitis
Chinese Society Of Toxicology Poisoning And Treatment Of Specialized Committee, Hubei Emergency Medicine Committee Of Chinese Medical Association, Hubei Provincial Poisoning And Occupational Disease Union, Xianyi Yang, Min Xiao
To improve the diagnosis and treatment of wasp sting, summarize the experience, the experts from Chinese Society of Toxicology Poisoning and Treatment of Specialized Committee, Hubei Emergency Medicine Committee of Chinese Medical Association and Hubei Provincial Poisoning and Occupational Disease Union made the Expert consensus statement on standardized diagnosis and treatment of wasp stings in China on the development of domestic and oversea in this field. The consensus statement emphasized the idea of staged treatment, different treatments at different stages, and strived to achieve bundling and individuation...
September 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
J Martí Garrido, R López Salgueiro, B Bartolomé Zavala, C Perales Chordá, D Hernández Fernández de Rojas
No abstract text is available yet for this article.
October 8, 2018: Annals of Allergy, Asthma & Immunology
Mi Ae Kim, Dong Kyu Kim, Hyeon Jong Yang, Young Yoo, Youngmin Ahn, Hae Sim Park, Hyun Jong Lee, Yi Yeong Jeong, Bong Seong Kim, Woo Yong Bae, An Soo Jang, Yang Park, Young Il Koh, Jaechun Lee, Dae Hyun Lim, Jeong Hee Kim, Sang Min Lee, Yong Min Kim, Young Joon Jun, Hyo Yeol Kim, Yunsun Kim, Jeong Hee Choi
PURPOSE: Pollen-food allergy syndrome (PFAS) is an immunoglobulin E (IgE)-mediated allergy in pollinosis patients caused by raw fruits and vegetables and is the most common food allergy in adults. However, there has been no nationwide study on PFAS in Korea. In this study, we investigated the prevalence and clinical characteristics of PFAS in Korea. METHODS: Twenty-two investigators participated in this study, in which patients with allergic rhinoconjunctivitis and/or bronchial asthma with pollen allergy were enrolled...
November 2018: Allergy, Asthma & Immunology Research
Kavya Venkatesh, James Yun, Sophie Bakis-Petsoglou
No abstract text is available yet for this article.
October 2018: JAAD Case Reports
Nicholas G Kounis, Gianfranco Cervellin, Ioanna Koniari, Laura Bonfanti, Periklis Dousdampanis, Nikolaos Charokopos, Stelios F Assimakopoulos, Stavros K Kakkos, Ioannis G Ntouvas, George D Soufras, Ioannis Tsolakis
The first reported human anaphylactic death is considered to be the Pharaoh Menes death, caused by a wasp sting. Currently, anaphylactic cardiovascular events represent one of most frequent medical emergencies. Rapid diagnosis, prompt and appropriate treatment can be life saving. The main concept beyond anaphylaxis lies to myocardial damage and ventricular dysfunction, thus resulting in cardiovascular collapse. Cardiac output depression due to coronary hypoperfusion from systemic vasodilation, leakage of plasma and volume loss due to increased vascular permeability, as well as reduced venous return, are regarded as the main causes of cardiovascular collapse...
September 2018: Annals of Translational Medicine
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