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https://www.readbyqxmd.com/read/30118245/clinical-characteristics-of-exogenous-progestogen-hypersensitivity
#1
Eun-Jung Jo, Seung-Eun Lee, Hye-Kyung Park
BACKGROUND: Autoimmune progesterone dermatitis is a rare disease characterized by eruption recurrence in the luteal phase of each menstrual cycle. As synthetic progesterones are increasingly used for assisted reproductive techniques (ARTs) for infertility or prevention of abortion, cases of dermatitis caused by exogenous progesterone have been reported. OBJECTIVE: To investigate the clinical characteristics of exogenous progestogen hypersensitivity (PH). METHODS: We retrospectively reviewed data from patients presenting with dermatitis induced by exogenous progesterone between 2011 and 2016...
August 13, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/30113437/nationwide-survey-of-hospitalization-due-to-pediatric-food-induced-anaphylaxis-in-the-united-states
#2
Yusuke Okubo, Kotaro Nochioka, Marcia A Testa
OBJECTIVE: Anaphylaxis is a common, serious, systemic allergic reaction. In the United States, the change of annual hospitalization rates by anaphylaxis-trigger foods and risk factors associated with severity remain unclear. METHODS: Hospital discharge records of food-induced anaphylactic reactions of individuals younger than 20 years were obtained from Kids' Inpatient Database in 2006, 2009, and 2012 and were weighted to estimate the number of hospitalizations in the United States...
August 14, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/30107868/subcutaneous-c1-esterase-inhibitor-to-prevent-hereditary-angioedema-attacks-safety-findings-from-the-compact-trial
#3
H Henry Li, Sarah Mycroft, Sandra Christiansen, Daniel N Wood, Henrike Feuersenger, Dipti Pawaskar, Iris Jacobs
BACKGROUND: The first subcutaneous (SC) C1-esterase inhibitor concentrate (C1-INH) was approved by the U.S. Food and Drug Administration in June 2017 as routine prophylaxis to prevent hereditary angioedema attacks in adolescents and adults at a dose of 60 IU/kg twice weekly based on the phase III Clinical Study for Optimal Management of Preventing Angioedema With Low-volume Subcutaneous C1-Inhibitor Replacement Therapy (COMPACT) trial. OBJECTIVE: This article aimed to evaluate the relationship of the C1-INH (SC) dose regimens tested in the COMPACT trial (40 IU/kg and 60 IU/kg twice weekly) and the occurrence of adverse events (AEs)...
August 14, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/30105458/a-new-non-dilution-rapid-desensitization-protocol-successfully-applied-to-all-grade-platinum-hypersensitivity
#4
Soo Jie Chung, Sung-Yoon Kang, Rae-Young Kang, Young-Chan Kim, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, Hye-Ryun Kang
PURPOSE: Desensitization is a safe alternative for patients with hypersensitivity reactions (HSRs) to platinum-based chemotherapeutic agents and widely used in real practice by employing stepwise administration of multiple serial dilutions of the culprit drugs. However, its labor-intensive nature has required a simpler protocol that is easier to prepare and perform. METHODS: We performed an observational study of patients with platinum HSR who underwent a new non-dilution one-bag desensitization protocol...
August 13, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/30104977/spinacetin-suppresses-the-mast-cell-activation-and-passive-cutaneous-anaphylaxis-in-mouse-model
#5
Ning Ji, Shunli Pan, Chen Shao, Yufen Chen, Zhe Zhang, Ran Wang, Yuling Qiu, Meihua Jin, Dexin Kong
We previously reported the anti-inflammatory and anti-asthmatic activities of the extract of the Inula japonica Thunb. Aiming for discovery of a novel anti-inflammatory compound, we isolated spinacetin from the extract and investigated its in vitro and in vivo anti-inflammatory effect and the related mechanism. Effect of spinacetin on the Syk signaling pathway was studied in bone marrow-derived mast cells (BMMCs), and that on the nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs) was investigated in Rat basophilic leukemia (RBL)-2H3 cells and human mast cell line (HMC-1)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30102015/spontaneous-hemoperitoneum-and-anaphylactic-shock-associated-with-hymenoptera-envenomation-in-a-dog
#6
Dana J Caldwell, Kaelyn E Petras, Brandi L Mattison, Raegan J Wells, Victoria L Heffelman
OBJECTIVE: To describe the clinical presentation of a dog with spontaneous hemoperitoneum associated with anaphylactic shock from Hymenoptera envenomation. CASE SUMMARY: An 8-year-old female neutered Beagle presented as an emergency for acute onset of collapse, hematemesis, and hematochezia. The dog was tachycardic, tachypneic, and hypotensive. Initial assessment revealed a hemoperitoneum with documentation of a nonclotting sanguineous peritoneal effusion with PCV 81% and total protein concentration 65 g/L (6...
August 13, 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/30102006/dietary-supplementation-with-non-digestible-oligosaccharides-reduces-allergic-symptoms-and-supports-low-dose-oral-immunotherapy-in-a-peanut-allergy-mouse-model
#7
Laura Wagenaar, Marianne Bol-Schoenmakers, Giulio Giustarini, Marlotte M Vonk, Betty C A M van Esch, Leon M J Knippels, Johan Garssen, Joost J Smit, Raymond H H Pieters
SCOPE: A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side-effects. Non-digestible short- and long-chain fructo-oligosaccharides (scFOS/lcFOS), reduced allergy development in murine models. We therefor hypothesized that scFOS/lcFOS can also support the efficacy of OIT in a peanut allergy model. METHODS AND RESULTS: After sensitization to peanut extract (PE) using cholera toxin, C3H/HeOuJ mice were fed a 1% scFOS/lcFOS or control diet and received OIT (1...
August 13, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/30100659/well-tolerated-oral-cyclosporine-in-a-case-of-hypersensitivity-to-parenteral-cyclosporine-in-postallogeneic-bone-marrow-transplantation
#8
Mahsa Moeinian, Hamed Sotoude, Zahra Mohebbi, Ali Asadollahi-Amin, Rambod Mozafari
Cyclosporine is one of the main drugs used for the prophylaxis of graft versus host disease in bone marrow transplanted patients. Hypersensitivity reaction to intravenous cyclosporine is rare and might be due to its vehicle polyoxyethylated castor oil, Cremophor EL. The exact mechanism is unknown, but IgE and IgG antibodies, complement, and histamine release have been considered to play a role in the development of this reaction. Here, we describe a case of anaphylaxis to intravenous cyclosporine, which was developed in a 19-year-old Iranian female with acute myeloid leukemia who underwent allogeneic bone marrow transplantation from her sister...
March 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30100485/novel-low-abundance-allergens-from-mango-via-combinatorial-peptide-libraries-treatment-a-proteomics-study
#9
Erik Elvin Gomez Cardona, Karen Heathcote, Luis M Teran, Pier Giorgio Righetti, Egisto Boschetti, Alfonsina D'Amato
Mango allergy is a rare condition, which may cause severe hypersensitivity reactions, such as anaphylaxis, angioedema, asthma and contact dermatitis. By exploiting the combinatorial peptide ligand library (CPLL) technology, mango proteomes have been extracted and the presence of traces of allergens assessed via Western blot analysis two-dimensional maps. Upon reactive spot elution and mass spectrometry analyses, four major mango allergens could be identified for the first time and shown to be in common with three of the five known banana species...
December 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/30099779/the-role-of-environmental-factors-in-allergy-a-critical-reappraisal
#10
REVIEW
Stefanie Gilles, Cezmi Akdis, Roger Lauener, Peter Schmid-Grendelmeier, Thomas Bieber, Georg Schäppi, Claudia Traidl-Hoffmann
Allergies are usually referred to as type I hypersensitivity reactions against innocuous environmental antigens, characterized by a Th2/IgE-dominated inflammation. They can manifest themselves in various organs, such as skin, gastro-intestinal and respiratory tract, and comprise diseases as diverse as allergic rhinitis and conjunctivitis, bronchial asthma, oral allergy syndrome, food allergy, urticaria and atopic eczema, but also anaphylactic shock. Within the last decades there was a significant global increase in allergy prevalence, which has been mostly attributed to changes in environment and life style...
August 12, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/30097369/design-synthesis-and-activity-evaluation-of-novel-erythropoietin-mimetic-peptides
#11
Siliang Feng, Shaohua Chang, Lingdi Yan, Huajin Dong, Xiaoyu Xu, Chenhong Wang, Yuanjun Liang, Keliang Liu
The approval of the erythropoietin (EPO) mimetic peptide drug peginesatide in 2012 was a breakthrough for the treatment of secondary anemia. However, due to severe allergic reactions, peginesatide was recalled a year later. In this study, 12 novel peptides were designed and synthesized by substituting specific amino acids of the monomeric peptide in peginesatide, with the aim of obtaining new EPO mimetic peptides with higher activities and lower side effects than the parent compound. Their cell proliferation activities were evaluated, and the structure-activity relationships were analyzed...
August 3, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/30096611/population-histamine-burden-assessed-using-wastewater-based-epidemiology-the-association-of-1-4%C3%A2-methylimidazole-acetic-acid-and-fexofenadine
#12
Phil M Choi, Jake W O'Brien, Jiaying Li, Guangming Jiang, Kevin V Thomas, Jochen F Mueller
Systematic sampling and analysis of wastewater has become an important tool for monitoring consumption of drugs and other substances, and has been proposed as a method to evaluate aspects of population health using endogenous biomarkers. 1,4‑methylimidazoleacetic acid (MIAA) is an endogenous biomarker and metabolite of histamine turnover. Its urinary excretion is elevated in conditions such as mastocytosis, hay fever, hives, food allergies and anaphylaxis. The aim of this study was to develop and apply methods for MIAA in wastewater and compare its occurrence with antihistamine use in wastewater...
August 7, 2018: Environment International
https://www.readbyqxmd.com/read/30096600/allergenicity-assessment-of-buchanania-lanzan-protein-extract-in-balb-c-mice
#13
Sachin Kumar, Akanksha Sharma, Rinkesh Kumar Gupta, Ajay Kumar Verma, Premendra D Dwivedi
Tree nuts are among "Big Eight" and have been reported globally for causing allergy. Buchanania lanzan (Bl) is one of the major tree nuts consumed by Indian population. However, very little is known about B. lanzan's induced allergic manifestation. Therefore, evaluation of it's allergenic potential was undertaken. Bl-crude protein extract sensitized BALB/c mice sera were used to identify the allergic proteins by it's IgE binding capability. The major IgE binding proteins found with molecular weight of 11, 20, 23, 25, 48, 54, and 65 kDa...
August 7, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30095397/pitfalls-in-anaphylaxis-diagnosis-and-management-at-a-university-emergency-department
#14
Amy Castilano, Britni Sternard, Earl D Cummings, Runhua Shi, Thomas Arnold, Sami L Bahna
BACKGROUND: Some previous reports revealed suboptimal management of anaphylaxis (ANX) in the emergency department (ED). OBJECTIVE: To evaluate the recorded diagnosis and management of patients who presented with ANX at our university hospital ED and to assess how the management correlated with the severity of the case and the training level of the ED staff. METHODS: A descriptive study that involved reviewing the electronic medical records of patients who presented with ANX at the ED during a period of 4 years...
July 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/30093714/polymorphisms-in-cep68-gene-associated-with-risk-of-immediate-selective-reactions-to-non-steroidal-anti-inflammatory-drugs
#15
James R Perkins, Marialbert Acosta-Herrera, María C Plaza-Serón, Raquel Jurado-Escobar, Inmaculada Doña, Elena García-Martín, María Isidoro-García, Joan Bartra, David Ribas-Perez, Cristobalina Mayorga, María J Torres, Carlos Flores, José A Cornejo-García
Non-steroidal anti-inflammatory drugs (NSAIDs) are the main triggers of drug hypersensitivity reactions. Such reactions can be pharmacologically or immunologically mediated, but in both cases individual susceptibility can be influenced by genetic factors. Polymorphisms in centrosomal protein of 68 kDa (CEP68) have been associated with pharmacologically mediated NSAIDs reactions. Here, we evaluated this gene in immunologically mediated single-NSAID-induced urticaria/angioedema or anaphylaxis (SNIUAA) by analyzing 52 single nucleotide polymorphisms in CEP68 in 176 patients and 363 NSAIDs-tolerant controls...
August 10, 2018: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/30093499/beer-anaphylaxis-due-to-coriander-as-hidden-allergen
#16
Luisa Brussino, Stefania Nicola, Veronica Giorgis, Giovanni Rolla
Beer is one of the most widely consumed alcoholic beverage all over the world. Although the production and consumption of this beverage is diffuse, allergic reactions are very uncommonly reported, mainly due to wheat, yeast or hops allergy. More recently, many foods and drinks have been flavoured with spices, with a reported increase in allergic reactions. We report on a case of a young woman who experienced anaphylaxis due to coriander-flavoured beer. This is the first case of beer anaphylaxis due to coriander, which had been added to the beer as aromatising substance...
August 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30093380/prevalence-of-anaphylaxis-among-adults-admitted-to-critical-care-for-severe-asthma-exacerbation
#17
Ayobami T Akenroye, Abayomi Ajala, Elham Azimi-Nekoo, Gabriele S de Vos
BACKGROUND: In asthmatics, making a diagnosis of anaphylaxis could be challenging as respiratory symptoms are a common feature of both conditions. Identifying anaphylaxis is important to providing appropriate care. A prior study showed that anaphylaxis is sometimes misdiagnosed as acute asthma in children. We sought to identify the percentage of adults admitted to the intensive care unit (ICU) with asthma exacerbations who met criteria for anaphylaxis. METHODS: Retrospective chart review of adults admitted with acute asthma to the ICU at Jacobi Medical Center, a Level 1 trauma centre in Bronx, New York...
August 9, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/30090322/survey-of-practitioners-handling-slow-lorises-primates-nycticebus-an-assessment-of-the-harmful-effects-of-slow-loris-bites
#18
Matthew Gardiner, Ariana Weldon, Stephanie A Poindexter, Nancy Gibson, K Anna I Nekaris
Slow lorises ( Nycticebus spp. ) are one of six venomous mammals, and the only known venomous primate. In the wild envenomation occurs mainly during conspecific competition for mates and territory, but may also be used as an application against parasites or for predator defense. Envenomation in humans is documented, with the most extreme accounts detailing near-fatal anaphylactic shock. From September 2016 - August 2017, we received questionnaire responses from 80 wild animal practitioners working with Nycticebus spp ...
2018: Journal of Venom Research
https://www.readbyqxmd.com/read/30083558/intramuscular-epinephrine-induced-transient-st-elevation-myocardial-infarction
#19
Binav Shrestha, Paritosh Kafle, Shivani Thapa, Suyash Dahal, Vijay Gayam, Alix Dufresne
Introduction. Myocardial infarction in the setting of anaphylaxis may result from the anaphylaxis itself or from the epinephrine used to treat the anaphylaxis. While cases of myocardial infarction due to large doses of intravenous epinephrine have previously been reported, myocardial infarction after therapeutic doses of intramuscular epinephrine is rarely reported. Case Report. A 23-year-old male presented with sudden onset of difficulty in swallowing and speech after eating takeout food. He was treated with intramuscular epinephrine for presumed angioedema following which he immediately developed chest tightness associated with ST elevation on electrocardiogram and elevated serum troponin...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/30083085/inhibitory-effects-of-quail-egg-on-mast-cells-degranulation-by-suppressing-par2-mediated-mapk-and-nf-kb-activation
#20
Priscilia Lianto, Fredrick O Ogutu, Yani Zhang, Feng He, Huilian Che
Background: Quail egg (QE) has been reported to possess an anti-allergic and anti-inflammatory activity. We have demonstrated that whole QE was able to attenuate the allergic symptoms in food allergy-induced EoE murine model, but whether QE albumen or QE yolk plays a more important role still remains unclear. Objective: In this current study, we investigated the suppressive role of QE in mast cell degranulation and cytokine production of the effect phase response...
2018: Food & Nutrition Research
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