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Gallbladder disease

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https://www.readbyqxmd.com/read/29138340/phase-i-study-of-chimeric-antigen-receptor-modified-t-cells-in-patients-with-egfr-positive-advanced-biliary-tract-cancers
#1
Yelei Guo, Kai-Chao Feng, Yang Liu, Zhiqiang Wu, Hanren Dai, Qing-Ming Yang, Yao Wang, Hejin Jia, Weidong Han
PURPOSE: This study is an expanded and parallel clinical trial of epidermal growth factor receptor (EGFR)-specific chimeric antigen receptor-engineered autologous T (CART) cell immunotherapy (NCT01869166) to assess the safety and activity of CART-EGFR cell therapy in EGFR-positive advanced unresectable, relapsed/metastatic biliary tract cancers (BTCs). PATIENTS AND METHODS: Patients with EGFR-positive (>50%) advanced unresectable, relapsed/metastatic BTCs were enrolled...
November 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29134969/the-prevalence-and-impact-of-overlapping-rome-iv-diagnosed-functional-gastrointestinal-disorders-on-somatization-quality-of-life-and-healthcare-utilization-a-cross-sectional-general-population-study-in-three-countries
#2
Imran Aziz, Olafur S Palsson, Hans Törnblom, Ami D Sperber, William E Whitehead, Magnus Simrén
OBJECTIVES: The population prevalence of Rome IV-diagnosed functional gastrointestinal disorders (FGIDs) and their cumulative effect on health impairment is unknown. METHODS: An internet-based cross-sectional health survey was completed by 5,931 of 6,300 general population adults from three English-speaking countries (2100 each from USA, Canada, and UK). Quota-based sampling was used to generate demographically balanced and population representative samples with regards to age, sex, and education level...
November 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29127962/minimally-invasive-hepatobiliary-surgery
#3
REVIEW
Omid Madadi-Sanjani, Claus Petersen, Benno Ure
Comparative studies and large-scale case series that confirm the advantages of laparoscopy in children with hepatobiliary diseases are scarce, and the use of laparoscopy remains a matter of debate. This article reviews the current literature on the role of laparoscopic and robotic surgery in pediatric patients with choledochal cyst, biliary atresia, gallbladder diseases, and hepatobiliary malignancies. Studies were identified through a search of the MEDLINE database. Laparoscopy may be beneficial for resection of choledochal cyst and cholecystectomy...
December 2017: Clinics in Perinatology
https://www.readbyqxmd.com/read/29119003/novel-associations-of-bile-acid-diarrhoea-with-fatty-liver-disease-and-gallstones-a-cohort-retrospective-analysis
#4
Richard N Appleby, Jonathan D Nolan, Ian M Johnston, Sanjeev S Pattni, Jessica Fox, Julian Rf Walters
Background: Bile acid diarrhoea (BAD) is a common cause of chronic diarrhoea with a population prevalence of primary BAD around 1%. Previous studies have identified associations with low levels of the ileal hormone fibroblast growth factor 19 (FGF19), obesity and hypertriglyceridaemia. The aim of this study was to identify further associations of BAD. Methods: A cohort of patients with chronic diarrhoea who underwent (75)selenohomocholic acid taurate (SeHCAT) testing for BAD was further analysed retrospectively...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29117670/association-between-dietary-intake-and-postlaparoscopic-cholecystectomic-symptoms-in-patients-with-gallbladder-disease
#5
Yongju Shin, Dongho Choi, Kyeong Geun Lee, Ho Soon Choi, Yongsoon Park
Background/Aims: After cholecystectomy, patients have reported postcholecystectomic syndromes such as abdominal symptoms, dyspepsia, and diarrhea, which suggest a relationship between cholecystectomic symptoms and diet, although the details of this association remain unclear. The present study investigated the hypothesis that dietary intake of nutrients and foods was significantly associated with postcholecystectomic syndromes. Methods: Gallstone patients (n = 59) who underwent laparoscopic cholecystectomy were enrolled, and dietary intake and clinical parameters were assessed immediately postcholecystectomy and 3 months later...
November 10, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29109099/targeted-gene-sequencing-of-gallbladder-carcinoma-identifies-high-impact-somatic-and-rare-germline-mutations
#6
REVIEW
Saurabh Yadav, Navonil DE Sarkar, Niraj Kumari, Narendra Krishnani, Ashok Kumar, Balraj Mittal
BACKGROUND: Gallbladder carcinoma (GBC) is a subtype of biliary tract malignancy with poor prognosis and high fatality rate. The present study was designed to uncover somatic and rare germline mutations in GBC to reveal the disease biology and understand the clinical importance of mutation profile in terms of prognostics and actionability. MATERIALS AND METHODS: We performed ultra-deep sequencing across 409 cancer-related genes in 11 GBC patients of North-Indian descent...
November 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/29104833/the-effervescent-gallbladder-an-emergency-medicine-bedside-ultrasound-diagnosis-of-emphysematous-cholecystitis
#7
Brian B Wexler, Nova L Panebianco
Emphysematous cholecystitis (EC) is a distinct clinical disease that carries a high rate of morbidity and mortality. Maintaining a high index of suspicion, especially in the right patient population, combined with emergency bedside ultrasound can lead to rapid diagnosis and initiation of treatment for this life threatening condition.
July 27, 2017: Curēus
https://www.readbyqxmd.com/read/29096338/liver-abscess-and-sepsis-caused-by-clostridium-perfringens-and-klebsiella-oxytoca
#8
Christoph Paasch, Stefan Wilczek, Martin W Strik
INTRODUCTION: Clostridium (C) perfringens and Klebsiella (K) oxytoca are pathogenous human bacteria. Due to the production of several toxins C. perfringens is virulent by causing i.a. the necrotizing fasciitis, gas gangrene and hepatic abscess. K. oxytoca mostly causes infections of the respiratory and gastrointestinal tract. PRESENTATION OF CASE: We are presenting the case of a male patient at the age of 64, who suffered from nausea and progressive pain in the right upper abdomen...
October 26, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29079926/adjuvant-chemoradiotherapy-is-associated-with-improved-survival-for-patients-with-resected-gallbladder-carcinoma-a-systematic-review-and-meta-analysis
#9
Byoung Hyuck Kim, Jeanny Kwon, Eui Kyu Chie, Kyubo Kim, Young Hoon Kim, Dong Wan Seo, Amol K Narang, Joseph M Herman
BACKGROUND: The impact of adjuvant radiotherapy (ART) on survival from gallbladder carcinoma (GBC) remains underexplored, with conflicting results reported. A systematic review and meta-analysis was performed to clarify the impact of ART in GBC. METHODS: A systematic literature search of several databases was performed following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, from inception to August 2016. Studies that reported survival outcomes for patients with or without ART after curative surgery were included...
October 27, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29079901/diabetes-and-the-pancreatobiliary-diseases
#10
REVIEW
Muhammad Shafqet, Kaveh Sharzehi
PURPOSE OF REVIEW: The emphasis of this review article is to bring to the forefront the spectrum of pancreatobiliary disorders and their association with diabetes. We hope to systematically discuss the link between diabetes and disorders of the pancreas including acute and chronic pancreatitis, as well as pancreatic cancer. We also hope to review and highlight the literature with respect to other cancers of the biliary tree including gallbladder and cholangiocarcinoma. Lastly, we discuss diabetes and biliary dyskinesia...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29078901/hispanic-ethnicity-and-complication-profile-following-laparoscopic-and-open-cholecystectomy
#11
Hailey C Budnick, Isaac L Lee, Stacey A Milan
BACKGROUND: Hispanic ethnicity is associated with increased incidence of gallbladder disease. Additionally, ethnicity has been shown to be an outcome determinant in several conditions and procedures but has never been studied as a potential determinant of morbidity or mortality after laparoscopic or open cholecystectomy. METHODS: Using the American College of Surgeons National Surgical Quality Improvement Program database, patients who underwent cholecystectomy and related procedures were studied in Hispanic and non-Hispanic cohorts...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29069888/tumor-marker-kinetics-as-prognosticators-in-patients-with-unresectable-gallbladder-adenocarcinoma-undergoing-palliative-chemotherapy
#12
Jae Woo Lee, Yong-Tae Kim, Sang Hyub Lee, Jun Hyuk Son, Jin Woo Kang, Ji Kon Ryu, Dong Kee Jang, Woo Hyun Paik, Ban Seok Lee
Background/Aims: To determine the prognostic value of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 in gallbladder cancer (GBC) during palliative chemotherapy. Methods: One hundred and twenty-three patients with pathologically confirmed unresectable GBC were included. Differences in serum CEA and CA 19-9 levels before and after chemotherapy were measured. Receiver operating characteristic curve analysis, Kaplan-Meier analyses of CEA, CA 19-9, and combined changes were performed to assess the optimal cutoff values and survival rates...
October 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29067947/laparoscopic-management-of-massive-intraperitoneal-haemorrhage-caused-by-an-acute-gallbladder-perforation
#13
Seokyoun Lee, Jungnam Kwon, Keunyoung Kim
Laparoscopic cholecystectomy is the gold standard for managing the treatment of patients with symptomatic gallstone disease. Certain patients with acute cholecystitis will develop gallbladder perforation (GP). Furthermore, massive intraperitoneal haemorrhage following perforation is a rare complication. The high morbidity and mortality rates associated with this condition are due to delays in the diagnosis and treatment since signs and symptoms of perforation do not differ significantly from those of uncomplicated cholecystitis...
October 23, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29066119/concurrent-chemoradiotherapy-in-curatively-resected-gallbladder-carcinoma-a-propensity-score-matched-analysis
#14
Benxing Gu, Liwen Qian, Hong Yu, Jianbin Hu, Qi Wang, Jingjing Shan, Liming Shi, Hai Liu, Qichu Yang, Xiao Liang, Xiujun Cai, Xiaonan Sun
PURPOSE: To compare overall survival (OS) between patients receiving radical resection followed by concurrent chemoradiotherapy (S+CCRT) and patients receiving radical resection only (S) for advanced resectable gallbladder carcinoma (GBC). METHODS AND MATERIALS: Ninety-four GBC patients with stage pT2-4, N0-1, and M0 consented to inclusion in a clinical database from June 2003 to July 2013. Patients who received S+CCRT were matched by propensity score with those who received S through nearest-neighbor matching, with a caliper width of 0...
September 20, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29063057/clinical-epidemiological-survey-of-gallbladder-carcinoma-in-northwestern-china-2009-2013-2379-cases-in-17-centers
#15
Hao-Xin Shen, Hu-Wei Song, Xin-Jian Xu, Zuo-Yi Jiao, Zhen-Yu Ti, Zhao-Yu Li, Bin Ren, Chen Chen, Li Ma, Ya-Ling Zhao, Guan-Jun Zhang, Jian-Cang Ma, Xi-Lin Geng, Xiao-Di Zhang, Jing-Sen Shi, Lin Wang, Zhi-Min Geng
OBJECTIVE: To analyze the clinical epidemiological characteristics of patients with gallbladder carcinoma recruited from 17 hospitals in five northwestern provinces of China (Shaanxi Province, Gansu Province, Qinghai Province, Ningxia Hui Autonomous Region, and Xinjiang Uygur Autonomous Region) from 2009 to 2013, and to summarize the clinical diagnosis and treatment data of gallbladder carcinoma. METHODS: Clinical information of 2379 patients with gallbladder carcinoma from 17 hospitals in five northwestern provinces of China was retrospectively collected and analyzed using the "Questionnaire for Gallbladder Carcinoma Patients in Northwestern Area of China...
March 25, 2017: Chronic Dis Transl Med
https://www.readbyqxmd.com/read/29057726/-treatment-for-acute-cholecystitis
#16
C S Loozen, D Boerma, H C van Santvoort
- This article provides an update on the current state of treatment in respect of acute cholecystitis. Several aspects are addressed such as the timing of, and approach to, cholecystectomy, the benefits and disadvantages of percutaneous gallbladder drainage, conservative treatment and the usefulness of antibiotic prophylaxis.- Early cholecystectomy is superior to delayed cholecystectomy as this is associated with fewer wound infections, shorter hospital stay, lower costs and greater patient satisfaction.- Radiological percutaneous drainage in the acute phase of cholecystitis is a procedure with high short-term success rates, but it appears to be associated with high rates of recurrent gallstone-related disease...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29052825/managing-endoscopic-retrograde-cholangiopancreatography-related-complications-in-patients-referred-to-the-surgical-emergency-unit
#17
Osman Şimşek, Arife Şimşek, Sefa Ergun, Mehmet Velidedeoğlu, Kaya Sarıbeyoğlu, Salih Pekmezci
BACKGROUND: The goal of this study was to present our experience in the management of endoscopic retrograde cholangiopancreatography-related complications in patients referred to our surgical emergency unit by various endoscopy centers. METHODS: A retrospective investigation was conducted on the records of the 54 patients who were referred to our surgical emergency unit between October 2005 and January 2014 due to endoscopic retrograde cholangiopancreatography-related complications...
September 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29051399/the-impact-of-gallbladder-retrieval-from-an-epigastric-vs-umbilical-port-on-trocar-site-complications-a-prospective-randomized-study
#18
Cemal Kaya, Emre Bozkurt, Pinar Yazici
AIM: Port-site infection and hernias are among the most of the complications following laparoscopic cholecystectomy (LC). Although surgical technique of LC is described to obtain critical view of safety, there is still no consensus on ideal portsite for gallbladder retrieval. In this comparative study, we aimed to investigate the effects of gallbladder retrieval site on postoperative port site complications following LC. MATERIAL AND METHODS: In this prospective randomized study, 120 patients underwent LC for symptomatic gallbladder disease...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29046787/relapsed-and-unresectable-inflammatory-myofibroblastic-tumor-responded-to-chemotherapy-a-case-report-and-review-of-the-literature
#19
Yasuhiro Maruyama, Toshirou Fukushima, Daisuke Gomi, Takashi Kobayashi, Nodoka Sekiguchi, Akiyuki Sakamoto, Shigeru Sasaki, Keiko Mamiya, Tomonobu Koizumi
A 63-year-old female patient who had undergone cholecystectomy for inflammatory myofibroblastic tumor (IMT) in the gallbladder was referred to our hospital. The patient's disease relapsed, involving the pancreas, and was diagnosed as inoperable IMT 13 months after the cholecystectomy. The patient failed to respond to steroid and non-steroidal anti-inflammatory drug therapy, but subsequently exhibited a good response to vinorelbine and methotrexate combination chemotherapy. Little information is currently available on the efficacy of chemotherapy for adult-onset IMT...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29043711/the-many-guises-of-endometriosis-giant-abdominal-wall-endometriosis-masquerading-as-an-incisional-hernia
#20
Chiara Petrosellini, Sala Abdalla, Tayo Oke
Endometriosis is defined by the presence of ectopic endometrial tissue outside the uterine cavity. Although it is a leading cause of chronic pelvic pain and infertility, its clinical presentation can vary, resulting in diagnostic and therapeutic challenges. Extrapelvic endometriosis is particularly difficult to diagnose owing to its ability to mimic other conditions. Endometrial tissue in a surgical scar is uncommon and often misdiagnosed as a granuloma, abscess, or malignancy. Cyclical hemorrhagic ascites due to peritoneal endometriosis is exceptionally rare...
January 2018: International Journal of Fertility & Sterility
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