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Haneen T Salah, Richard K Yang, Sinchita Roy-Chowdhuri, Merrick I Ross, Phyu P Aung, Aimi T Rothrock, Carlos A Torres-Cabala, Jonathan L Curry, Victor G Prieto, Priyadharsini Nagarajan, Woo Cheal Cho
ALK-fused Spitz melanocytic neoplasms are a distinct subgroup of melanocytic lesions exhibiting unique histopathologic characteristics. These lesions often manifest as exophytic or polypoid tumors, characterized by fusiform-to-epithelioid melanocytes arranged in a nested, fascicular, or plexiform growth pattern. Several fusion partners of the ALK gene have been identified in spitzoid melanocytic neoplasms, with TPM3 and DCTN1 being the most prevalent. Less common fusion partners include NPM1, TPR, CLIP1, GTF3C2, EEF2, MYO5A, KANK1, and EHBP1...
March 5, 2024: Journal of Cutaneous Pathology
#22
JOURNAL ARTICLE
Yazid K Ghanem, Armaun D Rouhi, Ammr Al-Houssan, Zena Saleh, Matthew C Moccia, Hansa Joshi, Kristoffel R Dumon, Young Hong, Francis Spitz, Amit R Joshi, Michael Kwiatt
INTRODUCTION: Generative artificial intelligence (AI) chatbots have recently been posited as potential sources of online medical information for patients making medical decisions. Existing online patient-oriented medical information has repeatedly been shown to be of variable quality and difficult readability. Therefore, we sought to evaluate the content and quality of AI-generated medical information on acute appendicitis. METHODS: A modified DISCERN assessment tool, comprising 16 distinct criteria each scored on a 5-point Likert scale (score range 16-80), was used to assess AI-generated content...
March 5, 2024: Surgical Endoscopy
#23
JOURNAL ARTICLE
Pattamon Sutthatarn, Andrew M Davidoff, Armita Bahrami, Celine Richard, Bhatia Shalini, Teresa C Santiago, Barry L Shulkin, Alberto S Pappo, Abdelhafeez Abdelhafeez
PURPOSE: To assess the prognostic and therapeutic significance of sentinel lymph node biopsy (SLNB) and completion lymph node dissection (CLND) in pediatric conventional melanoma (CM), while evaluating potential predictive factors for outcomes. METHODS: We conducted a retrospective analysis of medical records spanning 2009-2020, focusing on patients aged 18 or younger with localized cutaneous conventional melanoma. RESULTS: Among the 33 patients, SLNB detected metastasis in 57...
March 5, 2024: Pediatric Surgery International
#24
JOURNAL ARTICLE
Emi Dika, Martina Lambertini, Federico Venturi, Giulia Veronesi, Simona Mastroeni, Bor Hrvatin Stancic, Aleksandra Bergant-Suhodolcan
Spitz tumors are a subset of melanocytic neoplasms characterized by epithelioid or spindled melanocytes(1). The benign nature of the "Spitz nevus" has since been clarified, but the debate regarding Spitzoidtumors (STs) is still ongoing. Spitzoid tumors encompass a wide spectrum of cutaneous lesions ranging from benign Spitz nevus (SN) to Spitzoid melanoma (SM), the latter displaying capacity for widespread metastasis and a potentially lethal outcome (2). The term atypical Spitz tumors (ASTs) refers to melanocytic tumors exhibiting the morphological features of SN, as well as some features associated with malignancy, but not sufficient to classify them as SMs...
December 2023: Acta Dermatovenerologica Croatica: ADC
#25
JOURNAL ARTICLE
Mohit Khera, Helen L Bernie, Gregory Broderick, Serge Carrier, Martha Faraday, Tobias Kohler, Lawrence Jenkins, Daniel Watter, John Mulhall, Omer Raheem, Ranjith Ramasamy, Rachel Rubin, Aaron Spitz, Faysal Yafi, Hossein Sadeghi-Nejad
PURPOSE: The purpose of this white paper is to educate health care professionals about the evolution of telemedicine (TM) and to propose a hybrid model that leverages the strengths of traditional in-person medicine as well as virtual medicine while maximizing the safety and quality of men's sexual health care. LITERATURE SEARCH STRATEGY: A literature search focused on the use of TM in urology and men's health was performed through PubMed/MEDLINE, Embase, and Web of Science (January 1, 2012-April 26, 2022)...
February 28, 2024: Journal of Sexual Medicine
#26
JOURNAL ARTICLE
William B Hammert, Jun Seob Song, Yujiro Yamada, Ryo Kataoka, Vickie Wong, Robert W Spitz, Aldo Seffrin, Anna Kang, Jeremy P Loenneke
We sought to determine the effects of blood flow restriction (BFR) on exercise-induced hypoalgesia, specifically using low-load (LL) resistance exercise (30% 1RM) protocols that accounted for each individual's local muscular endurance capabilities. Forty-four participants completed four conditions: (1) 70% of maximal BFR repetitions with blood flow restriction (LL+BFR exercise); (2) 70% maximal BFR repetitions without LL+BFR (LL exercise); (3) 70% maximal free flow repetitions (LL+EFFORT exercise); (4) time-matched, non-exercise control (CON)...
February 27, 2024: Journal of Sports Sciences
#27
JOURNAL ARTICLE
Irene Moysset, Natalia Castrejon, Adriana Garcia-Herrera, Paola Castillo, Marta Marginet, Cristina Teixido, Sebastian Podlipnik, Raquel Albero-Gonzalez, Carla Montironi, Judit Navarro, Carlota Rovira, Susana Puig, Cristina Carrera, Llucia Alos
AIMS: The current WHO classification of melanocytic tumours excludes neoplasms showing BRAF or NRAS mutations from the Spitz category. This study aimed to review and reclassify atypical melanocytic tumours with spitzoid morphological features diagnosed between 2009 and 2021 in our hospital after expanding the molecular profile, including BRAF and NRAS mutations in all cases. METHODS AND RESULTS: A total of 71 neoplasms showing spitzoid features (Spitz-like) and atypia were included...
February 26, 2024: Histopathology
#28
REVIEW
Kyriakos Chatzopoulos, Antonia Syrnioti, Konstantinos Linos
Over the last 75 years, our understanding of Spitz lesions has undergone substantial evolution. Initially considered a specific type of melanoma, the perception has shifted towards recognizing Spitz lesions as a spectrum comprising Spitz nevi, Spitz melanocytomas, and Spitz melanomas. Spitz lesions are known for posing a significant diagnostic challenge regarding the distinction between benign neoplasms displaying atypical traits and melanomas. A comprehensive understanding of their molecular basis and genomic aberrations has significantly improved precision in classifying and diagnosing these challenging lesions...
January 31, 2024: Genes
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JOURNAL ARTICLE
Mekhla Singhania, Amira Zaher, Casey F Pulliam, Khaliunaa Bayanbold, Charles C Searby, Joshua D Schoenfeld, Kranti A Mapuskar, Melissa A Fath, Bryan G Allen, Douglas R Spitz, Michael S Petronek
Cancer cells frequently present elevated intracellular iron levels, which are thought to facilitate an enhanced proliferative capacity. Targeting iron metabolism within cancer cells presents an avenue to enhance therapeutic responses, necessitating the use of non-invasive models to modulate iron manipulation to predict responses. Moreover, the ubiquitous nature of iron necessitates the development of unique, non-invasive markers of metabolic disruptions to develop more personalized approaches and enhance the clinical utility of these approaches...
February 18, 2024: International Journal of Molecular Sciences
#30
JOURNAL ARTICLE
Samuel R Bunting, Nitin Vidyasagar, Neeral K Sheth, Raunak S Khisty, Deborah Spitz
OBJECTIVE: The present study examines trends of percent of applicants, number of specialties, and specialty combinations for psychiatry residency applicants applying to multiple specialties (parallel application). METHODS: The authors conducted a retrospective analysis of data captured by the Association of American Medical Colleges Electronic Residency Application System for applicants to psychiatry residency between 2009 and 2021. The percent parallel-applying, the mean number of specialties, mean application counts, and frequency of specialty combinations with psychiatry residency were determined...
April 2024: Academic Psychiatry
#31
JOURNAL ARTICLE
Amira Zaher, Bryce Duchman, Marina Ivanovic, Douglas R Spitz, Muhammad Furqan, Bryan G Allen, Michael S Petronek
BACKGROUND: Radiation therapy (RT) is an integral and commonly used therapeutic modality for primary lung cancer. However, radiation-induced lung injury (RILI) limits the irradiation dose used in the lung and is a significant source of morbidity. Disruptions in iron metabolism have been linked to radiation injury, but the underlying mechanisms remain unclear. PURPOSE: To utilize a targeted radiation delivery approach to induce RILI for the development of a model system to study the role of radiation-induced iron accumulation in RILI...
February 14, 2024: Bioengineering
#32
REVIEW
Maged Daruish, Francesca Ambrogio, Anna Colagrande, Andrea Marzullo, Rita Alaggio, Irma Trilli, Giuseppe Ingravallo, Gerardo Cazzato
In recent years, particular interest has developed in molecular biology applied to the field of dermatopathology, with a focus on nevi of the Spitz spectrum. From 2014 onwards, an increasing number of papers have been published to classify, stratify, and correctly frame molecular alterations, including kinase fusions. In this paper, we try to synthesize the knowledge gained in this area so far. In December 2023, we searched Medline and Scopus for case reports and case series, narrative and systematic reviews, meta-analyses, observational studies-either longitudinal or historical, case series, and case reports published in English in the last 15 years using the keywords spitzoid neoplasms, kinase fusions, ALK, ROS1, NTRK (1-2-3), MET, RET, MAP3K8, and RAF1...
February 14, 2024: Dermatopathology (Basel, Switzerland)
#33
REVIEW
Adhya Mehta, Jared Spitz, Sneha Sharma, Jason Bonomo, LaPrincess C Brewer, Laxmi S Mehta, Garima Sharma
Cardiovascular diseases (CVD) remain the number one cause of maternal mortality, with over two-thirds of the cases being preventable. Social determinants of health (SDoH) encompass the non-medical social and environmental factors that an individual experiences which have a significant impact on their health. These stressors disproportionately affect socially disadvantaged and minority populations. Pregnancy is a physiologically stressful state that can unmask underlying CVD risk factors and lead to adverse pregnancy outcomes (APOs)...
February 20, 2024: Canadian Journal of Cardiology
#34
Mehrdad Mashhadi, Vahid Ganjiani, Amin Bigham-Sadegh, Amir-Hossein Shafiee
A 2-year-old Pomeranian-Spitz dog (5.8 kg) was admitted with symptoms of uterine prolapse and lethargy 1 day after whelping three puppies. The prolapsed uterus was corrected, but the next day, prolapse reoccurred. To fix the cervix to the abdominal wall, the dog underwent a surgery operation where intussusception in the left horn of the uterus was found. Ovariohysterectomy was performed as the treatment of choice. The diagnosis of intussusception is challenging, and exploratory laparotomy is the reliable diagnostic approach...
March 2024: Veterinary Medicine and Science
#35
JOURNAL ARTICLE
Jesús Machuca-Aguado, Cecilia Iborra García-Trevijano, Carmen Orrego-Pereira, Ana María Montaña-Ramírez, Juan José Ríos-Martín
No abstract text is available yet for this article.
February 7, 2024: American Journal of Dermatopathology
#36
JOURNAL ARTICLE
Viktor Laurin Sedlmayr, Silvia Schobesberger, Sarah Spitz, Peter Ertl, David Johannes Wurm, Julian Quehenberger, Oliver Spadiut
Neutral and positively charged archaeal ether lipids (AEL) have been studied for their utilization as novel delivery systems for pDNA, showing efficient immune response with a strong memory effect while lacking noticeable toxicity. Recent technological advances placed mRNA lipid nanoparticles (LNPs) at the forefront of next-generation delivery systems; however, no study has examined AELs in mRNA delivery yet. In this study, we investigated either a crude lipid extract or the purified tetraether lipid caldarchaeol from Sulfolobus acidocaldarius as potential novel excipients for mRNA LNPs...
February 10, 2024: European Journal of Pharmaceutics and Biopharmaceutics
#37
REVIEW
Fortunato Cassalia, Andrea Danese, Ina Tudurachi, Serena Federico, Anna Zambello, Alessia Guidotti, Ludovica Franceschin, Anna Bolzon, Luigi Naldi, Anna Belloni Fortina
Preferentially Expressed Antigen in Melanoma (PRAME), a member of the cancer/testis antigen family, is central to the field of skin cancer diagnostics and therapeutics. As a nuclear receptor and transcriptional regulator, PRAME plays a critical role in inhibiting retinoic acid signalling, which is essential for cell differentiation and proliferation. Its aberrant overexpression in various malignancies, particularly cutaneous melanoma, is associated with more aggressive tumour phenotypes, positioning PRAME as both a diagnostic and prognostic marker...
January 27, 2024: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Carmen Cantisani, Giovanni Paolino, Antonio Di Guardo, Vito Gomes, Andrea Carugno, Maria Elisabetta Greco, Noah Musolff, Giulia Azzella, Giovanni Rossi, Giuseppe Soda, Caterina Longo, Giovanni Pellacani
Background: Agmination and/or satellitosis in pigmented blue lesions is a phenomenon rarely mentioned in the literature and not well known. This phenomenon can be expressed by several benign and malignant pigmented blue lesions, such as blue nevi, Spitz nevi, melanocytoma and melanoma. On this spectrum, dermoscopy, reflectance confocal microscopy (RCM) and dynamic Optical coherence tomography (D-OCT) represent non-invasive imaging technologies, which may help clinicians in the diagnosis of melanoma and non-melanoma skin cancers in daily clinical practice...
February 3, 2024: Journal of Clinical Medicine
#39
JOURNAL ARTICLE
P Abratenko, O Alterkait, D Andrade Aldana, L Arellano, J Asaadi, A Ashkenazi, S Balasubramanian, B Baller, G Barr, D Barrow, J Barrow, V Basque, O Benevides Rodrigues, S Berkman, A Bhanderi, A Bhat, M Bhattacharya, M Bishai, A Blake, B Bogart, T Bolton, J Y Book, M B Brunetti, L Camilleri, Y Cao, D Caratelli, F Cavanna, G Cerati, A Chappell, Y Chen, J M Conrad, M Convery, L Cooper-Troendle, J I Crespo-Anadón, R Cross, M Del Tutto, S R Dennis, P Detje, A Devitt, R Diurba, Z Djurcic, R Dorrill, K Duffy, S Dytman, B Eberly, P Englezos, A Ereditato, J J Evans, R Fine, O G Finnerud, W Foreman, B T Fleming, D Franco, A P Furmanski, F Gao, D Garcia-Gamez, S Gardiner, G Ge, S Gollapinni, E Gramellini, P Green, H Greenlee, L Gu, W Gu, R Guenette, P Guzowski, L Hagaman, O Hen, C Hilgenberg, G A Horton-Smith, Z Imani, B Irwin, M Ismail, C James, X Ji, J H Jo, R A Johnson, Y-J Jwa, D Kalra, N Kamp, G Karagiorgi, W Ketchum, M Kirby, T Kobilarcik, I Kreslo, M B Leibovitch, I Lepetic, J-Y Li, K Li, Y Li, K Lin, B R Littlejohn, H Liu, W C Louis, X Luo, C Mariani, D Marsden, J Marshall, N Martinez, D A Martinez Caicedo, S Martynenko, A Mastbaum, I Mawby, N McConkey, V Meddage, J Micallef, K Miller, A Mogan, T Mohayai, M Mooney, A F Moor, C D Moore, L Mora Lepin, M M Moudgalya, S Mulleriababu, D Naples, A Navrer-Agasson, N Nayak, M Nebot-Guinot, J Nowak, N Oza, O Palamara, N Pallat, V Paolone, A Papadopoulou, V Papavassiliou, H B Parkinson, S F Pate, N Patel, Z Pavlovic, E Piasetzky, I Pophale, X Qian, J L Raaf, V Radeka, A Rafique, M Reggiani-Guzzo, L Ren, L Rochester, J Rodriguez Rondon, M Rosenberg, M Ross-Lonergan, C Rudolf von Rohr, I Safa, G Scanavini, D W Schmitz, A Schukraft, W Seligman, M H Shaevitz, R Sharankova, J Shi, E L Snider, M Soderberg, S Söldner-Rembold, J Spitz, M Stancari, J St John, T Strauss, A M Szelc, W Tang, N Taniuchi, K Terao, C Thorpe, D Torbunov, D Totani, M Toups, Y-T Tsai, J Tyler, M A Uchida, T Usher, B Viren, M Weber, H Wei, A J White, S Wolbers, T Wongjirad, M Wospakrik, K Wresilo, W Wu, E Yandel, T Yang, L E Yates, H W Yu, G P Zeller, J Zennamo, C Zhang
We present the first search for heavy neutral leptons (HNLs) decaying into νe^{+}e^{-} or νπ^{0} final states in a liquid-argon time projection chamber using data collected with the MicroBooNE detector. The data were recorded synchronously with the NuMI neutrino beam from Fermilab's main injector corresponding to a total exposure of 7.01×10^{20} protons on target. We set upper limits at the 90% confidence level on the mixing parameter |U_{μ4}|^{2} in the mass ranges 10≤m_{HNL}≤150 MeV for the νe^{+}e^{-} channel and 150≤m_{HNL}≤245 MeV for the νπ^{0} channel, assuming |U_{e4}|^{2}=|U_{τ4}|^{2}=0...
January 26, 2024: Physical Review Letters
#40
JOURNAL ARTICLE
Silvia Schobesberger, Helena Thumfart, Florian Selinger, Sarah Spitz, Carla Gonzalez, Lei Pei, Marko Poglitsch, Peter Ertl
The presence of neutralizing antibodies against SARS-CoV-2 in blood, acquired through previous infection or vaccination, is known to prevent the (re)occurrence of outbreaks unless the virus mutates. Therefore, the measurement of neutralizing antibodies constitutes an indispensable tool in assessing an individual's and a population's immunity against SARS-CoV-2. For this reason, we have developed an innovative lateral flow assay (LFA) capable of detecting blood-derived neutralizing antibodies using a biomimetic SARS-CoV-2 mock virus system...
February 9, 2024: Analytical Chemistry
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