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https://www.readbyqxmd.com/read/28631114/derivatization-of-dextran-for-multiply-charged-ion-formation-and-electrospray-ionization-time-of-flight-mass-spectrometric-analysis
#1
Jesus B Tapia, Hailey A J Hibbard, Melissa M Reynolds
We present the use of a simple, one-pot derivatization to allow the polysaccharide dextran to carry multiple positive charges, shifting its molecular weight distribution to a lower m/z range. We performed this derivatization because molecular weight measurements of polysaccharides by mass spectrometry are challenging because of their lack of readily ionizable groups. The absence of ionizable groups limits proton abstraction and suppresses proton adduction during the ionization process, producing mass spectra with predominantly singly charged metal adduct ions, thereby limiting the detection of large polysaccharides...
June 19, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28603771/magnitude-precision-and-realism-of-depth-perception-in-stereoscopic-vision
#2
Paul B Hibbard, Alice E Haines, Rebecca L Hornsey
Our perception of depth is substantially enhanced by the fact that we have binocular vision. This provides us with more precise and accurate estimates of depth and an improved qualitative appreciation of the three-dimensional (3D) shapes and positions of objects. We assessed the link between these quantitative and qualitative aspects of 3D vision. Specifically, we wished to determine whether the realism of apparent depth from binocular cues is associated with the magnitude or precision of perceived depth and the degree of binocular fusion...
2017: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/28520900/accelerating-high-dimensional-clustering-with-lossless-data-reduction
#3
Bahjat F Qaqish, Jonathon J O'Brien, Jonathan C Hibbard, Katie J Clowers
Motivation: For cluster analysis, high dimensional data is associated with instability, decreased classification accuracy and high computational burden. The latter challenge can be eliminated as a serious concern. For applications where dimension reduction techniques are not implemented, we propose a temporary transformation which accelerates computations with no loss of information. The algorithm can be applied for any statistical procedure depending only on Euclidean distances and can be implemented sequentially to enable analyses of data that would otherwise exceed memory limitations...
May 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28514879/growth-restriction-identifying-fetuses-at-risk
#4
Heidi K Leftwich, Bethany Stetson, Bethany Sabol, Katherine Leung, Judith U Hibbard, Isabelle Wilkins
PURPOSE: Examine risks of intrauterine growth restriction (IUGR) and composite perinatal outcomes with estimated fetal weights (EFW) 10-20(th)%, and compare outcomes using umbilical artery Doppler (UAD). MATERIALS AND METHODS: Retrospective, cohort evaluating ultrasound (US) EFW 10th-20(th)%, between 2002-2012. Cases were identified with EFW % 10-20. Controls, EFW >20(th)% were obtained for each case, matched by gestational age and US date. Unadjusted and adjusted logistic regression was used for outcomes...
May 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28497263/radiologic-head-ct-interpretation-errors-in-pediatric-abusive-and-non-abusive-head-trauma-patients
#5
Stephen F Kralik, Whitney Finke, Isaac C Wu, Roberta A Hibbard, Ralph A Hicks, Chang Y Ho
BACKGROUND: Pediatric head trauma, including abusive head trauma, is a significant cause of morbidity and mortality. OBJECTIVE: The purpose of this research was to identify and evaluate radiologic interpretation errors of head CTs performed on abusive and non-abusive pediatric head trauma patients from a community setting referred for a secondary interpretation at a tertiary pediatric hospital. MATERIALS AND METHODS: A retrospective search identified 184 patients <5 years of age with head CT for known or potential head trauma who had a primary interpretation performed at a referring community hospital by a board-certified radiologist...
May 11, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28428160/simulated-conversations-with-virtual-humans-to-improve-patient-provider-communication-and-reduce-unnecessary-prescriptions-for-antibiotics-a-repeated-measure-pilot-study
#6
Antoinette Schoenthaler, Glenn Albright, Judith Hibbard, Ron Goldman
BACKGROUND: Despite clear evidence that antibiotics do not cure viral infections, the problem of unnecessary prescribing of antibiotics in ambulatory care persists, and in some cases, prescribing patterns have increased. The overuse of antibiotics for treating viral infections has created numerous economic and clinical consequences including increased medical costs due to unnecessary hospitalizations, antibiotic resistance, disruption of gut bacteria, and obesity. Recent research has underscored the importance of collaborative patient-provider communication as a means to reduce the high rates of unnecessary prescriptions for antibiotics...
April 19, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/28405382/perceived-duration-of-brief-visual-events-is-mediated-by-timing-mechanisms-at-the-global-stages-of-visual-processing
#7
Lee Beattie, William Curran, Christopher P Benton, Julie M Harris, Paul B Hibbard
There is a growing body of evidence pointing to the existence of modality-specific timing mechanisms for encoding sub-second durations. For example, the duration compression effect describes how prior adaptation to a dynamic visual stimulus results in participants underestimating the duration of a sub-second test stimulus when it is presented at the adapted location. There is substantial evidence for the existence of both cortical and pre-cortical visual timing mechanisms; however, little is known about where in the processing hierarchy the cortical mechanisms are likely to be located...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28371586/the-psychiatrist-as-clinical-behavioural-scientist
#8
Richard Hibbard
No abstract text is available yet for this article.
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28330715/does-patient-activation-level-affect-the-cancer-patient-journey
#9
Judith H Hibbard, Eldon Mahoney, Ellen Sonet
OBJECTIVES: We assess how patient activation is associated with behaviors and experiences of people with cancer, including: understanding risks; making treatment decisions; communicating with providers; coping with symptoms; and adhering to regimens. METHODS: The study utilizes survey data from six surveys each including 500 cancer survivors. Multivariate analyses are presented. RESULTS: Higher activated patients are more than 9 times more likely to feel their treatment plans reflect their values, 4...
March 16, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28236132/double-read-of-skeletal-surveys-in-suspected-non-accidental-trauma-what-we-learned
#10
Boaz Karmazyn, Elise M Miller, Sara E Lay, James M Massey, Matthew R Wanner, Megan B Marine, S Gregory Jennings, Fangqian Ouyang, Roberta A Hibbard
BACKGROUND: Missing a fracture in a child on skeletal surveys for suspected non-accidental trauma can have devastating results. Double-read has the potential to improve fracture detection. However the yield of double-read is unknown. OBJECTIVE: To determine the advantage of double-read versus single-read of radiographic skeletal surveys for suspected non-accidental trauma. MATERIALS AND METHODS: The study was performed in two phases. In the first phase (April 2013 to September 2013), double-read was performed for all skeletal surveys obtained during weekday working hours...
February 24, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28183837/diagnostic-performance-of-ultrafast-brain-mri-for-evaluation-of-abusive-head-trauma
#11
S F Kralik, M Yasrebi, N Supakul, C Lin, L G Netter, R A Hicks, R A Hibbard, L L Ackerman, M L Harris, C Y Ho
BACKGROUND AND PURPOSE: MR imaging with sedation is commonly used to detect intracranial traumatic pathology in the pediatric population. Our purpose was to compare nonsedated ultrafast MR imaging, noncontrast head CT, and standard MR imaging for the detection of intracranial trauma in patients with potential abusive head trauma. MATERIALS AND METHODS: A prospective study was performed in 24 pediatric patients who were evaluated for potential abusive head trauma...
February 9, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28159442/does-patient-activation-predict-the-course-of-type-2-diabetes-a-longitudinal-study
#12
Rebecca M Sacks, Jessica Greene, Judith Hibbard, Valerie Overton, Carmen D Parrotta
OBJECTIVE: To examine whether patient activation is predictive of the course of diabetes over a three year period among patients with and without diabetes. METHODS: Longitudinal analyses utilized electronic health record data from 2011 to 2014. We examined how the patient activation measure (PAM) was predictive of 2014 diabetes-related outcomes among patients with diabetes (n=10,071); pre-diabetes (n=1804); and neither diabetes nor pre-diabetes (n=46,402). Outcomes were clinical indicators (blood pressure, cholesterol, and trigylcerides), costly utilization, and progression from no diabetes to pre-diabetes or diabetes...
January 25, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/27910487/combined-neutron-and-x-ray-imaging-at-the-national-ignition-facility-invited
#13
C R Danly, K Christensen, V E Fatherley, D N Fittinghoff, G P Grim, R Hibbard, N Izumi, D Jedlovec, F E Merrill, D W Schmidt, R A Simpson, K Skulina, P L Volegov, C H Wilde
X-ray and neutrons are commonly used to image inertial confinement fusion implosions, providing key diagnostic information on the fuel assembly of burning deuterium-tritium (DT) fuel. The x-ray and neutron data provided are complementary as the production of neutrons and x-rays occurs from different physical processes, but typically these two images are collected from different views with no opportunity for co-registration of the two images. Neutrons are produced where the DT fusion fuel is burning; X-rays are produced in regions corresponding to high temperatures...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910456/two-color-spatial-and-temporal-temperature-measurements-using-a-streaked-soft-x-ray-imager
#14
A S Moore, J Benstead, M F Ahmed, J Morton, T M Guymer, R Soufli, T Pardini, R L Hibbard, C G Bailey, P M Bell, S Hau-Riege, M Bedzyk, M J Shoup, S P Regan, T Agliata, R Jungquist, D W Schmidt, L B Kot, W J Garbett, M S Rubery, J W Skidmore, E Gullikson, F Salmassi
A dual-channel streaked soft x-ray imager has been designed and used on high energy-density physics experiments at the National Ignition Facility. This streaked imager creates two images of the same x-ray source using two slit apertures and a single shallow angle reflection from a nickel mirror. Thin filters are used to create narrow band pass images at 510 eV and 360 eV. When measuring a Planckian spectrum, the brightness ratio of the two images can be translated into a color-temperature, provided that the spectral sensitivity of the two images is well known...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910447/design-of-the-polar-neutron-imaging-aperture-for-use-at-the-national-ignition-facility
#15
V E Fatherley, D A Barker, D N Fittinghoff, R L Hibbard, J I Martinez, F E Merrill, J A Oertel, D W Schmidt, P L Volegov, C H Wilde
The installation of a neutron imaging diagnostic with a polar view at the National Ignition Facility (NIF) required design of a new aperture, an extended pinhole array (PHA). This PHA is different from the pinhole array for the existing equatorial system due to significant changes in the alignment and recording systems. The complex set of component requirements, as well as significant space constraints in its intended location, makes the design of this aperture challenging. In addition, lessons learned from development of prior apertures mandate careful aperture metrology prior to first use...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27824895/binocular-depth-judgments-on-smoothly-curved-surfaces
#16
Rebecca L Hornsey, Paul B Hibbard, Peter Scarfe
Binocular disparity is an important cue to depth, allowing us to make very fine discriminations of the relative depth of objects. In complex scenes, this sensitivity depends on the particular shape and layout of the objects viewed. For example, judgments of the relative depths of points on a smoothly curved surface are less accurate than those for points in empty space. It has been argued that this occurs because depth relationships are represented accurately only within a local spatial area. A consequence of this is that, when judging the relative depths of points separated by depth maxima and minima, information must be integrated across separate local representations...
2016: PloS One
https://www.readbyqxmd.com/read/27741201/outcomes-with-cerclage-alone-compared-with-cerclage-plus-17%C3%AE-hydroxyprogesterone-caproate
#17
COMPARATIVE STUDY
Bethany Stetson, Judith U Hibbard, Isabelle Wilkins, Heidi Leftwich
OBJECTIVE: To examine the differences in perinatal outcomes among women with a prior preterm birth who received cerclage compared with cerclage plus 17α-hydroxyprogesterone caproate. METHODS: Women with transvaginal cerclage placement and a prior delivery between 16 and 36 weeks of gestation were identified over a 10-year period (July 2002 to May 2012) in this retrospective cohort study. Exclusion criteria were delivery at another institution, abdominal cerclage, multiple gestations, and major fetal anomalies...
November 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27594306/how-much-do-clinicians-support-patient-self-management-the-development-of-a-measure-to-assess-clinician-self-management-support
#18
Jessica Greene, Rebecca M Sacks, Judith H Hibbard, Valerie Overton
BACKGROUND: Primary care provider (PCP) support of patient self-management may be important mechanism to improving patient health outcomes. In this paper we develop a PCP-reported measure of clinician strategies for supporting patient self-management, and we psychometrically test and validate the measure. METHODS: We developed survey items based upon effective self-management support strategies identified in a prior mixed methods study. We fielded a survey in the fall of 2014 with 139 Fairview Health Services PCPs, and conducted exploratory factor analysis and Cronbach's Alpha to test for scale reliability...
September 2, 2016: Healthcare
https://www.readbyqxmd.com/read/27562960/principles-and-practices-fostering-inclusive-excellence-lessons-from-the-howard-hughes-medical-institute-s-capstone-institutions
#19
Patricia Marten DiBartolo, Leslie Gregg-Jolly, Deborah Gross, Cathryn A Manduca, Ellen Iverson, David B Cooke, Gregory K Davis, Cameron Davidson, Paul E Hertz, Lisa Hibbard, Shubha K Ireland, Catherine Mader, Aditi Pai, Shirley Raps, Kathleen Siwicki, Jim E Swartz
Best-practices pedagogy in science, technology, engineering, and mathematics (STEM) aims for inclusive excellence that fosters student persistence. This paper describes principles of inclusivity across 11 primarily undergraduate institutions designated as Capstone Awardees in Howard Hughes Medical Institute's (HHMI) 2012 competition. The Capstones represent a range of institutional missions, student profiles, and geographical locations. Each successfully directed activities toward persistence of STEM students, especially those from traditionally underrepresented groups, through a set of common elements: mentoring programs to build community; research experiences to strengthen scientific skill/identity; attention to quantitative skills; and outreach/bridge programs to broaden the student pool...
December 0: CBE Life Sciences Education
https://www.readbyqxmd.com/read/27546032/improving-population-health-management-strategies-identifying-patients-who-are-more-likely-to-be-users-of-avoidable-costly-care-and-those-more-likely-to-develop-a-new-chronic-disease
#20
Judith H Hibbard, Jessica Greene, Rebecca M Sacks, Valerie Overton, Carmen Parrotta
OBJECTIVE: To explore using the Patient Activation Measure (PAM) for identifying patients more likely to have ambulatory care-sensitive (ACS) utilization and future increases in chronic disease. DATA SOURCES: Secondary data are extracted from the electronic health record of a large accountable care organization. STUDY DESIGN: This is a retrospective cohort design. The key predictor variable, PAM score, is measured in 2011, and is used to predict outcomes in 2012-2014...
August 22, 2016: Health Services Research
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