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"Acute Pulmoary Oedema" OR "APO" OR "Acute Pulmonary Edema" OR "APE" OR "Acute Heart Failure Syndrome" OR "AHFS"

Grégory Franck, Guillaume Even, Alexandre Gautier, Manuel Salinas, Alexia Loste, Emanuele Procopio, Anh-Thu Gaston, Marion Morvan, Sébastien Dupont, Catherine Deschildre, Sophie Berissi, Jamila Laschet, Patrick Nataf, Antonino Nicoletti, Jean-Baptiste Michel, Giuseppina Caligiuri
Aims: Inflammatory mediators, including blood cells and their products, contribute critically to atherogenesis, but the igniting triggers of inflammation remain elusive. Atherosclerosis develops at sites of flow perturbation, where the enhanced haemodynamic stress could initiate the atherogenic inflammatory process due to the occurrence of mechanic injury. We investigated the role of haemodynamic stress-induced breaches, allowing the entry of blood cells in the arterial intima, in triggering inflammation-driven atherogenesis...
December 11, 2018: European Heart Journal
Jing Ma, Dan Zhao, Xiaolin Wang, Chuanrui Ma, Ke Feng, Shuang Zhang, Yuanli Chen, Yan Zhu, Xiumei Gao, Buchang Zhao, Yong Wang, Ke Qian, Xiaoju Li, Yajun Duan, Jihong Han, Xiaoxiao Yang
Disorders of lipid metabolism and inflammation play an important role in atherosclerosis. LongShengZhi capsule (LSZ), a Chinese herbal medicine, has been used for treatment of patients with vascular diseases for many years. Herein, we determined the effect of LSZ on the progression of established atherosclerotic lesions in apoE deficient (apoE) mice. ApoE mice were pre-fed high-fat diet (HFD) for 8 weeks to induce atherosclerosis, then started with LSZ treatment contained in HFD for 10 weeks. Although LSZ had little effect on HFD-induced hypercholesterolemia, it substantially reduced en face and sinus aortic lesions...
December 10, 2018: Journal of Cardiovascular Pharmacology
Russell Jude Chander, Heidi Foo, Tingting Yong, Levinia Lim, Jayne Tan, Ming-Ching Wen, Adeline Ng, Shahul Hameed, Simon Ting, Juan Zhou, Nagaendran Kandiah
Individuals with mild cognitive impairment (MCI) exhibit varying serial position effect (SPE) performances. The relationship between SPE performance in word list recall and clinical, genetic, and neuroimaging features of MCI requires elucidation. 119 MCI and 68 cognitively normal (CN) participants underwent cognitive assessment, apolipoprotein E (ApoE) genotyping, and volumetric MRI brain scans processed via voxel-based morphometry. A 10-word recall task was used to assess SPE performance in relation to recency and primacy recall...
December 12, 2018: Aging
Liang Liu, Qinling Hu, Huihui Wu, Xiujing Wang, Chao Gao, Guoxun Chen, Ping Yao, Zhiyong Gong
Diets containing various docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) ratios protect against liver damage in mice fed with a high-fat diet (HFD). However, it is unclear whether these beneficial roles of DHA and EPA are associated with alterations of fatty acid (FA) composition in the liver. This study evaluated the positive impacts of n-6/n-3 polyunsaturated fatty acids (PUFAs) containing different DHA/EPA ratios on HFD-induced liver disease and alterations of the hepatic FA composition. ApoE-/- mice were fed with HFDs with various ratios of DHA/EPA (2 : 1, 1 : 1, and 1 : 2) and an n-6/n-3 ratio of 4 : 1 for 12 weeks...
2018: Oxidative Medicine and Cellular Longevity
Roberto Mota, Matthew J Campen, Matthew E Cuellar, William S Garver, Jacob Hesterman, Mohammed Qutaish, Tamara Daniels, Monique Nysus, Carston R Wagner, Jeffrey P Norenberg
Atherosclerosis-related morbidity and mortality remain a global concern. Atherosclerotic disease follows a slow and silent progression, and the transition from early-stage lesions to vulnerable plaques remains difficult to diagnose. Inflammation is a key component of the development of atherosclerotic plaque and consequent life-threatening complications. This study assessed 111 In-DANBIRT as an in vivo , noninvasive SPECT/CT imaging probe targeting an inflammatory marker, Lymphocyte Function Associated Antigen-1 (LFA-1), in atherosclerotic plaques...
2018: Contrast Media & Molecular Imaging
Christopher S Boot, Elizabeth Middling, Joy Allen, Robert D G Neely
BACKGROUND: Familial dysbetalipoproteinemia is associated with the accumulation of remnant lipoproteins and premature cardiovascular disease. Identification of dysbetalipoproteinemia is important because family members may be affected. Diagnostic testing involves demonstration of β-lipoprotein in the VLDL fraction or characterization of apo E3 . These investigations are complex and relatively expensive. The ratios of apo B to total cholesterol and triglycerides have been proposed as screening tests...
December 11, 2018: Clinical Chemistry
Zhiyong Huang, Guangyong Tian, Saibo Cheng, Dandan Zhao, Yu Zhang, Yuhua Jia, Fenghua Zhou
Cholesterol metabolism becomes imbalanced during the formation of macrophage-derived foam cells. Pre-B-cell colony-enhancing factor (PBEF) has recently been found to affect lipid deposition and inflammation in atherosclerosis. Here, we aimed to study the effects and molecular mechanism of Polydatin on atherosclerosis in ApoE-knockout (ApoE <mml:math xmlns:mml=""> <mml:msup> <mml:mrow/> <mml:mrow> <mml:mo>-</mml:mo> <mml:mo>∕</mml:mo> <mml:mo>-</mml:mo> </mml:mrow> </mml:msup> </mml:math> ) mice...
December 11, 2018: American Journal of Chinese Medicine
Attila Frigy, Irma Varga, Zoltán Fogarasi, Boglárka Belényi, Ildikó Kocsis
OBJECTIVE: To investigate the influence of sleep apnea on ECG and blood pressure monitoring parameters in patients with acute heart failure (AHF). METHODS: 51 hospitalized patients with AHF (13 women, 38 men, mean age 60.8 years) underwent 24-hour combined monitoring of ECG and blood pressure and sleep apnea testing before discharge. Heart rhythm (mean heart rate, arrhythmias, pauses, QT-interval, heart rate variability) and blood pressure (mean systolic and diastolic values, variability, Circadian variation) parameters were obtained for the whole day and for nighttime (22:00-06:00)...
December 11, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Zeyuan Fan, Yang Li, Hanhua Ji, Xinwen Jian
BACKGROUND/AIMS: Cardiorenal syndrome type 1(CRS1) is a serious clinical condition in patients with acute heart failure (AHF) associated with adverse clinical outcomes. Although several biomarkers for identifying CRS1 have been reported, early and accurate predicting CRS1 still remains a challenge. This study was aimed to develop and validate an individualized predictive nomogram for the risk of CRS1 in patients with AHF. METHODS: A total of 1235 AHF patients between 2013 and 2018 were included in this study...
December 7, 2018: Kidney & Blood Pressure Research
Yanqun Zhao, Qiang Meng, Yujie Lai, Li Wang, Dan Zhou, Chao Dou, Yijun Gu, Chunlai Nie, Yuquan Wei, Wei Cheng
Gram-negative bacteria defend against the toxicity of polymyxins by modifying their outer membrane lipopolysaccharide (LPS). This modification mainly occurs through the addition of cationic molecules such as phosphoethanolamine (PEA). EcEptC is a PEA transferase from Escherichia coli (E.coli). However, unlike its homologs CjEptC (Campylobacter jejuni) and MCR-1, EcEptC is unable to mediate polymyxin resistance when overexpressed in E.coli. Here, we report crystal structures of the C-terminal putative catalytic domain (EcEptCΔN, 205-577 aa) of EcEptC in apo and Zn2+ -bound states at 2...
December 7, 2018: FEBS Journal
M Kathleen Pitirri, David Begun
OBJECTIVES: Mandibular corpus robusticity (corpus breadth/corpus height) is the most commonly utilized descriptor of the mandibular corpus in the great ape and hominin fossil records. As a consequence of its contoured shape, linear metrics used to characterize mandibular robusticity are inadequate to quantify the shape of the mandibular corpus. Here, we present an alternative to the traditional assessment of mandibular shape by analyzing the outline of the mandibular corpus in cross-section using landmarks and semilandmarks...
December 7, 2018: American Journal of Physical Anthropology
I Olaposi Omotuyi, Oyekanmi Nash, David Safronetz, A Ayodeji Ojo, H Tomisin Ogunwa, S Niyi Delakun
Lassa virus infection is clinically characterized by multi-organ failure in humans. Without an FDA-approved vaccine, ribavirin is the frontline drug for treatment but with attendant toxicities. 6-fluoro-3-hydroxy-2-pyrazinecarboxamide (T-705) is an emerging alternative drug with proven anti-Lassa virus activity in experimental model. One of the mechanisms of action is its incorporation into nascent single strand RNA (ssRNA) which forms complex with Lassa nucleoprotein (LASV-NP). Here, using Molecular Dynamics simulation, the structural and electrostatics changes associated with LASV-NP- ssRNA complex has been studied when none, one or four of its bases has been substituted with T-705...
December 10, 2018: Chemical Biology & Drug Design
Hao Nie, Hong-Xia Wang, Cui Tian, Hua-Liang Ren, Fang-Da Li, Chao-Yu Wang, Hui-Hua Li, Yue-Hong Zheng
Inflammation plays a critical role in the development of abdominal aortic aneurysm (AAA). Chemokine receptor CXCR2 mediates inflammatory cell chemotaxis in several diseases. However, the role of CXCR2 in AAA and the underlying mechanisms remain unknown. In this study, we found that the CXCR2 expressions in AAA tissues from human and angiotensin II (Ang II)-infused apolipoprotein E knockout (Apo E-/- ) mice were significantly increased. The pharmacological inhibition of CXCR2 (SB265610) markedly reduced Ang II-induced AAA formation...
December 7, 2018: Heart and Vessels
Qi Chen, Jian Xiang, Ren Gong, Hai-Yang Fang, Cong-Cong Xu, Hong-Zhou Zhang, Yan-Qing Wu
One of the pathological functions of heat shock protein 22 (HSP22) is the association with inflammatory diseases and atherosclerosis. However, the effects of a high‑fat diet (HFD) or oxidized low‑density lipoprotein (ox‑LDL) combined with atorvastatin (ATV) on HSP22 expression are entirely unknown. The present study investigated the effects of ATV on HSP22 expression in HFD‑induced atherosclerotic apolipoprotein E‑deficient (ApoE‑/‑) mice and in ox‑LDL‑induced human umbilical vein endothelial cells (HUVECs)...
December 3, 2018: International Journal of Molecular Medicine
Patrícia M Oba, Pamela L Utterback, Carl M Parsons, Maria R C de Godoy, Kelly S Swanson
Chicken-based ingredients are commonly used in pet food products, but vary greatly in nutrient composition and processing conditions that may affect their protein quality and digestibility. Testing the quality of protein sources undergoing different processing conditions provides important information to pet food producers. The objective of this study was to determine the chemical composition, nutrient digestibility, protein, and amino acid (AA) digestibility scores, and nitrogen-corrected true metabolizable energy (TMEn) of chicken-based ingredients that had undergone different processing conditions (i...
December 11, 2018: Journal of Animal Science
María F Piacenza, Gladys E Calderón, Delia Enría, María C Provensal, Jaime J Polop
BACKGROUND: The Argentine Hemorrhagic Fever (AHF) is a zoonotic disease endemic in a wide area of the humid pampa of Argentina. The etiologic agent is the Junin virus that is maintained in the wild by the rodent Calomys musculinus and transmitted to humans, mainly, through aerosols generated from secretions and excretions. AIMS: To characterize and compare the assemblages of small rodent composition and diversity inside the epidemic, historic and non-endemic zone of AHF and to register C...
August 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Yibing Zhang, Xiaoyan Ma, Xiangjun Li, Tong Zhang, Meng Qin, Liqun Ren
Objective. Icariin plays a pivotal role in ameliorating atherosclerosis for animal models although its comprehensive biological role remains largely unexplored. This study aimed to fully understand the effects of icariin on atherosclerosis in high-fat diet-induced ApoE-/- mice and investigate mRNA-miRNA regulation based on microarray and bioinformatics analysis. Methods. The areas of atherosclerotic lesions in en face aorta were evaluated. Microarray analysis was performed on atherosclerotic aortic tissues...
2018: BioMed Research International
Raelene J Pickering, Christos Tikellis, Carlos J Rosado, Despina Tsorotes, Alexandra Dimitropoulos, Monique Smith, Olivier Huet, Ruth M Seeber, Rekhati Abhayawardana, Elizabeth Km Johnstone, Jonathan Golledge, Yutang Wang, Karin A Jandeleit-Dahm, Mark E Cooper, Kevin Dg Pfleger, Merlin C Thomas
Activation of the type 1 angiotensin II receptor (AT1) triggers proinflammatory signaling through pathways independent of classical Gq signaling that regulate vascular homeostasis. Here, we report that the AT1 receptor preformed a heteromeric complex with the receptor for advanced glycation endproducts (RAGE). Activation of the AT1 receptor by angiotensin II (Ang II) triggered transactivation of the cytosolic tail of RAGE and NF-κB-driven proinflammatory gene expression independently of the liberation of RAGE ligands or the ligand-binding ectodomain of RAGE...
December 10, 2018: Journal of Clinical Investigation
Cristian Bonvicini, Catia Scassellati, Luisa Benussi, Emilio Di Maria, Carlo Maj, Miriam Ciani, Silvia Fostinelli, Anna Mega, Martina Bocchetta, Gaetana Lanzi, Edoardo Giacopuzzi, Sergio Ferraboli, Michela Pievani, Virginia Fedi, Carlo Alberto Defanti, Silvia Giliani, Giovanni Battista Frisoni, Roberta Ghidoni, Massimo Gennarelli
BACKGROUND: Early onset dementias (EOD) are rare neurodegenerative dementias that present before 65 years. Genetic factors have a substantially higher pathogenetic contribution in EOD patients than in late onset dementia. OBJECTIVE: To identify known and/or novel rare variants in major candidate genes associated to EOD by high-throughput sequencing. Common-risk variants of apolipoprotein E (APOE) and prion protein (PRNP) genes were also assessed. METHODS: We studied 22 EOD patients recruited in Memory Clinics, in the context of studies investigating genetic forms of dementia...
December 3, 2018: Journal of Alzheimer's Disease: JAD
Hayley Leeman, Elwira Kaminska, Deborah Green, Mark Bodman-Smith, Andrew Gravett, Katherine Bodman-Smith, John Copier, Gary Coulton, Alberto Fusi, Angus G Dalgleish
BACKGROUND: Despite the majority of patients do not gain any benefit from dendritic cells (DC) vaccines, this approach has occasionally given rise to dramatic responses in melanoma. Biomarkers are crucial to identify which patients are more likely to respond. We looked for correlations between pre- or post- vaccination biomarkers and clinical outcomes to DC therapy in a cohort of patients with stage IV melanoma receiving a vaccine with autologous ex-vivo expanded DCs pulsed with allogeneic tumor cell lysate...
December 7, 2018: Translational Oncology
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