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Gestational hypertension

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https://www.readbyqxmd.com/read/29691249/hypertensive-pregnancy-complications-in-women-with-epilepsy-and-antiepileptic-drugs-a-population-based-cohort-study-of-first-pregnancies-in-norway
#1
Kim Christian Danielsson, Ingrid Borthen, Nils-Halvdan Morken, Nils Erik Gilhus
OBJECTIVES: To estimate the risk of hypertensive pregnancy complications in women with epilepsy, with and without antiepileptic drugs, and assess the risk associated with the four most common antiepileptic drugs. DESIGN: A population-based cohort study using linked data from the Medical Birth Registry of Norway and the Norwegian Prescription Database. Women with epilepsy with and without antiepileptic drugs were compared with women without epilepsy. SETTING: Norway, 2004-2012...
April 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29689321/gestational-weight-gain-and-weight-loss-among-women-with-gestational-diabetes-mellitus
#2
Daphna Komem, Lina Salman, Eyal Krispin, Nissim Arbib, Ron Bardin, Arnon Wiznitzer, Eran Hadar
AIMS: To assess the association of gestational weight gain or loss with adverse pregnancy outcome among women with gestational diabetes mellitus (GDM). METHODS: Retrospective study of all women diagnosed with GDM, from July 2012 to December 2016, stratified by gestational weight change according to the institute of medicine recommendations. Primary maternal outcome was glycemic control and primary neonatal outcome was large or small for gestational age (LGA or SGA)...
April 21, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29686379/maternal-early-pregnancy-obesity-and-related-pregnancy-and-pre-pregnancy-disorders-associations-with-child-developmental-milestones-in-the-prospective-predo-study
#3
Polina Girchenko, Soile Tuovinen, Marius Lahti-Pulkkinen, Jari Lahti, Katri Savolainen, Kati Heinonen, Riikka Pyhälä, Rebecca M Reynolds, Esa Hämäläinen, Pia M Villa, Eero Kajantie, Anu-Katriina Pesonen, Hannele Laivuori, Katri Räikkönen
BACKGROUND/OBJECTIVES: Previous studies have linked maternal pre-pregnancy obesity (BMI ≥30 kg/m2 ) with suboptimal neurodevelopment in her offspring; however, the literature is not entirely consistent. Whether these effects are muddled by maternal self-reports of pre-pregnancy weight and height, or are driven or amplified by the well often comorbid hypertensive and diabetic pregnancy and pre-pregnancy disorders, remains unclear. We examined whether maternal early pregnancy obesity is associated with developmental delay in her offspring, and if the associations are driven or amplified by diabetic and hypertensive pregnancy and pre-pregnancy disorders...
April 23, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29686018/serum-and-urine-thioflavin-t-enhanced-fluorescence-in-severe-preeclampsia
#4
Katherine R Millen, Catalin S Buhimschi, Guomao Zhao, Kara M Rood, Sammy Tabbah, Irina A Buhimschi
Common features of amyloid-like proteotoxic aggregates are the ability to bind Congo red (congophilia) and to induce fluorescence of thioflavin-T (ThT). Based on the prior discovery that women with preeclampsia exhibit urine congophilia, we proposed that amyloid-like protein aggregates present in urine also circulate in the bloodstream and this feature is linked to disease severity and clinical phenotype. ThT fluorescence was investigated in 217 paired serum and urine samples from women with severe features of preeclampsia (n=101; median [interquartile range] gestational age [GA], 32 [29-35] weeks), mild features of preeclampsia (n=22; GA, 36 [36-37] weeks), chronic hypertension (n=15; GA, 38 [37-39] weeks), healthy pregnant controls (n=57; GA, 39 [38-39] weeks), and nonpregnant controls (n=22)...
April 23, 2018: Hypertension
https://www.readbyqxmd.com/read/29686009/influence-of-gestational-age-at-initiation-of-antihypertensive-therapy-secondary-analysis-of-chips-trial-data-control-of-hypertension-in-pregnancy-study
#5
Anouk Pels, Ben Willem J Mol, Joel Singer, Terry Lee, Peter von Dadelszen, Wessel Ganzevoort, Elizabeth Asztalos, Laura A Magee
For hypertensive women in CHIPS (Control of Hypertension in Pregnancy Study), we assessed whether the maternal benefits of tight control could be achieved, while minimizing any potentially negative effect on fetal growth, by delaying initiation of antihypertensive therapy until later in pregnancy. For the 981 women with nonsevere, chronic or gestational hypertension randomized to less-tight (target diastolic blood pressure, 100 mm Hg), or tight (target, 85 mm Hg) control, we used mixed-effects logistic regression to examine whether the effect of less-tight (versus tight) control on major outcomes was dependent on gestational age at randomization, adjusting for baseline factors as in the primary analysis and including an interaction term between gestational age at randomization and treatment allocation...
April 23, 2018: Hypertension
https://www.readbyqxmd.com/read/29681194/exposure-to-different-intrauterine-environments-implications-for-telomere-attrition-in-early-life
#6
Isabel Cristina Ribas Werlang, Monique Cabral Hahn, Juliana Rombaldi Bernardi, Martha Nast, Marcelo Zubaran Goldani, Mariana Bohns Michalowski
OBJECTIVE: Studies focusing on telomere attrition in newborns and what factors could be involved in this issue are sparse; most reports have been in adult populations. Thereby, the aim of this study was to present an overview of what is currently known about the relationship between environmental exposure of the fetus during pregnancy and telomere length outcomes in early life. METHODS: The MEDLINE (via PubMed) and Bireme databases were searched for studies published until 1 June, 2016...
April 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29680782/usefulness-of-blood-pressure-monitoring-in-patients-with-gestational-diabetes-mellitus
#7
Begoña Sánchez-Lechuga, Almudena Lara-Barea, Juan Antonio Córdoba-Doña, Ana Montero Galván, Alicia Abal Cruz, Manuel Aguilar-Diosdado, Cristina López-Tinoco
BACKGROUND AND OBJECTIVE: Gestational diabetes mellitus (GDM) is associated to an increased risk of pregnancy-induced hypertension (PIH). Ambulatory blood pressure monitoring (ABPM) has been used to detect PIH and preeclampsia, but few data are currently available on its use in women with GDM. The aim of this study was to achieve early identification in women with GDM of BP profiles (detected by ABPM) that could define a population at greater risk of developing PIH and preeclampsia. MATERIAL AND METHODS: A prospective study of 93 normotensive women with GDM in whom 24-h ABPM was performed (using a Spacelabs 90207 monitor) at 28-32 weeks of pregnancy...
April 18, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29679628/long-and-short-term-outcomes-of-gestational-diabetes-mellitus-gdm-among-south-asian-women-a-community-based-study
#8
REVIEW
B H Sudasinghe, C N Wijeyaratne, P S Ginige
AIMS: To quantify short and long-term outcomes of Gestational Diabetes Mellitus (GDM) among South Asians METHODS: Prospective cohort-study in Gampaha District, Sri Lanka following a community-prevalence study (WHO 1999 criteria). All women with GDM (exposed) and within sample non-GDM (non-exposed) were recruited. Data was gathered at selected intervals until one-year post-partum by interviewer-administered questionnaire, anthropometry, blood pressure, post-partum 75gOGTT and cholesterol...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29677687/endothelial-dysfunction-as-a-long-term-effect-of-late-onset-hypertensive-pregnancy-disorders-high-bmi-is-key
#9
L J Alma, C J M De Groot, R X De Menezes, W Hermes, P L Hordijk, I Kovačević
OBJECTIVE: Hypertensive disorders during pregnancy increase cardiovascular risk later in life by 2 to 9-fold. Endothelial activation is one of the underlying mechanisms of cardiovascular risk. Therefore, we decided to investigate endothelial activation in primiparous women, 2.5 years after a hypertensive pregnancy disorder. STUDY DESIGN: Plasma samples were taken from women 2.5 years after gestational hypertension (GH) or late onset preeclampsia (cases) and from women 2...
April 12, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29675495/maternal-history-and-uterine-artery-wave-form-in-the-prediction-of-early-onset-and-late-onset-preeclampsia-a-cohort-study
#10
Nidhi Sharma, Krishnamurthy Jayashree, Kulasekaran Nadhamuni
Background: Pregnancy induced hypertension (PIH) is a significant cause of maternal morbidity and mortality. Pregnancy-induced-hypertension can be prevented by identification of prenatal and antenatal factors. The uterine artery Doppler waveform transforms into a high flow with low resistance at 22-24 wk. Objective: To study the maternal risk factors and uterine artery Doppler waveform in singleton mid-trimester pregnancy and predict the occurrence of pregnancy-induced hypertension ...
February 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29675491/hypertensive-disorders-of-in-vitro-fertilization-pregnancies-a-study-from-kosovo
#11
Merita Vuniqi-Krasniqi, Myrvete Paçarada, Qëndresë Daka, Zeqir Dervishi, Astrit Bimbashi, Kushtrim Dakaj
Background: Relationships between in-vitro fertilization (IVF), gestational hypertension, and pregnancy outcomes are demonstrated in a number of studies. However, it is still debated if IVF treatment or specific characteristics of infertile patients are responsible for worse obstetrical and neonatal outcomes. Objective: The aim of this study was to investigate maternal characteristics associated with hypertensive disorders (HD) in IVF conceived pregnancies and to assess the obstetrical and neonatal outcomes...
February 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29674207/impact-of-excessive-pre-pregnancy-body-mass-index-and-abnormal-gestational-weight-gain-on-pregnancy-outcomes-in-women-with-chronic-hypertension
#12
Sara Ornaghi, Paola Algeri, Lyudmyla Todyrenchuk, Emanuela Vertemati, Patrizia Vergani
OBJECTIVES: To investigate the effects of excessive pre-pregnancy body mass index (BMI) and abnormal gestational weight gain on adverse outcomes in women with chronic hypertension (CH). STUDY DESIGN: A retrospective cohort study of CH women with singleton pregnancy delivered at our Institution in 2002-2013. Women were categorized as normal, overweight, and obese, according to their pre-pregnancy BMI. Further stratification was based on gestational weight gain (insufficient, adequate, and excessive) as defined by 2009 IOM guidelines...
April 10, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29674192/predictive-value-of-sflt-1-plgf-sflt-1-plgf-ratio-and-papp-a-for-late-onset-preeclampsia-and-iugr-between-32-and-37-weeks-of-pregnancy
#13
C Birdir, L Droste, L Fox, M Frank, J Fryze, A Enekwe, A Köninger, R Kimmig, B Schmidt, A Gellhaus
OBJECTIVES: The aim of this study was to investigate, whether maternal serum levels of sFlt-1, PlGF and PAPP-A at third trimester of pregnancy are associated with late-onset PE and intrauterine growth retardation (IUGR) after 34 weeks of pregnancy. METHODS: This was a prospective study measuring the maternal serum levels of soluble tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF) and pregnancy-associated plasma protein-A (PAPP-A) at 32-37 weeks of pregnancy: 730 patients were enrolled and 676 had neither intrauterine growth restriction (IUGR) nor preeclampsia (PE) or pregnancy induced hypertension (PIH) throughout the pregnancy...
April 11, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29674191/seasonality-of-hypertensive-disorders-of-pregnancy-a-south-australian-population-study
#14
Petra E Verburg, Gus A Dekker, Graeme Tucker, Wendy Scheil, Jan Jaap H M Erwich, Claire T Roberts
OBJECTIVES: To investigate the seasonal variation of hypertensive disorders of pregnancy (HDP) in South Australia. STUDY DESIGN: Retrospective population study including all 107,846 liveborn singletons during 2007-2014 in South Australia. Seasonality in incidence of HDP in relation to estimated date of conception (eDoC) and date of birth (DoB) were examined using Fourier series analysis. MAIN OUTCOME MEASURES: Seasonality of HDP in relation to eDoC and DoB...
April 11, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29674190/urinary-angiotensinogen-excretion-in-australian-indigenous-and-non-indigenous-pregnant-women
#15
Kirsty G Pringle, Celine Corbisier de Meaultsart, Shane D Sykes, Loretta J Weatherall, Lyniece Keogh, Don C Clausen, Gus A Dekker, Roger Smith, Claire T Roberts, Kym M Rae, Eugenie R Lumbers
The intrarenal renin-angiotensin system (iRAS) is implicated in the pathogenesis of hypertension, chronic kidney disease and diabetic nephropathy. Urinary angiotensinogen (uAGT) levels reflect the activity of the iRAS and are altered in women with preeclampsia. Since Indigenous Australians suffer high rates and early onset of renal disease, we hypothesised that Indigenous Australian pregnant women, like non-Indigenous women with pregnancy complications, would have altered uAGT levels. The excretion of RAS proteins was measured in non-Indigenous and Indigenous Australian women with uncomplicated or complicated pregnancies (preeclampsia, diabetes/gestational diabetes, proteinuria/albuminuria, hypertension, small/large for gestational age, preterm birth), and in non-pregnant non-Indigenous women...
April 11, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29673331/prevalence-and-factors-associated-with-preterm-birth-at-kenyatta-national-hospital
#16
Peter Wagura, Aggrey Wasunna, Ahmed Laving, Dalton Wamalwa, Paul Ng'ang'a
BACKGROUND: The World Health Organization estimates the prevalence of preterm birth to be 5-18% across 184 countries of the world. Statistics from countries with reliable data show that preterm birth is on the rise. About a third of neonatal deaths are directly attributed to prematurity and this has hindered the achievement of Millennium Development Goal-4 target. Locally, few studies have looked at the prevalence of preterm delivery and factors associated with it. This study determined the prevalence of preterm birth and the factors associated with preterm delivery at Kenyatta National Hospital in Nairobi, Kenya...
April 19, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29673002/incidence-of-and-risk-factors-for-severe-maternal-complications-associated-with-hypertensive-disorders-after-36-weeks-gestation-in-uncomplicated-twin-pregnancies-a-prospective-cohort-study
#17
Ryo Yamamoto, Keisuke Ishii, Haruka Muto, Shiyo Ota, Haruna Kawaguchi, Shusaku Hayashi, Nobuaki Mitsuda
AIM: To elucidate the incidence of and risk factors for severe hypertensive disorders (HD) and related maternal complications in uncomplicated twin pregnancies that reached 36 weeks' gestation. METHODS: We conducted a prospective cohort study of twin pregnancies delivered after 36 weeks' gestation. Cases of twin-twin transfusion syndrome, twin anemia-polycythemia sequence, malformed fetuses, monoamniotic twins, selective reduction, fetal therapy and HD or fetal death before 35 weeks' gestation were excluded...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29666681/implications-of-early-pregnancy-obesity-on-maternal-fetal-and-neonatal-health-retrospective-cohort-study-from-oman
#18
Anita Zutshi, Jayasree Santhosh, Julie Sheikh, Fareeha Naeem, Ahmed Al-Hamedi, Shahla Khan, Eishthiag Al-Said
Objectives: This study aimed to determine the prevalence of early pregnancy obesity among Omani women and to review maternal antenatal complications, intrapartum and postpartum events and neonatal complications among such women in comparison to women of normal weight. Methods: This retrospective cohort study included 2,652 pregnant Omani women who delivered at the Royal Hospital, Muscat, Oman, between November 2011 and April 2012. The patients' electronic medical records were reviewed for antenatal, intrapartum and postpartum data...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29660382/elevated-plasma-soluble-pro-renin-receptor-levels-are-associated-with-left-ventricular-remodeling-and-renal-function-in-chronic-heart-faiure-patients-with-reduced-ejection-fraction
#19
Linghui Gong, Shenglin Zhang, Linrui Li, Xin Gao, Dongxia Wang, Dachang Wu, Ke Wang, Yan Liu
Soluble (pro)renin receptor [s(P)RR], which is generated from cleavage of (P)RR, can be detected in plasma and urine. s(P)RR levels can reflect the severity of some diseases, such as renal lesions, gestational diabetes mellitus or hypertension, and obstructive sleep apnea syndrome. However, the relationship between s(P)RR levels and the severity of chronic heart failure remains undetermined. We studied s(P)RR levels in 118 patients with chronic heart failure with reduced ejection fraction (HFrEF), including 86 without renal dysfunction (HF) and 32 with renal dysfunction (HF + RF), and 28 healthy subjects (HS) to reveal the relationship between s(P)RR levels and other HFrEF parameters...
April 13, 2018: Peptides
https://www.readbyqxmd.com/read/29660063/five-successful-pregnancies-with-antenatal-anakinra-exposure
#20
Chelsey J F Smith, Christina D Chambers
Objectives: Our aim is to add to the limited existing prospective data on IL-1 inhibitor use in pregnancy. Methods: Data were obtained from the Organization of Teratology Information Specialists Autoimmune Disease in Pregnancy Project, a prospective cohort study of pregnancy outcomes in the USA and Canada. Eligible women were enrolled prior to 19 weeks' gestation between 2004 and 2017. Outcomes were obtained by maternal interview and medical record abstraction. Results: Five pregnancies with anakinra exposure were identified, all resulting in full-term singleton live births with no major or long-term complications...
April 12, 2018: Rheumatology
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