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neutrophil lymphocyte ratio

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https://www.readbyqxmd.com/read/29471252/relationship-between-monocytes-to-lymphocytes-ratio-and-axial-spondyloarthritis
#1
Yukai Huang, Weiming Deng, Shaoling Zheng, Fan Feng, Zhixiang Huang, Qidang Huang, Xin Guo, Zhengping Huang, Xuechang Huang, Xia Pan, Tianwang Li
BACKGROUND: Axial spondyloarthritis (axSpA) is a progressive, chronic, inflammatory skeletal disorder affecting the spine and sacroiliac joints. Many studies have shown that neutrophils, lymphocytes, monocytes, platelets, and red blood cells (RBCs) play important roles in the inflammatory process of axSpA. Neutrophils to lymphocytes ratio (NLR) and red blood cell distribution width (RDW) have been reported to be simple and inexpensive markers to indicate the disease activity of axSpA...
February 19, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29468834/peripheral-blood-clinical-laboratory-variables-associated-with-outcomes-following-combination-nivolumab-and-ipilimumab-immunotherapy-in-melanoma
#2
Samuel Rosner, Erica Kwong, Alexander N Shoushtari, Claire F Friedman, Allison S Betof, Mary Sue Brady, Daniel G Coit, Margaret K Callahan, Jedd D Wolchok, Paul B Chapman, Katherine S Panageas, Michael A Postow
Both the combination of nivolumab + ipilimumab and single-agent anti-PD-1 immunotherapy have demonstrated survival benefit for patients with advanced melanoma. As the combination has a high rate of serious side effects, further analyses in randomized trials of combination versus anti-PD-1 immunotherapy are needed to understand who benefits most from the combination. Clinical laboratory values that were routinely collected in randomized studies may provide information on the relative benefit of combination immunotherapy...
February 22, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29468284/is-neutrophil-to-lymphocytes-ratio-a-clinical-relevant-preoperative-biomarker-in-upper-tract-urothelial-carcinoma-a-meta-analysis-of-4385-patients
#3
REVIEW
Mihai Dorin Vartolomei, Shoji Kimura, Matteo Ferro, Liliana Vartolomei, Beat Foerster, Mohammad Abufaraj, Shahrokh F Shariat
BACKGROUND: Preoperative blood-based inflammatory biomarkers have been suggested to improve staging and prognostication in patients with upper-tract urothelial carcinoma (UTUC). Neutrophil-to-lymphocyte ratio (NLR) is the most studied blood-based biomarker. NLR is an indicator of systemic inflammation and has been shown to be associated with a poor prognosis in various malignancies. The aim of this study was to analyze the current evidence regarding the prognostic significance of preoperative NLR in patients undergoing radical nephroureterectomy (RNU) for UTUC to assess its prognostic potential...
February 21, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29467910/predictive-value-of-inflammatory-indexes-on-the-chemotherapeutic-response-in-patients-with-unresectable-lung-cancer-a-retrospective-study
#4
Haifeng Sun, Pingping Hu, Jiajun Du, Xinying Wang
Chemotherapy is widely administered to patients with advanced lung cancer; however, data regarding chemotherapeutic sensitivity are limited. The present study aimed to investigate the predictive value of inflammatory indexes for chemotherapeutic efficacy in advanced lung cancer. Patients with stage III and IV unresectable lung cancer that were treated with first-line chemotherapy between January 2007 and December 2011 were retrospectively identified, and chemotherapeutic response was evaluated following 2 or 3 chemotherapy cycles...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29466970/a-novel-combined-systemic-inflammation-based-score-can-predict-survival-of-intermediate-to-advanced-hepatocellular-carcinoma-patients-undergoing-transarterial-chemoembolization
#5
Chang Liu, Lei Li, Wu-Sheng Lu, Hua Du, Lu-Nan Yan, Tian-Fu Wen, Wu-Ran Wei, Li Jiang, Ming-Qing Xu
BACKGROUND: There is currently limited information regarding the prognostic ability of the dNLR-PNI (the combination of the derived neutrophil-to-lymphocyte ratio [dNLR] and prognostic nutritional index [PNI]) for hepatocellular carcinoma (HCC). This study aimed to assess the predictive ability of the dNLR-PNI in patients with intermediate-to-advanced HCC after transarterial chemoembolization (TACE). METHODS: A total of 761 HCC patients were enrolled in the study...
February 21, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29464075/interleukin-8-activity-influences-the-efficacy-of-adenoviral-oncolytic-immunotherapy-in-cancer-patients
#6
Kristian Taipale, Siri Tähtinen, Riikka Havunen, Anniina Koski, Ilkka Liikanen, Päivi Pakarinen, Riitta Koivisto-Korander, Matti Kankainen, Timo Joensuu, Anna Kanerva, Akseli Hemminki
After the landmark approval of T-VEC, oncolytic viruses are finding their way to the clinics. However, response rates have still room for improvement, and unfortunately there are currently no available markers to predict responses for oncolytic immunotherapy. Interleukin 8 (IL-8) production is upregulated in many cancers and it also connects to several pathways that have been shown to impair the efficacy of adenoviral immunotherapy. We studied the role of IL-8 in 103 cancer patients treated with oncolytic adenoviruses...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29462132/development-of-a-prognostic-scoring-system-for-patients-with-advanced-cancer-enrolled-in-immune-checkpoint-inhibitor-phase-1-clinical-trials
#7
Shiraj Sen, Kenneth Hess, David S Hong, Aung Naing, Sarina Piha-Paul, Filip Janku, Siqing Fu, Ishwaria M Subbiah, Holly Liu, Rahil Khanji, Le Huang, Shhyam Moorthy, Daniel D Karp, Apostolia Tsimberidou, Funda Meric-Bernstam, Vivek Subbiah
BACKGROUND: We sought to develop a prognostic scoring system to aid in patient selection for immune checkpoint inhibitor (ICI) phase 1 clinical trials. METHODS: Clinical data from patients treated in phase 1 ICI clinical trials at MD Anderson (MDA) Center were analysed. Seventeen clinical factors were studied. Recursive partitioning analysis, a tree-based model, was used to develop a regression tree and identify optimal cut-points based on differences in survival for each clinical factor...
February 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29457215/the-effect-of-anaesthetic-technique-during-primary-breast-cancer-surgery-on-neutrophil-lymphocyte-ratio-platelet-lymphocyte-ratio-and-return-to-intended-oncological-therapy
#8
A Ní Eochagáin, D Burns, B Riedel, D I Sessler, D J Buggy
Inflammation and immunosuppression contribute to the pathogenesis of cancer. An increased neutrophil-lymphocyte ratio reflects these processes and is associated with adverse cancer outcomes. Whether anaesthetic technique for breast cancer surgery influences these factors, and potentially cancer recurrence, remains unknown. We conducted a secondary analysis in patients enrolled in an ongoing trial of anaesthetic technique on breast cancer recurrence. The primary hypothesis was that postoperative neutrophil-lymphocyte ratio is lower in patients allocated to receive propofol-paravertebral rather than inhalational agent-opioid anaesthesia for primary breast cancer surgery...
February 19, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29455548/the-effects-of-smoking-on-neutrophil-lymphocyte-platelet-lymphocyte-ratios
#9
F Gumus, I Solak, M A Eryilmaz
OBJECTIVE: The aim of this study was to compare the Neutrophil to Lymphocyte ratio (NLR), Platelet to Lymphocyte ratio (PLR) and Mean Platelet Volume to Platelet (MPV/Plt) ratio of smokers and non-smokers. METHODS: Two hundred smokers and two hundred non-smoking healthy volunteers were enrolled in this study. Sociodemographic data and hematologic parameters of all patients were recorded. NLR, PLR and MPV/Plt ratios were calculated. RESULTS: The mean age of the case group was 35...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29455048/a-clinical-prediction-score-to-determine-surgical-drainage-of-deep-neck-infection-a-retrospective-case-control-study
#10
Myung Jin Ban, Jae Yeup Jung, Jae Wook Kim, Ki Nam Park, Seung Won Lee, Yoon Woo Koh, Jae Hong Park
BACKGROUND: The objective of this retrospective study was to identify predictors of an abscess guaranteed to be surgically drained successfully in patients with deep neck infection (DNI). MATERIALS AND METHODS: We divided 97 consecutive patients with DNI into a drained group and a non-drained group. We then developed a clinical prediction score and validated it in 32 further patients. RESULTS: Significant predictors of successful surgical drainage (i...
February 15, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29454639/neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-and-c-reactive-protein-as-new-and-simple-prognostic-factors-in-patients-with-metastatic-renal-cell-cancer-treated-with-tyrosine-kinase-inhibitors-a-systemic-review-and-meta-analysis
#11
Aleksandra Semeniuk-Wojtaś, Arkadiusz Lubas, Rafał Stec, Tomasz Syryło, Stanisław Niemczyk, Cezary Szczylik
BACKGROUND: Inflammation plays a crucial role in cancer development. In this study, we evaluate the prognostic values of systemic inflammation markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP) for the progression-free survival and overall survival in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors. MATERIALS AND METHODS: PubMed and the Cochrane Library databases were searched for published studies on the effect of NLR, PLR, and CRP in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors...
February 2, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29453243/peak-perihemorrhagic-edema-correlates-with-functional-outcome-in-intracerebral-hemorrhage
#12
Bastian Volbers, Antje Giede-Jeppe, Stefan T Gerner, Jochen A Sembill, Joji B Kuramatsu, Stefan Lang, Hannes Lücking, Dimitre Staykov, Hagen B Huttner
OBJECTIVE: To evaluate the association of perihemorrhagic edema (PHE) evolution and peak edema extent with day 90 functional outcome in patients with intracerebral hemorrhage (ICH) and identify pathophysiologic factors influencing edema evolution. METHODS: This retrospective cohort study included patients with spontaneous supratentorial ICH between January 2006 and January 2014. ICH and PHE volumes were studied using a validated semiautomatic volumetric algorithm...
February 16, 2018: Neurology
https://www.readbyqxmd.com/read/29452544/can-combined-blood-neutrophil-to-lymphocyte-ratio-and-c-reactive-protein-be-used-for-diagnosis-of-spontaneous-bacterial-peritonitis
#13
N Mousa, T Besheer, A Abdel-Razik, M Hamed, A G Deiab, T Sheta, W Eldars
BACKGROUND AND OBJECTIVE: Spontaneous bacterial peritonitis (SBP) is diagnosed by the presence of ≥250 polymorphonuclear neutrophils (PMN)/mm 3 in the ascites and the absence of surgically treatable cause of intra-abdominal infection. Blood neutrophil lymphocytic ratio (NLR) is an inexpensive and simple test for inflammation. C-reactive protein (CRP) is an inflammatory marker used for the diagnosis and follow-up of many diseases and morbidities. We aimed to evaluate the clinical utility of combined blood NLR and CRP as a non-invasive test for SBP diagnosis...
February 16, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29448304/neutrophil-lymphocyte-ratio-as-a-method-of-predicting-complications-following-hepatic-resection-for-colorectal-liver-metastasis
#14
Simon J McCluney, Alexandros Giakoustidis, Angela Segler, Juliane Bissel, Roberto Valente, Robert R Hutchins, Ajit T Abraham, Satyajit Bhattacharya, Hemant M Kocher
BACKGROUND AND OBJECTIVES: Approximately 30-50% of patients with colorectal cancer develop liver metastasis for which liver resection is the only hope for potential cure. However, hepatic resection is associated with considerable morbidity. The aim was to detect early complications by utilising the neutrophil: lymphocyte ratio (NLR). METHODS: We performed a retrospective cohort study of patients undergoing hepatic resection at a single institution between 2008 and 2016...
February 15, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29448179/elevated-neutrophil-to-lymphocyte-ratio-in-non-affective-psychotic-adolescent-inpatients-evidence-for-early-association-between-inflammation-and-psychosis
#15
Yael Bustan, Adi Drapisz, David H Ben Dor, Matan Avrahami, Maya Schwartz-Lifshitz, Abraham Weizman, Ran Barzilay
Accumulating data suggest an association between inflammation and schizophrenia and related psychosis. While several studies have established this immune-psychosis association in adult schizophrenia patients, there is very limited data associating inflammation with acute psychosis in children and adolescents. The ratio between neutrophils and lymphocyte, computed from routine blood counts, has been shown to correlate with traditional markers of inflammation, and is therefore considered a proxy-marker for inflammation...
February 12, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29448043/estrogen-serum-concentration-affects-blood-immune-cell-composition-and-polarization-in-human-females-under-controlled-ovarian-stimulation
#16
Pardes Habib, Daniela Dreymueller, Benjamin Rösing, Hannes Botung, Alexander Slowik, Adib Zendedel, Shahin Habib, Stefanie Hoffmann, Cordian Beyer
Estrogens modulate the immune system and possess anti-inflammatory properties. In line, immune cells express a variety of estrogen receptors (ER) including ER-alpha and -beta. In the present study, we examined the influence of 17beta-estradiol (E2) serum concentrations on blood leukocyte composition and their ex vivo polarization/activation status by FACS analysis in sub-fertile human females under controlled ovarian stimulation (COS). Using a set of cell-type and polarization-specific markers, we demonstrate that increased 17ß-estradiol (E2) serum concentrations yield an overall increase in leukocytes, neutrophils and monocytes but decreased lymphocytes...
February 12, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29447258/the-time-series-behavior-of-neutrophil-to-lymphocyte-ratio-is-useful-as-a-predictive-marker-in-non-small-cell-lung-cancer
#17
Tatsunori Kiriu, Masatsugu Yamamoto, Tatsuya Nagano, Daisuke Hazama, Reina Sekiya, Masahiro Katsurada, Daisuke Tamura, Motoko Tachihara, Kazuyuki Kobayashi, Yoshihiro Nishimura
BACKGROUND: Nivolumab improves the survival of advanced non-small cell lung cancer (NSCLC), but a significant number of patients still fail to benefit from this treatment. In this study, we evaluated the efficacy of the time-series behavior of neutrophil-to-lymphocyte ratio (NLR) in a complete blood count from advanced NSCLC patients as a predictive marker of the anticancer effect of nivolumab. METHODS: We performed a retrospective review of medical records and collected data on patients with advanced NSCLC treated with nivolumab as second- and further-line treatments from December 2015 to March 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29445100/pretreatment-inflammatory-indexes-as-prognostic-predictors-for-survival-in-colorectal-cancer-patients-receiving-neoadjuvant-chemoradiotherapy
#18
Jing Yang, Hui Xu, Xinli Guo, Jing Zhang, Xiaoyang Ye, Yanping Yang, Xuelei Ma
This study was to evaluate the prognostic value of pretreatment inflammatory indexes including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) in colorectal cancer (CRC) patients receiving neoadjuvant chemoradiotherapy (CRT). We enrolled 98 eligible CRC patients and divided them into high or low NLR, PLR, LMR, and SII groups according to their median index value, respectively. Univariate and multivariate analysis were performed to identify the potential predictors of progression-free survival (PFS) and overall survival (OS)...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29442281/neutrophil-to-lymphocyte-ratio-as-an-early-marker-of-outcomes-in-patients-with-advanced-non-small-cell-lung-cancer-treated-with-nivolumab
#19
Aya Nakaya, Takayasu Kurata, Hiroshige Yoshioka, Yuki Takeyasu, Maiko Niki, Kayoko Kibata, Naoko Satsutani, Makoto Ogata, Takayuki Miyara, Shosaku Nomura
BACKGROUND: There is an unmet need to identify markers that predict the response to nivolumab in patients with non-small-cell lung cancer (NSCLC). The neutrophil-to-lymphocyte ratio (NLR) was recently recognized as an indicator of a poor prognosis in patients with various cancers. In the present study, we quantified the predictive impact of NLR in patients with NSCLC treated with nivolumab. METHODS: We retrospectively analyzed 101 patients with advanced NSCLC treated with nivolumab at Kansai Medical University Hospital from December 2015 to December 2016...
February 13, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29442162/prognostic-meaning-of-neutrophil-to-lymphocyte-ratio-nlr-and-lymphocyte-to-monocyte-ration-lmr-in-newly-diagnosed-hodgkin-lymphoma-patients-treated-upfront-with-a-pet-2-based-strategy
#20
Alessandra Romano, Nunziatina Laura Parrinello, Calogero Vetro, Annalisa Chiarenza, Claudio Cerchione, Massimo Ippolito, Giuseppe Alberto Palumbo, Francesco Di Raimondo
Recent reports identify NLR (the ratio between absolute neutrophils counts, ANC, and absolute lymphocyte count, ALC), as predictor of progression-free survival (PFS) and overall survival (OS) in cancer patients. We retrospectively tested NLR and LMR (the ratio between absolute lymphocyte and monocyte counts) in newly diagnosed Hodgkin lymphoma (HL) patients treated upfront with a PET-2 risk-adapted strategy. NLR and LMR were calculated using records obtained from the complete blood count (CBC) from 180 newly diagnosed HL patients...
February 14, 2018: Annals of Hematology
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