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https://www.readbyqxmd.com/read/29147165/outcomes-of-popliteal-to-distal-bypass-combined-with-femoropopliteal-artery-endovascular-treatment-for-critical-limb-ischemia
#1
Yoshihiko Tsuji, Ikuro Kitano, Koji Sugimoto
Objective: The aim of this study was to evaluate outcomes of combined popliteal-to-distal bypass and endovascular treatment (EVT) for femoropopliteal lesions in patients with critical limb ischemia (CLI). Patients and Methods: We reviewed data of 14 CLI patients who were treated by popliteal-to-distal bypass combined with femoropopliteal EVT. The femoropopliteal lesions included 3 TASC II-A, 8 TASC II-B, and 3TASC II-C but no TASC II-D, and balloon dilatation was performed in 9 cases and a stent was placed in 5 cases...
September 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29036714/accounting-for-technical-noise-in-differential-expression-analysis-of-single-cell-rna-sequencing-data
#2
Cheng Jia, Yu Hu, Derek Kelly, Junhyong Kim, Mingyao Li, Nancy R Zhang
Recent technological breakthroughs have made it possible to measure RNA expression at the single-cell level, thus paving the way for exploring expression heterogeneity among individual cells. Current single-cell RNA sequencing (scRNA-seq) protocols are complex and introduce technical biases that vary across cells, which can bias downstream analysis without proper adjustment. To account for cell-to-cell technical differences, we propose a statistical framework, TASC (Toolkit for Analysis of Single Cell RNA-seq), an empirical Bayes approach to reliably model the cell-specific dropout rates and amplification bias by use of external RNA spike-ins...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28978866/two-year-clinical-outcomes-post-implantation-of-epic-tm-self-expanding-nitinol-stents-for-the-aortoiliac-occlusive-disease-in-patients-with-peripheral-arterial-disease
#3
Takuya Tsujimura, Osamu Iida, Masashi Fujita, Masaharu Masuda, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takashi Kanda, Shota Okuno, Yasuhiro Matsuda, Masahiko Fujihara, Yoshiaki Yokoi, Toshiaki Mano
AIM: We investigated 2-year clinical outcomes after implantaton of Epic(TM) self-expanding nitinol stents for patients with peripheral artery disease (PAD) due to the aortoiliac occlusive disease (AIOD). METHODS: This study was a multicenter and retrospective study. From February 2013 through October 2014, 292 lesions (chronic total occlusion, 21%; TASC Ⅱ C/D, 35%) in 217 consecutive patients (74±8 years; male, 81%; diabetes mellitus, 47%; dialysis, 21%; critical limb ischemia, 29%) who had undergone endovascular therapy (EVT) with Epic(TM) self-expanding nitinol stents for PAD with AIOD were analyzed...
October 5, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28943491/comparison-of-endovascular-versus-bypass-surgery-in-femoropopliteal-tasc-ii-d-lesions-a-single-center-study
#4
Gian Franco Veraldi, Luca Mezzetto, Marco Macrì, Paolo Criscenti, Arianna Corvasce, Ranieri Poli
BACKGROUND: In patients with severe occlusive disease (Trans-Atlantic Inter-Society Consensus II D [TASC II D]) of the femoropopliteal segment, the advantages of endovascular versus bypass revascularization still remain debated. Most reports available in literature comparing percutaneous transluminal angioplasty (PTA) ± bare metal stent (BMS) versus synthetic bypass analyze patients with heterogeneous anatomical lesions creating possible bias when results of different treatments are matched...
September 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28933521/the-use-of-covered-stents-in-aortoiliac-obstructions-a-systematic-review-and-meta-analysis-of-the-literature
#5
Joost A Bekken, Hidde Jongsma, Bram Fioole
BACKGROUND: During the past decade, endovascular treatment has become the treatment of choice for all types of aortoiliac occlusive disease, including TASC C and D lesions. Patency rates, however, are still below those of open surgical techniques. One propagated technique to improve patency rates is the use of covered stents. This review assessed the available literature on covered stents for aortoiliac occlusive disease. METHODS: An extensive search was performed of the MEDLINE, Embase, and Cochrane databases...
September 20, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28931471/endovascular-treatment-of-iliac-and-common-femoral-arteries-disease-by-the-transradial-access-a-prospective-feasibility-study
#6
Roberto Lorenzoni, Cristiano Lisi, Giulia Lorenzoni, Laura Tessandori, Francesco Bovenzi
AIM: To report feasibility and safety of endovascular interventions on iliac and common femoral arteries, using the transradial access (TRA). METHODS: 100 consecutive patients (19 women; mean age 71, range 37-90years) with critical limb ischemia (30%) or claudication, and TASC A-D lesions in iliac or common femoral arteries, were prospectively enrolled, from January 2013 to June 2015, to be treated via the TRA. Exclusion criteria included no palpable radial arteries (RA) and the presence of a fistula for hemodialysis...
August 18, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28893701/impact-of-vascular-calcifications-on-long-femoropopliteal-stenting-outcomes
#7
Adrien Kaladji, Pierre-Alexandre Vent, Aurore Danvin, Philippe Chaillou, Alain Costargent, Béatrice Guyomarch, Thibaut Quillard, Yann Gouëffic
OBJECTIVE: Vascular calcifications (VCs) may be a prognostic factor for outcome after endovascular treatment of peripheral arterial disease (PAD). Semi-quantitative analysis with X-ray imaging is the main limiting factor for assessing VCs. The aim of the present study was to find a correlation between the amount of VC with a CT scan quantification and mid-term results of endovascular treatment of TASC C/D femoropopliteal (FP) lesions. METHODS: Patients belonging to two previously published registries (STELLA and STELLA PTX) and who underwent a preoperative CT scan were retrospectively included in the study...
September 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28891375/results-of-afx-unibody-stent-graft-implantation-in-patients-with-tasc-d-aortoiliac-lesions-and-coexistent-abdominal-aortic-aneurysms
#8
Pasqualino Sirignano, Wassim Mansour, Laura Capoccia, Chiara Pranteda, Nunzio Montelione, Francesco Speziale
PURPOSE: To describe results of AFX unibody stent-graft treatment for TransAtlantic Inter-Society Consensus (TASC) D aortoiliac occlusive disease (AIOD) with coexistent abdominal aortic aneurysm (AAA). METHODS: A retrospective analysis was conducted of 21 consecutive patients (mean age 73.6±6.4 years; 17 men) with TASC D AIOD plus AAA (diameter >3.5 cm) treated electively using the AFX stent-graft. Common iliac artery (CIA) and external iliac artery (EIA) stenosis or occlusion was reported...
September 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28890068/is-the-endovascular-treatment-of-mild-iliac-stenoses-worthwhile-to-improve-wound-healing-in-patients-undergoing-femorotibial-bypass
#9
Paolo Sapienza, Luigi Venturini, Raffaele Grande, Valerio Scarano Catanzaro, Sergio Gazzanelli, Antonio V Sterpetti, Elvira Tartaglia
BACKGROUND: After an infrapopliteal reconstruction, minor amputations are frequently required, but even in the case of successful revascularization, wound healing is a major concern. We studied the role of iliac artery inflow correction in patients undergoing infrapopliteal vein grafts to improve the heal of midfoot amputation. METHODS: Thirty-eight patients affected with Rutherford grade III category 5 peripheral arterial disease, who underwent successful simultaneous iliac endovascular procedure, infrapopliteal reversed vein bypass graft, and minor amputation, were enrolled in this retrospective study...
September 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28887251/metabolic-syndrome-but-not-obesity-adversely-affects-outcomes-after-open-aortoiliac-bypass-surgery
#10
Akiko Tanaka, Alexa Perlick, Charles C Miller, Harleen K Sandhu, Shaikh Afaq, Hazim J Safi, Ali Azizzadeh, Kristofer M Charlton-Ouw
OBJECTIVE: Although the incident risk of peripheral artery disease increases in patients with metabolic syndrome, several authors report favorable outcomes in obese patients after arterial bypass surgery. We examine the effect of the so-called "obesity paradox" and metabolic syndrome on outcomes after open aortoiliac bypass surgery. METHODS: We identified patients between 2004 and 2015 who had open surgical bypass for aortoiliac occlusive disease. We excluded patients with endovascular repair and those treated primarily for aneurysmal disease...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28872035/prevalence-and-severity-of-peripheral-arterial-disease-among-patient-with-heel-pressure-ulcer-a-retrospective-study-of-42-patients
#11
Guillaume Tisserand, Nora Zenati, Christophe Seinturier, Sophie Blaise, Gilles Pernod
Heel pressure ulcer is a major complication in elderly hospitalized patients. The association with peripheral arterial disease (PAD) which is also a frequent disease in this population is poorly known. The aim of this study was to assess the prevalence of PAD and critical limb ischemia (CLI) in patients with heel pressure ulcer. Patients referred to the vascular medicine department for heel pressure ulcer from October 2014 to June 2015 were included in the study. The assessment of peripheral arterial disease was made with the results of ankle brachial index and/or doppler ultra sound of lower limb arteries...
September 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28854856/first-clinical-experience-with-the-multi-loc-multiple-stent-delivery-system-for-focal-stenting-in-long-femoro-popliteal-lesions
#12
Klaus Amendt, Ulrich Beschorner, Matthias Waliszewski, Martin Sigl, Ralf Langhoff, Jörg Thalwitzer, Ulf Redlich, Britta Vogel, Dirk Härtel, Thomas Zeller
Background: The purpose of this observational study is to report the six-month clinical outcomes with a new multiple stent delivery system in patients with femoro-popliteal lesions. Patients and methods: The LOCOMOTIVE study is an observational multicentre study with a primary endpoint target lesion revascularization (TLR) rate at six months. Femoro-popliteal lesions were prepared with uncoated and/or paclitaxel-coated peripheral balloon catheters. When flow limiting dissections, elastic recoil or recoil due to calcification required stenting, up to six short stents per delivery device, each 13 mm in length, were implanted...
August 31, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28828514/morphological-characteristics-of-chronic-total-occlusion-predictors-of-different-strategies-for-long-segment-femoral-arterial-occlusions
#13
Li-Ming Wei, Yue-Qi Zhu, Pei-Lei Zhang, Fang Liu, Hai-Tao Lu, Jun-Gong Zhao
OBJECTIVES: To investigate morphological characteristics used to predict recanalisation strategies in long-segment (>10 cm) femoral chronic total occlusion (LSF-CTO) angioplasty. METHODS: We retrospectively evaluated a range of morphological CTA and DSA features in patients who underwent recanalisation of LSF-CTO. The stage of CTO was classified into early (3-12 months) and late (>12 months) according to estimated duration. Characteristics including stump morphology, lesion length and calcification, proximal side branches, collaterals circulation, runoff vessels and concomitant arterial occlusion were used as predictors, and multivariate logistic regression analysis was performed to identify variables associated with late-stage CTO and retrograde technique...
August 21, 2017: European Radiology
https://www.readbyqxmd.com/read/28818667/endoconduits-with-pave-and-crack-technique-avoid-open-ilio-femoral-conduits-with-sustainable-mid-term-results
#14
G Asciutto, M Aronici, T Resch, B Sonesson, T Kristmundsson, N V Dias
OBJECTIVE/BACKGROUND: The objective was to evaluate the feasibility and mid-term outcomes of endoconduits (EC) with the "pave and crack" technique during endovascular aneurysm repair (EVAR) of varying complexity. METHODS: This was a retrospective study. All patients undergoing EC between July 2009 and October 2015 were included. The primary endpoint was technical success of the EC defined as the ability to successfully deliver the aortic stent graft through the EC without rupture, dissection, or thrombosis of the iliac or femoral arteries, and with the absence of haemodynamically significant blood loss related to the EC...
October 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28774866/outcomes-of-infrapopliteal-angioplasty-for-limb-salvage-based-on-the-updated-tasc-ii-classification
#15
Hong Kuan Kok, Hamed Asadi, Mark Sheehan, Frank P McGrath, Mark F Given, Michael J Lee
PURPOSE: We aimed to evaluate limb salvage, defined as freedom from major amputation, and to identify predictors of major amputation in patients with infrapopliteal peripheral arterial disease (PAD) based on the updated 2015 TASC II anatomic classification treated by percutaneous transluminal angioplasty (PTA). METHODS: This was a retrospective study of infrapopliteal PTA procedures performed for PAD over a 4-year period. Patient demographics, medical comorbidities, risk factors, angiographic imaging, technical details, and clinical follow-up were analyzed to determine limb salvage rates, technical success, and all-cause mortality...
September 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28765738/baseline-characteristics-of-a-retrospective-patient-cohort-in-the-korean-vascular-intervention-society-endovascular-therapy-in-lower-limb-artery-diseases-k-vis-ella-registry
#16
Young-Guk Ko, Chul-Min Ahn, Pil-Ki Min, Jae-Hwan Lee, Chang-Hwan Yoon, Cheol Woong Yu, Seung Whan Lee, Sang-Rok Lee, Seung Hyuk Choi, Yoon Seok Koh, In-Ho Chae, Donghoon Choi
BACKGROUND AND OBJECTIVES: The Korean Vascular Intervention Society Endovascular Therapy in Lower Limb Artery Diseases (K-VIS ELLA) Registry is a multicenter observational study with retrospective and prospective cohorts of patients with lower extremity peripheral artery disease (PAD) undergoing endovascular treatment. In this study, we report the baseline characteristics of this retrospective cohort. SUBJECTS AND METHODS: In the present study we analyzed datasets of 3073 patients with 3972 target limbs from a retrospective cohort treated with endovascular therapy in 31 Korean hospitals...
July 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28763728/crural-index-and-extensive-atherosclerosis-of-crural-vessels-are-associated-with-long-term-cardiovascular-mortality-in-patients-with-symptomatic-peripheral-artery-disease
#17
Jan-Erik Wickström, Juho M Jalkanen, Maarit Venermo, Harri H Hakovirta
BACKGROUND AND AIMS: Limited data exist on the association of the anatomical distribution of atherosclerotic lesions and the extent of atherosclerosis at defined arterial segments with life expectancy. We recently presented a new classification of the extent of atherosclerosis in crural vessels and showed that Crural Index (CIx) was associated with mid-term survival of symptomatic peripheral artery disease (PAD) patients. This study evaluates the significance of the extent of crural atherosclerosis on long-term cardiovascular mortality...
July 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28747061/endovascular-treatment-for-steno-occlusive-iliac-artery-disease-safety-and-long-term-outcome
#18
Arne M Müller, Nicolas Langwieser, Christian Bradaric, Bernhard Haller, Massimiliano Fusaro, Ilka Ott, Nicolas von Beckerath, Adnan Kastrati, Karl-Ludwig Laugwitz, Tareq Ibrahim
We evaluated safety and long-term outcome of endovascular therapy for steno-occlusive iliac artery disease. All endovascular procedures of iliac artery lesions performed at our institution between 2001 and 2014 (n = 676) were retrospectively analyzed. The overall technical success rate was 99% and yielded 100% for stenoses (n = 596) and 95% for chronic total occlusions (n = 80). Lesion complexity defined by the Trans-Atlantic Inter-Society Consensus (TASC) II classification had no impact on success rates (TASC A + B vs C + D; 99...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28705338/-femoropopliteal-angioplasty-short-and-mid-term-results
#19
M Ben Hammamia, M Ben Mrad, B Derbel, R Miri, J Ziadi, F Ghedira, R Denguir, T Kalfat
BACKGROUND: Percutaneous endovascular therapy is becoming a primary option for managing femoropopliteal occlusive disease. The purpose of this study was to evaluate the mid-term results of endovascular treatment of femoropopliteal arterial disease. METHODS: Femoropopliteal percutaneous transluminal angioplasty was performed on 162 consecutive limbs (160 patients) from January 2006 to January 2016. RESULTS: In our study, 87.6% of patients had critical limb ischemia...
July 2017: J Med Vasc
https://www.readbyqxmd.com/read/28697693/pivotal-study-of-a-next-generation-balloon-expandable-stent-graft-for-treatment-of-iliac-occlusive-disease
#20
Jean Bismuth, Bruce H Gray, Andrew Holden, Christopher Metzger, Jean Panneton
PURPOSE: To evaluate the safety and efficacy of a next-generation balloon-expandable stent-graft for the treatment of arterial occlusive disease in patients with de novo or restenotic lesions in the common and/or external iliac arteries. METHODS: A prospective, multicenter, single-arm safety and efficacy study ( ClinicalTrials.gov identifier: NCT02080871) of the VBX Stent Graft for treatment of de novo or restenotic lesions in the iliac arteries was conducted under an Investigational Device Exemption at 26 US sites and 1 New Zealand center...
October 2017: Journal of Endovascular Therapy
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