keyword
MENU ▼
Read by QxMD icon Read
search

MRS

keyword
https://www.readbyqxmd.com/read/29917080/association-between-cortical-gaba-and-loudness-dependence-of-auditory-evoked-potentials-ldaep-in-humans
#1
Christine Wyss, Desmond H Y Tse, Frank Boers, Jon Shah N, Irene Neuner, Wolfram Kawohl
Loudness dependence of auditory evoked potentials (LDAEP) is a widely used electroencephalography (EEG) based biomarker for central serotonergic activity. Serotonin has been shown to be associated with different psychiatric disorders such as depression and schizophrenia. Despite its clinical significance, the underlying neurochemical mechanism of this promising marker is not fully understood and further research is needed to improve its validity. Other neurotransmitters might have a significant impact on this measure...
June 15, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29916084/effects-of-sildenafil-and-calcitonin-gene-related-peptide-on-brainstem-glutamate-levels-a-pharmacological-proton-magnetic-resonance-spectroscopy-study-at-3-0-t
#2
Samaira Younis, Anders Hougaard, Casper Emil Christensen, Mark Bitsch Vestergaard, Esben Thade Petersen, Olaf Bjarne Paulson, Henrik Bo Wiberg Larsson, Messoud Ashina
BACKGROUND: Studies involving human pharmacological migraine models have predominantly focused on the vasoactive effects of headache-inducing drugs, including sildenafil and calcitonin gene-related peptide (CGRP). However, the role of possible glutamate level changes in the brainstem and thalamus is of emerging interest in the field of migraine research bringing forth the need for a novel, validated method to study the biochemical effects in these areas. METHODS: We applied an optimized in vivo human pharmacological proton (1 H) magnetic resonance spectroscopy (MRS) protocol (PRESS, repetition time 3000 ms, echo time 37...
June 18, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29914129/obesity-related-metabolic-risk-in-sedentary-hispanic-adolescent-girls-with-normal-bmi
#3
Gert-Jan van der Heijden, Zhiyue J Wang, Zili D Chu, Morey Haymond, Pieter J J Sauer, Agneta L Sunehag
Hispanic adolescent girls with normal BMI frequently have high body fat %. Without knowledge of body fat content and distribution, their risk for metabolic complications is unknown. We measured metabolic risk indicators and abdominal fat distribution in post-pubertal Hispanic adolescent girls with Normal BMI (N-BMI: BMI < 85th percentile) and compared these indicators between girls with Normal BMI and High Fat content (N-BMI-HF: body fat &ge; 27%; n = 15) and Normal BMI and Normal Fat content (N-BMI-NF: body fat < 27%; n = 8)...
June 15, 2018: Children
https://www.readbyqxmd.com/read/29912445/anterior-cingulate-glutamate-and-gaba-associations-on-functional-connectivity-in-schizophrenia
#4
Dinesh K Shukla, S Andrea Wijtenburg, Hongji Chen, Joshua J Chiappelli, Peter Kochunov, L Elliot Hong, Laura M Rowland
Background: The underlying neurobiological mechanism for abnormal functional connectivity in schizophrenia (SCZ) remains unknown. This project investigated whether glutamate and GABA, 2 metabolites that contribute to excitatory and inhibitory functions, may influence functional connectivity in SCZ. Methods: Resting-state functional magnetic resonance imaging and proton magnetic resonance spectroscopy were acquired from 58 SCZ patients and 61 healthy controls (HC)...
June 15, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29911203/automated-voxel-placement-a-linux-based-suite-of-tools-for-accurate-and-reliable-single-voxel-coregistration
#5
Eric A Woodcock, Muzamil Arshad, Dalal Khatib, Jeffrey A Stanley
Background: Single-voxel proton magnetic resonance spectroscopy (1 H MRS) is a powerful technique for studying in vivo neurochemistry, but has an often-overlooked source of error variance: inconsistent voxel placement between scans. We developed and evaluated an Automated Voxel Placement (AVP) procedure for accurate and reliable 1 H MRS voxel prescription. AVP is a suite of Linux-based programs that facilitate automated template-driven single-voxel coregistration. Methods: Three studies were conducted to evaluate AVP for prescription of one voxel: left dorsolateral prefrontal cortex...
2018: Journal of Neuroimaging in Psychiatry & Neurology
https://www.readbyqxmd.com/read/29911072/inhibiting-glycine-decarboxylase-suppresses-pyruvate-to-lactate-metabolism-in-lung-cancer-cells
#6
Chern Chiuh Woo, Kavita Kaur, Wei Xin Chan, Xing Qi Teo, Teck Hock Philip Lee
Glycine decarboxylase (GLDC) gene is frequently upregulated in various types of cancer including lung, prostate and brain. It catabolizes glycine to yield 5,10-methylenetetrahydrofolate, an important substrate in one-carbon metabolism for nucleotide synthesis. In this study, we used exon splicing modulating steric hindrance antisense oligonucleotide (shAON) to suppress GLDC expression and investigated its effect on pyruvate metabolism via hyperpolarized carbon-13 magnetic resonance spectroscopy (MRS). The MRS technique allows us to study in vivo metabolic flux in tumor tissues with/without GLDC-shAON intervention...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29909213/pipeline-embolization-device-flow-diversion-for-a-dissecting-ruptured-posterior-cerebral-artery-aneurysm-in-a-pediatric-patient
#7
Murillo Cunegatto-Braga, Brian Hogan, Pedro Aguilar-Salinas, Alexandra D Beier, Ricardo A Hanel
BACKGROUND: Intracranial aneurysms(IAs) are rare in the pediatric population and are usually considered difficult to treat with traditional microsurgery due to their complex morphology. Endovascular techniques have become the standard option for treating IAs in adults. More recently, flow diverters such as the Pipeline Embolization Device(PED) are being widely adopted for unruptured IAs with safety and efficacy in adults, yet their use in the pediatric population is not well defined. In this paper we present a pediatric patient with a ruptured PCA aneurysm successfully treated with a PED and a review of the literature of the current status of PED use in this subset of patients...
June 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29908306/listeria-monocytogenes-and-salmonella-enterica-affect-the-expression-of-nisin-gene-and-its-production-by-lactococcus-lactis
#8
Soosan Abdollahi, Mohammad Hossein Ghahremani, Neda Setayesh, Nasrin Samadi
The Lactococcus lactis is known as a probiotic bacterium and also as a producer of nisin. Nisin has been approved by related legal agencies to be used as an antimicrobial peptide in food preservation. In fact, the L. lactis is present in different food products along with other micro-organisms especially pathogenic bacteria. So, it is important to predict the behavior of nisin-producer strain in contact with other pathogens. In this regard, nisin gene expression and the level of secreted biologically active form of nisin by L...
June 13, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29907947/introduction-of-direct-oral-anticoagulant-within-7-days-of-stroke-onset-a-nomogram-to-predict-the-probability-of-3-month-modified-rankin-scale-score-2
#9
Manuel Cappellari, Gianni Turcato, Stefano Forlivesi, Nicola Micheletti, Giampaolo Tomelleri, Bruno Bonetti, Giovanni Merlino, Roberto Eleopra, Monia Russo, Roberto L'Erario, Alessandro Adami, Carolina Gentile, Anna Gaudenzi, Sandro Bruno, Paolo Bovi
In clinical practice, direct oral anticoagulants (DOACs) are often started earlier (≤ 7 days) than in randomized clinical trials after stroke. We aimed to develop a nomogram model incorporating time of DOAC introduction ≤ 7 days of stroke onset in combination with different degrees of stroke radiological/neurological severity at the time of treatment to predict the probability of unfavorable outcome. We conducted a multicenter prospective study including 344 patients who started DOAC 1-7 days after atrial fibrillation-related stroke onset...
June 15, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29907927/-1-h-mrs-spectroscopy-in-preclinical-autosomal-dominant-alzheimer-disease
#10
Elizabeth Joe, Luis D Medina, John M Ringman, Joseph O'Neill
1 H magnetic resonance spectroscopy (MRS) can reveal changes in brain biochemistry in vivo in humans and has been applied to late onset Alzheimer disease (AD). Carriers of mutations for autosomal dominant Alzheimer disease (ADAD) may show changes in levels of metabolites prior to the onset of clinical symptoms. Proton MR spectra were acquired at 1.5 T for 16 cognitively asymptomatic or mildly symptomatic mutation carriers (CDR < 1) and 11 non-carriers as part of a comprehensive cross-sectional study of preclinical ADAD...
June 16, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29903395/incidence-prognosis-and-prediction-of-haemorrhagic-transformation-after-revascularisation-for-stroke
#11
P B García Jurado, E Roldán Romero, M E Pérez Montilla, R Valverde Moyano, I M Bravo Rey, F Delgado Acosta, F A Bravo-Rodríguez
INTRODUCTION: Haemorrhagic transformation is a major complication of acute ischaemic stroke (AIS). We sought to determine the predictors and clinical impact of intracranial haemorrhage (ICH) after revascularisation therapy. METHODS: We conducted a retrospective, single-centre study including 235 patients with AIS who underwent intravenous recombinant tissue plasminogen activator (IV-rtPA) therapy and/or endovascular treatment. A binary logistic regression model was used to determine the variables associated with ICH, parenchymal haematomas (PH), modified Rankin Scale (mRS) scores, and mortality...
June 11, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29902200/acrin-6684-multicenter-phase-ii-assessment-of-tumor-hypoxia-in-newly-diagnosed-glioblastoma-using-magnetic-resonance-spectroscopy
#12
Eva-Maria Ratai, Zheng Zhang, James Fink, Mark Muzi, Lucy Hanna, Erin Greco, Todd Richards, Daniel Kim, Ovidiu C Andronesi, Akiva Mintz, Lale Kostakoglu, Melissa Prah, Benjamin Ellingson, Kathleen Schmainda, Gregory Sorensen, Daniel Barboriak, David Mankoff, Elizabeth R Gerstner
A multi-center imaging trial by the American College of Radiology Imaging Network (ACRIN) "A Multicenter, phase II assessment of tumor hypoxia in glioblastoma using 18F Fluoromisonidazole (FMISO) with PET and MRI (ACRIN 6684)", was conducted to assess hypoxia in patients with glioblastoma (GBM). The aims of this study were to support the role of proton magnetic resonance spectroscopic imaging (1H MRSI) as a prognostic marker for brain tumor patients in multi-center clinical trials. Seventeen participants from four sites had analyzable 3D MRSI datasets acquired on Philips, GE or Siemens scanners at either 1...
2018: PloS One
https://www.readbyqxmd.com/read/29900414/development-and-validation-of-the-dutch-stroke-score-for-predicting-disability-and-functional-outcome-after-ischemic-stroke-a-tool-to-support-efficient-discharge-planning
#13
Inger R de Ridder, Simone A Dijkland, Maaike Scheele, Heleen M den Hertog, Maaike Dirks, Willeke F Westendorp, Paul J Nederkoorn, Diederik van de Beek, Gerard M Ribbers, Ewout W Steyerberg, Hester F Lingsma, Diederik Wj Dippel
Introduction: We aimed to develop and validate a prognostic score for disability at discharge and functional outcome at three months in patients with acute ischemic stroke based on clinical information available on admission. Patients and methods: The Dutch Stroke Score (DSS) was developed in 1227 patients with ischemic stroke included in the Paracetamol (Acetaminophen) In Stroke study. Predictors for Barthel Index (BI) at discharge ('DSS-discharge') and modified Rankin Scale (mRS) at three months ('DSS-3 months') were identified in multivariable ordinal regression...
June 2018: European stroke journal
https://www.readbyqxmd.com/read/29900411/the-effect-of-different-combinations-of-vascular-dependency-and-cognitive-endpoints-on-the-sample-size-required-to-detect-a-treatment-effect-in-trials-of-treatments-to-improve-outcome-after-lacunar-and-non-lacunar-ischaemic-stroke
#14
Stephen Dj Makin, Fergus N Doubal, Terence J Quinn, Philip Mw Bath, Martin S Dennis, Joanna M Wardlaw
Background: Endpoints that are commonly used in trials of moderate/severe stroke may be less frequent in patients with minor, non-disabling stroke thus inflating sample sizes. We tested whether trial efficiency might be improved with composite endpoints. Methods: We prospectively recruited patients with lacunar and minor non-lacunar ischaemic stroke (NIHSS ≤ 7) and assessed recurrent vascular events (stroke, transient ischaemic attack (TIA), ischemic heart disease (IHD)), modified Rankin Score (mRS) and cognitive testing with the Addenbrooke's Cognitive Examination (ACE-R) one year post-stroke...
March 2018: European stroke journal
https://www.readbyqxmd.com/read/29899773/phenylketonuria-our-experience-in-nine-years-at-a-tertiary-level-referral-institute
#15
Sadanandvalli R Chandra, Rita Christopher, Mane M Daryappa, Rashmi Devaraj
Introduction: Phenyl ketonuria is an inborn error of amino acid metabolism resulting in excessive phenyl alanine levels in blood resulting in a spectrum of neurological defects. Patients and Methods: We retrospectively went through the records of patients diagnosed as Phenyl ketonuria in the last nine years in our team and patients who's data could be accessed were analyzed in detail. Details of laboratory tests, imaging clinical features, course were recorded. Observation: A total of 32 patients were identified in nine years of which data was available only for 15 patients...
January 2018: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29898739/longitudinal-chemokine-profile-expression-in-a-blood-brain-barrier-model-from-alzheimer-transgenic-versus-wild-type-mice
#16
J Vérité, T Janet, D Chassaing, B Fauconneau, H Rabeony, G Page
BACKGROUND: Alzheimer's disease is widely described since the discovery of histopathological lesions in Mrs. Auguste Deter in 1906. However to date, there is no effective treatment to deal with the many cellular and molecular alterations. The complexity is even higher with the growing evidence of involvement of the peripheral blood mononuclear cells (PBMCs). Indeed, monocytes and T cells are shown in the cerebral parenchyma of AD patients, and these cells grafted to the periphery are able to go through the blood-brain barrier (BBB) in transgenic mouse models...
June 13, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29898080/rescue-therapy-with-stent-retrievers-for-thromboembolism-during-endovascular-treatment-of-intracranial-aneurysms
#17
Zeferino Demartini Junior, Luana A Maranha Gatto, Gelson Luis Koppe, Tatiana F von Hertwig de Oliveira, Alexandre Novicki Francisco
Thromboembolism is the most frequent complication in endovascular treatment of intracranial aneurysms, causing disability and death. As stent retrievers have achieved high rates of arterial recanalization in the management of ischemic stroke, these devices were tested as rescue therapy of thromboembolism during aneurysm embolization. We retrospectively analyzed 10 consecutive patients with transprocedural arterial occlusion, treated with mechanical thrombectomy at a single center. Good angiographic recanalization was achieved in eight cases, mTICI 3, 2b and 2a in five, three and two patients, respectively, without additional complications or any deaths...
May 2018: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29896087/changes-of-visual-pathway-and-brain-connectivity-in-glaucoma-a-systematic-review
#18
Raffaele Nuzzi, Laura Dallorto, Teresa Rolle
Background: Glaucoma is a leading cause of irreversible blindness worldwide. The increasing interest in the involvement of the cortical visual pathway in glaucomatous patients is due to the implications in recent therapies, such as neuroprotection and neuroregeneration. Objective: In this review, we outline the current understanding of brain structural, functional, and metabolic changes detected with the modern techniques of neuroimaging in glaucomatous subjects. Methods: We screened MEDLINE, EMBASE, CINAHL, CENTRAL, LILACS, Trip Database, and NICE for original contributions published until 31 October 2017...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29894935/a-new-high-performance-thin-layer-chromatographic-method-for-determining-bile-salt-hydrolase-activity
#19
Nur Syakila Rohawi, Kalavathy Ramasamy, Snezana Agatonovic-Kustrin, Siong Meng Lim
A quantitative assay using high-performance thin-layer chromatography (HPTLC) was developed to investigate bile salt hydrolase (BSH) activity in Pediococcus pentosaceus LAB6 and Lactobacillus plantarum LAB12 probiotic bacteria isolated from Malaysian fermented food. Lactic acid bacteria (LAB) were cultured in de Man Rogosa and Sharpe (MRS) broth containing 1 mmol/L of sodium-based glyco- and tauro-conjugated bile salts for 24 h. The cultures were centrifuged and the resultant cell free supernatant was subjected to chromatographic separation on a HPTLC plate...
June 5, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29890540/rehabilitation-after-clipping-of-cerebral-aneurysms-without-acute-subarachnoid-hemorrhage-outcome-analysis-of-100-consecutive-cases
#20
Andreas Jödicke, Karsten Bauer, Andrea Hajdukova
BACKGROUND:  Discharge to rehabilitation is reported in large studies as one important outcome parameter based on hospital codes. Because neurologic outcome scores (e.g., the modified Rankin Scale [mRS]) are missing in International Classification of Diseases (ICD) databases, rehabilitation indirectly serves as a kind of surrogate parameter for overall outcome. Reported fractions of patients with rehabilitation, however, largely differ between studies and seem high for patients with aneurysm clipping...
June 11, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
keyword
keyword
15788
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"