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https://www.readbyqxmd.com/read/28333831/deployed-skills-training-for-whole-blood-collection-by-a-special-operations-expeditionary-surgical-team
#1
Linda C Benavides, Iain M Smith, Jerome M Benavides, Douglas M Bowley, Heidi A Doughty, Jonathan B Lundy
BACKGROUND: Non-compressible hemorrhage is the leading cause of potentially preventable battlefield death. Combining casualty retrieval from the battlefield and damage control resuscitation (DCR) within the "golden hour" increases survival. However, transfusion requirements may exceed the current blood component stocks held by forward surgical teams. Warm fresh whole blood (WFWB) is an alternative. We report WFWB transfusion training developed by and delivered to a US Golden Hour Offset Surgical Treatment Team (GHOST-T) and the resulting improvement in confidence with WFWB transfusion...
March 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28327907/a-randomized-open-label-phase-2-study-of-everolimus-in-combination-with-pasireotide-lar-or-everolimus-alone-in-advanced-well-differentiated-progressive-pancreatic-neuroendocrine-tumors-cooperate-2-trial
#2
M H Kulke, P Ruszniewski, E Van Cutsem, C Lombard-Bohas, J W Valle, W W De Herder, M Pavel, E Degtyarev, J C Brase, L Bubuteishvili-Pacaud, M Voi, R Salazar, I Borbath, N Fazio, D Smith, J Capdevila, R P Riechelmann, J C Yao
Background: Several studies have demonstrated the antitumor activity of first-generation somatostatin analogs (SSAs), primarily targeting somatostatin receptor (sstr) subtypes 2 and 5, in neuroendocrine tumors (NET). Pasireotide, a second-generation SSA, targets multiple sstr subtypes. We compared the efficacy and safety of pasireotide plus everolimus to everolimus alone in patients with advanced, well-differentiated, progressive pancreatic NET (pNET). Patients and methods: Patients were randomized 1:1 to receive a combination of everolimus (10 mg/d, orally) and pasireotide long-acting release (LAR; 60 mg/28 d, intramuscularly) or everolimus alone (10 mg/d, orally); stratified by prior SSA use, and baseline serum chromogranin A and neuron-specific enolase...
March 6, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28326669/limited-endoscopic-high-septoplasty-prior-to-endonasal-dacryocystorhinostomy-our-experience-of-nine-cases
#3
Sang-Wook Kim, Seong Chul Yeo, Yeon-Hee Joo, Hyun-Jin Cho, Seong Wook Seo, Sea-Yuong Jeon
Primary acquired nasolacrimal duct obstruction is a clinical syndrome of unknown cause, manifested by epiphora, infection, blurred vision, and ocular and facial pain. Conservative care is usually ineffective in patients with chronic conditions; thus, dacryocystorhinostomy (DCR) has become the gold standard of treatment for such patients. Since the advent of endoscopic technologies, most patients have undergone endonasal (EN-)DCR; the success rate is comparable to that of external (EX-)DCR. This article is protected by copyright...
March 22, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28324747/optimal-dose-reduction-of-folfirinox-for-preserving-tumour-response-in-advanced-pancreatic-cancer-using-cumulative-relative-dose-intensity
#4
Jong-Chan Lee, Jin Won Kim, Soyeon Ahn, Hyoung Woo Kim, Jongchan Lee, Young Hoon Kim, Kyu-Hyun Paik, Jaihwan Kim, Jin-Hyeok Hwang
BACKGROUND: FOLFIRINOX has increased efficacy but also toxicity. Despite various modified FOLFIRINOX regimens, how much reduction is acceptable remains unclear. This study aimed to find the optimal relative dose intensity (RDI, %) of FOLFIRINOX that preserves tumour responses in patients with advanced pancreatic cancer (PC). METHODS: We reviewed 201 patients with PC treated with first-line FOLFIRINOX during 2012-2015. We established a modified Hryniuk model (http://www...
March 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28324247/fulvestrant-plus-targeted-agents-versus-fulvestrant-alone-for-treatment-of-hormone-receptor-positive-advanced-breast-cancer-progressed-on-previous-endocrine-therapy-a-meta-analysis-of-randomized-controlled-trials
#5
REVIEW
Wen-Zhao Lin, Qi-Ni Xu, Hong-Biao Wang, Xu-Yuan Li
To compare the addition of targeted agents to fulvestrant with fulvestrant alone in hormone-receptor positive advanced breast cancer progressed on previous endocrine therapy; a meta-analysis of all relevant randomized controlled trials was performed. The PubMed, Embase databases and the Cochrane Central Register of Controlled Trials were searched for relevant publications reporting randomized controlled trials between January 2000 and June 2016. Progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and toxicity were assessed...
March 21, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28321534/factors-influencing-endoscopic-dacryocystorhinostomy-outcome
#6
Kazuhiro Nomura, Kazuya Arakawa, Mitsuru Sugawara, Hiroshi Hidaka, Jun Suzuki, Yukio Katori
Endoscopic dacryocystorhinostomy (DCR) is a widely accepted treatment option for epiphora and dacryocystitis. To elucidate the cause of treatment failure after surgery, we analyzed patients' characteristics and perioperative background in association with poor outcome. We analyzed 165 patients with 213 sides who had endoscopic DCR. The influence of age, duration of symptoms, occlusion site and stent insertion were analyzed. Symptoms were completely cured in 85.0% (181/213) sides. Higher age (≥65 years) and proximal obstruction were associated with a poor prognosis while stent insertion and duration of symptoms were not...
March 20, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28320683/the-designated-convergence-rate-problems-of-consensus-or-flocking-of-double-integrator-agents-with-general-nonequal-velocity-and-position-couplings-further-results-and-patterns-of-convergence-rate-contours
#7
Wei Li
This paper considers the designated convergence rate (DCR) (or the designated convergence margin) problems of consensus or flocking of coupled double-integrator agents. The DCR problems are more valuable for systems design than just convergence or stability conditions. The system setting in this paper is general, i.e., the velocity coupling and position coupling (VCPC) between agents, respectively, are set to be general and nonequal (up to rescaling), together with distinct damping and stiffness gains for the VCPC, respectively...
March 14, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28296721/single-pemetrexed-is-noninferior-to-platinum-based-pemetrexed-doublet-as-first-line-treatment-on-elderly-chinese-patients-with-advanced-nonsquamous-nonsmall-cell-lung-cancer
#8
COMPARATIVE STUDY
Xiaolin Pu, Wei Li, Binbin Lu, Zhaoxia Wang, Min Yang, Weifei Fan, Lijuan Meng, Zhigang Lv, Yuchun Xie, Jun Wang
BACKGROUND: To evaluate the clinical efficacy and toxicity of single pemetrexed treatment compared with platinum-based pemetrexed doublet pemetrexed-based as first-line treatment for advanced nonsquamous nonsmall cell lung cancer (NS-NSCLC) in elderly Chinese patients. METHODS: The study retrospectively reviewed 175 elderly Chinese patients with NS-NSCLC from June 2010 to September 2013: 90 patients received single pemetrexed treatment, 45 received pemetrexed plus oxaliplatin, and 40 received pemetrexed plus carboplatin...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28267010/regenerating-the-anal-sphincter-cytokines-stem-cells-or-both
#9
Li Sun, Zhuojun Xie, Mei Kuang, Marc Penn, Margot S Damaser, Massarat Zutshi
BACKGROUND: Healing of an anal sphincter defect at a time distant from injury is a challenge. OBJECTIVE: We aimed to investigate whether re-establishing stem cell homing at the site of an anal sphincter defect when cytokine expression has declined using a plasmid engineered to express stromal derived factor 1 with or without mesenchymal stem cells can improve anatomic and functional outcome. DESIGN: This was a randomized animal study. SETTINGS: Thirty-two female age- and weight-matched Sprague Dawley rats underwent 50% excision of the anal sphincter complex...
April 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28267005/mri-for-local-staging-of-colon-cancer-can-mri-become-the-optimal-staging-modality-for-patients-with-colon-cancer
#10
Elias Nerad, Doenja M J Lambregts, Erik L J Kersten, Monique Maas, Frans C H Bakers, Harrie C M van den Bosch, Heike I Grabsch, Regina G H Beets-Tan, Max J Lahaye
BACKGROUND: Colon cancer is currently staged with CT. However, MRI is superior in the detection of colorectal liver metastasis, and MRI is standard in local staging of rectal cancer. Optimal (local) staging of colon cancer could become crucial in selecting patients for neoadjuvant treatment in the near future (Fluoropyrimidine Oxaliplatin and Targeted Receptor Preoperative Therapy trial). OBJECTIVE: The purpose of this study was to evaluate the diagnostic performance of MRI for local staging of colon cancer...
April 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28265454/fluid-resuscitation-in-haemorrhagic-shock-in-combat-casualties
#11
REVIEW
Parli R Ravi, Bipin Puri
This brief update reviews the recent literature available on fluid resuscitation from hemorrhagic shock and considers the applicability of this evidence for use in resuscitation of combat casualties in the combat casualty care (CCC) environment. A number of changes need to be incorporated in the CCC guidelines: (1) dried plasma (DP) is added as an option when other blood components or whole blood are not available; (2) the wording is clarified to emphasize that Hetastarch is a less desirable option than whole blood, blood components, or DP and should be used only when these preferred options are not available; (3) the use of blood products in certain tactical field care settings where this option might be feasible (FSC, GH) is discussed; (4) 1:1:1 damage control resuscitation (DCR) with plasma: packed red blood cells (PRBC): platelets is preferred to 1:1 DCR with plasma: PRBC when platelets are available; and (5) the 30-min wait between increments of resuscitation fluid administered to achieve clinical improvement or target blood pressure has been eliminated...
2017: Disaster Mil Med
https://www.readbyqxmd.com/read/28265394/foreign-body-mimicking-malignancy-in-acquired-dacryocystocele
#12
Ahmad A Mirza, Atheer F Alsharif, Omar A Elmays, Osama A Marglani
A featured malignant-like granulation tissue can be the only preoperative clinical clue of a concealed foreign body in the nasal cavity. Thus, endoscopic Dacryocystorhinostomy (DCR) should be completed with intraoperative nasal exploration to reveal non-apparent foreign bodies that might be the underlying etiology of chronic dacryocystocele.
March 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28259104/association-of-oncogenic-mutations-in-patients-with-advanced-cutaneous-squamous-cell-carcinomas-treated-with-cetuximab
#13
Alexandra Picard, Florence Pedeutour, Frédéric Peyrade, Laurence Saudes, Valérie Duranton-Tanneur, Emmanuel Chamorey, Nathalie Cardot-Leccia, Anne Sudaka, Marc Ettaiche, Maxime Benchetrit, Gilles Poissonnet, Nicolas Weinbreck, Bérengère Dadone, Jean-Philippe Lacour, Thierry Passeron, Henri Montaudié
Importance: Cetuximab was recently proposed for advanced cutaneous squamous cell carcinomas (cSCC); however, its efficacy is inconsistent and identification of predictive biomarkers for response is necessary. Objective: To search for somatic mutations of the HRAS, KRAS, NRAS, BRAF, and EGFR genes in patients with advanced cSCC treated with cetuximab; and to investigate the efficacy and tolerance of cetuximab according to these mutations. Design, Setting, and Participants: A multicentric and retrospective study of 31 patients (22 men, 9 women) with histologically confirmed advanced cSCC carried out in 1 department of dermatology and 2 departments of medical oncology in France between January 2008 and December 2014...
March 4, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28257135/the-value-of-lacrimal-scintillography-in-the-assessment-of-patients-with-epiphora
#14
O A Vonica, E Obi, Z Sipkova, C Soare, A R Pearson
PurposeTo assess the influence of dacryoscintillography (DSG) on the treatment decision for patients with epiphora and clinically patent non-functioning lacrimal systems.MethodsA retrospective 3-year review. Inclusion: patients having DSG for epiphora with delayed tear clearance, lacrimal system patency on syringing, and no visible external cause for watering. On the basis of regurgitation during syringing, tear ducts were divided into freely patent (FP≤20%) or stenosed. The DSG results were examined for correlation with symptoms and clinical examination, the influence on decision to proceed to dacryocystorhinostomy (DCR), and the ability to predict the surgical outcome...
March 3, 2017: Eye
https://www.readbyqxmd.com/read/28246394/somatic-embryogenesis-of-immature-cunninghamia-lanceolata-lamb-hook-zygotic-embryos
#15
Ruiyang Hu, Yuhan Sun, Bo Wu, Hongjing Duan, Huiquan Zheng, Dehuo Hu, Huazhong Lin, Zaikang Tong, Jinliang Xu, Yun Li
Two efficient somatic embryogenesis systems were developed in Chinese fir, the most important conifer for industrial wood production in China. Three development stages (cleavage polyembryony, dominant embryo, and precotyledon) of immature embryos derived from 25 genotypes of open-pollinated mother trees were used as initial explants. Cleavage polyembryony-stage embryos with a 12.44% induction rate was the most embryogenic response stage. The highest frequency of embryogenic callus (13.86%) induction was obtained from DCR medium supplemented with 1...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28243017/comparison-of-the-efficacies-of-0-94-mm-and-double-silicone-tubes-for-treatment-of-canalicular-obstruction
#16
Seong Chan Choi, Hye Sun Choi, Jae Woo Jang, Sung Joo Kim, Jung Hye Lee
PURPOSE: To compare the clinical effects of the single wide-diameter bicanalicular silicone tube and the double bicanalicular silicone tube in endonasal dacryocystorhinostomy (DCR) with canalicular trephinization for canalicular obstruction. METHODS: We retrospectively reviewed the records of 121 patients with monocanalicular or common canalicular obstruction who had undergone endonasal DCR with random bicanalicular insertion of either double silicone tubes (insertion of two tubes into each canaliculus) or a single wide-diameter (0...
February 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28242914/defatted-coconut-residue-crude-polysaccharides-as-potential-prebiotics-study-of-their-effects-on-proliferation-and-acidifying-activity-of-probiotics-in-vitro
#17
Nur 'Ain Najwa Mohd Nor, Sahar Abbasiliasi, Mohammed Nazrim Marikkar, Arbakariya Ariff, Mehrnoush Amid, Dhilia Udie Lamasudin, Mohd Yazid Abdul Manap, Shuhaimi Mustafa
This paper reports on the extraction, partial characterization and the potential application of crude polysaccharides from defatted coconut residue as a prebiotic. The coconut residue was defatted and extracted to obtain the crude polysaccharides and its physicochemical properties were determined. The crude polysaccharides were assessed for monosaccharide composition, total carbohydrate content, reducing sugar concentration and protein content determination. The functional group and structural elucidation of crude polysaccharides was also done using Fourier transform infrared spectra analysis...
January 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28239778/-minimally-invasive-bypass-surgery-for-nasolacrimal-duct-obstruction-transcanalicular-laser-assisted-dacryocystorhinostomy
#18
K R Koch, C Cursiefen, L M Heindl
BACKGROUND: In recent years, the minimally invasive surgical procedure of transcanalicular laser-assisted dacryocystorhinostomy (TKL-DCR) has gained importance in the treatment of primary acquired nasolacrimal duct obstructions (PANDO). OBJECTIVES: Surgical indications, functional success rates, potential advantages, and complications of TKL-DCR are presented and compared with the standard procedures external (EXT-DCR) and endonasal DCR (EN-DCR). METHODS: The study comprises a PubMed literature review and our own clinical results...
February 26, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28237146/is-routine-histopathological-examination-of-dacryocystorhinostomy-dacryocystectomy-specimens-necessary-a-tertiary-eye-hospital-experience
#19
Hind Alkatan, Majed Al-Qurashi
PURPOSE: Limited literature documenting the incidence of unsuspected malignant neoplasm among dacryocystorhinostomy/Dacryocystectomy (DCR/DCT) specimens is reviewed to determine if routine biopsy of all the patients undergoing such procedures is required. We are evaluating if sending lacrimal sac specimens for histopathological examination is necessary as a routine patient's care standard. STUDY DESIGN: This is a retrospective study of all lacrimal sac specimens received for histopathological examination in a tertiary eye hospital over a period of 12 years...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28231605/endonasal-versus-external-dacryocystorhinostomy-for-nasolacrimal-duct-obstruction
#20
REVIEW
Lona Jawaheer, Caroline J MacEwen, Deepa Anijeet
BACKGROUND: A dacryocystorhinostomy (DCR) procedure aims to restore drainage of tears by bypassing a blockage in the nasolacrimal duct, through the creation of a bony ostium that allows communication between the lacrimal sac and the nasal cavity. It can be performed using endonasal or external approaches. The comparative success rates of these two approaches have not yet been established and this review aims to evaluate the relevant up-to-date research. OBJECTIVES: The primary aim of this review is to compare the success rates of endonasal DCR with that of external DCR...
February 24, 2017: Cochrane Database of Systematic Reviews
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