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Hypoxic ischaemic encephalopathy

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https://www.readbyqxmd.com/read/29451698/the-ketogenic-diet-is-effective-for-refractory-epilepsy-associated-with-acquired-structural-epileptic-encephalopathy
#1
Mel Michel Villaluz, Lysa Boissé Lomax, Trupti Jadhav, J Helen Cross, Ingrid E Scheffer
AIM: Ketogenic diet therapies have proven efficacy for refractory epilepsy. There are many reports of their use in the genetic developmental and epileptic encephalopathies; however, little attention has been paid as to whether the diet is also effective in individuals with an acquired structural aetiology. We observed remarkable efficacy of the diet in two patients with hypoxic-ischaemic encephalopathy. We then analysed our cases with refractory structural epilepsies of acquired origin to characterize their response to the ketogenic diet...
February 16, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29426351/poly-arginine-r18-and-r18d-d-enantiomer-peptides-reduce-infarct-volume-and-improves-behavioural-outcomes-following-perinatal-hypoxic-ischaemic-encephalopathy-in-the-p7-rat
#2
Adam B Edwards, Jane L Cross, Ryan S Anderton, Neville W Knuckey, Bruno P Meloni
We examined the neuroprotective efficacy of the poly-arginine peptide R18 and its D-enantiomer R18D in a perinatal hypoxic-ischaemic (HI) model in P7 Sprague-Dawley rats. R18 and R18D peptides were administered intraperitoneally at doses of 30, 100, 300 or 1000 nmol/kg immediately after HI (8% O2/92%N2 for 2.5 h). The previously characterised neuroprotective JNKI-1-TATD peptide at a dose of 1000 nmol/kg was used as a control. Infarct volume and behavioural outcomes were measured 48 h after HI. For the R18 and R18D doses examined, total infarct volume was reduced by 25...
February 9, 2018: Molecular Brain
https://www.readbyqxmd.com/read/29369068/applications-of-near-infrared-spectroscopy-in-the-neonate
#3
Aisling A Garvey, Eugene M Dempsey
PURPOSE OF REVIEW: There has been a significant increase in the utilization of NIRS in neonatal care over the last few years, with some centers now routinely utilizing this monitoring technique for direct intervention at the bedside. In this review, we provide a summary of the most up-to-date evidence on near infrared spectroscopy utilization, with particular emphasis on measurement of cerebral oxygenation in preterm infants. RECENT FINDINGS: There have been significant advances in the technology, leading to an increase in the number of available devices and in the use of this monitoring tool to reduce cerebral injury in preterm infants...
January 22, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29366907/electrodiagnostic-applications-of-somatosensory-evoked-high-frequency-eeg-oscillations-technical-considerations
#4
A J Simpson, M O Cunningham, M R Baker
INTRODUCTION: High frequency oscillations (HFOs) embedded within the somatosensory evoked potential (SEP) are not routinely recorded/measured as part of standard clinical SEPs. However, HFOs could provide important additional diagnostic/prognostic information in various patient groups in whom SEPs are tested routinely. One area is the management of patients with hypoxic ischaemic encephalopathy (HIE) in the intensive care unit (ICU). However, the sensitivity of standard clinical SEP recording techniques for detecting HFOs is unknown...
January 20, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29318658/does-erythropoietin-monotherapy-reduce-mortality-or-moderate-severe-disability-in-neonates-with-hypoxic-ischaemic-encephalopathy
#5
Joseph S Bircher, Dmitry Dukhovny
No abstract text is available yet for this article.
January 9, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29301489/intrapartum-fetal-deaths-and-unexpected-neonatal-deaths-in-the-republic-of-ireland-2011-2014-a-descriptive-study
#6
K McNamara, K O'Donoghue, R A Greene
BACKGROUND: Intrapartum fetal death, the death of a fetus during labour, is a tragic outcome of pregnancy. The intrapartum death rate of a country is reflective of the care received by mothers and babies in labour and it is through analysing these cases that good aspects of care, as well as areas for improvement can be identified. Investigating unexpected neonatal deaths that may be associated with an intrapartum event is also helpful to fully appraise intrapartum care. This is a descriptive study of intrapartum fetal deaths and unexpected neonatal deaths in Ireland from 2011 to 2014...
January 4, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29241628/-care-of-the-newborn-with-perinatal-asphyxia-candidate-for-therapeutic-hypothermia-during-the-first-six-hours-of-life-in-spain
#7
Juan Arnaez, Alfredo Garcia-Alix, Sara Calvo, Simón Lubián-López
INTRODUCTION: The process of care and assistance from birth to the starting of therapeutic hypothermia (TH) is crucial in order to improve its effectiveness and prevent the worsening of hypoxic-ischaemic injury. METHODS: A national cross-sectional study carried out in 2015 by use of a questionnaire sent to all level iii units on the care of the newborn≥35 weeks gestation within the first hours of life after a perinatal asphyxia event. According to clinical practice guidelines, the quality of care was compared between the hospitals that carried out or did not carry out TH, and according to the level of care...
December 11, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29213143/lactate-as-an-early-predictor-of-psychomotor-development-in-neonates-with-asphyxia-receiving-therapeutic-hypothermia
#8
Renata Polackova, Dana Salounova, Lumir Kantor
AIMS: This prospective study aimed to evaluate the relationship between persistently elevated lactate values in the arterial blood of newborns with grade II and III hypoxic ischemic encephalopathy (treated with therapeutic hypothermia) and psychomotor development at 24 months. METHODS: 51 neonates of gestational age from 36 to 41 weeks receiving therapeutic hypothermia for moderate to severe hypoxic ischaemic encephalopathy had arterial blood lactate levels regularly analysed...
December 4, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29196306/perinatal-infratentorial-haemorrhage-a-rare-but-possibly-life-threatening-condition
#9
Bettina Cornelia Henzi, Bendicht Wagner, Rajeev Kumar Verma, Sandra Bigi
BACKGROUND: Perinatal infratentorial haemorrhage (PIH) is a rare birth complication associated with abnormal labour. CASE PRESENTATION: A baby boy was born by vacuum extraction at 41 weeks' gestational age. The pregnancy was uneventful and Apgar scores were 3/6/9. Following initial resuscitation, insufficient and irregular breathing, non-reactive pupils and absence of spontaneous movements were noted. A diagnosis of perinatal asphyxia with hypoxic-ischaemic encephalopathy (HIE) was considered...
December 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29180541/neonatal-brain-injuries-in-england-population-based-incidence-derived-from-routinely-recorded-clinical-data-held-in-the-national-neonatal-research-database
#10
Chris Gale, Yevgeniy Statnikov, Sena Jawad, Sabita N Uthaya, Neena Modi
OBJECTIVE: In 2015, the Department of Health in England announced an ambition to reduce 'brain injuries occurring during or soon after birth'. We describe the development of a pragmatic case definition and present annual incidence rates. DESIGN: Retrospective cohort study using data held in the National Neonatal Research Database (NNRD) extracted from neonatal electronic patient records from all National Health Service (NHS) neonatal units in England, Wales and Scotland...
October 22, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29171918/asphyxiated-neonates-who-received-active-therapeutic-hypothermia-during-transport-had-higher-rates-of-hypocapnia-than-controls
#11
Eniko Szakmar, Kata Kovacs, Unoke Meder, Geza Bokodi, Andras Szell, Zsolt Somogyvari, Attila J Szabo, Miklos Szabo, Agnes Jermendy
AIM: We investigated the association between active hypothermia and hypocapnia in neonates with moderate to severe hypoxic-ischaemic encephalopathy (HIE) transported after birth. METHODS: This was a retrospective cohort study of neonates with HIE born between 2007-2011 and transported to Semmelweis University, Hungary, for hypothermia treatment before and after we introduced active cooling during transport in 2009. Of these, 71 received intensive care plus controlled active hypothermia during transport, while the 46 controls just received standard intensive care...
November 24, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29056588/neonatal-brain-injuries-in-england-population-based-incidence-derived-from-routinely-recorded-clinical-data-held-in-the-national-neonatal-research-database
#12
Chris Gale, Yevgeniy Statnikov, Sena Jawad, Sabita N Uthaya, Neena Modi
OBJECTIVE: In 2015, the Department of Health in England announced an ambition to reduce 'brain injuries occurring during or soon after birth'. We describe the development of a pragmatic case definition and present annual incidence rates. DESIGN: Retrospective cohort study using data held in the National Neonatal Research Database (NNRD) extracted from neonatal electronic patient records from all National Health Service (NHS) neonatal units in England, Wales and Scotland...
October 22, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28940525/estimation-of-initial-phenobarbital-dosing-in-term-neonates-with-moderate-to-severe-hypoxic-ischaemic-encephalopathy-following-perinatal-asphyxia
#13
M Šíma, P Pokorná, J Hartinger, O Slanař
WHAT IS KNOWN AND OBJECTIVE: Phenobarbital is the first-line treatment of seizures in asphyxiated neonates; however, due to the high pharmacokinetic variability in this population, there is no consensus on the optimal dosage regimen. This study was conducted to identify variables that affect phenobarbital fate during routine clinical care and then to evaluate the dosage schedule that could be applied in term asphyxiated neonates with respect to achieving the target therapeutic range. METHODS: Phenobarbital pharmacokinetics was calculated based on serum concentrations measurements using one-compartmental model...
September 22, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28939695/oxidative-stress-and-endoplasmic-reticulum-er-stress-in-the-development-of-neonatal-hypoxic-ischaemic-brain-injury
#14
REVIEW
Claire Thornton, Ana A Baburamani, Anton Kichev, Henrik Hagberg
Birth asphyxia in term neonates affects 1-2/1000 live births and results in the development of hypoxic-ischaemic encephalopathy with devastating life-long consequences. The majority of neuronal cell death occurs with a delay, providing the potential of a treatment window within which to act. Currently, treatment options are limited to therapeutic hypothermia which is not universally successful. To identify new interventions, we need to understand the molecular mechanisms underlying the injury. Here, we provide an overview of the contribution of both oxidative stress and endoplasmic reticulum stress in the development of neonatal brain injury and identify current preclinical therapeutic strategies...
October 15, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28893058/serratia-marcescens-infection-or-hypoxic-ischaemic-encephalopathy-in-neonates-is-magnetic-resonance-imaging-a-problem-solving-tool
#15
D Narese, C Auriti, D Longo
No abstract text is available yet for this article.
May 1, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28845537/cerebral-blood-flow-velocities-and-cerebrovascular-resistance-in-normal-term-neonates-in-the-first-72-hours
#16
Danielle E Forster, Emmanuel Koumoundouros, Virginia Saxton, Gabrielle Fedai, James Holberton
AIM: To determine the range of cerebral blood flow velocities (CBFVs) and Doppler indices of cerebrovascular resistance in normal-term neonates as a baseline for a study of hypoxic-ischaemic encephalopathy. METHODS: The CBFVs, resistive index (RI) and pulsatility index (PI) were measured in the anterior and middle cerebral arteries (ACA and MCA) of 38 normal neonates. RESULTS: The mean peak systolic, end diastolic and time-averaged velocities (PSV, EDV and TAV) were 36...
August 28, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28844055/what-is-mr-spectroscopy
#17
Karen Angela Manias, Andrew Peet
(1)H-Magnetic Resonance Spectroscopy (MRS) is a novel advanced imaging technique used as an adjunct to MRI to reveal complementary non-invasive information about the biochemical composition of imaged tissue. Clinical uses in paediatrics include aiding diagnosis of brain tumours, neonatal disorders such as hypoxic-ischaemic encephalopathy, inherited metabolic diseases, traumatic brain injury, demyelinating conditions and infectious brain lesions. MRS has potential to improve diagnosis and treatment monitoring of childhood brain tumours and other CNS diseases, facilitate biopsy and surgical planning, and provide prognostic biomarkers...
August 26, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28840775/untargeted-metabolomic-analysis-and-pathway-discovery-in-perinatal-asphyxia-and-hypoxic-ischaemic-encephalopathy
#18
Niamh M Denihan, Jennifer A Kirwan, Brian H Walsh, Warwick B Dunn, David I Broadhurst, Geraldine B Boylan, Deirdre M Murray
Elucidating metabolic effects of hypoxic-ischaemic encephalopathy (HIE) may reveal early biomarkers of injury and new treatment targets. This study uses untargeted metabolomics to examine early metabolic alterations in a carefully defined neonatal population. Infants with perinatal asphyxia who were resuscitated at birth and recovered (PA group), those who developed HIE (HIE group) and healthy controls were all recruited at birth. Metabolomic analysis of cord blood was performed using direct infusion FT-ICR mass spectrometry...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28764944/-incidence-of-hypoxic-ischaemic-encephalopathy-and-use-of-therapeutic-hypothermia-in-spain
#19
Juan Arnaez, Alfredo García-Alix, Gemma Arca, Eva Valverde, Sonia Caserío, M Teresa Moral, Isabel Benavente-Fernández, Simón Lubián-López
INTRODUCTION: There are no data on the incidence of hypoxic-ischaemic encephalopathy (HIE) and the implementation of therapeutic hypothermia (TH) in Spain. METHODS: This is a cross-sectional, national study, performed using an on-line questionnaire targeting level III neonatal care units in Spain. Participants were requested to provide data of all newborns ≥ 35 weeks of gestational age diagnosed with moderate-severe HIE over a two year-period (2012-2013), and of the implementation of TH up to June 2015...
July 29, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28743959/continual-conscious-bioluminescent-imaging-in-freely-moving-somatotransgenic-mice
#20
Rajvinder Karda, Dany P Perocheau, Natalie Suff, Joanne Ng, Juliette M K M Delhove, Suzanne M K Buckley, Samantha Richards, John R Counsell, Henrik Hagberg, Mark R Johnson, Tristan R McKay, Simon N Waddington
Luciferase bioimaging in living animals is increasingly being applied in many fields of biomedical research. Rodent imaging usually involves anaesthetising the animal during data capture, however, the biological consequences of anaesthesia have been largely overlooked. We have evaluated luciferase bioimaging in conscious, unrestrained mice after neonatal intracranial or intravascular administration of lentiviral, luciferase reporter cassettes (biosensors); we present real-time analyses from the first day of life to adulthood...
July 25, 2017: Scientific Reports
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