Michael A Giles, Crystal M Cooper, Manish K Jha, Cherise R Chin Fatt, Diego A Pizzagalli, Taryn L Mayes, Christian A Webb, Tracy L Greer, Amit Etkin, Joseph M Trombello, Henry W Chase, Mary L Phillips, Melvin G McInnis, Thomas Carmody, Phillip Adams, Ramin V Parsey, Patrick J McGrath, Myrna Weissman, Benji T Kurian, Maurizio Fava, Madhukar H Trivedi
The probabilistic reward task (PRT) has identified reward learning impairments in those with major depressive disorder (MDD), as well as anhedonia-specific reward learning impairments. However, attempts to validate the anhedonia-specific impairments have produced inconsistent findings. Thus, we seek to determine whether the Reward Behavior Disengagement (RBD), our proposed economic augmentation of PRT, differs between MDD participants and controls, and whether there is a level at which RBD is high enough for depressed participants to be considered objectively disengaged...
July 25, 2023: Behavioral Sciences