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https://www.readbyqxmd.com/read/28213842/determination-of-the-porosity-of-plga-microparticles-by-tracking-their-sedimentation-velocity-using-a-flow-imaging-microscope-flowcam
#1
A S Sediq, S K D Waasdorp, M R Nejadnik, M M C van Beers, J Meulenaar, R Verrijk, W Jiskoot
PURPOSE: To investigate whether particle sedimentation velocity tracking using a flow imaging microscope (FlowCAM) can be used to determine microparticle porosity. METHODS: Two different methods were explored. In the first method the sedimentation rate of microparticles was tracked in suspending media with different densities. The porosity was calculated from the average apparent density of the particles derived by inter- or extrapolation to the density of a suspending medium in which the sedimentation velocity was zero...
February 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28213821/prevalence-of-internalized-hiv-related-stigma-among-hiv-infected-adults-in-care-united-states-2011-2013
#2
Amy R Baugher, Linda Beer, Jennifer L Fagan, Christine L Mattson, Mark Freedman, Jacek Skarbinski, R Luke Shouse
HIV-infected U.S. adults have reported internalized HIV-related stigma; however, the national prevalence of stigma is unknown. We sought to determine HIV-related stigma prevalence among adults in care, describe which socio-demographic groups bear the greatest stigma burden, and assess the association between stigma and sustained HIV viral suppression. The Medical Monitoring Project measures characteristics of U.S. HIV-infected adults receiving care using a national probability sample. We used weighted data collected from June 2011 to May 2014 and assessed self-reported internalized stigma based on agreement with six statements...
February 14, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28213731/fungi-based-treatment-of-brewery-wastewater-biomass-production-and-nutrient-reduction
#3
M Hultberg, H Bodin
The beer-brewing process produces high amounts of nutrient-rich wastewater, and the increasing number of microbreweries worldwide has created a need for innovative solutions to deal with this waste. In the present study, fungal biomass production and the removal of organic carbon, phosphorus and nitrogen from synthetic brewery wastewater were studied. Different filamentous fungi with a record of safe use were screened for growth, and Trametes versicolor, Pleurotus ostreatus and Trichoderma harzianum were selected for further work...
February 17, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28213278/identifying-overarching-excipient-properties-towards-an-in-depth-understanding-of-process-and-product-performance-for-continuous-twin-screw-wet-granulation
#4
N Willecke, A Szepes, M Wunderlich, J P Remon, C Vervaet, T De Beer
The overall objective of this work is to understand how excipient characteristics influence the process and product performance for a continuous twin-screw wet granulation process. The knowledge gained through this study is intended to be used for a Quality by Design (QbD)-based formulation design approach and formulation optimization. A total of 9 preferred fillers and 9 preferred binders were selected for this study. The selected fillers and binders were extensively characterized regarding their physico-chemical and solid state properties using 21 material characterization techniques...
February 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28211908/the-n-terminal-domain-of-schmallenberg-virus-envelope-protein-gc-is-highly-immunogenic-and-can-provide-protection-from-infection
#5
Kerstin Wernike, Andrea Aebischer, Gleyder Roman-Sosa, Martin Beer
Schmallenberg virus (SBV) is transmitted by insect vectors, and therefore vaccination is one of the most important tools of disease control. In our study, novel subunit vaccines on the basis of an amino-terminal domain of SBV Gc of 234 amino acids ("Gc Amino") first were tested and selected using a lethal small animal challenge model and then the best performing formulations also were tested in cattle. We could show that neither E. coli expressed nor the reduced form of "Gc Amino" protected from SBV infection...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211527/depth-specific-fluctuations-of-gene-expression-and-protein-abundance-modulate-the-photophysiology-in-the-seagrass-posidonia-oceanica
#6
Gabriele Procaccini, Miriam Ruocco, Lázaro Marín-Guirao, Emanuela Dattolo, Christophe Brunet, Daniela D'Esposito, Chiara Lauritano, Silvia Mazzuca, Ilia Anna Serra, Letizia Bernardo, Amalia Piro, Sven Beer, Mats Björk, Martin Gullström, Pimchanok Buapet, Lina M Rasmusson, Paulo Felisberto, Sylvie Gobert, John W Runcie, João Silva, Irene Olivé, Monya M Costa, Isabel Barrote, Rui Santos
Here we present the results of a multiple organizational level analysis conceived to identify acclimative/adaptive strategies exhibited by the seagrass Posidonia oceanica to the daily fluctuations in the light environment, at contrasting depths. We assessed changes in photophysiological parameters, leaf respiration, pigments, and protein and mRNA expression levels. The results show that the diel oscillations of P. oceanica photophysiological and respiratory responses were related to transcripts and proteins expression of the genes involved in those processes and that there was a response asynchrony between shallow and deep plants probably caused by the strong differences in the light environment...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211051/antibiotic-use-associated-with-vte-and-its-implications-a-new-trigger-for-thromboprophylaxis-and-for-reclassification-of-some-unprovoked-to-provoked-vte-s
#7
EDITORIAL
Jürg H Beer
No abstract text is available yet for this article.
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28208290/biochip-spray-simplified-coupling-of-surface-plasmon-resonance-biosensing-and-mass-spectrometry
#8
Sweccha Joshi, Han Zuilhof, Teris A van Beek, Michel W F Nielen
A simplified coupling of surface plasmon resonance (SPR) immuno-biosensing with ambient ionization mass spectrometry (MS) was developed. It combines two orthogonal analysis techniques: the biosensing capability of SPR and the chemical identification power of high resolution MS. As a proof-of-principle, deoxynivalenol (DON), an important mycotoxin, was captured using an SPR gold chip containing an antifouling layer and monoclonal antibodies against the toxin and, after washing, the chip could be taken out and analyzed by direct spray MS of the biosensor chip to confirm the identity of DON...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28207686/notes-from-the-field-ongoing-cholera-epidemic-tanzania-2015-2016
#9
Rupa Narra, Justin M Maeda, Herilinda Temba, Janneth Mghamba, Ali Nyanga, Ashley L Greiner, Muhammad Bakari, Karlyn D Beer, Sae-Rom Chae, Kathryn G Curran, Rachel B Eidex, James J Gibson, Thomas Handzel, Stephen J Kiberiti, Rogath S Kishimba, Haji Lukupulo, Theophil Malibiche, Khalid Massa, Amani E Massay, Lindsey S McCrickard, Geofrey J Mchau, Vida Mmbaga, Ahmed A Mohamed, Elibariki R Mwakapeje, Emmanuel Nestory, Anna E Newton, Elvis Oyugi, Anu Rajasingham, Michelle E Roland, Neema Rusibamayila, Senga Sembuche, Loveness J Urio, Tiffany A Walker, Alice Wang, Robert E Quick
No abstract text is available yet for this article.
February 17, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28207070/giardiasis-diagnosis-and-treatment-practices-among-commercially-insured-persons-in-the-united-states
#10
Karlyn D Beer, Sarah A Collier, Fan Du, Julia W Gargano
No abstract text is available yet for this article.
February 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28204962/the-clinical-anatomy-of-the-insertion-of-the-rotator-cuff-tendons
#11
M Vosloo, N Keough, M A De Beer
The rotator cuff (RC) insertions according to most anatomical texts are described as being separate from one another. However, clear fusion of the RC tendon fibres exists with prior studies showing this interdigitation forming a common, continuous insertion onto and around the lesser and greater tubercles (LT and GT) of the humerus. Current surgical repair methods (especially arthroscopic techniques) rarely mention or consider these connections during repair and suture anchor implantation. The general principles of RC surgery remain a controversial subject, due to various available techniques, surgeon experience and preference, and the contradicting success rates...
February 16, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28199928/spectrophotometric-determination-of-meclizine-hydrochloride-and-pyridoxine-hydrochloride-in-laboratory-prepared-mixtures-and-in-their-pharmaceutical-preparation
#12
Maha M Ibrahim, Eman S Elzanfaly, Mohamed B El-Zeiny, Nesreen K Ramadan, Khadiga M Kelani
In this paper, three rapid, simple, accurate and precise spectrophotometric methods were developed for the determination of meclizine hydrochloride in the presence of pyridoxine hydrochloride without previous separation. The methods under study are dual wavelength (DWL), ratio difference (RD) and continuous wavelet transform (CWT). On the other hand, pyridoxine hydrochloride (PYH) was determined directly at 291nm. The methods obey Beer's law in the range of (5-50μg/mL) for both compounds. All the methods were validated according to the ICH guidelines where the accuracy was found to be 98...
February 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28199510/endothelial-lox-1-activation-differentially-regulates-arterial-thrombus-formation-depending-on-oxldl-levels-role-of-the-oct-1-sirt1-and-erk1-2-pathways
#13
Alexander Akhmedov, Giovanni G Camici, Martin F Reiner, Nicole Bonetti, Sarah Costantino, Erik W Holy, Remo D Spescha, Simona Stivala, Ariane Schaub Clerigué, Thimoteus Speer, Alexander Breitenstein, Jasmin Manz, Christine Lohmann, Francesco Paneni, Juerg-Hans Beer, Thomas F Lüscher
No abstract text is available yet for this article.
February 11, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28198625/curcumin-attenuates-n-nitrosodiethylamine-induced-liver-injury-in-mice-by-utilizing-the-method-of-metabonomics
#14
Peiyu Qiu, Jiachen Sun, Shuli Man, He Yang, Long Ma, Peng Yu, Wenyuan Gao
N-Nitrosodiethylamine (DEN) as one of food additives existed in cheddar cheese, processed meats, beer, water and so forth. It possessed a potent hepatocarcinogen in animals and humans. Curcumin as a natural dietary compound decreased DEN-induced hepatocarcinogenesis in this research. According to the histopathological examination macroof liver tissues, and biomarker detection in serum and livers, it demonstrated that curcumin attenuated DEN-induced hepatocarcinogenesis through parts of regulating the oxidant stress enzymes (T-SOD and CAT), liver function (ALT and AST) and LDHA, AFP level and COX-2/PGE2 pathway...
February 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28198463/overexpression-of-fam83h-as1-indicates-poor-patient-survival-and-knockdown-impairs-cell-proliferation-and-invasion-via-met-egfr-signaling-in-lung-cancer
#15
Jie Zhang, Shumei Feng, Wenmei Su, Shengbin Bai, Lei Xiao, Lihui Wang, Dafydd G Thomas, Jules Lin, Rishindra M Reddy, Philip W Carrott, William R Lynch, Andrew C Chang, David G Beer, You-Min Guo, Guoan Chen
Whole transcriptome analyses of next generation RNA sequencing (RNA-Seq) data from human cancer samples reveled thousands of uncharacterized non-coding RNAs including long non-coding RNA (lncRNA). Recent studies indicated that lncRNAs are emerging as crucial regulators in cancer processes and potentially useful as biomarkers for cancer diagnosis and prognosis. To delineate dysregulated lncRNAs in lung cancer, we analyzed RNA-Seq data from 461 lung adenocarcinomas (LUAD) and 156 normal lung tissues. FAM83H-AS1, one of the top dysregulated lncRNAs, was found to be overexpressed in tumors relative to normal lung and significantly associated with worse patient survival in LUAD...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28198089/a-comprehensive-proteome-map-of-glandular-trichomes-of-hop-humulus-lupulus-l-female-cones-identification-of-biosynthetic-pathways-of-the-major-terpenoid-related-compounds-and-possible-transport-proteins
#16
Antoine Champagne, Marc Boutry
Female flowers of hop (Humulus lupulus) are an essential source of terpenoid-related compounds, which are mainly used as flavoring in the beer brewing process. The compounds involved are bitter acids, terpenophenolics, as well as mono- and sesquiterpenoids. In this work, we analyzed the proteome of purified glandular trichomes (lupulin glands) from female flowers, which produce and accumulate these compounds. An extensive 2D-LC-MS/MS analysis identified 1,015 proteins. Of these, most correspond to housekeeping and primary metabolism-related proteins, albeit predominantly including amino acid and lipid metabolism, which feeds the specialized (secondary) metabolism...
February 15, 2017: Proteomics
https://www.readbyqxmd.com/read/28196787/current-forms-of-inhibitory-training-produce-no-greater-reduction-in-drinking-than-simple-assessment-a-preliminary-study
#17
Janette L Smith, Nicole J Dash, Stuart J Johnstone, Katrijn Houben, Matt Field
BACKGROUND: Disinhibition is apparent in users of many substances, including heavy drinkers. Previous research has shown that brief training to improve inhibitory control is associated with reduced alcohol consumption. We investigated whether a new form of inhibitory training would produce greater reductions, relative to a carefully designed control condition and a proven method of reducing consumption, the Brief Alcohol Intervention (BAI). METHODS: One hundred and fourteen regular drinkers were assigned randomly to one of five training conditions: Control (no inhibitory training); Beer-NoGo (inhibit responses linked to task-irrelevant pictures of beer); Restrained-Stop (requiring more urgent inhibition but without pictures of beer); Combined (a previously untested form of training requiring urgent inhibition to pictures of beer); or BAI...
January 31, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28196759/follow-up-mr-imaging-of-pi-rads-3-and-pi-rads-4-prostate-lesions
#18
Elke Hauth, Horst Jaeger, Horst Hohmuth, Meinrad Beer
OBJECTIVE: To determine the rate of malignancy after follow-up MR imaging of the prostate in PI-RADS 3 lesions without core biopsy and PI-RADS 4 lesions after negative initial core biopsy. MATERIALS AND METHODS: We performed follow-up MRI in 46/72 (64%) patients with PI-RADS 3 lesions and 26/72 (36%) patients with PI-RADS 4 lesions in baseline MRI. RESULTS: The rate of malignancy in PI-RADS 3 lesions was 4% (2/46) and in PI-RADS 4 lesions 69% (18/26)...
January 30, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28195956/group-based-trajectory-analysis-of-emotional-symptoms-among-survivors-after-severe-traumatic-brain-injury
#19
Dianxu Ren, Jun Fan, Ava M Puccio, David O Okonkwo, Sue R Beers, Yvette Conley
OBJECTIVES: Depressive symptoms and anxiety are fairly common emotional outcomes after severe traumatic brain injury (TBI). Life satisfaction is a main factor in the general construct of subjective well-being. However, there is limited literature available on the interrelationship between emotional outcomes and life satisfaction post-severe TBI over time. The purpose of this study was to characterize distinct patterns of change in depressive symptoms, anxiety, and life satisfaction over 24 months after severe TBI and evaluate the interrelationship of different trajectory groups among them as well as associated subject characteristics...
February 10, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28193355/a-paper-based-nanomodified-electrochemical-biosensor-for-ethanol-detection-in-beers
#20
Stefano Cinti, Mattia Basso, Danila Moscone, Fabiana Arduini
Herein, we report the first example of a paper-based screen-printed biosensor for the detection of ethanol in beer samples. Common office paper was adopted to fabricate the analytical device. The properties of this paper-based screen-printed electrode (SPE) were investigated by cyclic voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy, and they were compared with the well-established polyester-based SPEs as well. Paper demonstrated similar properties when compared with polyester, highlighting suitability towards its utilization in sensor development, with the advantages of low cost and simple disposal by incineration...
April 1, 2017: Analytica Chimica Acta
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