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Acute exacerbations of COPD

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https://www.readbyqxmd.com/read/28526656/effects-of-pulmonary-rehabilitation-on-exacerbation-number-and-severity-in-people-with-copd-an-historical-cohort-study-using-electronic-health-records
#1
Elizabeth Moore, Roger Newson, Miland Joshi, Thomas Palmer, Kieran J Rothnie, Sally Singh, Azeem Majeed, Michael Soljak, Jennifer K Quint
BACKGROUND: In previous systematic reviews, predominantly of randomised controlled trials, pulmonary rehabilitation (PR) has been shown to reduce hospital admissions for acute exacerbations of COPD (AECOPD). However, findings have been less consistent for cohort studies. We aimed to compare rates of hospitalized and general practice (GP) treated AECOPD before and after PR. METHODS: Using anonymised data from the Clinical Practice Research Datalink and Hospital Episode Statistics, hospital admissions and GP visits for AECOPD were compared one year before and after PR in patients referred for PR...
May 16, 2017: Chest
https://www.readbyqxmd.com/read/28514275/acute-exacerbation-of-copd-diagnosis-and-management
#2
Jane S Kaufman
No abstract text is available yet for this article.
June 16, 2017: Nurse Practitioner
https://www.readbyqxmd.com/read/28513453/chronic-obstructive-pulmonary-disease
#3
REVIEW
Klaus F Rabe, Henrik Watz
Chronic obstructive pulmonary disease (COPD) kills more than 3 million people worldwide every year. Despite progress in the treatment of symptoms and prevention of acute exacerbations, few advances have been made to ameliorate disease progression or affect mortality. A better understanding of the complex disease mechanisms resulting in COPD is needed. Smoking cessation programmes, increasing physical activity, and early detection and treatment of comorbidities are further key components to reduce the burden of the disease...
May 13, 2017: Lancet
https://www.readbyqxmd.com/read/28513197/uptake-of-telehealth-implementation-for-copd-patients-in-a-high-poverty-inner-city-environment-a-survey
#4
Catherine L Granger, Rachel Wijayarathna, Eui-Sik Suh, Gill Arbane, Linda Denehy, Patrick Murphy, Nicholas Hart
This study aimed to investigate computer and internet access and education attained in patients with chronic obstructive pulmonary disease (COPD) as potential barriers to implementation of telemedicine. We prospectively assessed 98 patients admitted with an acute exacerbation of COPD (mean age: 70.5 ± 9.3 years; force expired volume in the first second: 0.75 ± 0.39 L; 59% male) recording educational level attained and home computer and internet access. Hospital readmission surveillance occurred up to 2.7 (2...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28506729/-the-role-of-extracorporeal-removal-of-co2-ecco2r-in-the-management-of-respiratory-diseases
#5
J L Diehl, J Boisramé-Helms, A Chardon-Couteau, M Commereuc, J-L Augy, A Sokoloff, N Rivet, P Gaussem, D M Smadja, N Aissaoui
INTRODUCTION: The aim of extracorporeal removal of CO2 (ECCO2R) is to ensure the removal of CO2 without any significant effect on oxygenation. ECCO2R makes use of low to moderate extracorporeal blood flow rates, whereas extracorporeal membrane oxygenation (ECMO) requires high blood flows. STATE OF THE ART: For each ECCO2R device it is important to consider not only performance in terms of CO2 removal, but also cost and safety, including the incidence of hemolysis and of hemorrhagic and thrombotic complications...
May 12, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28506728/-the-effects-of-inhaled-steroids-withdrawal-in-copd
#6
G Jebrak, I Honore, P Serrier, J Dumoulin, P Terrioux, F Soyez, C Maurer, G Mangiapan, M Febvre, L-J Couderc, J-M Braun, T Chinet
The key pathophysiological feature of chronic obstructive pulmonary disease (COPD) is an abnormal inflammatory bronchial reaction after inhalation of toxic substances. The priority is the avoidance of such toxic inhalations, but the use of anti-inflammatory drugs also seems appropriate, especially corticosteroids that are the sole anti-inflammatory drug available for this purpose in France. The risks associated with the prolonged use of these parenteral drugs are well known. Inhalation is therefore the optimal route, but inhaled drugs may also lead to adverse consequences...
May 12, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28505687/-exacerbation-of-copd
#7
J Lorenz, R Bals, M Dreher, B Jany, R Koczulla, M Pfeifer, W Randerath, G Steinkamp, C Taube, H Watz, W Windisch
Acute worsenings of chronic obstructive pulmonary disease (COPD) were for a long time regarded as transient deteriorations, although occasionally life-threatening. No connection to disease progression was recognized. Data emerging during the last decade showed that patients had a considerably worse survival outcome after severe exacerbations. This insight was consolidated in 2012 by a large population-based cohort analysis. At present, severe exacerbations are regarded as key risk factors for COPD disease progression...
May 2017: Pneumologie
https://www.readbyqxmd.com/read/28502841/use-of-airway-epithelial-cell-culture-to-unravel-the-pathogenesis-and-study-treatment-in-obstructive-airway-diseases
#8
REVIEW
Tinne C J Mertens, Harry Karmouty-Quintana, Christian Taube, Pieter S Hiemstra
Asthma and chronic obstructive pulmonary disease (COPD) are considered as two distinct obstructive diseases. Both chronic diseases share a component of airway epithelial dysfunction. The airway epithelium is localized to deal with inhaled substances, and functions as a barrier preventing penetration of such substances into the body. In addition, the epithelium is involved in the regulation of both innate and adaptive immune responses following inhalation of particles, allergens and pathogens. Through triggering and inducing immune responses, airway epithelial cells contribute to the pathogenesis of both asthma and COPD...
May 11, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28502518/-management-of-acute-exacerbations-of-chronic-obstructive-pulmonary-disease-copd-guidelines-from-the-soci%C3%A3-t%C3%A3-de-pneumologie-de-langue-fran%C3%A3-aise-argumentary
#9
S Jouneau, N Roche
No abstract text is available yet for this article.
May 12, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28502414/acute-bronchodilator-responses-to-%C3%AE-2-agonist-and-anticholinergic-agent-in-copd-their-different-associations-with-exacerbation
#10
Satoshi Konno, Hironi Makita, Masaru Suzuki, Kaoruko Shimizu, Hirokazu Kimura, Hiroki Kimura, Masaharu Nishimura
BACKGROUND: Acute bronchodilator response (BDR) is a potential phenotypic characteristic of COPD. However, the clinical factors associated with BDR in patients with COPD remain unclear, particularly for BDR to anticholinergic agents. OBJECTIVES: We aimed to clarify the clinical factors associated with BDR to β2-agonist and/or anticholinergic agent, considering time-associated variations of BDR. We also evaluated the association between BDR and clinical course of COPD...
June 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28502370/-differential-diagnosis-of-acute-copd-exacerbations
#11
N Carlier
No abstract text is available yet for this article.
May 10, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28502368/-what-is-the-role-of-non-inhaled-drug-management-in-acute-copd-exacerbation
#12
H Morel
No abstract text is available yet for this article.
May 10, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28502366/-management-of-inpatients-with-acute-copd-exacerbation-when-to-indicate-mechanical-ventilation
#13
N Bèle
No abstract text is available yet for this article.
May 10, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28495296/-non-pharmacological-management-of-acute-copd-exacerbations-in-community-based-practice
#14
P Surpas, P Gouilly
No abstract text is available yet for this article.
May 8, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28490868/serum-il-1%C3%AE-and-il-17-levels-in-patients-with-copd-associations-with-clinical-parameters
#15
Yong Zou, Xi Chen, Jie Liu, Dong Bo Zhou, Xiao Kuang, Jian Xiao, Qiao Yu, Xiaoxiao Lu, Wei Li, Bin Xie, Qiong Chen
COPD is a chronic airway inflammatory disease characterized mainly by neutrophil airway infiltrations. Interleukin (IL)-1β and IL-17 are the key mediators of neutrophilic airway inflammation in COPD. This study was undertaken to evaluate the serum IL-1β and IL-17 levels and associations between these two key mediators with clinical parameters in COPD patients. Serum samples were collected from 60 COPD subjects during the acute exacerbation of COPD, 60 subjects with stable COPD and 40 healthy control subjects...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28485989/non-invasive-positive-airway-pressure-in-obesity-hypoventilation-syndrome-and-chronic-obstructive-pulmonary-disease-present-and-future-perspectives
#16
Victor R Ramírez-Molina, Francisco J Gómez-de-Terreros, Javier Barca-Durán, Juan F Masa
Obesity hypoventilation syndrome (OHS) is a sleep disorder that has acquired great importance worldwide because of its prevalence and association with obesity leading to increased morbidity and mortality with reduced quality of life. The primary feature is insufficient sleep-related ventilation, resulting in abnormally elevated arterial carbon dioxide pressure (PaCO2) during sleep and demonstration of daytime hypoventilation. There are three main mechanisms that can generate diurnal hypoventilation in obese patients: alteration of the respiratory mechanics secondary to obesity; central hypoventilation secondary to leptin resistance and sleep disorder with sleep hypoventilation and obstructive apnoeas, which can be potentially solved with the use of positive airway pressure: non-invasive ventilation (NIV) and continuous positive airway pressure (CPAP)...
May 9, 2017: COPD
https://www.readbyqxmd.com/read/28483402/doxycycline-for-outpatient-treated-acute-exacerbations-of-copd-a-randomised-double-blind-placebo-controlled-trial
#17
Patricia van Velzen, Gerben Ter Riet, Paul Bresser, Jeroen J Baars, Bob T J van den Berg, Jan W K van den Berg, Paul Brinkman, Jennece W F Dagelet, Johannes M A Daniels, Dewi R G L Groeneveld-Tjiong, René E Jonkers, Coen van Kan, Frans H Krouwels, Karin Pool, Arjan Rudolphus, Peter J Sterk, Jan M Prins
BACKGROUND: Antibiotics do not reduce mortality or short-term treatment non-response in patients receiving treatment for acute exacerbations of COPD in an outpatient setting. However, the long-term effects of antibiotics are unknown. The aim of this study was to investigate if the antibiotic doxycycline added to the oral corticosteroid prednisolone prolongs time to next exacerbation in patients with COPD receiving treatment for an exacerbation in the outpatient setting. METHODS: In this randomised double-blind placebo-controlled trial, we recruited a cohort of patients with COPD from outpatient clinics of nine teaching hospitals and three primary care centres in the Netherlands...
May 5, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28478693/effects-of-different-physical-therapy-programs-on-perceived-health-status-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-patients-a-randomized-clinical-trial
#18
Irene Torres-Sánchez, Marie Carmen Valenza, Maria Dels Àngels Cebriá I Iranzo, Laura López-López, Ma Paz Moreno-Ramírez, Araceli Ortíz-Rubio
PURPOSE: To evaluate the repercussion of different physical therapy interventions on the perceived health status of chronic obstructive pulmonary disease (COPD) patients during acute exacerbation. MATERIALS AND METHODS: Randomized controlled trial. Patients were assigned to: control group (standard medical treatment), controlled breathing + range of motion exercises group or Resistance exercises group. Perceived health status was assessed at baseline and discharge using the EuroQol-5D (EQ-5D) questionnaire...
May 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28476471/elevated-levels-of-circulating-exosome-in-copd-patients-are-associated-with-systemic-inflammation
#19
Dino B A Tan, Jesse Armitage, Teck-Hui Teo, Nathanael E Ong, Heewoong Shin, Yuben P Moodley
Chronic obstructive pulmonary disease (COPD) is characterized by progressive pulmonary and systemic inflammation. Acute exacerbations of COPD (AECOPD) are associated with acute inflammation and infections and increase the rates of morbidity and mortality. Currently, neither the aetiology nor pathogenesis of AECOPD are entirely understood. Exosomes have been reported to regulate immunity and inflammation via specific intercellular communications through an array of macromolecules (e.g. microRNA and proteins) contained within these microvesicles...
April 26, 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28476419/-impact-of-acute-copd-exacerbation-and-repetitive-episodes-on-the-disease-evolution
#20
P R Burgel
No abstract text is available yet for this article.
May 2, 2017: Revue des Maladies Respiratoires
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