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intraductal papillary mucinous neoplasms

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https://www.readbyqxmd.com/read/28545033/microrna-expression-levels-as-diagnostic-biomarkers-for-intraductal-papillary-mucinous-neoplasm
#1
Lei Wang, Jianming Zheng, Chang Sun, Li Wang, Gang Jin, Lei Xin, Zhendong Jin, Dong Wang, Zhaoshen Li
Intraductal papillary mucinous neoplasms (IPMNs) are deadly exocrine mucinous tumors. Currently the molecular features and diagnostic markers of IPMNs are not well understood. In this study, we performed microRNA (miRNA) profiling assays to study the potential roles of miRNAs in IPMNs using 78 cases of IPMN patients and controls. When comparing the miRNA expression between IPMN patient samples and controls, we found that miR-210, miR-223, miR-221, miR-155 and miR-187 were differentially expressed in normal pancreas and IPMNs...
May 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28540626/cross-sectional-prevalence-of-pancreatic-cystic-lesions-in-patients-with-acromegaly-a-single-center-experience
#2
Yukiko Odake, Hidenori Fukuoka, Masaaki Yamamoto, Yoshifumi Arisaka, Junya Konishi, Kenichi Yoshida, Ryusaku Matsumoto, Hironori Bando, Kentaro Suda, Hitoshi Nishizawa, Genzo Iguchi, Shozo Yamada, Wataru Ogawa, Yutaka Takahashi
PURPOSE: Acromegaly is a disease associated with an increased risk for several kinds of neoplasms including colon and thyroid cancer. Although the association between acromegaly and pancreatic neoplasms has not been elucidated, it has recently been reported that GNAS gene mutations were found in 58% of intraductal papillary mucinous neoplasms (IPMNs), which are representative pancreatic cystic lesions, suggesting a link between IPMNs and acromegaly. To assess the prevalence of pancreatic cystic lesions in patients with acromegaly, we performed a retrospective cross-sectional single institute study...
May 24, 2017: Pituitary
https://www.readbyqxmd.com/read/28539816/hsa-mir-96-and-hsa-mir-217-expression-down-regulates-with-increasing-dysplasia-in-pancreatic-intraepithelial-neoplasias-and-intraductal-papillary-mucinous-neoplasms
#3
XiaoYan Chang, ChunKai Yu, Ji Li, Shuangni Yu, Jie Chen
AIM: To compare the clinicopathological features of pancreatic intraepithelial neoplasias (PanINs) and intraductal papillary mucinous neoplasms (IPMNs), and to investigate the role of hsa-miR-96 and hsa-miR-217 in these two lesions. Methods: Formalin-fixed paraffin-embedded pancreatic specimens were selected in this study, including 58 cases of pancreatic intraepithelial neoplasias (PanINs), 45 cases of pancreatic ductal adenocarcinomas (PDAs), and 57 cases of intraductal papillary mucinous neoplasms (IPMNs)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28528374/pancreatic-cysts-and-guidelines
#4
REVIEW
James J Farrell
Pancreatic cysts, especially incidental asymptomatic ones seen on noninvasive imaging such as CT or MR imaging, remain a clinical challenge. The etiology of such cysts may range from benign cysts without any malignant potential such as pancreatic pseudocysts and serous cystadenomas to premalignant or frankly malignant cysts such as mucinous cystic neoplasms, intraductal papillary mucinous neoplasms, cystic degeneration associated with solid tumors such as pancreatic ductal adenocarcinoma or pancreatic endocrine neoplasms, and solid pseudopapillary neoplasms...
May 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28512773/natural-history-of-intraductal-papillary-mucinous-neoplasm-and-non-neoplastic-cyst-long-term-imaging-follow-up-study
#5
Yuya Hisada, Naoyoshi Nagata, Koh Imbe, Yusuke Takasaki, Katsunori Sekine, Tsuyoshi Tajima, Mikio Yanase, Kazuma Fujimoto, Junichi Akiyama, Naomi Uemura
Pancreatic cyst is being detected with increasing frequency because of widespread use of sensitive abdominal imaging tests such as multidetector computed tomography (MDCT) and magnetic resonance imaging (MRI) [1, 2]. One study reported an incidental detection rate of 1% on MDCT studies performed for any reason [3]. Not only gastroenterologists, but also other physicians and surgeons, frequently encounter incidental pancreatic cyst. However, it is unclear how often and how long we should follow up patients with pancreatic cyst...
May 17, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28511237/performance-of-a-fully-disposable-digital-single-operator-cholangiopancreatoscope
#6
Raj J Shah, Isaac Raijman, Brian Brauer, Bora Gumustop, Douglas K Pleskow
Background and study aim Our aim was to evaluate the first use in humans of a new, single-use, digital, single-operator intraductal cholangiopancreatoscopy system (IDCP). Patients and methods Data were collected retrospectively from four US institutions between February 2015 and April 2015. The visual impression of neoplasia or benign findings with IDCP was determined by the performing endoscopist. High grade dysplasia, intraductal papillary mucinous neoplasm, neuroendocrine tumor, and malignancy were categorized as neoplasia...
May 16, 2017: Endoscopy
https://www.readbyqxmd.com/read/28511236/long-term-outcomes-after-endoscopic-ultrasound-guided-ablation-of-pancreatic-cysts
#7
Jun-Ho Choi, Dong Wan Seo, Tae Jun Song, Do Hyun Park, Sang Soo Lee, Sung Koo Lee, Myung-Hwan Kim
Background and study aims The aim of this study was to investigate the long-term outcomes after endoscopic ultrasound (EUS)-guided pancreatic cyst ablation. Patients and methods In a single-center, prospective study, 164 patients with pancreatic cysts underwent EUS-guided cyst ablation using ethanol with paclitaxel. The inclusion criteria were as follows: unilocular or oligolocular cysts; clinically indeterminate cysts that required EUS fine-needle aspiration; and/or cysts that grew during the observation period...
May 16, 2017: Endoscopy
https://www.readbyqxmd.com/read/28502930/branch-duct-intraductal-papillary-mucinous-neoplasms-of-the-pancreas-involving-type-1-localized-autoimmune-pancreatitis-with-normal-serum-igg4-levels-successfully-diagnosed-by-endoscopic-ultrasound-guided-fine-needle-aspiration-and-treated-without-pancreatic
#8
Shinsuke Koshita, Yutaka Noda, Kei Ito, Yoshihide Kanno, Takahisa Ogawa, Kaori Masu, Yoshiharu Masaki, Hiroaki Kusunose, Toshitaka Sakai, Toji Murabayashi, Sho Hasegawa, Fumisato Kozakai, Jun Horaguchi, Takashi Sawai
We herein report a 68-year-old man with branch duct intraductal papillary mucinous neoplasms of the pancreas (BD-IPMNs) involving type 1 localized autoimmune pancreatitis (AIP) with normal serum IgG4 levels. Although he was referred to our medical center due to suspicion of pancreatic cancer concomitant with BD-IPMNs, endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) revealed a mass suspected of being pancreatic cancer to be type 1 AIP. Steroid administration notably reduced the mass. Although the clinical diagnosis of pancreatic masses in patients with IPMN can be occasionally challenging, performing a pathological examination by EUS-FNA may prevent unnecessary pancreatic surgery in cases of possible AIP...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28495434/patterns-of-recurrence-and-long-term-outcomes-in-patients-who-underwent-pancreatectomy-for-intraductal-papillary-mucinous-neoplasms-with-high-grade-dysplasia-implications-for-surveillance-and-future-management-guidelines
#9
Aaron U Blackham, Matthew P Doepker, Barbara A Centeno, Gregory Springett, Jose M Pimiento, Mokenge Malafa, Pamela J Hodul
BACKGROUND: While intraductal papillary mucinous neoplasms (IPMNs) with high-grade dysplasia (HGD) are thought to represent non-invasive, high-risk lesions, its natural history following resection is unknown. METHODS: A retrospective review of HGD-IPMN patients (1999-2015) was performed. Recurrence patterns and clinical outcomes following pancreatectomy were analyzed and the indications for surgery were explored based on current guidelines. RESULTS: HGD was diagnosed in 100 of 314 patients (32%) following pancreatectomy for IPMN...
May 8, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28476582/enhanced-karyopherin-%C3%AE-2-expression-is-associated-with-carcinogenesis-in-patients-with-intraductal-papillary-mucinous-neoplasms
#10
Norio Kubo, Kenichiro Araki, Bolag Altan, Kouki Hoshino, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Toshihide Kato, Keitaro Hirai, Takehiko Yokobori, Fumiyoshi Saito, Hideki Suzuki, Hiroyuki Kuwano, Ken Shirabe
BACKGROUND/OBJECTIVES: Intraductal papillary mucinous neoplasms (IPMN) can become malignant. Karyopherin-α2 (KPNA2) plays a central role in nucleocytoplasmic transport and is associated with various types of cancer. The current study examined pancreatic KPNA2 expression in cancer patients and evaluated its association with clinicopathological factors, cancer cell proliferation. METHODS: KPNA2 expression was investigated by immunohistochemistry in 40 surgically resected IPMN samples and its association with clinicopathological factors and Ki-67 expression were examined...
April 23, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28470400/comparative-radiological-pathological-study-of-biliary-intraductal-tubulopapillary-neoplasm-and-biliary-intraductal-papillary-mucinous-neoplasm
#11
Chia-Hung Wu, Yi-Chen Yeh, Yu-Chuan Tsuei, Li-Kuo Huang, Chia-I Lin, Chien-An Liu, Hsiou-Shan Tseng, Yi-You Chiou, Nai-Chi Chiu
PURPOSE: Biliary tract intraductal tubulopapillary neoplasms (BT-ITPNs) and intraductal papillary mucinous neoplasms (BT-IPMNs) are rare and poorly described. Herein, we examined the magnetic resonance imaging (MRI) features of BT-ITPNs and BT-IPMNs and correlated them with key gross and microscopic pathological findings. METHODS: We retrospectively identified five patients with definitive pathological findings of BT-ITPN and available diagnostic MRI findings. Key MRI features were correlated to the gross and microscopic pathology and compared to those of BT-IPMNs (19 patients)...
May 3, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28464920/collision-of-ductal-adenocarcinoma-and-neuroendocrine-tumor-of-the-pancreas-a-case-report-and-review-of-the-literature
#12
Simone Serafini, Gianfranco Da Dalt, Gioia Pozza, Stella Blandamura, Michele Valmasoni, Stefano Merigliano, Cosimo Sperti
BACKGROUND: Simultaneous occurrence of exocrine and neuroendocrine tumors of the pancreas is very infrequent. We report a patient with an endocrine tumor in the pancreatic-duodenal area and extensive exocrine carcinoma involving the whole pancreas. CASE PRESENTATION: A 69-year-old woman was hospitalized in May 2016 for epigastric pain and weight loss. Her past medical history revealed an undefined main pancreatic duct dilation that was subsequently confirmed at CT scan (23 mm) and endoscopic ultrasound...
May 2, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28463669/pancreatic-cystic-lesions-diagnostic-management-and-indications-for-operation-part-i
#13
Ferdinand Bauer
We notice an increasing frequency in the detection and evaluation of pancreatic cystic lesions (PCLs) over the last three decades. They show awide spectrum of imaging and clinical features. The diagnosis and discrimination of these lesions are very important because of the risk for concurrent or later development of malignancy. The main reason is the increased awareness of these lesions and the extensive use of cross-sectional imaging, an always improving technique (1). Commonly, PCLs are diagnosed incidentally during investigation for often unrelated and nonspecific abdominal complaints using state-of-the art abdominal imaging (CT, MRT)...
March 2017: Chirurgia
https://www.readbyqxmd.com/read/28454324/stathmin-1-promotes-the-proliferation-and-malignant-transformation-of-pancreatic-intraductal-papillary-mucinous-neoplasms
#14
Akira Watanabe, Kenichiro Araki, Takehiko Yokobori, Bolag Altan, Norihiro Ishii, Mariko Tsukagoshi, Norio Kubo, Fumiyoshi Saito, Hideki Suzuki, Hiroyuki Kuwano
Pancreatic intraductal papillary mucinous neoplasms (IPMNs) are a type of pancreatic tumor, which have been identified following improvements in diagnostic imaging. However, the malignant transformation of IPMN has been difficult to diagnose clinically. To date, the mechanisms driving the progression of IPMN to cancer remain to be fully elucidated. The present study focused on Stathmin 1 (STMN1), a protein that is associated with the development of various types of cancer. The expression of STMN1 was examined immunohistochemically in tissues from cases of IPMN...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28446039/intraductal-papillary-mucinous-neoplasm-of-the-pancreas-epidemiology-risk-factors-diagnosis-and-management
#15
Linus Aronsson, Roland Andersson, Daniel Ansari
Intraductal papillary mucinous neoplasm (IPMN) is one of the most common cystic neoplasms of the pancreas. It is a heterogeneous disease and can be divided into ductal types and morphological subtypes. The incidence of IPMN is increasing, likely due to the widespread use of cross-sectional imaging and a growing elderly population. IPMN poses an increasing demand on the health care system. Current guidelines provide indications for surgery and recommendations for surveillance, but management of IPMN is still challenging in routine clinical practice...
April 27, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28444494/imaging-of-pancreatic-cystic-lesions-with-confocal-laser-endomicroscopy-an-ex-vivo-pilot-study
#16
Abdurrahman Kadayifci, Mustafa Atar, Michelle Yang, Carlos Fernandez-Del Castillo, Mari Mino-Kenudson, William R Brugge
BACKGROUND: The differential diagnosis of pancreatic cystic lesions (PCLs) is an increasingly common clinical challenge. Confocal laser endomicroscopy (CLE) may differentiate PCLs by imaging of the cyst wall. However, clinical experience is still limited, and better image definition and characterization of the cyst wall in a spectrum of cysts are needed. This experimental study aimed to expose detailed imaging characteristics of PCLs by CLE. METHODS: Patients who underwent surgery of a PCL were enrolled...
April 25, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28443205/a-pilot-study-of-radiologic-measures-of-abdominal-adiposity-weighty-contributors-to-early-pancreatic-carcinogenesis-worth-evaluating
#17
Jennifer B Permuth, Jung W Choi, Dung-Tsa Chen, Kun Jiang, Gina DeNicola, Jian-Nong Li, Domenico Coppola, Barbara A Centeno, Anthony Magliocco, Yoganand Balagurunathan, Nipun Merchant, Jose G Trevino, Daniel Jeong
OBJECTIVE: Intra-abdominal fat is a risk factor for pancreatic cancer (PC), but little is known about its contribution to PC precursors known as intraductal papillary mucinous neoplasms (IPMNs). Our goal was to evaluate quantitative radiologic measures of abdominal/visceral obesity as possible diagnostic markers of IPMN severity/pathology. METHODS: In a cohort of 34 surgically-resected, pathologically-confirmed IPMNs (17 benign; 17 malignant) with preoperative abdominal computed tomography (CT) images, we calculated body mass index (BMI) and four radiologic measures of obesity: total abdominal fat (TAF) area, visceral fat area (VFA), subcutaneous fat area (SFA), and visceral to subcutaneous fat ratio (V/S)...
February 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28438794/intraductal-oncocytic-papillary-neoplasm-a-benign-hepatic-cystic-neoplasm
#18
Angela Tong, Gregory Veillette, Alexandra Budhai, Anthony Gilet
A 61-year-old Asian man presented with severe right upper quadrant pain which had been worsening for several months. Laboratory results indicated elevated aspartate aminotransferase and alanine aminotransferase. The subsequent ultrasound, CT and MRI showed a large cystic mass with solid components and severe intrahepatic and extrahepatic biliary ductal dilatation. The mass was resected and pathology showed a well-demarcated mucinous cystic lesion with polygonal cells containing ovoid nuclei and abundant pink oncocytic cytoplasm...
April 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28426497/the-cost-of-surveying-intraductal-papillary-mucinous-neoplasms
#19
Shawn L Shah, Stuart R Gordon, Timothy B Gardner
No abstract text is available yet for this article.
May 2017: Pancreas
https://www.readbyqxmd.com/read/28416122/patients-with-a-resected-pancreatic-mucinous-cystic-neoplasm-have-a-better-prognosis-than-patients-with-an-intraductal-papillary-mucinous-neoplasm-a-large-single-institution-series
#20
James F Griffin, Andrew J Page, Georges J Samaha, Adrienne Christopher, Feriyl Bhaijee, Maryam K Pezhouh, Niek A Peters, Ralph H Hruban, Jin He, Martin A Makary, Anne Marie Lennon, John L Cameron, Christopher L Wolfgang, Matthew J Weiss
BACKGROUND/OBJECTIVES: Mucinous cystic neoplasms (MCNs) are rare pancreas tumors distinguished from intraductal papillary mucinous neoplasms (IPMNs) by the presence of ovarian-type stroma. Historical outcomes for MCNs vary due to previously ambiguous diagnostic criteria resulting in confusion with IPMNs. This study seeks to characterize and clarify the clinical features and long-term outcomes of MCNs versus IPMNs in the largest single-institution series of pathology-confirmed MCNs to date...
April 11, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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