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https://www.readbyqxmd.com/read/29785683/targeted-therapies-and-adverse-drug-reactions-in-oncology-the-role-of-clinical-pharmacist-in-pharmacovigilance
#1
G Fornasier, M Taborelli, S Francescon, J Polesel, M Aliberti, P De Paoli, P Baldo
Background The majority of adverse drug reactions (ADRs) reported in the summary of product characteristics (SPCs) are based on pivotal clinical trials, performed under controlled conditions and with selected patients. Objectives (1) to observe ADRs in the real-world setting and to evaluate if the supervision of the pharmacist impacts on the management of ADRs and on the satisfaction of patients; (2) to sensitise health professionals and patients on the need to increase the reporting of ADRs, in compliance with Pharmacovigilance...
May 21, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29785228/evaluating-the-utility-of-a-structured-clinical-protocol-for-reducing-the-impact-of-behavioural-and-psychological-symptoms-of-dementia-in-progressive-neurological-diseases-a-pilot-study
#2
Nicholas P Ryan, Laura Scott, Maryanne McPhee, Susan Mathers, Marie-Claire Davis, Roxanne Maule, Fiona Fisher
Objectives: Behavioural and psychological symptoms of dementia (BPSD) cause significant distress to both aged care residents and staff. Despite the high prevalence of BPSD in progressive neurological diseases (PNDs) such as multiple sclerosis, Huntington's disease, and Parkinson's disease, the utility of a structured clinical protocol for reducing BPSD has not been systematically evaluated in PND populations. Method: Staff ( n = 51) and individuals with a diagnosis of PND ( n = 13) were recruited into the study, which aimed to evaluate the efficacy of a PND-specific structured clinical protocol for reducing the impact of BPSD in residential aged care (RAC) and specialist disability accommodation (SDA) facilities...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/29785036/a-novel-microrna-signature-predicts-survival-in-liver-hepatocellular-carcinoma-after-hepatectomy
#3
Qiang Fu, Fan Yang, Tengxiao Xiang, Guoli Huai, Xingxing Yang, Liang Wei, Hongji Yang, Shaoping Deng
Liver hepatocellular carcinoma (LIHC) is the most common type of primary liver cancer. In the current study, genome-wide miRNA-Seq and mRNA profiles in 318 LIHC patients derived from The Cancer Genome Atlas (TCGA) were analysed to identify miRNA-based signatures for LIHC prognosis with survival analysis and a semi-supervised principal components (SPC) method. A seven-miRNA signature was confirmed for overall survival (OS) prediction by comparing miRNA profiles in paired primary tumour and solid tumour normal tissues...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29783904/opportunity-to-discuss-ethical-issues-during-clinical-learning-experience
#4
Alvisa Palese, Silvia Gonella, Anne Destrebecq, Irene Mansutti, Stefano Terzoni, Michela Morsanutto, Pietro Altini, Anita Bevilacqua, Anna Brugnolli, Federica Canzan, Adriana Dal Ponte, Laura De Biasio, Adriana Fascì, Silvia Grosso, Franco Mantovan, Oliva Marognolli, Raffaela Nicotera, Giulia Randon, Morena Tollini, Luisa Saiani, Luca Grassetti, Valerio Dimonte
BACKGROUND: Undergraduate nursing students have been documented to experience ethical distress during their clinical training and felt poorly supported in discussing the ethical issues they encountered. Research aims: This study was aimed at exploring nursing students' perceived opportunity to discuss ethical issues that emerged during their clinical learning experience and associated factors. RESEARCH DESIGN: An Italian national cross-sectional study design was performed in 2015-2016...
January 1, 2018: Nursing Ethics
https://www.readbyqxmd.com/read/29783238/clinical-efficiency-of-dynamic-observation-of-patients-with-epidermal-dysplasia-of-the-skin
#5
Oleg L Ziukov, Оlena O Oshyvalova
OBJECTIVE: Introduction: Non-melanoma skin cancer is the most common type of cancer among the population of Ukraine. The aim: The study of clinical efficacy of dynamic observation of patients with epidermal dysplasia of the skin. PATIENTS AND METHODS: Materials and methods: To study epidermal dysplasia of the skin there was used identifying information of patients, who were under dynamic observation of dermatologists of the State Scientific Institution "Research and Practical Centre of Preventive and Clinical Medicine" of the State Administration in 2013-2017...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783207/perspectives-for-applying-the-additional-study-methods-for-diagnostics-optimization-of-postoperative-hypertrophic-scars-of-the-head-and-neck
#6
David S Avetikov, Olha P Bukhanchenko, Ihor O Ivanytskyi, Viktoriia V Aipert, Dmytro V Steblovskyi
OBJECTIVE: Introduction: The issue of improving the quality of diagnosis, prevention and treatment of patients with pathological scarring of the head and neck is being actively developed throughout the world. The aim of the research is to improve diagnostics of hypertrophic scars of the head and neck through the establishment of structural features of scar-modified tissues using RGB-system and ultrasound examination. PATIENTS AND METHODS: Materials and methods: In this study, 60 patients with hypertrophic scars of the head and neck were examined...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782992/single-ultra-high-dose-cholecalciferol-to-prevent-vitamin-d-deficiency-in-pediatric-hematopoietic-stem-cell-transplantation
#7
Gregory Wallace, Sonata Jodele, Kasiani C Myers, Christopher E Dandoy, Javier El-Bietar, Adam Nelson, Ashley Teusink-Cross, Pooja Khandelwal, Cynthia Taggart, Catherine M Gordon, Stella M Davies, Jonathan C Howell
BACKGROUND: Vitamin D (vitD) deficiency is prevalent among childhood hematopoietic stem cell transplantation (HSCT) recipients and associated with inferior transplant survival at 100 days after transplantation. Achieving and maintaining therapeutic vitD levels in HSCT recipients is extremely challenging in the first 3-6 months after transplant due to poor compliance in the setting of mucositis, and concomitant use of critical transplant drugs that interfere with vitD absorption. We sought to evaluate the safety and efficacy of a single, ultra-high dose of vitD given prior to childhood HSCT to maintain levels in a therapeutic range during the peri-transplantation period...
May 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29782501/disentangling-the-complexity-of-tropical-small-scale-fisheries-dynamics-using-supervised-self-organizing-maps
#8
Manuel Mendoza-Carranza, Elisabet Ejarque, Leopold A J Nagelkerke
Tropical small-scale fisheries are typical for providing complex multivariate data, due to their diversity in fishing techniques and highly diverse species composition. In this paper we used for the first time a supervised Self-Organizing Map (xyf-SOM), to recognize and understand the internal heterogeneity of a tropical marine small-scale fishery, using as model the fishery fleet of San Pedro port, Tabasco, Mexico. We used multivariate data from commercial logbooks, including the following four factors: fish species (47), gear types (bottom longline, vertical line+shark longline and vertical line), season (cold, warm), and inter-annual variation (2007-2012)...
2018: PloS One
https://www.readbyqxmd.com/read/29782479/basic-training-a-pilot-study-of-balance-strengthening-exercises-in-heart-failure
#9
Rita McGuire, Julie Honaker, Bunny Pozehl, Melody Hertzog
PURPOSE: The aim of this pilot study was to evaluate the effect of a multicomponent balance and resistance training intervention on physical function, balance, and falls in older (≥65 years) community-dwelling heart failure (HF) patients. DESIGN: Randomized, two-group repeated-measures experimental design. METHODS: The intervention involved once weekly supervised group sessions with home sessions encouraged twice weekly. Focus groups held pre/post intervention...
May 19, 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29781981/national-patient-safety-program-in-brazil-incidents-reported-between-2014-and-2017
#10
Tássia Nery Faustino, Edenise Maria Santos da Silva Batalha, Silvana Lima Vieira, Andressa Garcia Nicole, Alexandre Souza Morais, Daisy Maria Rizatto Tronchin, Marta Maria Melleiro
OBJECTIVE: The aim of the study was to analyze the patient safety incidents reported to the Brazilian National Health Surveillance System from March 2014 to March 2017. METHOD: A documentary study that used the records of the incidents published in the Reports of Adverse Events (AE) in Brazil. The following variables were selected: number of incidents by type, type of health service, hospital unit, and degree of harm. To find whether there was a significant difference across the Brazilian regions by notifications related to general incidents, AE, and deaths, the analysis of variance and the Tukey tests were used...
May 16, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29781697/the-roles-training-and-knowledge-of-community-health-workers-about-diabetes-and-hypertension-in-khayelitsha-cape-town
#11
Lungiswa P Tsolekile, Helen Schneider, Thandi Puoane
BACKGROUND:  The current roles and capacity of community health workers (CHWs) in the management and control of non-communicable diseases (NCDs) remain poorly understood. OBJECTIVES:  To assess CHWs' current roles, training and knowledge about diabetes and hypertension in Khayelitsha, Cape Town. METHODS:  A cross-sectional study of 150 CHWs from two non-governmental organisations contracted to provide NCD care as part of a comprehensive package of services was conducted...
March 26, 2018: Curationis
https://www.readbyqxmd.com/read/29781696/barriers-to-tuberculosis-and-human-immunodeficiency-virus-treatment-guidelines-adherence-among-nurses-initiating-and-managing-anti-retroviral-therapy-in-kwazulu-natal-and-north-west-provinces
#12
Lufuno Makhado, Mashudu Davhana-Maselesele, Jason E Farley
BACKGROUND:  Nurses, as front-line care providers in the South Africa's health care system, are called upon to deliver integrated interventions for tuberculosis and human immunodeficiency virus (TB and HIV) including nurse-initiated management of anti-retroviral therapy (NIMART) and anti-TB treatment. Adherence to treatment guidelines and factors associated with non-adherence to treatment guidelines among nurses remain under explored. PURPOSE:  To explore and describe barriers to treatment guidelines adherence among nurses initiating and managing anti-retroviral therapy and anti-TB treatment in KwaZulu-Natal and North West provinces...
March 26, 2018: Curationis
https://www.readbyqxmd.com/read/29781596/conservative-treatment-of-rotator-cuff-tear-in-older-patients-a-role-for-the-cycloergometer-a-randomized-study
#13
Bernardo Gialanella, Laura Comini, Marta Gaiani, Adriana Olivares, Simonetta Scalvini
BACKGROUND: To date, there are no published data on the use of devices in the management of rotator cuff tear (RCT). AIM: To evaluate the effect of supervised arm cycloergometer training on pain during activities and shoulder functionality in patients with symptomatic full-thickness RCT. DESIGN: This is a prospective randomized controlled pilot study. SETTING: Outpatients of our Rehabilitation Unit. POPULATION: In this pilot study, 40 elderly outpatients (>70 years) with RCT were randomized to two groups: Cycloergometer (CYC) vs...
May 18, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29780889/how-to-conceptualize-and-implement-a-phd-program-in-health-sciences-the-basel-approach
#14
Franziska Keller, Suzanne Dhaini, Matthias Briel, Sina Henrichs, Christoph Höchsmann, Daniel Kalbermatten, Nino Künzli, Annette Mollet, Christian Puelacher, Arno Schmidt-Trucksäss, Belinda von Niederhäusern, Sabina De Geest
Objectives: Over the past decade, several excellent guidelines have been published on how to enhance the quality of PhD education in Europe. Aimed primarily at preparing students for innovative roles in their fields, they include variously structured approaches to curricular offerings, as well as other program components applicable across specialties (eg: supervisor support, scientific conduct, transferable skills). Since 2012, the interdisciplinary PhD Program in Health Sciences (PPHS) at the Faculty of Medicine of the University of Basel in Switzerland has focused on translating these guidelines into a 21st-century health sciences PhD program...
January 2018: Journal of Medical Education and Curricular Development
https://www.readbyqxmd.com/read/29780731/the-resident-s-point-of-view-in-the-learning-curve-of-thymic-mis-why-should-i-learn-it
#15
REVIEW
Anna E Frick, Hans Van Veer, Herbert Decaluwé, Willy Coosemans, Dirk Van Raemdonck
Minimally invasive surgery (MIS) in thoracic surgery became quite popular during the last years. The aim of introducing and performing more MIS is to reduce surgical trauma, pain and complications in patients. Training in MIS increases operative time and thus cost in theatre but thus improves with experience. For a resident, the cases should be well selected with experienced supervision in a suitable setting with supporting staff and optimal instruments. Understanding the anatomy of the lung, using simulators, and attending workshops makes the learning curve shorter...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29780317/one-channel-surface-electromyography-decomposition-for-muscle-force-estimation
#16
Wentao Sun, Jinying Zhu, Yinlai Jiang, Hiroshi Yokoi, Qiang Huang
Estimating muscle force by surface electromyography (sEMG) is a non-invasive and flexible way to diagnose biomechanical diseases and control assistive devices such as prosthetic hands. To estimate muscle force using sEMG, a supervised method is commonly adopted. This requires simultaneous recording of sEMG signals and muscle force measured by additional devices to tune the variables involved. However, recording the muscle force of the lost limb of an amputee is challenging, and the supervised method has limitations in this regard...
2018: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/29779552/using-echo-clinics-to-promote-capacity-building-in-clinical-supervision
#17
Michael J Chaple, Thomas E Freese, Beth A Rutkowski, Laurie Krom, Andrew S Kurtz, James A Peck, Paul Warren, Susan Garrett
INTRODUCTION: Project Extension for Community Healthcare Outcomes (ECHO™) is a hub-and-spoke knowledge-sharing network, led by expert teams who use multipoint videoconferencing to conduct virtual clinics with community providers in order to improve the quality of care. For this project, members of the Addiction Technology Transfer Center network applied this model in order to enhance workforce capacity to deliver clinical supervision for the treatment of substance use disorders. METHODS: Clinical supervisors (n=66) employed in substance use disorder treatment programs were recruited to participate in this pilot study...
June 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29779548/utilization-and-economic-contribution-of-psychiatric-mental-health-nurse-practitioners-in-public-behavioral-health-services
#18
Susan A Chapman, Bethany J Phoenix, Talia E Hahn, Deborah C Strod
INTRODUCTION: Expanded insurance coverage through the Affordable Care Act and parity in behavioral health coverage have increased demand for services. Yet there is a persistent shortage in the behavioral health workforce. Psychiatric Mental Health Nurse Practitioners (PMHNPs) may be part of the solution to shortages but are not yet fully utilized. The purpose of this study was to describe how PMHNPs are utilized, identify barriers to full utilization, and assess PMHNPs' economic contribution in public behavioral health systems...
June 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29779546/state-legislative-approach-to-enumerating-behavioral-health-workforce-shortages-lessons-learned-in-new-mexico
#19
Deborah B Altschul, Caroline A Bonham, Martha J Faulkner, Amy W Farnbach Pearson, Jessica Reno, Wayne Lindstrom, Shelley M Alonso-Marsden, Annette Crisanti, Julie G Salvador, Richard Larson
Nationally, the behavioral health workforce is in crisis because of a lack of resources, culturally responsive services, quality clinical supervision, sufficient training in evidence-based practices, and targeted recruitment and retention. Disparities in access to behavioral health care are particularly significant in New Mexico, where 25% of the population live in rural areas, and behavioral health shortages are among the highest in the nation. Additionally, as a Medicaid expansion state, New Mexico providers experience increased demand for services at a time when the state is challenged with limited workforce capacity...
June 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29778819/detection-of-tem-and-ctx-m-genes-from-ciprofloxacin-resistant-proteus-mirabilis-and-escherichia-coli-isolated-on-urinary-tract-infections-utis
#20
Govindan Rajivgandhi, Muthuchamy Maruthupandy, Natesan Manoharan
The multidrug resistant Gram negative bacteria (MDRGNB) is an emerging burden and now represents a daily challenge for the management of antimicrobial therapy in healthcare settings. The present study was aimed to detect the prevalence of TEM and CTX-M type genes from GNB on urinary tract infection (UTIs). The ciprofloxacin resistant uropathogens were detected by HEXA UTI 5 disc diffusion method. The phenotypic detection of uropathogens producing extended spectrum beta lactamases (ESBLs) was confirmed by double disc combination (DDCT) and phenotype confirmation methods (PCT)...
May 17, 2018: Microbial Pathogenesis
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