George A Kanakis, Riccardo Pofi, Dimitrios G Goulis, Andrea M Isidori, Eleni Armeni, C Tamer Erel, Ivan Fistonić, Timothy Hillard, Angelica-Lindén Hirschberg, Blazej Meczekalski, Nicolás Mendoza, Alfred O Mueck, Tommaso Simoncini, Petra Stute, Dorenda van Dijken, Margaret Rees, Irene Lambrinoudaki
INTRODUCTION: Late-onset hypogonadism is the clinical entity characterised by low testosterone concentrations associated with clinical symptoms in the absence of organic disease in ageing men. It has been associated with metabolic syndrome, reduced bone mineral density, and increased cardiovascular morbidity and mortality risk. Although testosterone replacement therapy (TRT) reverses most of these conditions in young hypogonadal men, the risk/benefit ratio of TRT in older men is debatable...
December 2023: Maturitas