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https://www.readbyqxmd.com/read/30557718/the-journal-of-allergy-and-clinical-immunology-in-practice-2018-highlights
#1
REVIEW
Michael Schatz, Scott H Sicherer, David Khan, Robert S Zeiger
A large number of clinically impactful studies and reviews were published in this Journal in 2018. This article provides highlights of the original research published in 2018 issues of JACI: In Practice on the subjects of anaphylaxis, asthma, dermatitis, drug allergy, eosinophilic disorders, food allergy, immune deficiency, rhinitis/upper respiratory disease, and urticaria/angioedema. Within each topic, practical aspects of diagnosis and management are emphasized. Treatments discussed include lifestyle modifications, allergen avoidance therapy, positive and negative effects of pharmacologic therapy, and various forms of immunologic and desensitization management...
December 14, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/30557713/immediate-hypersensitivity-to-polyethylene-glycols-and-polysorbates-more-common-than-we-have-recognized
#2
Cosby A Stone, Yiwei Liu, Mary V Relling, Matthew S Krantz, Amanda L Pratt, Andrew Abreo, Jonathan A Hemler, Elizabeth J Phillips
BACKGROUND: The most common immediate hypersensitivity to macrogols is associated with PEG 3350, however the epidemiology, mechanisms and cross-reactivity are poorly understood. Thousands of medications contain either PEGs or structurally similar polysorbates. OBJECTIVE: Our objective was to better understand the mechanism, cross-reactivity and scope of PEG hypersensitivity. METHODS: Two cases with a past history of immediate hypersensitivity to PEG-containing medications were used to study potential mechanisms and cross-reactivity of immediate reactions to PEG 3350...
December 14, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/30556363/allergy-inhibitory-receptor-1-inhibits-autoantibody-production-via-upregulation-of-apoptotic-debris-clearance-by-macrophages
#3
Akira Iizuka, Seiji Segawa, Yuya Kondo, Shunta Kaneko, Masahiro Yokosawa, Kotona Furuyama, Haruka Miki, Satoko Tahara-Hanaoka, Akira Shibuya, Hiroto Tsuboi, Daisuke Goto, Isao Matsumoto, Shiro Shibayama, Takayuki Sumida
AIM: Allergy inhibitory receptor-1 (Allergin-1) is a newly identified immune regulatory molecule thought to influence autoantibody production. Autoantibody production, like that observed in Allergin-1-deficient mice, is crucial in the pathogenesis of several autoimmune diseases such as systemic lupus erythematosus. The purpose of this study is to clarify the regulatory role of Allergin-1-mediated autoantibody production using a murine model of thymocytic anaphylaxis. METHODS: C57BL/6 (WT) and Allergin-1-deficient mice were treated with apoptotic cells from naive thymocytes stimulated by dexamethasone...
December 16, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30553053/fruit-for-thought-anaphylaxis-to-fruit-pectin-in-foods
#4
Peter Capucilli, Katie Kennedy, Ashley M Kazatsky, Antonella Cianferoni, Jonathan M Spergel
Pectin is a structural heteropolysaccharide previously associated with occupational asthma and only rare accounts of allergy. Few case reports, however, suggest that pectin may contribute to atypical or idiopathic food reactions, particularly in patients with IgE-mediated allergy to tree nuts.
December 12, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/30551404/reevaluation-of-the-post-marketing-safety-of-xuebijing-injection-based-on-real-world-and-evidence-based-evaluations
#5
Can Wang, Qing-Ping Shi, Feng Ding, Xiao-Dong Jiang, Wei Tang, Mei-Ling Yu, Jin-Quan Cheng
AIMS: To determine the causes of adverse reactions associated with Xuebijing injection and provide medical evidence for its safe and rational post-marketing use in clinical practice. MATERIALS AND METHODS: We used prospective nested case-control and prescription sequence analysis designs. Using data from the Hospital Information System, patients exhibiting trigger signals after receiving Xuebijing injection were classified as suspected allergic patients. Logistic regression analysis was performed on the risk factors associated with Xuebijing-induced allergic reactions...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30544846/glucocorticoid-receptor-binding-inhibits-an-intronic-il33-enhancer-and-is-disrupted-by-rs4742170-t-allele-associated-with-specific-wheezing-phenotype-in-early-childhood
#6
Alisa M Gorbacheva, Dmitry V Kuprash, Nikita A Mitkin
Interleukin 33 (IL-33) is a cytokine constitutively expressed by various cells of barrier tissues that contribute to the development of inflammatory immune responses. According to its function as an alarmin secreted by lung and airway epithelium, IL-33 plays a significant role in pathogenesis of allergic disorders. IL-33 is strongly involved in the pathogenesis of asthma, anaphylaxis, allergy and dermatitis, and genetic variations in IL33 locus are associated with increased susceptibility to asthma. Genome-wide association studies have identified risk "T" allele of the single-nucleotide polymorphism rs4742170 located in putative IL33 enhancer area as susceptible variant for development of specific wheezing phenotype in early childhood...
December 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30544107/characterization-of-patients-with-ibuprofen-hypersensitivity
#7
Erika Yue Lee, Daniel Teitelbaum, Marcus Chiam, Peter Vadas
BACKGROUND: Ibuprofen is the most frequently used over-the-counter nonsteroidal anti-inflammatory drug (NSAID) in North America. While it has been commonly implicated in drug-induced hypersensitivity reactions, there is limited literature specifically on ibuprofen hypersensitivity. OBJECTIVES: To characterize the demographics and clinical course of hypersensitivity reactions in a cohort of patients with ibuprofen allergy. METHODS: A retrospective chart review of patients diagnosed with ibuprofen allergy was conducted between 2008 and 2016 in an allergy clinic at a tertiary care academic institution...
December 13, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30541918/the-incidence-and-nature-of-allergic-and-anaphylactic-reactions-during-pediatric-procedural-sedation-a-report-from-the-pediatric-sedation-research-consortium
#8
James H Hertzog, Krista Preisberga, Scott Penfil
BACKGROUND AND OBJECTIVES: Anaphylaxis is rare but life-threatening. Its incidence during pediatric procedural sedation outside of the operating room is unknown. We used data from the Pediatric Sedation Research Consortium (PSRC) to determine the incidence and nature of allergic and anaphylactic reactions in this practice. METHODS: A retrospective observational study of prospectively collected information in the PSRC's multicenter database was performed. Cases of allergic reaction were identified...
December 12, 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/30541650/-epinephrine-combined-with-acupuncture-therapy-can-treat-anaphylactic-shock-mice-through-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway-a-rat-experimental-result
#9
Jie Zhang, Caibin Gan
OBJECTIVE: To explore the therapeutic effect of epinephrine combined with acupuncture on anaphylactic shock and its mechanism. METHODS: Sixty male Kunming mice were randomly divided into normal saline (NS) group, anaphylactic shock model group, and integrated traditional Chinese and Western medicine treatment group with 20 mice in each group. The anaphylactic shock model was reproduced by egg albumin infusion: intraperitoneal injection of 0.25 mL egg albumin (0...
November 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/30541628/identification-and-characterization-of-the-causative-triatomine-bugs-of-anaphylactic-shock-in-zhanjiang-china
#10
Ya-Lan Huang, Da-Na Huang, Wei-Hua Wu, Fan Yang, Xiao-Min Zhang, Miao Wang, Yi-Jun Tang, Qian Zhang, Li-Fei Peng, Ren-Li Zhang
BACKGROUND: Two health concerns primarily related to triatomine bugs are transmission of Trypanosoma cruzi through infective feces, and allergic reactions induced by triatomine bites. In the Southwestern United States, reduviid bugs bites commonly cause insect allergy. In South China, four cases of anaphylactic shock have been reported after this bite exposure. To further classify the species of these bugs and confirm the sensitization of the triatomine saliva, we caught triatomine bugs from the region where the bites occurred and performed phylogenetic and immunohistochemical (IHC) analysis...
December 11, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/30540798/lower-allergen-levels-in-hypoallergenic-curly-horses-a-comparison-among-breeds-by-measurements-of-horse-allergens-in-hair-and-air-samples
#11
Eva Zahradnik, Bente Janssen-Weets, Ingrid Sander, Benjamin Kendzia, Wolfgang Mitlehner, Caroline May, Monika Raulf
BACKGROUND: Exposure to horses can cause severe allergic reactions in sensitized individuals. The breed, American Bashkir Curly Horse is categorized as hypoallergenic, primarily due to reports of allergic patients experiencing fewer symptoms while handling this special breed. The possible reasons for this phenomenon could be lower allergen production and/or reduced allergen release into the air because of increased sebum content in their skin and hair compared to other breeds. Therefore, the aim of the current study was to compare different horse breeds in relation to allergen content in hair and airborne dust samples...
2018: PloS One
https://www.readbyqxmd.com/read/30537763/adherence-to-subcutaneous-allergen-immunotherapy-in-southeast-turkey-a-real-life-study
#12
Tugba S Tat
BACKGROUND Subcutaneous immunotherapy (SCIT) in allergic rhinitis (AR) and asthma is a very effective treatment, but adherence is still a serious problem. Studies addressing real-life adherence to SCIT are rare in the literature. The aim of this study was to evaluate the adherence to SCIT in AR and asthma. MATERIAL AND METHODS The medical records of patients prescribed SCIT for treatment of AR and/or asthma were evaluated. Patients who continued the SCIT treatment as prescribed were defined as adherent, patients who stopped the treatment before the recommended period were defined as nonpersistent, and those who never started the treatment were defined as primary poor adherence...
December 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30536695/systemic-mastocytosis-in-adults-2019-update-on-diagnosis-risk-stratification-and-management
#13
Animesh Pardanani
OVERVIEW: Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in extra-cutaneous organs. DIAGNOSIS: The major criterion is presence of multifocal clusters of abnormal MC in the bone marrow. Minor diagnostic criteria include elevated serum tryptase level, abnormal MC CD25 expression, and presence of KITD816V mutation. RISK STRATIFICATION: Establishing SM subtype as per the World Health Organization classification system is an important first step...
December 8, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/30535629/evaluation-of-the-reported-rates-of-severe-hypersensitivity-reactions-associated-with-ferric-carboxymaltose-and-iron-iii-isomaltoside-1000-in-europe-based-on-data-from-eudravigilance-and-vigibase%C3%A2-between-2014-and-2017
#14
Birgit Ehlken, Lennart Nathell, Annegret Gohlke, Derya Bocuk, Massoud Toussi, Stefan Wohlfeil
INTRODUCTION: Hypersensitivity reactions (HSRs) are among the known adverse events of intravenous (i.v.) iron products. Of these, particularly severe HSRs such as anaphylaxis are of great clinical concern due to their life-threatening potential. METHODS: This was a retrospective pharmacoepidemiological study with a case-population design evaluating the number of reported severe HSRs following administration of the two i.v. iron products-ferric carboxymaltose and iron (III) isomaltoside 1000-in relation to exposure in European countries from January 2014 to December 2017...
December 10, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/30531211/a-fatal-case-of-acute-renal-failure-from-envenoming-syndrome-after-massive-bee-attack-a-case-report-and-literature-review
#15
Rhome L Hughes
Envenoming syndrome is a systemic toxic reaction to the inoculation of large volume of insect venom, typically after a swarm attack from bees. Africanized honey bees are notorious for their aggressive nature, and human deaths resulting from Africanized honey bee attacks are consistently reported. Whereas anaphylaxis is the most common lethal mechanism of injury, delayed deaths can also occur as a consequence of severe venom toxicity with resultant end organ damage. Acute renal failure complicating massive envenomation is a rare but potentially fatal outcome after Africanized honey bee attack and may be heralded by laboratory evidence of rhabdomyolysis...
December 6, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/30530398/incidence-of-anaphylaxis-recorded-during-1-year-by-the-municipal-emergency-service-of-madrid-samur-pc
#16
R Gómez-Soler, M L Caballero
No abstract text is available yet for this article.
December 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30530392/severe-anaphylaxis-with-cardiac-arrest-caused-by-prick-test-with-cefuroxime
#17
R A Fernandes, F S Regateiro, J Pita, C Ribeiro, I Carrapatoso, A Todo-Bom, E Faria
No abstract text is available yet for this article.
December 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30530388/anaphylaxis-due-to-poloxamer-238
#18
A Carbonell, A I Escudero, J C Miralles, A González, C Navarro, P Cardona, L Jimeno, F Pineda
No abstract text is available yet for this article.
December 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30529549/when-is-epinephrine-prescribed-for-anaphylaxis
#19
Alberto Alvarez-Perea, Margarita Tomás-Pérez, Beatriz Ameiro, José M Zubeldia, María L Baeza
No abstract text is available yet for this article.
December 6, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/30527753/liposomes-with-cyclic-rgd-peptide-motif-triggers-acute-immune-response-in-mice
#20
Xiaoyi Wang, Huan Wang, Kuan Jiang, Yanyu Zhang, Changyou Zhan, Man Ying, Mingfei Zhang, Linwei Lu, Ruifeng Wang, Songli Wang, Diane J Burgess, Hao Wang, Weiyue Lu
Liposomes with peptides motifs have been widely applied for targeted delivery of anticancer drugs. However, few studies have questioned whether peptide modification on liposomes may induce serious toxicity associated with immune stimulation. Here, we report that display of a tumor targeting cyclic RGD peptide (e.g. c(RGDyK) and c(RGDfK) on the surface of liposomes can be a potent inducer of lethal hypersensitivity-like reactions in mice upon re-administration, with the main symptom a sudden drop in body temperature...
December 5, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
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