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https://www.readbyqxmd.com/read/29042382/drugs-and-life-threatening-ventricular-arrhythmia-risk-results-from-the-dare-study-cohort
#1
Abigail L Coughtrie, Elijah R Behr, Deborah Layton, Vanessa Marshall, A John Camm, Saad A W Shakir
OBJECTIVES: To establish a unique sample of proarrhythmia cases, determine the characteristics of cases and estimate the contribution of individual drugs to the incidence of proarrhythmia within these cases. SETTING: Suspected proarrhythmia cases were referred by cardiologists across England between 2003 and 2011. Information on demography, symptoms, prior medical and drug histories and data from hospital notes were collected. PARTICIPANTS: Two expert cardiologists reviewed data for 293 referred cases: 130 were included...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29023786/response-to-flecainide-test-in-andersen-tawil-syndrome-with-incessant-ventricular-tachycardia
#2
Marcos Fernández, María Del Rosario Marín, Juan Fernández-Armenta, Francisco Mora-López, Rafael Fernández Rivero, Antonio Berruezo, Lucas Cano Calabria, Rafael Vázquez García
No abstract text is available yet for this article.
October 12, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29016756/the-electrocardiogram-as-a-predictor-of-successful-pharmacological-cardioversion-and-progression-of-atrial-fibrillation
#3
Stef Zeemering, Theo A R Lankveld, Pietro Bonizzi, Ione Limantoro, Sebastiaan C A M Bekkers, Harry J G M Crijns, Ulrich Schotten
Aims: Non-invasive characterization of atrial fibrillation (AF) substrate complexity based on the electrocardiogram (ECG) may improve outcome prediction in patients receiving rhythm control therapies for AF. Multiple parameters to assess AF complexity and predict treatment outcome have been suggested. A comparative study of the predictive performance of complexity parameters on response to therapy and progression of AF in a large patient population is needed to standardize non-invasive analysis of AF...
July 26, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28956012/flecainide-ameliorates-arrhythmogenicity-through-ncx-flux-in-andersen-tawil-syndrome-ips-cell-derived-cardiomyocytes
#4
Yusuke Kuroda, Shinsuke Yuasa, Yasuhide Watanabe, Shogo Ito, Toru Egashira, Tomohisa Seki, Tetsuhisa Hattori, Seiko Ohno, Masaki Kodaira, Tomoyuki Suzuki, Hisayuki Hashimoto, Shinichiro Okata, Atsushi Tanaka, Yoshiyasu Aizawa, Mitsushige Murata, Takeshi Aiba, Naomasa Makita, Tetsushi Furukawa, Wataru Shimizu, Itsuo Kodama, Satoshi Ogawa, Norito Kokubun, Hitoshi Horigome, Minoru Horie, Kaichiro Kamiya, Keiichi Fukuda
Andersen-Tawil syndrome (ATS) is a rare inherited channelopathy. The cardiac phenotype in ATS is typified by a prominent U wave and ventricular arrhythmia. An effective treatment for this disease remains to be established. We reprogrammed somatic cells from three ATS patients to generate induced pluripotent stem cells (iPSCs). Multi-electrode arrays (MEAs) were used to record extracellular electrograms of iPSC-derived cardiomyocytes, revealing strong arrhythmic events in the ATS-iPSC-derived cardiomyocytes...
March 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28948151/unusual-severe-hemodynamic-failure-associated-with-standard-dose-of-intravenous-flecainide-for-pharmacological-cardioversion-of-atrial-fibrillation
#5
Aref Albakri, Thomas Klingenheben
No abstract text is available yet for this article.
September 2017: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/28928617/flecainide-toxicity-in-a-preterm-neonate-with-permanent-junctional-reciprocating-tachycardia
#6
Balaganesh Karmegaraj, Danish Menon, Mukund A Prabhu, Balu Vaidyanathan
We report a case of flecainide toxicity in a premature neonate with permanent junctional reciprocating tachycardia which was managed successfully by reversal of the sodium blockade with intravenous sodium bicarbonate and supportive care. This report highlights the importance of strict supervision and monitoring while administering antiarrhythmic drugs in neonates and prompt institution of appropriate remedial action for treatment when toxicity is suspected.
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28917079/insulin-autoimmune-syndrome-hirata-s-disease-in-an-italian-patient-a-case-report-and-review-of-the-literature
#7
REVIEW
Simona Censi, Maria Paola Albergoni, Nicoletta Gallo, Mario Plebani, Marco Boscaro, Corrado Betterle
We describe the case of a 54-year-old Caucasian Italian male experiencing episodes of hypoglycemia, occurring mainly after meals. He had never been exposed to insulin and was taking ramipril, flecainide and acetylsalicylic acid. An oral glucose tolerance test (OGTT) showed high blood glucose levels diagnostic for diabetes mellitus at 120 min and hypoglycemia with inappropriately high insulin levels at 240 min. The 72-h fasting test, abdominal computed tomography (CT) and positron emission tomography-CT were normal...
September 16, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28911031/flecainide-overdose-induced-brugada-electrocardiogram-pattern
#8
M C Y Nam, E-A Karlsen, E Woo, N Dayananda, K Greaves, T Stanton
No abstract text is available yet for this article.
September 1, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28864237/-comparison-of-the-efficacy-and-safety-of-dronedarone-and-flecainide-like-maintenance-antiarrhythmic-therapy-for-sinus-rhytm-in-atrial-fibrillation
#9
Ruth María Sánchez Soriano, Carlos Israel Chamorro Fernández, Juan Miguel Ruiz Nodar, Antonio Javier Chamorro Fernández, Guillermo Grau Jornet, Julio Nuñez Villota
INTRODUCTION AND OBJECTIVES: Dronedarone and flecainide are first pharmacological choice to reduce recurrence of atrial fibrillation (AF); however, there are no studies comparing each other. We sought to compare the efficacy in terms of recurrence of AF and safety of both drugs. METHODS: This is a retrospective cohort study including 123 consecutive patients treated with flecainide or dronedarone due to paroxismal AF (76.4%) or persistent AF (23.6%), from October 2010 to February 2013...
August 29, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28854511/neonatal-complex-arrhythmias-possibly-related-to-a-ttn-mutation
#10
William N Evans, Ruben J Acherman, Ian H Law, Nicholas H Von Bergen, Ricardo A Samson, Humberto Restrepo
We describe a neonate born with complex arrhythmias that included concurrent atrial and ventricular tachycardias. Genetic testing demonstrated a mutation in the TTN gene, which codes for titin, a large protein found in striated muscle sarcomeres. The complex arrhythmias were successfully treated with amiodarone and flecainide. The patient remains asymptomatic with normal biventricular function. We speculate that the complex arrhythmias and TTN gene mutation may be related.
August 23, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28851790/antenatal-antiarrhythmic-treatment-for-fetal-tachyarrhythmias-a-study-protocol-for-a-prospective-multicentre-trial
#11
Takekazu Miyoshi, Yasuki Maeno, Haruhiko Sago, Noboru Inamura, Satoshi Yasukochi, Motoyoshi Kawataki, Hitoshi Horigome, Hitoshi Yoda, Mio Taketazu, Makio Shozu, Masaki Nii, Akiko Hagiwara, Hitoshi Kato, Wataru Shimizu, Isao Shiraishi, Heima Sakaguchi, Keiko Ueda, Shinji Katsuragi, Tomoaki Ikeda, Haruko Yamamoto, Toshimitsu Hamasaki
INTRODUCTION: Several retrospective or single-centre studies demonstrated the efficacy of transplacental treatment of fetal tachyarrhythmias. Our retrospective nationwide survey showed that the fetal therapy will be successful at an overall rate of 90%. For fetuses with hydrops, the treatment success rate will be 80%. However, standard protocol has not been established. The objective of this study is to evaluate the efficacy and safety of the protocol-defined transplacental treatment of fetal tachyarrhythmias...
August 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28840327/the-safety-and-effectiveness-of-flecainide-in-children-in-the-current-era
#12
Taylor Cunningham, Orhan Uzun, Rachel Morris, Sonia Franciosi, Amos Wong, Ida Jeremiasen, Elizabeth Sherwin, Shubhayan Sanatani
This retrospective study sought to determine the safety and effectiveness of flecainide in children with normal hearts and those with congenital heart disease (CHD) or cardiomyopathy (CMO). Baseline and follow-up data at two pediatric cardiology sites were queried (2000-2015); a total of 175 patients (20 with CHD and two with CMO) receiving flecainide were assessed. When comparing patients with CHD to those with normal hearts, patients with CHD were younger at diagnosis (median age 19 days; IQR 3-157.5 days vs normal heart patients median age 21 days; IQR 7-172 days, p = 0...
August 24, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28837652/an-infrared-optical-pacing-system-for-screening-cardiac-electrophysiology-in-human-cardiomyocytes
#13
Matthew T McPheeters, Yves T Wang, Andreas A Werdich, Michael W Jenkins, Kenneth R Laurita
Human cardiac myocytes derived from pluripotent stem cells (hCM) have invigorated interest in genetic disease mechanisms and cardiac safety testing; however, the technology to fully assess electrophysiological function in an assay that is amenable to high throughput screening has lagged. We describe a fully contactless system using optical pacing with an infrared (IR) laser and multi-site high fidelity fluorescence imaging to assess multiple electrophysiological parameters from hCM monolayers in a standard 96-well plate...
2017: PloS One
https://www.readbyqxmd.com/read/28833310/transplacental-treatment-of-fetal-tachycardia-a-systematic-review-and-meta-analysis
#14
Garick D Hill, Joshua R Kovach, David E Saudek, Anoop K Singh, Karla Wehrheim, Michele A Frommelt
OBJECTIVE: Multiple transplacental medications can be used to treat fetal tachycardia. We sought to perform a systematic review and meta-analysis to determine whether digoxin, flecainide or sotalol was the most efficacious therapy for converting fetal tachycardia to sinus rhythm. METHOD: We performed a systematic review and meta-analysis to compare digoxin, flecainide or sotalol as first-line therapy for fetal tachycardia. Studies were identified by a search of PubMed (Medline), Web of Science, and Scopus...
August 22, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28789916/flecainide-reduces-ventricular-arrhythmias-in-patients-with-genotype-ryr2-positive-catecholaminergic-polymorphic-ventricular-tachycardia
#15
Fernando Wangüemert Pérez, Julio Salvador Hernández Afonso, María Del Val Groba Marco, Eduardo Caballero Dorta, Luis Álvarez Acosta, Oscar Campuzano Larrea, Guillermo Pérez, Josep Brugada Terradellas, Ramón Brugada Terradellas
INTRODUCTION AND OBJECTIVES: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease characterized by polymorphic or bidirectional ventricular arrhythmias (VA) triggered by physical or emotional stress in young people with a structurally normal heart. Beta-blockers are the cornerstone of treatment, while flecainide has recently been incorporated into the therapeutic arsenal. The aim of this study was to report our experience with this drug. METHODS: The cohort included 174 genotype-positive CPVT-patients from 7 families...
August 5, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28765762/paroxysmal-atrial-fibrillation-recurrences-and-quality-of-life-in-symptomatic-patients-a-crossover-study-of-flecainide-and-pilsicainide
#16
Tsuyoshi Shiga, Koichiro Yoshioka, Eiichi Watanabe, Hisako Omori, Masahiro Yagi, Yasuo Okumura, Naoki Matsumoto, Kengo Kusano, Chikara Oshiro, Takanori Ikeda, Naohiko Takahashi, Takashi Komatsu, Atsushi Suzuki, Tsuyoshi Suzuki, Yasuto Sato, Takeshi Yamashita
BACKGROUND: The therapeutic goals of atrial fibrillation (AF) patients are to reduce symptoms and prevent severe complications associated with AF. This study compared the efficacy of flecainide versus pilsicainide in reducing the frequency of AF and improving quality of life (QOL) in symptomatic paroxysmal AF patients without structural heart disease. METHODS: The Atrial Fibrillation and Quality Of Life (AF-QOL) study was a prospective, multicenter, randomized, open-label crossover study that compared flecainide and pilsicainide as antiarrhythmic drug therapy...
August 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28740174/plakophilin-2-is-required-for-transcription-of-genes-that-control-calcium-cycling-and-cardiac-rhythm
#17
Marina Cerrone, Jerome Montnach, Xianming Lin, Yan-Ting Zhao, Mingliang Zhang, Esperanza Agullo-Pascual, Alejandra Leo-Macias, Francisco J Alvarado, Igor Dolgalev, Thomas V Karathanos, Kabir Malkani, Chantal J M Van Opbergen, Joanne J A van Bavel, Hua-Qian Yang, Carolina Vasquez, David Tester, Steven Fowler, Fengxia Liang, Eli Rothenberg, Adriana Heguy, Gregory E Morley, William A Coetzee, Natalia A Trayanova, Michael J Ackerman, Toon A B van Veen, Hector H Valdivia, Mario Delmar
Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in cell-cell adhesion. Mutations in human PKP2 associate with a life-threatening arrhythmogenic cardiomyopathy, often of right ventricular predominance. Here, we use a range of state-of-the-art methods and a cardiomyocyte-specific, tamoxifen-activated, PKP2 knockout mouse to demonstrate that in addition to its role in cell adhesion, PKP2 is necessary to maintain transcription of genes that control intracellular calcium cycling. Lack of PKP2 reduces expression of Ryr2 (coding for Ryanodine Receptor 2), Ank2 (coding for Ankyrin-B), Cacna1c (coding for CaV1...
July 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28720014/the-impact-of-intrauterine-treatment-on-fetal-tachycardia-a-nationwide-survey-in-japan
#18
Keiko Ueda, Yasuki Maeno, Takekazu Miyoshi, Noboru Inamura, Motoyoshi Kawataki, Mio Taketazu, Masaki Nii, Akiko Hagiwara, Hitoshi Horigome, Makio Shozu, Wataru Shimizu, Satoshi Yasukochi, Hitoshi Yoda, Isao Shiraishi, Heima Sakaguchi, Shinji Katsuragi, Haruhiko Sago, Tomoaki Ikeda
OBJECTIVES: To investigate the clinical course of fetal tachycardia and analyze the impact of intrauterine treatment on the postnatal treatment and patient outcomes. STUDY DESIGN: This was a retrospective review of cases of fetal tachycardia that occurred from 2004 to 2006. Data were collected from questionnaires that were sent to all 750 secondary or tertiary perinatal care centers in Japan. RESULTS: Eighty-two cases (14 with fetal hydrops) were analyzed (supraventricular tachycardia [SVT], n = 52; atrial flutter [AFL], n = 23; and ventricular tachycardia, n = 7)...
July 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28707396/role-of-abnormal-repolarization-in-the-mechanism-of-cardiac-arrhythmia
#19
O E Osadchii
In cardiac patients, life-threatening tachyarrhythmia is often precipitated by abnormal changes in ventricular repolarization and refractoriness. Repolarization abnormalities typically evolve as a consequence of impaired function of outward K(+) currents in cardiac myocytes, which may be caused by genetic defects or result from various acquired pathophysiological conditions, including electrical remodelling in cardiac disease, ion channel modulation by clinically used pharmacological agents, and systemic electrolyte disorders seen in heart failure, such as hypokalaemia...
July 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28706272/modeling-atrial-fibrillation-using-human-embryonic-stem-cell-derived-atrial-tissue
#20
Zachary Laksman, Marianne Wauchop, Eric Lin, Stephanie Protze, Jeehoon Lee, Wallace Yang, Farzad Izaddoustdar, Sanam Shafaattalab, Lior Gepstein, Glen F Tibbits, Gordon Keller, Peter H Backx
Since current experimental models of Atrial Fibrillation (AF) have significant limitations, we used human embryonic stem cells (hESCs) to generate an atrial-specific tissue model of AF for pharmacologic testing. We generated atrial-like cardiomyocytes (CMs) from hESCs which preferentially expressed atrial-specific genes, and had shorter action potential (AP) durations compared to ventricular-like CMs. We then generated confluent atrial-like CM sheets and interrogated them using optical mapping techniques. Atrial-like CM sheets (~1 cm in diameter) showed uniform AP propagation, and rapid re-entrant rotor patterns, as seen in AF could be induced...
July 13, 2017: Scientific Reports
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