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https://www.readbyqxmd.com/read/29624208/gemcitabine-based-chemotherapy-for-advanced-biliary-tract-carcinomas
#1
REVIEW
Omar Abdel-Rahman, Zeinab Elsayed, Hesham Elhalawani
BACKGROUND: Biliary tract cancers are a group of rare heterogeneous malignant tumours. They include intrahepatic and extrahepatic cholangiocarcinomas, gallbladder carcinomas, and ampullary carcinomas. Surgery remains the optimal modality of therapy leading to long-term survival for people diagnosed with resectable biliary tract carcinomas. Unfortunately, most people with biliary tract carcinomas are diagnosed with either unresectable locally-advanced or metastatic disease, and they are only suitable for palliative chemotherapy or supportive care...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29546687/determining-the-adequate-examined-lymph-node-count-in-resected-ampullary-adenocarcinoma-a-national-cohort-study
#2
Ibrahim Nassour, Alana Christie, Michael A Choti, John C Mansour, Rebecca M Minter, Patricio M Polanco, Mathew M Augustine, Matthew R Porembka, Xian-Jin Xie, Sam C Wang
BACKGROUND: The evaluation of lymph node involvement is an essential component of cancer staging. Examining an inadequate number of lymph nodes potentially results in understaging. Current guidelines for lymph node retrieval for ampullary adenocarcinoma are based on data extrapolated from other periampullary malignancies and may not be applicable. The aim of this study was to determine the number of lymph nodes that should be examined in resection specimens to optimize staging in ampullary adenocarcinoma...
March 15, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29540198/evaluation-of-tumor-m2-pyruvate-kinase-tumor-m2-pk-as-a-biomarker-for-pancreatic-cancer
#3
Indika A Bandara, Minas Baltatzis, Sudip Sanyal, Ajith K Siriwardena
BACKGROUND: Expression of the dimeric M2 isoenzyme of pyruvate kinase, termed Tumor M2-PK, is increased in some human cancers. This study evaluates the potential role of pre-operative Tumor M2-PK as a marker of prognosis in patients with pancreatic malignancy. METHODS: Seventy-three consecutive patients with a clinical diagnosis of pancreatic or peri-ampullary cancer were enrolled. Their median (range) age was 66 (23-83) years. Pre-operative samples of venous blood were taken for analysis of Tumor M2-PK...
March 14, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29511398/a-review-of-double-common-bile-duct-and-its-sequelae
#4
REVIEW
Sindhura Kolli, Denzil Etienne, Madhavi Reddy, Ghulamullah Shahzad
A double or accessory common bile duct (ACBD) is a rare congenital anomaly. We report the case of a 60-year-old American Asian male, who was found to have a double or duplicated common bile duct after being admitted for evaluation of a pancreatic mass. A duplicated bile duct has the same mucosa histologically as a single bile duct. However, the opening of a duplicated bile duct lacks a sphincter allowing retrograde flow of gut contents which results in a higher probability of intraductal calculus formation...
February 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29506768/prognostic-factors-and-benefits-of-adjuvant-therapy-after-pancreatoduodenectomy-for-ampullary-adenocarcinoma-mayo-clinic-experience
#5
Zhaohui Jin, Mindy L Hartgers, Cristobal T Sanhueza, Christopher R Shubert, Steven R Alberts, Mark J Truty, Prasuna Muppa, David M Nagorney, Thomas C Smyrk, Mohamed Hassan, Amit Mahipal
INTRODUCTION: Ampullary adenocarcinoma is a rare entity with limited data on prognostic factors. The aim of this study is to identify prognostic factors and assess the benefit of adjuvant therapy in patients with ampullary adenocarcinoma who underwent pancreatoduodenectomy. METHODS: A cohort of 121 consecutive patients underwent pancreatoduodenectomy for ampullary adenocarcinoma from 2006 to 2016 at Mayo Clinic in Rochester, MN. All patients were confirmed by independent pathologic review to have ampullary carcinoma...
February 16, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29500184/ipmns-with-co-occurring-invasive-cancers-neighbours-but-not-always-relatives
#6
Matthäus Felsenstein, Michaël Noë, David L Masica, Waki Hosoda, Peter Chianchiano, Catherine G Fischer, Gemma Lionheart, Lodewijk A A Brosens, Antonio Pea, Jun Yu, Georgios Gemenetzis, Vincent P Groot, Martin A Makary, Jin He, Matthew J Weiss, John L Cameron, Christopher L Wolfgang, Ralph H Hruban, Nicholas J Roberts, Rachel Karchin, Michael G Goggins, Laura D Wood
OBJECTIVE: Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions that can give rise to invasive pancreatic carcinoma. Although approximately 8% of patients with resected pancreatic ductal adenocarcinoma have a co-occurring IPMN, the precise genetic relationship between these two lesions has not been systematically investigated. DESIGN: We analysed all available patients with co-occurring IPMN and invasive intrapancreatic carcinoma over a 10-year period at a single institution...
March 2, 2018: Gut
https://www.readbyqxmd.com/read/29497964/adjuvant-radiotherapy-following-pancreaticoduodenectomy-for-ampullary-adenocarcinoma-improves-survival-in-node-positive-patients-a-propensity-score-analysis
#7
S K Kamarajah
INTRODUCTION: This study aimed to evaluate the impact of adjuvant radiotherapy in patients undergoing pancreaticoduodenectomy (PD) for ampullary adenocarcinoma. METHODS: Using the Surveillance, Epidemiology, and End Results, patients with non-metastatic ampullary adenocarcinoma between 2004 and 2013 were identified. Cancer-specific survival and overall survival were estimated using Kaplan-Meier and Cox regression to obtain adjusted hazard ratio of survival. RESULTS: In this study, 1106 patients with ampullary adenocarcinoma were identified, of which 27% received adjuvant radiotherapy and the remaining 73% (803/1106) patients did not receive any adjuvant radiotherapy...
March 1, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29483427/-a-case-of-transduodenal-ampullectomy-for-an-ampullary-neoplasm-coexisting-with-gastric-and-colon-cancer
#8
Shigeru Fujisaki, Motoi Takashina, Yukari Woo, Ryouichi Tomita, Kenichi Sakurai, Tadatoshi Takayama
We present here a case of transduodenal ampullectomy for an ampullary neoplasm coexisting with gastric and colon cancer. The patient was a 72-year-old man who was referred to our hospital with a positive fecal blood test. Colonoscopy revealed advanced cancer in the descending colon. As part of the preoperative examination, for the colonic cancer, upper gastrointestinal endoscopy was performed. Endoscopy showed a 2 cm elevated lesion(0'-II a type)with subserosalinfil tration on the small curvature side of the upper part of the stomach, and a 2 cm elevated lesion on the papilla of Vater...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29464344/a-novel-classification-and-staged-approach-for-dissection-along-the-celiac-and-hepatic-artery-during-pancreaticoduodenectomy
#9
Yosuke Inoue, Akio Saiura, Yu Takahashi
BACKGROUND: In recent decades, there have been enthusiastic discussions of, and active proposals for, new approaches to dissection around the superior mesenteric artery during pancreaticoduodenectomy (PD). In contrast, dissection along the celiac axis (CA) and hepatic artery (HA) and in the hepatoduodenal ligament has rarely been systematically discussed. In this report, we propose and describe a three-level classification of dissection along the CA-HA system which is applicable to a variety of diseases for which PD is indicated...
February 20, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29452703/validation-of-the-eighth-edition-of-the-american-joint-committee-on-cancer-staging-system-for-ampulla-of-vater-cancer
#10
Sung Joo Kim, Soyeon An, Hyo Jeong Kang, Joo Young Kim, Min Ah Jang, Jae Hoon Lee, Ki-Byung Song, Dae Wook Hwang, HyungJun Cho, Song Cheol Kim, Eunsil Yu, Seung-Mo Hong
BACKGROUND: The American Joint Committee on Cancer recently proposed the eighth edition of cancer staging system. Validation studies are required to evaluate the prognostic stratification of ampulla of Vater cancer patients. METHODS: In the study, 369 operatively resected patients with ampullary cancers were grouped based on the eighth T (T1a, limited to sphincter of Oddi; T1b, invasion to duodenal submucosa; T2, invasion to duodenal proper muscle; T3a, invasion to pancreas ≤0...
February 13, 2018: Surgery
https://www.readbyqxmd.com/read/29435287/secondary-tumours-of-the-ampulla-of-vater-case-report-and-review-of-the-literature
#11
Francesca Sarocchi, Magdalena M Gilg, Florian Schreiber, Cord Langner
Secondary tumours of the ampulla of Vater are rare. Underlying primary tumours, clinical presentation, macroscopic appearance, treatment strategies and outcome of secondary ampullary lesions have not been systematically analysed. The present case study reported a 57-year old patient with an ampullary metastasis from renal cancer and a literature review was performed in which a further 32 patients were included. The most common responsible primary tumours were malignant melanoma and renal clear cell carcinoma, followed by breast cancer...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29394761/-clinical-outcome-of-hepatectomy-of-liver-metastasis-of-duodenal-ampullary-cancer
#12
Hiroyoshi Matsukawa, Shigehiro Shiozaki, Daisuke Satoh, Hitoshi Idani, Yasutomo Ojima, Masao Harano, Kanyu Nakano, Yasuhiro Choda, Daisuke Sumitani, Michihiro Ishida, Soichiro Miyake, Tetsushi Kubota, Masazumi Okajima
We evaluated the clinical outcome and assessed the indication of hepatectomy for liver metastasis of duodenal ampullary cancer. We analyzed 42 cases of duodenal ampullary cancer and 4 patients who underwent hepatectomy for liver metastasis. Eleven(50%)of 22 cases with recurrence of duodenal ampullary cancer had liver metastasis. Four cases were solitary and 7 cases were multiple. Four patients underwent hepatectomy didn't had other organ metastasis. Three of 4 cases with solitary liver metastases and one of 7 cases with multiple metastasis underwent hepatectomy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29335829/pancreaticoduodenectomy-for-periampullary-tumours-a-review-article-based-on-surveillance-end-results-and-epidemiology-seer-database
#13
REVIEW
S K Kamarajah
INTRODUCTION: This study set to examine relative survival of patients with periampullary cancers undergoing pancreaticoduodenectomy (PD). METHODS: Using the Surveillance, End Results and Epidemiology (SEER) database, this study identified 9877 patients with non-metastatic pancreatic adenocarcinoma who underwent PD between 2004 and 2013. RESULTS: Ampullary carcinomas have the best survival among periampullary malignancies. Lymph node ratio is a significant prognostic factor, even when stratified by tumour types...
January 15, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29307199/pathologic-classification-of-pancreatic-cancers-current-concepts-and-challenges
#14
Mohamed E Mostafa, Ipek Erbarut-Seven, Burcin Pehlivanoglu, Volkan Adsay
As the most common and most important cancer of the pancreas, with rapid mortality and now also as the third leading cause of cancer-related deaths in the United States, pancreatic ductal adenocarcinoma (PDAC) has become synonymous with "pancreas cancer". PDAC is also the prototype of the "pancreatobiliary-type" adenocarcinomas, along the biliary tract, ampullary and gallbladder cancers with the similar morphology and behavior. Recent molecular profiling studies have identified distinct subsets of PDAC, potentially with different behaviors and targetability...
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29296236/combined-microrna-and-mrna-microfluidic-taqman-array-cards-for-the-diagnosis-of-malignancy-of-multiple-types-of-pancreatico-biliary-tumors-in-fine-needle-aspiration-material
#15
Thomas M Gress, Ludwig Lausser, Lyn-Rouven Schirra, Lisa Ortmüller, Ramona Diels, Bo Kong, Christoph W Michalski, Thilo Hackert, Oliver Strobel, Nathalia A Giese, Miriam Schenk, Rita T Lawlor, Aldo Scarpa, Hans A Kestler, Malte Buchholz
Pancreatic ductal adenocarcinoma (PDAC) continues to carry the lowest survival rates among all solid tumors. A marked resistance against available therapies, late clinical presentation and insufficient means for early diagnosis contribute to the dismal prognosis. Novel biomarkers are thus required to aid treatment decisions and improve patient outcomes. We describe here a multi-omics molecular platform that allows for the first time to simultaneously analyze miRNA and mRNA expression patterns from minimal amounts of biopsy material on a single microfluidic TaqMan Array card...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29259073/phase-ii-study-of-panitumumab-in-ras-wild-type-metastatic-adenocarcinoma-of-small-bowel-or-ampulla-of-vater
#16
Pat Gulhati, Kanwal Raghav, Rachna Shroff, Gauri Varadhachary, Milind Javle, Wei Qiao, Huamin Wang, Jeffrey Morris, Robert Wolff, Michael J Overman
LESSONS LEARNED: Panitumumab has no clinical activity in metastatic RAS wild-type small bowel adenocarcinoma (SBA) and ampullary adenocarcinoma (AAC), possibly due to the foregut and midgut derivation of small bowel and ampulla.These results, along with findings from genomic characterization of SBA, suggest that SBA represents a unique intestinal malignancy and treatments should not be habitually extrapolated from colorectal cancer.Further studies evaluating the benefit of targeted therapies exclusively in SBA and AAC are warranted...
March 2018: Oncologist
https://www.readbyqxmd.com/read/29245285/perioperative-transfusion-in-pancreatoduodenectomy-the-double-edged-sword-of-pancreatic-surgeons
#17
Hyeong Min Park, Sang-Jae Park, Jae Ryong Shim, Eung Chang Lee, Seung Duk Lee, Sung-Sik Han, Seoung Hoon Kim
We designed the study to clarify the prognostic significance of perioperative (preoperative, intraoperative, and postoperative) red blood cell (RBC) transfusion following pancreaticoduodenectomy (PD) for periampullary cancers.This study retrospectively analyzed 244 periampullary cancer patients (pancreatic cancer, 124 patients; bile duct cancer, 63 patients; and ampullary cancer, 57 patients) treated by PD from June 2001 to June 2010 at the National Cancer Center, Korea (NCC2017-0106).A total of 112 (46%) of 244 patients had received transfusion (preoperative, 5%; intraoperative, 17%; and postoperative, 37%)...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29215725/prognostic-impact-of-circulating-tumor-cells-in-patients-with-ampullary-cancer
#18
Bo Sun, Han Liu, Shengnan Wang, Jianbin Xiang, Xingdang Liu
Circulating tumor cells (CTCs) are an important topic of investigation for both basic and clinical cancer research. In this prospective study, we evaluated the clinical role of CTCs in ampullary cancer. We analyzed blood samples from 62 consecutively diagnosed patients with ampullary adenocarcinoma and 24 healthy controls for their CTC content. Combined data from immunostaining of CD45, 4',6-diamidino-2-phenylindole (DAPI), and fluorescence in situ hybridization with a chromosome 8 centromere (CEP8) probe were used to identify CTCs; cells that were CD45-/DAPI+/CEP8>2 were considered CTCs...
June 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29159772/total-pancreatectomy-with-islet-autotransplantation-for-the-ampullary-cancer-a-case-report
#19
Omid Savari, Karolina Golab, Julia Solomina, Evelyn Konsur, Kamil Cieply, Sabarinathan Ramachandran, Zehra Tekin, Lindsay Schenck, Sharon S Zhang, Martin Tibudan, Mitchell C Posner, Piotr Witkowski
No abstract text is available yet for this article.
November 21, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29146616/therapeutic-potential-of-afatinib-for-cancers-with-erbb2-her2-transmembrane-domain-mutations-g660d-and-v659e
#20
Hiromasa Yamamoto, Shinichi Toyooka, Takashi Ninomiya, Shigemi Matsumoto, Masashi Kanai, Shuta Tomida, Katsuyuki Kiura, Manabu Muto, Ken Suzawa, Patrice Desmeules, Mark G Kris, Bob T Li, Marc Ladanyi
We previously reported on a family with hereditary lung cancer, in which a germline mutation in the transmembrane domain (G660D) of avian erythroblastic leukemia viral oncogene homolog 2 (erb-b2 receptor tyrosine kinase 2) (ERBB2; human epidermal growth factor receptor 2 [HER2]) seemed to be responsible for the cancer predisposition. Although few data are available on treatment, anti-ERBB2 therapeutic agents may be effective for ERBB2-mutant cancers. The familial lung cancer patient in one of the authors' institutes developed bone metastasis with enlarging lung tumors and was treated with the ERBB2 inhibitor afatinib...
November 16, 2017: Oncologist
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