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https://www.readbyqxmd.com/read/28428775/genomics-reveals-a-unique-clone-of-burkholderia-cenocepacia-harboring-an-actively-excising-novel-genomic-island
#1
Prashant P Patil, Swapna Mali, Samriti Midha, Vikas Gautam, Lona Dash, Sunil Kumar, Jayanthi Shastri, Lipika Singhal, Prabhu B Patil
Burkholderia cenocepacia is a clinically dominant form among the other virulent species of Burkholderia cepacia complex (Bcc). In the present study, we sequenced and analyzed the genomes of seven nosocomial Bcc isolates, five of which were isolated from the bloodstream infections and two isolates were recovered from the hospital setting during the surveillance. Genome-based species identification of the Bcc isolates using a type strain explicitly identified the species as B. cenocepacia. Moreover, single nucleotide polymorphism analysis revealed that the six isolates were clonal and phylogenetically distinct from the other B...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28422970/the-gut-microbiota-as-a-modulator-of-innate-immunity-during-melioidosis
#2
Jacqueline M Lankelma, Emma Birnie, Tassili A F Weehuizen, Brendon P Scicluna, Clara Belzer, Riekelt H Houtkooper, Joris J T H Roelofs, Alex F de Vos, Tom van der Poll, Andries E Budding, W Joost Wiersinga
BACKGROUND: Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an emerging cause of pneumonia-derived sepsis in the tropics. The gut microbiota supports local mucosal immunity and is increasingly recognized as a protective mediator in host defenses against systemic infection. Here, we aimed to characterize the composition and function of the intestinal microbiota during experimental melioidosis. METHODOLOGY/PRINCIPAL FINDINGS: C57BL/6 mice were infected intranasally with B...
April 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28418830/increased-neurotropic-threat-from-burkholderia-pseudomallei-strains-with-a-b-mallei-like-variation-in-the-bima-motility-gene-australia
#3
Jodie L Morris, Anne Fane, Derek S Sarovich, Erin P Price, Catherine M Rush, Brenda L Govan, Elizabeth Parker, Mark Mayo, Bart J Currie, Natkunam Ketheesan
Neurologic melioidosis is a serious, potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. pseudomallei from Australia have heightened virulence and potential for dissemination to the central nervous system. In this study, we demonstrate that this subset has a B. mallei-like sequence variation of the actin-based motility gene, bimA. Compared with B. pseudomallei isolates having typical bimA alleles, isolates that contain the B. mallei-like variation demonstrate increased persistence in phagocytic cells and increased virulence with rapid systemic dissemination and replication within multiple tissues, including the brain and spinal cord, in an experimental model...
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28417070/acute-bacteremic-pneumonia-due-to-melioidosis-developing-in-the-intensive-care-setting
#4
Huda Zainal Abidin, Alwi Muhd Besari, Chandran Nadarajan, Wan Fadzlina Wan Shukeri, Mohd Zulfakar Mazlan, Soon Eu Chong, Zeti Norfidiyati Salmuna Ayub
In Malaysia, melioidosis is commonly encountered as this infection is known as part of the endemic area for the disease. Managing cases of positive Burkholderia pseudomallei infection can involve multidisciplinary unit mainly, microbiologist, infectious disease team and intensive care as it may be quite difficult to distinguish melioidosis from a number of other diseases on the clinical setting alone. Laboratory diagnosis plays a vital role in determining the direction of management. Investigations such as culture, polymerase chain reaction (PCR) and serology should be evaluated once the disease is suspected...
2017: IDCases
https://www.readbyqxmd.com/read/28414823/comparing-in-vitro-and-in-vivo-virulence-phenotypes-of-burkholderia-pseudomallei-type-g-strains
#5
Eric R G Lewis, Paul B Kilgore, Tiffany M Mott, Gonzalo A Pradenas, Alfredo G Torres
Burkholderia pseudomallei (Bpm) is a saprophytic rod-shaped gram-negative bacterium and the causative agent of melioidosis. This disease has previously been described as endemic in areas such as northern Australia and Southeast Asia, but, more recently, a better understanding of the epidemiology of melioidosis indicated that the disease is distributed worldwide, including regions of the Americas and Africa. A 16S-23S rDNA internal transcribed spacer (ITS) typing system has been developed for Bpm and has revealed that ITS types C, E, and hybrid CE are mainly associated with Australia and Southeast Asia while type G strains are more associated with cases of melioidosis in the Western Hemisphere...
2017: PloS One
https://www.readbyqxmd.com/read/28414016/accidental-occupational-exposure-to-burkholderia-pseudomallei-in-south-korea-did-not-result-in-melioidosis
#6
Jae-Bum Jun, Taehoon Lee, Joseph Jeong, Jeong-Hoon Chun, Yong-Woo Shin, Jiwon Jung
No abstract text is available yet for this article.
April 17, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28400528/within-host-evolution-of-burkholderia-pseudomallei-during-chronic-infection-of-seven-australasian-cystic-fibrosis-patients
#7
Linda T Viberg, Derek S Sarovich, Timothy J Kidd, James B Geake, Scott C Bell, Bart J Currie, Erin P Price
Cystic fibrosis (CF) is a genetic disorder characterized by progressive lung function decline. CF patients are at an increased risk of respiratory infections, including those by the environmental bacterium Burkholderia pseudomallei, the causative agent of melioidosis. Here, we compared the genomes of B. pseudomallei isolates collected between ~4 and 55 months apart from seven chronically infected CF patients. Overall, the B. pseudomallei strains showed evolutionary patterns similar to those of other chronic infections, including emergence of antibiotic resistance, genome reduction, and deleterious mutations in genes involved in virulence, metabolism, environmental survival, and cell wall components...
April 11, 2017: MBio
https://www.readbyqxmd.com/read/28398677/preparing-for-biological-threats-addressing-the-needs-of-pregnant-women
#8
REVIEW
Amelia K Watson, Sascha Ellington, Christina Nelson, Tracee Treadwell, Denise J Jamieson, Dana M Meaney-Delman
Intentional release of infectious agents and biological weapons to cause illness and death has the potential to greatly impact pregnant women and their fetuses. We review what is known about the maternal and fetal effects of seven biological threats: Bacillus anthracis (anthrax); variola virus (smallpox); Clostridium botulinum toxin (botulism); Burkholderia mallei (glanders) and Burkholderia pseudomallei (melioidosis); Yersinia pestis (plague); Francisella tularensis (tularemia); and Rickettsia prowazekii (typhus)...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28396541/antibiotic-resistance-markers-in-strain-bp1651-of-burkholderia-pseudomallei-identified-by-genome-sequence-analysis
#9
Julia V Bugrysheva, David Sue, Jay E Gee, Mindy G Elrod, Alex R Hoffmaster, Linnell B Randall, Sunisa Chirakul, Apichai Tuanyok, Herbert P Schweizer, Linda M Weigel
Burkholderia pseudomallei Bp1651 is resistant to several classes of antibiotics that are usually effective for treatment of melioidosis including β-lactams such as penicillins (amoxicillin/clavulanic acid), cephalosporins (ceftazidime), carbapenems (imipenem and meropenem), as well as tetracyclines and sulfonamides. We sequenced, assembled, and annotated the Bp1651 genome, and analyzed the sequence using comparative genomic analyses with susceptible strains, keyword searches of the annotation, publicly available antimicrobial resistance prediction tools, and published reports...
April 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28394990/-burkholderia-pseudomallei-challenges-for-the-clinical-microbiology-laboratory
#10
Andrea Sakurada
No abstract text is available yet for this article.
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28386631/microbial-rhamnolipid-production-a-critical-re-evaluation-of-published-data-and-suggested-future-publication-criteria
#11
REVIEW
Victor U Irorere, Lakshmi Tripathi, Roger Marchant, Stephen McClean, Ibrahim M Banat
High production cost and potential pathogenicity of Pseudomonas aeruginosa, commonly used for rhamnolipid synthesis, have led to extensive research for safer producing strains and cost-effective production methods. This has resulted in numerous research publications claiming new non-pathogenic producing strains and novel production techniques many of which are unfortunately without proper characterisation of product and/or producing strain/s. Genes responsible for rhamnolipid production have only been confirmed in P...
April 6, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28386468/comparison-of-mast-burkholderia-cepacia-ashdown-gentamicin-and-burkholderia-pseudomallei-selective-agar-for-the-selective-growth-of-burkholderia-spp
#12
Carola Edler, Henri Derschum, Mirko Köhler, Heinrich Neubauer, Hagen Frickmann, Ralf Matthias Hagen
Reliable identification of pathogenic Burkholderia spp. like Burkholderia mallei and Burkholderia pseudomallei in clinical samples is desirable. Three different selective media were assessed for reliability and selectivity with various Burkholderia spp. and nontarget organisms. Mast Burkholderia cepacia agar, Ashdown + gentamicin agar, and B. pseudomallei selective agar were compared. A panel of 116 reference strains and well-characterized clinical isolates, comprising 30 B. pseudomallei, 20 B. mallei, 18 other Burkholderia spp...
March 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/28385830/whole-genome-sequences-of-burkholderia-pseudomallei-isolates-exhibiting-decreased-meropenem-susceptibility
#13
Erin P Price, Melissa Laird Smith, Ellen E Paxinos, Luke J Tallon, Lisa Sadzewicz, Naomi Sengamalay, Robert W Baird, Bart J Currie, Derek S Sarovich
We report here paired isogenic Burkholderia pseudomallei genomes obtained from three patients receiving intravenous meropenem for melioidosis treatment, with post-meropenem isolates developing decreased susceptibility. Two genomes were finished, and four were drafted to improved high-quality standard. These genomes will be used to identify meropenem resistance mechanisms in B. pseudomallei.
April 6, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28384252/matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-for-the-identification-of-burkholderia-pseudomallei-from-asia-and-australia-and-differentiation-between-burkholderia-species
#14
Vichaya Suttisunhakul, Apinya Pumpuang, Peeraya Ekchariyawat, Vanaporn Wuthiekanun, Mindy G Elrod, Paul Turner, Bart J Currie, Rattanaphone Phetsouvanh, David A B Dance, Direk Limmathurotsakul, Sharon J Peacock, Narisara Chantratita
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is increasingly used for rapid bacterial identification. Studies of Burkholderia pseudomallei identification have involved small isolate numbers drawn from a restricted geographic region. There is a need to expand the reference database and evaluate B. pseudomallei from a wider geographic distribution that more fully captures the extensive genetic diversity of this species. Here, we describe the evaluation of over 650 isolates...
2017: PloS One
https://www.readbyqxmd.com/read/28381962/computational-identification-and-comparative-analysis-of-secreted-and-transmembrane-proteins-in-six-burkholderia-species
#15
Thao Thi Nguyen, Hyun-Hee Lee, Jungwook Park, Inmyoung Park, Young-Su Seo
As a step towards discovering novel pathogenesis-related proteins, we performed a genome scale computational identification and characterization of secreted and transmembrane (TM) proteins, which are mainly responsible for bacteria-host interactions and interactions with other bacteria, in the genomes of six representative Burkholderia species. The species comprised plant pathogens (B. glumae BGR1, B. gladioli BSR3), human pathogens (B. pseudomallei K96243, B. cepacia LO6), and plant-growth promoting endophytes (Burkholderia sp...
April 2017: Plant Pathology Journal
https://www.readbyqxmd.com/read/28374071/biosynthesis-of-di-rhamnolipids-and-variations-of-congeners-composition-in-genetically-engineered-escherichia-coli
#16
Jin Du, Aijun Zhang, Jian'an Hao, Jing Wang
OBJECTIVES: To engineer Escherichia coli for the heterologous production of di-rhamnolipids, which are important biosurfactants but mainly produced by opportunistic pathogen Pseudomonas aeruginosa. RESULTS: The codon-optimized rhlAB and rhlC genes originating from P. aeruginosa and Burkholderia pseudomallei were combinatorially expressed in E. coli to produce di-rhamnolipids with varied congeners compositions. Genes involved in endogenous upstream pathways (rhamnose and fatty acids synthesis) were co-overexpressed with rhlAB-rhlC, resulting in variations of rhamnolipids production and congeners compositions...
April 3, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28358816/comparison-of-o-polysaccharide-and-hemolysin-co-regulated-protein-as-target-antigens-for-serodiagnosis-of-melioidosis
#17
Apinya Pumpuang, Susanna J Dunachie, Phornpun Phokrai, Kemajittra Jenjaroen, Kitisak Sintiprungrat, Siriphan Boonsilp, Paul J Brett, Mary N Burtnick, Narisara Chantratita
BACKGROUND: Melioidosis is a severe disease caused by Burkholderia pseudomallei. Clinical manifestations are diverse and acute infections require immediate treatment with effective antibiotics. While culture is the current diagnostic standard, it is time-consuming and has low sensitivity. In endemic areas, inaccessibility to biosafety level 3 facilities and a lack of good serodiagnostic tools can impede diagnosis and disease surveillance. Recent studies have suggested that O-polysaccharide (OPS) and hemolysin co-regulated protein 1 (Hcp1) are promising target antigens for serodiagnosis of melioidosis...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28351287/neuromelioidosis-a-series-of-seven-cases-in-hainan-province-china
#18
Yuefu Zhan, Yehua Wu, Qun Li, Anle Yu
Melioidosis, which is caused by Burkholderia pseudomallei, is predominately a disease of tropical climates and is especially widespread in south-east Asia and northern Australia. Melioidosis affecting the central nervous system has a low incidence but a high mortality. We present seven cases of neuromelioidosis and analyze the disease characteristics and imaging features. Typical clinical features of this disease included high fever and headache. Five patients had an irregular fever with a temperature ≥ 39℃...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28348862/whole-genome-sequencing-of-a-quarter-century-melioidosis-outbreak-in-temperate-australia-uncovers-a-region-of-low-prevalence-endemicity
#19
Stephanie N J Chapple, Derek S Sarovich, Matthew T G Holden, Sharon J Peacock, Nicky Buller, Clayton Golledge, Mark Mayo, Bart J Currie, Erin P Price
Melioidosis, caused by the highly recombinogenic bacterium Burkholderia pseudomallei, is a disease with high mortality. Tracing the origin of melioidosis outbreaks and understanding how the bacterium spreads and persists in the environment are essential to protecting public and veterinary health and reducing mortality associated with outbreaks. We used whole-genome sequencing to compare isolates from a historical quarter-century outbreak that occurred between 1966 and 1991 in the Avon Valley, Western Australia, a region far outside the known range of B...
July 2016: Microbial Genomics
https://www.readbyqxmd.com/read/28348161/loss-of-methyltransferase-function-and-increased-efflux-activity-leads-to-doxycycline-resistance-in-burkholderia-pseudomallei
#20
Jessica R Webb, Erin P Price, Bart J Currie, Derek S Sarovich
The soil-dwelling bacterium Burkholderia pseudomallei is the causative agent of the potentially fatal disease melioidosis. The lack of a vaccine towards B. pseudomallei means that melioidosis treatment relies on prolonged antibiotic therapy, which can last up to six months in duration or longer. Due to intrinsic resistance, few antibiotics are effective against B. pseudomallei The lengthy treatment regimen required increases the likelihood of resistance development, with subsequent potentially fatal relapse...
March 27, 2017: Antimicrobial Agents and Chemotherapy
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