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https://www.readbyqxmd.com/read/29778885/effects-of-hyperpolypharmacy-and-potentially-inappropriate-medications-pims-on-functional-decline-in-older-patients-discharged-from-acute-care-hospitals
#1
Paolo Fabbietti, Carmelinda Ruggiero, Federica Sganga, Sergio Fusco, Federica Mammarella, Norma Barbini, Laura Cassetta, Graziano Onder, Andrea Corsonello, Fabrizia Lattanzio, Mirko Di Rosa
AIM: To comparatively investigate the effects of hyperpolypharmacy and potentially inappropriate medications (PIMs) on functional decline in older patients after hospital discharge. METHODS: Our series consisted of 733 patients aged ≥65 consecutively enrolled in a multicenter observational longitudinal study. PIMs were defined on the basis of updated versions of Beers and STOPP criteria. The occurrence of functional decline was defined as the loss of independency in at least 1 basic activity of daily living (BADL) from discharge through 3-month follow-up visit...
May 16, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29774846/occupation-associated-fatal-limbic-encephalitis-caused-by-variegated-squirrel-bornavirus-1-germany-2013
#2
Dennis Tappe, Kore Schlottau, Daniel Cadar, Bernd Hoffmann, Lorenz Balke, Burkhard Bewig, Donata Hoffmann, Philip Eisermann, Helmut Fickenscher, Andi Krumbholz, Helmut Laufs, Monika Huhndorf, Maria Rosenthal, Walter Schulz-Schaeffer, Gabriele Ismer, Sven-Kevin Hotop, Mark Brönstrup, Anthonina Ott, Jonas Schmidt-Chanasit, Martin Beer
Limbic encephalitis is commonly regarded as an autoimmune-mediated disease. However, after the recent detection of zoonotic variegated squirrel bornavirus 1 in a Prevost's squirrel (Callosciurus prevostii) in a zoo in northern Germany, we retrospectively investigated a fatal case in an autoantibody-seronegative animal caretaker who had worked at that zoo. The virus had been discovered in 2015 as the cause of a cluster of cases of fatal encephalitis among breeders of variegated squirrels (Sciurus variegatoides) in eastern Germany...
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29773179/some-bottled-water-may-be-salubrious
#3
Leslie M Klevay
Hard drinking water seems protective against cardiovascular disease compared to soft water. Published data on calcium and magnesium in bottled water products were evaluated to determine water hardness. Data on water chemistry of thirty-three products were obtained from the internet and hardness, as calcium carbonate, was calculated. Approximately two thirds of the products were soft according to criteria of the US Geological Survey; only one fifth were very hard. Beer and wine also were found to be very hard...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29773071/endometrial-cancer-how-many-patients-could-benefit-from-sentinel-lymph-node-dissection
#4
Sarah Brugger, Moritz Hamann, Marc Mosner, Michaela Beer, Michael Braun, Martin Pölcher
BACKGROUND: Sentinel lymph node dissection (SLND) may reduce morbidity in patients with endometrial cancer. The objective of this study is to estimate how many systematic lymph node dissections (LND) can be spared with an implementation of a SLN-procedure. METHODS: Retrospective, single-center study, SLND according to NCCN-Guidelines. RESULTS: In 109 patients of 154 consecutive patients, SLND was performed. The detection rate was 61% on both sides and 86% on at least one side...
May 17, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29771941/efficacy-of-ivermectin-mass-drug-administration-to-control-scabies-in-asylum-seekers-in-the-netherlands-a-retrospective-cohort-study-between-january-2014-march-2016
#5
Dorien T Beeres, Sofanne J Ravensbergen, Annelies Heidema, Darren Cornish, Machiel Vonk, Leonie D Wijnholds, Jessica J H Hendriks, Johanneke Kleinnijenhuis, Till F Omansen, Ymkje Stienstra
Scabies is a skin infestation with the mite Sarcoptes scabiei causing itch and rash and is a major risk factor for bacterial skin infections and severe complications. Here, we evaluated the treatment outcome of 2866 asylum seekers who received (preventive) scabies treatment before and during a scabies intervention programme (SIP) in the main reception centre in the Netherlands between January 2014 and March 2016. A SIP was introduced in the main national reception centre based on frequent observations of scabies and its complications amongst Eritrean and Ethiopian asylum seekers in the Netherlands...
May 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29771561/mood-selectively-moderates-the-implicit-alcohol-association-drinking-relation-in-college-student-heavy-episodic-drinkers
#6
Kristen P Lindgren, Jason J Ramirez, Reinout W Wiers, Bethany A Teachman, Jeanette Norris, Cecilia C Olin, Melissa L Gasser, Debra Kaysen, Clayton Neighbors
Multiple studies indicate that implicit alcohol-related associations (i.e., indices of relatively fast, spontaneous processes) predict drinking. An important next step is to investigate moderators of the implicit association-drinking relationship. Mood state has been proposed as a moderator of this relationship: implicit associations have been theorized to be stronger predictors of drinking under positive mood states. From the same theoretical perspective, explicit measures (indices of relatively slow, reflective processes) have been proposed to be stronger predictors of drinking under negative mood states...
May 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29768665/chiral-separation-of-isoxanthohumol-and-8-prenylnaringenin-in-beer-hop-pellets-and-hops-by-hplc-with-chiral-columns
#7
Hyuga Moriya, Sohei Tanaka, Yukari Iida, Satomi Kitagawa, Sen-Ichi Aizawa, Atsushi Taga, Hiroyuki Terashima, Atsushi Yamamoto, Shuji Kodama
Xanthohumol, isoxanthohumol, and 8-prenylnaringenin in beer, hop, and hop pellet samples were analyzed by HPLC using InertSustain phenyl column and the mobile phase containing 40% methanol and 12% 2-propanol. Fractions of isoxanthohumol and 8-prenylnaringenin obtained by the above HPLC were separately collected. Isoxanthohumol and 8-prenylnaringenin were enantioseparated by HPLC using Chiralcel OD-H column with a mobile phase composed of hexane/ethanol (90/10, v/v) and Chiralpak AD-RH column with a mobile phase composed of methanol/2-propanol/water (40/20/40, v/v/v), respectively...
May 16, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29768396/acute-cardiovascular-responses-elicited-by-consumption-of-beer-in-healthy-people
#8
Karolina Adamska, Tomasz Krauze, Przemysław Guzik, Jarosław Piskorski, Krzysztof Klimas, Andrzej Wykrętowicz
No abstract text is available yet for this article.
May 16, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29767640/burden-of-exposure-to-potential-interactions-between-antiretroviral-and-non-antiretroviral-medications-in-a-population-of-hiv-positive-patients-aged-50-years-or-older
#9
Alice Ranzani, Letizia Oreni, Massimiliano Agrò, Lorena van den Bogaart, Laura Milazzo, Andrea Giacomelli, Dario Cattaneo, Cristina Gervasoni, Anna Lisa Ridolfo
BACKGROUND: As HIV-infected patients aged 50 years or older are at increased risk of comorbidities and multidrug treatments, we examined their exposure to the potential drug-drug interactions (PDDIs) of antiretroviral (ARV) and other medications. METHODS: This cross-sectional study involved the patients aged 50 years or older receiving ARV and non-ARV medications at our clinic. PDDIs were identified using the University of Liverpool HIV Drug Interaction Checker...
June 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29766595/highly-deficient-alcohol-health-warning-labels-in-a-high-income-country-with-a-voluntary-system
#10
Georges Tinawi, Tessa Gray, Thomas Knight, Chayce Glass, Nina Domanski, Nick Wilson, Janet Hoek, George Thomson
INTRODUCTION AND AIMS: To examine the prevalence and design elements of the voluntary health warning labels and related industry initiatives on a purposive sample of alcoholic beverage containers sold in New Zealand (NZ), a country with no mandatory health warning labels. DESIGN AND METHODS: We selected a purposive (e.g. low-cost) sample of 59 local and imported beers, wines and ready-to-drink alcoholic beverage containers available in NZ in 2016-2017. We documented the occurrence, content, size, appearance and position of messages concerning drinking during pregnancy, drink-driving, other health effects and industry-led initiatives that could relate to warnings; and collected data about alcohol content, standard drinks, ingredients and energy information...
May 15, 2018: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29764800/mindfulness-based-symptom-and-stress-management-apps-for-adults-with-chronic-lung-disease-systematic-search-in-app-stores
#11
REVIEW
Otis L Owens, Jenay M Beer, Ligia I Reyes, David G Gallerani, Amanda R Myhren-Bennett, Karen K McDonnell
BACKGROUND: Up to 70% of lung cancer survivors are affected by chronic obstructive pulmonary disease (COPD), a common, debilitating, comorbid disease. Lung cancer and COPD are both characterized by symptoms such as breathlessness, fatigue, and psychological distress. These distressing chronic symptoms are exacerbated by stress and detract from an individual's quality of life. OBJECTIVE: The aim of this study was to identify and evaluate evidence-based, commercially available apps for promoting mindfulness-based strategies among adults with a COPD or lung cancer history (ie, chronic lung disease)...
May 15, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29763455/correction-mrna-mediated-gene-supplementation-of-toll-like-receptors-as-treatment-strategy-for-asthma-in-vivo
#12
Franziska Zeyer, Benedikt Mothes, Clara Will, Melanie Carevic, Jennifer Rottenberger, Bernd Nürnberg, Dominik Hartl, Rupert Handgretinger, Sandra Beer-Hammer, Michael S D Kormann
[This corrects the article DOI: 10.1371/journal.pone.0154001.].
2018: PloS One
https://www.readbyqxmd.com/read/29755448/low-light-anoxygenic-photosynthesis-and-fe-s-biogeochemistry-in-a-microbial-mat
#13
Sebastian Haas, Dirk de Beer, Judith M Klatt, Artur Fink, Rebecca McCauley Rench, Trinity L Hamilton, Volker Meyer, Brian Kakuk, Jennifer L Macalady
We report extremely low-light-adapted anoxygenic photosynthesis in a thick microbial mat in Magical Blue Hole, Abaco Island, The Bahamas. Sulfur cycling was reduced by iron oxides and organic carbon limitation. The mat grows below the halocline/oxycline at 30 m depth on the walls of the flooded sinkhole. In situ irradiance at the mat surface on a sunny December day was between 0.021 and 0.084 μmol photons m-2 s-1 , and UV light (<400 nm) was the most abundant part of the spectrum followed by green wavelengths (475-530 nm)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29754606/a-comparison-study-of-nanofiber-microfiber-and-new-composite-nano-microfiber-polymers-used-as-sorbents-for-on-line-solid-phase-extraction-in-chromatography-system
#14
Martina Háková, Lucie Chocholoušová Havlíková, Jiří Chvojka, Jakub Erben, Petr Solich, František Švec, Dalibor Šatínský
Three different approaches has been used to obtain nano/micro fibers and their diversity and extraction properties were examined. The effect of their structure on stability in an ultra-high-performance liquid chromatography (UHPLC) system during on-line SPE procedure was monitored. Five types of various nano/micro fiber polymers were used as sorbents: polyamide 6 nanofibers, polyvinylidene difluoride nanofibers, polyethylene microfibers, and two new polycaprolactone microfiber/nanofiber and polycaprolactone microfibers/polyvinylidene difluoride nanofibers composite polymers...
September 6, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29753297/a-clinical-trial-of-nurse-practitioner-care-in-residential-aged-care-facilities
#15
Glenn Arendts, Pamela Deans, Keith O'Brien, Christopher Etherton-Beer, Kirsten Howard, Gill Lewin, Moira Sim
BACKGROUND: Optimising quality of life and reducing hospitalisation for people living in residential aged care facilities (RACF) are important health policy goals. METHODS: A cluster controlled clinical trial of nurse practitioner care in RACF. Six facilities were included: three randomly allocated to intervention where nurse practitioners working with general practitioners and using a best practice guide were responsible for care, and three control. Participants were followed up for a minimum of 12 months unless dead or transferred to another facility...
May 4, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29751021/a-new-era-of-virus-bioinformatics
#16
REVIEW
Bashar Ibrahim, Dino P McMahon, Franziska Hufsky, Martin Beer, Li Deng, Philippe Le Mercier, Massimo Palmarini, Volker Thiel, Manja Marz
Despite the recognized excellence of virology and bioinformatics, these two communities have interacted surprisingly sporadically, aside from some pioneering work on HIV-1 and influenza. Bringing together the expertise of bioinformaticians and virologists is crucial, since very specific but fundamental computational approaches are required for virus research, particularly in an era of big data. Collaboration between virologists and bioinformaticians is necessary to improve existing analytical tools, cloud-based systems, computational resources, data sharing approaches, new diagnostic tools, and bioinformatic training...
May 8, 2018: Virus Research
https://www.readbyqxmd.com/read/29750643/analysis-of-protein-glycation-in-human-fingernail-clippings-with-near-infrared-nir-spectroscopy-as-an-alternative-technique-for-the-diagnosis-of-diabetes-mellitus
#17
Tinne Monteyne, Renaat Coopman, Antoine S Kishabongo, Jonas Himpe, Bruno Lapauw, Samyah Shadid, Elisabeth H Van Aken, Darja Berenson, Marijn M Speeckaert, Thomas De Beer, Joris R Delanghe
BACKGROUND: Glycated keratin allows the monitoring of average tissue glucose exposure over previous weeks. In the present study, we wanted to explore if near-infrared (NIR) spectroscopy could be used as a non-invasive diagnostic tool for assessing glycation in diabetes mellitus. METHODS: A total of 52 patients with diabetes mellitus and 107 healthy subjects were enrolled in this study. A limited number (n=21) of nails of healthy subjects were glycated in vitro with 0...
May 11, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29748236/modeling-and-predicting-tumor-response-in-radioligand-therapy
#18
Peter Kletting, Anne Thieme, Nina Eberhardt, Andreas Rinscheid, Calogero D'Alessandria, Jakob Allmann, Hans-Jürgen Wester, Robert Tauber, Ambros J Beer, Gerhard Glatting, Matthias Eiber
The aim of this work was to develop a theranostic method that allows predicting PSMA-positive tumor volume after radioligand therapy (RLT) based on a pre-therapeutic PET/CT measurement and physiologically based pharmacokinetic/dynamic (PBPK/PD) modeling at the example of RLT using 177 Lu-labeled PSMA for imaging and therapy (PSMA I&T). Methods: A recently developed PBPK model for 177 Lu PSMA I&T RLT was extended to account for tumor (exponential) growth and reduction due to irradiation (linear quadratic model)...
May 10, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29746116/yeast-metabolites-of-glycated-amino-acids-in-beer
#19
Michael Hellwig, Falco Beer, Sophia Witte, Thomas Henle
Glycation reactions (Maillard reactions) during the malting and brewing processes are important for the development of the characteristic color and flavor of beer. Recently, free and protein-bound Maillard reaction products (MRPs) such as pyrraline, formyline, and maltosine were found in beer. Furthermore, these amino acid derivatives are metabolized by Saccharomyces cerevisiae via the Ehrlich pathway. In this study, a method was developed for quantitation of individual Ehrlich intermediates derived from pyrraline, formyline, and maltosine...
May 10, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29744637/cancer-stage-and-pack-years-but-not-p16-or-hpv-are-relevant-for-survival-in-hypopharyngeal-and-laryngeal-squamous-cell-carcinomas
#20
Valerie Dahm, Andrea Haitel, Alexandra Kaider, Isabella Stanisz, Andrea Beer, Claudia Lill
PURPOSE: Recently, p16 has been included in the TNM guideline for oropharyngeal carcinomas. The role of HPV and p16 in hypopharyngeal and laryngeal carcinomas has not yet been established sufficiently. METHODS: Hundred and thirty-four patients with hypopharyngeal and laryngeal carcinomas were included in this retrospective analysis. Only patients with known HPV status were eligible for the investigation. Survival probabilities were estimated for different risk factors...
May 9, 2018: European Archives of Oto-rhino-laryngology
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