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https://www.readbyqxmd.com/read/29917324/effects-of-h1-antihistamine-addition-to-intranasal-corticosteroid-for-allergic-rhinitis-a-systematic-review-and-meta-analysis
#1
REVIEW
Kachorn Seresirikachorn, Wirach Chitsuthipakorn, Dichapong Kanjanawasee, Likhit Khattiyawittayakun, Kornkiat Snidvongs
BACKGROUND: A combination of H1 antihistamine (AH) with intranasal corticosteroid (INCS) is commonly prescribed to patients with allergic rhinitis (AR) who have an inadequate response to monotherapy. In this systematic review we aimed to determine the effects of AH combined with INCS (AH-INCS) for treating AR. METHODS: Literature searches were performed using Medline and Embase. Randomized, controlled trials that studied the effects of AH-INCS vs INCS monotherapy for treating patients with AR were included...
June 19, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29917249/exposure-to-hypoglycemia-and-risk-of-stroke
#2
REVIEW
Logan Smith, Diya Chakraborty, Pallab Bhattacharya, Deepaneeta Sarmah, Sebastian Koch, Kunjan R Dave
In the treatment of both type 1 and type 2 diabetes mellitus, maintaining a euglycemic state represents one of the key challenges. Improper dosing and administration of glucose-lowering drugs is associated with an increased risk of recurrent hypoglycemia episodes. In addition, the risk of adverse cardiovascular events in diabetic patients, particularly myocardial infarctions and strokes, is well established. Current research indicates a potential link between the baseline risk of cardio/cerebrovascular events in diabetic patients and exposure to hypoglycemia...
June 19, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29917242/mechanoadaptation-articular-cartilage-through-thick-and-thin
#3
Tonia L Vincent, Angus Wann
The articular cartilage is exquisitely sensitive to mechanical load. Its structure is largely defined by the mechanical environment and destruction in osteoarthritis is the pathophysiological consequence of abnormal mechanics. It is often overlooked that disuse of joints causes profound loss of volume in the articular cartilage, a clinical observation first described in polio patients and stroke victims. Through the 1980s, the results of studies exploiting experimental joint immobilisation supported this. Importantly, this substantial body of work was also the first to describe metabolic changes that resulted in decreased synthesis of matrix molecules, especially sulfated proteoglycans...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917225/psychological-treatments-for-adults-and-children-with-epilepsy-evidence-based-recommendations-by-the-international-league-against-epilepsy-psychology-task-force
#4
Rosa Michaelis, Venus Tang, Laura H Goldstein, Markus Reuber, William Curt LaFrance, Tobias Lundgren, Avani C Modi, Janelle L Wagner
Given the significant impact that psychosocial factors and epilepsy treatments can have on the health-related quality of life (HRQOL) of individuals with epilepsy and their families, there is great clinical interest in the role of psychological evaluation and treatments to improve HRQOL and comorbidities. Therefore, the International League Against Epilepsy (ILAE) charged the Psychology Task Force with the development of recommendations for clinical care based on evaluation of the evidence from their recent Cochrane review of psychological treatments in individuals with epilepsy...
June 19, 2018: Epilepsia
https://www.readbyqxmd.com/read/29917197/crispr-technology-new-paradigm-to-target-the-infectious-disease-pathogens
#5
M A Bakhrebah, M S Nassar, M S Alsuabeyl, W A Zaher, S A Meo
OBJECTIVE: Infectious diseases are one of the prime causes of death worldwide. An innovative sequence specific editing technology "Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)" has been tested on a broad range of microorganisms to target and destroy invading foreign DNA to human cells or tissues. This study aimed to discuss the mechanism and therapeutic usage of CRISPR/Cas9 genome editing technology in the management of various infectious disease pathogens...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917160/the-relationship-between-healthcare-workers-attachment-styles-and-patient-outcomes-a-systematic-review
#6
Chizu Mimura, Ian J Norman
Purpose: To examine whether attachment styles of healthcare workers influence the quality of their relationships with patients, or impact patients' health outcomes. Data source: Literature database searches on the CINAHL, Cochrane Library, Embase, MEDLINE and PsyCinfo, and hand searching of reference lists of the retained articles. Study selection: Original empirical studies reporting an analysis of the relationship of interest were selected for review...
June 1, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29917092/systematic-review-and-meta-analysis-of-controlled-intervention-studies-on-the-effectiveness-of-long-chain-omega-3-fatty-acids-in-patients-with-nonalcoholic-fatty-liver-disease
#7
Kathy Musa-Veloso, Carolina Venditti, Han Youl Lee, Maryse Darch, Seth Floyd, Spencer West, Ryan Simon
Context: Treatment options for nonalcoholic fatty liver disease (NAFLD) are needed. Objective: The aim of this review was to systematically assess the effects of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs), particularly eicosapentaenoic acid and docosahexaenoic acid, on liver-related and metabolic outcomes in adult and pediatric patients with NAFLD. Data Sources: The online information service ProQuest Dialog was used to search 8 literature databases...
June 15, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29917011/pigmented-villonodular-synovitis-of-the-knee-an-underappreciated-source-of-pain-in-children-and-adolescents
#8
Samuel Clifton Willimon, Michael T Busch, Crystal A Perkins
BACKGROUND: Pigmented villonodular synovitis (PVNS) is a benign proliferative synovial disorder most commonly described in adults. The purpose of this study is to describe the presentation and management of a large single-center series of pediatric patients with PVNS of the knee. METHODS: A retrospective review was performed of consecutive pediatric patients treated for PVNS at a single institution from 2001 to 2016. Inclusion criteria were patients below 20 years of age with surgical treatment of histologically proven PVNS of the knee...
June 18, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29916983/mandibular-reconstruction-for-pediatric-patients
#9
Loreto Castellon, Daniel Jerez, Jaime Mayorga, Alejandra Gallego, Carlos Fuenzalida, German Laissle
: Mandibular reconstruction in pediatric patients is controversial. The scant pediatric experience and the infrequent occurrence of this type of pathology in children complicate therapeutic decisions. The literature contains different treatment protocols and describes the bone graft alternatives to be used. MATERIALS AND METHOD: This is a retrospective review of patients under the age of 15 who were subjected to resection and reconstruction. RESULTS: A total of 18 patients were included in the study: 8 women and 10 men...
June 18, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29916970/optimal-timing-of-alveolar-cleft-bone-grafting-for-maxillary-clefts-in-the-cleft-palate-population
#10
Arminder S Kaura, Dhivya R Srinivasa, Steven J Kasten
PURPOSE: Timing of bone grafting for maxillary alveolar clefts is not standardized. Secondary bone grafting is often performed; however, consensus does not exist regarding use of chronologic versus dental age to guide treatment. Several authors suggest an early chronologic age is associated with greater success. Available literature was systematically reviewed for evidence for optimal timing for grafting maxillary alveolar clefts. METHODS: PubMed, MEDLINE, and Cochrane Central Registrar of Controlled Trials databases were queried for manuscripts pertaining to maxillary alveolar cleft bone grafting...
June 18, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29916858/nonalcoholic-fatty-liver-disease-and-hypertension-coprevalent-or-corelated
#11
Dimitrios Oikonomou, Georgios Georgiopoulos, Vassiliki Katsi, Chris Kourek, Constantinos Tsioufis, Alexendra Alexopoulou, Evaggelia Koutli, Dimitrios Tousoulis
OBJECTIVE: To provide a comprehensive review summarizing the existing evidence on the association between nonalcoholic fatty liver disease (NAFLD) and hypertension (HT) independent of other components of metabolic syndrome. METHODS: We searched the literature through Medline and the Cochrane Library for studies evaluating the relationship between hypertension and fatty liver disease. RESULTS: Studies testing this association are limited, but agree that HT and fatty liver disease are inter-related independent of other components of the metabolic syndrome such as obesity and diabetes mellitus...
June 18, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29916847/haploinsufficiency-of-a20-and-other-paediatric-inflammatory-disorders-with-mucosal-involvement
#12
Florence A Aeschlimann, Ronald M Laxer
PURPOSE OF REVIEW: This review aims at summarizing the current knowledge of A20 haploinsufficiency and other paediatric inflammatory disorders with mucosal involvement. RECENT FINDINGS: A20 haploinsufficiency is a newly described autoinflammatory disease caused by loss-of-function mutations in TNFAIP3 that result in the activation of the nuclear factor (NF)-kB pathway. Patients may present with dominantly inherited, early-onset systemic inflammation and a Beh├žet-like disease, or a variety of autoinflammatory and autoimmune features...
June 16, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29916843/towards-a-framework-for-reporting-self-guided-interventions-for-people-with-cancer
#13
Anna Ugalde, Nicole Kiss, Patricia Livingston, Sanchia Aranda
PURPOSE OF REVIEW: The purpose of this article is to provide an updated review exploring the recent developments in the field of self-guided interventions and describe the state of knowledge. This article builds on a previous systematic review on self-guided interventions, finding that the recent literature demonstrates that evidence for these interventions is mixed. The field is limited by descriptions of these interventions, and it is not possible to ascertain what aspects of interventions are more successful...
June 18, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29916840/developments-in-the-treatment-of-benign-essential-blepharospasm
#14
Michael T Yen
PURPOSE OF REVIEW: To review new developments in the medical and surgical treatment options for benign essential blepharospasm (BEB). RECENT FINDINGS: Botulinum toxin injections remain the mainstay treatment for BEB with several formulations currently commercially available. Reports in the medical literature support photochromatic modulation for the symptoms of photophobia, as well as oral medications and surgical myectomy for control of the motor signs of eyelid protractor spasm...
June 18, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29916835/the-modern-cardiovascular-care-unit-the-cardiologist-managing-multiorgan-dysfunction
#15
Thomas Bochaton, Eric Bonnefoy-Cudraz, Nadia Aissaoui
PURPOSE OF REVIEW: Despite many advances in the management of critically ill patients, cardiogenic shock remains a challenge because it is associated with high mortality. Even if there is no universally accepted definition of cardiogenic shock, end-perfusion organ dysfunction is an obligatory and major criterion of its definition.Organ dysfunction is an indicator that cardiogenic shock is already at an advanced stage and is undergoing a rapid self-aggravating evolution. The aim of the review is to highlight the importance to diagnose and to manage the organ dysfunction occurring in the cardiogenic shock patients by providing the best literature published this year...
June 16, 2018: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29916834/letter-can-islamic-jurisprudence-justify-procurement-of-transplantable-vital-organs-in-brain-death
#16
Mohamed Y Rady
In their article, "An International Legal Review of the Relationship between Brain Death and Organ Transplantation," in The Journal of Clinical Ethics 29, no. 1, Aramesh, Arima, Gardiner, and Shah reported on diverse international legislative approaches for justifying procurement of transplantable vital organs in brain death. They stated, "In Islamic traditions in particular, the notion of unstable life is a way to justify organ donation from brain-dead patients that we believe has not been fully described previously in the literature...
2018: Journal of Clinical Ethics
https://www.readbyqxmd.com/read/29916829/action-guide-for-addressing-ethical-challenges-of-resource-allocation-within-community-based-healthcare-organizations
#17
Krista L Harrison, Holly A Taylor, Maria W Merritt
This article proposes an action guide to making decisions regarding the ethical allocation of resources that affect access to healthcare services offered by community-based healthcare organizations. Using the filter of empirical data from a study of decision making in two community-based healthcare organizations, we identify potentially relevant conceptual guidance from a review of frameworks and action guides in the public health, health policy, and organizational ethics literature. We describe the development of this action guide...
2018: Journal of Clinical Ethics
https://www.readbyqxmd.com/read/29916808/evaluation-and-management-strategies-for-per-and-polyfluoroalkyl-substances-pfass-in-drinking-water-aquifers-perspectives-from-impacted-u-s-northeast-communities
#18
Jennifer L Guelfo, Thomas Marlow, David M Klein, David A Savitz, Scott Frickel, Michelle Crimi, Eric M Suuberg
BACKGROUND: Multiple Northeast U.S. communities have discovered per- and polyfluoroalkyl substances (PFASs) in drinking water aquifers in excess of health-based regulatory levels or advisories. Regional stakeholders (consultants, regulators, and others) need technical background and tools to mitigate risks associated with exposure to PFAS-affected groundwater. OBJECTIVES: The aim was to identify challenges faced by stakeholders to extend best practices to other regions experiencing PFAS releases and to establish a framework for research strategies and best management practices...
June 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29916776/acute-appendicitis-a-meta-analysis-of-the-diagnostic-accuracy-of-us-ct-and-mri-as-second-line-imaging-tests-after-an-initial-us
#19
Kevin A Eng, Aryan Abadeh, Carolina Ligocki, Yvonne K Lee, Rahim Moineddin, Thomasin Adams-Webber, Suzanne Schuh, Andrea S Doria
Purpose To evaluate the sensitivity, specificity, and diagnostic odds ratios of US, CT, and MRI as second-line imaging modalities after initial US for assessing acute appendicitis in children and adults. Materials and Methods A literature search was conducted in Medline and Embase to identify articles that used surgery or histopathologic examination alone or in combination with clinical follow-up or chart review to evaluate the diagnostic accuracy of second-line imaging modalities. The quality of articles was assessed by using the Quality Assessment of Diagnostic Accuracy Studies-2 and the Standards for Reporting of Diagnostic Accuracy tools...
June 19, 2018: Radiology
https://www.readbyqxmd.com/read/29916740/preserving-skin-integrity-with-chronic-device-use-in-diabetes
#20
Laurel H Messer, Cari Berget, Christie Beatson, Sarit Polsky, Gregory P Forlenza
Skin integrity and diabetes device placement are ongoing concerns for people with diabetes who utilize continuous glucose monitors (CGMs) and continuous subcutaneous insulin infusion pumps. This is especially significant for individuals with skin sensitivities, pediatric patients, and those who use devices chronically. Dermatological complications are often cited as a barrier to device use and a reason for device discontinuation. Furthermore, it is a frequent topic of discussion in diabetes follow-up visits, although little evidence-based literature exists to guide providers in managing skin integrity issues...
June 2018: Diabetes Technology & Therapeutics
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