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https://www.readbyqxmd.com/read/29656621/effect-of-myoarchitectonic-spinolaminoplasty-on-concurrent-hypertension-in-patients-with-cervical-spondylotic-myelopathy
#1
Kazushige Itoki, Ryu Kurokawa, Tetsuro Shingo, Phyo Kim
OBJECTIVE: When treating patients with cervical spondylotic myelopathy (CSM), we often note amelioration in concomitant hypertension after surgery. To assess the effects of surgery and the mechanisms thereof, blood pressure (BP) and parasympathetic nervous activity were monitored prospectively in CSM patients undergoing surgery. METHODS: Sixty-eight consecutive CSM patients who underwent surgery with myoarchitectonic spinolaminoplasty were enrolled. BP and electrocardiography were recorded preoperatively and at 1, 3, and 6 months postoperatively...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656594/immune-imbalance-of-global-gene-expression-and-cytokine-chemokine-and-selectin-levels-in-the-brains-of-offspring-with-social-deficits-via-maternal-immune-activation
#2
Pei-Tan Hsueh, Hsi-Hsun Lin, Hsuan-Han Wang, Chiu-Lin Liu, Wei-Fen Ni, Jong-Kang Liu, Hsin-Hou Chang, Der-Shan Sun, Yao-Shen Chen, Ya-Lei Chen
The murine maternal immune activation (MIA) offspring model enables longitudinal studies to explore aberrant social behaviors similar to those observed in humans. High levels of cytokines, chemokines and cell adhesion molecules (CAM) have been found in the plasma and/or brains of psychiatric patients. We hypothesized that up-regulation of the systemic or brain immune response has an augmenting effect by potentially increasing the interplay between the neuronal and immune systems during the growth of the MIA offspring...
April 15, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29656582/hyperactive-cyclic-motor-activity-in-the-distal-colon-after-colonic-surgery-as-defined-by-high-resolution-colonic-manometry
#3
R Vather, G O'Grady, A Y Lin, P Du, C I Wells, D Rowbotham, J Arkwright, L K Cheng, P G Dinning, I P Bissett
BACKGROUND: Recovery after colonic surgery is invariably delayed by disturbed gut motility. It is commonly assumed that colonic motility becomes quiescent after surgery, but this hypothesis has not been evaluated rigorously. This study quantified colonic motility through the early postoperative period using high-resolution colonic manometry. METHODS: Fibre-optic colonic manometry was performed continuously before, during and after surgery in the left colon and rectum of patients undergoing right hemicolectomy, and in healthy controls...
April 14, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29656472/in-vitro-and-in-vivo-characterization-of-an-interleukin-15-antagonist-peptide-by-metabolic-stability-99m-tc-labeling-and-biological-activity-assays
#4
Yunier Rodríguez-Álvarez, Ania Cabrales-Rico, Alejandro Perera-Pintado, Anais Prats-Capote, Hilda E Garay-Pérez, Osvaldo Reyes-Acosta, Erik Pérez-García, Araceli Chico-Capote, Alicia Santos-Savio
Interleukin (IL)-15 is an inflammatory cytokine that constitutes a validated therapeutic target in some immunopathologies, including rheumatoid arthritis (RA). Previously, we identified an IL-15 antagonist peptide named [K6T]P8, with potential therapeutic application in RA. In the current work, the metabolic stability of this peptide in synovial fluids from RA patients was studied. Moreover, [K6T]P8 peptide was labeled with 99m Tc to investigate its stability in human plasma and its biodistribution pattern in healthy rats...
April 15, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29656444/predicting-therapeutic-response-to-fingolimod-treatment-in-multiple-sclerosis-patients
#5
Bibiana Quirant-Sánchez, José V Hervás-García, Aina Teniente-Serra, Luis Brieva, Ester Moral-Torres, Antonio Cano, Elvira Munteis, María J Mansilla, Silvia Presas-Rodriguez, Juan Navarro-Barriuso, Cristina Ramo-Tello, Eva M Martínez-Cáceres
AIMS: Fingolimod, an orally active immunomodulatory drug for relapsing-remitting multiple sclerosis (RRMS), sequesters T cells in lymph nodes through functional antagonism of the sphingosine-1-phosphate receptor, reducing the number of potential autoreactive cells that migrate to the central nervous system. However, not all RRMS patients respond to this therapy. Our aim was to test the hypothesis that by immune-monitoring RRMS patient's leukocyte subpopulations it is possible to find biomarkers associated with clinical response to fingolimod...
April 15, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29656375/does-erythrocyte-sedimentation-rate-reflect-and-discriminate-flare-from-infection-in-systemic-lupus-erythematosus-correlation-with-clinical-and-laboratory-parameters-of-disease-activity
#6
Valentin Sebastian Schäfer, Katharina Weiß, Andreas Krause, Wolfgang Andreas Schmidt
To examine disease activity parameters in patients with systemic lupus erythematosus (SLE) experiencing flare, infection, both, or neither condition, focusing on erythrocyte sedimentation rate (ESR). This study is a retrospective analysis of 371 consecutive inpatient SLE cases from 2006 to 2015. Cases were classified as flare (n = 147), infection (n = 48), both (n = 23), or neither (n = 135). ESR levels were correlated to C-reactive protein (CRP), ferritin, anti-dsDNA antibodies, complement C3 reduction, serositis, and erythrocyturia with proteinuria (Pearson's correlation)...
April 14, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29656373/evaluation-of-disease-activity-in-patients-with-rheumatoid-arthritis-treated-with-tofacitinib-by-rapid3-post-hoc-analyses-from-two-phase-3-trials
#7
Vibeke Strand, Eun Bong Lee, Yusuf Yazici, Ara Dikranian, Bethanie Wilkinson, Liza Takiya, Chuanbo Zang, Eustratios Bananis, Martin J Bergman
Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis. We evaluated the relationship between disease activity, according to Routine Assessment of Patient Index Data 3 (RAPID3) after 6-month treatment with tofacitinib, and long-term outcomes at 24 months. This was a post hoc analysis of two 24-month, phase 3, randomized controlled trials in methotrexate (MTX)-naïve (ORAL Start [NCT01039688]) or MTX-inadequate responder patients (ORAL Scan [NCT00847613]) receiving tofacitinib 5 or 10 mg twice daily (BID) as monotherapy or with background MTX...
April 14, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29656372/serum-calprotectin-may-reflect-inflammatory-activity-in-patients-with-active-rheumatoid-arthritis-despite-normal-to-low-c-reactive-protein
#8
Jana Hurnakova, Hana Hulejova, Jakub Zavada, Martin Komarc, Lucie Andres Cerezo, Herman Mann, Jiri Vencovsky, Karel Pavelka, Ladislav Senolt
Approximately half of patients with rheumatoid arthritis (RA) have normal C-reactive protein (CRP) levels. Calprotectin is a promising and likely more specific biomarker of disease activity than conventionally used acute phase reactants. We aimed to analyse the levels of serum calprotectin in RA patients with clinically active disease and with normal/low CRP. A total of 160 RA patients underwent clinical examination (DAS28-ESR and CDAI). The levels of calprotectin were analysed in patients with moderate to high disease activity with normal/low CRP levels and in 32 healthy subjects...
April 14, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29656364/characteristic-appearances-of-fundus-autofluorescence-in-treatment-naive-and-active-polypoidal-choroidal-vasculopathy-a-retrospective-study-of-170-patients
#9
Xinyu Zhao, Song Xia, Youxin Chen
PURPOSE: To investigate the characteristic appearances of fundus autofluorescence (FAF) in patients with treatment-naive and active polypoidal choroidal vasculopathy (PCV). METHOD: Cases with the diagnosis of treatment-naive and active PCV from November 2012 to May 2017 at Peking Union Medical College Hospital were retrospectively reviewed. All patients underwent comprehensive ophthalmologic examination. Autofluorescence (AF) findings were described at the retinal sites of the corresponding lesions identified and diagnosed using indocyanine green angiography and spectral-domain optical coherence tomography...
April 14, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29656319/nlrp3-inflammasome-involves-in-the-acute-exacerbation-of-patients-with-chronic-obstructive-pulmonary-disease
#10
Huaying Wang, Chun'er Lv, Shi Wang, Huajuan Ying, Yuesong Weng, Wanjun Yu
The NLR pyrin domain-containing protein 3 (NLRP3) inflammasome, a multi-protein complex, produces the pro-inflammatory cytokines interleukin (IL)-1β and IL-18, which may contribute to the development of airway inflammation in chronic obstructive pulmonary disease (COPD). The aim of this study was to explore the correlation between circulating and local airway NLRP3 inflammasome activation with acute exacerbation of COPD (AECOPD). mRNA levels of NLRP3, Caspase (Casp)-1, apoptosis-associated speck-like protein containing CARD (ASC), IL-18, and IL-1β in peripheral blood mononuclear cells (PBMCs) and bronchial tissues were determined by real-time PCR in 32 smokers, 65 patients with AECOPD, 50 COPD patients in recovery stage, and 30 COPD patients in stable stage...
April 14, 2018: Inflammation
https://www.readbyqxmd.com/read/29656306/oral-and-sublingual-immunotherapy-for-treatment-of-ige-mediated-food-allergy
#11
REVIEW
Amy M Scurlock
Development of active therapies for IgE-mediated food allergy is a critical action step toward alleviating the adverse medical, psychosocial, and economic burdens on affected patients and families. Significant progress has been observed specifically in the application of single-allergen oral and sublingual immunotherapy for treatment of IgE-mediated food allergy, with emphasis on milk, egg, and peanut as the primary allergens. Oral immunotherapy (OIT) has demonstrated efficacy in promoting immunomodulatory effects that lead to the clinical outcome of desensitization, defined as reduced reactivity while on active OIT, in the majority of treated individuals; however, achievement of sustained unresponsiveness following cessation of therapy has been observed in a smaller subset of treated subjects...
April 14, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29656269/task-positive-and-task-negative-networks-in-major-depressive-disorder-a-combined-fmri-and-eeg-study
#12
Gennady G Knyazev, Alexander N Savostyanov, Andrey V Bocharov, Ivan V Brak, Evgeny A Osipov, Elena A Filimonova, Alexander E Saprigyn, Lyubomir I Aftanas
BACKGROUND: The study of intrinsic connectivity networks, i.e., sets of brain regions that show a high degree of interconnectedness even in the absence of a task, showed that major depressive disorder (MDD) patients demonstrate an increased connectivity within the default mode network (DMN), which is active in a resting state and is implicated in self-referential processing, and a decreased connectivity in task-positive networks (TPNs), which increase their activity in attention tasks...
April 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29656259/increased-coherence-based-regional-homogeneity-in-resting-state-patients-with-first-episode-drug-naive-somatization-disorder
#13
Yangpan Ou, Feng Liu, Jindong Chen, Pan Pan, Renrong Wu, Qinji Su, Zhikun Zhang, Jingping Zhao, Wenbin Guo
BACKGROUND: Abnormal neural activity has been observed in patients with somatization disorder (SD), especially in brain regions of the default-mode network (DMN). In this study, a coherence-based regional homogeneity (Cohe-ReHo) approach was used to detect abnormal regional synchronization in patients with SD, which might be used to differentiate the patients from the controls. METHODS: We recruited 25 patients with SD and 28 healthy controls. The imaging data of the participants were analyzed using the Cohe-ReHo approach...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29656212/myeloid-related-proteins-are-up-regulated-in-autoimmune-thyroid-diseases-and-activate-toll-like-receptor-4-and-pro-inflammatory-cytokines-in-vitro
#14
Shiqiao Peng, Xuren Sun, Xinyi Wang, Haoyu Wang, Zhongyan Shan, Weiping Teng, Chenyan Li
PURPOSE: Myeloid-related protein (MRP) family plays an important role in the promotion of cell proliferation and the production of inflammatory cytokines. We investigated the expression of MRP6, MRP8 and MRP14 in thyroid tissues, serum, and peripheral blood monocular cells (PBMCs) in patients with autoimmune thyroid diseases (AITD). METHOD: The expression of MRP6, MRP8, and MRP14 was investigated using immunohistochemical staining and quantitative real-time polymerase chain reaction in the thyroid glands of 7 patients with Graves' disease (GD), 8 with Hashimoto's thyroiditis (HT), and 7 healthy controls (HC)...
April 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29656185/exogenous-serp1-attenuates-restenosis-by-restoring-glp-1-receptor-activity-in-diabetic-rats-following-vascular-injury
#15
Lishuai Feng, Jianbo Wang, Xu Ma
The activity of glucagon-like peptide 1 (GLP-1R) is essential for preventing restenosis following vascular injury; however, the mechanism of dysfunctional GLP-1R glycosylation and ways to enhance the activity of GLP-1R on vascular surfaces in diabetic patients are poorly understood. In the present study, we investigated the N-glycosylation level and role of stress-associated endoplasmic reticulum protein 1 (SERP1) in preventing restenosis following carotid injury in diabetic rats. Our results showed that N-glycosylation levels in both rat aortic endothelial cells (RAOECs) and rat vascular smooth muscle cells (VSMCs) decreased gradually following glucose treatment in a concentration dependant manner...
April 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29656167/extracellular-vesicles-exposing-tissue-factor-for-the-prediction-of-venous-thromboembolism-in-patients-with-cancer-a-prospective-cohort-study
#16
Nick van Es, Yohei Hisada, Marcello Di Nisio, Gabriela Cesarman, Ankie Kleinjan, Isabelle Mahé, Hans-Martin Otten, Pieter W Kamphuisen, René J Berckmans, Harry R Büller, Nigel Mackman, Rienk Nieuwland
INTRODUCTION: The procoagulant activity of extracellular vesicles (EV) exposing tissue factor (TF) is a promising biomarker for venous thromboembolism (VTE) in cancer patients. We evaluated an in-house EV-TF activity assay (the fibrin generation test) for the prediction of cancer-associated VTE. We also compared the results with the fibrin generation tests to an EV-TF-dependent factor Xa generation assay in samples from pancreatic cancer patients. MATERIALS AND METHODS: Data collected in a multinational, prospective cohort study were used...
April 10, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29656147/liver-fibrosis-direct-antifibrotic-agents-and-targeted-therapies
#17
REVIEW
Detlef Schuppan, Muhammad Ashfaq-Khan, Ai Ting Yang, Yong Ook Kim
Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of patients with chronic liver disease. Their prevention or reversal have become major endpoints in clinical trials with novel liver specific drugs. Remarkable progress has been made with therapies that efficiently address the cause of the underlying liver disease, as in chronic hepatitis B and C. Highly effective antiviral therapy can prevent progression or even induce reversal in the majority of patients, but such treatment remains elusive for the majority of liver patients with advanced alcoholic or nonalcoholic steatohepatitis, genetic or autoimmune liver diseases...
April 12, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29656120/systemic-inflammatory-response-syndromes-in-the-era-of-interventional-cardiology
#18
REVIEW
Riccardo Gorla, Raimund Erbel, Kim A Eagle, Eduardo Bossone
Systemic inflammatory response syndrome (SIRS), initially reported after cardiovascular surgery, has been described after various interventional cardiology procedures, including endovascular/thoracic aortic repair (EVAR/TEVAR), implantation of heart rhythm devices, percutaneous coronary intervention (PCI), electrophysiology procedures (EP), and transcatheter aortic valve implantation (TAVI). In these settings, a comprehensive understanding of the triggers, pathogenesis as well as a common diagnostic/therapeutic algorithm is lacking and will be discussed in this review...
April 12, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29656116/chromogranin-a-and-its-derived-peptides-and-their-pharmacological-effects-during-intestinal-inflammation
#19
REVIEW
Nour Eissa, Hayam Hussein, Geoffrey N Hendy, Charles N Bernstein, Jean-Eric Ghia
The gastrointestinal tract is the largest endocrine organ that produces a broad range of active peptides. Mucosal changes during inflammation alter the distribution and products of enteroendocrine cells (EECs) that play a role in immune activation and regulation of gut homeostasis by mediating communication between the nervous, endocrine and immune systems. Patients with inflammatory bowel disease (IBD) typically have altered expression of chromogranin (CHG)-A (CHGA), a major soluble protein secreted by EECs that functions as a pro-hormone...
April 12, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29656099/hypsarrhythmia-in-epileptic-spasms-synchrony-in-chaos
#20
Vera Nenadovic, Robyn Whitney, Jason Boulet, Miguel A Cortez
PURPOSE: Hypsarrhythmia is an electroencephalographic pattern associated with epileptic spasms and West syndrome. West syndrome is a devastating epileptic encephalopathy, originating in infancy. Hypsarrhythmia has been deemed to be the interictal brain activity, while the electrodecremental event associated with the spasms is denoted as the ictal event. Though characterized as chaotic, asynchronous and disorganized based on visual inspection of the EEG, little is known of the dynamics of hypsarrhythmia and how it impacts the developmental arrest of these infants...
March 30, 2018: Seizure: the Journal of the British Epilepsy Association
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