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https://www.readbyqxmd.com/read/28603900/mitochondrial-point-mutation-m-3243a%C3%A2-%C3%A2-g-associates-with-lower-bone-mineral-density-thinner-cortices-and-reduced-bone-strength-a-case-control-study
#1
Jakob Høgild Langdahl, Anja Lisbeth Frederiksen, Stinus Jørn Hansen, Per Heden Andersen, Knud Bonnet Yderstraede, Morten Dunø, John Vissing, Morten Frost
Mitochondrial dysfunction is associated with several clinical manifestations including diabetes, neurological disorders, renal and hepatic diseases and myopathy. While mitochondrial dysfunction is associated with increased bone resorption and decreased bone formation in mouse models, effects of alterations in mitochondrial function on bone remodelling and mass have not been investigated in humans. We recruited 45 carriers (29 females, 16 males) with the m.3243A > G mutation and healthy controls matched for gender, age, height and menopausal status...
June 11, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28515791/vildagliptin-has-the-same-safety-profile-as-a-sulfonylurea-on-bone-metabolism-and-bone-mineral-density-in-post-menopausal-women-with-type-2-diabetes-a-randomized-controlled-trial
#2
Andre Gustavo Daher Vianna, Claudio Silva de Lacerda, Luciana Muniz Pechmann, Michelle Garcia Polesel, Emerson Cestari Marino, Victoria Zeghbi Cochenski Borba, Fellype de Carvalho Barreto
BACKGROUND: Several antidiabetic therapies affect bone metabolism. Sulfonylureas have the lowest impact on bone among oral antidiabetics. The objective of this study is to compare the effects of vildagliptin and gliclazide modified release (MR) on bone turnover markers (BTMs) and bone mineral density (BMD) in postmenopausal women with uncontrolled type 2 diabetes (T2D). METHODS: Forty-two postmenopausal women with uncontrolled T2D were randomly allocated into vildagliptin or gliclazide MR (control) groups...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28428669/risk-factors-for-osteoporosis-in-postmenopausal-women
#3
Radojka Bijelic, Snjezana Milicevic, Jagoda Balaban
INTRODUCTION: Scientific studies show that many factors related to lifestyles affect the reduction of bone mineral density and osteoporosis in postmenopausal women. GOAL: The goal of this study was to determine whether smoking, drinking coffee and alcohol in menopausal women contribute to the reduction of bone mass and osteoporosis, as well as the impact of physical activity on bone mass. MATERIAL AND METHODS: The study was carried out as case study and matched controls...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28419209/estrogen-deficiency-exacerbates-type-1-diabetes-induced-bone-tnf%C3%AE-expression-and-osteoporosis-in-female-mice
#4
Sandi Raehtz, Hayley Bierhalter, Daniel Schoenherr, Narayanan Parameswaran, Laura R McCabe
Estrogen deficiency following menopause is associated with rapid bone loss, osteoporosis and increased fracture risk. Type 1 Diabetes (T1D), characterized by hypoinsulinemia and hyperglycemia, is also associated with bone loss and increased fracture risk. With better treatment options, T1D patients are living longer and therefore the number of patients having both T1D and estrogen deficiency is increasing. Little is known about the mechanistic impact of T1D in conjunction with estrogen deficiency on bone physiology and density...
April 14, 2017: Endocrinology
https://www.readbyqxmd.com/read/27809297/diabetes-and-obesity-as-independent-risk-factors-for-osteoporosis-updated-results-from-the-rois-emeros-registry-in-a-population-of-five-thousand-post-menopausal-women-living-in-a-region-characterized-by-heavy-environmental-pressure
#5
Cosimo Neglia, Alberto Argentiero, Giovanna Chitano, Nadia Agnello, Roberta Ciccarese, Antonella Vigilanza, Valerio Pantile, Domenico Argentiero, Raffaele Quarta, Matteo Rivezzi, Gian Luca Di Tanna, Carolina Di Somma, Alberto Migliore, Giovanni Iolascon, Francesca Gimigliano, Alessandro Distante, Prisco Piscitelli
Objectives: We aimed to analyze bone mineralization and the effect of different risk factors for osteoporosis in postmenopausal women. Methods: We found 4909 postmenopausal subjects within ≥10,000 records from the ROIS/EMEROS (Ionian and Salento Osteoporosis Registry/Euro Mediterranean Registry of Osteoporosis) registry, a population study carried out in an area characterized by heavy environmental pressure between Brindisi and Taranto from 2009 to 2016. All subjects were assessed via phalangeal quantitative ultrasound (QUS) to evaluate their bone mineralization (assessed via amplitude dependent speed of sound (AD-SoS)) and the association between demineralization and the presence of other conditions or risk factors...
November 1, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27666690/-hypoxemia-and-osteoporosis-possible-roles-of-hif1%C3%AE-on-respiratory-disease-related-osteoporosis
#6
REVIEW
Takeshi Miyamoto
Osteoporosis is a disease characterized by increased risks for bone fragility fractures, and is caused by various factors such as aging and menopause. Increase in the number of osteoporosis patients becomes a big concern in the developed countries. Recently, the mechanisms underlying postmenopausal osteoporosis development were being clarified, and several diseases such as respiratory diseases and diabetes were reportedly caused secondary osteoporosis. HIF1α was demonstrated required for osteoclast activation and bone loss in postmenopausal osteoporosis women...
2016: Clinical Calcium
https://www.readbyqxmd.com/read/27545638/-iron-based-phosphate-binders-for-esrd-patients
#7
Mario Cozzolino, Michela Mangano, Lorenza Magagnoli, Luca Di Lullo, Andrea Galassi, Diego Brancaccio, Antonio Bellasi
Several factors influence the choice of phosphate binder for patients, including older age, male gender, post-menopause, diabetes, low bone turnover, vascular/valvular calcification and inflammation. Unlike calcium-based phosphate binders, non-calcium-based phosphate binders, such as sevelamer and lanthanum carbonate, have been able to reduce the progression of bone disease to adynamic bone among patients with CKD. New iron-based phosphate binders are now available. With multiple options available for the reduction of phosphate, the focus has been on agents that do not contain calcium...
July 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/27475411/antim%C3%A3-llerian-hormone-among-women-with-and-without-type-1-diabetes-the-epidemiology-of-diabetes-interventions-and-complications-study-and-the-michigan-bone-health-and-metabolism-study
#8
Catherine Kim, Carrie Karvonen-Gutierrez, Shengchun Kong, Valerie Arends, Michael Steffes, Daniel S McConnell, John F Randolph, Siobán D Harlow
OBJECTIVE: To compare concentrations of antimüllerian hormone (AMH) in women with and without type 1 diabetes. DESIGN: Cross-sectional analysis of longitudinal studies, adjusting for repeated measures. SETTING: Not applicable. PATIENT(S): Women aged 30-45 years who had not undergone oophorectomy, hysterectomy, or natural menopause at the time of AMH measurement were included (n = 376 in the Michigan Bone Health and Metabolism Study and n = 321 in the Epidemiology of Interventions and Complications Study)...
November 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27445987/bone-marrow-adipose-tissue-to-be-or-not-to-be-a-typical-adipose-tissue
#9
REVIEW
Pierre Hardouin, Tareck Rharass, Stéphanie Lucas
Bone marrow adipose tissue (BMAT) emerges as a distinct fat depot whose importance has been proved in the bone-fat interaction. Indeed, it is well recognized that adipokines and free fatty acids released by adipocytes can directly or indirectly interfere with cells of bone remodeling or hematopoiesis. In pathological states, such as osteoporosis, each of adipose tissues - subcutaneous white adipose tissue (WAT), visceral WAT, brown adipose tissue (BAT), and BMAT - is differently associated with bone mineral density (BMD) variations...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27376424/vitamin-d-levels-in-a-large-mediterranean-cohort-reconsidering-normal-cut-off-values
#10
Marianna Katrinaki, Marilena Kampa, Andrew Margioris, Elias Castanas, Niki Malliaraki
OBJECTIVE: The determination of the normal range of 25-hydroxyvitamin D [25-(OH)D], though currently based on suppression of PTH levels, still remains a controversial issue. The 25-(OH)D levels exhibit gender and seasonal variability, the latter attributed in part to changes of insolation. DESIGN: The aim of this cross-sectional study was to estimate the levels of 25-(OH)D on the island of Crete and their correlation with metabolic, hormonal and bone turnover parameters...
April 2016: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27243136/association-between-insulin-resistance-and-bone-structure-in-nondiabetic-postmenopausal-women
#11
Vikram V Shanbhogue, Joel S Finkelstein, Mary L Bouxsein, Elaine W Yu
CONTEXT: The clinical consequences of insulin resistance and hyperinsulinemia on bone remain largely unknown. OBJECTIVE: The objective of the study was to evaluate the effect of insulin resistance on peripheral bone geometry, volumetric bone mineral density (vBMD), bone microarchitecture, and estimated bone strength. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study included 146 postmenopausal, nondiabetic Caucasian women (mean age 60...
August 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27095951/menopause-in-women-with-chronic-immunosuppressive-treatment-how-to-help-those-patients
#12
Anna Cyganek, Bronisława Pietrzak, Mirosław Wielgoś, Barbara Grzechocińska
Women after organ transplantation with chronic immunosuppressive therapy or after bone marrow transplantation without such therapy are a growing group of patients. Although their problems in the peri- and postmenopausal period are the same as in healthy women, due to the primary disease and treatment applied they represent a huge challenge from the point of view of their hormonal treatment of menopause. Transplanted women have no particular contraindications for hormonal therapy use. General contraindications, however, such as arterial hypertension, thrombosis in medical history, diabetes, endometriosis, myomas, or active neoplastic disease, have a higher incidence in this group of patients than in healthy women, which significantly influences the possibility of using hormonal therapy...
March 2016: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/27045342/higher-serum-ferritin-level-and-lower-femur-neck-strength-in-women-at-the-stage-of-bone-loss-%C3%A2-45-years-of-age-the-fourth-korea-national-health-and-nutrition-examination-survey-knhanes-iv
#13
Seong Hee Ahn, Seokhyeon Lee, Hyeonmok Kim, Seung Hun Lee, Beom-Jun Kim, Jung-Min Koh
PURPOSE: Despite the clear effect of iron on bone metabolism, most clinical studies related to bone health have only focused on bone mineral density (BMD). In the present study, we investigated the relationship between serum ferritin and composite indices of femur neck strength via a population-based, cross-sectional study using the Korea National Health and Nutrition Examination Survey (KNHANES). METHODS: Our study series included 693 women at the stage of bone loss (≥ 45 years of age), defined based on the observed patterns of age-related BMD changes in the KNHANES...
November 2016: Endocrine Research
https://www.readbyqxmd.com/read/27028261/alcohol-use-and-menopause
#14
Richard W Wilsnack, Sharon C Wilsnack
Clinicians should periodically assess their menopausal patients' alcohol use. Specific health hazards from excessive alcohol consumption, as well as potential benefits of low-level consumption (for cardiovascular disease, bone health, and type 2 diabetes), should be discussed with their patients who drink. The information in this Practice Pearl can help clinicians provide evidence-based guidance about alcohol consumption and its relationship to common health concerns.
April 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/26969749/bone-mineral-density-and-biochemical-markers-of-bone-metabolism-in-predialysis-patients-with-chronic-kidney-disease
#15
Nuri Fidan, Ayca Inci, Melahat Coban, Cevval Ulman, Seyhun Kursat
The aim of the study was to evaluate the usefulness of serum bone turnover markers (BTM) and bone mineral density (BMD) determined by dual-energy X-ray absorptiometry (DEXA) in predialysis patients with chronic kidney disease (CKD). We enrolled 83 patients with CKD, 41 (49.4%) males, 42 (50.6%) females, with mean estimated glomerular filtration rate (eGFR) 23.90 ± 12 (range = 6.0-56.0). BMD of the lumbar spine (LS) (anteroposterior, L2 through L4), femoral neck (FN) and femoral trochanter (FT) were measured by DEXA...
April 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/26620086/periodontal-disease-exacerbates-systemic-ovariectomy-induced-bone-loss-in-mice
#16
Ana Lia Anbinder, Renata M Moraes, Gabriela M G Lima, Felipe E Oliveira, Débora R C Campos, Rodnei D Rossoni, Luciane D Oliveira, Juliana C Junqueira, Yun Ma, Florent Elefteriou
Periodontal pathogens and/or inflammatory products from periodontitis participate in the development or progression of systemic diseases. In this context, periodontitis acts as a modifying factor to systemic health, including diabetes and cardiovascular diseases. Osteoporosis is an increasingly prevalent condition in our aging population and considered a risk factor for periodontal disease, but the effect of periodontitis on systemic bone homeostasis is unknown. We thus evaluated the effects of experimental periodontitis (EP) on systemic bone loss and the influence of estrogen deficiency in this context, using a mouse model of combined periodontitis and osteoporosis...
February 2016: Bone
https://www.readbyqxmd.com/read/26583038/influence-of-obesity-on-vertebral-fracture-prevalence-and-vitamin-d-status-in-postmenopausal-women
#17
A El Maghraoui, S Sadni, A El Maataoui, A Majjad, A Rezqi, Z Ouzzif, A Mounach
BACKGROUND: It is well established that weight is an important determinant of bone health. Whereas obesity is associated with increased mortality and morbidity from diabetes and cardiovascular diseases, high body weight is widely believed to be associated to hypovitaminosis D and protective against the development of osteoporosis and fracture risk. The objective of the study was to evaluate the effect of BMI on vitamin D status and on densitometric vertebral fractures (VFs) in a large series of asymptomatic women aged over 50 who had a VFA examination during their bone mineral density (BMD) testing...
2015: Nutrition & Metabolism
https://www.readbyqxmd.com/read/26215288/potential-protective-properties-of-flax-lignan-secoisolariciresinol-diglucoside
#18
Muhammad Imran, Nazir Ahmad, Faqir Muhammad Anjum, Muhammad Kamran Khan, Zarina Mushtaq, Muhammad Nadeem, Shahzad Hussain
Lignans are a group of phytonutrients which are widely distributed in the plant kingdom. Flaxseed is the richest source of providing lignan precursor such as secoisolariciresinol diglucoside (SDG). This article reviews the studies relevant to experimental models in animals and humans demonstrating the possible nutraceutical actions of SDG to prevent and alleviate lifestyle-related diseases. A local and international web-based literature review for this project was carried out to provide information relating to the study...
2015: Nutrition Journal
https://www.readbyqxmd.com/read/26204630/vitamin-d-deficiency-and-the-clinical-consequences
#19
Corina Galesanu, Veronica Mocanu
Vitamin D is important for good health, growth and strong bones. Vitamin D is mostly made in the skin by exposure to sunlight. Most foods contain very little vitamin D naturally, though some are fortified with added vitamin D. Hypovitaminosis D is associated with cardiovascular disease, the metabolic syndrome, type 2 diabetes mellitus, cancer as well as with increased mortality. Further, Vitamin D deficiency is related to depression and impaired cognitive function. Increasing age and elevated body fat mass contribute to an increased risk of Vitamin D deficiency...
April 2015: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
https://www.readbyqxmd.com/read/26112844/effect-of-oral-hypoglycaemic-agents-on-bone-metabolism-in-patients-with-type-2-diabetes-mellitus-occurrence-of-osteoporosis
#20
B Siddhartha Kumar, A Ravisankar, Alladi Mohan, D Prabath Kumar, D T Katyarmal, Alok Sachan, K V S Sarma
BACKGROUND & OBJECTIVES: Type 2 diabetes mellitus (T2DM) is considered to be a protective factor against development of osteoporosis. But oral hypoglycaemic agents (OHA) are likely to increase the risk of osteoporosis. This study was carried out to evaluate the effect of various OHA on bone mineral density (BMD) in patients with T2DM. METHODS: Forty one patients (study group) with T2DM (mean age 51.9±5.5 yr; 31 females) receiving treatment with oral hypoglycaemic agents (OHA) [thiazolidinediones alone (n=14) or in combination with other OHA (n=27)] for a period of at least three consecutive years and 41 age- and gender-matched healthy controls (mean age 51...
April 2015: Indian Journal of Medical Research
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