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https://www.readbyqxmd.com/read/29351056/remediation-of-radiation-induced-cognitive-dysfunction-through-oral-administration-of-the-neuroprotective-compound-nsi-189
#1
Barrett Allen, Munjal M Acharya, Celine Lu, Erich Giedzinski, Nicole Chmielewski, David Quach, Mike Hefferan, Karl K Johe, Charles L Limoli
Clinical management of primary and secondary central nervous system (CNS) malignancies frequently includes radiotherapy to forestall tumor growth and recurrence after surgical resection. While cranial radiotherapy remains beneficial, adult and pediatric brain tumor survivors suffer from a wide range of debilitating and progressive cognitive deficits. Although this has been recognized as a significant problem for decades, there remains no clinical recourse for the unintended neurocognitive sequelae associated with these types of cancer treatments...
January 19, 2018: Radiation Research
https://www.readbyqxmd.com/read/29345192/cross-validation-of-the-dot-counting-test-in-a-large-sample-of-credible-and-non-credible-patients-referred-for-neuropsychological-testing
#2
Courtney McCaul, Kyle B Boone, Annette Ermshar, Maria Cottingham, Tara L Victor, Elizabeth Ziegler, Michelle A Zeller, Matthew Wright
OBJECTIVE: To cross-validate the Dot Counting Test in a large neuropsychological sample. METHOD: Dot Counting Test scores were compared in credible (n = 142) and non-credible (n = 335) neuropsychology referrals. RESULTS: Non-credible patients scored significantly higher than credible patients on all Dot Counting Test scores. While the original E-score cut-off of ≥17 achieved excellent specificity (96.5%), it was associated with mediocre sensitivity (52...
January 18, 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29343837/neurocognitive-dysfunction-in-hematopoietic-cell-transplant-recipients-expert-review-from-the-late-effects-and-quality-of-life-working-committee-of-the-cibmtr-and-complications-and-quality-of-life-working-party-of-the-ebmt
#3
REVIEW
David Buchbinder, Debra Lynch Kelly, Rafael F Duarte, Jeffery J Auletta, Neel Bhatt, Michael Byrne, Zachariah DeFilipp, Melissa Gabriel, Anuj Mahindra, Maxim Norkin, Helene Schoemans, Ami J Shah, Ibrahim Ahmed, Yoshiko Atsuta, Grzegorz W Basak, Sara Beattie, Sita Bhella, Christopher Bredeson, Nancy Bunin, Jignesh Dalal, Andrew Daly, James Gajewski, Robert Peter Gale, John Galvin, Mehdi Hamadani, Robert J Hayashi, Kehinde Adekola, Jason Law, Catherine J Lee, Jane Liesveld, Adriana K Malone, Arnon Nagler, Seema Naik, Taiga Nishihori, Susan K Parsons, Angela Scherwath, Hannah-Lise Schofield, Robert Soiffer, Jeff Szer, Ida Twist, Anne B Warwick, Baldeep M Wirk, Jean Yi, Minoo Battiwalla, Mary D E Flowers, Bipin Savani, Bronwen E Shaw
Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and non-malignant diseases. Despite increasing survival rates, long-term morbidity following HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction following HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction following HCT...
January 17, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29336125/association-of-chronic-subjective-tinnitus-with-neuro-cognitive-performance
#4
Sunita Gudwani, Sanjay K Munjal, Naresh K Panda, Adarsh Kohli
INTRODUCTION: Chronic subjective tinnitus is associated with cognitive disruptions affecting perception, thinking, language, reasoning, problem solving, memory, visual tasks (reading) and attention. OBJECTIVE: To evaluate existence of any association between tinnitus parameters and neuropsychological performance to explain cognitive processing. MATERIALS AND METHODS: Study design was prospective, consisting 25 patients with idiopathic chronic subjective tinnitus and gave informed consent before planning their treatment...
December 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/29332467/is-hippocampal-avoidance-during-whole-brain-radiotherapy-risky-for-patients-with-small-cell-lung-cancer-hippocampal-metastasis-rate-and-associated-risk-factors
#5
Esra Korkmaz Kirakli, Ozgur Oztekin
OBJECTIVES: Hippocampal avoidance during whole-brain radiotherapy is performed to prevent neural stem cell injury causing neurocognitive dysfunction. Nevertheless, the estimated risk of metastases in hippocampal avoidance area in small-cell lung cancer is unknown. The current study aimed to characterize the metastatic distribution within the brain relative to the hippocampus, estimate the incidence of hippocampal metastasis in patients with small-cell lung cancer, and identify clinical and radiographic variables that may be associated with the risk of hippocampal avoidance area metastasis...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29331931/resting-state-fmri-signals-in-offspring-of-parents-with-bipolar-disorder-at-the-high-risk-and-ultra-high-risk-stages-and-their-relations-with-cognitive-function
#6
Kangguang Lin, Robin Shao, Rui Lu, Kun Chen, Weicong Lu, Ting Li, Jiehua Kong, Kwok-Fai So, Guiyun Xu
BACKGROUND: Bipolar disorder (BD) has been associated with dysfunctional resting-state brain functioning. However, it is still not known whether the aberrant functioning occurs and predict cognitive functioning before illness onset. AIMS: We examined the resting-state regional and network dysfunctioning, and their correlates with neurocognitive performance, in the high-risk (HR) and ultra-high-risk (UHR) stages of bipolar disorder. METHODS: Using amplitude of low-frequency fluctuations (ALFF), region homogeneity (ReHo) and hypothesis-driven region-of-interest (ROI)-based connectivity, we examined resting-state fMRI data of 8- to 25-year-old healthy offspring (HR, n = 28) and offspring with subthreshold syndromes (UHR, n = 22) of a BD parent, and age-matched healthy controls without any personal or family psychopathology (HC, n = 46)...
January 8, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29331600/a-real-world-study-on-the-genetic-cognitive-and-psychopathological-differences-of-obese-patients-clustered-according-to-eating-behaviours
#7
Mariarita Caroleo, Amedeo Primerano, Marianna Rania, Matteo Aloi, Valentina Pugliese, Fabio Magliocco, Gilda Fazia, Andrea Filippo, Flora Sinopoli, Marco Ricchio, Franco Arturi, Susana Jimenez-Murcia, Fernando Fernandez-Aranda, Pasquale De Fazio, Cristina Segura-Garcia
BACKGROUND: Considering that specific genetic profiles, psychopathological conditions and neurobiological systems underlie human behaviours, the phenotypic differentiation of obese patients according to eating behaviours should be investigated. The aim of this study was to classify obese patients according to their eating behaviours and to compare these clusters in regard to psychopathology, personality traits, neurocognitive patterns and genetic profiles. METHODS: A total of 201 obese outpatients seeking weight reduction treatment underwent a dietetic visit, psychological and psychiatric assessment and genotyping for SCL6A2 polymorphisms...
December 14, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29330881/cocaine-and-hiv-1-tat-disrupt-cholesterol-homeostasis-in-astrocytes-implications-for-hiv-associated-neurocognitive-disorders-in-cocaine-user-patients
#8
Bianca Cotto, Kalimuthusamy Natarajaseenivasan, Kimberly Ferrero, Leroy Wesley, Matthew Sayre, Dianne Langford
Cholesterol synthesis and clearance by astrocytes are tightly regulated to maintain constant levels within the brain. In this context, liver X receptors (LXRs) are the master regulators of cholesterol homeostasis in the central nervous system (CNS). Increasing levels of cholesterol in astrocytes trigger LXR activation leading to the transcription of target genes involved in cholesterol trafficking and efflux, including apolipoprotein E, cytochrome P450 enzymes, sterol regulatory binding protein, and several ATP-binding cassette transporter proteins...
January 13, 2018: Glia
https://www.readbyqxmd.com/read/29330372/non-estrogenic-xanthohumol-derivatives-mitigate-insulin-resistance-and-cognitive-impairment-in-high-fat-diet-induced-obese-mice
#9
Cristobal L Miranda, Lance A Johnson, Oriane de Montgolfier, Valerie D Elias, Lea S Ullrich, Joshua J Hay, Ines L Paraiso, Jaewoo Choi, Ralph L Reed, Johana S Revel, Chrissa Kioussi, Gerd Bobe, Urszula T Iwaniec, Russell T Turner, Benita S Katzenellenbogen, John A Katzenellenbogen, Paul R Blakemore, Adrian F Gombart, Claudia S Maier, Jacob Raber, Jan F Stevens
Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic syndrome (MetS). However, its metabolic transformation into the estrogenic metabolite, 8-prenylnaringenin (8-PN), poses a potential health concern for its use in humans. To address this concern, we evaluated two hydrogenated derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), which showed negligible affinity for estrogen receptors α and β, and which cannot be metabolically converted into 8-PN...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320916/the-reliability-of-the-montreal-cognitive-assessment-using-telehealth-in-a-rural-setting-with-veterans
#10
Nathaniel DeYoung, Brian V Shenal
Background Telehealth neuropsychological services can increase the availability of specialised care for individuals in rural areas where barriers to these services are faced. As this practice becomes more commonplace, the reliability and validity of neuropsychological assessment administered by telehealth continues to be established. The Montreal Cognitive Assessment, a screener for general neurocognitive dysfunction, may be particularly useful since this measure can be given by telehealth with minimal adaptation...
January 1, 2018: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29316520/psychosocial-functioning-in-patients-with-psychotic-and-non-psychotic-bipolar-i-disorder-a-comparative-study-with-individuals-with-schizophrenia
#11
Estela Jiménez-López, Eva María Sánchez-Morla, Ana Isabel Aparicio, Ana López-Villarreal, Vicente Martínez-Vizcaíno, Roberto Rodriguez-Jimenez, Eduard Vieta, José Luis Santos
BACKGROUND: More than 50% of individuals with bipolar disorder (BD) do not reach full psychosocial functioning, even during periods of euthymia. It has been suggested that history of psychotic symptoms is one of the factors which are associated with a worse functional outcome. The objective was to compare psychosocial functioning between patients with BD, with (BD-P), and without (BD-NP) a history of psychotic symptoms, and to examine whether the history of psychotic symptoms, or other clinical or neurocognitive variables predict psychosocial functioning...
January 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29306521/what-can-autism-teach-us-about-the-role-of-sensorimotor-systems-in-higher-cognition-new-clues-from-studies-on-language-action-semantics-and-abstract-emotional-concept-processing
#12
REVIEW
Rachel L Moseley, Friedemann Pulvermüller
Within the neurocognitive literature there is much debate about the role of the motor system in language, social communication and conceptual processing. We suggest, here, that autism spectrum conditions (ASC) may afford an excellent test case for investigating and evaluating contemporary neurocognitive models, most notably a neurobiological theory of action perception integration where widely-distributed cell assemblies linking neurons in action and perceptual brain regions act as the building blocks of many higher cognitive functions...
December 7, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29302261/how-to-approach-feeding-difficulties-in-young-children
#13
REVIEW
Hye Ran Yang
Feeding is an interaction between a child and caregiver, and feeding difficulty is an umbrella term encompassing all feeding problems, regardless of etiology, severity, or consequences, while feeding disorder refers to an inability or refusal to eat sufficient quantities or variety of food to maintain adequate nutritional status, leading to substantial consequences, including malnutrition, impaired growth, and possible neurocognitive dysfunction. There are 6 representative feeding disorder subtypes in young children: infantile anorexia, sensory food aversion, reciprocity, posttraumatic type, state regulation, and feeding disorders associated with concurrent medical conditions...
December 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29300226/intervention-program-to-improve-executive-functions-and-enhance-planning-abilities-of-patients-with-mild-neurocognitive-disorder
#14
Daisuke Fukuta, Chizuru Mori
PURPOSE: The aim of this study was to examine the effects of an intervention program to improve executive functions and enhance the planning abilities of patients with mild neurocognitive disorder. DESIGN: A pilot intervention study. METHODS: Ten inpatients performed an intervention program based on Lezak's conceptual model that teaches task-specific routines. The program consisted of six training sessions presented over a 2-week period. Neuropsychological assessments were performed pre- and postintervention...
January 3, 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29287782/naringenin-induced-enhanced-antioxidant-defence-system-meliorates-cholinergic-neurotransmission-and-consolidates-memory-in-male-rats
#15
Laraib Liaquat, Zehra Batool, Sadia Sadir, Sahar Rafiq, SidrahShahzad, Tahira Perveen, Saida Haider
AIMS: Free radical mediated neurotoxicity is a leading cause of neurodegenerative disorders. Neurodegeneration due to oxidative stress can produce cognitive dysfunctions. Flavonoids and curcuminoids are naturally occurring polyphenolic compounds that display a variety of therapeutic importance against oxidative stress. MAIN METHODS: This study was designed to assess potential role of polyphenolic compounds in neurocognitive functions and prevention against oxidative stress...
December 26, 2017: Life Sciences
https://www.readbyqxmd.com/read/29286496/evoked-bioelectrical-brain-activity-following-exposure-to-ionizing-radiation
#16
K Loganovsky, K Kuts
The article provides an overview of modern physiological evidence to support the hypothesis on cortico limbic sys tem dysfunction due to the hippocampal neurogenesis impairment as a basis of the brain interhemispheric asym metry and neurocognitive deficit after radiation exposure. The importance of the research of both evoked poten tials and fields as a highly sensitive and informative method is emphasized.Particular attention is paid to cerebral sensor systems dysfunction as a typical effect of ionizing radiation...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29282326/neurocognitive-functioning-and-cerebrovascular-reactivity-after-carotid-endarterectomy
#17
Simona Lattanzi, Luciano Carbonari, Gabriele Pagliariccio, Marco Bartolini, Claudia Cagnetti, Giovanna Viticchi, Laura Buratti, Leandro Provinciali, Mauro Silvestrini
OBJECTIVE: To evaluate in patients with TIA and ipsilateral high-grade internal carotid artery (ICA) stenosis whether changes in cognitive performance and cerebral hemodynamics occurred after carotid endarterectomy (CEA) and to explore their relationship. METHODS: Participants were patients who underwent CEA, had TIA within the last 6 months, and had an ipsilateral severe ICA stenosis. Coloured Progressive Matrices (CPM) plus Complex Figure Copy Test (CFCT) and phonemic (ph) plus categorical (ca) Verbal Fluency (VF) tests were performed to assess right and left hemisphere cognitive functions, respectively...
December 27, 2017: Neurology
https://www.readbyqxmd.com/read/29278998/neurocognitive-and-fine-motor-deficits-in-asymptomatic-adolescents-during-the-subacute-period-after-concussion
#18
Richard J Servatius, Kevin M Spiegler, Justin D Handy, Kevin C H Pang, Jack W Tsao, Catherine A Mazzola
Adolescents are at high risk for sustaining concussions. There is considerable controversy regarding the sensitivity of neurocognitive tests to detect and track dysfunction in the aftermath of concussion. Two neurocognitive test batteries were compared during the subacute phase of recovery from concussion to determine sensitivity to concussion. Adolescents (ages 11-17 years) with a concussion diagnosis (8 males, 7 females, 9-69 days after injury) were recruited through a concussion clinic and compared to community non-concussed volunteers (11 males, 3 females)...
December 26, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29260041/cognitive-functions-in-newly-diagnosed-patients-with-hiv-infection-in-a-tertiary-health-facility-assessment-using-community-screening-interview-for-dementia
#19
T A Sumonu, F Imarhiagbe, L F Owolabi, O A Ogunrin, M A Komolafe, O S Ilesanmi
Introduction: Neurocognitive dysfunction is a detrimental complication of HIV infection. In this study we attempt to characterize the pattern of cognitive dysfunction in a sample of Nigerian patients with newly diagnosed HIV infection. Methods: We conducted a prospective study in which 50 patients with newly diagnosed HIV infection were studied along with 50 normal control subjects. The participants were evaluated with the medical history, general, physical and neurological examination...
December 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29250027/derivation-of-a-three-biomarker-panel-to-improve-diagnosis-in-patients-with-mild-traumatic-brain-injury
#20
W Frank Peacock, Timothy E Van Meter, Nazanin Mirshahi, Kyle Ferber, Robert Gerwien, Vani Rao, Haris Iqbal Sair, Ramon Diaz-Arrastia, Frederick K Korley
Background: Nearly 5 million emergency department (ED) visits for head injury occur each year in the United States, of which <10% of patients show abnormal computed tomography (CT) findings. CT negative patients frequently suffer protracted somatic, behavioral, and neurocognitive dysfunction. Our goal was to evaluate biomarkers to identify mild TBI (mTBI) in patients with suspected head injury. Methods: An observational ED study of head-injured and control patients was conducted at Johns Hopkins University (HeadSMART)...
2017: Frontiers in Neurology
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