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Alexander Breitenstein, Simon F Stämpfli, Martin F Reiner, Yi Shi, Stephan Keller, Alexander Akhmedov, Ariane Schaub Clerigué, Remo D Spescha, Hans-Jürg Beer, Thomas F Lüscher, Felix C Tanner, Giovanni G Camici
Despite public awareness of its deleterious effects, smoking remains a major cause of death. Indeed, it is a risk factor for atherothrombotic complications and in line with this, the introduction of smoking ban in public areas reduced smoking-associated cardiovascular complications. Nonetheless, smoking remains a major concern, and molecular mechanisms by which it causes cardiovascular disease are not known. Peripheral blood monocytes from healthy smokers displayed increased JNK2 and tissue factor (TF) gene expression compared to non-smokers (n=15, p<0...
October 20, 2016: Thrombosis and Haemostasis
Rayssa Ferreira Zanatta, Maria Ângela Lacerda Rangel Esper, Marcia Carneiro Valera, Renata Marques Melo, Eduardo Bresciani
This study aimed to evaluate the effect of beers on the bovine enamel microhardness. Fifty rectangular (1 x 3 x 1 mm-height x width x thickness) enamel specimens were obtained from permanent bovine incisors, and divided into five groups (n = 10) according to the treatment employed: Saliva, Coke, Brahma, Heineken, and Budweiser. Microhardness (Knoop) were obtained before; after 5, 30 and 60 min of immersion in each solution. The data were analyzed using repeated two-way ANOVA and Tukey´s test (p<0.05). Coke decreased the microhardness in all immersion times, and Heineken, showed low values after 60 minutes...
2016: PloS One
Matthias Holzlechner, Katharina Strasser, Elitsa Zareva, Luise Steinhaeuser, Hanna Birnleitner, Andrea Beer, Michael Bergmann, Rudolf Oehler, Martina Marchetti-Deschmann
Tissue-resident immune cells differ from the corresponding blood cells in many functional aspects. Although the proteome of blood immune cells is well investigated there are almost no data on tissue-resident immune cells. Here we explored the potential of MALDI-TOF-MS imaging (MSI) to investigate these cells in colon tissue, which exhibits a strong immune infiltration. MSI identified several proteinaceous markers that colocalized with specific structures of the colon such as mucosa or muscularis mucosae in six patients...
October 18, 2016: Journal of Proteome Research
Katherine Wingert Pizarro, Inés V Bustamante, Pamela J Surkan
BACKGROUND: Family relationships are widely recognized as playing a role in adolescent alcohol use. Although family relationships and parenting vary by culture, limited research has explored these relationships in Latin America. OBJECTIVES: We sought to determine which family factors are associated with adolescent alcohol use in Callao, Peru. METHODS: Data come from a cross-sectional survey conducted in a public secondary school in Callao, Peru in 2007...
October 18, 2016: Substance Use & Misuse
Fawzia A Ibrahim, Amina M Elbrashy, Jenny Jeehan M Nasr, Mostafa M Badr El-Dien
Three different spectrophotometric and two spectrofluorimetric methods have been developed and validated for the determination of vincamine (VN) and naftidrofuryl oxalate (NF) in tablets. The spectrophotometric methods depend on charge transfer complex formation between each of VN and NF with 7,7,8,8-tetracyano-quinodimethane (TCNQ), 2,6-dichloroquinone-4-chloroimide (DCQ) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) at 843, 580 and 588 nm, respectively. The spectrofluorimetric methods are based on the formation of charge transfer complex between each of the two drugs and TCNQ, with measurement of the fluorophore formed at 312/375 and 284/612 nm, respectively, or with DDQ at 400/475 and 284/396 nm, respectively...
October 18, 2016: Luminescence: the Journal of Biological and Chemical Luminescence
Christoph Scherfler, Alois Josef Schiefecker, Margarete Delazer, Ronny Beer, Thomas Bodner, Georg Spinka, Mario Kofler, Bettina Pfausler, Christian Kremser, Michael Schocke, Thomas Benke, Elke R Gizewski, Erich Schmutzhard, Raimund Helbok
OBJECTIVE: MRI parameters of iron concentration (R2*, transverse relaxation rate), microstructural integrity (mean diffusivity and fractional anisotropy), as well as gray and white matter volumes were analyzed in patients with subarachnoid hemorrhage (SAH) and uncomplicated clinical course to detect the evolution of brain tissue changes 3 weeks and 12 months after ictus. METHODS: MRI scans of 14 SAH patients (aneurysm of the anterior communicating artery, n = 5; no aneurysm n = 9) were compared with 14 age-matched healthy control subjects...
October 2016: Annals of Clinical and Translational Neurology
Lotte E Couperus, Victoria Delgado, Meindert Palmen, Marieke E van Vessem, Jerry Braun, Marta Fiocco, Laurens F Tops, Harriëtte F Verwey, Robert J M Klautz, Martin J Schalij, Saskia L M A Beeres
OBJECTIVE: Several clinical and left ventricular parameters have been associated with prognosis after surgical left ventricular restoration in patients with ischemic heart failure. The aim of this study was to determine the prognostic value of right ventricular function. METHODS: A total of 139 patients with ischemic heart failure (62 ± 10 years; 79% were male; left ventricular ejection fraction 27% ± 7%) underwent surgical left ventricular restoration. Biventricular function was assessed with echocardiography before surgery...
September 23, 2016: Journal of Thoracic and Cardiovascular Surgery
James Y Wang, Gerard Nuovo, Mitchell Kline, Cynthia M Magro
Epithelial sheath neuroma is a rarely recognized but established entity in the medical literature. First described in 2000 by Requena et al, there have only been 7 published cases to date, mostly in female patients and presenting as symptomatic solitary lesions on the back without a known history of trauma. In 2006, Beer et al described and reviewed a dozen cases in which epithelial sheath neuroma-like features were seen in the advent of a surgical procedure, which was termed "re-excision perineural invasion" and attributed to possible eccrine duct implantation during surgery...
October 4, 2016: American Journal of Dermatopathology
Krystina Parker, Willy Aasebø, Knut Stavem
BACKGROUND: Polypharmacy is commonly applied to elderly haemodialysis patients for treating terminal renal failure and multiple co-morbidities. Potentially inappropriate medications (PIMs) in multidrug regimens in geriatric populations can be identified using specially designed screening tools. OBJECTIVE: The aims of this study were to estimate the prevalence of PIMs by applying the Screening Tool of Older Persons' Prescriptions (STOPP) criteria and the Beers criteria to elderly haemodialysis patients and to assess the association of some risk factors with the presence of PIMs...
September 2016: Drugs—Real World Outcomes
Bertram Gawronski, Jennifer S Beer
The distinction between utilitarianism and deontology has become a prevailing framework for conceptualizing moral judgment. According to the principle of utilitarianism, the morality of an action depends on its outcomes. In contrast, the principle of deontology states that the morality of an action depends on its consistency with moral norms. To identify the processes underlying utilitarian and deontological judgments, research in psychology and neuroscience has investigated responses to moral dilemmas that pit one principle against the other (e...
October 15, 2016: Social Neuroscience
Nicolas Faller, Andreas Limacher, Marie Méan, Marc Righini, Markus Aschwanden, Jürg Hans Beer, Beat Frauchiger, Josef Osterwalder, Nils Kucher, Bernhard Lämmle, Jacques Cornuz, Anne Angelillo-Scherrer, Christian M Matter, Marc Husmann, Martin Banyai, Daniel Staub, Lucia Mazzolai, Olivier Hugli, Nicolas Rodondi, Drahomir Aujesky
BACKGROUND: Long-term predictors and causes of death are understudied in elderly patients with acute venous thromboembolism. METHODS: We prospectively followed-up 991 patients aged ≥65 years with acute venous thromboembolism in a multicenter Swiss cohort study. The primary outcome was overall mortality. We explored the association between patient baseline characteristics and mortality, adjusting for other baseline variables and periods of anticoagulation as a time-varying co-variate...
October 11, 2016: American Journal of Medicine
Z Wilhelm de Beer, Seonju Marincowitz, Tuan A Duong, Jae-Jin Kim, Andre Rodrigues, Michael J Wingfield
There have been many recent studies using environmental nucleic acid sequences (ENAS) to assess fungal diversity. As a result, more than a third of all fungal sequences in GenBank are of environmental origin. But inconsistent annotation of the thousands of undescribed taxa represented by these sequences limits access to these data. Consequently, these ENAS and the taxa they represent are rarely considered in other studies, and especially not in taxonomic treatments. This problem is confounded by the fact that the current version of the International Code of Nomenclature for Algae, Fungi, and Plants (Melbourne Code) prohibits the description of novel taxa known only from ENAS...
November 2016: Fungal Biology
Christopher N Morrison, Beidi Dong, Charles C Branas, Therese S Richmond, Douglas J Wiebe
AIMS: This study estimated, with high spatial and temporal specificity, individuals' risk of being assaulted relative to their momentary proximity to alcohol outlets during daily activities. DESIGN: Case-control study. SETTING: Philadelphia, Pennsylvania, USA. PARTICIPANTS: Cases were 194 non-gun assault victims and 135 gun assault victims aged between 10 and 24 years. Age-matched controls (n = 274) were selected using random-digit dialing...
October 14, 2016: Addiction
Yongrui He, Xian-En Zhao, Renjun Wang, Na Wei, Jing Sun, Jun Dang, Guang Chen, Zhiqiang Liu, Shuyun Zhu, Jin-Mao You
A simple, rapid, sensitive, selective and environmentally friendly method, based on in situ derivatization ultrasound-assisted dispersive liquid-liquid microextraction (in situ DUADLLME) coupled with ultra high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) using multiple reaction monitoring (MRM) mode has been developed for the simultaneous determination of food-related biogenic amines and amino acids. A new mass spectrometry sensitive derivatization reagent 4'-carbonyl chloride rosamine (CCR) was designed, synthesized and firstly reported...
October 14, 2016: Journal of Agricultural and Food Chemistry
Huabo Wang, Jie Lu, Lia R Edmunds, Sucheta Kulkarni, James Dolezal, Junyan Tao, Sarangarajan Ranganathan, Laura Jackson, Marc Fromherz, Donna Beer Stolz, Radha Uppala, Sivakama Bharathi, Satdarshan P Monga, Eric S Goetzman, Edward V Prochownik
Hepatoblastoma (HB) is associated with aberrant activation of the β-catenin and Hippo/YAP signaling pathways. Over-expression of mutant β-catenin and YAP in mice induces HBs that express high levels of c-Myc (Myc). In light of recent observations that Myc in unnecessary for long-term hepatocyte proliferation, we have now examined its role in HB pathogenesis using the above model. While Myc was found to be dispensable for in vivo HB initiation it was necessary to sustain rapid tumor growth. Gene expression profiling identified key molecular differences between myc+/+ (WT) and myc-/- (KO) hepatocytes and HBs that explain these behaviors...
October 13, 2016: Journal of Biological Chemistry
Aastha Gupta, Sandeep Juneja, Marco Vitoria, Vincent Habiyambere, Boniface Dongmo Nguimfack, Meg Doherty, Daniel Low-Beer
With anti-retroviral treatment (ART) scale-up set to continue over the next few years it is of key importance that manufacturers and planners in low- and middle-income countries (LMICs) hardest hit by the HIV/AIDS pandemic are able to anticipate and respond to future changes to treatment regimens, generics pipeline and demand, in order to secure continued access to all ARV medicines required. We did a forecast analysis, using secondary WHO and UNAIDS data sources, to estimate the number of people living with HIV (PLHIV) and the market share and demand for a range of new and existing ARV drugs in LMICs up to 2025...
2016: PloS One
Yarong Zhao, Jianxiang Huang, Liyan Ma, Shuai Liu, Fuhua Wang
A total of 101 samples of beer from the Chinese market were analyzed for the presence of aflatoxin B1 (AFB1) and sterigmatocystin (STC), using methods based on liquid chromatography-tandem mass spectrometry (LC-MS/MS). The limit of quantification (LOQ) and the limit of detection (LOD) in beer were 0.1µg/kg and 0.03 µg/kg, respectively. Recoveries of AFB1 and STC from spiked beer samples were 97.8 - 103.6% and 92.7 - 102.1%, respectively. None of the beer purchased samples were contaminated with AFB1 or STC...
October 13, 2016: Food Additives & Contaminants. Part B, Surveillance
Rafael T Mikolajczyk, Rene Sebena, Julia Warich, Vihra Naydenova, Urszula Dudziak, Olga Orosova
BACKGROUND: Alcohol drinking was linked to self-rated health in different populations, but the observed association was inconsistent. We studied the association among university students across three European countries with different patterns of drinking. METHODS: We analyzed data from three universities, one from each country: Germany (beer dominant), Bulgaria (wine dominant), and Poland (unclassified among youths, spirits dominant in adults) (N = 2103). Frequency of drinking and problem drinking (≥2 positive responses on CAGE-scale), on the one side, and self-rated health, caring for one's own health, and worsening of health since the last year, on the other side, were assessed by means of self-administered questionnaire...
2016: Frontiers in Public Health
Werner Mäntele, Erhan Deniz
UV-VIS absorption spectroscopy is used in almost every spectroscopy laboratory for routine analysis or research. All spectroscopists rely on the Lambert-Beer Law but many of them are less aware of its limitations. This tutorial discusses typical problems in routine spectroscopy that come along with technical limitations or careless selection of experimental parameters. Simple rules are provided to avoid these problems.
September 21, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Alexander E Hess, Paul D Beer
Four halogen and hydrogen bonding rotaxane host systems featuring pyridinium bis-amide-iodotriazole/prototriazole and pyridinium bis-amide-iodotriazolium/prototriazolium axle components have been synthesized by CuAAC-mediated mono-stoppering chloride anion templation and post-rotaxanation methylation reactions. In competitive 45 : 45 : 10 CDCl3-CD3OD-D2O aqueous solvent media, the dicationic halogen bonding rotaxane displayed a notable enhanced binding affinity and marked selectivity for Br(-) over other halides and nitrate and dihydrogen phosphate oxoanions in contrast to an all hydrogen bonding counterpart which is attributed to chelated charge assisted halogen bonding interactions...
October 11, 2016: Organic & Biomolecular Chemistry
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