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https://www.readbyqxmd.com/read/28912376/a-recombinant-human-adamts-13-first-in-human-study-evaluating-pharmacokinetics-safety-and-tolerability-in-cttp-patients
#1
Marie Scully, Paul Knöbl, Karim Kentouche, Lawrence Rice, Jerzy Windyga, Reinhard Schneppenheim, Johanna A Kremer Hovinga, Michiko Kajiwara, Yoshihiro Fujimura, Caterina Maggiore, Jennifer Doralt, Christopher Hibbard, Leah Martell, Bruce Ewenstein
Safety, tolerability and pharmacokinetics of recombinant ADAMTS-13 (rADAMTS-13; BAX 930; SHP655) were investigated in 15 patients diagnosed with severe congenital ADAMTS-13 deficiency (plasma ADAMTS-13 activity < 6%) in a prospective phase 1, first-in-human, multicenter dose escalation study. BAX 930 was well tolerated, no serious adverse events occurred, and no anti-ADAMTS-13 antibodies were observed. Following single dose administration of BAX 930 at 5, 20, or 40 U/kg body weight to adolescents and adults, there was approximate dose proportionality with respect to Cmax and AUC...
September 14, 2017: Blood
https://www.readbyqxmd.com/read/28891386/testing-a-personal-narrative-for-persuading-people-to-value-and-use-comparative-physician-quality-of-care-information-an-experimental-study
#2
Jessica Greene, Judith H Hibbard, Rebecca M Sacks
OBJECTIVE: This study tests whether a personal narrative can persuade people to value comparative data on physician quality. METHOD: We conducted an online experiment with 850 adults. One group viewed a cartoon narrative on physician quality variation, another saw text on physician quality variation, and there was a control group. Study participants hypothetically selected a physician from a display of four physicians. The top-quality physician was furthest away and most expensive...
September 1, 2017: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/28888317/hypertrophic-burn-scar-research-from-quantitative-assessment-to-designing-clinical-sequential-multiple-assignment-randomized-trials
#3
REVIEW
Paul Diegidio, Steven Hermiz, Jonathan Hibbard, Michael Kosorok, Charles Scott Hultman
This article explores the current options for the quantitative assessment of hypertrophic burn scars. It also introduces a novel type of randomized, controlled trial, which relies on heterogeneity of the subject population to improve the predictive value of personalized treatment strategies.
October 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28887069/better-respiratory-education-and-treatment-help-empower-breathe-study-methodology-and-baseline-characteristics-of-a-randomized-controlled-trial-testing-a-transitional-care-program-to-improve-patient-centered-care-delivery-among-chronic-obstructive-pulmonary
#4
H Aboumatar, M Naqibuddin, S Chung, H Adebowale, L Bone, T Brown, L A Cooper, A P Gurses, A Knowlton, D Kurtz, L Piet, N Putcha, C Rand, D Roter, E Shattuck, C Sylvester, A Urteaga-Fuentes, R Wise, J L Wolff, T Yang, J Hibbard, E Howell, M Myers, K Shea, J Sullivan, L Syron, Wang Nae-Yuh, P Pronovost
BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of hospitalizations. Interventional studies focusing on the hospital-to-home transition for COPD patients are few. In the BREATHE (Better Respiratory Education and Treatment Help Empower) study, we developed and tested a patient and family-centered transitional care program that helps prepare hospitalized COPD patients and their family caregivers to manage COPD at home. METHODS: In the study's initial phase, we co-developed the BREATHE transitional care program with COPD patients, family-caregivers, and stakeholders...
September 5, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28857881/commentary-on-refining-consumer-engagement-definitions-and-strategies
#5
Judith H Hibbard
No abstract text is available yet for this article.
October 2017: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/28695529/summation-of-visual-attributes-in-auditory-visual-crossmodal-correspondences
#6
Clare Jonas, Mary Jane Spiller, Paul Hibbard
Crossmodal correspondences are a feature of human perception in which two or more sensory dimensions are linked together; for example, high-pitched noises may be more readily linked with small than with large objects. However, no study has yet systematically examined the interaction between different visual-auditory crossmodal correspondences. We investigated how the visual dimensions of luminance, saturation, size, and vertical position can influence decisions when matching particular visual stimuli with high-pitched or low-pitched auditory stimuli...
July 10, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28631114/derivatization-of-dextran-for-multiply-charged-ion-formation-and-electrospray-ionization-time-of-flight-mass-spectrometric-analysis
#7
Jesus B Tapia, Hailey A J Hibbard, Melissa M Reynolds
We present the use of a simple, one-pot derivatization to allow the polysaccharide dextran to carry multiple positive charges, shifting its molecular weight distribution to a lower m/z range. We performed this derivatization because molecular weight measurements of polysaccharides by mass spectrometry are challenging because of their lack of readily ionizable groups. The absence of ionizable groups limits proton abstraction and suppresses proton adduction during the ionization process, producing mass spectra with predominantly singly charged metal adduct ions, thereby limiting the detection of large polysaccharides...
June 19, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28603771/magnitude-precision-and-realism-of-depth-perception-in-stereoscopic-vision
#8
Paul B Hibbard, Alice E Haines, Rebecca L Hornsey
Our perception of depth is substantially enhanced by the fact that we have binocular vision. This provides us with more precise and accurate estimates of depth and an improved qualitative appreciation of the three-dimensional (3D) shapes and positions of objects. We assessed the link between these quantitative and qualitative aspects of 3D vision. Specifically, we wished to determine whether the realism of apparent depth from binocular cues is associated with the magnitude or precision of perceived depth and the degree of binocular fusion...
2017: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/28520900/accelerating-high-dimensional-clustering-with-lossless-data-reduction
#9
Bahjat F Qaqish, Jonathon J O'Brien, Jonathan C Hibbard, Katie J Clowers
Motivation: For cluster analysis, high-dimensional data are associated with instability, decreased classification accuracy and high-computational burden. The latter challenge can be eliminated as a serious concern. For applications where dimension reduction techniques are not implemented, we propose a temporary transformation which accelerates computations with no loss of information. The algorithm can be applied for any statistical procedure depending only on Euclidean distances and can be implemented sequentially to enable analyses of data that would otherwise exceed memory limitations...
September 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28514879/growth-restriction-identifying-fetuses-at-risk
#10
Heidi K Leftwich, Bethany Stetson, Bethany Sabol, Katherine Leung, Judith U Hibbard, Isabelle Wilkins
PURPOSE: Examine risks of intrauterine growth restriction (IUGR) and composite perinatal outcomes with estimated fetal weights (EFW) 10-20(th)%, and compare outcomes using umbilical artery Doppler (UAD). MATERIALS AND METHODS: Retrospective, cohort evaluating ultrasound (US) EFW 10th-20(th)%, between 2002-2012. Cases were identified with EFW % 10-20. Controls, EFW >20(th)% were obtained for each case, matched by gestational age and US date. Unadjusted and adjusted logistic regression was used for outcomes...
May 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28497263/radiologic-head-ct-interpretation-errors-in-pediatric-abusive-and-non-abusive-head-trauma-patients
#11
Stephen F Kralik, Whitney Finke, Isaac C Wu, Roberta A Hibbard, Ralph A Hicks, Chang Y Ho
BACKGROUND: Pediatric head trauma, including abusive head trauma, is a significant cause of morbidity and mortality. OBJECTIVE: The purpose of this research was to identify and evaluate radiologic interpretation errors of head CTs performed on abusive and non-abusive pediatric head trauma patients from a community setting referred for a secondary interpretation at a tertiary pediatric hospital. MATERIALS AND METHODS: A retrospective search identified 184 patients <5 years of age with head CT for known or potential head trauma who had a primary interpretation performed at a referring community hospital by a board-certified radiologist...
May 11, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28428160/simulated-conversations-with-virtual-humans-to-improve-patient-provider-communication-and-reduce-unnecessary-prescriptions-for-antibiotics-a-repeated-measure-pilot-study
#12
Antoinette Schoenthaler, Glenn Albright, Judith Hibbard, Ron Goldman
BACKGROUND: Despite clear evidence that antibiotics do not cure viral infections, the problem of unnecessary prescribing of antibiotics in ambulatory care persists, and in some cases, prescribing patterns have increased. The overuse of antibiotics for treating viral infections has created numerous economic and clinical consequences including increased medical costs due to unnecessary hospitalizations, antibiotic resistance, disruption of gut bacteria, and obesity. Recent research has underscored the importance of collaborative patient-provider communication as a means to reduce the high rates of unnecessary prescriptions for antibiotics...
April 19, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/28405382/perceived-duration-of-brief-visual-events-is-mediated-by-timing-mechanisms-at-the-global-stages-of-visual-processing
#13
Lee Beattie, William Curran, Christopher P Benton, Julie M Harris, Paul B Hibbard
There is a growing body of evidence pointing to the existence of modality-specific timing mechanisms for encoding sub-second durations. For example, the duration compression effect describes how prior adaptation to a dynamic visual stimulus results in participants underestimating the duration of a sub-second test stimulus when it is presented at the adapted location. There is substantial evidence for the existence of both cortical and pre-cortical visual timing mechanisms; however, little is known about where in the processing hierarchy the cortical mechanisms are likely to be located...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28371586/the-psychiatrist-as-clinical-behavioural-scientist
#14
Richard Hibbard
No abstract text is available yet for this article.
August 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28330715/does-patient-activation-level-affect-the-cancer-patient-journey
#15
Judith H Hibbard, Eldon Mahoney, Ellen Sonet
OBJECTIVES: We assess how patient activation is associated with behaviors and experiences of people with cancer, including: understanding risks; making treatment decisions; communicating with providers; coping with symptoms; and adhering to regimens. METHODS: The study utilizes survey data from six surveys each including 500 cancer survivors. Multivariate analyses are presented. RESULTS: Higher activated patients are more than 9 times more likely to feel their treatment plans reflect their values, 4...
March 16, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28236132/double-read-of-skeletal-surveys-in-suspected-non-accidental-trauma-what-we-learned
#16
Boaz Karmazyn, Elise M Miller, Sara E Lay, James M Massey, Matthew R Wanner, Megan B Marine, S Gregory Jennings, Fangqian Ouyang, Roberta A Hibbard
BACKGROUND: Missing a fracture in a child on skeletal surveys for suspected non-accidental trauma can have devastating results. Double-read has the potential to improve fracture detection. However the yield of double-read is unknown. OBJECTIVE: To determine the advantage of double-read versus single-read of radiographic skeletal surveys for suspected non-accidental trauma. MATERIALS AND METHODS: The study was performed in two phases. In the first phase (April 2013 to September 2013), double-read was performed for all skeletal surveys obtained during weekday working hours...
February 24, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28183837/diagnostic-performance-of-ultrafast-brain-mri-for-evaluation-of-abusive-head-trauma
#17
S F Kralik, M Yasrebi, N Supakul, C Lin, L G Netter, R A Hicks, R A Hibbard, L L Ackerman, M L Harris, C Y Ho
BACKGROUND AND PURPOSE: MR imaging with sedation is commonly used to detect intracranial traumatic pathology in the pediatric population. Our purpose was to compare nonsedated ultrafast MR imaging, noncontrast head CT, and standard MR imaging for the detection of intracranial trauma in patients with potential abusive head trauma. MATERIALS AND METHODS: A prospective study was performed in 24 pediatric patients who were evaluated for potential abusive head trauma...
February 9, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28159442/does-patient-activation-predict-the-course-of-type-2-diabetes-a-longitudinal-study
#18
Rebecca M Sacks, Jessica Greene, Judith Hibbard, Valerie Overton, Carmen D Parrotta
OBJECTIVE: To examine whether patient activation is predictive of the course of diabetes over a three year period among patients with and without diabetes. METHODS: Longitudinal analyses utilized electronic health record data from 2011 to 2014. We examined how the patient activation measure (PAM) was predictive of 2014 diabetes-related outcomes among patients with diabetes (n=10,071); pre-diabetes (n=1804); and neither diabetes nor pre-diabetes (n=46,402). Outcomes were clinical indicators (blood pressure, cholesterol, and trigylcerides), costly utilization, and progression from no diabetes to pre-diabetes or diabetes...
January 25, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/27910487/combined-neutron-and-x-ray-imaging-at-the-national-ignition-facility-invited
#19
C R Danly, K Christensen, V E Fatherley, D N Fittinghoff, G P Grim, R Hibbard, N Izumi, D Jedlovec, F E Merrill, D W Schmidt, R A Simpson, K Skulina, P L Volegov, C H Wilde
X-ray and neutrons are commonly used to image inertial confinement fusion implosions, providing key diagnostic information on the fuel assembly of burning deuterium-tritium (DT) fuel. The x-ray and neutron data provided are complementary as the production of neutrons and x-rays occurs from different physical processes, but typically these two images are collected from different views with no opportunity for co-registration of the two images. Neutrons are produced where the DT fusion fuel is burning; X-rays are produced in regions corresponding to high temperatures...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910456/two-color-spatial-and-temporal-temperature-measurements-using-a-streaked-soft-x-ray-imager
#20
A S Moore, J Benstead, M F Ahmed, J Morton, T M Guymer, R Soufli, T Pardini, R L Hibbard, C G Bailey, P M Bell, S Hau-Riege, M Bedzyk, M J Shoup, S P Regan, T Agliata, R Jungquist, D W Schmidt, L B Kot, W J Garbett, M S Rubery, J W Skidmore, E Gullikson, F Salmassi
A dual-channel streaked soft x-ray imager has been designed and used on high energy-density physics experiments at the National Ignition Facility. This streaked imager creates two images of the same x-ray source using two slit apertures and a single shallow angle reflection from a nickel mirror. Thin filters are used to create narrow band pass images at 510 eV and 360 eV. When measuring a Planckian spectrum, the brightness ratio of the two images can be translated into a color-temperature, provided that the spectral sensitivity of the two images is well known...
November 2016: Review of Scientific Instruments
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