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First episode psychosis

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https://www.readbyqxmd.com/read/27899309/repeated-misdiagnosis-of-a-relapsed-atypical-anti-nmda-receptor-encephalitis-without-an-associated-ovarian-teratoma
#1
Weihe Zhang, Li Yan, Jinsong Jiao
We present an atypical case of relapsed anti-NMDAR encephalitis in a young female patient without an associated ovarian teratoma. She presented with recurrent seizure attacks with muscle weakness, psychosis, dyskinesia, autonomic failure and insomnia. She was first misdiagnosed as mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) then Hashimoto's encephalopathy due to diffuse cerebral lesions, elevated serum lactic acid concentration, increased amount of thyroid peroxidase and thyroglobulin antibodies in serum and diffuse lesions of the thyroid gland...
November 26, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27898324/longitudinal-trajectory-of-clinical-insight-and-covariation-with-cortical-thickness-in-first-episode-psychosis
#2
Lisa Buchy, Carolina Makowski, Ashok Malla, Ridha Joober, Martin Lepage
Among people with a first-episode of psychosis, those with poorer clinical insight show neuroanatomical abnormalities in frontal, temporal and parietal cortices compared to those with better clinical insight. Whether changes in clinical insight are associated with progressive structural brain changes is unknown. We aimed to evaluate 1) associations between clinical insight and cortical thickness at a baseline assessment, 2) covariation between clinical insight and cortical thickness across baseline, one-year and two-year follow-up assessments, and 3) the predictive value of clinical insight for cortical thickness at one-year and two-year follow-ups...
November 19, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27888973/comparison-of-caregiver-burden-in-first-episode-versus-chronic-psychosis
#3
Perihan Sagut, Zekiye Çetinkaya Duman
The aim of this study was to compare burden on caregivers of patients with first episode psychosis and caregivers of those with chronic psychosis. The study sample consisted of 39 caregivers of patients with first episode psychosis and 40 caregivers of patients with chronic psychosis. The Caregiver Burden Inventory (CBI) was used for data collection. The average caregiver burden in caregivers of patients with chronic psychosis was significantly higher than that in caregivers of patients with first episode psychosis...
December 2016: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/27888680/symptomatic-and-functional-outcomes-of-substance-use-disorder-persistence-2-years-after-admission-to-a-first-episode-psychosis-program
#4
Amal Abdel-Baki, Clairélaine Ouellet-Plamondon, Émilie Salvat, Kawthar Grar, Stéphane Potvin
Substance use disorders (SUD) in first-episode psychosis (FEP) are highly prevalent and linked with poor outcomes. However, most longitudinal studies investigating their impacts in FEP have not reported proportions of patients who ceased SUD. Our aim was to examine the influence of SUD course on functional and symptomatic outcomes as well as service use in FEP. We performed a 2-year longitudinal study of 212 FEP patients, aged between 18 and 30 years, admitted to 2 early psychosis services in Montréal, Québec, Canada...
November 10, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27886071/case-formulation-in-young-people-with-post-traumatic-stress-disorder-and-first-episode-psychosis
#5
Emma Halpin, Vanessa Kugathasan, Carol Hulbert, Mario Alvarez-Jimenez, Sarah Bendall
BACKGROUND: Evidence based treatment interventions for young people with first-episode psychosis (FEP) and trauma histories is lacking. Although case formulation (CF) has been widely regarded in cognitive behavioural therapy manuals as beneficial, there is limited empirical research examining how clients and therapists experience the process. AIM: This study aimed to explore young people's reactions to CF in treatment for PTSD (post-traumatic stress disorder) and FEP...
November 23, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27877101/from-molecules-to-the-clinic-linking-schizophrenia-and-metabolic-syndrome-through-sphingolipids-metabolism
#6
REVIEW
Rolando I Castillo, Leonel E Rojo, Marcela Henriquez-Henriquez, Hernán Silva, Alejandro Maturana, María J Villar, Manuel Fuentes, Pablo A Gaspar
Metabolic syndrome (MS) is a prevalent and severe comorbidity observed in schizophrenia (SZ). The exact nature of this association is controversial and very often accredited to the effects of psychotropic medications and disease-induced life-style modifications, such as inactive lifestyle, poor dietary choices, and smoking. However, drug therapy and disease-induced lifestyle factors are likely not the only factors contributing to the observed converging nature of these conditions, since an increased prevalence of MS is also observed in first episode and drug-naïve psychosis populations...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27872587/the-association-between-anomalous-self-experiences-self-esteem-and-depressive-symptoms-in-first-episode-schizophrenia
#7
Elisabeth Haug, Merete G Øie, Ole A Andreassen, Unni Bratlien, Kristin L Romm, Paul Møller, Ingrid Melle
Background: Anomalous self-experiences (ASEs) aggregate in schizophrenia spectrum disorders, but the relationship between ASEs, and depression has been studied to a limited extent. Lower self-esteem has been shown to be associated with depression in early psychosis. Our hypothesis is that ASEs in early phases of schizophrenia are linked to lower levels of self-esteem, which in turn is associated with depression. Aim: The aim is to examine the relationship between ASEs, self-esteem and depression in first-episode schizophrenia spectrum disorders...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27869058/relationship-of-amotivation-to-neurocognition-self-efficacy-and-functioning-in-first-episode-psychosis-a-structural-equation-modeling-approach
#8
W C Chang, V W Y Kwong, C L M Hui, S K W Chan, E H M Lee, E Y H Chen
BACKGROUND: Better understanding of the complex interplay among key determinants of functional outcome is crucial to promoting recovery in psychotic disorders. However, this is understudied in the early course of illness. We aimed to examine the relationships among negative symptoms, neurocognition, general self-efficacy and global functioning in first-episode psychosis (FEP) patients using structural equation modeling (SEM). METHOD: Three hundred and twenty-one Chinese patients aged 26-55 years presenting with FEP to an early intervention program in Hong Kong were recruited...
November 21, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27863280/smoking-status-and-its-relationship-to-demographic-and-clinical-characteristics-in-first-episode-psychosis
#9
Michael Grossman, Christopher R Bowie, Martin Lepage, Ashok K Malla, Ridha Joober, Srividya N Iyer
Elevated rates of cigarette smoking are observed prior to the onset of psychosis and remain stable early in the illness. Cannabis use frequently co-occurs with cigarette smoking and is independently associated with distinct clinical outcomes. However, past research has not controlled for cannabis use in cigarette smokers with first episode psychosis (FEP), limiting conclusions on the unique relationship of cigarette smoking to the demographic and clinical profiles of these patients. The present study therefore aimed to: (1) Determine the prevalence and patterns of cigarette smoking and its co-use with cannabis in FEP, and (2) Examine the demographic, clinical, cognitive, and functional characteristics associated with cigarette smoking status, after adjusting for frequency of cannabis use...
October 27, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27863046/early-psychosis-intervention-outpatient-service-of-the-1st-psychiatric-university-clinic-in-athens-3-years-of-experience
#10
Constantinos Kollias, Lida-Alkisti Xenaki, Stefanos Dimitrakopoulos, Ioannis Kosteletos, Vassilis Kontaxakis, Nikos Stefanis, Charalampos Papageorgiou
To present the 3-year experience of the early intervention in psychosis (EIP) service implementation of the 1st Psychiatric University Clinic in Athens. An overview of: (1) the purpose of our service, (2) the referral network, (3) the selection criteria, (4) the diagnostic procedures, (5) the therapeutic interventions and (6) the research activities. The service was established in 2012 and developed gradually aiming to provide information, early detection, treatment and support to people aged 15 to 40 years with psychotic manifestations, who are either at increased risk of developing psychosis (at-risk mental state [ARMS]) or with first episode psychosis (FEP)...
November 9, 2016: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/27860369/factor-structure-of-therapist-fidelity-to-individual-resiliency-training-in-the-recovery-after-an-initial-schizophrenia-episode-early-treatment-program
#11
Julia Browne, Alexandra N Edwards, David L Penn, Piper S Meyer-Kalos, Jennifer D Gottlieb, Paul Julian, Kelsey Ludwig, Kim T Mueser, John M Kane
BACKGROUND: Evidence-based approaches and early intervention have improved the long-term prognosis of individuals with schizophrenia. However, little is known about the therapeutic processes involved in individual therapy in first-episode psychosis. A comprehensive psychosocial/psychiatric programme for this population, NAVIGATE, includes an individual therapy component, individual resiliency training (IRT). Fidelity of clinicians' adherence to the IRT protocol has been collected to ensure proper implementation of this manual-based intervention...
November 9, 2016: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/27845774/serum-metabolite-profile-associates-with-the-development-of-metabolic-co-morbidities-in-first-episode-psychosis
#12
T Suvitaival, O Mantere, T Kieseppä, I Mattila, P Pöhö, T Hyötyläinen, J Suvisaari, M Orešič
Psychotic patients are at high risk for developing obesity, metabolic syndrome and type 2 diabetes. These metabolic co-morbidities are hypothesized to be related to both treatment side effects as well as to metabolic changes occurring during the psychosis. Earlier metabolomics studies have shown that blood metabolite levels are predictive of insulin resistance and type 2 diabetes in the general population as well as sensitive to the effects of antipsychotics. In this study, we aimed to identify the metabolite profiles predicting future weight gain and other metabolic abnormalities in psychotic patients...
November 15, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27845318/-the-cellular-factors-of-innate-immunity-in-nonpsychotic-patients-at-high-risk-for-schizophrenia
#13
E F Vasil'eva, S G Kushner, M I Faktor, M A Omel'chenko, E D Bogdanova, L N Petrakova, O S Brusov
AIM: Changes in the parameters of innate immunity in patients with schizophrenia are observed already in the first episode. The study was performed to find out whether these changes take place prior to disease manifestation, and what role do they play in the pathogenesis of schizophrenia. MATERIAL AND METHODS: Thirty-five male nonpsychotic patients at high risk of psychosis, aged between 17 to 23 years, were examined. Phagocyte activity (PA) of neutrophils in the blood serum was evaluated by the number of active neutrophils, i...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27835719/adjunctive-taurine-in-first-episode-psychosis-a-phase-2-double-blind-randomized-placebo-controlled-study
#14
Colin P O'Donnell, Kelly A Allott, Brendan P Murphy, Hok Pan Yuen, Tina-Marie Proffitt, Alicia Papas, Jennifer Moral, Tee Pham, Michaela K O'Regan, Christina Phassouliotis, Raelene Simpson, Patrick D McGorry
OBJECTIVE: Taurine is an inhibitory neuromodulatory amino acid in the central nervous system that activates the GABA- and glycine-insensitive chloride channel and inhibits the N-methyl-d-aspartate receptor. It also functions as a neuroprotective agent and has a role in neural development and neurogenesis. The aim of this study was to determine the efficacy of adjunctive taurine in improving symptomatology and cognition among patients with a DSM-IV first-episode psychotic disorder. METHODS: 121 patients with first-episode psychosis, aged 18-25 years, attending early intervention services consented to participate in this randomized, double-blind, placebo-controlled trial conducted from January 2007 to May 2009...
November 8, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27834101/outcome-of-first-episode-acute-and-transient-psychotic-disorder-in-hong-kong-chinese-a-20-year-retrospective-follow-up-study
#15
Johannes Yin Kwong Poon, Chi Ming Leung
BACKGROUND: 'Acute and transient psychotic disorder' (ATPD) is a category in ICD-10 marked by psychosis with acute onset and early remission. It remains relatively under-researched, despite controversies over its nosological status in the current classification system. AIMS: (1) To assess the changes in diagnosis over time in patients initially diagnosed as ATPD. (2) To identify factors predicting changes in diagnosis, and compare the long-term outcomes of various patterns of diagnostic shift...
November 11, 2016: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/27833222/a-study-of-soft-neurological-signs-and-its-correlates-in-drug-naive-patients-with-first-episode-psychosis
#16
Vanishree Gunasekaran, V Mathan Kumar Venkatesh, T V Asokan
BACKGROUND: Soft neurological signs are minor, non localizing, objective abnormalities, thought to reflect damage in cortical and sub-cortical connections or connections within different cortical regions. Regional structural grey matter anomalies have already been observed and correlated with the presence of cognitive deficits and presence of soft neurological signs in schizophrenic patients. MATERIALS AND METHODS: Drug naive patients presenting with first episode of psychosis (FEP)were clinically evaluated for soft neurological signs using the Cambridge Neurological Inventory...
September 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27825609/cognitive-impairments-in-patients-with-first-episode-psychosis-the-relationship-between-neurophysiological-and-neuropsychological-assessments
#17
Isabel Morales-Muñoz, Rosa Jurado-Barba, Sara Fernández-Guinea, María José Álvarez-Alonso, Roberto Rodríguez-Jiménez, Miguel Angel Jiménez-Arriero, Gabriel Rubio
Cognitive deficits in schizophrenia have been widely reported. Neurophysiological and neuropsychological assessments have been conducted to study these impairments. Event-related potentials (ERPs) are relevant markers of cognitive deficits in schizophrenia, and reductions in specific ERP components have been found. The MATRICS Consensus Cognitive Battery (MCCB) was developed to obtain a consensus battery for the assessment of cognitive deficits in schizophrenia. Here, we aimed to study modulations of several ERP components in first episode psychosis (FEP)...
November 4, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27804260/cortisol-and-acth-levels-in-drug-naive-adolescents-with-first-episode-early-onset-schizophrenia
#18
Şeref Şimşek, Salih Gençoğlan, Tuğba Yüksel, Hüseyin Aktaş
The aim of this study was to investigate serum levels of cortisol and adrenocorticotropic hormone in adolescents with first-episode early onset schizophrenia. A total of 23 adolescent patients, who did not receive prior therapy and who were diagnosed with psychosis according to DSM-IV, were included. Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version, Positive and Negative Symptom Scale, and Clinical Global Impression Scale were conducted with the participants. No significant differences were found between the patients and the control subjects in serum cortisol and adrenocorticotropic hormone levels (P > ...
November 2, 2016: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/27804008/detecting-incipient-schizophrenia-a-validation-of-the-azima-battery-in-first-episode-psychosis
#19
Hiba Zafran, Barbara Mazer, Beverlea Tallant, Gevorg Chilingaryan, Isabelle Gelinas
Early psychosis intervention aims to accurately detect adolescents and young adults at risk for major mental disorders, particularly schizophrenia, yet early biomedical diagnostic accuracy remains poor. However, phenomenological approaches focusing on eliciting and understanding the subjective experience of help-seeking youth better detect incipient schizophrenia. The Azima Battery is an occupational therapy projective assessment that uses expressive media in a standard setup, in order to phenomenologically elicit and describe the activity performance and narratives of individuals at risk of, or on, the psychotic-spectrum...
November 2, 2016: Psychiatric Quarterly
https://www.readbyqxmd.com/read/27802977/should-psychiatrists-be-more-cautious-about-the-long-term-prophylactic-use-of-antipsychotics
#20
Robin M Murray, Diego Quattrone, Sridhar Natesan, Jim van Os, Merete Nordentoft, Oliver Howes, Marta Di Forti, David Taylor
Patients who recover from an acute episode of psychosis are frequently prescribed prophylactic antipsychotics for many years, especially if they are diagnosed as having schizophrenia. However, there is a dearth of evidence concerning the long-term effectiveness of this practice, and growing concern over the cumulative effects of antipsychotics on physical health and brain structure. Although controversy remains concerning some of the data, the wise psychiatrist should regularly review the benefit to each patient of continuing prophylactic antipsychotics against the risk of side-effects and loss of effectiveness through the development of supersensitivity of the dopamine D2 receptor...
November 2016: British Journal of Psychiatry: the Journal of Mental Science
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