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https://www.readbyqxmd.com/read/29335862/rules-of-meridians-and-acupoints-selection-in-treatment-of-parkinson-s-disease-based-on-data-mining-techniques
#1
Zhe Li, Ying-Yu Hu, Chun-Ye Zheng, Qiao-Zhen Su, Chang An, Xiao-Dong Luo, Mao-Cai Liu
OBJECTIVE: To help selecting appropriate meridians and acupoints in clinical practice and experimental study for Parkinson's disease (PD), the rules of meridians and acupoints selection of acupuncture and moxibustion were analyzed in domestic and foreign clinical treatment for PD based on data mining techniques. METHODS: Literature about PD treated by acupuncture and moxibustion in China and abroad was searched and selected from China National Knowledge Infrastructure and MEDLINE...
January 15, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29334607/geographical-variations-and-trends-in-major-cancer-incidences-throughout-korea-during-1999-2013
#2
Young-Joo Won, Kyu-Won Jung, Chang-Mo Oh, Eun-Hye Park, Hyun-Joo Kong, Duk Hyoung Lee, Kang Hyun Lee
Purpose: We aimed to describe the temporal trends and district-level geographical variations in cancer incidences throughout Korea during 1999-2013. Materials and Methods: Data were obtained from the Korean National Cancer Incidence Database. We calculated the age-standardized cumulative cancer incidences according to sex and geographical region (metropolitan cities, provinces, and districts) for three 5-year periods (1999-2003, 2004-2008, and 2009-2013). Each quintile interval contained the same number of regions...
January 4, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29333003/histopathological-study-of-gallbladder-carcinoma-and-its-mimics-with-role-of-carcinoembryonic-antigen-immunomarker-in-resolving-diagnostic-difficulties
#3
Santosh Kumar Mondal, Debashish Bhattacharjee, Palash Kumar Mandal, Saumitra Biswas
Background: Gallbladder carcinoma (GBC) sometimes presents with nonspecific signs, without forming a mass, mimicking benign gallbladder (GB) diseases. On the contrary, benign GB diseases may mimic GBC. Material and Methods: We retrospectively reviewed 107 cases over a period of 3 years (May 2012-April 2015), which included 41 review cases and 66 departmental cases. Carcinoembryonic antigen (CEA) immunomarker expression was done. Results: In 27 of the 41 review cases, the diagnoses were benign diseases of GB associated with mild-to-moderate dysplasia of mucosal glands; however, after review in our department, it was found that of these 27 cases, nine cases were actually well-differentiated adenocarcinoma of GB with diffuse CEA expression and were mis diagnosed as benign diseases of GB with dysplasia...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29329599/gallbladder-ascariasis-in-kosovo-focus-on-ultrasound-and-conservative-therapy-a-case-series
#4
Vlora Ismaili-Jaha, Halim Toro, Lidvana Spahiu, Mehmedali Azemi, Teuta Hoxha-Kamberi, Muharrem Avdiu, Shqipe Spahiu-Konjusha, Luan Jaha
BACKGROUND: Ascaris lumbricoides is one of the most common intestinal infections in developing countries, including Kosovo. In contrast to migration to the bile duct, migration of the worm to the gallbladder, due to the narrow and tortuous nature of the cystic duct, is rare. When it does occur, it incites acalculous cholecystitis. CASE PRESENTATIONS: This case series describes a 16-month-old Albanian girl, a 22-month-old Albanian girl, a 4-year-old Albanian girl, and a 10-year-old Albanian boy...
January 13, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29324798/qualitative-metabolomics-profiling-of-serum-and-bile-from-dogs-with-gallbladder-mucocele-formation
#5
Jody L Gookin, Kyle G Mathews, John Cullen, Gabriela Seiler
Mucocele formation is characterized by secretion of abnormally thick mucus by the gallbladder epithelium of dogs that may cause obstruction of the bile duct or rupture of the gallbladder. The disease is increasingly recognized and is associated with a high morbidity and mortality. The cause of gallbladder mucocele formation in dogs is unknown. There is a strong breed predisposition and affected dogs have a high incidence of concurrent endocrinopathy or hyperlipidemia. These observations suggest a significant influence of both genetic and metabolic factors on disease pathogenesis...
2018: PloS One
https://www.readbyqxmd.com/read/29320323/multimodality-imaging-including-dual-energy-ct-in-the-evaluation-of-gallbladder-disease
#6
Lisa Ratanaprasatporn, Jennifer W Uyeda, Jeremy R Wortman, Ian Richardson, Aaron D Sodickson
Imaging of the gallbladder has a key role in the examination of patients with abdominal pain-especially pain localized to the right upper quadrant. Pathologic conditions that affect the gallbladder include cholelithiasis and associated complications such as acute and chronic cholecystitis, choledocholithiasis, gallstone pancreatitis, and cancer. Modalities used to image the gallbladder include ultrasonography (US), computed tomography (CT), magnetic resonance (MR) imaging, and nuclear scintigraphy. US is the primary imaging modality used to evaluate entities suspected of being gallbladder disease, as it is both sensitive and specific for demonstrating gallstones, biliary duct dilatation, and inflammatory features...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29317704/biofilm-formation-protects-salmonella-from-the-antibiotic-ciprofloxacin-in-vitro-and-in-vivo-in-the-mouse-model-of-chronic-carriage
#7
Juan F González, Halley Alberts, Joel Lee, Lauren Doolittle, John S Gunn
Typhoid fever is caused by the human-restricted pathogen Salmonella enterica sv. Typhi. Approximately 5% of people that resolve the disease become chronic carriers, with the gallbladder as the main reservoir of the bacteria. Of these, about 90% present with gallstones, on which Salmonella form biofilms. Because S. Typhi is a human-restricted pathogen, these carriers are the main source of dissemination of the disease; unfortunately, antibiotic treatment has shown to be an ineffective therapy. This is believed to be caused by the inherent antibiotic resistance conferred by Salmonella biofilms growing on gallstones...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29305364/postsurgical-pyoderma-gangrenosum-after-an-autologous-stem-cell-transplantation-for-multiple-myeloma
#8
Maria Cecilia Borges Bittencourt, Marcelo Junqueira Atanazio, Erick Menezes Xavier, Silvia Figueiredo Costa
We report a man who underwent autologous stem cell transplantation (ASCT) for multiple myeloma. Two months after ASCT, he presented with necrotising cholecystitis due to gallbladder stones and was submitted to laparoscopic cholecystectomy. About a week later, he developed progressive skin ulcers at sites where trochanters had been inserted. Progressive enlargement and necrotic aspect of these ulcers took place despite debridement and large spectrum antibiotics. New ulcers developed at the site of enoxaparin injection at the right arm (pathergy phenomenon)...
January 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29295882/chemoradiotherapy-versus-chemotherapy-alone-for-unresected-nonmetastatic-gallbladder-cancer-national-practice-patterns-and-outcomes
#9
Vivek Verma, Swati M Surkar, Eric D Brooks, Charles B Simone, Chi Lin
Purpose: Current guidelines recommend chemotherapy (CT) with or without radiotherapy for unresected nonmetastatic gallbladder cancer (GC), with little consensus. However, several small-volume, single-institution studies have documented the efficacy of local therapy for this population. This is the largest study to date evaluating outcomes of chemoradiotherapy (CRT) versus CT alone in unresected nonmetastatic GC. Methods: The National Cancer Database was queried for primary GC cases (2004-2013) receiving CT alone or CRT...
January 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29286615/epcam-based-flow-cytometric-detection-of-circulating-tumor-cells-in-gallbladder-carcinoma-cases
#10
Namrata Punit Awasthi, Swati Kumari, Azfar Neyaz, Sameer Gupta, Akash Agarwal, Ashish Singhal, Nuzhat Husain
Purpose: Liquid biopsy has entered the arena of cancer diagnostics in the past decade and detection of circulating tumor cells (CTC) is one diagnostic component. CTCs in gallbladder cancer (GBC) have hitherto not been comprehensively analysed. Methods and Results: The current study focused on the diagnostic role of CTCs in 27 cases of treatment-naive GBC and 6 normal controls as well as 6 cases of cholecystitis. An EasySep kit featuring negative immunomagnetic bead separation and flow cytometric detection of EpCAM positive and CD45 negative cells revealed CTCs in 25 of the 27 cases...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29283909/an-update-on-the-pathogenesis-of-cholesterol-gallstone-disease
#11
Agostino Di Ciaula, David Q-H Wang, Piero Portincasa
PURPOSE OF REVIEW: Gallstone disease is a major epidemiologic and economic burden worldwide, and the most frequent form is cholesterol gallstone disease. RECENT FINDINGS: Major pathogenetic factors for cholesterol gallstones include a genetic background, hepatic hypersecretion of cholesterol, and supersaturated bile which give life to precipitating cholesterol crystals that accumulate and grow in a sluggish gallbladder. Additional factors include mucin and inflammatory changes in the gallbladder, slow intestinal motility, increased intestinal absorption of cholesterol, and altered gut microbiota...
December 27, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29249117/patterns-of-initial-failure-after-resection-for-gallbladder-cancer-implications-for-adjuvant-radiotherapy
#12
Tae Gyu Kim
Purpose: This study sought to identify potential candidates for adjuvant radiotherapy and patterns of regional failure in patients who underwent curative-intent surgery for gallbladder cancer. Materials and Methods: Records for 70 patients with gallbladder cancer who underwent curative resection at a single institution between 2000 and 2016 were analysed retrospectively. No patients received adjuvant radiotherapy. Initial patterns of failure were evaluated. Regional recurrence was categorized according to the definitions of lymph node stations suggested by the Japanese Society of Hepato-Biliary-Pancreatic Surgery...
December 20, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29248400/the-risk-of-incidental-gallbladder-cancer-is-negligible-in-macroscopically-normal-cholecystectomy-specimens
#13
Hanna Koppatz, Arno Nordin, Tom Scheinin, Ville Sallinen
BACKGROUND: Cholecystectomy is usually carried out for benign indications. Most perform routine histopathologic examination to detect incidental gallbladder cancer (GBC). METHODS: Cholecystectomies performed at four hospitals in the Helsinki Metropolitan Area during 2010-2012 were analyzed retrospectively. Patients with preoperative suspicion of neoplasia, active malignancy, or in whom cholecystectomy was performed as a secondary procedure were excluded. RESULTS: A total of 2034 cholecystectomies were included...
December 13, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29247966/post-cholecystectomy-syndrome-need-to-redo-laparoscopic-completion-surgery-a-case-report
#14
Ali Zahedian, Sekineh Kamali Ahangar, Yasser Asghari
INTRODUCTION: Cholecystectomy is the standard treatment for symptomatic gallbladder stone disease. However, symptoms such as abdominal pain and dyspepsia may persist even after surgery, if the gallbladder is incompletely removed known as postcholecystectomy syndrome. CASE PRESENTATION: A 55-year-old man with a history of open cholecystectomy presented with a complaint of recurrent pain on his upper abdomen. Abdominal ultrasonography and magnetic resonance cholangiopancreatography revealed a cystic structure in the gallbladder fossa, with a filling defect at the midpoint of the cystic duct, suggesting a retained stone in the cystic duct and residual gallbladder...
December 9, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29238914/clinical-and-genetic-implications-of-dna-mismatch-repair-deficiency-in-biliary-tract-cancers-associated-with-lynch-syndrome
#15
Jordan M Cloyd, Yun Shin Chun, Naruhiko Ikoma, Jean Nicolas Vauthey, Tlhomas A Aloia, Amanda Cuddy, Miguel A Rodriguez-Bigas, Y Nancy You
PURPOSE: Patients with Lynch syndrome (LS) have a significantly elevated lifetime risk of developing biliary tract cancers (BTCs) compared to the general population. However, few studies have characterized the clinical characteristics, genetic features, or long-term outcomes of mismatch-repair deficient (dMMR) cholangiocarcinomas associated with LS. METHODS: A retrospective review of a prospectively maintained Familial High-Risk GI Cancer Clinic database identified all patients with BTCs evaluated from 2006 to 2016 who carried germline mutations in MLH1, MSH2, MSH6, or PMS2...
December 14, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29234972/staging-treatment-and-future-approaches-of-gallbladder-carcinoma
#16
REVIEW
Sanjeev Kumar Shukla, Govind Singh, K S Shahi, Bhuvan, Prabhat Pant
BACKGROUND: Gallbladder cancer is the most common malignant cancer of the bile ducts and third most common gastrointestinal malignant in the world for public health. Its relatively low incidence and confused symptoms result in advanced disease at the time of presentation, contributing to poor prognosis and reduced survival associated with this disease. The main function of the gallbladder is to store excreted bile acids from the liver in preparation for a meal. Its main risk factor is prolonged exposure to biliary calculations, although bacterial infections and other inflammatory conditions are associated...
December 12, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29234813/hormone-therapy-for-the-primary-prevention-of-chronic-conditions-in-postmenopausal-women-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#17
REVIEW
Gerald Gartlehner, Sheila V Patel, Cynthia Feltner, Rachel Palmieri Weber, Rachel Long, Kelly Mullican, Erin Boland, Linda Lux, Meera Viswanathan
Importance: Postmenopausal status coincides with increased risks for chronic conditions such as heart disease, osteoporosis, cognitive impairment, or some types of cancers. Previously, hormone therapy was used for the primary prevention of these chronic conditions. Objective: To update evidence for the US Preventive Services Task Force on the benefits and harms of hormone therapy in reducing risks for chronic conditions. Data Sources: MEDLINE, Cochrane Library, EMBASE, and trial registries from June 1, 2011, through August 1, 2016...
December 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29231557/-discussion-on-rules-of-acupoint-selection-for-vascular-dementia
#18
Shuai Li, Jie Tan, Hong Zhang, Guilan Huang, Duoxi Deng, Quanrui Jiang
OBJECTIVE: The clinical research literature regarding acupuncture treatment for vascular dementia was reviewed and analyzed to provide the references for clinical selection and compatibility of acupoints. METHODS: With computer and manual retrieval method, the clinical literature regarding acupuncture treatment for vascular dementia in recent 10 years was collected. The acupoint type, meridian and use frequency were analyzed. RESULTS: Totally 38 articles of acupuncture treatment for vascular dementia were screened; the most selected meridians were the governor vessel, gallbladder meridian, stomach meridian and spleen meridian; the main acupoints with frequency of more than 5 times were Baihui (GV 20), Sishencong (EX-HN 1), Shenting (GV 24), Fengchi (SP 40) and Shuigou (GV 26); the matching acupoints with frequency of more than 5 times were Fenglong (ST 40), Zusanli (ST 36), Taichong (LR 3), Taixi (KI 3), Sanyinjiao (SP 6), Xuehai (SP 10), Zhongwan (CV 12), Neiguan (PC 6), Fengchi (GB 20)...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29225328/gallbladder-hypoplasia-a-congenital-abnormality-of-the-gallbladder-a-case-report
#19
Christophoros S Kosmidis, Georgios D Koimtzis, Maria S Kosmidou, Fotini Ieridou, Triantafyllia Koletsa, Katerina T Zarampouka, Eleni Georgakoudi, Isaac Kesisoglou
BACKGROUND There are different variations in the anatomy of the gallbladder. Congenital abnormalities of the gallbladder such as agenesis and hypoplasia are rare conditions and difficult to diagnose with imaging studies. Patients are usually asymptomatic or have symptoms that mimic gallstone disease. The diagnosis is often made intraoperatively and is established by histopathological examination. CASE REPORT We report a case of a 62-year-old male who had cholelithiasis symptoms and was falsely diagnosed with gallstone disease by abdominal ultrasound scan...
December 11, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29221432/sex-and-ethnic-racial-specific-risk-factors-for-gallbladder-disease
#20
Jane C Figueiredo, Christopher Haiman, Jacqueline Porcel, James Buxbaum, Daniel Stram, Neal Tambe, Wendy Cozen, Lynne Wilkens, Loic Le Marchand, Veronica Wendy Setiawan
BACKGROUND: Gallbladder disease (GBD) is a highly prevalent condition; however, little is known about potential differences in risk factors by sex and ethnicity/race. Our aim was to evaluate dietary, reproductive and obesity-related factors and GBD in multiethnic populations. METHODS: We performed a prospective analysis from the Multiethnic Cohort study who self-identified as non-Hispanic White (n = 32,103), African American (n = 30,209), Japanese (n = 35,987), Native Hawaiian (n = 6942) and Latino (n = 39,168)...
December 8, 2017: BMC Gastroenterology
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