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neutrophil lymphocyte ratio

Pavel Poredoš
No abstract text is available yet for this article.
June 2018: VASA. Zeitschrift Für Gefässkrankheiten
Mari Ohtaka, Takashi Kawahara, Daiji Takamoto, Taku Mochizuki, Hiroaki Ishida, Yusuke Hattori, Kazuhide Makiyama, Masahiro Yao, Jun-Ichi Teranishi, Hiroji Uemura
OBJECTIVES: Because of recent developments in immunosuppressive therapy, renal transplant outcomes have improved. Although reports on the association between immunosuppressive therapy and malignant disease are available, the results are controversial. The neutrophil-to-lymphocyte ratio has been reported as an easy tumor marker for predicting the prognoses of some solid tumors. In the present study, we examined changes in neutrophil-to-lymphocyte ratio after renal transplant and discussed cases in which malignant disease developed after renal transplant...
June 18, 2018: Experimental and Clinical Transplantation
Lauren Winter, Lydia A Wong, George Jerums, Jas-Mine Seah, Michele Clarke, Sih Min Tan, Melinda T Coughlan, Richard J MacIsaac, Elif I Ekinci
Diabetic kidney disease is a common complication of type 1 and type 2 diabetes and is the primary cause of end-stage renal disease in developed countries. Early detection of diabetic kidney disease will facilitate early intervention aimed at reducing the rate of progression to end-stage renal disease. Diabetic kidney disease has been traditionally classified based on the presence of albuminuria. More recently estimated glomerular filtration rate has also been incorporated into the staging of diabetic kidney disease...
2018: Frontiers in Endocrinology
E Gabriela Chiorean, Daniel Von Hoff, Yin Wan, Sandra Margunato-Debay, Marc Botteman, David Goldstein
Objectives: This analysis examined changes in Karnofsky performance status (KPS) as a surrogate for patient's well-being during treatment with nab -paclitaxel plus gemcitabine vs gemcitabine alone as first-line therapy for metastatic pancreatic cancer (MPC) in the Phase III MPACT trial. Participants and methods: Descriptive analyses were performed for KPS at three time points (3 and 6 months after randomization and 1 month before disease progression) and for time to any KPS deterioration...
2018: Cancer Management and Research
Mamoru Hashimoto, Naoki Matsumura, Takayuki Ohzeki, Sachiko Hongo, Koichi Sugimoto, Nobutaka Shimizu, Yasunori Mori, Takafumi Minami, Masahiro Nozawa, Kazuhiro Nose, Hideo Tahara, Kazuhiro Yoshimura, Hirotsugu Uemura
INTRODUCTION: We investigated whether the change in the neutrophil lymphocyte ratio (NLR) from the first to the last repeat prostate biopsy (ΔNLR) could be the diagnostic tool or not for prostate cancer (PCa) detection. MATERIALS AND METHODS: We retrospectively evaluated medical records of men who had undergone repeat prostate biopsy. The investigated parameters were white blood cell, neutrophil, lymphocyte counts, NLR at the last prostate biopsy, ΔNLR, prostate-specific antigen (PSA), PSA density (PSAD), and PSA velocity...
June 15, 2018: Urologia Internationalis
Ping Tan, Hang Xu, Liangren Liu, Jianzhong Ai, Huan Xu, Yong Jiang, Xiaoyu Zhang, Lu Yang, Qiang Wei
BACKGROUND: We evaluated the prognostic impact of the preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy treatment. METHODS: A total of 717 patients were identified between 2003 and 2016. The cutoff value of NLR was set as 2.5. Kaplan-Meier method and Cox's proportional hazards regression models were utilized to analyze the association between NLR and oncological outcomes. RESULTS: The median follow-up was 42 months...
June 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Ryoko Suzuki, Xiong Wei, Pamela K Allen, James W Welsh, Ritsuko Komaki, Steven H Lin
BACKGROUND AND PURPOSE: We sought factors associated with the development of brain metastases after treatment of small cell lung cancer (SCLC) in patients without brain involvement at diagnosis. METHODS: We analyzed 293 patients with SCLC without brain metastases who received chemotherapy, thoracic radiation therapy (TRT), or both in 2001-2015. Pretreatment hematologic markers (platelet count, neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lactate dehydrogenase) and other clinical characteristics were evaluated for correlation with brain metastases-free survival (BMFS)...
June 12, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Andrei M Beliaev, Michael Booth, David Rowbotham, Colleen Bergin
BACKGROUND: The 2018 Tokyo guidelines for acute cholangitis (AC) use white cell count (WCC) as one of the diagnostic criteria. However, the 2018 Tokyo guidelines grading does not provide guidance for AC patients with normal WCC. In this situation, other inflammatory biomarkers also can be used to diagnose AC and grade severity, but their diagnostic values are yet undetermined. The aims of this study were to evaluate the discriminative powers of common inflammatory markers compared with WCC for diagnosing AC and to determine their diagnostic cutoff levels...
August 2018: Journal of Surgical Research
Rajan K Thakkar, Zachary Diltz, Joseph D Drews, Krista K Wheeler, Junxin Shi, Racheal Devine, Renata Fabia, Mark Hall
BACKGROUND: Burns are a leading cause of morbidity in children, with infections representing the most common group of complications. Severe thermal injuries are associated with a profound inflammatory response, but the utility of laboratory values to predict infections in pediatric burn patients is poorly understood. MATERIALS AND METHODS: Our institutional burn database was queried for patients aged 18 y and younger with at least 10% total body surface area burns...
August 2018: Journal of Surgical Research
Murat Cikot, Pinar Kasapoglu, Nilgun Isiksacan, Sinan Binboga, Osman Kones, Eyup Gemici, Bahadır Kartal, Halil Alis
BACKGROUND: Early diagnosis of anastomotic leakage is the most important factor in reducing its morbidity and mortality. Anastomotic integrity monitoring of the leukocyte count (WBC), C-reactive protein (CRP), and neutrophil-lymphocyte ratio (NLR) are commonly used laboratory parameters. The availability of follow-up presepsin anastomotic integrity was investigated in this study. MATERIALS AND METHODS: This study included patients who had gastrointestinal anastomosis due to major abdominal surgery between January 2016 and February 2017...
August 2018: Journal of Surgical Research
Stefan Buettner, Gaya Spolverato, Charles W Kimbrough, Sorin Alexandrescu, Hugo P Marques, Jorge Lamelas, Luca Aldrighetti, T Clark Gamblin, Shishir K Maithel, Carlo Pulitano, Matthew Weiss, Todd W Bauer, Feng Shen, George A Poultsides, J Wallis Marsh, Jan N M IJzermans, Bas Groot Koerkamp, Timothy M Pawlik
BACKGROUND: Neutrophil-to-lymphocyte ratio and platelets-to-lymphocyte ratio may be host factors associated with prognosis. We sought to determine whether neutrophil-to-lymphocyte and platelets-to-lymphocyte ratio were associated with overall survival among patients undergoing surgery for intrahepatic cholangiocarcinoma. METHODS: Patients who underwent resection for intrahepatic cholangiocarcinoma between 1990 and 2015 were identified from 12 major centers. Clinicopathologic factors and overall survival were compared among patients stratified by neutrophil-to-lymphocyte ratio and platelets-to-lymphocyte ratio...
June 11, 2018: Surgery
Guoxing Wan, Lihua Ji, Wenbin Xia, Lan Cheng, Yonggang Zhang
Neutrophil‑to‑lymphocyte ratio (NLR) is commonly considered a useful prognostic index for many cardiovascular diseases; however, it has limited sensitivity and specificity. Factors associated with elevated NLR may aid in the prediction of prognosis with heart failure (HF) in combination with NLR. The present study sought to identify decisive factors associated with NLR in HF patients and investigate their association with elevated NLR. The gene expression profile for blood samples from 197 individuals with chronic heart failure (CHF), with corresponding hematological parameters and clinical data were obtained from the public database, GSE77343...
June 5, 2018: Molecular Medicine Reports
Mustafa Serdar Sağ, Sinem Sağ, İbrahim Tekeoğlu, Ayhan Kamanli, Kemal Nas, Halil Harman
Objectives: This study aims to investigate the association of pentraxin 3 (PTX3) with neutrophil/lymphocyte ratio (NLR) rather than the disease activity score 28 using C-reactive protein in rheumatoid arthritis (RA). Patients and methods: The study included 59 RA patients (11 males, 48 females; mean age 53.79±13.55 years; range 40 to 66 years) and 20 healthy controls (5 males, 15 females; mean age 50.41±6.11 years; range 43 to 56 years). Complete blood count tests were recorded and NLR and platelet/ lymphocyte ratio were calculated...
March 2018: Archives of Rheumatology
Hiromi Sasaki, Satoshi Nagano, Setsuro Komiya, Noboru Taniguchi, Takao Setoguchi
Predicting outcomes in patients with soft tissue sarcoma (STS) is challenging. To improve these predictions, we retrospectively analyzed common nutritional assessment systems, including Glasgow prognostic score (GPS), Geriatric Nutritional Risk Index (GNRI), neutrophil⁻lymphocyte ratio (NLR), platelet⁻lymphocyte ratio (PLR), and controlling nutritional (CONUT) score against outcomes in 103 patients with STS, of whom 15 (14.6%) died within 1 year of diagnosis. GPS, GNRI, NLR, PLR, and CONUT scores significantly differed between patients who died within one year and patients who lived longer...
June 13, 2018: Nutrients
Ono Takeharu, Koichi Azuma, Akihiko Kawahara, Jun Akiba, Tatsuyuki Kakuma, Shun-Ich Chitose, Hirohito Umeno
OBJECTIVES: Although inflammatory markers, such as the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and local immune markers have been shown to have prognostic utility, limited information is available regarding inflammatory and pre-existing tumor-infiltrating lymphocyte density and their association with prognosis in patients with hypopharyngeal squamous cell carcinoma. We investigated the prognostic ability of inflammatory markers and tumor-infiltrating lymphocyte density in stage III and IV hypopharyngeal squamous cell carcinoma patients receiving definitive treatment...
June 13, 2018: Clinical Otolaryngology
Xue Bao, Yan Borné, Linda Johnson, Iram Faqir Muhammad, Margaretha Persson, Kaijun Niu, Gunnar Engström
BACKGROUND: Chronic low-grade inflammation and associated insulin resistance and metabolic abnormalities have been proposed as 'common soil' for diabetes mellitus (DM) and cardiovascular disease (CVD). This paper aimed to investigate the inflammatory profiles of DM and CVD and to distinguish their shared and specific markers. METHODS: Based on the Malmö Diet and Cancer cohort, total and differential leukocyte counts were measured in 25,969 participants without previous DM or CVD and were studied in relation to incident DM (mean follow-up 17...
June 12, 2018: Cardiovascular Diabetology
Ekaterina V Pavlova, Galina S Alekseeva, Mariya N Erofeeva, Nina A Vasilieva, Andrey V Tchabovsky, Sergey V Naidenko
Blood analysis has recently become a popular tool to assess the welfare of the wild cats. However, the estimates of blood parameters may depend on the sampling method. We have tested (1) if the sampling procedure influences blood parameters and (2) what parameters are the most efficient in assessing the physiological status in wild cat species. We assessed the effect of handling time on red blood cells (RBC) and white blood cells (WBC) counts, the ratio of neutrophils to lymphocytes (N/L ratio), and serum cortisol level within 1 hr after the capture of the animal in six far-east wild cats (Prionailurus bengalensis euptilura)...
June 12, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
J Lee, M Y Kim, S H Kang, J Kim, Y Uh, K J Yoon, H S Kim
Objective Noninvasive liver fibrosis evaluation is an important issue in chronic hepatitis B infection, and may be assessed using transient elastography (Fibroscan) or with blood markers. We compared the value of Fibroscan with that of a panel of routine serum markers. Materials and methods We recruited 278 chronic hepatitis B patients who underwent Fibroscan and HBV DNA testing. Fibroscan assessments were made, and blood taken for the measurement of the gamma-glutamyl transferase (GGT) to platelet ratio (GPR), platelet count, aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), international normalised ratio (INR), total cholesterol, trigylcerides, bilirubin, mean platelet volume (MPV), AST to platelet ratio index (APRI) and neutrophil to lymphocyte ratio...
June 12, 2018: British Journal of Biomedical Science
Sezim Agizamhan, Feng Qu, Ning Liu, Jing Sun, Wei Xu, Lihua Zhang, Hongqian Guo, Weidong Gan
BACKGROUND: The preoperative neutrophil-to-lymphocyte ratio (NLR), C-reactive protein/albumin ratio (CRP/Alb ratio) and platelet-to-lymphocyte ratio (PLR) have been demonstrated to predict the clinical outcome of various human cancer, including renal cell carcinoma(RCC). The aim of our study was to explore the prognostic values of these ratios in patients with Xp11.2 translocation/TFE3 gene fusions renal cell carcinoma (Xp11.2 tRCC). METHODS: A retrospective multicentre study was performed in 82 Xp11...
June 11, 2018: BMC Urology
Luisa Berenise Gamez-Gonzalez, Isabel Moribe-Quintero, Martin Cisneros-Castolo, Javier Varela-Ortiz, Mireya Muñoz-Ramírez, Martin Garrido-García, Marco Yamazaki-Nakashimada
BACKGROUND: Kawasaki disease shock syndrome (KDSS) is an uncommon presentation of Kawasaki disease (KD). KDSS has been associated with more severe markers of inflammation, coronary abnormalities and IVIG resistance. METHODS: A retrospective, descriptive study of children with KDSS in two hospitals was performed. Relevant articles about KD and shock were collected, demographic data, clinical presentation, laboratory variables, echocardiogram findings, treatment and special features were analyzed when available...
June 11, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
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