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Lung cancer review

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https://www.readbyqxmd.com/read/29235400/role-of-bevacizumab-in-the-management-of-the-patient-with-malignant-pleural-effusion-more-questions-than-answers
#1
Ralph Llewel Sabang, Deepthi Gandhiraj, Michael Fanucchi, Oleg Epelbaum
Malignant pleural effusion (MPE) is a feature of metastatic cancer that is associated with significant morbidity and healthcare costs. The typical current management of MPE involves the combination of systemic chemotherapy and mechanical intervention in the pleural space. Vascular endothelial growth factor (VEGF), an extremely potent inducer of vascular permeability, has been shown to mediate fluid formation in pleural malignancy. Therefore, bevacizumab, an inhibitor of VEGF activity, offers theoretical promise as a means of abolishing fluid formation in MPE...
December 13, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29234607/lobectomy-versus-sublobar-resection-in-non-lepidic-small-sized-non-small-cell-lung-cancer
#2
Min Namkoong, Youngkyu Moon, Jae Kil Park
Background: Recently, many surgeons have chosen sublobar resection for the curative treatment of lung tumors with ground-glass opacity, which is a hallmark of lepidic lung cancer. The purpose of this study was to evaluate the oncological results of sublobar resection for non-lepidic lung cancer in comparison with lobectomy. Methods: We conducted a retrospective chart review of 328 patients with clinical N0 non-small cell lung cancer sized ≤2 cm who underwent curative surgical resection from January 2009 to December 2014...
December 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29234363/shenfu-injection-adjunct-with-platinum-based-chemotherapy-for-the-treatment-of-advanced-non-small-cell-lung-cancer-a-meta-analysis-and-systematic-review
#3
REVIEW
Ailing Cao, Hailang He, Mengxin Jing, Beibei Yu, Xianmei Zhou
Platinum-based chemotherapy is one of the standard treatments for non-small-cell lung cancer (NSCLC), while its high toxicity and limited clinical effects raise big concerns. Shenfu injection (SFI) has been commonly used as an adjutant chemotherapy drug for NSCLC in China. We ascertained the beneficial and adverse effects of SFI in combination with platinum-based chemotherapy for advanced NSCLC by using meta-analysis methods. The randomized controlled trials (RCTs) involving advanced NSCLC treatment with SFI plus platinum-based chemotherapy versus chemotherapy alone were searched on 6 medical databases up to February 2017...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29232243/artifactual-hepatic-metastasis-on-fdg-pet-ct-secondary-to-cryoablation-for-adrenal-metastasis
#4
Joseph Frankl, Naghmehossadat Eshghi, Tamara F Lundeen, Phillip H Kuo
A 65-year-old woman with metastatic lung cancer was referred for CT-guided cryoablation of a right adrenal metastasis. For cryoablation, probes were placed into the adrenal region. FDG PET/CT 3 months later showed new activity in hepatic segment 6 initially suspected to be metastasis. Proximity of the hepatic lesion to the adrenal metastasis was a strange coincidence and prompted review of imaging from the cryoablation. CT showed the probe entered the liver, and postablation image demonstrated injury to the liver adjacent to the adrenal metastasis...
December 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29232184/feasibility-and-safety-of-intrathoracic-biopsy-and-repeat-biopsy-for-evaluation-of-programmed-cell-death-ligand-1-expression-for-immunotherapy-in-non-small-cell-lung-cancer
#5
Emily B Tsai, Kelsey Pomykala, Kathleen Ruchalski, Scott Genshaft, Fereidoun Abtin, Antonio Gutierrez, Hyun J Kim, Alice Li, Carlos Adame, Ashkan Jalalian, Brian Wolf, Edward B Garon, Jonathan W Goldman, Robert Suh
Purpose To determine feasibility and safety of biopsy and repeat biopsy for assessment of programmed cell death ligand-1 (PD-L1) status. Materials and Methods This retrospective analysis reviewed 101 patients who underwent transthoracic core needle biopsy for the KEYNOTE-001 (MK-3475) clinical trial of pembrolizumab, an antiprogrammed cell death-1 therapy for non-small cell lung cancer, from May 2012 to September 2014. Sixty-one male patients (mean age, 66.1 years; range 36-83 years) and 40 female patients (mean age, 66...
December 12, 2017: Radiology
https://www.readbyqxmd.com/read/29231759/screening-for-lung-cancer-incidental-pulmonary-parenchymal-findings
#6
Jonathan H Chung, J Caleb Richards, Tilman L Koelsch, Heber MacMahon, David A Lynch
OBJECTIVE: Incidental pulmonary findings are commonly detected at lung cancer screening chest CT. Though most of these findings are clinically insignificant, it is difficult to prospectively determine which are potentially important to clinical care. The purpose of this review is to discuss the incidental pulmonary findings commonly detected at lung cancer screening chest CT. CONCLUSION: Incidental pulmonary findings most commonly fall into one of three categories: interstitial lung disease, emphysema, and airways disease (both small and large airways)...
December 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29230653/environmental-exposure-to-cadmium-a-risk-for-health-of-the-general-population-in-industrialized-countries-and-preventive-strategies
#7
Magdalena Mezynska, Malgorzata M Brzóska
Cadmium (Cd) is a heavy metal belonging to the group of the main chemical pollutants of the natural and occupational environment in economically developed countries. The forecasts indicate that contamination of the environment with this toxic metal, and thus the exposure of the general population, will increase. Food (particularly plant products) is the main source of the general population exposure to this element. Moreover, an important, and often the main, source of intoxication with Cd is habitual tobacco smoking...
December 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29230123/molecular-targets-in-non-small-cell-lung-cancer
#8
REVIEW
Ryan Griffin, Robert A Ramirez
Background: Lung cancer is the second most common cancer in the United States among men and women, and it is the most common cause of cancer-related death. Non-small cell lung cancer (NSCLC) represents approximately 85% of all lung cancer cases. Historically, patients with metastatic NSCLC received similar cytotoxic chemotherapy regimens. Genotyping studies have revealed genetic/molecular abnormalities in lung cancer. These driver mutations render a cancer dependent on that specific mutation's biochemical pathway for its growth and survival...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29230122/the-role-of-checkpoint-inhibition-in-non-small-cell-lung-cancer
#9
REVIEW
Jonathan Lu, Robert A Ramirez
Background: The development of immune checkpoint inhibitors has revolutionized the treatment of cancer. Their use in non-small cell lung cancer (NSCLC) remains in its infancy, but rapid progress has been made in treating metastatic NSCLC. Methods: This article outlines the role of immune checkpoint inhibitors in the treatment of malignancy and reviews clinical trials of novel immunotherapies in the setting of metastatic NSCLC. Results: Traditional chemotherapy with a platinum-based doublet has long been the backbone in the treatment of metastatic NSCLC...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29230121/leptomeningeal-disease-and-the-evolving-role-of-molecular-targeted-therapy-and-immunotherapy
#10
REVIEW
Katharine Hall Thomas, Robert A Ramirez
Background: Leptomeningeal disease (LMD) is a complication that results from solid tumor metastasis. Prognosis is extremely poor. As therapeutic options for solid tumors improve, the rate of LMD continues to increase. Until recently, treatment has been limited to radiation therapy, intrathecal chemotherapy, and systemic chemotherapy, with an overall survival of 2-3 months. Targeted molecular therapy and immunotherapies are promising new options for increasing overall survival and clinical improvement; however, optimal clinical management remains unknown...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29229669/kras-the-critical-driver-and-therapeutic-target-for-pancreatic-cancer
#11
Andrew M Waters, Channing J Der
RAS genes (HRAS, KRAS, and NRAS) comprise the most frequently mutated oncogene family in human cancer. With the highest RAS mutation frequencies seen with the top three causes of cancer deaths in the United States (lung, colorectal, and pancreatic cancer), the development of anti-RAS therapies is a major priority for cancer research. Despite more than three decades of intense effort, no effective RAS inhibitors have yet to reach the cancer patient. With bitter lessons learned from past failures and with new ideas and strategies, there is renewed hope that undruggable RAS may finally be conquered...
December 11, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29228994/survival-and-prognostic-factors-of-non-small-cell-lung-cancer-patients-with-postoperative-locoregional-recurrence-treated-with-radical-radiotherapy
#12
Li Ma, Bo Qiu, Jun Zhang, Qi-Wen Li, Bin Wang, Xu-Hui Zhang, Meng-Yun Qiang, Zhao-Lin Chen, Su-Ping Guo, Hui Liu
BACKGROUND: Locoregional recurrence remains the challenge for long-term survival of non-small cell lung cancer (NSCLC) patients after radical surgery, and curative-intent radiotherapy could be a treatment choice. This study aimed to assess the survival and prognostic factors of patients with postoperative locoregionally recurrent NSCLC treated with radical radiotherapy. METHODS: We reviewed medical records of 74 NSCLC patients with postoperative locoregional recurrence who received radical radiotherapy between April 2012 and February 2016 at Sun Yat-sen University Cancer Center (Guangzhou, China)...
December 11, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29228697/egfr-mutation-smoking-and-gender-in-advanced-lung-adenocarcinoma
#13
Chien-Hua Tseng, Chun-Ju Chiang, Jeng-Sen Tseng, Tsung-Ying Yang, Kuo-Hsuan Hsu, Kun-Chieh Chen, Chih-Liang Wang, Chih-Yi Chen, Sang-Hue Yen, Chun-Ming Tsai, Ming-Shyan Huang, Chao-Chi Ho, Chong-Jen Yu, Ying-Huang Tsai, Jin-Shing Chen, Teh-Ying Chou, Ming-Hsun Tsai, Hsuan-Yu Chen, Kang-Yi Su, Jeremy J W Chen, Huei-Wen Chen, Sung-Liang Yu, Tsang-Wu Liu, Gee-Chen Chang
Purpose: In the current targeted therapy era, information on the effect of smoking in epidermal growth factor receptor (EGFR)-mutant lung cancer patients is scarce. Results: In total, 11,678 adenocarcinoma patients were enrolled. Of these, 33.3% and 91.8% of male and female patients were non-smokers, respectively. An increased amount of smoking (P < 0.001 for trend), fewer smoke-free years (P < 0.001 for trend), and younger age of smoking initiation (P = 0...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228529/efficacy-of-bronchial-washing-and-brushing-cytology-in-the-diagnosis-of-non-neoplastic-lung-diseases
#14
Rahil Giti, Massood Hosseinzadeh
Flexible fiberoptic bronchoscopy is often the initial technique for diagnosis of lung and bronchial tumors. Many studies have shown the high accuracy rate of bronchial washing and brushing cytology in the evaluation of neoplastic and non-neoplastic bronchopulmonary lesions. The aim of this study is to emphasize the value of the bronchial cytologic findings for diagnosis of non-neoplastic bronchopulmonary lesions. In a cross-sectional study, we retrieved all cases with bronchial washing and brushing cytology from 21 Mach 2014 to 21 December 2015...
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29228138/american-society-of-anesthesiologists-physical-status-facilitates-risk-stratification-of-elderly-patients-undergoing-thoracoscopic-lobectomy
#15
Ruoyu Zhang, Thomas Kyriss, Jürgen Dippon, Matthias Hansen, Enole Boedeker, Godehard Friedel
OBJECTIVES: Accurate risk assessments are particularly important for elderly patients being considered for lobectomy. Considering the positive effects of the thoracoscopic approach on postoperative outcomes, we sought to review the reliability of the established risk factors for elderly patients undergoing thoracoscopic lobectomy. METHODS: From January 2009 to March 2016, 441 patients in our institution underwent thoracoscopic lobectomy for early-stage lung cancer...
December 8, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29228042/risk-of-thromboembolism-in-cisplatin-versus-carboplatin-treated-patients-with-lung-cancer
#16
Eric S Kim, Andrea M Baran, Esther L Mondo, Thomas D Rodgers, Gradon C Nielsen, David W Dougherty, Kishan J Pandya, David Q Rich, Edwin van Wijngaarden
INTRODUCTION: Carboplatin is widely used to treat lung cancer in the United States as an alternative to cisplatin. Several studies have demonstrated that cisplatin-based regimen is associated with a high frequency of thromboembolic complications. However, there has been limited investigation directly comparing the risk of thromboembolic events (TEEs) between cisplatin- and carboplatin-treated patients with lung cancer. METHODS: All lung cancer patients treated with cisplatin or carboplatin at Wilmot Cancer Center, University of Rochester between 2011 and 2014 were included...
2017: PloS One
https://www.readbyqxmd.com/read/29227909/navigating-the-no-man-s-land-of-tki-failed-egfr-mutated-non-small-cell-lung-cancer-nsclc-a-review
#17
REVIEW
Bryan Oronsky, Patrick Ma, Tony R Reid, Pedro Cabrales, Michelle Lybeck, Arnold Oronsky, Neil Oronsky, Corey A Carter
As the leading cause of cancer-related mortality, lung cancer is a worldwide health issue that is overwhelmingly caused by smoking. However, a substantial minority (~25%) of patients with non-small cell lung cancer (NSCLC) has never smoked. In these patients, activating mutations of the epidermal growth factor receptor (EGFR) are more likely, which render their tumors susceptible for a finite period to treatment with EGFR tyrosine kinase inhibitors (TKIs) and confer a better prognosis than EGFR wild-type NSCLC...
December 8, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29227119/-molecular-pathology-of-lung-cancer-in-routine-diagnostic-practice-2017-update
#18
Radoslav Matěj, Zdeněk Rohan, Kristýna Němejcová, Pavel Dundr
The group of non-small cell lung carcinomas includes tumors that are variable at the clinical, histopathological and molecular levels. Advances in the understanding of molecular pathology of lung adenocarcinomas in particular led to changes in their histopathological classification and treatment. Patients diagnosed with lung adenocarcinoma harboring specific mutations benefit from the administration of specific targeted therapy. Analysis of EGFR gene mutations and ALK rearrangement in lung adenocarcinomas are already routinely performed and are closely related to the indication for the administration of tyrosinkinase inhibitors...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/29226712/-risk-stratification-before-thoracic-surgery-perioperative-pulmonary-rehabilitation
#19
Attila Vágvölgyi, Zsolt Rozgonyi, Pál Vadász, János Tamás Varga
INTRODUCTION: Besides the oncology and operative surgical technics, functional aspects influence the operability of lung cancer. Preoperative risk stratification, evaluation of postoperative complications needs to be considered. AIM: To review international literature and experiences of our institute. METHOD: We focused the literature of risk stratification of thoracic surgery. Lung function, lung mechanics, chest kinematics, exercise physiology were considered...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29226461/long-non-coding-pandar-as-a-novel-biomarker-in-human-cancer-a-systematic-review
#20
REVIEW
Yifan Zou, Yuantang Zhong, Junjie Wu, Huizhong Xiao, Xintao Zhang, Xinhui Liao, Jianfa Li, Xuhua Mao, Yuchen Liu, Fuyou Zhang
OBJECTIVES: Long non-coding RNAs (lncRNAs) are characterized as a group of RNAs that more than 200 nucleotides in length and have no protein-coding function. More and more evidences provided that lncRNAs serve as key molecules in the development of cancer. Deregulation of lncRNAs functions as either oncogenes or tumour suppressor genes in various diseases. Recently, increasing studies about PANDAR in cancer progression were reported. In our review, we will focus on the current research on the character of PANDAR include the clinical management, tumour progression and molecular mechanisms in human cancers...
December 10, 2017: Cell Proliferation
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