keyword
https://read.qxmd.com/read/38547099/etonogestrel-releasing-subdermal-contraceptive-implant-budget-impact-analysis-based-on-the-brazilian-private-healthcare-system
#1
JOURNAL ARTICLE
Agnaldo Lopes da Silva Filho, Ricardo Luis Pereira Bueno, Yohanna Ramires, Lara Marina Cruz Lino
High rates of unplanned pregnancies persist despite pharmacological developments and advancements in contraceptive methods. Here, we demonstrate that the etonogestrel-releasing subdermal contraceptive implant (IMP-ETN) may be an appropriate and cost-effective alternative to levonorgestrel-releasing intrauterine systems (LNG-IUSs) for women in Brazil. For our pharmacoeconomic analysis, we reviewed the literature on IMP-ETN regarding its acceptance, eligibility criteria, choice, relations with age, adverse events and, finally, the unmet need in the fee-for-service private healthcare sector...
2024: PloS One
https://read.qxmd.com/read/38546733/high-flow-humidified-oxygen-as-an-early-intervention-in-children-with-acute-severe-asthma-protocol-for-a-feasibility-randomized-controlled-trial
#2
JOURNAL ARTICLE
Hector Rojas-Anaya, Akshat Kapur, Graham Roberts, Damian Roland, Atul Gupta, Michaela Lazner, Jane Bayreuther, John Pappachan, Christina Jones, Stephen Bremner, Fleur Cantle, Paul Seddon
BACKGROUND: Acute severe asthma (ASA) is a leading cause of hospital attendance in children. Standard first-line therapy consists of high-dose inhaled bronchodilators plus oral corticosteroids. Treatment for children who fail to respond to first-line therapy is problematic: the use of intravenous agents is inconsistent, and side effects are frequent. High-flow humidified oxygen (HiFlo) is widely used in respiratory conditions and is increasingly being used in ASA, but with little evidence for its effectiveness...
March 28, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38545491/quantitative-measurement-of-hair-diameter-diversity-as-a-diagnostic-indicator-of-androgenetic-alopecia-in-korean-males-a-cross-sectional-study
#3
JOURNAL ARTICLE
Hee Ung Park, Kyung Bae Chung, Do-Young Kim
BACKGROUND: The conventional 20% threshold for hair diameter diversity (HDD), widely accepted for diagnosing androgenetic alopecia (AGA) in the vertex area, has not quantitatively analyzed. OBJECTIVE: To validate the HDD 20% threshold for AGA and develop a refined, Korean-specific criterion. METHODS: This study involved 240 male patients with AGA, categorized by the V stages of the basic and specific classification. Phototrichogram images of the vertex region were analyzed using Image J software for hair thickness measurement...
June 2024: JAAD international
https://read.qxmd.com/read/38545166/continuous-monitoring-of-body-temperature-for-objective-detection-of-health-and-safety-risks-in-construction-sites-an-analysis-of-the-accuracy-and-comfort-of-off-the-shelf-wearable-sensors
#4
JOURNAL ARTICLE
Farnad Nasirzadeh, Chandan Karmakar, Ahsan Habib, Kevin Benny Neelangal, Mostafa Mir, SangHyun Lee, Tony Arnel
Recent studies have shown the potential of wearable sensors for objective detection of health and safety risks in construction workers through their collected physiological data. Body temperature, as the focus of the current study, is one of the most important physiological parameters that can help to detect various health and safety risks such as heat stress, physical fatigue, and infectious diseases. This study aims to assess the applicability and performance of off-the-shelf wearable sensor devices to monitor workers' body temperature in construction sites by evaluating the accuracy of temperature measurements as well as the comfort of the devices...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38543408/evaluation-of-suitable-polymeric-matrix-carriers-during-loading-of-poorly-water-soluble-drugs-onto-mesoporous-silica-physical-stability-and-in-vitro-supersaturation
#5
JOURNAL ARTICLE
Afroditi Kapourani, Konstantinos Katopodis, Vasiliki Valkanioti, Melina Chatzitheodoridou, Christos Cholevas, Panagiotis Barmpalexis
The application of mesoporous carriers in formulations of amorphous solid dispersions (ASDs) has been suggested to enhance the stability of amorphous drugs. However, mesoporous carriers do not demonstrate satisfactory inhibitory effects on the precipitation of active pharmaceutical ingredients (APIs), and the inclusion of an appropriate polymer within ASDs becomes imperative to maintaining drug supersaturation. The aim of this study was to evaluate ternary olanzapine (OLN) ASDs with Syloid 244FP and to find an appropriate polymeric carrier...
March 13, 2024: Polymers
https://read.qxmd.com/read/38543201/influence-of-photosensitizer-on-photodynamic-therapy-for-peri-implantitis-a-systematic-review
#6
REVIEW
Thaís B M O Schweigert, João P R Afonso, Renata K da Palma, Iransé Oliveira-Silva, Carlos H M Silva, Elias Ilias Jirjos, Wilson Rodrigues Freitas Júnior, Giuseppe Insalaco, Orlando A Guedes, Luís V F Oliveira
The treatment of peri-implantitis is challenging in the clinical practice of implant dentistry. With limited therapeutic options and drug resistance, there is a need for alternative methods, such as photodynamic therapy (PDT), which is a minimally invasive procedure used to treat peri-implantitis. This study evaluated whether the type of photosensitizer used influences the results of inflammatory control, reduction in peri-implant pocket depth, bleeding during probing, and reduction in bone loss in the dental implant region...
February 22, 2024: Pharmaceutics
https://read.qxmd.com/read/38542867/comparative-pharmacokinetics-research-of-13-bioactive-components-of-jieyu-pills-in-control-and-attention-deficit-hyperactivity-disorder-model-rats-based-on-uplc-orbitrap-fusion-ms
#7
JOURNAL ARTICLE
Xuefang Liu, Yan Wan, Shuding Sun, Ting Wang, Ting Li, Qi Sun, Weiwei Zhang, Di Zhao, Yange Tian, Suxiang Feng
Jieyu Pills (JYPs), a Chinese medicine consisting of 10 herbal elements, have displayed promising clinical effectiveness and low by-effects in the treatment of depression. Prior investigations mostly focused on elucidating the mechanism and therapeutic efficacy of JYPs. In our earlier study, we provided an analysis of the chemical composition, serum pharmacochemistry, and concentrations of the main bioactive chemicals found in JYPs. However, our precise understanding of the pharmacokinetics and metabolism remained vague...
March 10, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542670/opposing-effects-of-nutritional-supply-on-bone-health-at-different-ages-based-on-the-national-health-and-nutrition-examination-survey-database
#8
JOURNAL ARTICLE
Jieqiong Wei, Yaxi Zhang, Yuehan Yuan, Min Li, Bingfang Zhai, Jihua Chen
(1) Background: Nutrients play an essential role in bone health, whether in achieving peak bone mineral density (BMD) or maintaining bone health. This study explores the relationship between nutrient supply and femoral bone health at different ages. (2) Methods: A total of 5603 participants meeting the inclusion and exclusion criteria were included in this study using the National Health and Nutrition Examination Survey (NHANES) database from 2005 to 2010, 2013 to 2014, and 2017 to 2018. Femoral bone mineral density and bone status were dependent variables, and dietary nutrient intake and nutrient intake status were independent variables...
March 7, 2024: Nutrients
https://read.qxmd.com/read/38542050/a-novel-method-for-determining-fibrin-fibrinogen-degradation-products-and-fibrinogen-threshold-criteria-via-artificial-intelligence-in-massive-hemorrhage-during-delivery-with-hematuria
#9
JOURNAL ARTICLE
Yasunari Miyagi, Katsuhiko Tada, Ichiro Yasuhi, Keisuke Tsumura, Yuka Maegawa, Norifumi Tanaka, Tomoya Mizunoe, Ikuko Emoto, Kazuhisa Maeda, Kosuke Kawakami, On Behalf Of The Collaborative Research In National Hospital Organization Network Pediatric And Perinatal Group
(1) Background: Although the diagnostic criteria for massive hemorrhage with organ dysfunction, such as disseminated intravascular coagulation associated with delivery, have been empirically established based on clinical findings, strict logic has yet to be used to establish numerical criteria. (2) Methods: A dataset of 107 deliveries with >2000 mL of blood loss, among 13,368 deliveries, was obtained from nine national perinatal centers in Japan between 2020 and 2023. Twenty-three patients had fibrinogen levels <170 mg/dL, which is the initiation of coagulation system failure, according to our previous reports...
March 21, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38542035/telehealth-in-informal-caregivers-of-stroke-survivors-a-systematic-review
#10
REVIEW
Juan Carlos Zuil-Escobar, Jose Antonio Martín-Urrialde, Juan Andrés Mesa-Jiménez, Rocío Palomo-Carrión, Carmen Belén Martínez-Cepa
Background : There has been an increase in people with disabilities who require continuous care, which often falls to informal carers (ICs). Stroke is one of the conditions where ICs are most needed. Therefore, it is necessary for ICs to improve their caregiving skills and self-care capacity. Telehealth (TH) can facilitate them. The aim of this systematic review is to summarize the evidence of the effects of interventions on ICs of stroke patients. Methods : The search was conducted in Pubmed, Scopus, Web of Science, CINALH, Psychology and Behavioral Sciences Collection, and APA PsycInfo...
March 21, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541939/evaluation-of-prehospital-undertriage-in-relation-to-trauma-team-activation-results-from-a-prospective-study-in-12-level-one-german-trauma-centers
#11
JOURNAL ARTICLE
Helena Düsing, Paul Hagebusch, Markus Baacke, Dan Bieler, Michael Caspers, Valentin Clemens, Matthias Fröhlich, Lisa Hackenberg, Renè Hartensuer, Sebastian Imach, Kai Oliver Jensen, Annette Keß, Christian Kleber, Fabian Laue, Rolf Lefering, Mindaugas Maslauskas, Gerrit Matthes, André Nohl, Orkun Özkurtul, Thomas Paffrath, Vera Pedersen, Tristan Pfläging, Kai Sprengel, Philipp Störmann, Heiko Trentzsch, Christian Waydhas, Uwe Schweigkofler, On Behalf Of The Nis-Trauma TAcTIC Study Group
Background/Objective: This prospective, multicenter observational cohort study was carried out in 12 trauma centers in Germany and Switzerland. Its purpose was to evaluate the rate of undertriage, as well as potential consequences, and relate these with different Trauma Team Activation Protocols (TTA-Protocols), as this has not been done before in Germany. Methods : Each trauma center collected the data during a three-month period between December 2019 and February 2021. All 12 participating hospitals are certified as supra-regional trauma centers...
March 16, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541153/development-of-a-new-bioequivalent-omeprazole-product
#12
JOURNAL ARTICLE
Gulzina Kumisbek, David Vetchý, Arshyn Kadyrbay
Background and Objectives: The enteric form of omeprazole is one of the most commonly prescribed medications. Similarly to Europe, Kazakhstan relies on the localization of pharmaceutical drug production as one of its primary strategies to ensure that its population has access to affordable and good-quality medicines. This study comprehensively describes the technologically available development of bioequivalent delayed-release omeprazole. Materials and Methods: Various regimes and technological parameters were tested on laboratory- and production-scale equipment to establish a technical process where a functional and gastro-protective layer is essential...
March 2, 2024: Medicina
https://read.qxmd.com/read/38541012/diplopia-in-movement-disorders-a-systematic-review-of-the-literature
#13
REVIEW
Larisa Ungureanu, Laura Irincu, Stefania Diaconu, Bianca Oprițoiu, K Ray Chaudhuri, Cristian Falup-Pecurariu
INTRODUCTION: Although the reported frequency of diplopia is between 10 to 40% of patients with Parkinson's disease (PD) and other movement disorders, it remains one of the most undiagnosed non-motor symptoms. Furthermore, it has a major impact on the quality of life of these patients. The aim of this study is to systematically review the literature regarding the frequency, causes, and implications of diplopia in movement disorders. METHODOLOGY: An electronic search was conducted in March and June 2023 using the PubMed database in order to identify appropriate studies...
February 29, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38539160/systems-for-rating-bodies-of-evidence-used-in-systematic-reviews-of-air-pollution-exposure-and-reproductive-and-children-s-health-a-methodological-survey
#14
JOURNAL ARTICLE
Sophie K F Michel, Aishwarya Atmakuri, Ondine S von Ehrenstein
BACKGROUND: Translating findings from systematic reviews assessing associations between environmental exposures and reproductive and children's health into policy recommendations requires valid and transparent evidence grading. METHODS: We aimed to evaluate systems for grading bodies of evidence used in systematic reviews of environmental exposures and reproductive/ children's health outcomes, by conducting a methodological survey of air pollution research, comprising a comprehensive search for and assessment of all relevant systematic reviews...
March 28, 2024: Environmental Health
https://read.qxmd.com/read/38538448/pharmaceutical-recommendations-for-therapeutic-appropriateness-in-multiple-sclerosis-patients
#15
JOURNAL ARTICLE
María Del Mar Sánchez Suárez, Alicia Martín Roldán, Maria Rosa Cantudo Cuenca, Alberto Jiménez Morales
OBJECTIVE: To determine the prevalence of PIMDINAC criteria and to implement pharmacological interventions in a population with multiple sclerosis over 55 years of age. METHODS: Retrospective observational open-label study including patients with multiple sclerosis aged 55 years and older between December 2022 and February 2023. The main variable determined was the percentage of compliance with the PIMDINAC criteria. RESULTS: Ninety-five patients were included, with the presence of PIMDINAC criteria detected in 67...
March 26, 2024: Farmacia Hospitalaria
https://read.qxmd.com/read/38537902/using-the-behaviour-change-wheel-to-identify-barriers-and-targeted-strategies-to-improve-adherence-in-randomised-clinical-trials-the-example-of-mel-self-trial-of-patient-led-surveillance-for-melanoma
#16
JOURNAL ARTICLE
Deonna M Ackermann, Jolyn K Hersch, Monika Janda, Karen Bracken, Robin M Turner, Katy J L Bell
BACKGROUND: Adherence to self-management interventions is critical in both clinical settings and trials to ensure maximal effectiveness. This study reports how the Behaviour Change Wheel may be used to assess barriers to self-management behaviours and develop strategies to maximise adherence in a trial setting (the MEL-SELF trial of patient-led melanoma surveillance). METHODS: The Behaviour Change Wheel was applied by (i) using the Capability, Opportunity, Motivation-Behaviour (COMB) model informed by empirical and review data to identify adherence barriers, (ii) mapping identified barriers to corresponding intervention functions, and (iii) identifying appropriate behaviour change techniques and developing potential solutions using the APEASE (Affordability, Practicability, Effectiveness and cost-effectiveness, Acceptability, Side-effects and safety, Equity) criteria...
March 25, 2024: Contemporary Clinical Trials
https://read.qxmd.com/read/38536490/symptoms-of-selective-mutism-beyond-failure-to-speak-in-children-and-adolescents
#17
JOURNAL ARTICLE
Felix Vogel, Carolin Röse, Christina Schwenck
Understanding the symptoms of a mental disorder is essential for accurate diagnosis or selecting appropriate treatment targets. Despite this, there is a surprising lack of systematic research on the symptoms of selective mutism (SM). While the DSM-5 defines failure to speak as the only core symptom of SM, sparse research suggests that children with SM may experience additional symptoms. Previous studies have been limited in their identification of symptoms of SM, either by using a predefined set of symptoms or by only asking for anxiety-specific symptoms...
March 27, 2024: European Child & Adolescent Psychiatry
https://read.qxmd.com/read/38536455/matching-proposed-clinical-and-mri-criteria-of-aggressive-multiple-sclerosis-to-serum-and-cerebrospinal-fluid-markers-of-neuroaxonal-and-glial-injury
#18
JOURNAL ARTICLE
Martin A Schaller-Paule, Michelle Maiworm, Jan Hendrik Schäfer, Lucie Friedauer, Elke Hattingen, Katharina Johanna Wenger, Frank Weber, Jasmin Jakob, Falk Steffen, Stefan Bittner, Yavor Yalachkov, Christian Foerch
BACKGROUND: Definitions of aggressive MS employ clinical and MR imaging criteria to identify highly active, rapidly progressing disease courses. However, the degree of overlap between clinical and radiological parameters and biochemical markers of CNS injury is not fully understood. Aim of this cross-sectional study was to match clinical and MR imaging hallmarks of aggressive MS to serum/CSF markers of neuroaxonal and astroglial injury (neurofilament light chain (sNfL, cNfL), and glial fibrillary acidic protein (sGFAP, cGFAP))...
March 27, 2024: Journal of Neurology
https://read.qxmd.com/read/38534940/the-development-and-testing-of-a-patient-decision-aid-for-individuals-with-homologous-recombinant-proficient-ovarian-cancer-who-are-considering-niraparib-maintenance-therapy
#19
JOURNAL ARTICLE
Laura Hopkins, Mark Carey, Linda Brown, Sabryna McCrea, Mark Milne, Dawne Tokaryk, Dawn Stacey
New treatments for ovarian cancer are available that require trade-offs between progression-free survival and quality of life. The aim of this study was to develop a decision aid for patients with homologous recombinant proficient (HRP) tumors, as the benefit-harm ratio of niraparib needs consideration. This decision aid was created with a systematic and iterative development process based on the Ottawa Decision Support Framework. The decision aid was user-tested for acceptability, usability, and comprehensibility using a survey completed by a sample of patients with ovarian cancer and oncologists...
March 8, 2024: Current Oncology
https://read.qxmd.com/read/38534720/antimicrobial-and-diagnostic-stewardship-of-the-novel-%C3%AE-lactam-%C3%AE-lactamase-inhibitors-for-infections-due-to-carbapenem-resistant-enterobacterales-species-and-pseudomonas-aeruginosa
#20
REVIEW
Stefanos Ferous, Cleo Anastassopoulou, Vassiliki Pitiriga, Georgia Vrioni, Athanasios Tsakris
Carbapenem-resistant Gram-negative bacterial infections are a major public health threat due to the limited therapeutic options available. The introduction of the new β-lactam/β-lactamase inhibitors (BL/BLIs) has, however, altered the treatment options for such pathogens. Thus, four new BL/BLI combinations-namely, ceftazidime/avibactam, meropenem/vaborbactam, imipenem/relebactam, and ceftolozane/tazobactam-have been approved for infections attributed to carbapenem-resistant Enterobacterales species and Pseudomonas aeruginosa ...
March 21, 2024: Antibiotics
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