keyword
MENU ▼
Read by QxMD icon Read
search

Spitz

keyword
https://www.readbyqxmd.com/read/28053996/zika-virus-causing-encephalomyelitis-associated-with-immunoactivation
#1
Rafael Mello Galliez, Mariana Spitz, Patricia Piazza Rafful, Marcelo Cagy, Claudia Escosteguy, Caroline Spósito Brito Germano, Elisa Sasse, Alessandro Luis Gonçalves, Paola Paz Silveira, Paula Pezzuto, Alice Maria de Magalhães Ornelas, Amilcar Tanuri, Renato Santana Aguiar, Fernanda Tovar Moll
Brazil has experienced a Zika virus (ZIKV) outbreak with increased incidence of congenital malformations and neurological manifestations. We describe a case of a 26-year-old Brazilian Caucasian man infected with ZIKV and diagnosed with encephalomyelitis. Brain and spinal cord images showed hyperintense lesions on T2 and fluid-attenuated inversion recovery (FLAIR), and levels of proinflammatory cytokines in the cerebrospinal fluid showed a remarkable increase of interleukin (IL)-6 and IL-8. The observed pattern suggests immune activation during the acute phase, along with the neurological impairment, with normalization in the recovery phase...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28041810/the-year-in-cardiothoracic-and-vascular-anesthesia-selected-highlights-from-2016
#2
REVIEW
Harish Ramakrishna, Jacob T Gutsche, Prakash A Patel, Adam S Evans, Menachem Weiner, Steven T Morozowich, Emily K Gordon, Hynek Riha, Joseph Bracker, Kamrouz Ghadimi, Sunberri Murphy, Warren Spitz, Emily MacKay, Theodore J Cios, Anita K Malhotra, Elvera Baron, Shahzad Shaefi, Jens Fassl, Stuart J Weiss, George Silvay, John G T Augoustides
No abstract text is available yet for this article.
October 14, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28027177/the-visor-flap-a-novel-design-for-scalp-wound-closure
#3
Lisa Hwang, Ni-Ka Ford, Jamie Spitz, Marco Ellis
Full-thickness scalp defects pose a reconstructive problem in the setting of infection, radiation, and underlying calvarial defects. Current options include dermal matrices, skin grafts, and local fasciocutaneous flaps. Free tissue transfer is frequently required when scalp-based flaps fail or the wound is significantly large or complex. The authors present 7 patients of complex scalp defect reconstruction using the novel visor flap. The visor flap is a bipedicled advancement flap with a triangular posterior extension...
December 23, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28024363/hierarchical-metal-oxide-topographies-replicated-from-highly-textured-graphene-oxide-by-intercalation-templating
#4
Po-Yen Chen, Muchun Liu, Thomas M Valentin, Zhongying Wang, Ruben Spitz Steinberg, Jaskiranjeet Sodhi, Ian Y Wong, Robert H Hurt
Confined assembly in the intersheet gallery spaces of two-dimensional (2D) materials is an emerging templating route for creation of ultrathin material architectures. Here, we demonstrate a general synthetic route for transcribing complex wrinkled and crumpled topographies in graphene oxide (GO) films into textured metal oxides. Intercalation of hydrated metal ions into textured GO multilayer films followed by dehydration, thermal decomposition, and air oxidation produces Zn, Al, Mn, and Cu oxide films with high-fidelity replication of the original GO textures, including "multi-generational", multiscale textures that have been recently achieved through extreme graphene compression...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27993945/human-polyomavirus-dna-detection-in-keratoacanthoma-and-spitz-naevus-no-evidence-for-a-causal-role
#5
Linnea Haeggblom, Joar Franzén, Anders Näsman
Keratoacanthomas (KA) and Spitz naevus (SN) are both lesions with unknown aetiology; therefore, the possibility of a viral involvement, more specifically the involvement of human polyomaviruses (HPyV), was investigated. In total, 22 cases of KA and 25 cases of SN were tested for the presence of HPyVs. DNA was extracted and amplified by multiplex PCR and thereafter tested with a multiplex bead-based assay for HPyVs (BKPyV, JCPyV, KIPyV, WUPyV, MCPyV, TSPyV, HPyV6, 7 and 9) and two primate viruses (SV40 and LPyV)...
December 19, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27983756/first-person-margaret-spitz-md-mph
#6
Carrie Printz
No abstract text is available yet for this article.
January 1, 2017: Cancer
https://www.readbyqxmd.com/read/27981260/once-daily-high-dose-radiation-%C3%A2-60-gy-treatment-in-limited-stage-small-cell-lung-cancer
#7
Amir Zahra, Tangel Chang, Taher Abu Hejleh, Muhammad Furqan, Gerald H Clamon, Sudershan K Bhatia, John M Watkins, Sarah L Mott, Logan L Ahmann, Kellie L Bodeker, Douglas R Spitz, John M Buatti, Bryan G Allen
BACKGROUND: To investigate outcomes and prognostic factors in patients treated with once daily high-dose (≥60 Gy) radiation therapy (HDRT) and concurrent platinum-based chemotherapy in limited stage small cell lung cancer (LS-SCLC). While we await current phase III trials to determine optimal radiation dose fractionation schemes in LS-SCLC, we report our experience in LS-SCLC with once daily HDRT. We hypothesized that HDRT would achieve similar efficacy and tolerability as twice daily therapy...
November 2016: J Oncol Transl Res
https://www.readbyqxmd.com/read/27974623/genetic-regulation-and-function-of-epidermal-growth-factor-receptor-signalling-in-patterning-of-the-embryonic-drosophila-brain
#8
David Jussen, Janina von Hilchen, Rolf Urbach
The specification of distinct neural cell types in central nervous system development crucially depends on positional cues conferred to neural stem cells in the neuroectoderm. Here, we investigate the regulation and function of the epidermal growth factor receptor (EGFR) signalling pathway in early development of the Drosophila brain. We find that localized EGFR signalling in the brain neuroectoderm relies on a neuromere-specific deployment of activating (Spitz, Vein) and inhibiting (Argos) ligands. Activated EGFR controls the spatially restricted expression of all dorsoventral (DV) patterning genes in a gene- and neuromere-specific manner...
December 2016: Open Biology
https://www.readbyqxmd.com/read/27932545/population-genomics-of-daphnia-pulex
#9
Michael Lynch, Ryan Gutenkunst, Matthew Ackerman, Ken Spitze, Zhiqiang Ye, Takahiro Maruki, Zhiyuan Jia
Using data from 83 isolates from a single population, the population genomics of the microcrustacean Daphnia pulex are described and compared to current knowledge for the only other well-studied invertebrate, Drosophila melanogaster These two species are quite similar with respect to effective population sizes and mutation rates, although some features of recombination appear to be different, with linkage disequilibrium being elevated at short (< 100 bp) distances in D. melanogaster and at long distances in D...
December 7, 2016: Genetics
https://www.readbyqxmd.com/read/27922770/on-the-nature-of-atypical-spitz-tumors
#10
Carmelo Urso
No abstract text is available yet for this article.
December 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27902770/mitochondrial-targeted-decyl-triphenylphosphonium-enhances-2-deoxy-d-glucose-mediated-oxidative-stress-and-clonogenic-killing-of-multiple-myeloma-cells
#11
Jeanine Schibler, Ann M Tomanek-Chalkley, Jessica L Reedy, Fenghuang Zhan, Douglas R Spitz, Michael K Schultz, Apollina Goel
Therapeutic advances have markedly prolonged overall survival in multiple myeloma (MM) but the disease currently remains incurable. In a panel of MM cell lines (MM.1S, OPM-2, H929, and U266), using CD138 immunophenotyping, side population staining, and stem cell-related gene expression, we demonstrate the presence of stem-like tumor cells. Hypoxic culture conditions further increased CD138low stem-like cells with upregulated expression of OCT4 and NANOG. Compared to MM cells, these stem-like cells maintained lower steady-state pro-oxidant levels with increased uptake of the fluorescent deoxyglucose analog...
2016: PloS One
https://www.readbyqxmd.com/read/27887925/a-large-degenerated-gi-stromal-tumor-presenting%C3%A2-as-a-peripancreatic-cyst
#12
James W Walter, William Klump, Francis Spitz, Adam Elfant, Henry C Ho
No abstract text is available yet for this article.
November 22, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27874879/bullous-pemphigoid-associated-with-a-lymphoepithelial-cyst-of-the-pancreas
#13
Preston W Chadwick, Francis R Spitz, Daniel M Kwa, Waine C Johnson, Warren R Heymann
Bullous pemphigoid (BP) is an acquired, autoimmune, subepidermal blistering disorder. A possible paraneoplastic association has been suggested; however, debate remains regarding the precise relationship of these neoplasms with BP. We present a case of recalcitrant BP in a 67-year-old man with a pancreatic neoplasm that was found to be a lymphoepithelial cyst. Immunoperoxidase staining of the cyst demonstrated C3d along the basement membrane of the stratified squamous epithelium, suggesting that the BP may have involved the lymphoepithelial cyst itself...
October 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27874206/spitz-nevi-and-other-spitzoid-neoplasms-in-children-overview-of-incidence-data-and-diagnostic-criteria
#14
REVIEW
Emi Dika, Giulia Maria Ravaioli, Pier Alessandro Fanti, Iria Neri, Annalisa Patrizi
Spitz nevi are benign melanocytic neoplasms characterized by epithelioid or spindle melanocytes or both. In some rare cases their presentation overlaps with the clinical and histopathologic features of malignant melanoma, so a differential diagnosis can be difficult to make. Intermediate forms between Spitz nevi and malignant melanoma, with unpredictable behavior, have been called atypical Spitz tumors. A literature search was performed to review the clinical, dermoscopic, genetic, and histopathologic aspects of spitzoid tumors...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27867070/the-shh-topological-domain-facilitates-the-action-of-remote-enhancers-by-reducing-the-effects-of-genomic-distances
#15
Orsolya Symmons, Leslie Pan, Silvia Remeseiro, Tugce Aktas, Felix Klein, Wolfgang Huber, François Spitz
Gene expression often requires interaction between promoters and distant enhancers, which occur within the context of highly organized topologically associating domains (TADs). Using a series of engineered chromosomal rearrangements at the Shh locus, we carried out an extensive fine-scale characterization of the factors that govern the long-range regulatory interactions controlling Shh expression. We show that Shh enhancers act pervasively, yet not uniformly, throughout the TAD. Importantly, changing intra-TAD distances had no impact on Shh expression...
December 5, 2016: Developmental Cell
https://www.readbyqxmd.com/read/27860221/spitz-nevi-diverse-clinical-dermatoscopic-and-histopathological-features-in-childhood
#16
Emi Dika, Iria Neri, Pier Alessandro Fanti, Alessia Barisani, Giulia Maria Ravaioli, Annalisa Patrizi
BACKGROUND AND OBJECTIVES: The characterization of clinical features and biological potential of Spitz nevi has attracted a lot of interest in past decades. The aim of our paper was to describe the clinical, dermatoscopic features as well as the clinical outcome of surgically excised Spitz nevi in three different pediatric age groups. PATIENTS AND METHODS: A retrospective study analyzing clinical features, videodermatoscopic images, histopathological diagnosis and patient outcome...
November 10, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27855509/2016-white-paper-on-recent-issues-in-bioanalysis-focus-on-biomarker-assay-validation-bav-part-2-hybrid-lba-lcms-and-input-from-regulatory-agencies
#17
An Song, Anita Lee, Fabio Garofolo, Surinder Kaur, Jeff Duggan, Christopher Evans, Joe Palandra, Lorella Di Donato, Keyang Xu, Ronald Bauer, Mark Bustard, Linzhi Chen, Laurent Cocea, Stephanie Croft, Fabrizio Galliccia, Sam Haidar, Nicola Hughes, Akiko Ishii-Watabe, Rafiqul Islam, Barry Jones, John Kadavil, Carsten Krantz, Gustavo Mendes Lima Santos, Timothy Olah, João Pedras-Vasconcelos, Ludovicus Staelens, Yoshiro Saito, Natasha Savoie, Kara Scheibner, Susan Spitz, Nilufer Tampal, Eric Thomas, Stephen Vinter, Jason Wakelin-Smith, Jan Welink, Jianing Zeng, Shaolian Zhou
The 2016 10th Workshop on Recent Issues in Bioanalysis (10(th) WRIB) took place in Orlando, Florida with participation of close to 700 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations, and regulatory agencies worldwide. WRIB was once again a 5-day, weeklong event - A Full Immersion Week of Bioanalysis including Biomarkers and Immunogenicity. As usual, it is specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small and large molecules involving LCMS, hybrid LBA/LCMS, and LBA approaches, with the focus on biomarkers and immunogenicity...
December 2016: Bioanalysis
https://www.readbyqxmd.com/read/27827934/practical-and-metal-free-synthesis-of-novel-enantiopure-amides-containing-the-potentially-bioactive-5-nitroimidazole-moiety
#18
Cédric Spitz, Fanny Mathias, Alain Gamal Giuglio-Tonolo, Thierry Terme, Patrice Vanelle
We report here a practical and metal-free synthesis of novel enantiopure amides containing the drug-like 5-nitroimidazole scaffold. The first step was a metal-free diastereoselective addition of 4-(4-(chloromethyl)phenyl)-1,2-dimethyl-5-nitro-1H-imidazole to enantiomerically pure N-tert-butanesulfinimine. Then, the N-tert-butanesulfinyl-protected amine was easily deprotected under acidic conditions. Finally, the primary amine was coupled with different acid chlorides or acids to give the corresponding amides...
November 4, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27814313/correlations-between-postural-control-and-psychological-factors-in-vestibular-schwannoma-patients
#19
Laurence Ribeyre, Elisabeth Spitz, Julien Frère, Gerome Gauchard, Cécile Parietti-Winkler
BACKGROUND: Various individual factors have been described to influence postural performances related to vestibular schwannoma. However, psychological factors may also be involved in postural variations. OBJECTIVE: To identify relationships between postural performances, illness perceptions, coping, anxiety-depression and quality of life of patients with vestibular schwannoma. METHODS: Twenty-six patients who were scheduled for a surgical removal of a vestibular schwannoma underwent posturography tests and were asked to complete psychological questionnaires three days prior to surgery...
November 3, 2016: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/27804198/debugging-eukaryotic-genetic-code-expansion-for-site-specific-click-paint-super-resolution-microscopy
#20
Ivana Nikić, Gemma Estrada Girona, Jun Hee Kang, Giulia Paci, Sofya Mikhaleva, Christine Koehler, Nataliia V Shymanska, Camilla Ventura Santos, Daniel Spitz, Edward A Lemke
Super-resolution microscopy (SRM) greatly benefits from the ability to install small photostable fluorescent labels into proteins. Genetic code expansion (GCE) technology addresses this demand, allowing the introduction of small labeling sites, in the form of uniquely reactive noncanonical amino acids (ncAAs), at any residue in a target protein. However, low incorporation efficiency of ncAAs and high background fluorescence limit its current SRM applications. Redirecting the subcellular localization of the pyrrolysine-based GCE system for click chemistry, combined with DNA-PAINT microscopy, enables the visualization of even low-abundance proteins inside mammalian cells...
December 23, 2016: Angewandte Chemie
keyword
keyword
15709
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"