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https://www.readbyqxmd.com/read/29332099/association-between-the-intron-8-vntr-polymorphism-of-the-dat1-gene-and-crack-cocaine-addiction
#1
Anderson R Stolf, Diana Müller, Jaqueline B Schuch, Gláucia C Akutagava-Martins, Luciano S P Guimaraes, Claudia M Szobot, Ricardo Halpern, Felix H P Kessler, Flavio Pechansky, Tatiana Roman
BACKGROUND: This study aims to compare allele and genotype frequencies of a 30-bp variable number of tandem repeats (VNTR) polymorphism of the DAT1 gene, located at intron 8, between adult crack cocaine users and nonaddicted individuals. Due to its involvement in drug addiction, this gene is a good candidate for molecular studies. METHODS: A cross-sectional sample of 239 current adult crack abusers or dependents from in- and outpatient clinics and 211 control individuals was collected in Brazil...
January 12, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29308644/near-infrared-fluorescent-nanoprobes-for-revealing-the-role-of-dopamine-in-drug-addiction
#2
Peijian Feng, Yulei Chen, Lei Zhang, Cheng-Gen Qian, Xuanzhong Xiao, Xu Han, Qun-Dong Shen
Brain imaging techniques enable visualizing the activity of central nervous system without invasive neurosurgery. Dopamine is an important neurotransmitter. Its fluctuation in brain leads to a wide range of diseases and disorders, like drug addiction, depression, and Parkinson disease. We designed near-infrared fluorescence dopamine-responsive nanoprobes (DRNs) for brain activity imaging during drug abuse and addiction process. Based on light-induced electron transfer between DRNs and dopamine and molecular wire effect of the DRNs, we can track dynamical change of the neurotransmitter level in the physiological environment and the releasing of the neurotransmitter in living dopaminergic neurons in response to nicotine stimulation...
January 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29307544/role-of-mglu7-receptor-in-morphine-rewarding-effects-is-uncovered-by-a-novel-orthosteric-agonist
#3
Zuzana Hajasova, Corinne Canestrelli, Francine Acher, Florence Noble, Nicolas Marie
Opiate dependence is a major health issue and despite the existence of opioid substitution treatment, relapse frequently occurs. Group III metabotropic glutamate (mGlu) receptors has received much attention as a putative target in ethanol and cocaine addiction, but no data on opiate addiction exist. So we investigated the role of group III mGlu receptor in morphine rewarding effects through the expression and the reinstatement of conditioned place preference (CPP) using a newly synthesized mGlu4/mGlu7 receptor orthosteric agonist, LSP2-9166...
January 4, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29301614/metabotropic-glutamate-receptors-2-and-3-as-targets-for-treating-nicotine-addiction
#4
REVIEW
Alan J Cross, Robert Anthenelli, Xia Li
Tobacco smoking, driven by the addictive properties of nicotine, continues to be a worldwide health problem. Based on the well-established role of glutamatergic neurotransmission in drug addiction, novel medication development strategies seek to halt nicotine consumption and prevent relapse to tobacco smoking by modulating glutamate transmission. The presynaptic inhibitory metabotropic glutamate receptors 2 and 3 (mGluR2/3) are key autoreceptors on glutamatergic terminals that maintain glutamate homeostasis...
November 21, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29295020/disclosing-sex-trading-histories-to-providers-barriers-and-facilitators-to-navigation-of-social-services-among-women-impacted-by-commercial-sexual-exploitation
#5
Lara Gerassi, Tonya E Edmond, Vanessa Fabbre, Abby Howard, Andrea J Nichols
Sex trafficking and commercial sexual exploitation (CSE) can lead to devastating health and mental health consequences for women, such as elevated rates of substance use, trauma, posttraumatic stress disorder, depression, sexually transmitted infections (STIs), and HIV. Consequently, engagement with services that address addiction, mental health, and housing, and provide general advocacy is critically important to women's increased safety, stabilization, and quality of life. The purpose of this study is to identify perceived barriers and facilitators to service access and engagement with social services among women involved in CSE...
December 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29287237/a-novel-approach-of-substitution-therapy-with-inhalation-of-essential-oil-for-the-reduction-of-inhalant-craving-a-double-blinded-randomized-controlled-trial
#6
Rasmon Kalayasiri, Wanjaree Maneesang, Michael Maes
Inhalants, which are neurotoxic central nervous system (CNS) suppressants, are frequently abused by young adults. Unlike other CNS depressants, including alcohol and opiates, no treatment is currently approved for inhalant dependence. In this report, a novel approach of substitution treatment for inhalant addiction was explored in a double-blinded, randomized, controlled crossover design to examine the effects of inhalation of essential oil and perfume on the reduction of cue-induced craving for inhalant in thirty-four Thai males with inhalant dependence...
December 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29280617/synaptic-plasticity-in-the-nucleus-accumbens-lessons-learned-from-experience
#7
Brandon D Turner, Daniel T Kashima, Kevin M Manz, Carrie A Grueter, Brad A Grueter
Synaptic plasticity contributes to behavioral adaptations. As a key node in the reward pathway, the nucleus accumbens (NAc) is important for determining motivation-to-action outcomes. Thus, the NAc is a model system to elucidate mechanisms underlying behavioral plasticity at the synaptic level. Across animal models of motivation including addiction, depression, anxiety, and hedonic feeding, selective recruitment of neuromodulatory signals and plasticity mechanisms have been a focus of physiologists and behaviorists alike...
December 27, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29280394/insomnia-partially-mediated-the-association-between-problematic-internet-use-and-depression-among-secondary-school-students-in-china
#8
Ji-Bin Li, Joseph T F Lau, Phoenix K H Mo, Xue-Fen Su, Jie Tang, Zu-Guo Qin, Danielle L Gross
Background and aims This study aims to examine the mediating effects of insomnia on the associations between problematic Internet use, including Internet addiction (IA) and online social networking addiction (OSNA), and depression among adolescents. Methods A total of 1,015 secondary school students from Guangzhou in China participated in a cross-sectional survey. Levels of depression, insomnia, IA, and OSNA were assessed using the Center for Epidemiological Studies-Depression Scale, Pittsburgh Sleep Quality Index, Young's Diagnostic Questionnaire, and Online Social Networking Addiction Scale, respectively...
December 1, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29280393/internet-gaming-disorder-and-online-gambling-disorder-clinical-and-personality-correlates
#9
Nuria Mallorquí-Bagué, Fernando Fernández-Aranda, María Lozano-Madrid, Roser Granero, Gemma Mestre-Bach, Marta Baño, Amparo Del Pino-Gutiérrez, Mónica Gómez-Peña, Neus Aymamí, José M Menchón, Susana Jiménez-Murcia
Background and aims The recent growth of Internet use has led to an increase of potentially problematic behaviors that can be engaged online, such as online gambling or Internet gaming. The aim of this study is to better conceptualize Internet gaming disorder (IGD) by comparing it with gambling disorder (GD) patients who only gamble online (online GD). Methods A total of 288 adult patients (261 online GD and 27 IGD) completed self-reported questionnaires for exploring psychopathological symptoms, food addiction (FA), and personality traits...
December 1, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29280392/comorbidity-of-internet-use-disorder-and-attention-deficit-hyperactivity-disorder-two-adult-case-control-studies
#10
Martin Bielefeld, Marion Drews, Inken Putzig, Laura Bottel, Toni Steinbüchel, Jan Dieris-Hirche, Gregor R Szycik, Astrid Müller, Mandy Roy, Martin Ohlmeier, Bert Theodor Te Wildt
Objectives There is good scientific evidence that attention deficit hyperactivity disorder (ADHD) is both a predictor and a comorbidity of addictive disorders in adulthood. These associations not only focus on substance-related addictions but also on behavioral addictions like gambling disorder and Internet use disorder (IUD). For IUD, systematic reviews have identified ADHD as one of the most prevalent comorbidities besides depressive and anxiety disorders. Yet, there is a need to further understand the connections between both disorders to derive implications for specific treatment and prevention...
December 1, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29275839/the-multifaceted-role-of-the-ventromedial-prefrontal-cortex-in-emotion-decision-making-social-cognition-and-psychopathology
#11
REVIEW
Jaryd Hiser, Michael Koenigs
The ventromedial prefrontal cortex (vmPFC) has been implicated in a variety of social, cognitive, and affective functions that are commonly disrupted in mental illness. In this review, we summarize data from a diverse array of human and animal studies demonstrating that the vmPFC is a key node of cortical and subcortical networks that subserve at least three broad domains of psychological function linked to psychopathology. One track of research indicates that the vmPFC is critical for the representation of reward- and value-based decision making, through interactions with the ventral striatum and amygdala...
November 20, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29240823/facebook-addiction-disorder-fad-among-german-students-a-longitudinal-approach
#12
Julia Brailovskaia, Jürgen Margraf
The present study aimed to investigate Facebook Addiction Disorder (FAD) in a German student sample over a period of one year. While mean FAD level did not increase during the investigation period, a significant increase was shown in the number of participants reaching the critical cutoff score. FAD was significantly positively related to the personality trait narcissism and to negative mental health variables (depression, anxiety, and stress symptoms). Furthermore, FAD fully mediated the significant positive relationship between narcissism and stress symptoms, which demonstrates that narcissistic people can be specifically at risk to develop FAD...
2017: PloS One
https://www.readbyqxmd.com/read/29238271/dual-depression-a-sex-perspective
#13
Adriana Farré, Judit Tirado-Muñoz, Marta Torrens
Mood and substance use disorders (SUDs) are mental conditions that are highly prevalent in the general population. Cooccurrence of major depression and SUD, also known as dual depression, is very common in the field of substance addiction. Sex differences are found in both major depression and SUD. This review, after presenting the state of the art of dual depression as regards prevalence, ethiopathologic mechanisms, and clinical aspects, is focused on dual depression in women. An overview of some potential factors associated with the sex gap in dual depression such as injecting, sexual risk behavior, intimate partner violence, and the reproductive cycle is presented...
December 2017: Addictive Disorders & Their Treatment
https://www.readbyqxmd.com/read/29231146/comparison-of-two-naloxone-regimens-in-addicted-methadone-overdosed-patients-a-clinical-trial-study
#14
Navid Khosravi, Nasim Zamani, Hossein Hassanian-Moghaddam, Ali Ostadi, Mitra Rahimi, Ali Kabir
BACKGROUND: Methadone toxicity is one of the major causes of death in opioid dependent individuals. OBJECTIVE: We aimed to compare two different protocols for naloxone in terms of reversal of overdose and frequency of complications in opioid-dependent methadone-intoxicated patients. METHODS: One-hundred opioid-dependent patients with signs/symptoms of methadone overdose were included. The patients were consecutively assigned into Tintinalli (group 1) or Goldfrank regimen protocol (group 2) of naloxone administration...
December 11, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29227790/interpersonal-and-intrapersonal-emotional-processes-in-individuals-treated-for-alcohol-use-disorder-and-non-addicted-healthy-individuals
#15
Maciej Kopera, Elisa M Trucco, Andrzej Jakubczyk, Hubert Suszek, Aneta Michalska, Aleksandra Majewska, Natalia Szejko, Agata Łoczewska, Aleksandra Krasowska, Anna Klimkiewicz, Kirk J Brower, Robert A Zucker, Marcin Wojnar
INTRODUCTION: Prior work largely confirms the presence of various emotional processing deficits among individuals with an alcohol use disorder (AUD); however, their specificity and relevance still warrant investigation. The aim of the current study was to compare selected aspects of emotional processing (i.e., mental state recognition, alexithymia, and emotional intelligence) between individuals treated for an AUD and healthy individuals. METHODS: The AUD sample consisted of 92 abstinent men with AUD who were participating in an 8-week inpatient abstinence-based treatment program in Warsaw, Poland...
December 5, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29223143/neurobiological-functions-of-the-period-circadian-clock-2-gene-per2
#16
REVIEW
Mikyung Kim, June Bryan de la Peña, Jae Hoon Cheong, Hee Jin Kim
Most organisms have adapted to a circadian rhythm that follows a roughly 24-hour cycle, which is modulated by both internal (clock-related genes) and external (environment) factors. In such organisms, the central nervous system (CNS) is influenced by the circadian rhythm of individual cells. Furthermore, the period circadian clock 2 (Per2) gene is an important component of the circadian clock, which modulates the circadian rhythm. Per2 is mainly expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as other brain areas, including the midbrain and forebrain...
December 8, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29216892/opiate-agonist-treatment-to-improve-health-of-individuals-with-opioid-use-disorder-in-lebanon
#17
Ali Ghaddar, Zeinab Abbas, Ramzi Haddad
BACKGROUND: Opioid agonist therapy has been widely used to reduce harms among individuals with opioid use disorder but its effectiveness has not been evaluated in the Middle East North African (MENA) region. This study aims to evaluate the effectiveness of a program using opioid agonist therapy in combination with psychosocial support on improving psychological and social well-being, reducing arrest, and reducing risky behavior in individuals with opioid use disorder in Lebanon. METHODS: A one-group pre-test post-test design study was performed at SKOUN Lebanese Addiction Centre between January 2013 and December 2014...
December 8, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/29214825/effects-of-pride-and-regret-on-geriatric-depression-a-cross-cultural-study-with-mixed-methods-approaches
#18
Othelia E Lee, Seungah Ryu
Pride and regret are self-conscious emotions that develop later in life and become a source of emotional struggle. This cross-cultural study examined the effect of the content and intensity of self-conscious emotions on Geriatric Depression Scale (GDS) scores. Among a convenience sample of 234 older adults (130 in the United States and 104 in South Korea), the contents and intensities of both life regrets and pride were examined. Although a greater variety of regrets was cited by Americans, overall Korean respondents reported higher intensity of regret...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/29209395/prevalence-and-psychiatric-comorbidities-of-internet-addiction-in-a-nationwide-sample-of-korean-adults
#19
Subin Park, Hong Jin Jeon, Jae Nam Bae, Su Jeong Seong, Jin Pyo Hong
The goal of the study was to examine the prevalence and psychiatric comorbidities of Internet addiction in a nationwide sample of Korean adults. Among a total of 6,022 participants involved in Korean Epidemiological Catchment Area study in 2011, 3,723 Internet users were assessed for their Internet addiction using Young's 8-item Diagnostic Questionnaire. The results showed that of the 3,723 Internet users, 39 (1.0%) had Internet addiction. Addicted Internet users were younger, more likely to be males and unemployed compared to non-addicted Internet users...
November 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29209393/relationship-between-problematic-internet-use-and-post-traumatic-stress-disorder-symptoms-among-students-following-the-sewol-ferry-disaster-in-south-korea
#20
Ju-Yeon Lee, Sung-Wan Kim, Hee-Ju Kang, Seon-Young Kim, Kyung-Yeol Bae, Jae-Min Kim, Il-Seon Shin, Jin-Sang Yoon
We investigated the association between problematic internet use (PIU) and post-traumatic stress disorder (PTSD) symptoms in children and adolescents in South Korea. A cross-sectional survey was administered to community students who attended primary, secondary, and high schools in the Jindo area 1-2.5 months after the Sewol ferry disaster. Of the 1,744 respondents, 392 students who were exposed to the disaster, witnessing the rescue work directly, were evaluated. PTSD symptoms were measured using the University of California Los Angeles Post-traumatic Stress Disorder Reaction Index (UCLA PTSD-RI)...
November 2017: Psychiatry Investigation
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