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Gallbladder disease

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https://www.readbyqxmd.com/read/29791592/pathogenesis-of-gallbladder-adenomyomatosis-and-its-relationship-with-early-stage-gallbladder-carcinoma-an-overview
#1
Liwei Pang, Yan Zhang, Yuwen Wang, Jing Kong
The exact pathogenesis of gallbladder adenomyomatosis is still lacking and some controversies over its diagnosis and treatment exist. Originally recognized as a precancerous lesion, adenomyomatosis is currently recognized by recent studies as a benign alteration of the gallbladder that is often associated with cholecystitis and cholecystolithiasis. Gallbladder carcinoma is an extremely malignant disease with a 5-year survival rate of less than 5%. Therefore, it is important to diagnose, differentiate, and confirm the relationship between adenomyomatosis and early-stage gallbladder carcinoma...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29788702/the-prevalence-of-gallstone-disease-is-significantly-lower-in-natives-than-in-migrants-of-jeju-island
#2
Oh-Sung Kwon, Young-Kyu Kim, Kyu Hee Her
BACKGROUND: The eating habits of Jeju Island natives are quite different from those of the mainland people because of geographic isolation. Diet is a main factor affecting gallstone disease. We investigated the prevalence of gallstone disease in both Jeju Island natives and migrants and studied the risk factors affecting gallstone disease in the Jeju Island people. METHODS: A total of 20,763 subjects who underwent medical checkups at the Health Promotion Center of Jeju National University Hospital in Korea from January 2003 to December 2015 were enrolled in the study...
May 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29783219/-clinical-and-laboratory-features-of-cholelithiasis-in-patients-with-type-2-diabetes-by-gender
#3
Natalya I Dyakiv-Koreiba
OBJECTIVE: Introduction: Today, diabetes is considered a factor that provokes the development of bile duct disease. Cholelithiasis is associated with such risk factors as aging, high body mass index, female sex, genetic predisposition, alcohol abuse, high concentration of triglycerides and cholesterol, low density lipoprotein in blood plasma The aim of the work is to analyze the clinical and laboratory features of the pathology of the gall bladder in patients with type 2 diabetes, depending on the sex...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29773765/a-comprehensive-review-on-primary-gallbladder-tuberculosis
#4
Ashish Gupta, Amit Gupta, Rohik Anjum, Saumya Agrawal, Dhiraj Mallik
Tuberculosis (TB) is an infectious disease that can affect any organ system of the body. Abdominal TB can be gastrointestinal, lymph nodal, visceral or peritoneal. The gallbladder (GB) is rarely involved in abdominal TB as a primary organ. Extensive research literature on gallbladder TB is limited to case reports. There has been no review on this rare abdominal pathology. GB tuberculosis is a difficult diagnosis preoperatively. It is a rare differential among the more common gallbladder pathologies such as cholelithiasis, or a gallbladder malignancy...
April 30, 2018: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29770794/ursodeoxycholic-acid-protects-interstitial-cajal-like-cells-in-the-gallbladder-from-undergoing-apoptosis-by-inhibiting-tnf-%C3%AE-expression
#5
Jiang-Fan Wan, Shi-Feng Chu, Xin Zhou, Yue-Ting Li, Wen-Bin He, Feng Tan, Piao Luo, Qi-di Ai, Qi Wang, Nai-Hong Chen
Hypomotility is a common symptom of gallstone disease, which is accompanied by a loss of interstitial Cajal-like cells (ICLCs) in the gallbladder. Ursodeoxycholic acid (UDCA) is widely used in treating gallstone disease, and has shown anti-apoptotic and anti-inflammatory effects apart from its ability to dissolve gallstones. In this study, we investigated the anti-apoptotic and anti-inflammatory effects of UDCA on ICLCs in guinea pigs with gallstones. Guinea pigs were fed a high-cholesterol diet for 8 weeks to induce the formation of gallstones...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29761515/association-of-perioperative-transfusion-with-survival-and-recurrence-after-resection-of-gallbladder-cancer-a-10-institution-study-from-the-us-extrahepatic-biliary-malignancy-consortium
#6
Alexandra G Lopez-Aguiar, Cecilia G Ethun, Mia R McInnis, Timothy M Pawlik, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley A Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza W Beal, Ioannis Hatzaras, Rivfka Shenoy, Kenneth Cardona, Shishir K Maithel
BACKGROUND AND OBJECTIVES: Perioperative blood transfusion is associated with poor outcomes in several malignancies. Its effect in gallbladder cancer (GBC) is unknown. METHODS: All patients with GBC who underwent curative-intent resection at 10-institutions from 2000 to 2015 were included. The effect of blood transfusion on overall survival (OS) and recurrence-free (RFS) was evaluated. RESULTS: Of 262 patients with curative-intent resection for GBC, 61 patients (23%) received blood transfusions...
May 14, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29758389/gallbladder-perforation-into-the-greater-omentum-following-sleeve-gastrectomy-a-case-report-study
#7
Suhaib J S Ahmad, Sherif M Hakky, Douglas McWhinnie, Claire J Stocker, Peter Thomas, Sami Ahmad
INTRODUCTION: Obesity is considered a major risk factor for gallstone formation and is important due to its increasing prevalence worldwide. Many studies have reported an increased incidence of gallstone formation following bariatric surgery. This report documents a rare case of a complicated cholecystitis following sleeve gastrectomy and describes our management of the case and the management options for gallbladder disease in bariatric patients. PRESENTATION OF CASE: A 60-year-old male was diagnosed with asymptomatic cholelithiasis at the time of sleeve gastrectomy for obesity treatment...
May 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29757718/us-of-right-upper-quadrant-pain-in-the-emergency-department-diagnosing-beyond-gallbladder-and-biliary-disease
#8
Gayatri Joshi, Kevin A Crawford, Tarek N Hanna, Keith D Herr, Nirvikar Dahiya, Christine O Menias
Acute cholecystitis is the most common diagnosable cause for right upper quadrant abdominal (RUQ) pain in patients who present to the emergency department (ED). However, over one-third of patients initially thought to have acute cholecystitis actually have RUQ pain attributable to other causes. Ultrasonography (US) is the primary imaging modality of choice for initial imaging assessment and serves as a fast, cost-effective, and dynamic modality to provide a definitive diagnosis or a considerably narrowed list of differential possibilities...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29755774/racial-ethnic-disparities-in-gallbladder-cancer-receipt-of-treatments
#9
Veeravich Jaruvongvanich, Buravej Assavapongpaiboon, Linda Wong
Background: Gallbladder cancer is a rare malignancy, yet it has a dismal prognosis. Overall survival has improved in all races/ethnicities except Hispanics and blacks. Despite improvements in gallbladder cancer management, it is not clear whether racial/ethnic disparities in stage at diagnosis and treatments exist that could potentially be the source of survival disparities. The purpose of this study was to examine race/ethnicity-specific trends in the stage of disease and receipt of treatments among adult gallbladder cancer patients in the US...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29753389/prophylactic-cholecystectomy-in-short-bowel-syndrome-is-it-being-utilized
#10
Jon S Thompson, David F Mercer, Luciano M Vargas, Wendy J Grant, Fedja A Rochling, Alan N Langnas
INTRODUCTION: Cholelithiasis is common in patients with short bowel syndrome (SBS). Prophylactic cholecystectomy (PC) of the non-diseased gallbladder has been recommended in SBS patients when laparotomy is being undertaken for other reasons. Our aim was to determine if PC is being utilized. METHODS: 500 adults with SBS were seen over a 25 year period. 215 undergoing cholecystectomy prior to SBS were excluded, leaving 285 patients for evaluation. RESULTS: 151 (53%) SBS patients underwent a subsequent laparotomy...
April 27, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29751790/obliterative-cholangiopathy-in-acquired-cystic-biliary-atresia-type-iii-after-cyst-perforation-a-case-report
#11
Tsugumichi Koshinaga, Kensuke Ohashi, Kakou Ono, Hide Kaneda, Takeshi Furuya
BACKGROUND: In biliary atresia, the disease process of obliterative cholangiopathy may begin in the perinatal period; however, no chronological evidence exists on how the cholangiopathy progresses to biliary obliteration. This is the first acquired case with the final diagnosis of type III cystic biliary atresia with an extrahepatic biliary cyst which showed the progression of obliterative cholangiopathy in chronological order after birth. CASE PRESENTATION: An 81-day-old girl presented with acute abdominal distress due to bilious peritonitis caused by biliary cyst perforation, for which she underwent emergency biliary drainage...
May 11, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29740203/olfactomedin-4-in-digestive-diseases-a-mini-review
#12
REVIEW
Xin-Yu Wang, Sheng-Hui Chen, Ya-Nan Zhang, Cheng-Fu Xu
Olfactomedin-4 (OLFM4, GW112, hGC-1) is a glycoprotein belonging to the olfactomedin family. The expression of OLFM4 is strong in the small intestine, colon and prostate, and moderate in the stomach and bone marrow. Previous studies have revealed that OLFM4 is closely associated with many digestive diseases. Up-regulation of OLFM4 has been detected in the Helicobacter pylori ( H. pylori )-infected gastric mucosa, inflammatory bowel disease tissue and gastrointestinal malignancies, including gastric cancer, colorectal cancer, pancreatic cancer and gallbladder cancer...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29729773/surgical-outcomes-in-alagille-syndrome-and-pfic-a-single-institution-s-20-year-experience
#13
Celia D Flores, Yangyang R Yu, Tamir A Miloh, John Goss, Mary L Brandt
BACKGROUND: Alagille Syndrome (AGS) and Progressive Familial Intrahepatic Cholestasis (PFIC) are rare pediatric biliary disorders that lead to progressive liver disease. This study reviews our experience with the surgical management of these disorders over the last 20years. METHODS: We retrospectively reviewed the records of children diagnosed with AGS or PFIC from January 1996 to December 2016. Data collected included demographics, surgical intervention (liver transplant or biliary diversion), and complications...
May 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29728459/abcg5-and-abcg8-more-than-a-defense-against-xenosterols
#14
Shailendra B Patel, Gregory Graf, Ryan Temel
The elucidation of the molecular basis of the rare disease Sitosterolemia has revolutionized our mechanistic understanding of how dietary sterols are excreted and how cholesterol is eliminated from the body. Two proteins ABCG5 and ABCG8, encoded by the Sitosterolemia locus, work as obligate dimers to pump sterols out of hepatocytes and enterocytes. ABCG5/ABCG8 are key in regulating whole-body sterol trafficking, by eliminating sterols via the biliary tree, as well as the intestinal tract. Importantly, these transporters keep xenosterols from accumulating in the body...
May 4, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29718843/predicting-the-risk-for-colorectal-cancer-with-personal-characteristics-and-fecal-immunochemical-test
#15
Wen Li, Li-Zhong Zhao, Dong-Wang Ma, De-Zheng Wang, Lei Shi, Hong-Lei Wang, Mo Dong, Shu-Yi Zhang, Lei Cao, Wei-Hua Zhang, Xi-Peng Zhang, Qing-Huai Zhang, Lin Yu, Hai Qin, Xi-Mo Wang, Sam Li-Sheng Chen
We aimed to predict colorectal cancer (CRC) based on the demographic features and clinical correlates of personal symptoms and signs from Tianjin community-based CRC screening data.A total of 891,199 residents who were aged 60 to 74 and were screened in 2012 were enrolled. The Lasso logistic regression model was used to identify the predictors for CRC. Predictive validity was assessed by the receiver operating characteristic (ROC) curve. Bootstrapping method was also performed to validate this prediction model...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29714811/gallbladder-carcinoma-an-analysis-of-the-national-cancer-data-base-to-examine-hispanic-influence
#16
Chrissy Liu, Nicholas G Berger, Lisa Rein, Sergey Tarima, Callisia Clarke, Harveshp Mogal, Kathleen K Christians, Susan Tsai, T Clark Gamblin
BACKGROUND: Gallbladder cancer (GBC) is a lethal disease with high incidence among Hispanics. Overall survival (OS) among races/ethnicities has not been described using the most recent National Cancer Database. This study hypothesized that prognosis is worse for Hispanics compared to similar non-Hispanic populations. METHODS: Patients with GBC were identified from the National Cancer Database and categorized as White, Black, Hispanic, and Other. Descriptive statistics, OS, and Cox regression were examined...
May 1, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29708270/acute-acalculous-cholecystitis-in-hospitalized-patients-with-hematologic-malignancies-and-prognostic-importance-of-gallbladder-ultrasound-findings
#17
Rajesh Thampy, Ahmad Khan, Islam H Zaki, Wei Wei, Brinda Rao Korivi, Greg Staerkel, Tharakeswara K Bathala
OBJECTIVES: Patients with hematologic malignancies, especially those with acute disease or those receiving intense chemotherapy, are known to develop acute acalculous cholecystitis (AAC). The aim of this study was to evaluate the diagnostic and prognostic value of the established ultrasound (US) diagnostic criteria for AAC in patients with acute hematologic malignancies who were clinically suspected to have AAC. METHODS: We retrospectively studied the US findings of the gallbladder in patients with hematologic malignancies and correlated these findings with the duration of clinical symptoms, complications, and gallbladder-specific mortality...
April 30, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29707074/hepatobiliary-manifestations-and-complications-in-inflammatory-bowel-disease-a-review
#18
REVIEW
Fotios S Fousekis, Vasileios I Theopistos, Konstantinos H Katsanos, Epameinondas V Tsianos, Dimitrios K Christodoulou
Liver and biliary track diseases are common extraintestinal manifestations of inflammatory bowel disease (IBD), reported both in Crohn's disease and ulcerative colitis, and may occur at any time during the natural course of the disease. Their etiology is mainly related to pathophysiological changes induced by IBD, and secondary, due to drugs used in IBD. Fatty liver is considered as the most frequent hepatobiliary manifestation in IBD, while primary sclerosing cholangitis (PSC) is the most correlated hepatobiliary disorder and is more prevalent in patients with ulcerative colitis...
April 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29706425/outcome-of-neoadjuvant-chemotherapy-in-locally-advanced-borderline-resectable-gallbladder-cancer-the-need-to-define-indications
#19
Vikram A Chaudhari, Vikas Ostwal, Shraddha Patkar, Arvind Sahu, Anup Toshniwal, Anant Ramaswamy, Nitin S Shetty, Shailesh V Shrikhande, Mahesh Goel
BACKGROUND: Studies evaluating neo-adjuvant chemotherapy (NACT) exclusively in gallbladder cancer (GBC) are few and there are no randomized trials on the subject. Locally advanced GBC and indications for NACT in GBC are not yet clearly defined. METHODS: We analysed 160 consecutive GBC patients who received NACT based on clinico-radiologic criteria suggesting high-risk disease (TMH Criteria) from January 2010 to February 2016. RESULTS: On initial assessment, 140 (87...
April 26, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29699698/is-functional-gallbladder-disease-truly-increasing-results-from-the-rochester-epidemiology-project
#20
Mohamed O Abdelhamid, Cornelius A Thiels, Juliane Bingener
INTRODUCTION: Reports from US administrative databases showed an increase in cholecystectomy rate for functional gallbladder disorder (FGBD), a disease is not well recognized elsewhere. We aimed to identify the incidence and cholecystectomy rate for FGBD in an epidemiologically well-defined and prospectively studied population and compare results to published data. METHODS: After IRB approval, we extracted data from the NIH funded Rochester Epidemiology Project...
April 17, 2018: American Journal of Surgery
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