keyword
https://read.qxmd.com/read/38499481/one-stage-versus-two-stage-endoscopic-management-for-acute-cholangitis-caused-by-common-bile-duct-stones-a-retrospective-multicenter-cohort-study
#21
JOURNAL ARTICLE
Akinori Maruta, Takuji Iwashita, Kensaku Yoshida, Yuhei Iwasa, Mitsuru Okuno, Keisuke Iwata, Ryuichi Tezuka, Shinya Uemura, Shogo Shimizu, Masahito Shimizu
BACKGROUND: One-stage endoscopic management, where papillary interventions and stone removal are simultaneously performed, has been reported to be an effective treatment for acute cholangitis caused by common bile duct stones (CBDS). However, there have been few reports comparing it with two-stage management, and there is no established strategy for the indication of one-stage management. The aim of the present study was to compare the short- and long-term outcomes between one- and two-stage management for acute cholangitis caused by CBDS...
March 18, 2024: Journal of Hepato-biliary-pancreatic Sciences
https://read.qxmd.com/read/38494502/the-natural-history-and-burden-of-illness-of-metachromatic-leukodystrophy-a-systematic-literature-review
#22
REVIEW
Shun-Chiao Chang, Christian Stefan Eichinger, Polly Field
BACKGROUND: Metachromatic leukodystrophy (MLD; OMIM 250100 and 249900) is a rare lysosomal storage disease caused by deficient arylsulfatase A activity, leading to accumulation of sulfatides in the nervous system. This systematic literature review aimed to explore the effect of MLD on the lives of patients. METHODS: The Ovid platform was used to search Embase, MEDLINE, and the Cochrane Library for articles related to the natural history, clinical outcomes, and burden of illness of MLD; congress and hand searches were performed using 'metachromatic leukodystrophy' as a keyword...
March 18, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38493667/biliary-tract-cancers-french-national-clinical-practice-guidelines-for-diagnosis-treatments-and-follow-up-tncd-snfge-ffcd-unicancer-gercor-sfcd-sfed-afef-sfro-sfp-sfr-acabi-achbpt
#23
REVIEW
Gael S Roth, Loic Verlingue, Matthieu Sarabi, Jean-Frédéric Blanc, Emmanuel Boleslawski, Karim Boudjema, Anne-Laure Bretagne-Bignon, Marine Camus-Duboc, Romain Coriat, Gilles Créhange, Thierry De Baere, Christelle de la Fouchardière, Clarisse Dromain, Julien Edeline, Maximiliano Gelli, Boris Guiu, Samy Horn, Valérie Laurent-Croise, Côme Lepage, Astrid Lièvre, Anthony Lopez, Sylvain Manfredi, Julie Meilleroux, Cindy Neuzillet, Valérie Paradis, Frédéric Prat, Maxime Ronot, Olivier Rosmorduc, Antonio Sa Cunha, Olivier Soubrane, Anthony Turpin, Christophe Louvet, Olivier Bouché, David Malka
INTRODUCTION: This document is a summary of the French intergroup guidelines of the management of biliary tract cancers (BTC) (intrahepatic, perihilar and distal cholangiocarcinomas, and gallbladder carcinomas) published in September 2023, available on the website of the French Society of Gastroenterology (SNFGE) (www.tncd.org). METHODS: This collaborative work was conducted under the auspices of French medical and surgical societies involved in the management of BTC...
March 13, 2024: European Journal of Cancer
https://read.qxmd.com/read/38487949/efficacy-and-predictors-of-immune-checkpoint-inhibitors-in-patients-with-gallbladder-cancer
#24
JOURNAL ARTICLE
Zhuo Cheng, Cheng Yang, Qian Zhao, Jingjiao Zhong, Jin Zhang, Riming Jin, Yao Li, Na Ta, Dong Wu, Zhengang Yuan, Wen Sun, Ruoyu Wang
Immune checkpoint inhibitors (ICIs) have shown promising efficacy in multiple cancers including biliary tract cancers (BTCs). However, the data focusing on the efficacy of ICIs in patients with gallbladder cancer (GBC) is still limited. In this study, we aim to assess the efficacy of ICIs in GBC and explore the clinicopathologic and molecular markers associated with ICI benefit. We retrospective analyzed 69 GBC patients who had received ICI therapy between January 2016 and December 2020. Tumor samples were obtained for genomic sequencing and immunohistochemical analysis...
March 15, 2024: Cancer Science
https://read.qxmd.com/read/38482216/hepatic-arterial-infusion-chemotherapy-combined-with-bevacizumab-plus-a-pd-1-inhibitor-for-gallbladder-cancer-with-hepatic-oligometastasis-a-real-world-study
#25
JOURNAL ARTICLE
Wenchao Zhao, Zhiyuan Yao, Jingbo Li, Wenping Li, Qi Dou, Xiangfei Zhao, Yintao Wu, Nianxin Xia
BACKGROUND: Gallbladder cancer (GBC) is different from other biliary tract cancers in terms of molecular phenotype and microenvironment. Specific treatments for GBC need to be urgently explored. This study preliminarily investigated the clinical value of hepatic artery infusion chemotherapy (HAIC) combined with bevacizumab plus a programmed death receptor-1 (PD-1) inhibitor for treatment of GBC with hepatic oligometastasis. METHODS: We retrospectively collected data on GBC patients with hepatic oligometastasis, who received this combination therapy...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38476609/metastatic-gallbladder-cancer-presenting-as-numb-chin-syndrome-a-case-report-and-literature-review
#26
Makoto Murahashi, Edward Hosea Ntege, Kentaro Ide, Nobuyuki Maruyama, Jumpei Shirakawa, Hiroki Koyama, Toshihiro Kawano, Takahiro Goto, Yusuke Shimizu, Kazuhide Nishihara, Hiroyuki Nakamura
Gallbladder cancer (GBC) is an uncommon malignancy that is highly aggressive in the advanced stages. However, it rarely metastasizes to the mandible. Numb chin syndrome (NCS) is a rare neurological manifestation associated with various underlying causes, including occult primary cancers and distant metastases. It is often considered to be a significant indicator of malignancy, and thorough investigation is essential in the presence of unclear etiology. The current study reported on the case of a 69-year-old Japanese woman who presented with numbness and mild pain in the lower lip and chin area for three months...
April 2024: Biomedical Reports
https://read.qxmd.com/read/38475671/role-of-advanced-endoscopy-in-the-management-of-inflammatory%C3%A2-digestive-diseases-pancreas-and-biliary-tract
#27
REVIEW
Toshiharu Ueki, Toru Maruo, Yoshinori Igarashi, Akira Yamamiya, Keiichi Tominaga, Atsushi Irisawa, Hitoshi Yoshida, Terumi Kamisawa, Mamoru Takenaka, Hiroyuki Isayama
The progress of endoscopic diagnosis and treatment for inflammatory diseases of the biliary tract and pancreas have been remarkable. Endoscopic ultrasonography (EUS) and EUS-elastography are used for the diagnosis of early chronic pancreatitis and evaluation of endocrine and exocrine function in chronic pancreatitis. Notably, extracorporeal shock wave lithotripsy and electrohydraulic shock wave lithotripsy have improved the endoscopic stone removal rate in patients for whom pancreatic stone removal is difficult...
March 12, 2024: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://read.qxmd.com/read/38472947/the-many-hidden-faces-of-gallbladder-carcinoma-on-ct-and-mri-imaging-from-a-to-z
#28
JOURNAL ARTICLE
Damaris Neculoiu, Lavinia Claudia Neculoiu, Ramona Mihaela Popa, Rosana Mihaela Manea
Gallbladder carcinoma represents the most aggressive biliary tract cancer and the sixth most common gastrointestinal malignancy. The diagnosis is a challenging clinical task due to its clinical presentation, which is often non-specific, mimicking a heterogeneous group of diseases, as well as benign processes such as complicated cholecystitis, xanthogranulomatous cholecystitis, adenomyomatosis, porcelain gallbladder or metastasis to the gallbladder (most frequently derived from melanoma, renal cell carcinoma)...
February 22, 2024: Diagnostics
https://read.qxmd.com/read/38469806/ercp-for-common-bile-duct-stones-in-the-elderly-refine-the-procedure-to-improve-outcomes
#29
JOURNAL ARTICLE
Jesús García-Cano, Miriam Viñuelas Chicano, Laura Valiente González
Removal of common bile duct stones in patients with a previous cholecystectomy was one of the first indications for ERCP with biliary sphincterotomy. Thanks to a minimally invasive procedure, patients were prevented from having a new operation. Subsequently, as the technique proved to be successful, ERCP was extended to all patients with choledocholithiasis, regardless of whether or not they had gallbladder. Also contributing was the fact that, at least in the beginnings, surgical interventions on the bile duct with laparoscopic cholecystectomy were more difficult...
March 12, 2024: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/38465981/nonmalignant-68ga-fapi-46-uptake-in-2-cases-of-tenis-syndrome-comparison-with-18f-fdg
#30
JOURNAL ARTICLE
Farivash Karamian, Ramin Sadeghi, Atena Aghaee, Emran Askari, Hessamoddin Roustaei
The cancer specificity of fibroblast activation protein inhibitor (FAPI) uptake remains understudied topic, and several cases of false-positive FAPI PET/CT findings have been reported. We present 2 patients of differentiated thyroid cancer with thyroglobulin elevation and negative iodine scintigraphy syndrome who underwent 68Ga-FAPI PET/CT and 18F-FDG PET/CT for evaluation of any possible sites for metastatic disease. Although no focus of metastatic disease was found in these patients, remarkable findings were noticed instead...
March 7, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38465030/acute-cholecystitis-complicating-cardiac-disease-a-cohort-study-from-a-tertiary-care-center-in-mexico-city-mexico
#31
JOURNAL ARTICLE
Fernando Alonso Núñez Moreno, Vanessa Ortiz Higareda, Luis León Hernández Trejo, Lissvia Estéfani Acosta Gaxiola
Background Acute cholecystitis (AC) presents as inflammation of the gallbladder, predominantly attributed to gallstones obstructing the cystic duct. Another notable etiology is ischemic cholecystitis, often stemming from severe illnesses that compromise blood flow to the splanchnic system. Individuals with pre-existing cardiovascular conditions or undergoing cardiopulmonary surgery encounter elevated risks of gastrointestinal pathology, leading to heightened morbidity and mortality rates. In these cases, AC stands out as a significant concern, whether it originates from gallstones or is acalculous (ischemic)...
February 2024: Curēus
https://read.qxmd.com/read/38464911/mirizzi-syndrome-the-trojan-horse-of-gallbladder-disease
#32
JOURNAL ARTICLE
Mary Froehlich, Elizabeth M Sodomin, Taylor Fontenot, Noama Iftekhar, Christian N Chan, Annabel Barber
BACKGROUND: The incidence of Mirizzi Syndrome ranges from 0.05 to 5.7 % of patients who undergo cholecystectomy. The purpose of this study is to examine the preoperative workup and postoperative outcomes for patients diagnosed with Mirizzi Syndrome. METHODS: Retrospective chart review was conducted between January 2018 and January 2022 at a single institution. All adult patients who underwent cholecystectomy were included. RESULTS: 1628 patients underwent cholecystectomy of which 47 were diagnosed with Mirizzi Syndrome...
March 2024: Surgery open science
https://read.qxmd.com/read/38463373/spilled-gallstone-mimicking-intra-abdominal-seeding-of-gallbladder-adenocarcinoma-a-case-report
#33
Cheng-Ken Huang, Ruey-Hwa Lu, Chien-Cheng Chen, Po-Chun Chen, Wen-Chang Hsu, Meng-Jui Tsai, Chin-Tsung Ting
BACKGROUND: Gallbladder rupture is common in laparoscopic cholecystectomy because the gallbladder is usually in acute or chronic inflammation status. The gallstones may sometime be spilled into the peritoneal cavity, resulting in intra-abdominal abscess if the gallstones were not retrieved. The diagnosis of intra-abdominal abscess caused by unretrieved gallstone can usually be correctly identified in the routine imaging studies, such as abdominal ultrasonography or computed tomography (CT)...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38457070/a-case-of-progressive-xanthogranulomatous-pancreatitis-with-splenic-abscess
#34
JOURNAL ARTICLE
Keiji Nagata, Kojiro Nakamura, Taku Iida, Junji Iwasaki, Ryo Ito, Satsuki Asai, Misa Ishihara, Toshiyuki Hata, Atsushi Itami, Takahisa Kyogoku
Xanthogranulomatous inflammation is a chronic inflammatory reaction microscopically characterized by aggregation of foamy histiocytes, fibrous tissue, and infiltration of various inflammatory cells. In contrast to xanthogranulomatous inflammation in the gallbladder or kidney, xanthogranulomatous pancreatitis is rare. We herein present a case of xanthogranulomatous pancreatitis in a patient who underwent distal pancreatectomy with splenectomy under preoperative suspicion of a pancreatic pseudocyst or pancreatic tumor...
March 8, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38455808/xanthogranulomatous-salpingo-oophoritis-as-a-rare-presentation-in-pelvic-inflammatory-disease
#35
Manupriya Sharma, Renu Singh, Poojan Marwaha, Deychen Myes, Nisha Malik
Xanthogranulomatous salpingo-oophoritis is an infrequent and challenging inflammatory condition of the female genital tract. It involves the destruction of the fallopian tube and ovarian tissue by infiltrating inflammatory cells comprising lipid-laden macrophages, lymphocytes, plasma cells, and multinucleated giant cells. While more commonly found in other organs like the gallbladder and kidney, its occurrence in the female genital tract is rare. We present a case of xanthogranulomatous salpingo-oophoritis in a 45-year-old woman, shedding light on its diagnostic and clinical complexities...
February 2024: Curēus
https://read.qxmd.com/read/38448828/investigating-the-mortality-trend-of-gastrointestinal-cancers-in-babol-north-iran-2013-2021
#36
JOURNAL ARTICLE
Pouyan Ebrahimi, Mohsen Karami, Sahar Delavari, Layla Shojaie, Seyed-Hossein Hosseini-Berneti, Fatemeh Bayani, Mehdi Moghaddasi, Ozra Babazade, Hossein-Ali Nikbakht
BACKGROUND AND AIM: This study aims to examine the mortality rate and trend of gastrointestinal cancers, particularly gastric cancer, as the leading cause of death among cancers in northern Iran over a 9-year period. In light of the changing incidence and mortality rates of cancer in Iran and around the world, the importance of these diseases in people's lives, and the necessity of updating and monitoring the trend of cancer mortality, we have decided to report on the mortality trend of gastrointestinal cancers, based on crude and age-standardized rates...
March 6, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38444942/the-anticancer-activity-of-bile-acids-in-drug-discovery-and-development
#37
REVIEW
Weijian Li, Lu Zou, Shuai Huang, Huijie Miao, Ke Liu, Yajun Geng, Yingbin Liu, Wenguang Wu
Bile acids (BAs) constitute essential components of cholesterol metabolites that are synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the biliary system. They play a crucial role in nutrient absorption, lipid and glucose regulation, and the maintenance of metabolic homeostasis. In additional, BAs have demonstrated the ability to attenuate disease progression such as diabetes, metabolic disorders, heart disease, and respiratory ailments. Intriguingly, recent research has offered exciting evidence to unveil their potential antitumor properties against various cancer cell types including tamoxifen-resistant breast cancer, oral squamous cell carcinoma, cholangiocarcinoma, gastric cancer, colon cancer, hepatocellular carcinoma, prostate cancer, gallbladder cancer, neuroblastoma, and others...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38444075/single-incision-laparoscopic-cholecystectomy-using-a-set-of-novel-needle-instruments
#38
JOURNAL ARTICLE
Zhengmin Cui, Duoqiang Zhang, Mingguo Tian, Yafei Wang, Xiuping Yang
BACKGROUND: Although the technique of single-incision laparoscopic cholecystectomy (SILC) has improved remarkably, problems such as limited exposure and instrument collision persist. We describe a new SILC technique that uses a set of specially-designed needle instruments. METHODS: Fifty-six patients with benign gallbladder disease underwent SILC using the newly-designed needle assembly instruments (NAIs). The NAIs comprise an needle assembly exposing hook for operative field exposure and an needle assembly electrocoagulation hook for dissection...
March 5, 2024: Surgical Innovation
https://read.qxmd.com/read/38443112/use-of-a-fatty-meal-cholecystagogue-protocol-in-hepatobiliary-scintigraphy-for-chronic-functional-gallbladder-disease
#39
JOURNAL ARTICLE
Justin G Peacock, Horace A Hayes, Tylor D Connor
Chronic functional gallbladder disorder, characterized by biliary pain in the absence of structural pathology, poses a diagnostic challenge necessitating reliable cholecystagogues for accurate evaluation. However, recurrent shortages of synthetic cholecystokinin analogs have prompted the exploration of alternative agents. This paper describes the efficacy of Ensure Plus as a viable fatty meal substitute for hepatobiliary scintigraphy in assessing chronic functional gallbladder disorder. Through comparative studies, Ensure Plus demonstrates comparable diagnostic accuracy to cholecystokinin in similar patient populations...
March 5, 2024: Journal of Nuclear Medicine Technology
https://read.qxmd.com/read/38434254/delayed-duodenal-gastric-fistula-resulting-in-persistent-perihepatic-abscesses-as-a-late-complication-of-laparoscopic-cholecystectomy
#40
Phuong Vu, Meelod Daneshvar, Jayakrishna Chintanaboina, Amir Fathi
Since the early 1990's, laparoscopic cholecystectomy has become the gold standard for the treatment of symptomatic gallbladder disease. Although the incidence of postoperative complications is generally lower with this approach, gallbladder perforation represents a serious risk that is among the most common complications of laparoscopic cholecystectomy. The sequalae that can follow iatrogenic perforation have not been well documented and only a few case reports exist in the current literature. In this paper we discuss two case reports of delayed perihepatic abscesses following prior laparoscopic cholecystectomy, ultimately resulting in fistulous tracts...
February 2024: Journal of Surgical Case Reports
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