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https://www.readbyqxmd.com/read/29458185/tiny-cerebral-aneurysms-can-be-safely-and-effectively-treated-with-lvis-stent-assisted-coiling-or-coiling-alone
#1
Bu-Lang Gao, Tian-Xiao Li, Li Li, Gang-Qin Xu, Bo-Wen Yang
BACKGROUND: The effect and safety of LVIS stent-coiling is currently not known for treating tiny intracranial aneurysms. OBJECTIVE: To investigate the effect and safety of LVIS stent-assisted coiling and coiling alone in treating patients with mostly ruptured tiny aneurysms. METHODS: Seventy-five patients with tiny intracranial aneurysms including 63 ruptured ones were treated endovascularly and analyzed. RESULTS: In the coiling group, complete occlusion was achieved in 35 patients (83...
February 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29458183/age-dependent-attitudes-of-ischemic-patients-towards-disability-after-decompressive-hemicraniectomy-for-malignant-middle-cerebral-artery-infarction
#2
Byoung-Joon Kim, Yeon Ran Hong, Youngmin Han, Yang-Ha Hwang, Boram Ohk, Jaechan Park
OBJECTIVE: To improve the process of surgical informed consent, patient attitudes towards acceptable levels of disability after decompressive surgery for malignant middle cerebral artery infarction are investigated, including the impact of patient age. METHODS: Patients who had experienced a recent minor stroke were asked to complete a questionnaire comprised of 2 parts: 1) demographic information, including patient age, gender, years of education, working status, religion, and economic status and 2) acceptable level of disability based on a modified Rankin Scale (mRS) with corresponding illustrations to explain the mRS levels...
February 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29456645/influence-of-exposure-to-nicotine-during-pregnancy-on-the-learning-and-memory-for-adult-offspring
#3
Xing-Dui Ma, Bei-Ping Li, Yuan Han, Yun-Ping Tian, Liang Wu, Hang Wang
We aimed to investigate the indirect influence of exposure to nicotine during pregnancy on the learning and memory of adult offspring mice. Thirty pregnant C57 mice were randomly divided into either the control group (CON) or the nicotine group (NIC), with 15 mice each. The CON group was given access to drug-free water, and the NIC group was given 60 g/ml nicotine in drinking water. Sixteen adult mice were randomly selected from the 8 litters for Morris water maze test. The level of products of related factors in the hippocampus of mice in the NIC and the CON groups were compared using the1 H-MRS method...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456347/the-evolving-pattern-and-outcome-of-stroke-at-moderate-altitude
#4
Deepika Dhiman, Sanjay K Mahajan, Sudhir Sharma, Rajiv Raina
Background: The people residing in hills of this Sub-Himalayan region traditionally have a distinct lifestyle involving high level of physical activity. However, increased urbanization in the last two decades has led to changes in lifestyle of people. The present study was an endeavor to document changes in the pattern of stroke in people residing at moderate altitude. Aim: This study was aimed to study the evolving trends in clinical profile, risk factors, and outcome at 3 months in hospitalized patients of stroke in a Tertiary Care Hospital situated at moderate altitude...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29455906/clinical-analysis-of-combined-revascularization-in-treating-ischemic-moyamoya-disease-in-adults
#5
Z Chen, L Zhang, J Qu, Y Wu, G Mao, X Zhu, J Zhu
OBJECTIVE: The aim of this study was to investigate the clinical efficacy of superficial temporal artery-middle cerebral artery anastomosis (STA-MCA)+encephalo-duro-myo-synangiosis (EDMS) in treating ischemic Moyamoya disease (IMD) in adults. METHODS: A total of 30 adult patients with IMD were selected to be included in the study; they underwent STA-MCA+EDMS and were followed up for 3 months to 2 years. The digital subtraction angiography findings, modified Rankin scale (mRs) score, and complications of all the patients were compared...
February 15, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29455454/oxidative-capacity-varies-along-the-length-of-healthy-human-tibialis-anterior
#6
Andreas Boss, Linda Heskamp, Vincent Breukels, Lauren J Bains, Mark J van Uden, Arend Heerschap
The rate of phosphocreatine (PCr) recovery (kPCr ) after exercise, characterizing muscle oxidative capacity, is traditionally assessed with unlocalized31 P magnetic resonance spectroscopy (MRS) using a single surface coil. However, because of intramuscular variation in fibre type and oxygen supply, kPCr may be non-uniform within muscles. We tested this along the length of the tibialis anterior (TA) muscle in 10 male volunteers. For this purpose we employed a 3T MR system with a31 P/1 H volume transmit coil combined with a home-built31 P phased-array receive probe, consisting of 5 coil elements covering the TA muscle length...
February 18, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29454110/study-of-lipid-metabolism-by-estimating-the-fat-fraction-in-different-breast-tissues-and-in-various-breast-tumor-sub-types-by-in-vivo-1-h-mr-spectroscopy
#7
Khushbu Agarwal, Uma Sharma, Sandeep Mathur, Vurthaluru Seenu, Rajinder Parshad, Naranamangalam R Jagannathan
PURPOSE: To evaluate the utility of fat fraction (FF) for the differentiation of different breast tissues and in various breast tumor subtypes using in vivo proton ( 1 H) magnetic resonance spectroscopy (MRS). METHODS: 1 H MRS was performed on 68 malignant, 35 benign, and 30 healthy volunteers at 1.5 T. Malignant breast tissues of patients were characterized into different subtypes based on the differences in the expression of hormone receptors and the FF was calculated...
February 14, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29454079/a-novel-metric-that-quantifies-risk-stratification-for-evaluating-diagnostic-tests-the-example-of-evaluating-cervical-cancer-screening-tests-across-populations
#8
Hormuzd A Katki, Mark Schiffman
Our work involves assessing whether new biomarkers might be useful for cervical-cancer screening across populations with different disease prevalences and biomarker distributions. When comparing across populations, we show that standard diagnostic accuracy statistics (predictive values, risk-differences, Youden's index and Area Under the Curve (AUC)) can easily be misinterpreted. We introduce an intuitively simple statistic for a 2 × 2 table, Mean Risk Stratification (MRS): the average change in risk (pre-test vs...
February 14, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29453464/dietitian-led-lifestyle-modification-programme-for-obese-chinese-adolescents-with-non-alcoholic-fatty-liver-disease-a-randomized-controlled-study
#9
D F Y Chan, H K So, S C N Hui, R S M Chan, A M Li, M M Sea, W C W Chu, M Chan, J Woo, E A S Nelson
BACKGROUND: The prevalence of non-alcoholic fatty liver disease (NAFLD) in children is increasing. This study evaluated the efficacy of a dietitian-led lifestyle modification programme (D-LMP) to reduce NAFLD in obese adolescents. METHODS: Subjects with intra-hepatic triglyceride content (IHTC) equal to or greater than 5% diagnosed by proton-magnetic resonance spectroscopy ( 1 H-MRS) were enroled and randomly assigned to either the D-LMP intervention or conventional paediatrician-led consultation (P-CON) group...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29449278/7t-brain-mrs-in-hiv-infection-correlation-with-cognitive-impairment-and-performance-on-neuropsychological-tests
#10
M Mohamed, P B Barker, R L Skolasky, N Sacktor
BACKGROUND AND PURPOSE: Validated neuroimaging markers of HIV-associated neurocognitive disorder in patients on antiretroviral therapy are urgently needed for clinical trials. The purpose of this study was to explore the relationship between cognitive impairment and brain metabolism in older subjects with HIV infection. It was hypothesized that MR spectroscopy measurements related to neuronal health and function (particularly N -acetylaspartate and glutamate) would be lower in HIV-positive subjects with worse cognitive performance...
February 15, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29449141/neurometabolites-alteration-in-the-acute-phase-of-mild-traumatic-brain-injury-mtbi-an-in-vivo-proton-magnetic-resonance-spectroscopy-1h-mrs-study
#11
Vigneswaran Veeramuthu, Pohchoo Seow, Vairavan Narayanan, Jeannie Hsiu Ding Wong, Li Kuo Tan, Aditya Tri Hernowo, Norlisah Ramli
RATIONALE AND OBJECTIVES: Magnetic resonance spectroscopy is a noninvasive imaging technique that allows for reliable assessment of microscopic changes in brain cytoarchitecture, neuronal injuries, and neurochemical changes resultant from traumatic insults. We aimed to evaluate the acute alteration of neurometabolites in complicated and uncomplicated mild traumatic brain injury (mTBI) patients in comparison to control subjects using proton magnetic resonance spectroscopy (1H magnetic resonance spectroscopy)...
February 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29448119/estimation-of-hepatic-fat-fraction-using-modified-dixon-magnetic-resonance-imaging-techniques-effect-of-liver-cirrhosis
#12
Jeeyoung Min, Hee Sun Park, Young Jun Kim, Mi Hye Yu, Sung Il Jung, Hae Jeong Jeon
PURPOSE: To evaluate modified Dixon MRI techniques in hepatic fat estimation and to assess the effect of cirrhosis. METHODS: 235 patients who underwent liver MRI were included. Correlation between modified Dixon techniques with MRS was assessed. Accuracy of MR techniques in hepatic fat estimation was calculated, and the result was compared between patients with/without liver cirrhosis. RESULTS: Correlation between modified Dixon and MRS was better in group without liver cirrhosis, and accuracy of modified Dixon method was higher in group without liver cirrhosis...
February 7, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29444560/cohort-studies-trials-and-tribulations-systematic-review-and-an-evidence-based-approach-to-avm-treatment
#13
Mary Simons, Michael K Morgan, Andrew S Davidson
INTRODUCTION: There is uncertainty as to the best management of arteriovenous malformations of the brain (bAVM). However, the Spetzler-Martin grade (SMG) has been validated as an effective determinant of surgical risks. We performed a systematic review for the best evidence regarding the management of bAVM for series that incorporate an analysis based upon SMG. EVIDENCE ACQUISITION: Medline, Embase, Scopus and Cochrane databases were searched for series between January 2000 and January 2018, with a minimum of 100 cases and that incorporated SMG stratification...
February 13, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29444252/human-striatal-response-to-reward-anticipation-linked-to-hippocampal-glutamate-levels
#14
Matthijs G Bossong, Robin Wilson, Elizabeth Appiah-Kusi, Philip McGuire, Sagnik Bhattacharyya
Background: Dysfunctional reward processing is associated with a number of psychiatric disorders, such as addiction and schizophrenia. It is thought that reward is regulated mainly by dopamine transmission in the ventral striatum. Contemporary animal models suggest that striatal dopamine concentrations and associated behaviours are related to glutamatergic functioning in the ventral hippocampus. However, in humans the association between reward-related ventral striatal response and hippocampal glutamate levels is unclear...
February 10, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29442388/maximizing-sensitivity-for-fast-gaba-edited-spectroscopy-in-the-visual-cortex-at-7%C3%A2-t
#15
Arjan D Hendriks, Alessio Fracasso, Catalina S Arteaga de Castro, Mark W J M Gosselink, Peter R Luijten, Natalia Petridou, Dennis W J Klomp
The combination of functional MRI (fMRI) and MRS is a promising approach to relate BOLD imaging to neuronal metabolism, especially at high field strength. However, typical scan times for GABA edited spectroscopy are of the order of 6-30 min, which is long compared with functional changes observed with fMRI. The aim of this study is to reduce scan time and increase GABA sensitivity for edited spectroscopy in the human visual cortex, by enlarging the volume of activated tissue in the primary visual cortex. A dedicated setup at 7 T for combined fMRI and GABA MRS is developed...
February 14, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29441487/prior-antiplatelet-therapy-is-not-associated-with-larger-hematoma-volume-or-hematoma-growth-in-intracerebral-hemorrhage
#16
Verena van Ginneken, Patricia Engel, Jochen B Fiebach, Heinrich J Audebert, Christian H Nolte, Andrea Rocco
Hematoma volume (HV) and hematoma growth (HG) predict mortality and poor outcome in intracerebral hemorrhage (ICH). While the influence of oral anticoagulation on HV, HG and outcome is well established, the effect of prior antiplatelet therapy (APT) remains uncertain. We retrospectively examined data from all patients with acute, primary ICH, and baseline head CT admitted to our department between January 2005 and February 2014. HV were calculated by ABC/2 method. HG was defined as present if HV increased between baseline and follow-up CT ≥ 30% or ≥ 6 mL...
February 14, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29440356/arterial-diameter-and-the-gender-disparity-in-stroke-thrombectomy-outcomes
#17
Mark A Davison, Bichun Ouyang, Kavantissa M Keppetipola, Michael Chen
BACKGROUND: Compared with males, females consistently fare worse following mechanical thrombectomy for large vessel ischemic strokes. Understanding why this gender disparity occurs may guide improvements in future treatment strategies. In this study, we aim to determine whether gender differences in cerebral arterial diameter correlate with clinical outcomes following stroke thrombectomy. METHODS: We performed an observational study of consecutive acute ischemic stroke patients undergoing mechanical thrombectomy at a single, urban tertiary care medical center...
February 12, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29439126/mechanical-thrombectomy-of-acute-ischemic-stroke-with-a-new-intermediate-aspiration-catheter-preliminary-results
#18
Fabrizio Sallustio, Enrico Pampana, Alessandro Davoli, Stefano Merolla, Giacomo Koch, Fana Alemseged, Marta Panella, Vittoria Carla D'Agostino, Francesco Mori, Daniele Morosetti, Daniel Konda, Sebastiano Fabiano, Marina Diomedi, Roberto Gandini
BACKGROUND AND PURPOSE: To report clinical and procedural outcomes of acute ischemic stroke patients after endovascular treatment with the new thromboaspiration catheter AXS Catalyst 6. METHODS: Patients with anterior and posterior circulation stroke were selected. Successful reperfusion defined as a Thrombolysis in Cerebral Infarction (TICI) score ≥2 b and 3-month functional independence defined as a modified Rankin Scale (mRS) ≤2 were the main efficacy outcomes...
February 8, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29439123/endovascular-thrombectomy-in-wake-up-stroke-and-stroke-with-unknown-symptom-onset
#19
P Bücke, M Aguilar Pérez, V Hellstern, M AlMatter, H Bäzner, H Henkes
BACKGROUND AND PURPOSE: Mechanical thrombectomy in acute ischemic stroke within 6 hours of symptom onset is effective and safe. However, in many patients, information on the beginning of symptoms is not available. Patients can be divided into those with wake-up stroke and daytime-unwitnessed stroke. Evidence on outcome and complications after mechanical thrombectomy in wake-up stroke and daytime-unwitnessed stroke is rare. A potential beneficial effect of mechanical thrombectomy in selected patients with wake-up stroke or daytime-unwitnessed stroke is suspected...
February 8, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29438510/diagnostic-accuracy-of-2-hydroxyglutarate-magnetic-resonance-spectroscopy-in-newly-diagnosed-brain-mass-and-suspected-recurrent-gliomas
#20
Min Zhou, Yue Zhou, Huijun Liao, Benjamin C Rowland, Xiangquan Kong, Nils D Arvold, David A Reardon, Patrick Y Wen, Alexander P Lin, Raymond Y Huang
Background: Isocitrate dehydrogenase (IDH) mutations result in abnormal accumulation of 2-hydroxyglutarate (2HG) in gliomas that can be detected by MRS. We examined the diagnostic accuracy of 2HG single-voxel spectroscopy (SVS) and chemical shift imaging (CSI) in both newly-diagnosed and post-treatment settings. Methods: Long-TE (97 ms) SVS and CSI were acquired in 85 subjects, including a discovery cohort of 39 patients who had postoperative residual or recurrent glioma with confirmed IDH-mutation status and 6 normal volunteers, a prospective preoperative validation cohort of 24 patients with newly-diagnosed brain mass, and a prospective recurrent-lesion validation cohort of 16 previously-treated IDH-mutant glioma patients with suspected tumor recurrence...
February 9, 2018: Neuro-oncology
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