Patrick O Hanafin, Andrea Kwa, Alexandre P Zavascki, Ana Maria Sandri, Marc H Scheetz, Christine J Kubin, Jayesh Shah, Benjamin P Z Cherng, Michael T Yin, Jiping Wang, Lu Wang, David P Calfee, Maureen Bolon, Jason M Pogue, Anthony W Purcell, Roger L Nation, Jian Li, Keith S Kaye, Gauri G Rao
OBJECTIVES: To develop a population pharmacokinetic (PK) model with data from the largest polymyxin B-treated patient population studied to date to optimise its dosing in hospitalised patients. METHODS: Hospitalised patients receiving intravenous polymyxin B for ≥48h were enrolled. Blood samples were collected at steady-state and drug concentrations were analysed by LC-MS/MS. Population PK analysis and Monte Carlo simulations were performed to determine the probability of target attainment (PTA)...
May 20, 2023: Clinical Microbiology and Infection