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https://www.readbyqxmd.com/read/29679782/outcomes-after-off-label-use-of-the-pipeline-embolization-device-for-intracranial-aneurysms-a-multicenter-cohort-study
#1
S G Zammar, T J Buell, C J Chen, R W Crowley, D Ding, C J Griessenauer, B L Hoh, K C Liu, C S Ogilvy, Raper, A Singla, A J Thomas, K M Cockroft, S D Simon
OBJECTIVES: The aim of this retrospective multicenter cohort study is to examine the outcomes of the Pipeline embolization device (PED) for the treatment of intracranial aneurysms outside of United States Food and Drug Administration approved (off-label) indications. METHODS: Data from aneurysm patients treated with the PED for off-label indications was pooled from four different centers. The primary endpoints were decline in modified Rankin Scale (mRS) by at least 1 point and angiographic aneurysm occlusion at follow-up...
April 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678967/development-and-evaluation-of-an-algorithm-based-tool-for-medication-management-in-nursing-homes-the-amber-study-protocol
#2
Susanne Erzkamp, Olaf Rose
BACKGROUND: Residents of nursing homes are susceptible to risks from medication. Medication Reviews (MR) can increase clinical outcomes and the quality of medication therapy. Limited resources and barriers between healthcare practitioners are potential obstructions to performing MR in nursing homes. Focusing on frequent and relevant problems can support pharmacists in the provision of pharmaceutical care services. This study aims to develop and evaluate an algorithm-based tool that facilitates the provision of Medication Management in clinical practice...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678248/influence-of-immediate-dentin-sealing-and-interim-cementation-on-the-adhesion-of-indirect-restorations-with-dual-polymerizing-resin-cement
#3
Nallu G L Hironaka, Adriana L M Ubaldini, Francielle Sato, Marcelo Giannini, Raquel S S Terada, Renata C Pascotto
STATEMENT OF PROBLEM: Dentin surface contamination before the cementation of indirect restorations may impact bonding effectiveness. PURPOSE: The purpose of this in vitro study was to analyze the influence of immediate dentin sealing (IDS) and interim cementation on the adhesion of indirect restorations with a dual-polymerizing resin cement. MATERIAL AND METHODS: Composite resin inlays were placed in class V cavities prepared in the buccal and lingual surfaces of 30 extracted human molars with a dual-polymerizing resin cement in 3 different ways (n=10): CG, directly on dentin; PG, after 14 days interim cementation; SG, after IDS and 14 days interim cementation...
April 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29678171/analysis-of-hepatic-transcriptome-demonstrates-altered-lipid-metabolism-following-lactobacillus-johnsonii-bs15-prevention-in-chickens-with-subclinical-necrotic-enteritis
#4
Xiaodan Qing, Dong Zeng, Hesong Wang, Xueqin Ni, Jing Lai, Lei Liu, Abdul Khalique, Kangcheng Pan, Bo Jing
BACKGROUND: Subclinical necrotic enteritis (SNE) widely outbreaks in chickens which inflicted growth-slowing, causing enormous social and economic burdens. To better understand the molecular underpinnings of SNE on lipid metabolism and explore novel preventative strategies against SNE, we studied the regulatory mechanism of a potential probiotic, Lactobacillus johnsonii BS15 on the lipid metabolism pathways involved in chickens with SNE. METHODS: One hundred eighty one-day-old chickens were randomly divided into three groups and arranged with basal diet (control and SNE group)...
April 20, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29676694/keyhole-strategy-aiming-at-minimizing-hospital-stay-for-surgical-clipping-of-unruptured-middle-cerebral-artery-aneurysms
#5
Kentaro Mori, Kojiro Wada, Naoki Otani, Arata Tomiyama, Terushige Toyooka, Satoru Takeuchi, Takuji Yamamoto, Yasuaki Nakao, Hajime Arai
OBJECTIVE Aneurysms of the middle cerebral artery (MCA) are still most often treated by clipping through standard craniotomy, but a longer hospital stay is one of the main drawbacks of this treatment. The authors developed a pterional keyhole clipping strategy for unruptured MCA aneurysms with the intention of minimizing hospital stay. In this paper, they report on their experience with this approach and analyze the long-term neurological and radiological outcomes. METHODS A total of 160 relatively small unruptured MCA aneurysms (mean 6...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676516/the-pea-leafminer-liriomyza-huidobrensis-diptera-agromyzidae-uses-the-vibrational-duets-for-efficient-sexual-communication
#6
Jin Ge, Jia-Ning Wei, Ding-Jie Zhang, Chun Hu, De-Zhi Zheng, Le Kang
The pea leafminer (Liriomyza huidobrensis) is a notorious pest of vegetables and ornamental plants worldwide. Despite a large number of studies on its biology and ecology, the courtship behavior and sexual communication of this species remain unclear. Here, we studied the vibrational communication in the sexual interaction of the pea leafminer. On host plant leaves, females and males behaviorally displayed the bobbing-quivering alternation, which finally led to copulation. Moreover, records of laser vibrometry revealed three-signal duets underlying the behavioral alternation...
April 20, 2018: Insect Science
https://www.readbyqxmd.com/read/29676403/combined-endoscopic-transorbital-and-endonasal-repair-of-high-flow-orbital-apex-middle-fossa-cerebrospinal-fluid-leak-with-a-nasoseptal-flap
#7
Brandon Lucke-Wold, Gustavo Mendez, David Cua, Paul Akins, Haley Gillham, Jeremy Ciporen
Background and importance: High flow orbital apex or middle fossa cerebrospinal fluid (CSF) leaks can be life threatening and complex to repair. These leaks associated with large dural defects are most commonly repaired with an open temporalis muscle patch or free flaps, but these flaps do not always stop the leak. Clinical Presentation: A 65-year-old patient presented two years after orbital exenteration and radiation for squamous cell carcinoma. He developed multi-organism meningitis and pneumocephalus secondary to a large high-flow orbital apex/middle fossa CSF leak...
2018: Journal of neuroinflammation and neurodegenerative diseases
https://www.readbyqxmd.com/read/29676224/20-year-trends-of-characteristics-and-outcomes-of-stroke-patients-with-atrial-fibrillation
#8
George Ntaios, Dimitrios Sagris, Fotios Gioulekas, Petros Galanis, Christianna Pardali, Anastasia Vemmou, Eleni Koroboki, Vasileios Papavasileiou, Sofia Vassilopoulou, Efstathios Manios, Konstantinos Makaritsis, Konstantinos Spengos, Dimos-Dimitrios Mitsikostas, Haralambos Milionis, Konstantinos Vemmos
Background The accurate knowledge of secular trends in prevalence, characteristics and outcomes of patients with ischemic stroke and atrial fibrillation allows better projections into the future. Aim We aimed to report the overall, age- and sex-specific secular trends of characteristics and outcomes of patients with acute ischemic stroke (AIS) and atrial fibrillation between 1993 and 2012 in the Athens Stroke Registry. Methods We used Joinpoint regression analysis to calculate the average annual percent changes and 95% confidence intervals...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29675098/baseline-metabolic-risk-score-and-postsurgical-esophageal-cancer-specific-mortality-the-fujian-prospective-investigation-of-cancer-fiesta-study
#9
Hong Sha, Dan Hu, Sinan Wu, Feng Peng, Guodong Xu, Guohui Fan, Xiandong Lin, Gang Chen, Binying Liang, Ying Chen, Chao Li, Hejun Zhang, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu
Backgrounds : Compelling evidence has emerged to support a close relationship between metabolic syndrome and esophageal cancer (EC). Aims : Using five baseline metabolism-related markers, we constructed a metabolic risk score (MRS), aiming to test whether MRS can improve the prediction of postsurgical EC-specific mortality over traditional demographic and clinicopathologic characteristics. Methods : Total 2535 EC patients who received three-field lymphadenectomy were enrolled from January 2000 to December 2010, and they were followed up until December 2015...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29674417/value-of-quantitative-collateral-scoring-on-ct-angiography-in-patients-with-acute-ischemic-stroke
#10
A M M Boers, R Sales Barros, I G H Jansen, O A Berkhemer, L F M Beenen, B K Menon, D W J Dippel, A van der Lugt, W H van Zwam, Y B W E M Roos, R J van Oostenbrugge, C H Slump, C B L M Majoie, H A Marquering
BACKGROUND AND PURPOSE: Many studies have emphasized the relevance of collateral flow in patients presenting with acute ischemic stroke. Our aim was to evaluate the relationship of the quantitative collateral score on baseline CTA with the outcome of patients with acute ischemic stroke and test whether the timing of the CTA acquisition influences this relationship. MATERIALS AND METHODS: From the Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands (MR CLEAN) data base, all baseline thin-slice CTA images of patients with acute ischemic stroke with intracranial large-vessel occlusion were retrospectively collected...
April 19, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29673834/severity-and-duration-of-menopausal-symptoms-after-risk-reducing-salpingo-oophorectomy
#11
A Stuursma, C M G van Driel, N J Wessels, G H de Bock, M J E Mourits
OBJECTIVES: To reduce the risk of ovarian cancer, women with BRCA1/2 mutations are advised to undergo risk-reducing salpingo-oophorectomy (RRSO) at a premenopausal age. Premenopausal RRSO results in acute menopause and is associated with various menopausal symptoms. This study investigates the severity and duration of subjective menopausal symptoms after premenopausal RRSO and associated factors. METHODS: We included 199 women who had undergone RRSO before age 52 in this cross-sectional study...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29673828/decision-making-for-the-treatment-of-climacteric-symptoms-using-the-menopause-rating-scale
#12
Juan Enrique Blümel, Eugenio Arteaga, Joaquín Parra, Carolina Monsalve, Valentina Reyes, María Soledad Vallejo, Rosa Chea
OBJECTIVE: The Menopause Rating Scale (MRS) is one of the most frequently used instruments to evaluate menopausal symptoms; however, no cut-off score is given that would indicate the need for treatment. Our goal was to determine such a cut-off score on the MRS, using as a standard a woman's own perception of her need for treatment in relation to the severity of her symptoms. MATERIAL AND METHODS: The sample comprised 427 healthy women aged 40-59 years who were not taking hormonal treatment...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29673817/combined-outcomes-of-endovascular-or-surgical-treatment-of-unruptured-anterior-communicating-artery-aneurysms-is-a-more-aggressive-management-strategy-warranted
#13
Philip G R Schmalz, Alejandro Enriquez-Marulanda, Abdulrahman Alturki, Christopher J Stapleton, Ajith J Thomas, Christopher S Ogilvy
BACKGROUND: Updated natural history studies suggest anterior communicating artery aneurysms have a higher risk of rupture than formerly appreciated. As endovascular and open techniques advance, morbidity may fall to levels which suggest intervention even for small aneurysms. OBJECTIVE: Assess treatment risk for smaller, unruptured anterior communicating artery aneurysms. METHODS: A cross-sectional study of 149 patients with unruptured anterior communicating aneurysms treated over a six-year period was performed...
April 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29672312/impact-of-brain-atrophy-on-early-neurological-deterioration-and-outcome-in-severe-ischemic-stroke-treated-by-intravenous-thrombolysis
#14
Olivier Tschirret, Gabriela Moreno Legast, Adeline Mansuy, Nathan Mewton, Marielle Buisson, Salem Hannoun, Leila Chamard, Dominique Sappey-Marinier, Carlos El Khoury, Magali Bischoff, Audrey de Parisot, Laurent Derex, Norbert Nighoghossian, Yves Berthezène, Laura Mechtouff
BACKGROUND: Brain atrophy has shown a protective effect on the risk of early neurological deterioration (END) related to malignant edema in patients with hemispheric infarction but could be deleterious on the outcome. AIMS: We aimed to assess whether brain atrophy has an impact on the risk of END and on the outcome in severe ischemic strokes after intravenous (IV) thrombolysis. METHODS: From a prospective thrombolysis registry, 137 patients who had a National Institutes of Health Stroke Scale (NIHSS) ≥15, MRI at admission, and IV thrombolysis were included...
April 19, 2018: European Neurology
https://www.readbyqxmd.com/read/29672289/prominent-hypointense-vessel-sign-on-susceptibility-weighted-imaging-is-associated-with-clinical-outcome-in-acute-ischaemic-stroke
#15
Yiqi Wang, Tianming Shi, Bo Chen, Gaoping Lin, Yuyun Xu, Yu Geng
BACKGROUND: Prominent hypointense vessel sign (PHVS) is visualized on susceptibility weighted-imaging (SWI) in acute ischaemic stroke (AIS). We aim to test if PHVS is associated with stroke outcome. METHODS: Forty patients with acute middle cerebral artery occlusion were recruited. The presence of PHVS, cortical vessel sign (CVS), brush sign (BS) and susceptibility-diffuse weighted imaging mismatch (S-D mismatch) and Alberta Stroke Program Early CT Score (ASPECTS) on SWI were compared between the good outcome group (90-day modified Rankin scale [mRS] of 0-2) and the poor outcome group (mRS of 3-6)...
April 19, 2018: European Neurology
https://www.readbyqxmd.com/read/29672166/the-effect-of-leech-extracts-on-endothelial-cell-coagulation-related-factors-and-endothelial-dysfuction-related-molecules
#16
Lixu Xu, Xue Li, E Zhang, Hao Liang, Weiting Li, Shangyi Wang, Shuliang Song, Aiguo Ji
OBJECTIVE: This study was focused on screening leech extracts to identify those with little or no anti-coagulation effect or with significant anti-endothelial dysfunction activity. METHODS: Different leech extracts were prepared by enzymolysis and microbial transformation and their cytotoxicity were measured by MTT assay. The effect of different leech extracts on mRNA expression of coagulation-related factors (PAI, vWF, tPA, PS, TFPI, TM) was quantified by RT-PCR...
April 19, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29671291/do-antiplatelet-and-anticoagulant-drugs-modify-outcome-of-patients-treated-for-chronic-subdural-hematoma-still-a-controversial-issue
#17
Alba Scerrati, Annunziato Mangiola, Francesco Rigoni, Simone Olei, Mariaconsiglia Santantonio, Gianluca Trevisi, Carmelo Anile, Michele A Cavallo, Pasquale De Bonis
BACKGROUND: Anticoagulants(ACs) and antiplatelet aggregation agents(AAAs) seem to be correlated to a higher incidence of chronic subdural hematoma(CSDH) but whether or not they contribute to its recurrence is debated. Few data are available on clinical outcomes and indications for the management of this therapy are not so well defined. We investigated the role of ACs and AAAs in modifying patients clinical outcomes treated for CSDH, especially for re-bleedings. METHODS: This retrospective study, enrolled patients treated for CSDH...
April 18, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29670570/mexican-national-institute-of-neurology-and-neurosurgery-stroke-registry-results-of-a-25-year-hospital-based-study
#18
Antonio Arauz, Juan Manuel Marquez-Romero, Miguel A Barboza, Fabiola Serrano, Carol Artigas, Luis Manuel Murillo-Bonilla, Carlos Cantú-Brito, José Luis Ruiz-Sandoval, Fernando Barinagarrementeria
Background and purpose: Stroke has been scarcely studied in Latin America (LA). The Mexican Institute of Neurology Stroke Registry was established in 1990 as a prospective computer-based database to register data obtained from patients admitted with stroke. Using this data, we attempted to define the profile of risk factors and outcomes. Methods: The demographic data, stroke description, ancillary tests, vascular risk factors, and modified Rankin scale (mRs) were registered...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29670177/proton-decoupled-carbon-magnetic-resonance-spectroscopy-in-human-calf-muscles-at-7-t-using-a-multi-channel-radiofrequency-coil
#19
Sigrun Goluch, Roberta Frass-Kriegl, Martin Meyerspeer, Michael Pichler, Jürgen Sieg, Martin Gajdošík, Martin Krššák, Elmar Laistler
13 C magnetic resonance spectroscopy is a viable, non-invasive method to study cell metabolism in skeletal muscles. However, MR sensitivity of 13 C is inherently low, which can be overcome by applying a higher static magnetic field strength together with radiofrequency coil arrays instead of single loop coils or large volume coils, and 1 H decoupling, which leads to a simplified spectral pattern. 1 H-decoupled 13 C-MRS requires RF coils which support both, 1 H and 13 C, Larmor frequencies with sufficient electromagnetic isolation between the pathways of the two frequencies...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29670128/mitochondrial-function-in-individuals-at-clinical-high-risk-for-psychosis
#20
Tania Da Silva, Abbie Wu, Isabelle Laksono, Ivana Prce, Margaret Maheandiran, Michael Kiang, Ana C Andreazza, Romina Mizrahi
Alterations in mitochondrial function have been implicated in the etiology of schizophrenia. Most studies have investigated alterations in mitochondrial function in patients in which the disorder is already established; however, whether mitochondrial dysfunction predates the onset of psychosis remains unknown. We measured peripheral mitochondrial complex (I-V) function and lactate/pyruvate levels in 27 antipsychotic-naïve individuals at clinical high risk for psychosis (CHR) and 16 healthy controls. We also explored the association between mitochondrial function and brain microglial activation and glutathione levels using a translocator protein 18 kDa [18 F]FEPPA PET scan and 1 H-MRS scan, respectively...
April 18, 2018: Scientific Reports
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