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https://www.readbyqxmd.com/read/29157311/peripheral-and-local-predictive-immune-signatures-identified-in-a-phase-ii-trial-of-ipilimumab-with-carboplatin-paclitaxel-in-unresectable-stage-iii-or-stage-iv-melanoma
#1
Rahima Jamal, Réjean Lapointe, Eftihia Cocolakis, Paméla Thébault, Shirin Kazemi, Jennifer E Friedmann, Jeanne Dionne, Jean-François Cailhier, Karl Bélanger, Jean-Pierre Ayoub, Huy Le, Caroline Lambert, Jida El-Hajjar, Léon C van Kempen, Alan Spatz, Wilson H Miller
BACKGROUND: Checkpoint blockade with ipilimumab provides long-term survival to a significant proportion of patients with metastatic melanoma. New approaches to increase survival and to predict which patients will benefit from treatment are needed. This phase II trial combined ipilimumab with carboplatin/paclitaxel (CP) to assess its safety, efficacy, and to search for peripheral and tumor-based predictive biomarkers. METHODS: Thirty patients with untreated unresectable/metastatic melanoma were treated with ipilimumab and CP...
November 21, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29156837/meta-analysis-of-efficacy-and-adverse-events-of-erlotinib-based-targeted-therapies-for-advanced-metastatic-non-small-cell-lung-cancer
#2
Fei Li, Shu-Hua Zhang, Li-Min Pang
A network meta-analysis evaluating efficacy and adverse events of eight erlotinib-based therapies (erlotinib+placebo, erlotinib+tivantinib, erlotinib+celecoxib, erlotinib+onartuzumab, erlotinib+sunitinib, erlotinib+entinostat, erlotinib+sorafenib, and erlotinib+bevacizumab) for advanced/metastatic non-small-cell lung cancer (NSCLC) was performed. PubMed and Cochrane Library were reviewed, and ten randomized controlled trials were identified in which patients receiving at least one erlotinib-based therapy. Efficacy outcomes, including progression-free survival (PFS), overall survival (OS), overall response rate (ORR), disease control rate (DCR), and adverse outcomes were evaluated...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155518/a-meta-analysis-of-clinical-trials-over-regimens-with-or-without-cetuximab-for-advanced-gastric-cancer-patients
#3
Lianhua Ji, Dongying Gu, Xinguang Tan, Hui Sun, Jinfei Chen
PURPOSE: To evaluate the efficiency and toxicity of treatment with or without cetuximab in patients with advanced gastric cancer (AGC). METHODS: Randomized phase III clinical trials (RCTs) on chemotherapy with or without cetuximab for AGC were searched in PUBMED and CNKI. A total of 874 patients were analyzed for their overall survival (OS), disease control rate (DCR), and toxicity. Reported hazard ratio (HR) with 95% CI from each study were used as the primary outcome measure...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29152093/the-role-of-weekly-nanoparticle-albumin-bound-paclitaxel-monotherapy-as-second-line-or-later-treatment-for-advanced-nsclc-in-china
#4
Puyuan Xing, Yixiang Zhu, Ling Shan, Sipeng Chen, Xuezhi Hao, Junling Li
For patients with pretreated advanced non-small cell lung cancer (NSCLC), more effective treatments are unmet. We conducted a study to explore the optimal treatment schedule of nanoparticle albumin bound paclitaxel (Nab-PTX) as a second line or later treatment for advanced NSCLC patients in China. Ninety-eight patients, who had experienced failure of prior treatment and received Nab-PTX monotherapy (130 mg/m(2)) on days 1, 8 of a 21-day cycle were included. The median progression-free survival (PFS) and overall survival (OS) were 4...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29149761/crizotinib-achieves-long-lasting-disease-control-in-advanced-papillary-renal-cell-carcinoma-type-1-patients-with-met-mutations-or-amplification-eortc-90101-create-trial
#5
Patrick Schöffski, Agnieszka Wozniak, Bernard Escudier, Piotr Rutkowski, Alan Anthoney, Sebastian Bauer, Jozef Sufliarsky, Carla van Herpen, Lars H Lindner, Viktor Grünwald, Branko Zakotnik, Evelyne Lerut, Maria Debiec-Rychter, Sandrine Marréaud, Michela Lia, Tiana Raveloarivahy, Sandra Collette, Laurence Albiges
PURPOSE: Papillary renal-cell carcinoma type 1 (PRCC1) is associated with MET gene alterations. Our phase II trial prospectively assessed the efficacy and safety of crizotinib in patients with advanced/metastatic PRCC1 with or without MET mutations (MET+ and MET-). EXPERIMENTAL DESIGN: Eligible patients with reference pathology-confirmed PRCC1 received 250 mg oral crizotinib twice daily. Patients were attributed to MET+/MET- sub-cohorts by the sequencing of exons 16-19 of the MET gene in tumour tissue...
November 14, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29142802/metastatic-her2-breast-cancer-a-potentially-curable-disease
#6
Lisa Prior, Marvin Lim, Cian Ward, Hannah Featherstone, Hazel Murray, Clare D'Arcy, John Crown, Giuseppe Gullo
The advent of trastuzumab and other human epidermal growth factor receptor 2 (HER2)-directed therapies has revolutionized the treatment of metastatic HER2-positive breast cancer, leading to prolonged survival and appreciable clinical benefit for a substantial subset of patients. Previously, in a retrospective study at our institution, we observed that nearly 10% of patients achieved a durable complete remission (DCR) following a combination of HER2-directed therapy and cytotoxic chemotherapy. We are currently expanding this study to include patients who were treated since the initial introduction of trastuzumab...
September 5, 2017: Curēus
https://www.readbyqxmd.com/read/29142801/idiopathic-acquired-dacryocystocele-presenting-only-with-epiphora-a-very-rare-case-report
#7
Muhammad Jahanzaib Anwar, Saad A Choudhry, Muhammad Aadil, Ahmer Asif, Atif Ameer
A 42-years-old male presented with left medial canthal swelling, accompanied with only mild epiphora. There was no history of dacryocystitis, mid-facial trauma, surgery, or bloody tears. On examination, there was an immobile, subcutaneous, non-inflammatory mass below the medial canthal tendon. Lacrimal irrigation showed blockade at the nasolacrimal duct. A computerized axial tomography (CAT) scan revealed a non-enhancing, low-density, cystic lesion at the inferomedial margin of the orbit. There were no signs of bony erosion, consistent with idiopathic acquired dacryocystocele...
September 4, 2017: Curēus
https://www.readbyqxmd.com/read/29121183/primary-vs-secondary-endoscopic-dacryocystorhinostomy-for-acute-dacryocystitis-with-lacrimal-sac-abscess-formation-a-randomized-clinical-trial
#8
Emmy Y Li, Emily S Wong, Alex C Wong, Hunter K Yuen
Importance: Endoscopic dacryocystorhinostomy (EN-DCR) is emerging as the preferred procedure in the management of nasolacrimal duct obstructions. However, its safety and long-term efficacy in the setting of acute dacryocystitis with lacrimal sac abscess have not been well studied. Objective: To compare outcomes of EN-DCR as primary treatment with EN-DCR as a secondary treatment after percutaneous drainage of lacrimal sac abscess in acute dacryocystitis. Design, Setting, and Participants: This randomized clinical trial was conducted from October 1, 2012, to October 31, 2015, at a tertiary ophthalmic center...
November 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29112570/rectal-eversion-technique-a-method-to-achieve-very-low-rectal-transection-and-anastomosis-with-particular-value-in-laparoscopic-cases
#9
Vitaliy Poylin, Peter Mowschenson, Deborah Nagle, Thomas Cataldo
INTRODUCTION: Transection of the rectum at the anorectal junction is required for proper resection in ulcerative colitis and restorative proctocolectomy. Achieving stapled transection at the pelvic floor is often challenging, particularly during laparoscopic proctectomy. Transanal mucosectomy and handsewn anastomosis are frequently used to achieve adequate resection. Rectal eversion provides an alternative for low anorectal transection and maintains the ability to perform stapled anastomosis...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29112569/stromal-cell-derived-factor-1-plasmid-regenerates-both-smooth-and-skeletal-muscle-after-anal-sphincter-injury-in-the-long-term
#10
Li Sun, Mei Kuang, Marc Penn, Margot S Damaser, Massarat Zutshi
BACKGROUND: Regenerating muscle at a time remote from injury requires re-expression of cytokines to attract stem cells to start and sustain the process of repair. OBJECTIVE: We aimed to evaluate the sustainability of muscle regeneration after treatment with a nonviral plasmid expressing stromal cell-derived factor 1. DESIGN: This was a randomized study. SETTINGS: The study was conducted with animals in a single research facility...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29112568/sacral-nerve-stimulation-for-fecal-incontinence-how-long-should-the-test-phase-be
#11
Elsa Lambrescak, Vincent Wyart, Guillaume Meurette, Jean-Luc Faucheron, Christian Thomas, Patrick Atienza, Paul-Antoine Lehur, Isabelle Etienney
BACKGROUND: Decision-making for pulse generator implantation for sacral nerve stimulation in the management of fecal incontinence is based on the results of a test phase. Its duration is still a matter of debate. OBJECTIVE: The purpose of this study was to determine whether an early positive response during the test phase could predict implantation of a permanent sacral nerve pulse generator. DESIGN: This was a short-term observational cohort study...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29112567/a-pilot-study-of-the-prevalence-of-anal-human-papillomavirus-and-dysplasia-in-a-cohort-of-patients-with-ibd
#12
Ross D Cranston, Miguel Regueiro, Jana Hashash, Jonathan R Baker, Nicola Richardson-Harman, Laura Janocko, Ian McGowan
BACKGROUND: Defective cell-mediated immunity increases the risk of human papillomavirus-associated anal dysplasia and cancer. There is limited information on anal canal disease in patients with IBD. OBJECTIVE: The purpose of this study was to assess anal/vaginal human papillomavirus and anal dysplasia prevalence in patients with IBD. DESIGN: Patients had an anal examination before routine colonoscopy. SETTINGS: The study was conducted at a tertiary IBD referral center...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29112566/what-is-the-risk-of-anastomotic-leak-after-repeat-intestinal-resection-in-patients-with-crohn-s-disease
#13
W Forrest Johnston, Caitlin Stafford, Todd D Francone, Thomas E Read, Peter W Marcello, Patricia L Roberts, Rocco Ricciardi
BACKGROUND: Approximately half of Crohn's patients require intestinal resection, and many need repeat resections. OBJECTIVE: The purpose of this study was to evaluate the increased risk of clinical anastomotic leak in patients with a history of previous intestinal resection undergoing repeat resection with anastomosis for Crohn's disease. DESIGN: This was a retrospective analysis of prospectively collected departmental data with 100% capture...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29112565/a-randomized-control-trial-of-preoperative-oral-antibiotics-as-adjunct-therapy-to-systemic-antibiotics-for-preventing-surgical-site-infection-in-clean-contaminated-contaminated-and-dirty-type-of-colorectal-surgeries
#14
RANDOMIZED CONTROLLED TRIAL
Nadeem Anjum, Jianan Ren, Gefei Wang, Guanwei Li, Xiuwen Wu, Hu Dong, Qin Wu, Jieshou Li
BACKGROUND: Preoperative bowel preparation with or without oral antibiotics is controversial in terms of postoperative surgical site infections. OBJECTIVE: This study aimed to evaluate the efficacy of oral antibiotics as adjunct therapy to systemic antibiotics with mechanical bowel preparation for preventing surgical site infections in clean contaminated, contaminated, and dirty colorectal procedures. DESIGN: This was a single-center, prospective randomized study...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29112564/a-surgical-clostridium-associated-risk-of-death-score-predicts-mortality-after-colectomy-for-clostridium-difficile
#15
Audrey S Kulaylat, Zain Kassam, Christopher S Hollenbeak, David B Stewart
BACKGROUND: A Clostridium difficile-associated risk of death score was recently developed and validated by using a national cohort of both nonsurgical and surgical patients admitted with C difficile infection. However, risk scores specifically derived from surgical cohorts and designed for patients with C difficile infection are currently unavailable. OBJECTIVE: The aim of this study was to develop a risk of death score for patients with C difficile infection who are being considered for total abdominal colectomy because of the failure of medical therapy...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29112563/naples-prognostic-score-based-on-nutritional-and-inflammatory-status-is-an-independent-predictor-of-long-term-outcome-in-patients-undergoing-surgery-for-colorectal-cancer
#16
Gennaro Galizia, Eva Lieto, Annamaria Auricchio, Francesca Cardella, Andrea Mabilia, Vlasta Podzemny, Paolo Castellano, Michele Orditura, Vincenzo Napolitano
BACKGROUND: The existing scores reflecting the patient's nutritional and inflammatory status do not include all biomarkers and have been poorly studied in colorectal cancers. OBJECTIVE: The purpose of this study was to assess a new prognostic tool, the Naples prognostic score, comparing it with the prognostic nutritional index, controlling nutritional status score, and systemic inflammation score. DESIGN: This was an analysis of patients undergoing surgery for colorectal cancer...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29112562/initiation-of-a-transanal-total-mesorectal-excision-program-at-an-academic-training-program-evaluating-patient-safety-and-quality-outcomes
#17
Justin A Maykel, Uma R Phatak, Pasithorn A Suwanabol, Andrew T Schlussel, Jennifer S Davids, Paul R Sturrock, Karim Alavi
BACKGROUND: Short-term results have shown that transanal total mesorectal excision is safe and effective for patients with mid to low rectal cancers. Transanal total mesorectal excision is considered technically challenging; thus, adoption has been limited to a few academic centers in the United States. OBJECTIVE: The aim of this study is to describe outcomes after the initiation of a transanal total mesorectal excision program in the setting of an academic colorectal training program...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29112561/nodal-disease-in-rectal-cancer-patients-with-complete-tumor-response-after-neoadjuvant-chemoradiation-danger-below-calm-waters
#18
Rebeccah B Baucom, Lillias H Maguire, Sandra L Kavalukas, Timothy M Geiger, Molly M Ford, Roberta L Muldoon, M Benjamin Hopkins, Alexander T Hawkins
BACKGROUND: A subset of patients with rectal cancer who undergo neoadjuvant chemoradiation therapy will develop a complete pathologic tumor response. Complete nodal response is not universal in these patients and is difficult to assess clinically. Quantifying the risk of nodal disease would allow for targeted therapy with either radical resection or "watchful waiting." OBJECTIVE: This study aimed to identify risk factors for residual nodal disease in ypT0 rectal adenocarcinoma...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29112560/is-the-distance-worth-it-patients-with-rectal-cancer-traveling-to-high-volume-centers-experience-improved-outcomes
#19
Zhaomin Xu, Adan Z Becerra, Carla F Justiniano, Courtney I Boodry, Christopher T Aquina, Alex A Swanger, Larissa K Temple, Fergal J Fleming
BACKGROUND: It is unclear whether traveling long distances to high-volume centers would compensate for travel burden among patients undergoing rectal cancer resection. OBJECTIVE: The purpose of this study was to determine whether operative volume outweighs the advantages of being treated locally by comparing the outcomes of patients with rectal cancer treated at local, low-volume centers versus far, high-volume centers. DESIGN: This was a population-based study...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29112559/do-moderate-surgical-treatment-delays-influence-survival-in-colon-cancer
#20
Kerollos Nashat Wanis, Sanjay V B Patel, Muriel Brackstone
BACKGROUND: Studies examining treatment delay and survival after surgical treatment of colon cancer have varied in quality and outcome, with little evidence available regarding the safety of longer surgical treatment wait times. OBJECTIVE: Our study examined the effect of surgical treatment wait times on survival for patients with stage I to III colon cancer. DESIGN: A subset cohort analysis was performed using data from a prospectively maintained database...
December 2017: Diseases of the Colon and Rectum
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