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Hypoxic ischaemic encephalopathy

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https://www.readbyqxmd.com/read/27902983/perinatal-asphyxia-and-erythropoietin-and-vegf-serial-serum-and-cerebrospinal-fluid-responses
#1
Deirdre U Sweetman, Chike Onwuneme, William R Watson, John F A Murphy, Eleanor J Molloy
BACKGROUND: Infants with neonatal encephalopathy (NE) of hypoxic-ischaemic origin are at risk of oxidative and ischaemia-reperfusion injury, which may induce abnormal inflammatory responses involving excessive cytokine production and release in serum and cerebrospinal fluid (CSF). Systemic inflammation is found in infants with NE, and we therefore were interested in cytokines associated with hypoxia, including vascular endothelial growth factor (VEGF) and erythropoietin (Epo). OBJECTIVE: To investigate the relationship between Epo, VEGF levels, brain injury and outcome in a group of term infants exposed to perinatal asphyxia (PA) compared to controls...
December 1, 2016: Neonatology
https://www.readbyqxmd.com/read/27885286/immediate-outcome-of-hypoxic-ischaemic-encephalopathy-in-hypoxiate-newborns-in-nepal-medical-college
#2
S Shrestha, G S Shrestha, A Sharma
BACKGROUND: Birth asphyxia is the fifth major cause of under-five child deaths after pneumonia, diarrhoea, neonatal infections and complications of preterm birth. It is one of the important causes of neonatal mortality and morbidity accounting up to 30% of neonatal death in Nepal. It is also an important cause of long-term neurological disability and impairment. The mortality rate due to birth asphyxia is considered a good guide to the quality of perinatal care. This study was conducted to assess the rate of birth asphyxia, risk factors and outcome of the babies who were asphyxiated at birth...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27824913/treatment-trials-for-neonatal-seizures-the-effect-of-design-on-sample-size
#3
Nathan J Stevenson, Geraldine B Boylan, Lena Hellström-Westas, Sampsa Vanhatalo
Neonatal seizures are common in the neonatal intensive care unit. Clinicians treat these seizures with several anti-epileptic drugs (AEDs) to reduce seizures in a neonate. Current AEDs exhibit sub-optimal efficacy and several randomized control trials (RCT) of novel AEDs are planned. The aim of this study was to measure the influence of trial design on the required sample size of a RCT. We used seizure time courses from 41 term neonates with hypoxic ischaemic encephalopathy to build seizure treatment trial simulations...
2016: PloS One
https://www.readbyqxmd.com/read/27799322/hyperglycaemia-in-infants-with-hypoxic-ischaemic-encephalopathy-is-associated-with-improved-outcomes-after-therapeutic-hypothermia-a-post-hoc-analysis-of-the-coolcap-study
#4
Sudeepta K Basu, Jason L Salemi, Alistair J Gunn, Jeffrey R Kaiser
OBJECTIVE: To investigate whether glycaemic profile is associated with multiorgan dysfunction and with response to hypothermia after perinatal hypoxic-ischaemic encephalopathy (HIE). DESIGN: Post hoc analysis of the CoolCap Study. SETTING: 25 perinatal centres in UK, USA and New Zealand during 1999-2002. PATIENTS: 194/234 (83%) infants of ≥36 weeks' gestation with moderate-to-severe HIE enrolled in the CoolCap Study with documented plasma glucose levels and follow-up outcome...
October 31, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27765442/-liability-for-loss-of-chance-in-neurological-conditions-in-the-spanish-public-healthcare-system
#5
Carlos Sardinero-García, Andrés Santiago-Sáez, M Del Carmen Bravo-Llatas, Bernardo Perea-Pérez, M Elena Albarrán-Juan, Elena Labajo-González, Julián Benito-León
OBJECTIVE: To analyse the sentences due to loss of chance that were passed by the Contentious-Administrative Court (i.e., in public medicine), in which both the origin of the disease to be treated and the damages were neurological. METHODS: We analysed the 90 sentences concerning neurological conditions that referred to the concept of loss of chance that were passed in Spain from 2003 (year of the first sentence) until May 2014. FINDINGS: Of the 90 sentences, 52 (57...
October 17, 2016: Gaceta Sanitaria
https://www.readbyqxmd.com/read/27726304/simulation-based-team-training-for-multi-professional-obstetric-care-teams-to-improve-patient-outcome-a-multicentre-cluster-randomised-controlled-trial
#6
A F Fransen, J van de Ven, E Schuit, Aac van Tetering, B W Mol, S G Oei
OBJECTIVE: To investigate whether simulation-based obstetric team training in a simulation centre improves patient outcome. DESIGN: Multicentre, open, cluster randomised controlled trial. SETTING: Obstetric units in the Netherlands. POPULATION: Women with a singleton pregnancy beyond 24 weeks of gestation. METHODS: Random allocation of obstetric units to a 1-day, multi-professional, simulation-based team training focusing on crew resource management (CRM) in a simulation centre or to no such team training...
October 10, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27704703/umbilical-lactate-as-a-measure-of-acidosis-and-predictor-of-neonatal-risk-a-systematic-review
#7
E R Allanson, T Waqar, Crh White, Ö Tunçalp, J E Dickinson
BACKGROUND: Umbilical cord lactate is one approach to measuring acidosis and intrapartum hypoxia, knowledge of which may be helpful for clinicians involved in the care of women and newborns. OBJECTIVE: To synthesise the evidence on accuracy of umbilical cord lactate in measuring acidosis and predicting poor neonatal outcome. SEARCH STRATEGY: Studies published and unpublished between 1990 and 2014 from PubMed/Medline, EMBASE, Cochrane Central Register of Controlled Trials, and clinicaltrials...
October 5, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27701803/eligibility-criteria-for-therapeutic-hypothermia-from-trials-to-clinical-practice
#8
Shailender Mehta, Anjali Joshi, Barbara Bajuk, Nadia Badawi, Sarah McIntyre, Kei Lui
AIM: Whole body therapeutic hypothermia (TH) for hypoxic ischaemic encephalopathy was introduced into clinical practice in New South Wales (NSW) and Australian Capital Territory in 2007. State-wide policy adopting the eligibility criteria and practice based on trial-designs was published in 2009. METHODS: The study was conducted by retrospectively reviewing medical records of all TH infants born between 2007 and 2011 in NSW and Australian Capital Territory to examine if eligibility criteria (assessed against evidence-based policy directives) were met...
October 4, 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27685816/timing-of-therapeutic-hypothermia-for-inborn-and-outborn-infants-with-neonatal-encephalopathy
#9
L Reaney, V Livingstone, C Bogue, E M Dempsey, P M Filan
Therapeutic hypothermia is now the standard of care for infants with moderate to severe hypoxic ischaemic encephalopathy. Sixty-three infants received therapeutic hypothermia at Cork University Maternity Hospital (CUMH) from 2010-2014. Median gestational age was 40 weeks. Eighteen (29%) infants were Sarnat grade 3, 41(65%) grade 2 and 4(6%) grade 1. Nineteen outborn infants arrived in CUMH at a median (IQR) age of 310 (270, 420) minutes. Four (21%) outborn infants were within the target temperature range on arrival...
2016: Irish Medical Journal
https://www.readbyqxmd.com/read/27549510/the-burden-of-hypoxic-ischaemic-encephalopathy-in-malaysian-neonatal-intensive-care-units
#10
Nem-Yun Boo, Irene Guat-Sim Cheah
INTRODUCTION: This study aimed to determine the incidence of hypoxic-ischaemic encephalopathy (HIE) and predictors of HIE mortality in Malaysian neonatal intensive care units (NICUs). METHODS: This was a retrospective study of data from 37 NICUs in the Malaysian National Neonatal Registry in 2012. All newborns with gestational age ≥ 36 weeks, without major congenital malformations and fulfilling the criteria of HIE were included. RESULTS: There were 285,454 live births in these hospitals...
August 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27540252/once-daily-gentamicin-dose-banding-in-newborns-with-signs-of-early-onset-of-neonatal-sepsis-eons-based-on-initial-birth-weight-and-gestational-age
#11
Paul-Michael Windscheif, Rhoda Welsh, Laura Smith, Ian Nicoll, Mark Anthony
AIM: Prospective assessment of safety of dose banding of once daily gentamicin in newborns with signs of EONS in their first days of life. METHOD: All neonates admitted on the level-3 neonatal unit, with at least three consecutive once daily gentamicin doses, started no later than 48 hrs after birth were included. The dose was based on initial birth weight and not adjusted to daily changes of the bodyweight(W). A gentamicin trough level of 2 mg/L was permitted...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27526141/interrelationship-between-broadband-nirs-measurements-of-cerebral-cytochrome-c-oxidase-and-systemic-changes-indicates-injury-severity-in-neonatal-encephalopathy
#12
Gemma Bale, Subhabrata Mitra, Isabel de Roever, Marcus Chan, Alexander Caicedo-Dorado, Judith Meek, Nicola Robertson, Ilias Tachtsidis
Perinatal hypoxic ischaemic encephalopathy (HIE) is associated with severe neurodevelopmental problems and mortality. There is a clinical need for techniques to provide cotside assessment of the injury extent. This study aims to use non-invasive cerebral broadband near-infrared spectroscopy (NIRS) in combination with systemic physiology to assess the severity of HIE injury. Broadband NIRS is used to measure the changes in haemodynamics, oxygenation and the oxidation state of cytochrome c oxidase (oxCCO). We used canonical correlation analysis (CCA), a multivariate statistical technique, to measure the relationship between cerebral broadband NIRS measurements and systemic physiology...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27486995/early-cord-metabolite-index-and-outcome-in-perinatal-asphyxia-and-hypoxic-ischaemic-encephalopathy
#13
C E Ahearne, N M Denihan, B H Walsh, S N Reinke, L C Kenny, G B Boylan, D I Broadhurst, D M Murray
BACKGROUND: A 1H-NMR-derived metabolomic index based on early umbilical cord blood alterations of succinate, glycerol, 3-hydroxybutyrate and O-phosphocholine has shown potential for the prediction of hypoxic-ischaemic encephalopathy (HIE) severity. OBJECTIVE: To evaluate whether this metabolite score can predict 3-year neurodevelopmental outcome in infants with perinatal asphyxia and HIE, compared with current standard biochemical and clinical markers. METHODS: From September 2009 to June 2011, infants at risk of perinatal asphyxia were recruited from a single maternity hospital...
2016: Neonatology
https://www.readbyqxmd.com/read/27423674/early-mri-in-neonatal-hypoxic-ischaemic-encephalopathy-treated-with-hypothermia-prognostic-role-at-2-year-follow-up
#14
Valérie Charon, Maïa Proisy, Gilles Bretaudeau, Bertrand Bruneau, Patrick Pladys, Alain Beuchée, Gladys Burnouf-Rose, Jean-Christophe Ferré, Céline Rozel
UNLABELLED: The prognostic role of early MRI (≤ 6 days of life) is still uncertain in hypoxic-ischaemic encephalopathy (HIE) treated with hypothermia. OBJECTIVE: To compare the prognostic value of early (≤ 6 days) and late MRIs (≥ 7 days) in predicting adverse outcome at 2 years old in asphyxiated term neonates treated with hypothermia. METHODS: This retrospective study included all asphyxiated neonates eligible for hypothermia treatment between November 2009 and July 2012...
August 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27370316/role-of-eeg-background-activity-seizure-burden-and-mri-in-predicting-neurodevelopmental-outcome-in-full-term-infants-with-hypoxic-ischaemic-encephalopathy-in-the-era-of-therapeutic-hypothermia
#15
Lauren C Weeke, Geraldine B Boylan, Ronit M Pressler, Boubou Hallberg, Mats Blennow, Mona C Toet, Floris Groenendaal, Linda S de Vries
OBJECTIVE: To investigate the role of EEG background activity, electrographic seizure burden, and MRI in predicting neurodevelopmental outcome in infants with hypoxic-ischaemic encephalopathy (HIE) in the era of therapeutic hypothermia. METHODS: Twenty-six full-term infants with HIE (September 2011-September 2012), who had video-EEG monitoring during the first 72 h, an MRI performed within the first two weeks and neurodevelopmental assessment at two years were evaluated...
December 0: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27368430/heart-rate-response-to-therapeutic-hypothermia-in-infants-with-hypoxic-ischaemic-encephalopathy
#16
Maja Elstad, Xun Liu, Marianne Thoresen
AIM OF THE STUDY: Neonatal encephalopathy (NE) of hypoxic-ischaemic origin may cause death or life-long disability which is reduced by therapeutic hypothermia (TH). Our objective was to assess HR response in infants undergoing TH after perinatal asphyxia. METHODS: We performed a retrospective case series, from a single-centre tertiary care NICU. We included ninety-two infants with NE of likely hypoxic-ischaemic origin, moderate or severe, treated with TH (n=60) or normothermia (n=32) who had 18 month outcome data and at least 12 HR recordings the first 24h after birth (1998-2010) Bristol, UK...
September 2016: Resuscitation
https://www.readbyqxmd.com/read/27337989/curved-reformat-of-the-paediatric-brain-mri-into-a-flat-earth-map-standardised-method-for-demonstrating-cortical-surface-atrophy-resulting-from-hypoxic-ischaemic-encephalopathy
#17
REVIEW
Ewan Simpson, Savvas Andronikou, Schadie Vedajallam, Anith Chacko, Ngoc Jade Thai
Hypoxic-ischaemic encephalopathy is optimally imaged with brain MRI in the neonatal period. However neuroimaging is often also performed later in childhood (e.g., when parents seek compensation in cases of alleged birth asphyxia). We describe a standardised technique for creating two curved reconstructions of the cortical surface to show the characteristic surface changes of hypoxic-ischaemic encephalopathy in children imaged after the neonatal period. The technique was applied for 10 cases of hypoxic-ischaemic encephalopathy and also for age-matched healthy children to assess the visibility of characteristic features of hypoxic-ischaemic encephalopathy...
September 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27336238/low-plasma-magnesium-is-associated-with-impaired-brain-metabolism-in-neonates-with-hypoxic-ischaemic-encephalopathy
#18
Elavazhagan Chakkarapani, Vann Chau, Kenneth J Poskitt, Anne Synnes, Eddie Kwan, Elke Roland, Steven P Miller
AIM: To determine the association between lowest plasma magnesium concentration and brain metabolism, and whether magnetic resonance imaging brain injury patterns moderated the association in hypoxic-ischemic encephalopathy. METHODS: In 131 early (day-of-life 3) and 65 late (day-of-life 10) scans of term encephalopathic infants born between 2004 and 2012, we examined the association of lowest plasma magnesium (until day-of-life 3) on basal ganglia and white matter peak metabolite ratios on magnetic resonance spectroscopy independent of covariates, stratified by the predominant patterns of injury (normal, basal nuclei/total, watershed, multifocal) using multiple linear regression...
September 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27302388/the-association-between-antioxidant-enzyme-polymorphisms-and-cerebral-palsy-after-perinatal-hypoxic-ischaemic-encephalopathy
#19
Katarina Esih, Katja Goričar, Vita Dolžan, Zvonka Rener-Primec
BACKGROUND: Hypoxic-ischaemic perinatal brain injury leads to the formation of reactive oxygen species (ROS) and the resultant cell and tissue damage may cause neurological sequelae such as cerebral palsy and/or epilepsy. A decrease in the capacity for defending against ROS may increase the susceptibility to cerebral palsy. The aim of this study was to investigate the impact of common functional polymorphisms in the antioxidant genes SOD2, GPX1 and CAT, associated with a decreased capacity for defending against ROS, in patients with perinatal hypoxic-ischaemic encephalopathy (HIE)...
December 0: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27302243/gestational-hypertensive-disease-in-twin-pregnancy-influence-on-outcomes-in-a-large-national-prospective-cohort
#20
Mark P Hehir, Fionnuala M Breathnach, Fionnuala M McAuliffe, Michael P Geary, Sean Daly, John Higgins, Alyson Hunter, John J Morrison, Gerard Burke, Shane Higgins, Rhona Mahony, Patrick Dicker, Elizabeth C Tully, Fergal D Malone
OBJECTIVE: Gestational hypertensive disease (GHD) is associated with pregnancy-related complications and poor maternal and fetal outcomes in singleton pregnancies. We sought to examine the influence of GHD in a large prospective cohort of twin pregnancies. STUDY DESIGN: The ESPRIT study was a national multicenter observational cohort study of 1028 structurally normal twin pregnancies. Each pregnancy underwent sonographic surveillance with two-week ultrasound from 24 weeks for dichorionic and from 16 weeks for monochorionic gestations...
June 15, 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
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