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neutrophil lymphocyte ratio

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https://www.readbyqxmd.com/read/29684383/prognostic-role-of-haematological-indices-in-sudden-sensorineural-hearing-loss-review-and-meta-analysis
#1
REVIEW
Zaizai Cao, Ziyue Li, Haijie Xiang, Saiyu Huang, Jinjian Gao, Xiang Zhan, Xiuxiu Zhen, Bangliang Li, JianBin Wu, Bobei Chen
BACKGROUND: Complete blood count (CBC) is an important blood test in clinical practice, and it has been recently used to predict the prognosis of patients with sudden sensorineural hearing loss (SSNHL). Some haematological indices of the CBC test have been reported to be associated with the clinical outcome of SSNHL. However, the prognostic value of these haematological indices in SSNHL is currently under debate. Here, we performed a meta-analysis to investigate the association between haematological indices of the CBC test and clinical outcomes in patients with SSNHL...
April 20, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29682199/non-secretion-of-afp-and-neutrophil-lymphocyte-ratio-as-predictors-for-survival-in-hepatocellular-carcinoma-patients-treated-with-sorafenib-a-large-uk-cohort
#2
Mehran Afshar, Peter Fletcher, Antonio D Bardoli, Yuk Ting Ma, Pankaj Punia
Background: Sorafenib is the current standard of care for patients with advanced or metastatic hepatocellular carcinoma. Currently no universally agreed model exists correlating the Neutrophil Lymphocyte ratio (NLR) and non-secretion of AFP with the survival of HCC patients treated with sorafenib. Patients and Methods: We retrospectively analysed patient records with a confirmed diagnosis of HCC treated with sorafenib between April 2009 and March 2014. Survival analysis was performed using the Kaplan-Meier method and Cox regression...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29679522/oropharyngeal-squamous-cell-carcinoma-induces-an-innate-systemic-inflammation-affected-by-the-size-of-the-tumor-and-the-lymph-node-spread
#3
Åsa Kågedal, Camilla Rydberg Millrud, Valtteri Häyry, Susanna Kumlien Georén, Mats Lidegran, Eva Munck-Wikland, Lars Olaf Cardell
OBJECTIVES: Inflammation is known to be associated with the progression of cancer. The study was designed to characterize the systemic inflammation in patients with oropharyngeal squamous cell carcinoma (OPSCC) and investigate its relation to tumor size, ability to metastasize and HPV status. MATERIALS AND METHODS: Blood was obtained from 58 patients with OPSCC and 90 healthy controls and analyzed with leukocyte differential count. RESULTS: The OPSCC patients displayed an increased number of neutrophils and monocytes, whereas the lymphocytes were suppressed compared to the healthy controls...
April 21, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29676642/immunomethylomics-a-novel-cancer-risk-prediction-tool
#4
Karl T Kelsey, John K Wiencke
There is emerging evidence that the immune biology associated with lung and other solid tumors, as well as patient immune genetic traits, contributes to individual survival. At this time, dramatic advances in immunologic approaches to the study and management of human cancers are taking place, including lung and head and neck squamous cell carcinoma. However, major obstacles for therapies are the profound immune alterations in blood and in the tumor microenvironment that arise in tandem with the cancer. Although there is a significant current effort underway across the cancer research community to probe the tumor environment to uncover the dynamics of the immune response, little similar work is being done to understand the dynamics of immune alterations in peripheral blood, despite evidence showing the prognostic relevance of the neutrophil/lymphocyte ratio for these cancers...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29675097/diagnostic-accuracy-of-inflammatory-markers-for-distinguishing-malignant-and-benign-ovarian-masses
#5
Wan Kyu Eo, Ki Hyung Kim, Eun Joo Park, Heung Yeol Kim, Hong-Bae Kim, Suk Bong Koh, Jeong Namkung
Objective : To evaluate the role of inflammatory markers for distinguishing malignant and benign ovarian masses. Methods : Preoperative demographic, clinicopathologic, and laboratory variables were reviewed in patients with an ovarian mass that was subsequently diagnosed as either epithelial ovarian cancer (EOC) or a benign ovarian mass on histologic analysis. The differences between variables of the two groups were further evaluated. Logistic regression analysis was applied to evaluate variables to predict the presence of EOC...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29675093/prognostic-value-of-preoperative-lymphocyte-monocyte-ratio-in-patients-with-ovarian-clear-cell-carcinoma
#6
Byung Su Kwon, Dae Hoon Jeong, Jung Mi Byun, Tae Hwa Lee, Kyung Un Choi, Yong Jung Song, Dong Soo Suh, Ki Hyung Kim
Objective: The aim of the present study was to determine the prognostic significances of markers of preoperative systemic inflammatory response (SIR) in patients with ovarian clear cell carcinoma (OCCC). Methods: A total of 109 patients diagnosed with OCCC that underwent primary cytoreductive surgery and adjuvant platinum-based chemotherapy from 2009 to 2012 were enrolled in this retrospective study. SIR markers were calculated from complete blood cell counts determined before surgery. Receiver operating characteristic (ROC) curve analysis was used to determine optimal cut-off values for neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR)...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29673825/early-prediction-of-poor-outcome-despite-successful-recanalization-after-endovascular-treatment-for-anterior-large-vessel-occlusion-stroke
#7
Huaiming Wang, Meng Zhang, Yonggang Hao, Wenjie Zi, Dong Yang, Zhiming Zhou, Yu Geng, Zhen Wang, Hua Li, Gelin Xu, Graeme J Hankey, Yunyun Xiong, Xinfeng Liu
OBJECTIVE: Successful recanalization (SR) of the occluded artery does not always translate into a good outcome for patients with acute anterior circulation large-vessel occlusion stroke. This study aimed to develop a scale to predict poor outcome early despite SR after endovascular treatment (EVT) for candidates identified using current guidelines. METHODS: The eligible patients with SR were retrospectively enrolled between 2014 and 2016. Poor outcome was defined as modified Rankin Scale of 3 to 6 at 90 days...
April 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29673675/the-association-between-in-vitro-fertilization-outcome-and-the-inflammatory-markers-of-complete-blood-count-among-nonobese-unexplained-infertile-couples
#8
Esra Nur Tola
OBJECTIVE(S): The purpose of our study was to evaluate whether the inflammatory parameters of complete blood count (CBC), including white blood cell (WBC), neutrophil-to-lymphocyte-ratio (NLR), platelet-to-lymphocyte-ratio (PLR), and mean platelet volume (MPV), had potential roles in the etiopathogenesis of unexplained infertility (UI) among nonobese women. We also aimed to investigate whether there could be an association between these markers and in vitro fertilization (IVF) success among nonobese women with UI...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673584/a-30-minutes-supraceliac-aortic-clamping-in-the-rat-causes-death-due-to-an-inflammatory-response-and-pulmonary-lesions
#9
Antoine Monnot, Anaïs Dumesnil, Sylvanie Renet, Marie Laurence Roquet, Vincent Richard, Didier Plissonnier
BACKGROUND: The treatment of thoraco-abdominal aortic aneurysms through an open approach has general and pulmonary consequences of multiple etiologies. Our assumption was that the supraceliac aortic clamping needed for this operation causes a systemic inflammatory response associated with a pulmonary attack. MATERIAL AND METHODS: We developed a model of 30 min supraceliac aortic clamping in Wistar rats weighing 300 g. After 90 min of reperfusion the rats were sacrificed...
April 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29672849/baseline-neutrophilia-derived-neutrophil-to-lymphocyte-ratio-dnlr-platelet-to-lymphocyte-ratio-plr-and-outcome-in-non-small-cell-lung-cancer-nsclc-treated-with-nivolumab-or-docetaxel
#10
Alessandro Russo, Tindara Franchina, Giuseppina R R Ricciardi, Alessandra Battaglia, Antonino Scimone, Rosa Berenato, Antonio Giordano, Vincenzo Adamo
Nivolumab is a novel therapeutic option in NSCLC, associated with a significant survival gain compared with Docetaxel. However, predictive biomarkers are lacking. The presence of systemic inflammation has been correlated with poor outcome in many cancer types. We aimed to evaluate whether there is a correlation between some indicators of inflammation and response to Nivolumab or Docetaxel in pre-treated NSCLCs. Data of 62 patients receiving Nivolumab or Docetaxel were analyzed. Baseline neutrophilia and thrombocytosis were not associated with response...
April 19, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29670365/prognostic-value-of-platelet-to-lymphocyte-ratio-in-pancreatic-cancer-a-comprehensive-meta-analysis-of-17-cohort-studies
#11
REVIEW
Yongping Zhou, Sijin Cheng, Abdel Hamid Fathy, Haixin Qian, Yongzhao Zhao
Background and aims: Several studies were conducted to explore the prognostic value of platelet-to-lymphocyte ratio (PLR) in pancreatic cancer and have reported contradictory results. This study aims to summarize the prognostic role of PLR in pancreatic cancer. Materials and methods: Embase, PubMed and Cochrane Library were completely searched. The cohort studies focusing on the prognostic role of PLR in pancreatic cancer were eligible. The overall survival (OS) and progression-free survival (PFS) were analyzed...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29670115/clinicopathological-and-prognostic-significance-of-high-circulating-lymphocyte-ratio-in-patients-receiving-neoadjuvant-chemotherapy-for-advanced-gastric-cancer
#12
Yang Li, Yao Wei, Qi He, Xulin Wang, Chaogang Fan, Guoli Li
This study was designed to investigate the prognostic value of circulating blood cell counts and subsets for patients with advanced gastric cancer (AGC) treated with neoadjuvant chemotherapy (NAC) and the factors determining pathological complete response (pCR). In 112 patients with AGC, we retrospectively examined the ratios of lymphocyte, monocyte, and neutrophil during and after NAC before surgery, and the percentages of CD3+, CD3+ CD4+, CD3+ CD8+ and CD4+/CD8+ lymphocytes as well. We also investigated their associations with the pCR rate and overall survival (OS)...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669528/prognostic-value-of-systemic-inflammatory-markers-in-ovarian-cancer-a-prisma-compliant-meta-analysis-and-systematic-review
#13
Ying Zhu, Sanqin Zhou, Yang Liu, Lingyun Zhai, Xiwen Sun
BACKGROUND: The prognostic effect of elevated systemic inflammatory markers, including neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), remains controversial in cancer patients. This meta-analysis was conducted to evaluate the predictive values of these markers for prognoses in ovarian cancer patients. METHODS: Potentially relevant publications in PubMed, ISI Web of Science, and EBSCO were searched. Pooled hazard ratios (HRs) and corresponding 95% confidence intervals (95% CIs) for overall survival (OS) and progression-free survival (PFS) were determined using a fixed or random effects model...
April 18, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29668734/prognostic-value-of-hematological-parameters-in-patients-with-acute-myocardial-infarction-intrahospital-outcomes
#14
José Gildo de Moura Monteiro Júnior, Dilênia de Oliveira Cipriano Torres, Maria Cleide Freire Clementino da Silva, Cyntia Maria de Holanda Martins, Izadora Karina da Silva, Monique Evelyn Mendonça do Nascimento, Ana Célia Oliveira Dos Santos, Ulisses Ramos Montarroyos, Dário Celestino Sobral Filho
BACKGROUND: The intensity of the inflammatory response and hemodynamic repercussion in acute myocardial infarction causing the presence in the peripheral circulation of nucleated red blood cells (NRBCs), increases in mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) are associated with a poorer prognosis. The aim of this study was to assess the role of these hematological biomarkers as predictors of all causes of mortality during the hospitalization of patients with acute myocardial infarction...
2018: PloS One
https://www.readbyqxmd.com/read/29665145/serum-levels-of-albumin-and-prealbumin-do-not-correlate-with-nutrient-delivery-in-surgical-intensive-care-unit-patients
#15
D Dante Yeh, Emily Johnson, Tara Harrison, Haytham M A Kaafarani, Jarone Lee, Peter Fagenholz, Noelle Saillant, Yuchiao Chang, George Velmahos
BACKGROUND: Serum albumin and prealbumin levels, may be more strongly associated with inflammation than with nutrient delivery. Their predictive value has not been extensively described in surgical intensive care unit (ICU) patients. METHODS: We analyzed a registry of adult surgical ICU patients receiving enteral nutrition. Subjects with at least 1 serum albumin, prealbumin, or C-reactive protein (CRP) level were included. Demographic, nutrition, and clinical outcome data were collected...
April 17, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29663997/-predictive-value-of-inflammatory-markers-for-acute-kidney-injury-in-sepsis-patients-analysis-of-753-cases-in-7-years
#16
Xiao Zhou, Jingfeng Liu, Xiaojun Ji, Xiaowei Yang, Meili Duan
OBJECTIVE: To evaluate different inflammation markers for predicting the risk of acute kidney injury (AKI) in sepsis patients. METHODS: A retrospective observational study was conducted. The adult patients with sepsis for more than 24 hours admitted to intensive care unit (ICU) of Beijing Friendship Hospital, Capital Medical University from March 1st, 2010 to November 1st, 2017 were enrolled. Inflammatory markers such as white blood cell count (WBC), erythrocyte sedimentation rata (ESR), neutrophil and lymphocyte ratio (NLR), C-reactive protein (CRP), procalcitonin (PCT), etc...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663110/neutrophil-lymphocyte-and-platelet-counts-and-risk-of-prostate-cancer-outcomes-in-white-and-black-men-results-from-the-search-database
#17
Adriana C Vidal, Lauren E Howard, Amanda de Hoedt, Matthew R Cooperberg, Christopher J Kane, William J Aronson, Martha K Terris, Christopher L Amling, Emanuela Taioli, Jay H Fowke, Stephen J Freedland
PURPOSE: Systemic inflammation, as measured by C-reactive protein, has been linked with poor prostate cancer (PC) outcomes, predominantly in white men. Whether other immune measures like white blood cell counts are correlated with PC progression and whether results vary by race is unknown. We examined whether complete blood count (CBC) parameters were associated with PC outcomes and whether these associations varied by race. METHODS: Analyses include 1,826 radical prostatectomy patients from six VA hospitals followed through medical record review for biochemical recurrence (BCR)...
April 17, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29662758/neutrophil-to-lymphocyte-ratio-shows-faster-changing-kinetics-than-c-reactive-protein-after-total-hip-and-knee-arthroplasty
#18
Marcin Krzysztof Wasko, Marek Struminski, Konstancja Bobecka-Wesolowska, Jacek Kowalczewski
Background: Total hip arthroplasty (THA) and total knee arthroplasty (TKA) induce inflammatory reactions, which can be described by changes in the neuroendocrine, cellular, protein, and cytokine systems. The aim of this study was to document the normal distribution pattern of the neutrophil-to-lymphocyte ratio (NLR) after THA and TKA and to compare it with postoperative C-reactive protein (CRP) patterns. Methods: Changes in serum CRP levels, neutrophil count, and lymphocyte count were measured before and during the first 5 postoperative days in a prospective study performed on 387 patients undergoing total hip or knee arthroplasty...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29661142/neutrophils-in-primary-gastric-tumors-are-correlated-with-neutrophil-infiltration-in-tumor-draining-lymph-nodes-and-the-systemic-inflammatory-response
#19
Soichiro Hiramatsu, Hiroaki Tanaka, Junya Nishimura, Chie Sakimura, Tatsuro Tamura, Takahiro Toyokawa, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Tumor-Associated Neutrophils (TANs) may be able to induce lymphangiogenesis and angiogenesis, although the detailed roles of TANs remain unclear. The Neutrophil-Lymphocyte Ratio (NLR) is an inflammation-based prognostic factor for gastric cancer. This study aimed to investigate the distribution of CD15+ neutrophils in the primary tumor and Tumor-Draining Lymph Nodes (TDLNs), and to examine the association of TANs with the clinicopathological features (including NLR) of patients with gastric cancer...
April 16, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29660970/inflammation-and-rehabilitation-outcomes-in-patients-with-nontraumatic-intracranial-haemorrhage
#20
Mirella Boselli, Roberto Aquilani, Roberto Maestri, Maria Pia Achilli, Nadia Arrigoni, Evasio Pasini, Anna Maria Condino, Federica Boschi, Maurizia Dossena, Daniela Buonocore, Manuela Verri
BACKGROUND: Systemic inflammation and its impact on rehabilitation for patients with non-traumatic haemorrhagic injury (HBI) sequelae has not yet been adequately documented. OBJECTIVE AND METHODS: We therefore considered 31 patients with HBI, to determine the serum levels of inflammatory markers (C-Reactive Protein, CRP and or interleukine-6, IL-6) to establish their impact on functional status (Functional Independence Measure, FIM: 18 indicating the worst performance and 126, a normal score)...
April 7, 2018: NeuroRehabilitation
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