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neutrophil lymphocyte ratio

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https://www.readbyqxmd.com/read/29230007/elevated-preoperative-neutrophil-lymphocyte-ratio-predicts-upgrading-at-radical-prostatectomy
#1
Mehmet Özsoy, Marco Moschini, Harun Fajkovic, Francesco Soria, Christian Seitz, Tobias Klatte, Kilian Gust, Alberto Briganti, Pierre I Karakiewicz, Morgan Roupret, Gero Kramer, Shahrokh F Shariat
BACKGROUND: Neutrophil-lymphocyte ratio (NLR) is a widely used, representative marker of systemic inflammatory response within the body. NLR can be calculated from simple, inexpensive peripheral blood samples. High NLR is a negative prognostic factor in a variety of malignancies including urological tumors. In this study, we aim to assess the prognostic value of preoperative neutrophil- lymphocyte ratio (NLR) in patients treated with radical prostatectomy (RP) for localized prostate cancer (PCa)...
December 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29228679/prognostic-value-of-the-c-reactive-protein-albumin-ratio-car-in-patients-with-operable-soft-tissue-sarcoma
#2
Yao Liang, Wei Xiao, Yuan-Xiang Guan, Wei Wang, Huo Ying Chen, Cheng Fang, Xing Zhang, Zhi-Wei Zhou
Background: The preoperative C-reactive protein/Albumin ratio (CAR) is valuable for predicting the prognosis of patients with various types of cancers. The aim of the present study is to investigate the prognostic value of the preoperative CAR and compare it with other systemic inflammatory response markers in patients with soft tissue sarcoma (STS). Methods: This retrospective study included 206 patients with STS. The optimal cutoff value of the CAR was determined by receiver operating characteristic (ROC) analysis...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227818/neutrophil-lymphocyte-ratio-kinetics-in-patients-with-advanced-solid-tumours-on-phase-i-trials-of-pd-1-pd-l1-inhibitors
#3
Malaka Ameratunga, Maxime Chénard-Poirier, Irene Moreno Candilejo, Manuel Pedregal, Andrew Lui, David Dolling, Caterina Aversa, Alvaro Ingles Garces, Joo Ern Ang, Udai Banerji, Stan Kaye, Hui Gan, Bernard Doger, Victor Moreno, Johann de Bono, Juanita Lopez
BACKGROUND: Although the neutrophil-lymphocyte ratio (NLR) is prognostic in many oncological settings, its significance in the immunotherapy era is unknown. Mechanistically, PD-1/PD-L1 inhibitors may alter NLR. We sought to characterise NLR kinetics in patients with advanced solid tumours treated with PD-1/PD-L1 inhibitors. METHODS: Electronic records of patients treated with PD-1/PD-L1 inhibitors on phase I trials across three sites were reviewed. A high NLR (hNLR) was predefined as >5...
December 8, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29226641/modified-complete-blood-count-indices-as-predicting-markers-of-preeclampsia-from-gestational-hypertension-neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-and
#4
You La Jeon, Woo-In Lee, So Young Kang, Myeong Hee Kim
BACKGROUND: To evaluate modified complete blood count (CBC) indices as a predicting marker of preeclampsia (PE) from gestational hypertension (GH), we analyzed the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and platelet to neutrophil ratio (PNR). PNR was a newly designed index in this study based on results of PE patients having a tendency toward higher neutrophil count and lower platelet count compared to normal pregnant women in previous studies. METHODS: We recruited 86 normal pregnant women, 33 patients with GH and 68 patients with PE...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29225479/density-of-cd8-lymphocytes-in-biopsy-samples-combined-with-the-circulating-lymphocyte-ratio-predicts-pathologic-complete-response-to-chemoradiotherapy-for-rectal-cancer
#5
Binyi Xiao, Jianhong Peng, Rongxin Zhang, Jing Xu, Yongchun Wang, Yujing Fang, Junzhong Lin, Zhizhong Pan, Xiaojun Wu
Objectives: The systemic status and local immune status, as determined by the neutrophil-lymphocyte ratio (NLR) or the lymphocyte ratio (LYMR) and tumor-infiltrating lymphocyte (TIL) count, respectively, have been suggested as predictors of the tumor response to neoadjuvant chemoradiotherapy (nCRT) in rectal cancer, although the utility of these measures remains controversial. We aimed to investigate the values of the LYMR, NLR and TIL count and their combinations (TIL-LYMR/TIL-NLR) in predicting pathologic complete response (pCR) after nCRT...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29223800/total-and-differential-white-blood-cell-counts-and-hemodynamic-parameters-in-first-episode-psychosis
#6
Grant Moody, Brian J Miller
There is evidence for blood inflammatory abnormalities in patients with first-episode psychosis (FEP). The monocyte- and neutrophil-to-lymphocyte ratios (MLR; NLR) are markers of inflammation and endothelial dysfunction, and predictors of cardiovascular disease, the leading cause of death in schizophrenia. We investigated relationships between white blood cell (WBC) counts and hemodynamic parameters associated with cardiovascular disease risk in 25 subjects age 18-50 hospitalized for FEP and 44 controls. Subjects had a blood draw, vital signs, and medical history...
December 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29223125/tgf-%C3%AE-and-inflammatory-blood-markers-in-prediction-of-intraperitoneal-adhesions
#7
Kamil Torres, Łukasz Pietrzyk, Zbigniew Plewa, Karolina Załuska-Patel, Mariusz Majewski, Elżbieta Radzikowska, Anna Torres
PURPOSE: Intraperitoneal adhesions (IA) develop as a consequence of the healing process in peritoneum injured during surgeries. IA might be formed after all types of surgical interventions regardless the surgical approach with a higher incidence in obese individuals. Here we determine the diagnostic power of TGF-β and blood inflammatory parameters in the prediction of IA in obese patients undergoing second surgical intervention. MATERIALS AND METHODS: Eighty patients were divided into groups according to body mass index (BMI) values and presence of intraperitoneal adhesions (IA)...
December 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29221789/pretherapy-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-do-not-predict-survival-in-resectable-pancreatic-cancer
#8
Akhil Chawla, Tiffany L Huang, Andrew M Ibrahim, Jeffrey M Hardacre, Christopher Siegel, John B Ammori
BACKGROUND: Pretherapy serum neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have both been identified as prognostic in pancreatic ductal adenocarcinoma (PDAC). The aim of this study was to identify the prognostic implication of pretherapy NLR and PLR in patients with resectable PDAC. METHODS: Data were collected retrospectively on patients operated at our institution between 2004 and 2014. A Cox proportional hazards model was used to investigate the relationship between clinical and pathological parameters, NLR and PLR to overall survival (OS)...
December 5, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29221287/anti-cancer-activity-of-dose-fractioned-mpe-bevacizumab-regimen-is-paralleled-by-immune-modulation-in-advanced-squamous-nslc-patients
#9
Pierpaolo Pastina, Valerio Nardone, Stefania Croci, Giuseppe Battaglia, Francesca Vanni, Cristiana Bellan, Marcella Barbarino, Veronica Ricci, Susan Costantini, Francesca Capone, Cirino Botta, Mayra Rachele Zarone, Gabriella Misso, Mariarosaria Boccellino, Michele Caraglia, Antonio Giordano, Piero Paladini, Pierfrancesco Tassone, Pierosandro Tagliaferri, Maria Grazia Cusi, Luigi Pirtoli, Pierpaolo Correale
Background: Results from the BEVA2007 trial, suggest that the metronomic chemotherapy regimen with dose-fractioned cisplatin and oral etoposide (mPE) +/- bevacizumab, a monoclonal antibody to the vascular endothelial growth factor (VEGF), shows anti-angiogenic and immunological effects and is a safe and active treatment for metastatic non-small cell lung cancer (mNSCLC) patients. We carried out a retrospective analysis aimed to evaluate the antitumor effects of this treatment in a subset of patients with squamous histology...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221186/inflammatory-biomarkers-in-metastatic-colorectal-cancer-prognostic-and-predictive-role-beyond-the-first-line-setting
#10
Jakob Michael Riedl, Florian Posch, Florian Moik, Angelika Bezan, Joanna Szkandera, Maria Anna Smolle, Anne-Katrin Kasparek, Martin Pichler, Herbert Stöger, Michael Stotz, Armin Gerger
Introduction: Inflammatory biomarkers are useful prognostic tools in cancer patients. However, the prognostic and predictive value of inflammatory biomarkers beyond the 1st-line setting in metastatic colorectal cancer (mCRC) is unclear. Results: In multivariate analysis 1 standard deviation increase in neutrophil-lymphocyte-ratio (NLR) was associated with an 8.5% absolute lower objective-response-rate (ORR) in 1st-line (p<0.0001), 3% lower ORR in 2nd-line (p< 0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29219889/the-value-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-for-detecting-early-onset-neonatal-sepsis
#11
Emrah Can, Şahin Hamilcikan, Ceren Can
OBJECTIVE: The purpose of this study was to investigate the relationship between neonate early-onset sepsis (EOS) and the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) of term neonates. MATERIALS AND METHODS: This prospective observational study was conducted with term neonates diagnosed with EOS compared with 44 healthy controls. Exclusion criteria were prematurity, postmaturity, small or large for gestational age according to week of pregnancy, preeclampsia, gestational diabetes mellitus, chorioamnionitis, congenital major anomalies, and cyanotic congenital heart disease...
December 6, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29218020/peripheral-immune-alterations-in-major-depression-the-role-of-subtypes-and-pathogenetic-characteristics
#12
Frank Euteneuer, Katharina Dannehl, Adriana Del Rey, Harald Engler, Manfred Schedlowski, Winfried Rief
Depression has been associated with peripheral inflammatory processes and alterations in cellular immunity. Growing evidence suggests that immunological alterations may neither be necessary nor sufficient to induce depression in general, but seem to be associated with specific features. Using baseline data from the Outcome of Psychological Interventions in Depression trial, this exploratory study examines associations between depression subtypes and pathogenetic characteristics (i.e., melancholic vs non-melancholic depression, chronic vs non-chronic depression, age of onset, cognitive-affective and somatic symptom dimensions) with plasma levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, and numbers of leukocyte subpopulations in 98 patients with major depression (MD) and 30 age and sex-matched controls...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29216687/editorial-comment-to-high-neutrophil-to-lymphocyte-ratio-predicts-worse-overall-survival-in-patients-with-advanced-metastatic-urothelial-bladder-cancer
#13
Yoshio Ohno
No abstract text is available yet for this article.
December 7, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29215037/pre-treatment-inflammatory-indexes-as-predictors-of-survival-and-cetuximab-efficacy-in-metastatic-colorectal-cancer-patients-with-wild-type-ras
#14
Jing Yang, Xinli Guo, Manni Wang, Xuelei Ma, Xiaoyang Ye, Panpan Lin
This study aims at evaluating the prognostic significance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation indexes (SII) in metastatic colorectal cancer (mCRC) patients treated with cetuximab. Ninety-five patients receiving cetuximab for mCRC were categorized into the high or low NLR, PLR, LMR, and SII groups based on their median index values. Univariate and multivariate survival analysis were performed to identify the indexes' correlation with progression-free survival (PFS) and overall survival (OS)...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212235/ager-rs2070600-polymorphism-elevates-neutrophil-lymphocyte-ratio-and-mortality-in-metastatic-lung-adenocarcinoma
#15
Kakuhiro Yamaguchi, Hiroshi Iwamoto, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Background: The receptor for advanced glycation end-product (RAGE) is a multi-ligand receptor involved in inflammation. In the gene encoding RAGE (AGER), there are three well-known polymorphisms; rs2070600, rs1800624, and rs1800625, which potentially increase the risk of lung cancer. Remarkably, AGER rs2070600 polymorphism, which increases ligand-binding affinity, is a potential prognostic factor in non-small cell lung cancer, but the underlying mechanism is unclear. The neutrophil-lymphocyte ratio (NLR) reflects tumor-associated systemic inflammatory conditions; high ratios are associated with poor prognosis in multiple cancers...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212188/baseline-platelet-parameters-for-predicting-early-platelet-response-and-clinical-outcomes-in-patients-with-non-cardioembolic-ischemic-stroke-treated-with-clopidogrel
#16
Wenxian Li, Xiaomei Xie, Di Wei, Shijun Zhang, Yuanling Wu, Xuejun Fu, Zhen Jing, Weibiao Lu, Xinqiang Lai, Li'an Huang
Purpose: The present study investigated whether routine baseline platelet parameters(BPPs) detected before clopidogrel therapy in acute non-cardioembolic ischemic stroke(NCIS) could predict early platelet response and future clinical outcomes. Results: The CYP2C19 polymorphisms constituted independent risk factors for LCR. The number of female patients, the incidence of diabetes mellitus (DM), the level of low-density lipoprotein(LDL) cholesterol, and the neutrophil-to-lymphocyte ratio(NLR) were significantly high in the clinical clopidogrel resistance (CCR) group...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211406/can-preoperative-neutrophil-lymphocyte-ratio-predict-malignancy-in-patients-undergoing-partial-nephrectomy-because-of-renal-mass
#17
Sacit Nuri Gorgel, Kutan Ozer, Osman Kose, Ahmet Selçuk Dindar
PURPOSE: To evaluate the importance of preoperative neutrophil lymphocyte ratio (NLR) predicting malignancy in patients who undergo partial nephrectomy due to renal mass. MATERIALS AND METHODS: Seventy nine patients who underwent open partial nephrectomy for renal masses were included in this retrospective study. In preoperative routine blood tests, renal ultrasonography and contrast-enhanced computed tomography were performed for all patients. Preoperative neutrophil lymphocyte ratio were compared in patients with clear cell renal cell carcinoma (Group1, 65 patients) and benign lesions (Group 2, 14 patients)...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29209887/the-relationship-between-hematological-parameters-and-prognosis-of-children-with-acute-ischemic-stroke
#18
Ebru Yilmaz, Ayse Bayram Kacar, Adil Bozpolat, Gokmen Zararsiz, Burcu S Gorkem, Musa Karakukcu, Turkan Patiroglu, Hakan Gumus, Mehmet Akif Ozdemir, Alper Ozcan, Huseyin Per, Ekrem Unal
BACKGROUND: Stroke is rarely seen in children, but it is a major cause of morbidity and mortality. Therefore, there is a need for inexpensive and noninvasive diagnostic methods for estimating the prognosis. Although the prognostic importance of hematological parameters in acute ischemic stroke were reported in adult studies, there is a lack in pediatric ages. The aim of the study is to investigate the relationship between hematological parameters and prognosis of acute ischemic stroke in children...
December 5, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29209116/gastric-xanthelasma-and-metabolic-disorders-a-large-retrospective-study-among-chinese-population
#19
Yi Chen, Xin-Jue He, Min-Jian Zhou, You-Ming Li
AIM: To gain knowledge of xanthelasma, a large population-based study was conducted. METHODS: Patients who underwent upper gastrointestinal endoscopy at the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China during Jan 2009 to Nov 2016 were included. General characteristics as well as clinical data were collected, including blood routine, serum biochemical analysis, endoscopic findinds, histological evaluation and comorbiditie. Statistical analyses was performed using SPSS 20...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29207617/phenotypic-and-clinical-characterization-of-low-density-neutrophils-in-patients-with-advanced-lung-adenocarcinoma
#20
Yangyang Liu, Yue Hu, Feifei Gu, Jinyan Liang, Yulan Zeng, Xiaohua Hong, Kai Zhang, Li Liu
Purpose: An immunosuppressive subgroup of neutrophils, low density neutrophils (LDNs) was reported to be closely related to several diseases. This study was designed to explore the association between LDNs and advanced lung adenocarcinoma, as well as potential mechanisms. Results: The expression levels of surface CD molecules on LDNs were different from high density neutrophils (HDNs), consistent with previous studies. The ratio of LDNs/HDNs, rather than the percentage of LDNs in peripheral blood mononuclear cells (PBMCs), was significantly higher in lung adenocarcinoma patients than healthy controls...
October 31, 2017: Oncotarget
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