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https://www.readbyqxmd.com/read/27698760/part-of-plasmapheresis-with-plasma-filtration-adsorption-combined-with-continuous-hemodiafiltration-in-the-treatment-of-severe-acute-liver-failure
#1
Maoqin Li, Zhidong Wang, Yining Wang, Changhong Du, Songhai Li, Zaixiang Shi, Bo Lu
The present study is a retrospective analysis of 11 cases with severe acute liver failure combined with multiple organ dysfunction syndrome (MODS) performed during the period June, 2012 to December, 2014. After part of plasmapheresis with plasma filtration adsorption combined with continuous hemodiafiltration treatment, good curative effects were obtained and the main clinical symptoms and biochemical index were significantly improved. Following treatment, 8 of the 11 patients survived at a survival rate of 72...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27628437/population-pharmacokinetics-of-daptomycin-in-adult-patients-undergoing-continuous-renal-replacement-therapy
#2
Xiaoying Xu, Dmytro Khadzhynov, Harm Peters, Ricardo L Chaves, Kamal Hamed, Micha Levi, Natascia Corti
AIM: The objective of this population pharmacokinetic (PK) analysis was to provide guidance for the dosing interval of daptomycin in patients undergoing continuous renal replacement therapy (CRRT). METHODS: A previously published population PK model for daptomycin was updated with data from patients undergoing continuous veno-venous haemodialysis (CVVHD; n = 9) and continuous veno-venous haemodiafiltration (CVVHDF; n = 8). Model-based simulations were performed to compare the 24 h AUC, Cmax and Cmin of daptomycin following various dosing regimens (4, 6, 8, 10, and 12 mg kg(-1) every [Q] 24 h and Q48 h), with the safety and efficacy exposure references for Staphylococcus aureus bacteraemia/right-sided infective endocarditis...
September 15, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27536658/continuous-renal-replacement-therapy-for-acute-renal-failure-in-patients-with-cancer-a-well-tolerated-adjunct-treatment
#3
Rebecca Fischler, Anne-Pascale Meert, Jean-Paul Sculier, Thierry Berghmans
INTRODUCTION: Acute renal failure (ARF) has a poor prognosis in patients with cancer requiring intensive care unit (ICU) admission. Our aim is finding prognostic factors for hospital mortality in patients with cancer with ARF requiring renal replacement therapy (RRT). METHODS: In this retrospective study, all patients with cancer with ARF treated with continuous venovenous filtration (CVVHDF) in the ICU of the Institut Jules Bordet, between January 1, 2003 and December 31, 2012, were included...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27531848/use-of-continuous-renal-replacement-therapy-in-salicylate-toxicity-a-case-report-and-review-of-the-literature
#4
Michael F Papacostas, Margaret Hoge, Michel Baum, Samuel Z Davila
OBJECTIVE: To report a case of salicylate toxicity treated with continuous venovenous hemodiafiltration (CVVHDF) and review the literature regarding the use of continuous renal replacement therapy (CRRT) for salicylate toxicity. CASE: A 16-year-old male presented after ingesting 1901 mg/kg of enteric coated aspirin. Salicylate level was 92 mg/dl 4 h after ingestion. Sequele included seizure, acute kidney injury, pulmonary edema, and prolonged QTc. He received 5...
September 2016: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/27474468/challenge-for-higher-colistin-dosage-in-critically-ill-patients-receiving-continuous-venovenous-haemodiafiltration
#5
Ilias Karaiskos, Lena E Friberg, Lambrini Galani, Konstantinos Ioannidis, Emmanouela Katsouda, Zoe Athanassa, Harris Paskalis, Helen Giamarellou
Traditionally, reduced daily doses of colistin methanesulphonate (CMS) in critically ill patients receiving continuous venovenous haemodiafiltration (CVVHDF) have resulted in suboptimal colistin concentrations. The necessity of a loading dose (LD) at treatment initiation has been proposed. A LD of 9 million IU (MU) [ca. 270 mg of colistin base activity (CBA)] was administrated with a maintenance dose of 4.5 MU (ca. 140 mg CBA) every 12 h (q12h) to eight critically ill patients receiving renal replacement therapy...
September 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27352068/hemodialysis-with-high-cut-off-hemodialyzers-in-patients-with-multi-drug-resistant-gram-negative-sepsis-and-acute-kidney-injury-a-retrospective-case-control-study
#6
Cosimo Chelazzi, Gianluca Villa, Maria Grazia D'Alfonso, Paola Mancinelli, Guglielmo Consales, Margherita Berardi, Angelo Raffaele De Gaudio, Stefano Romagnoli
BACKGROUND: Hemodialysis with high cut-off continuous veno-venous hemodialyzer (HCO-CVVHD) removes mediators of organ dysfunction during sepsis. This study assessed the clinical effects of HCO-CVVHD as compared to high-flux (HF) membranes during gram-negative sepsis. METHODS: Intensive care unit (ICU), septic patients treated with HCO-CVVHD or HF-CVVHDF for AKI were retrospectively observed (January 2013-December 2014). Mechanical ventilation, vasopressors' requirements, ICU length of stay (LOS) and ICU in-hospital mortality were compared between groups...
2016: Blood Purification
https://www.readbyqxmd.com/read/27338750/a-retrospective-review-of-fluid-balance-control-in-crrt
#7
Hugh Davies, Gavin D Leslie, David Morgan
INTRODUCTION: An effect of severe acute kidney injury (AKI) is the development of oliguria and subsequent retention of fluid. Recent studies have reported an association between fluid overload and increased mortality in critically ill patients. Achieving fluid balance control through haemofiltration is an important part of dialysis dose delivery in continuous renal replacement therapy (CRRT). AIMS: (1) Compare the prescribed dose with the delivered dose of dialysis and haemofiltration for CRRT...
June 20, 2016: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/27270279/influence-of-renal-replacement-modalities-on-amikacin-population-pharmacokinetics-in-critically-ill-patients-on-continuous-renal-replacement-therapy
#8
Claire Roger, Steven C Wallis, Laurent Muller, Gilbert Saissi, Jeffrey Lipman, Jean-Yves Lefrant, Jason A Roberts
The objective of this study was to describe amikacin pharmacokinetics (PK) in critically ill patients receiving equal doses (30 ml/kg of body weight/h) of continuous venovenous hemofiltration (CVVH) and continuous venovenous hemodiafiltration (CVVHDF). Patients receiving amikacin and undergoing CVVH or CVVHDF were eligible. Population pharmacokinetic analysis and Monte Carlo simulation were undertaken using the Pmetrics software package for R. Sixteen patients (9 undergoing CVVH, 11 undergoing CVVHDF) and 20 sampling intervals were analyzed...
August 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27176622/regional-citrate-versus-heparin-anticoagulation-for-continuous-renal-replacement-therapy-in-critically-ill-patients-a-meta-analysis-with-trial-sequential-analysis-of-randomized-controlled-trials
#9
Chao Liu, Zhi Mao, Hongjun Kang, Jie Hu, Feihu Zhou
BACKGROUND: Regional citrate or heparin is often prescribed as an anticoagulant for continuous renal replacement therapy (CRRT). However, their efficacy and safety remain controversial. Therefore, we performed this meta-analysis to compare these two agents and to determine whether the currently available evidence is sufficient and conclusive by using trial sequential analysis (TSA). METHODS: We searched for relevant studies in PubMed, Embase, the Cochrane Library databases and the China National Knowledge Infrastructure (CNKI) Database from database inception until September 2015...
May 13, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27126739/we-use-continuous-renal-replacement-therapy-for-overdoses-and-intoxications
#10
Valerie Jorge Cabrera, Anushree C Shirali
Extracorporeal modalities for the removal of drugs and toxins are indicated for the treatment of overdoses and intoxications. Well-established modalities include hemodialysis (HD), high-flux HD (HfD), and charcoal hemoperfusion (HP). Recently, there have been increasing reports on the use of continuous renal replacement therapy (CRRT), such as continuous veno-venous hemodialysis (CVVHD), continuous veno-venous hemofiltration (CVVH) or CVVH combined with dialysis (CVVHDF). In the present article, we will discuss the various factors that determine the clearance of drugs and toxins and accordingly, we will propose that with few exceptions, CRRT does not have a role in the routine management of intoxications...
July 2016: Seminars in Dialysis
https://www.readbyqxmd.com/read/27084247/high-dose-versus-conventional-dose-continuous-venovenous-hemodiafiltration-and-patient-and-kidney-survival-and-cytokine-removal-in-sepsis-associated-acute-kidney-injury-a-randomized-controlled-trial
#11
Jung Tak Park, Hajeong Lee, Youn Kyung Kee, Seokwoo Park, Hyung Jung Oh, Seung Hyeok Han, Kwon Wook Joo, Chun-Soo Lim, Yon Su Kim, Shin-Wook Kang, Tae-Hyun Yoo, Dong Ki Kim
BACKGROUND: Soluble inflammatory mediators are known to exacerbate sepsis-induced acute kidney injury (AKI). Continuous renal replacement therapy (CRRT) has been suggested to play a part in immunomodulation by cytokine removal. However, the effect of continuous venovenous hemodiafiltration (CVVHDF) dose on inflammatory cytokine removal and its influence on patient outcomes are not yet clear. STUDY DESIGN: Prospective, randomized, controlled, open-label trial. SETTING & PARTICIPANTS: Septic patients with AKI receiving CVVHDF for AKI...
October 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27070353/efficacy-of-two-combinations-of-blood-purification-techniques-for-the-treatment-of-multiple-organ-failure-induced-by-wasp-stings
#12
Hai Yuan, Shuangqin Chen, Fengqi Hu, Qi Zhang
BACKGROUND/AIMS: The aim of this study was to explore the clinical efficacy of 2 combinations of blood purification techniques in patients with sting venom-induced multiple organ dysfunction syndrome (MODS). METHODS: A total of 23 patients received 35 sessions of hemoperfusion (HP) + continuous veno-venous hemodiafiltration (CVVHDF) treatment and 22 sessions of plasma exchange (PE) + CVVHDF treatment, respectively. RESULTS: Both HP + CVVHDF and PE + CVVHDF reduced the levels of inflammation, thus improving our patients' health condition...
2016: Blood Purification
https://www.readbyqxmd.com/read/27051575/successful-treatment-of-a-carbapenem-resistant-klebsiella-pneumoniae-carrying-bla-oxa-48-bla-vim-2-bla-cmy-2-and-bla-shv-with-high-dose-combination-of-imipenem-and-amikacin
#13
Zied Hajjej, Hedi Gharsallah, Habiba Naija, Ilhem Boutiba, Iheb Labbene, Mustapha Ferjani
We describe a case of 58-year-old man with septic shock due to Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) bloodstream infections (BSI) who was successfully treated with a high dose association of amikacin and imipenem combined with continuous venovenous hemodiafiltration (CVVHDF). A Klebsiella pneumoniae (Kp) was isolated from the catheter culture and from two blood samples, drawn from the catheter before removal and from a peripheral vein. The Kp was intermediate to Amikacin (MIC = 16 μg/ml) and was resistant to all other antibiotics including Imipenem (MIC = 4 μg/ml), Colistin (MIC = 16 μg/ml) and Tigecycline (MIC = 4 μg/ml) according to the Clinical and Laboratory Standards Institute (CLSI) published in 2011...
2016: IDCases
https://www.readbyqxmd.com/read/27012450/ceftolozane-tazobactam-pharmacokinetics-in-a-critically-ill-adult-receiving-continuous-renal-replacement-therapy
#14
Derek N Bremmer, David P Nicolau, Pam Burcham, Anil Chunduri, Ganesh Shidham, Karri A Bauer
Limited data are available on ceftolozane/tazobactam dosing in patients receiving continuous renal replacement therapy (CRRT). Thus we performed a pharmacokinetic analysis of intravenous ceftolozane/tazobactam in a critically ill patient receiving CRRT at our medical center. A 47-year-old critically ill man with multidrug-resistant Pseudomonas aeruginosa pneumonia, bacteremia, and osteomyelitis was receiving ceftolozane/tazobactam 3 g (ceftolozane 2 g/tazobactam 1 g) every 8 hours while receiving continuous venovenous hemodiafiltration (CVVHDF)...
May 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/26998605/continuous-venovenous-hemodiafiltration-in-the-treatment-of-maple-syrup-urine-disease
#15
Demet Demirkol, Güntülü Şık, Nilüfer Topal, Agop Çıtak, Çigdem Zeybek, Abdülhamit Tüten, Ilmay Bilge
BACKGROUND: The study aims to define the efficacy of continuous renal replacement therapy in acute metabolic decompensation treatment of maple syrup urine disease (MSUD). METHODS: All the neonates, infants and children who have had life threatening conditions due to MSUD and were treated with continuous venovenous hemodiafiltration (CVVHDF) were analyzed retrospectively. RESULTS: Fourteen patients underwent 15 sessions of CVVHDF (age range 15 days to 87 months, mean 40...
2016: Blood Purification
https://www.readbyqxmd.com/read/26957490/comparison-of-equal-doses-of-continuous-venovenous-haemofiltration-and-haemodiafiltration-on-ciprofloxacin-population-pharmacokinetics-in-critically-ill-patients
#16
Claire Roger, Steven C Wallis, Benjamin Louart, Jean-Yves Lefrant, Jeffrey Lipman, Laurent Muller, Jason A Roberts
OBJECTIVES: Whilst commonly performed in ICUs, renal replacement therapies (RRTs) differ in their solute clearances. There is a paucity of data on ciprofloxacin clearances in different RRT techniques. The aim of this study was to compare the population pharmacokinetics of ciprofloxacin during equal doses of continuous venovenous haemofiltration (CVVHF) and continuous venovenous haemodiafiltration (CVVHDF) in septic patients. METHODS: Patients receiving 400 mg of ciprofloxacin intravenously 8 or 12 hourly and undergoing either CVVHF or CVVHDF were eligible...
June 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/26949936/electrolytes-enriched-hemodiafiltration-solutions-for-continuous-renal-replacement-therapy-in-acute-kidney-injury-a-crossover-study
#17
Noemie Besnard, Marianne Serveaux, Sonia Machado, Delphine Daubin, Vincent Brunot, Laurent Amigues, Liliane Landreau, Olivier Jonquet, Kada Klouche
AIMS: To evaluate the capability of an electrolytes-enriched solution to prevent metabolic disorders during continuous veno-venous hemodiafiltration (CVVHDF). METHODS: Serum biochemistry and clinical tolerance were compared during CVVHDF treatments with an electrolyte-enriched (Phoxilium) or standard solutions in 10 acute renal failure patients. RESULTS: As compared to standard fluids, serum potassium and phosphate levels were maintained in the normal range with Phoxilium without any supplementation but total serum calcium levels were significantly lower...
2016: Blood Purification
https://www.readbyqxmd.com/read/26881228/one-year-outcome-of-geriatric-hip-fracture-patients-following-prolonged-icu-treatment
#18
Daphne Eschbach, Christopher Bliemel, Ludwig Oberkircher, Rene Aigner, Juliana Hack, Benjamin Bockmann, Steffen Ruchholtz, Benjamin Buecking
PURPOSE: Incidence of geriatric fractures is increasing. Knowledge of outcome data for hip-fracture patients undergoing intensive-care unit (ICU) treatment, including invasive ventilatory management (IVM) and hemodiafiltration (CVVHDF), is sparse. METHODS: Single-center prospective observational study including 402 geriatric hip-fracture patients. Age, gender, the American Society of Anesthesiologists (ASA) classification, and the Barthel index (BI) were documented...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26871268/has-the-use-of-cvvhdf-when-compared-to-cvvh-during-crrt-affected-the-failed-circuit-life-within-a-major-teaching-hospital-a-service-evaluation
#19
Jody Ede, Andrea Dale
BACKGROUND: A significant problem during continuous renal replacement therapy is premature circuit failure, affecting efficacy and molecular clearance. Techniques to improve circuit failure are anticoagulation, access site and modality. A modality change was introduced, moving from continuous veno-venous haemofiltration to continuous veno-venous haemodiafiltration as a result of existing issues with failing circuit times and failure rates. AIM: The aim of this service evaluation was to ascertain if the use of continuous veno-venous haemodiafiltration compared to continuous veno-venous haemofiltration had affected failed circuit survival times and rates...
February 12, 2016: Nursing in Critical Care
https://www.readbyqxmd.com/read/26869692/piperacillin-population-pharmacokinetics-in-critically-ill-patients-with-multiple-organ-dysfunction-syndrome-receiving-continuous-venovenous-haemodiafiltration-effect-of-type-of-dialysis-membrane-on-dosing-requirements
#20
Marta Ulldemolins, Ignacio Martín-Loeches, Mireia Llauradó-Serra, Javier Fernández, Sergi Vaquer, Alejandro Rodríguez, Caridad Pontes, Gonzalo Calvo, Antoni Torres, Dolors Soy
OBJECTIVES: This multicentre study aimed to describe the pharmacokinetics (PK) of piperacillin in critically ill patients with multiple organ dysfunction syndrome (MODS) receiving continuous venovenous haemodiafiltration (CVVHDF), to identify the sources of PK variability and evaluate different dosing regimens to develop recommendations based on clinical parameters. PATIENTS AND METHODS: Nineteen patients with MODS and CVVHDF receiving piperacillin/tazobactam were enrolled from three tertiary hospitals (95 plasma samples)...
June 2016: Journal of Antimicrobial Chemotherapy
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