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First episode psychosis

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https://www.readbyqxmd.com/read/28634088/duration-of-untreated-psychosis-and-neurocognition-in-first-episode-psychosis-a-meta-analysis
#1
REVIEW
Emre Bora, Berna Yalincetin, Berna Binnur Akdede, Koksal Alptekin
Neurocognitive impairment is a well-established feature of first-episode psychosis (FEP). Neurotoxicity hypothesis of psychosis suggests that untreated psychosis before the initiation of first effective treatment is associated with loss of acquired cognitive abilities. However, the outcome of the studies investigating the relationship between duration of untreated psychosis (DUP) and cognitive impairment in FEP remains inconclusive. No previous meta-analysis investigating the relationship between DUP and cognitive impairment in FEP has been published...
June 17, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28627459/peripheral-blood-gene-expression-of-acute-phase-proteins-in-people-with-first-episode-psychosis
#2
Jie Yin Yee, Milawaty Nurjono, Wai Yee Ng, Stephanie Ruth Teo, Tih-Shih Lee, Jimmy Lee
BACKGROUND: There is a growing interest in the association between schizophrenia and the activation of inflammatory system with signs of acute phase (AP) response. Majority of such studies had focused on C-reactive protein (CRP). The aims of the present study were (i) to examine the gene expression profiles of other acute phase proteins (APP), namely haptoglobin (HP), alpha-1 antitrypsin (A1T), and alpha-2 macroglobulin (A2M) in patients with first episode psychosis (FEP) over a period of three months and (ii) to explore the association between APP levels and severity of symptoms...
June 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28625185/deterioration-of-visuospatial-associative-memory-following-a-first-psychotic-episode-a-long-term-follow-up-study
#3
C M J Wannan, C F Bartholomeusz, V L Cropley, T E Van Rheenen, A Panayiotou, W J Brewer, T M Proffitt, L Henry, M G Harris, D Velakoulis, P McGorry, C Pantelis, S J Wood
BACKGROUND: Cognitive deficits are a core feature of schizophrenia, and impairments in most domains are thought to be stable over the course of the illness. However, cross-sectional evidence indicates that some areas of cognition, such as visuospatial associative memory, may be preserved in the early stages of psychosis, but become impaired in later established illness stages. This longitudinal study investigated change in visuospatial and verbal associative memory following psychosis onset...
June 19, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28622570/the-role-of-premorbid-personality-and-social-cognition-in-suicidal-behaviour-in-first-episode-psychosis-a-one-year-follow-up-study
#4
Manuel Canal-Rivero, J D Lopez-Moriñigo, M L Barrigón, S Perona-Garcelán, C Jimenez-Casado, A S David, J E Obiols-Llandrich, M Ruiz-Veguilla
BACKGROUND: High suicide attempt (SA) rates have been reported in first-episode psychosis (FEP) patients, particularly during the first year after the illness onset. Despite previous studies establishing several risk factors for suicidal behaviour in FEP, premorbid personality and social cognition have not been sufficiently investigated to date. OBJECTIVE: To test whether personality traits and social cognition are associated with SAs in FEP over a 12-month follow-up...
May 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28620812/case-study-of-first-episode-schizophrenia-in-pregnancy-and-postpartum
#5
Kristopher A Kast, Smita Agarkar
Patients with first-episode psychosis of peripartum onset commonly prove to have a mood-disorder diathesis; however, a proportion of cases represent first-episode schizophrenia. We present such a case and discuss the clinical relevance of recognizing this small but important population of new mothers. These patients are at considerable risk of misdiagnosis, resulting in ineffective maintenance therapy, poorer recovery of function, and development of treatment resistance. Accurate diagnosis in the peripartum period will impact treatment decisions and long-term therapy...
June 15, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28617204/is-the-clinical-high-risk-state-a-valid-concept-retrospective-examination-in-a-first-episode-psychosis-sample
#6
Jai L Shah, Anne Crawford, Sally S Mustafa, Srividya N Iyer, Ridha Joober, Ashok K Malla
OBJECTIVE: One reason for worldwide interest in the clinical high-risk (CHR) state for psychosis is its potential as a target for prevention. However, the feasibility and utility of early intervention initiatives that are focused on this stage involve an untested assumption: that most patients with a first episode of psychosis (FEP) experience earlier CHR symptoms. The objective of this study was to identify and characterize the proportion of FEP patients who had experienced such symptoms prior to the onset of their psychosis...
June 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28613411/outcome-in-patients-converting-to-psychosis-following-a-treated-clinical-high-risk-state
#7
Ashok Malla, Marianne de Bonneville, Jai Shah, Gerald Jordan, Marita Pruessner, Kia Faridi, Mark Rabinovitch, Srividya N Iyer, Ridha Joober
AIM: We explored 2-year outcomes in a sample of clinical high risk (CHR) patients who converted to psychosis despite receiving interventions. METHODS: Of 167 CHR patients, 18 had converted to psychosis and received treatment for their first episode of psychosis in an early intervention service over 2 years. RESULTS: Compared to patients admitted directly to the same early intervention service without having been identified as CHR prior to onset of psychosis, CHR converters were in remission for fewer months (M = 5 vs M = 10); were more likely to be prescribed more than 1 antipsychotic medication (90% vs 68%) and to receive clozapine treatment (38% vs 2%) over 2 years...
June 14, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28602647/state-marker-properties-of-niacin-skin-sensitivity-in-ultra-high-risk-groups-for-psychosis-an-optical-reflection-spectroscopy-study
#8
Kerstin Langbein, Ulrike Schmidt, Stephan Schack, Natalie J Biesel, Maria Rudzok, G Paul Amminger, Maximus Berger, Heinrich Sauer, Stefan Smesny
Impaired niacin sensitivity (NS) is one of the most replicated findings in untreated schizophrenia, and reflects a disturbance of prostaglandin-mediated pathways in association with deregulated arachidonic acid metabolism, pro-inflammatory activation, and vasomotor function. In ultra-high risk individuals (UHR) increased NS was reported recently, pointing towards dynamic alterations of the underlying pathomechanisms in the period preceding psychosis. However, these characteristics are still unresolved in the diverse UHR groups...
June 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28602144/antipsychotic-treatment-experiences-of-fully-recovered-service-users
#9
Jone Bjornestad, Larry Davidson, Inge Joa, Tor Ketil Larsen, Wenche Ten Velden Hegelstad, Johannes Langeveld, Marius Veseth, Ingrid Melle, Jan Olav Johannessen, Kolbjorn Bronnick
BACKGROUND: There is lack of long-term controlled studies evaluating treatment effects of antipsychotic medication. A complete investigation should include the service user perspective. AIMS: To investigate experiences of clinically recovered service users of antipsychotic medications during and after a first episode of psychosis. METHOD: We used a thematic analytic approach within an interpretative-phenomenological framework. 20 clinically recovered service users were interviewed...
June 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28601943/examining-the-impact-of-migrant-status-on-ethnic-differences-in-mental-health-service-use-preceding-a-first-diagnosis-of-schizophrenia
#10
Kelly K Anderson, Kwame J McKenzie, Paul Kurdyak
PURPOSE: Some ethnic groups have more negative contacts with health services for first-episode psychosis, likely arising from a complex interaction between ethnicity, socio-economic factors, and immigration status. Using population-based health administrative data, we sought to examine the effects of ethnic group and migrant status on patterns of health service use preceding a first diagnosis of schizophrenia or schizoaffective disorder among people aged 14-35 over a 10-year period. METHODS: We compared access to care and intensity of service use for first-generation ethnic minority groups to the general population of Ontario...
June 10, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28601717/duration-of-untreated-psychosis-illness-and-brain-volume-changes-in-early-psychosis
#11
Charlotte Rapp, Carlos Canela, Erich Studerus, Anna Walter, Jacqueline Aston, Stefan Borgwardt, Anita Riecher-Rössler
The time period during which patients manifest psychotic or unspecific symptoms prior to treatment (duration of untreated psychosis, DUP, and the duration of untreated illness, DUI) has been found to be moderately associated with poor clinical and social outcome. Equivocal evidence exists of an association between DUP/DUI and structural brain abnormalities, such as reduced hippocampus volume (HV), pituitary volume (PV) and grey matter volume (GMV). Thus, the goal of the present work was to examine if DUP and DUI are associated with abnormalities in HV, PV and GMV...
June 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28599949/quetiapine-extended-release-versus-aripiprazole-in-children-and-adolescents-with-first-episode-psychosis-the-multicentre-double-blind-randomised-tolerability-and-efficacy-of-antipsychotics-tea-trial
#12
Anne Katrine Pagsberg, Pia Jeppesen, Dea Gowers Klauber, Karsten Gjessing Jensen, Ditte Rudå, Marie Stentebjerg-Olesen, Peter Jantzen, Simone Rasmussen, Eva Ann-Sofie Saldeen, Maj-Britt Glenn Lauritsen, Niels Bilenberg, Anne Dorte Stenstrøm, Louise Nyvang, Sarah Madsen, Thomas M Werge, Theis Lange, Christian Gluud, Maria Skoog, Per Winkel, Jens Richardt M Jepsen, Birgitte Fagerlund, Christoph U Correll, Anders Fink-Jensen
BACKGROUND: Head-to-head trials to guide antipsychotic treatment choices for paediatric psychosis are urgently needed because extrapolations from adult studies might not be implementable. In this superiority trial with two-sided significance testing, we aimed to compare the efficacy and safety of quetiapine-extended release (quetiapine-ER) versus aripiprazole in children and adolescents with first-episode psychosis, to determine whether differences between the two treatments were sufficient to guide clinicians in their choice of one drug over the other...
June 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28597553/attenuated-positive-psychotic-symptoms-and-the-experience-of-anhedonia
#13
Shanna Cooper, Ann M Kring, Lauren M Ellman
BACKGROUND: Deficits in anticipatory pleasure have been consistently shown among chronic, first-episode, and clinical high risk for psychosis populations, but much less attention has been given to non-clinical individuals experiencing attenuated positive psychotic symptoms (APPS). METHODS: Young adults (N = 1839) were administered the Temporal Experience of Pleasure Scale, which measures anticipatory and consummatory pleasure, and the Prodromal Questionnaire, which measures APPS...
June 9, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28591137/increasing-medication-adherence-and-income-assistance-access-for-first-episode-psychosis-patients
#14
Jason Randall, Dan Chateau, James M Bolton, Mark Smith, Laurence Katz, Elaine Burland, Carole Taylor, Nathan C Nickel, Jennifer Enns, Alan Katz, Marni Brownell
BACKGROUND: Assertive community treatment for first-episode psychosis programs have been shown to improve symptoms and reduce service use. There is little or no evidence on whether these programs can increase access to income assistance and improve medication adherence in first episode psychosis patients. This research examines the impact of the Early Psychosis Prevention and Intervention Service (EPPIS) on these outcomes. METHODS: We extracted data on EPPIS patients held in the Data Repository at the Manitoba Centre for Health Policy...
2017: PloS One
https://www.readbyqxmd.com/read/28588522/the-positive-and-negative-experiences-of-caregiving-for-siblings-of-young-people-with-first-episode-psychosis
#15
Siann Bowman, Mario Alvarez-Jimenez, Darryl Wade, Linsey Howie, Patrick McGorry
Background: The impact of first episode psychosis (FEP) upon parents' experience of caregiving has been well-documented. However, the determinants and nature of this remain poorly understood in siblings. It is hypothesized that siblings of young people with FEP are also impacted by caregiving and burden. This study aimed to characterize the experience of caregiving for siblings of young people with FEP. Method: Survey methodology was used to explore the experience of 157 siblings in the first 18 months of their brother or sister's treatment for FEP...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28588514/pathways-from-trauma-to-psychotic-experiences-a-theoretically-informed-model-of-posttraumatic-stress-in-psychosis
#16
Amy Hardy
In recent years, empirical data and theoretical accounts relating to the relationship between childhood victimization and psychotic experiences have accumulated. Much of this work has focused on co-occurring Posttraumatic Stress Disorder or putative causal mechanisms in isolation from each other. The complexity of posttraumatic stress reactions experienced in psychosis remains poorly understood. This paper therefore attempts to synthesize the current evidence base into a theoretically informed, multifactorial model of posttraumatic stress in psychosis...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28587701/brain-atrophy-is-a-frequent-finding-in-elderly-patients-with-first-episode-psychosis
#17
Ulla-Marja Louhija, Tuula Saarela, Kati Juva, Björn Appelberg
BACKGROUND: To characterize the yearly incidence, diagnostic distribution, and neuro-radiologic findings in patients aged over 60 years, referred to psychiatric treatment with first episode psychosis (FEP). METHODS: A computerized search, including all patients referred to psychiatric treatment during 12 consecutive months with a de novo diagnosis of psychosis was performed in the Helsinki region catchment area with 1.2 million inhabitants. Diagnoses based on hospital records were made by a group of one neurologist and three psychiatrists...
June 7, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28584649/adherence-to-nice-guidance-on-lifestyle-advice-for-people-with-schizophrenia-a-survey
#18
Lizzie Swaby, Daniel Hind, Rebecca Gossage-Worrall, David Shiers, Jonathan Mitchell, Richard I G Holt
Aims and method The STEPWISE trial (STructured lifestyle Education for People WIth SchizophrEnia, schizoaffective disorder and first episode psychosis) is currently evaluating a lifestyle education programme in addition to usual care. However, it is difficult to define what constitutes 'usual care'. We aimed to define 'usual care' for lifestyle management in people with schizophrenia, schizoaffective disorder and first-episode psychosis in STEPWISE study sites. Ten National Health Service (NHS) mental health trusts participated in a bespoke survey based on the National Institute for Health and Care Excellence (NICE) guidance...
June 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28578812/determinants-of-duration-of-untreated-psychosis-among-first-episode-psychosis-patients-in-denmark-a-nationwide-register-based-study
#19
Lene Halling Hastrup, Ulrik Helt Haahr, Jens Einar Jansen, Erik Simonsen
BACKGROUND: Information on determinants of duration of untreated psychosis (DUP) is still needed to inform campaigns targeting people with first episode psychosis (FEP). This nation-wide study analysed the association between demographic factors (age, sex, ethnicity, marital status, and geographic area), premorbid and illness-related factors (global functional level, substance misuse, and contact to police), healthcare factors (referral source and first FEP contact) and DUP. METHOD: The study population of 1266 patients aged 15-25years diagnosed with FEP (ICD10 F20...
May 31, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28578180/-with-a-little-help-from-my-friends-social-predictors-of-clinical-recovery-in-first-episode-psychosis
#20
Jone Bjornestad, Wenche Ten Velden Hegelstad, Inge Joa, Larry Davidson, Tor Ketil Larsen, Ingrid Melle, Marius Veseth, Jan Olav Johannessen, Kolbjorn Bronnick
Social functioning is a conglomerate of factors central to clinical recovery after a first-episode psychosis. There is a lack of studies investigating the relative impact of factors related to social interaction. Disentangling these could facilitate improvement of psychosocial interventions. This study aims to investigate the impact of social interactions on two-year clinical recovery in first-episode psychosis, by examining frequency and satisfaction of relationships with family and friends. A baseline sample of 178 first-episode psychosis individuals were followed up over two years regarding social functioning and clinical status...
May 30, 2017: Psychiatry Research
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