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https://www.readbyqxmd.com/read/29780897/melioidosis-in-mexico-central-america-and-the-caribbean
#1
Javier I Sanchez-Villamil, Alfredo G Torres
Burkholderia pseudomallei is the causative agent of melioidosis, an endemic disease in tropical areas around the world. Cumulative human cases have demonstrated that melioidosis is prevalent and increasingly recognized in the American continent. Even though the first reports of melioidosis in Mexico, Central America, and the Caribbean Islands date back to the late 1940s, the potential of the disease as a public health concern in the region has not been fully appreciated. Unfortunately, recent studies predicting the global distribution of the disease and the demonstration of melioidosis endemicity in Puerto Rico have not increased recognition of the disease by health professionals in this region...
March 2018: Tropical Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29771915/inactivation-of-bpsl1039-1040-atp-binding-cassette-transporter-reduces-intracellular-survival-in-macrophages-biofilm-formation-and-virulence-in-the-murine-model-of-burkholderia-pseudomallei-infection
#2
Peechanika Pinweha, Pornpan Pumirat, Jon Cuccui, Niramol Jitprasutwit, Veerachat Muangsombut, Varintip Srinon, Usa Boonyuen, Parameth Thiennimitr, Paiboon Vattanaviboon, Felipe Cia, Sam Willcocks, Gregory J Bancroft, Brendan W Wren, Sunee Korbsrisate
Burkholderia pseudomallei, a gram-negative intracellular bacillus, is the causative agent of a tropical infectious disease called melioidosis. Bacterial ATP-binding cassette (ABC) transporters import and export a variety of molecules across bacterial cell membranes. At present, their significance in B. pseudomallei pathogenesis is poorly understood. We report here characterization of the BPSL1039-1040 ABC transporter. B. pseudomallei cultured in M9 medium supplemented with nitrate, demonstrated that BPSL1039-1040 is involved in nitrate transport for B...
2018: PloS One
https://www.readbyqxmd.com/read/29747543/activation-of-%C3%AE-and-%C3%AE-carbonic-anhydrases-from-pathogenic-bacteria-with-tripeptides
#3
Azzurra Stefanucci, Andrea Angeli, Marilisa Pia Dimmito, Grazia Luisi, Sonia Del Prete, Clemente Capasso, William A Donald, Adriano Mollica, Claudiu T Supuran
Six tripeptides incorporating acidic amino acid residues were prepared for investigation as activators of β- and γ-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic bacteria Vibrio cholerae, Mycobacterium tuberculosis, and Burkholderia pseudomallei. The primary amino acid residues that are involved in the catalytic mechanisms of these CA classes are poorly understood, although glutamic acid residues near the active site appear to be involved. The tripeptides that contain Glu or Asp residues can effectively activate VchCAβ and VchCAγ (enzymes from V...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29735757/malleilactone-is-a-burkholderia-pseudomallei-virulence-factor-regulated-by-antibiotics-and-quorum-sensing
#4
Jennifer R Klaus, Jacqueline Deay, Benjamin Neuenswander, Wyatt Hursh, Zhe Gao, Tiffany Bouddhara, Todd D Williams, Justin Douglas, Kyle Monize, Patricia Martins, Charlotte Majerczyk, Mohammad R Seyedsayamdost, Blake R Peterson, Mario Rivera, Josephine R Chandler
Burkholderia pseudomallei , the causative agent of melioidosis, encodes almost a dozen predicted polyketide (PK) biosynthetic gene clusters. Many of these are regulated by LuxR-I-type acyl-homoserine (AHL) quorum-sensing systems. One of the PK gene clusters, the mal gene cluster, is conserved in the close relative Burkholderia thailandensis. The B. thailandensis mal genes code for the cytotoxin malleilactone and are regulated by a genetically linked LuxR-type transcription factor, MalR. Although AHLs typically interact with LuxR-type proteins to modulate gene transcription, the B...
May 7, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29725623/melioidosis-in-thailand-present-and-future
#5
Soawapak Hinjoy, Viriya Hantrakun, Somkid Kongyu, Jedsada Kaewrakmuk, Tri Wangrangsimakul, Siroj Jitsuronk, Weerawut Saengchun, Saithip Bhengsri, Thantapat Akarachotpong, Somsak Thamthitiwat, Ornuma Sangwichian, Siriluck Anunnatsiri, Rasana W Sermswan, Ganjana Lertmemongkolchai, Chayada Sitthidet Tharinjaroen, Kanya Preechasuth, Ratchadaporn Udpaun, Poomin Chuensombut, Nisarat Waranyasirikul, Chanihcha Anudit, Surapong Narenpitak, Yaowaruk Jutrakul, Prapit Teparrukkul, Nittaya Teerawattanasook, Kittisak Thanvisej, Alisa Suphan, Punchawee Sukbut, Kritchavat Ploddi, Poolsri Sirichotirat, Bongkoch Chiewchanyon, Kamolchanok Rukseree, Maliwan Hongsuwan, Gumphol Wongsuwan, Pornpan Sunthornsut, Vanaporn Wuthiekanun, Sandy Sachaphimukh, Prapass Wannapinij, Wirongrong Chierakul, Claire Chewapreecha, Janjira Thaipadungpanit, Narisara Chantratita, Sunee Korbsrisate, Apichai Taunyok, Susanna Dunachie, Prasit Palittapongarnpim, Stitaya Sirisinha, Rungrueng Kitphati, Sopon Iamsirithaworn, Wipada Chaowagul, Ploenchan Chetchotisak, Toni Whistler, Surasakdi Wongratanacheewin, Direk Limmathurotsakul
A recent modelling study estimated that there are 2800 deaths due to melioidosis in Thailand yearly. The Thailand Melioidosis Network (formed in 2012) has been working closely with the Ministry of Public Health (MoPH) to investigate and reduce the burden of this disease. Based on updated data, the incidence of melioidosis is still high in Northeast Thailand. More than 2000 culture-confirmed cases of melioidosis are diagnosed in general hospitals with microbiology laboratories in this region each year. The mortality rate is around 35%...
2018: Tropical Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29720430/evaluation-of-a-rapid-diagnostic-test-for-the-detection-of-burkholderia-pseudomallei-in-the-lao-people-s-democratic-republic
#6
Kate L Woods, Latsaniphone Boutthasavong, Caoimhe NicFhogartaigh, Sue J Lee, Viengmon Davong, David P AuCoin, David A B Dance
Burkholderia pseudomallei causes significant global morbidity and mortality, with the highest disease burden in parts of Asia where culture-based diagnosis is often not available. We prospectively evaluated the Active Melioidosis Detect (AMD, InBios International, USA) lateral flow immunoassay (LFI) for rapid detection of B. pseudomallei in turbid blood cultures, pus, sputum, sterile fluid, urine, and sera. Performance was compared to B. pseudomallei detection using monoclonal antibody latex agglutination (LA) and immunofluorescence assays (IFA), with culture as the gold standard...
May 2, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29706135/de-novo-subgaleal-abscess-a-rare-presentation-of-melioidosis-a-case-report
#7
Chamara Dalugama, Asanka Tennegedara, Indika Bandara Gawarammana
BACKGROUND: Melioidosis is an emerging infection in the tropics caused by the bacterium Burkholderia pseudomallei. Poorly controlled diabetes is a known risk factor. Melioidosis has a broad spectrum of clinical manifestations ranging from a localized abscess to pneumonia to disseminated sepsis with multiorgan failure. Pyrexia of unknown origin is a common presentation. Abscesses in unusual anatomical locations are well known to be associated with melioidosis. CASE PRESENTATION: We report a case of a 64-year-old Sri Lankan Sinhalese man with prolonged fever and constitutional symptoms with a neglected swelling over the back of the scalp who was found to have an abscess in the subgaleal space of the scalp during surgical drainage...
April 30, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29700157/draft-genome-sequence-of-the-first-south-korean-clinical-isolate-of-burkholderia-pseudomallei-h0901
#8
Yong-Woo Shin, Myung-Min Choi, Jeong-Hoon Chun, Jae-Yon Yu, Dae-Won Kim, Gi-Eun Rhie
We report here the draft genome sequence of Burkholderia pseudomallei H0901. This strain was isolated in 2003 from the first melioidosis patient in South Korea.
April 26, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29678218/developing-inclusivity-and-exclusivity-panels-for-testing-diagnostic-and-detection-tools-targeting-burkholderia-pseudomallei-the-causative-agent-of-melioidosis
#9
Charles H D Williamson, David M Wagner, Paul Keim, Jason W Sahl
Background: Diagnostic tools designed to target Burkholderia pseudomallei , the causative agent of melioidosis that was classified as a Tier 1 Select Agent by the U.S. Centers for Disease Control and Prevention, have typically suffered from false-positive and false-negative results because of a lack of understanding of the genomic diversity of B. pseudomallei and its genetic near neighbors. Objective: In this review, we discuss a strategy for using comparative genomics to guide the design of inclusivity and exclusivity panels for the validation of assays as defined by the Standard Method Performance Requirement (SMPR®)...
April 20, 2018: Journal of AOAC International
https://www.readbyqxmd.com/read/29651186/in-vitro-activity-of-doxycycline-and-%C3%AE-lactam-combinations-against-different-strains-of-burkholderia-pseudomallei
#10
Nurul Iman Mohamad, Azian Harun, Habsah Hasan, Zakuan Zainy Deris
Although doxycycline is active against Burkholderia pseudomallei and has been used in the eradication stage of melioidosis therapy, it is not regularly used during the initial intensive phase. In order to assess its potential use in intensive phase therapy, we investigated in vitro pharmacodynamic activity of doxycycline and β-lactams alone and in combination against four Malaysian strains of B. pseudomallei. Using a checkerboard assay, the combinations of doxycycline and imipenem, doxycycline and ceftazidime, and doxycycline and amoxicillin-clavulanate tested against four strains showed indifferent effects with summation fractional inhibitory concentration values ranging from 0...
June 2018: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29623994/clinical-features-and-outcome-of-patients-with-cutaneous-melioidosis-during-a-nosocomial-outbreak-in-a-temperate-region-of-australia
#11
Benjamin Clark, Adam Merritt, Tim Inglis, Laurens Manning
Six cases of cutaneous melioidosis from southwestern Australia, a non-endemic region occurred as a result of Burkholderia pseudomallei contamination of normal saline that was used for irrigating superficial wounds. Treatment with parenteral meropenem, given by continuous infusion for 2 weeks, followed by oral antibiotics was successful in all cases.
April 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29616023/immune-control-of-burkholderia-pseudomallei-common-high-frequency-t-cell-responses-to-a-broad-repertoire-of-immunoprevalent-epitopes
#12
Arnone Nithichanon, Darawan Rinchai, Surachat Buddhisa, Pornpun Saenmuang, Chidchamai Kewcharoenwong, Bianca Kessler, Prasong Khaenam, Ploenchan Chetchotisakd, Bernard Maillere, John Robinson, Catherine J Reynolds, Rosemary J Boyton, Daniel M Altmann, Ganjana Lertmemongkolchai
Burkholderia pseudomallei (Bp) is an environmental bacterial pathogen that causes potentially lethal sepsis in susceptible individuals and is considered a Category B, Tier-1 biothreat agent. As such, it is crucial to gain an improved understanding of protective immunity and potential vaccine candidates. The nature of immune correlates dictating why most exposed individuals in endemic regions undergo asymptomatic seroconversion while others succumb to life-threatening sepsis is largely uncharted. Bp seroreactive, immunogenic proteins have previously been identified by antigen microarray...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29611506/epidemiological-and-clinical-features-of-melioidosis-a-report-of-seven-cases-from-southern-inland-china
#13
Yanping Tang, Jingmin Deng, Jianquan Zhang, Xiaoning Zhong, Ye Qiu, Hui Zhang, Haiguang Xu
Some subtropical regions with similar climatic conditions to melioidosis-endemic areas, such as southern Guangxi, may be new endemic zones for melioidosis. We retrospectively reviewed seven culture-proven melioidosis patients from October 2006 to March 2015. Their clinical characteristics, diagnosis, and treatment, and the geographical and environmental factors were analyzed. Seven male patients lived at latitudes of 21-23°N in Beihai, Nanning, Chongzuo City of the Guangxi Province. Symptom onset occurred during the rainy season...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29611505/hospitalized-bacteremic-melioidosis-in-rural-thailand-2009-2013
#14
Anchalee Jatapai, Christopher J Gregory, Somsak Thamthitiwat, Kittisak Tanwisaid, Saithip Bhengsri, Henry C Baggett, Ornuma Sangwichian, Possawat Jorakate, John R MacArthur
Melioidosis incidence and mortality have reportedly been increasing in endemic areas of Thailand, but little population-based data on culture-confirmed Burkholderia pseudomallei infections exist. We provide updated estimates of melioidosis bacteremia incidence and in-hospital mortality rate using integration of two population-based surveillance databases in Nakhon Phanom, Thailand, since automated blood culture became available in 2005. From 2009 to 2013, 564 hospitalized bacteremic melioidosis patients were identified...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29594800/diagnostic-accuracy-of-the-inbios-amd-rapid-diagnostic-test-for-the-detection-of-burkholderia-pseudomallei-antigen-in-grown-blood-culture-broth
#15
Marjan Peeters, Panha Chung, Hua Lin, Kristien Mortelmans, Chhundy Phe, Chentha San, Laura Maria Francisca Kuijpers, Syna Teav, Thong Phe, Jan Jacobs
To assess the diagnostic and operational performance of the InBiOS AMD rapid diagnostic test (RDT) (Seattle, USA) for the detection of B. pseudomallei in grown blood culture broth. The InBiOS RDT is a lateral flow immunoassay in a strip format detecting B. pseudomallei capsular polysaccharide in culture fluids, marketed for research only. Broth of blood culture bottles (BacT/Alert, bioMérieux, Marcy L'Etoile, France) sampled in adult patients at the Sihanouk Hospital Center of HOPE, Phnom Penh, Cambodia, during 2010-2017 and stored at - 80 °C was tested...
March 28, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29593678/pangenomic-definition-of-prokaryotic-species-and-the-phylogenetic-structure-of-prochlorococcus-spp
#16
Mikhail A Moldovan, Mikhail S Gelfand
The pangenome is the collection of all groups of orthologous genes (OGGs) from a set of genomes. We apply the pangenome analysis to propose a definition of prokaryotic species based on identification of lineage-specific gene sets. While being similar to the classical biological definition based on allele flow, it does not rely on DNA similarity levels and does not require analysis of homologous recombination. Hence this definition is relatively objective and independent of arbitrary thresholds. A systematic analysis of 110 accepted species with the largest numbers of sequenced strains yields results largely consistent with the existing nomenclature...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29579128/performance-evaluation-of-active-melioidosis-detect-lateral-flow-assay-amd-lfa-for-diagnosis-of-melioidosis-in-endemic-settings-with-limited-resources
#17
Tushar Shaw, Chaitanya Tellapragada, Vandana Ke, David P AuCoin, Chiranjay Mukhopadhyay
Melioidosis is a fatal infection caused by the soil saprophyte Burkholderia pseudomallei. Early diagnosis and befitting medical management can significantly influence the clinical outcomes among patients with melioidosis. Witnessing an annual increment in the number of melioidosis cases, over the past few years, mainly from the developing tropical nations, the present study was undertaken to evaluate the diagnostic utility of Active Melioidosis DetectTMLateralFlow Assay (AMD-LFA), in comparison with enrichment culture and PCR...
2018: PloS One
https://www.readbyqxmd.com/read/29579106/impact-of-nutritional-stress-on-drug-susceptibility-and-biofilm-structures-of-burkholderia-pseudomallei-and-burkholderia-thailandensis-grown-in-static-and-microfluidic-systems
#18
Chitchanok Anutrakunchai, Jan G M Bolscher, Bastiaan P Krom, Sakawrat Kanthawong, Sorujsiri Chareonsudjai, Suwimol Taweechaisupapong
Burkholderia pseudomallei is the causative agent of melioidosis and regarded as a bioterrorism threat. It can adapt to the nutrient-limited environment as the bacteria can survive in triple distilled water for 16 years. Moreover, B. pseudomallei exhibits intrinsic resistance to diverse groups of antibiotics in particular while growing in biofilms. Recently, nutrient-limited condition influenced both biofilm formation and ceftazidime (CAZ) tolerance of B. pseudomallei were found. However, there is no information about how nutrient-limitation together with antibiotics used in melioidosis treatment affects the structure of the biofilm produced by B...
2018: PloS One
https://www.readbyqxmd.com/read/29569066/physicochemical-properties-associated-with-the-presence-of-burkholderia-pseudomallei-in-small-ruminant-farm-water-supplies-in-peninsular-malaysia
#19
Hassan Ismail Musa, Latiffah Hassan, Zulkifli Hj Shamsuddin, Chandrawathani Panchadcharam, Zunita Zakaria, Saleha Abdul Aziz
Burkholderia pseudomallei causes melioidosis, a life-threatening infection in both humans and animals. Water is an important reservoir of the bacteria and may serve as a source of environmental contamination leading to infection. B. pseudomallei has an unusual ability to survive in water for a long period. This paper investigates physicochemical properties of water associated with the presence of B. pseudomallei in water supply in small ruminant farms in Peninsular Malaysia. Physicochemical properties of water samples taken from small ruminant farms that included temperature, pH, dissolved oxygen (DO2 ), optical density (OD), and chemical oxygen demand (COD) were measured after which the samples were cultured for B...
March 22, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29563716/influence-of-biochemical-features-of-burkholderia-pseudomallei-strains-on-identification-reliability-by-vitek-2-system
#20
Irina B Zakharova, Yana A Lopasteyskaya, Andrey V Toporkov, Dmitry V Viktorov
Background: Burkholderia pseudomallei is a Gram-negative saprophytic soil bacterium that causes melioidosis, a potentially fatal disease endemic in wet tropical areas. The currently available biochemical identification systems can misidentify some strains of B. pseudomallei . The aim of the present study was to identify the biochemical features of B. pseudomallei , which can affect its correct identification by Vitek 2 system. Materials and Methods: The biochemical patterns of 40 B...
January 2018: Journal of Global Infectious Diseases
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