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https://www.readbyqxmd.com/read/29684395/streptozotocin-toxicity-in-vitro-depends-on-maturity-of-neurons
#1
Nickolay K Isaev, Elisaveta E Genrikhs, Dmitriy N Voronkov, Marina R Kapkaeva, Elena V Stelmashook
Streptozotocin (STZ) is a glucosamine-nitrosourea compound that is particularly toxic to the insulin-producing beta-cells of the pancreas in mammals; it is used for experimental simulation of sporadic Alzheimer's disease by means of intracerebroventricular administration in vivo. Here we show that the application of 3-4 mM STZ to primary culture for 48 h induces neuronal death in immature (2-3 days in vitro) cultures of rat cerebellar granule cells. Mature cultures (7-8 days in vitro) were poorly sensitive to this toxic treatment...
April 20, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29684363/immunolabeling-of-cleared-human-pancreata-provides-insights-into-three-dimensional-pancreatic-anatomy-and-pathology
#2
Michaël Noë, Neda Rezaee, Kaushal Asrani, Michael Skaro, Vincent P Groot, Pei-Hsun Wu, Matthew T Olson, Seung-Mo Hong, Sung Joo Kim, Matthew J Weiss, Christopher L Wolfgang, Martin A Makary, Jin He, John L Cameron, Denis Wirtz, Nicholas J Roberts, G Johan A Offerhaus, Lodewijk A A Brosens, Laura D Wood, Ralph H Hruban
Visualizing pathologies in three dimensions (3D) can provide unique insights into the biology of human diseases. A rapid and easy-to-implement dibenzyl ether-based technique was used to clear thick sections of surgically resected human pancreatic parenchyma. Protocols were applicable to both fresh and formalin-fixed paraffin-embedded tissue. The penetration of antibodies into dense pancreatic parenchyma was optimized using both gradually increasing antibody concentrations and centrifugal flow. Immunolabeling with antibodies against CK19 was visualized using both light sheet and confocal laser scanning microscopy...
April 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29683978/antimicrobial-peptide-human-neutrophil-peptide-1-as-a-potential-link-between-chronic-inflammation-and-ductal-adenocarcinoma-of-the-pancreas
#3
Thomas Pausch, Sarah Adolph, Klaus Felix, Andrea S Bauer, Frank Bergmann, Jens Werner, Werner Hartwig
OBJECTIVES: Defensins are antimicrobial peptides playing a role in innate immunity, in epithelial cell regeneration, and in carcinogenesis of inflammation-triggered malignancies. We analyzed this role in pancreatic ductal adenocarcinoma (PDAC) in the context of its association with chronic pancreatitis (CP). METHODS: Human tissue of healthy pancreas, CP, and PDAC was screened for defensins by immunohistochemistry. Defensin α 1 (human neutrophil peptide 1 [HNP-1]) expression was validated using mass spectrometry and microarray analysis...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683975/prediction-of-insulin-secretion-ability-with-microcirculation-evaluated-by-contrast-enhanced-ultrasonography-in-pancreas-transplantation
#4
Naohiro Aida, Takashi Kenmochi, Taihei Ito, Toru Nishikawa, Izumi Hiratsuka, Megumi Shibata, Atsushi Suzuki, Midori Hasegawa, Akihiro Kawai, Mamoru Kusaka, Kiyotaka Hoshinaga, Hisahiro Matsubara
OBJECTIVES: Contrast-enhanced ultrasonography can evaluate microcirculation. Thus, we used contrast-enhanced ultrasonography in evaluating pancreas graft perfusion and examined the relationship between graft circulation and function. METHODS: Contrast-enhanced ultrasonography was performed in 17 cases within 24 hours and at 1, 3, 5, 7, 14, 21, and 28 days after transplantation (Tx). The time between the time to peak intensity in the parenchyma and that in the vein was defined as delta-Tp(P-V)...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683974/pancreatic-neuroendocrine-tumors-and-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-a-systematic-review
#5
Alba Manuel-Vazquez, José Manuel Ramia, Raquel Latorre-Fragua, Ainhoa Valle-Rubio, Vladimir Arteaga-Peralta, Carmen Ramiro-Pérez, Roberto de la Plaza-Llamas
OBJECTIVES: This study aimed to identify factors that explain the association of intraductal papillary mucinous neoplasms-pancreatic neuroendocrine tumors (IPMNs-PNETs), radiological characteristics, and factors that might guide therapy. METHODS: We performed a systematic review of the literature to search for articles on concurrent IPMN-PNET, mixed endocrine-exocrine pancreatic tumors, and/or PNET with an intraductal growth pattern. RESULTS: A review of the literature suggests that there is some confusion about association of IPMNs-PNETs...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683972/bladder-versus-enteric-drainage-of-exocrine-secretions-in-pancreas-transplantation-a-retrospective-analysis-of-the-united-network-for-organ-sharing-database
#6
Eric J Siskind, Leo I Amodu, Sonia Pinto, Meredith Akerman, Johann Jonsson, Ernesto P Molmenti, Jorge Ortiz
OBJECTIVES: The method for drainage of exocrine secretions in pancreas transplantation remains a matter of debate. Different methods have evolved over time. Most data on these methods are from single-center studies with small sample sizes. Larger studies have yielded conflicting results. METHODS: Data from the United Network for Organ Sharing database on all adult subjects who received pancreas and kidney-pancreas transplants between 1996 and 2012 were analyzed (n = 19,934)...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683968/functional-correlation-between-the-pancreas-and-the-small-intestine-in-humans-the-first-evaluation-using-a-newly-developed-enteroscopy
#7
Daijuro Hayashi, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Takamichi Kuwahara, Manabu Kawai, Takeshi Yamamura, Kazuhiro Furukawa, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Masatoshi Ishigami, Senju Hashimoto, Hidemi Goto
OBJECTIVES: The aim of this study is to evaluate a functional correlation between the pancreas and the small intestine and the association of this relationship with nutritional status, using magnifying enteroscopy. METHODS: The subjects were adults aged 20 years or older who underwent upper gastrointestinal endoscopy. An endoscope was inserted into the jejunum, and 10% glucose was sprayed under magnifying observation to evaluate changes in blood flow in the villous capillary network...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683470/in-vivo-toxicity-of-the-ribosome-inactivating-lectin-ebulin-f-in-elderly-mice
#8
Manuel Garrosa, Pilar Jiménez, Damián Córdoba-Díaz, Verónica García-Recio, Sara Gayoso, María Ángeles Rojo, Manuel J Gayoso, Tomás Girbés
Ebulin f is a ribosome-inactivating protein (RIP) present in green fruits of the dwarf elder (Sambucus ebulus L). Since dwarf elder fruits are used for food and as a medicine, we assessed the study of toxicological effects and safety of ebulin f in elderly mice, comparing these results with those reported in young animals and with other RIPs. Female Swiss mice aged 6 and 12 months of age were intraperitoneally injected with a single dose from 1.4 to 4.5 mg/kg ebulin f. Heart, stomach, intestines, lung, kidney, liver, spleen, pancreas, adrenal gland, uterus, ovary and brain were studied...
April 23, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29683218/-outcome-of-patients-with-hemodialysis-or-peritoneal-dialysis-undergoing-simultaneous-pancreas-kidney-transplantation-comparative-study
#9
Alberto Marcacuzco, Carlos Jiménez-Romero, Alejandro Manrique, Jorge Calvo, Félix Cambra, Óscar Caso, Álvaro García-Sesma, Anisa Nutu, Iago Justo
BACKGROUND: Controversy remains with regard to the higher risk of intraabdominal infections and lower patient and graft survival when peritoneal dialysis (PD) rather than hemodialysis (HD) is used in simultaneous pancreas-kidney transplantation (SPKT). METHODS: From March 1995 to December 2015 we performed 165 SPKTs. Prior to transplant, patients received hemodialysis (Group HD; n=98) or peritoneal dialysis (Group PD; n=67). A comparison was performed to analyze posttransplant complications and patient, pancreas and kidney graft survivals...
April 23, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29682693/costs-of-cancer-care-for-elderly-patients-with-neuroendocrine-tumors
#10
Chan Shen, Arvind Dasari, Dian Gu, Yiyi Chu, Shouhao Zhou, Ying Xu, Daniel Halperin, Shuangshuang Fu, James C Yao, Ya-Chen Tina Shih
BACKGROUND: The incidence and prevalence of neuroendocrine tumors (NETs) have been steadily rising. NETs can arise in various parts of the body and have distinct pathogenesis, clinical manifestations, treatment, and survival compared to other neoplasms. The magnitude of the economic burden of NETs is largely unknown. This study aimed to estimate the cost of illness for NETs among elderly patients based on a large amount of observational data. METHODS: We estimated the direct medical costs by phase of care using the Surveillance, Epidemiology, and End Results-Medicare data, including claims from January 1, 2002 through to December 31, 2012...
April 23, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29682389/blunt-pancreatic-injury-in-major-trauma-decision-making-between-nonoperative-and-operative-treatment
#11
Christopher Ull, Sebastian Bensch, Thomas Armin Schildhauer, Justyna Swol
Blunt trauma injuries to the pancreas are rare but are associated with significant overall mortality and a high complication rate. Motor vehicle collisions are the leading cause of blunt pancreatic trauma, followed by falls, and sports injuries. We discuss the decision-making process used during the clinical courses of 3 patients with life-threatening blunt pancreatic injuries caused by traumatic falls. We also discuss the utility of the American Association for the Surgery of Trauma Organ Injury Scale (AAST-OIS), which provides a system for grading pancreatic trauma...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29681814/non-gestational-choriocarcinoma-with-widespread-metastases-presenting-with-type-1-respiratory-failure-in-a-39-year-old-female-case-report-and-review-of-the-literature
#12
Louisa Stockton, Elizabeth Green, Baljeet Kaur, Emma De Winton
Introduction: Non-gestational choriocarcinoma (NGCC) is an extremely rare cancer. We report a case presenting in extremis. Case Report: A 39-year-old woman presented with type 1 respiratory failure with a 1-month history of breathlessness. Computed tomography (CT) revealed widespread metastatic disease involving the lungs, liver, pancreas, and breast. Serum β-human chorionic gonadotropin was markedly raised. Over 72 h, she deteriorated and was started on high-flow nasal cannula to facilitate discussions and for comfort...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29681634/urological-manifestations-of-the-disease-related-to-immunoglobulin-g4
#13
Luis Daniel Carrillo-Córdova, Carlos Alberto Carrillo-Córdova, Johnatan Vitar-Sandoval, Jorge Jaspersen-Álvarez, Elba Luz Villena-López, Raúl Carrillo-Esper
Immunoglobulin G4 related disease (IgG4-RD) is a fibro-inflammatory disease of unknown etiology, characterized by lesions in the form of tumors, elevated serum IgG4 levels, plasma cells with significant IgG4 infiltration, accompanied by phlebitis obliterans and fibrosis. This disease usually has multiorgan disease, including pancreas, biliary tract, salivary glands, peri orbital tissues, kidneys, lungs, lymph nodes and retro peritoneum. IgG4-RD mainly affects men with a predominance of age by young adults until old age...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29681580/cancer-incidence-and-mortality-patterns-in-luwan-district-of-shanghai-during-2002-2011
#14
Jue Wang, Shuna Gao, Yejing Wang, Jianjun Zhou, Jing Lin, Ling Wang, Yan Du
Cancer has become the leading cause of death and a major burden to public health in China. The current study analyzed the composition, incidence, mortality, and temporal trends for some major cancer types among permanent residents in Luwan district of Shanghai from 2002 to 2011, so as to provide data for cancer research. Data were collected from the database of cancer registration and management system in Shanghai. Number of new cases, number of deaths, incidence, and mortality of each cancer type were calculated...
April 22, 2018: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29681182/fetal-pancreatic-langerhans-islets-size-in-pregnancies-with-metabolic-disorders
#15
Laura Avagliano, Margaret Mascherpa, Valentina Massa, Patrizia Doi, Gaetano P Bulfamante
Metabolic disorders are a pandemic and increasing health problem. Women of childbearing age may also be affected, thus an abnormal metabolism may interfere with pregnancy short and long term outcomes, harming both mother and child. In the context of an abnormal maternal and intrauterine metabolic milieu the development of fetal organs, including pancreas, may be affected. The aim of the present study is to investigate the effects of pregnancy metabolic disorders on the morphology of pancreatic Langerhans islets in human late-third trimester stillborn fetuses...
April 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29681172/analyzing-the-potential-of-advanced-insulin-dosing-strategies-in-patients-with-type-2-diabetes-results-from-a-hybrid-in-silico-study
#16
Florian Reiterer, Matthias Reiter, Luigi Del Re, Merete Bechmann Christensen, Kirsten Nørgaard
BACKGROUND: The ongoing improvement of continuous glucose monitoring (CGM) sensors and of insulin pumps are paving the way for a fast implementation of artificial pancreas (AP) for type 1 diabetes (T1D) patients. The case for type 2 diabetes (T2D) patients is less obvious since usually some residual beta cell function allows for simpler therapy approaches, and even multiple daily injections (MDI) therapy is not very widespread. However, the number of insulin dependent T2D patients is vastly increasing and therefore a need for understanding chances and challenges of an automated insulin therapy arises...
April 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29681134/an-audit-of-pregnancy-outcomes-in-solid-organ-transplant-recipients-at-a-metropolitan-hospital
#17
Yunjing E Fang, Roshini Nayyar, Hayley Diplock
BACKGROUND: Pregnancies in patients with solid organ transplants have higher rates of complications and caesarean sections (CS). AIM: To perform an audit of the pregnancy outcomes in transplant recipients, to determine the rate of CS in our cohort, the appropriate skin incision for CS in these patients and to formulate recommendations for preoperative planning. MATERIALS AND METHODS: This is a retrospective cohort study. All patients who had a solid organ transplant were identified from the obstetrics database...
April 22, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29680252/demonstration-of-safety-and-feasibility-of-hydrogel-marking-of-the-pancreas-duodenum-interface-for-image-guided-radiation-therapy-igrt-in-a-porcine-model-implications-in-igrt-for-pancreatic-cancer-patients
#18
Avani D Rao, Eun Ji Shin, Sarah E Beck, Caroline Garrett, Seong-Hun Kim, Nam Ju Lee, Eleni Liapi, John Wong, Joseph Herman, Amol Narang, Kai Ding
PURPOSE: To test the feasibility and safety of injecting a high-contrast hydrogel marker at the head of the pancreas (HOP) and duodenum interface and assesses the marker visibility on cone beam computed tomography (CBCT) to localize this important boundary during image guided radiation therapy in a porcine model. METHODS AND MATERIALS: This was a 2-stage study. The feasibility/visibility stage evaluated the ability to place the hydrogel using endoscopic ultrasound guidance on 8 swine (4 euthanized at post-injection day 8, 4 euthanized at post-injection day 22) and assessed the quality of visibility of the marked location on CBCT in the longer-surviving group...
March 2, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29679893/identification-of-homocysteine-suppressive-mitochondrial-etc-complex-genes-and-tissue-expression-profile-novel-hypothesis-establishment
#19
Ramon Cueto, Lixiao Zhang, Hui Min Shan, Xiao Huang, Xinyuan Li, Ya-Feng Li, Jahaira Lopez, William Y Yang, Muriel Lavallee, Catherine Yu, Yong Ji, Xiaofeng Yang, Hong Wang
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease (CVD) which has been implicated in matochondrial (Mt) function impairment. In this study, we characterized Hcy metabolism in mouse tissues by using LC-ESI-MS/MS analysis, established tissue expression profiles for 84 nuclear-encoded Mt electron transport chain complex (nMt-ETC-Com) genes in 20 human and 19 mouse tissues by database mining, and modeled the effect of HHcy on Mt-ETC function. Hcy levels were high in mouse kidney/lung/spleen/liver (24-14 nmol/g tissue) but low in brain/heart (~5 nmol/g)...
April 4, 2018: Redox Biology
https://www.readbyqxmd.com/read/29678923/eje-prize-2018-a-gut-feeling-about-glucagon
#20
Filip Krag Knop
Hyperglucagonaemia (in the fasting as well as in the postprandial state) is considered a core pathophysiological component of diabetes and to contribute substantially to the hyperglycaemic state of diabetes. Hyperglucagonaemia is usually viewed upon as a consequence of pancreatic alpha cell insensitivity to the glucagon-suppressive effects of glucose and insulin. Since we observed that the well-known hyperglucagonaemic response to oral glucose in patients with type 2 diabetes is exchanged by normal suppression of plasma glucagon levels following isoglycaemic intravenous glucose administration in these patients, we have been focusing on the gut and gut-derived factors as potential mediators of diabetic hyperglucagonaemia...
April 20, 2018: European Journal of Endocrinology
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