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"Acute Pulmoary Oedema" OR "APO" OR "Acute Pulmonary Edema" OR "APE" OR "Acute Heart Failure Syndrome" OR "AHFS"

Miroslava Didiasova, Lukasz Wujak, Liliana Schaefer, Malgorzata Wygrecka
Factor XII (FXII) is a protease that is mainly produced in the liver and circulates in plasma as a single chain zymogen. Following contact with negatively charged surfaces, FXII is converted into the two-chain active form, FXIIa. FXIIa initiates the intrinsic blood coagulation pathway via activation of factor XI. Furthermore, it converts plasma prekallikrein to kallikrein (PK), which reciprocally activates FXII and liberates bradykinin from high molecular weight kininogen. In addition, FXIIa initiates fibrinolysis via PK-mediated urokinase activation and activates the classical complement pathway...
August 14, 2018: Cellular Signalling
Anna C Brezny, Clark R Landis
In the nearly 80 years since catalytic hydroformylation was first reported, hundreds of billions of pounds of aldehyde have been produced by this atom efficient one-carbon homologation of alkenes in the presence of H2 and CO. Despite the economy and demonstrated scalability of hydroformylation, the enantioselective process (asymmetric hydroformylation, AHF) currently does not contribute significantly to the production of chiral aldehydes and their derivatives. Current impediments to practical application of AHF include low diversity of chiral ligands that provide effective rates and selectivities, limited exploration of substrate scope, few demonstrations of efficient flow reactor processes, and incomplete mechanistic understanding of the factors that control reaction selectivity and rate...
August 17, 2018: Accounts of Chemical Research
Yoshihito Kitaoku, Gaston Courtade, Dejan M Petrović, Tamo Fukamizo, Vincent G H Eijsink, Finn L Aachmann
The apo-form of the 24.4 kDa AA9 family lytic polysaccharide monooxygenase TaLPMO9A from Thermoascus aurantiacus has been isotopically labeled and recombinantly expressed in Pichia pastoris. In this paper, we report the 1 H, 13 C, and 15 N chemical shift assignments, as well as an analysis of the secondary structure of the protein based on the secondary chemical shifts.
August 16, 2018: Biomolecular NMR Assignments
Therese Löhrich, Verena Behringer, Roman M Wittig, Tobias Deschner, Fabian H Leendertz
Pathogen analysis in wild great apes is both time- and resource-consuming. Therefore, we examined the potential use of urinary neopterin, a sensitive marker of cell-mediated immune system activation, as a disease marker and unspecific screening tool to facilitate informed pathogen analysis in great ape health monitoring. To test this, urinary neopterin was correlated to other disease markers such as sickness behaviors, fever, and urine parameters. Seasonal variation in urinary neopterin levels was investigated as well...
August 16, 2018: EcoHealth
Mevlut Demir, Pinar Turker Duyuler, Umit Guray, Muhammet Cihat Celik
BACKGROUND: Acute heart failure is a heterogenous syndrome defined by a number of factors, such as its physiopathology, clinical picture, time of onset, and relation to acute coronary syndrome. Acute cardiogenic pulmonary edema (ACPE) constitutes approximately 10-20% of acute heart failure syndromes, and it is the most dramatic symptom of left heart failure. Platelet to lymphocyte ratio (PLR) is a relatively novel inflammatory marker that can be utilized for prognosis in various disease processes...
August 13, 2018: Journal of Emergency Medicine
Yuquan Wang, Lanlan Li, Weibo Zhao, Yin Dou, Huijie An, Hui Tao, Xiaoqiu Xu, Yi Jia, Shan Lu, Jianxiang Zhang, Houyuan Hu
Atherosclerosis is a leading cause of vascular diseases worldwide. Whereas anti-oxidative therapy has been considered promising for the treatment of atherosclerosis in view of a critical role of reactive oxygen species (ROS) in the pathogenesis of atherosclerosis, currently available antioxidants showed considerably limited clinical outcomes. Herein we hypothesize that a broad-spectrum ROS-scavenging nanoparticle can serve as an effective therapy for atherosclerosis, taking advantages of its anti-oxidative stress activity and targeting effects...
August 16, 2018: ACS Nano
Sam George Bradley Roberts, Anna Ilona Roberts
The challenges of life in complex social groups may select for complex communication to regulate interactions among conspecifics. Whereas the association between social living and vocalizations has been explored in nonhuman primates, great apes also have a rich repertoire of gestures, and how the complexity of gestural communication relates to sociality is still unclear. We used social network analysis to examine the relationship between the duration of time pairs of chimpanzees spent in proximity (within 10 m) and the rates of gestural communication accompanied by visual attention of the signaler, one-to-one calls, indicative gestures (collectively self-relevance cues), and synchronized pant-hoot calls...
August 16, 2018: Journal of Comparative Psychology
Jorge I Vélez, Francisco Lopera, Penelope K Creagh, Laura B Piñeros, Debjani Das, Martha L Cervantes-Henríquez, Johan E Acosta-López, Mario A Isaza-Ruget, Lady G Espinosa, Simon Easteal, Gustavo A Quintero, Claudia Tamar Silva, Claudio A Mastronardi, Mauricio Arcos-Burgos
The identification of novel genetic variants contributing to the widespread in the age of onset (AOO) of Alzheimer's disease (AD) could aid in the prognosis and/or development of new therapeutic strategies focused on early interventions. We recruited 78 individuals with AD from the Paisa genetic isolate in Antioquia, Colombia. These individuals belong to the world largest multigenerational and extended pedigree segregating AD as a consequence of a dominant fully penetrant mutation in the PSEN1 gene and exhibit an AOO ranging from the early 1930s to the late 1970s...
August 15, 2018: Molecular Neurobiology
Lu Zhou, Xinjie Hui, Huijuan Yuan, Yinglin Liu, Yejun Wang
Objective: This study aimed to analyze the possible association between known genetic risks and preeclampsia in a Han Chinese population. Methods: A total of 156 patients with preeclampsia and 286 healthy Han Chinese women were enrolled and genotyped for 27 genetic alleles associated with preeclampsia in different populations. The association between the genotypes of the individual alleles and preeclampsia and the possible interaction among the alleles were analyzed...
2018: BioMed Research International
Vincenzo De Luca, Gianfranco Spalletta, Renan P Souza, Ariel Graff, Luciana Bastos-Rodrigues, Maria Aparecida Camargos Bicalho
BACKGROUND/OBJECTIVES: This study aims to investigate the role of apolipoprotein E (APOE) e4 influencing the age at onset (AAO) of Alzheimer's disease (AD). In AD, the AAO of dementia varies from 40 to 90 years. Usually, AD patients who develop symptoms before the age of 65 are considered as early-onset AD (EOAD). However, considering the heterogeneity of the AD onset, the definition of late-onset AD (LOAD) cannot rely on an arbitrary cut-off. Thus, we aim to validate the anticipation effect of the APOE e4 allele in LOAD...
August 15, 2018: Neuropsychobiology
Ryan S Atlasi, Ravinder Malik, Christian I Corrales, Laura Tzeplaeff, Julian P Whitelegge, Neil R Cashman, Gal Bitan
Mutations in Cu/Zn-superoxide dismutase (SOD1) gene are linked to 10-20% of familial amyotrophic lateral sclerosis (fALS) cases. The mutations cause misfolding and self-assembly of SOD1 into toxic oligomers and aggregates, resulting in motor neuron degeneration. The molecular mechanisms underlying SOD1 aggregation and toxicity are unclear. Characterization of misfolded SOD1 is particularly challenging due to its metastable nature. Antibodies against misfolded SOD1 are useful tools for this purpose, provided their specificity and selectivity are well characterized...
August 15, 2018: ACS Chemical Biology
Joshua C Bis, Xueqiu Jian, Brian W Kunkle, Yuning Chen, Kara L Hamilton-Nelson, William S Bush, William J Salerno, Daniel Lancour, Yiyi Ma, Alan E Renton, Edoardo Marcora, John J Farrell, Yi Zhao, Liming Qu, Shahzad Ahmad, Najaf Amin, Philippe Amouyel, Gary W Beecham, Jennifer E Below, Dominique Campion, Camille Charbonnier, Jaeyoon Chung, Paul K Crane, Carlos Cruchaga, L Adrienne Cupples, Jean-François Dartigues, Stéphanie Debette, Jean-François Deleuze, Lucinda Fulton, Stacey B Gabriel, Emmanuelle Genin, Richard A Gibbs, Alison Goate, Benjamin Grenier-Boley, Namrata Gupta, Jonathan L Haines, Aki S Havulinna, Seppo Helisalmi, Mikko Hiltunen, Daniel P Howrigan, M Arfan Ikram, Jaakko Kaprio, Jan Konrad, Amanda Kuzma, Eric S Lander, Mark Lathrop, Terho Lehtimäki, Honghuang Lin, Kari Mattila, Richard Mayeux, Donna M Muzny, Waleed Nasser, Benjamin Neale, Kwangsik Nho, Gaël Nicolas, Devanshi Patel, Margaret A Pericak-Vance, Markus Perola, Bruce M Psaty, Olivier Quenez, Farid Rajabli, Richard Redon, Christiane Reitz, Anne M Remes, Veikko Salomaa, Chloe Sarnowski, Helena Schmidt, Michael Schmidt, Reinhold Schmidt, Hilkka Soininen, Timothy A Thornton, Giuseppe Tosto, Christophe Tzourio, Sven J van der Lee, Cornelia M van Duijn, Badri Vardarajan, Weixin Wang, Ellen Wijsman, Richard K Wilson, Daniela Witten, Kim C Worley, Xiaoling Zhang, Celine Bellenguez, Jean-Charles Lambert, Mitja I Kurki, Aarno Palotie, Mark Daly, Eric Boerwinkle, Kathryn L Lunetta, Anita L Destefano, Josée Dupuis, Eden R Martin, Gerard D Schellenberg, Sudha Seshadri, Adam C Naj, Myriam Fornage, Lindsay A Farrer
The Alzheimer's Disease Sequencing Project (ADSP) undertook whole exome sequencing in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal controls primarily of European ancestry (EA), among whom 218 cases and 177 controls were Caribbean Hispanic (CH). An age-, sex- and APOE based risk score and family history were used to select cases most likely to harbor novel AD risk variants and controls least likely to develop AD by age 85 years. We tested ~1.5 million single nucleotide variants (SNVs) and 50,000 insertion-deletion polymorphisms (indels) for association to AD, using multiple models considering individual variants as well as gene-based tests aggregating rare, predicted functional, and loss of function variants...
August 14, 2018: Molecular Psychiatry
Hemant Kumar, Janet S Finer-Moore, Xiaoxu Jiang, Irina Smirnova, Vladimir Kasho, Els Pardon, Jan Steyaert, H Ronald Kaback, Robert M Stroud
The lactose permease of Escherichia coli (LacY), a dynamic polytopic membrane transport protein, catalyzes galactoside/H+ symport and operates by an alternating access mechanism that exhibits multiple conformations, the distribution of which is altered by sugar-binding. Camelid nanobodies were made against a double-mutant Gly46 → Trp/Gly262 → Trp (LacYWW ) that produces an outward-open conformation, as opposed to the cytoplasmic open-state crystal structure of WT LacY. Nanobody 9047 (Nb9047) stabilizes WT LacY in a periplasmic-open conformation...
August 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
Linyu Geng, Shiying Wang, Xia Li, Dandan Wang, Haifeng Chen, Jinyun Chen, Yue Sun, Weiwei Chen, Genhong Yao, Xiang Gao, Wanjun Chen, Songtao Shi, Xuebing Feng, Lingyun Sun
Patients with systemic lupus erythematosus (SLE) have a tremendously increased risk for cardiovascular disease (CVD), which could not be accounted in entirety by traditional Framingham risk factors. To study whether the accelerated atherosclerosis in SLE patients is mediated by type I interferon (IFN-I) through the regulation of endothelial progenitor cells (EPCs), we created a line of C57BL/6 mice with deficiency in both apolipoprotein E (ApoE-/-) and fas ligand (FasL-/-, gld.). As expected, the resultant gld...
August 11, 2018: Current Research in Translational Medicine
Niklas Mattsson, Oscar Eriksson, Olof Lindberg, Michael Schöll, Björn Lampinen, Markus Nilsson, Philip S Insel, Ronald Lautner, Olof Strandberg, Danielle van Westen, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Erik Stomrud, Oskar Hansson
Apolipoprotein (APOE) ε4 is a major genetic risk factor for Alzheimer's disease (AD), but its importance for the clinical and biological heterogeneity in AD is unclear, particularly at the prodromal stage. We analyzed 151 prodromal AD patients (44 APOE ε4-negative and 107 APOE ε4-positive) from the BioFINDER study. We tested cognition, 18F-flutemetamol β-amyloid (Aβ) positron emission tomography, cerebrospinal fluid biomarkers of Aβ, tau and neurodegeneration, and magnetic resonance imaging of white matter pathology and brain structure...
July 11, 2018: Neurobiology of Aging
Heidi Shoulders, Kaley H Garner, Dinender K Singla
Bone morphogenetic protein-7 (BMP-7) affects the presence of macrophage subtypes in vitro and in vivo at an early stage of atherosclerosis (ATH); however, it remains unknown whether BMP-7 treatment affects the development and progression of ATH at a mid-stage of the disease. We therefore performed a Day 28 (D28) study to examine BMP-7's potential to affect monocyte differentiation. Atherosclerosis was developed in ApoE KO mice, and these animals were treated with intravenous injections of BMP-7 and/or liposomal clondronate (LC)...
July 25, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
Tomohiro Yubi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Yoichiro Hirakawa, Daigo Yoshida, Seiji Gotoh, Naoki Hirabayashi, Yoshihiko Furuta, Tetsuro Ago, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya
Background: We investigated the prevalence of and risk factors for cerebral microbleeds (CMBs) in a cross-sectional study of a general population of Japanese elderly. Methods: In 2012, brain MRI scanning at 1.5T and comprehensive health examination were conducted for 1281 residents aged 65 years or older. CMBs were defined as ovoid hypointensity lesions less than 10 mm in diameter on T2*-weighted images and classified into deep/infratentorial or lobar CMBs. Age- and sex-specific and overall prevalence of CMBs were estimated, and the associations of traditional cardiovascular risk factors and APOE polymorphism with the presence of CMBs were examined using a logistic regression analysis...
June 2018: Neurology. Clinical Practice
Peter J Fernández, Carrie S Mongle, Louise Leakey, Daniel J Proctor, Caley M Orr, Biren A Patel, Sergio Almécija, Matthew W Tocheri, William L Jungers
The primate foot functions as a grasping organ. As such, its bones, soft tissues, and joints evolved to maximize power and stability in a variety of grasping configurations. Humans are the obvious exception to this primate pattern, with feet that evolved to support the unique biomechanical demands of bipedal locomotion. Of key functional importance to bipedalism is the morphology of the joints at the forefoot, known as the metatarsophalangeal joints (MTPJs), but a comprehensive analysis of hominin MTPJ morphology is currently lacking...
August 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
Michael Tomasello
To predict and explain the behavior of others, one must understand that their actions are determined not by reality but by their beliefs about reality. Classically, children come to understand beliefs, including false beliefs, at about 4-5 y of age, but recent studies using different response measures suggest that even infants (and apes!) have some skills as well. Resolving this discrepancy is not possible with current theories based on individual cognition. Instead, what is needed is an account recognizing that the key processes in constructing an understanding of belief are social and mental coordination with other persons and their (sometimes conflicting) perspectives...
August 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
Ling Gao, Yu Jiang, Shan Wei, Suhang Shang, Pei Li, Chen Chen, Liangjun Dang, Jin Wang, Kang Huo, Meiying Deng, Jingyi Wang, Rong Zhang, Qiumin Qu
BACKGROUND: Transport proteins, soluble low-density lipoprotein receptor-related protein-1 (sLRP1), and soluble receptor of advanced glycation end products (sRAGE), play an important role in the clearance of plasma amyloid-β (Aβ). However, their relationship is not clear. OBJECTIVE: The aim was to explore the relationship between plasma levels of sLRP1, sRAGE, and Aβ in a cross-sectional study. METHODS: A total of 1,185 cognitively normal participants (age above 40) from a village in the suburbs of Xi'an, China were enrolled from October 8, 2014 to March 30, 2015...
August 3, 2018: Journal of Alzheimer's Disease: JAD
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