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Andrew L J Dunn, Jerad M Gardner, Jennifer R Kaley, William Bellamy, Sara C Shalin
Recent studies have identified kinase fusions in Spitzoid melanocytic neoplasms, and approximately 10% of Spitzoid neoplasms harbor anaplastic lymphoma kinase (ALK) rearrangements and corresponding ALK immunoreactivity. Deep penetrating nevi (DPN), a subset of melanocytic neoplasms, have histologic and immunohistochemical overlap that have historically supported classification of DPN with blue/cellular blue nevi (CBN). However, HRAS mutations have rarely been detected in DPN, thereby also linking them to Spitz nevi...
July 2018: American Journal of Dermatopathology
Deborah Saraggi, Roberto Salmaso, Carolina Zamuner, Giada Munari, Cristiano Lanza, Mauro Salvatore Alaibac, Franco Bassetto, Massimo Rugge, Maria Cristina Montesco, Lorenzo Cerroni, Matteo Fassan
BACKGROUND: ALK gene rearrangements have been described in spitzoid lesions with plexiform growth pattern. OBJECTIVE: To investigate the prevalence of ALK alterations in a large series of spitzoid lesions. METHODS: ALK immunohistochemical and FISH analyses on 78 spitzoid plexiform lesions: 41 Spitz nevi (SN), 29 atypical Spitz tumors (ASTs), and 8 spitzoid melanomas (SMs). RESULTS: ALK immunohistochemical staining was observed in 14...
June 16, 2018: Journal of the American Academy of Dermatology
G Brancaccio, B Brunetti, E Fulgione, E Moscarella, R Alfano, G Argenziano
Spitz nevi (SN) are benign melanocytic lesions typical of childhood/adolescence that can mimic melanoma on a clinical, dermoscopic, and histopathologic level. Moreover, SN are often characterized by rapid growth and worrisome changes. Thus, their diagnosis and management may be challenging. The knowledge on prognosis and natural history of SN improved substantially in the last few years thanks to dermoscopy and a better understanding of clinic-pathologic correlations. This article is protected by copyright...
June 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Marketa Kaucka, Julian Petersen, Marketa Tesarova, Bara Szarowska, Maria Eleni Kastriti, Meng Xie, Anna Kicheva, Karl Annusver, Maria Kasper, Orsolya Symmons, Leslie Pan, Francois Spitz, Jozef Kaiser, Maria Hovorakova, Tomas Zikmund, Kazunori Sunadome, Michael P Matise, Hui Wang, Ulrika Marklund, Hind Abdo, Patrik Ernfors, Pascal Maire, Maud Wurmser, Andrei S Chagin, Kaj Fried, Igor Adameyko
Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal capsule, whereas the formation of a capsule roof is controlled by signals from the olfactory epithelium...
June 13, 2018: ELife
Kristin E Brandt, Kelly C Falls, Joshua D Schoenfeld, Samuel N Rodman, Zhimin Gu, Fenghuang Zhan, Joseph J Cullen, Brett A Wagner, Garry R Buettner, Bryan G Allen, Daniel J Berg, Douglas R Spitz, Melissa A Fath
No abstract text is available yet for this article.
June 8, 2018: Redox Biology
Seijirow Goya, Nobuyuki Kanno, Kenji Teshima, Takanori Anndo, Takahiro Fujioka
A 4-year-old, 5.9-kg female Japanese Spitz presented with syncope and exercise intolerance. Echocardiography revealed an ostium primum atrial septal defect (ASD), a cleft mitral valve, mitral valve regurgitation (MR), and tricuspid regurgitation (TR) (velocity: 3.6 m/sec, pressure gradient: 52 mmHg), leading to a diagnosis of partial atrioventricular septal defect (AVSD) with moderate pulmonary hypertension (PH). Open-heart surgery using cardiopulmonary bypass was performed through right atriotomy. The cleft of the mitral valve was sutured with polypropylene and the AVSD was closed using an autologous pericardial patch fixed with glutaraldehyde...
June 6, 2018: Journal of Veterinary Medical Science
Hormuzd A Katki, Stephanie A Kovalchik, Lucia C Petito, Li C Cheung, Eric Jacobs, Ahmedin Jemal, Christine D Berg, Anil K Chaturvedi
Background: Lung cancer screening guidelines recommend using individualized risk models to refer ever-smokers for screening. However, different models select different screening populations. The performance of each model in selecting ever-smokers for screening is unknown. Objective: To compare the U.S. screening populations selected by 9 lung cancer risk models (the Bach model; the Spitz model; the Liverpool Lung Project [LLP] model; the LLP Incidence Risk Model [LLPi]; the Hoggart model; the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Model 2012 [PLCOM2012]; the Pittsburgh Predictor; the Lung Cancer Risk Assessment Tool [LCRAT]; and the Lung Cancer Death Risk Assessment Tool [LCDRAT]) and to examine their predictive performance in 2 cohorts...
May 15, 2018: Annals of Internal Medicine
Timothy VandenBoom, Victor L Quan, Bin Zhang, Erin M Garfield, Betty Y Kong, Maria C Isales, Elnaz Panah, Catherine Igartua, Timothy Taxter, Nike Beaubier, Kevin White, Pedram Gerami
Recent molecular studies of spitzoid neoplasms have identified mutually exclusive kinase fusions involving ROS1, ALK, RET, BRAF, NTRK1, MET, and NTRK3 as early initiating genomic events. Pigmented spindle cell nevus (PSCN) of Reed is a morphologic variant of Spitz and may be very diagnostically challenging, having histologic features concerning for melanoma. Their occurrence in younger patients, lack of association to sun exposure, and rapid early growth phase similar to Spitz nevi suggest fusions may also play a significant role in these lesions...
May 22, 2018: American Journal of Surgical Pathology
Kerstin Kanonenberg, Olivia Spitz, Isabelle N Erenburg, Tobias Beer, Lutz Schmitt
Type I secretion systems are widespread in Gram-negative bacteria and mediate the one-step translocation of a large variety of proteins serving for diverse purposes, including nutrient acquisition or bacterial virulence. Common to most substrates of type I secretion systems is the presence of a C-terminal secretion sequence that is not cleaved during or after translocation. Furthermore, these protein secretion nanomachineries are always composed of an ABC transporter, a membrane fusion protein, both located in the inner bacterial membrane, and a protein of the outer membrane...
June 1, 2018: FEMS Microbiology Letters
Giovanni Biondo, Matteo Gnone, Simona Sola, Carlotta Pastorino, Cesare Massone
Spark's nevus is a particular type of melanocytic nevus that on histology shows features of both Spitz's and Clark's nevus. Clinically, it is an asymmetric, irregular, multicolored, pigmented lesion that is not clearly distinguishable from melanoma or dysplastic (Clark's) nevus. Dermoscopic features have not been described yet, and one could speculate that they are similar to those of Clark's nevi because the histopathologic architecture of Spark's nevus is similar to that of a Clark's nevus, resembling Spitz's nevi in the epithelioid morphology of melanocytes...
April 2018: Dermatology Practical & Conceptual
S M Amin, A M Haugh, J A Bubley, A E Verzì, E A Merkel, C Y Lee, V L Quan, E M Garfield, L M Sholl, B Zhang, P Gerami
BACKGROUND: Clonal naevi are characterized by a focal proliferation of pigmented melanocytes in an otherwise banal naevus. These subclones are often composed of aggregates of larger, epithelioid melanocytes with nuclear atypia and dusty-grey cytoplasmic pigmentation, which are referred to as 'pulverocytes', and this finding may lead to a misdiagnosis of malignant melanoma (MM). AIM: To characterize the significance of subclones of dusty-grey pigmented epithelioid melanocytes within spitzoid neoplasms...
May 20, 2018: Clinical and Experimental Dermatology
Sambit K Mohanty, Shivani Sharma, Dinesh Pradhan, Shivani R Kandukuri, Navid Farahani, Catherine Barry, Julie M Wu, David Frishberg, Bonnie Balzer
Microphthalmia-associated transcription factor (MiTF) is used as a marker of melanocytic differentiation. However, MiTF immunoexpression has also been observed in histiocytes, macrophages, smooth muscle cells and fibroblasts, which raise the concern of fibrohistiocytic (FH) lesions being misdiagnosed as melanoma based on MiTF immunoreactivity. MiTF has been known to be positive in FH tumors, but this is the first study evaluating ninety-three fibrohistiocytic neoplasms to understand and delineate the staining pattern of MiTF in these tumors...
May 11, 2018: Pathology, Research and Practice
Elena Castelli, Elisabetta Orlando, Giuseppe Pistone, Maria R Bongiorno
Spitz nevi, atypical Spitz tumors and Spitzoid melanoma, the three clinicopathologic forms that constitute the spectrum of the Spitz-type melanocytic lesions, share a histologic picture characterized by large spindle and/or epithelioid ganglion-like cells, with various admixtures of multinucleate bizarre cells. This remarkable cytology has always been interpreted as an unusual, as well as unexplained form of atypia. We report a case of atypical Spitz tumor with Homer Wright-like rosettes, a feature characteristic of ganglioneuroblastic proliferation...
May 16, 2018: American Journal of Dermatopathology
Carsten Bahr, Lisa von Paleske, Veli V Uslu, Silvia Remeseiro, Naoya Takayama, Stanley W Ng, Alex Murison, Katja Langenfeld, Massimo Petretich, Roberta Scognamiglio, Petra Zeisberger, Amelie S Benk, Ido Amit, Peter W Zandstra, Mathieu Lupien, John E Dick, Andreas Trumpp, François Spitz
In the originally published version of this Letter, ref. 43 was erroneously provided twice. In the 'Estimation of relative cell-type-specific composition of AML samples' section in the Methods, the citation to ref. 43 after the GEO dataset GSE24759 is correct. However, in the 'Mice' section of the Methods, the citation to ref. 43 after 'TAMERE' should have been associated with a new reference1. The original Letter has been corrected online (with the new reference included as ref. 49).
May 16, 2018: Nature
Burkhard Jansen, Doyle Hansen, Ronald Moy, Maesa Hanhan, Zuxu Yao
INTRODUCTION: Pediatric Spitz nevi can pose significant diagnostic challenges to both clinicians and dermatopathologists when the current image-recognition based gold standard is employed. PRAME (preferentially expressed antigen in melanoma) and/or LINC (long intergeneic non-coding RNA 518) gene expression in adult patients in samples obtained non-invasively via adhesive patches differentiates primary melanomas from atypical nevi and other pigmented lesions with a NPV of over 99%, a sensitivity of 91%, and a specificity of 69%, to help clinicians rule out melanoma and the need for surgical biopsies of atypial pigmented lesions with suspicion for melanoma...
May 1, 2018: Journal of Drugs in Dermatology: JDD
Dahlia Tharwat, Marion Trousselard, Mélanie Balès, Anne-Laure Sutter-Dallay, Dominique Fromage, Elisabeth Spitz, Dominique Dallay, Thierry Harvey, Eric Welter, Frédéric Coatleven, Lydie Cherier, Frédérique Teissèdre, Jean-Luc Pouly, Frédéric Dutheil, Anaïs M Duffaud
INTRODUCTION: The prevalence of postnatal depression (PND) is significant: reaching up to 20% in the general population. In mechanistic terms, the risk of PND lies in an interaction between a maternal psychophysiological vulnerability and a chronic environmental context of stress. On the one hand, repetition of stressor during pregnancy mimics a chronic stress model that is relevant to the study of the allostatic load and the adaptive mechanisms. On the other hand, vulnerability factors reflect a psychological profile mirroring mindfulness functioning (psychological quality that involves bringing one's complete and non-judgemental attention to the present experience on a moment-to-moment basis)...
May 3, 2018: BMJ Open
Gerardo Ferrara, Antonietta Partenzi, Alessandra Filosa
Several controversies are still ongoing about sentinel node biopsy in melanoma. It is basically a staging procedure for melanoma > 0.75 mm in thickness or for thinner melanoma in the presence of ulceration, high mitotic rate, and/or lymphovascular invasion. Complete lymph node dissection after a positive sentinel node can also allow a better locoregional disease control but seems not to prevent the development of distant metastases. The use of sentinel node biopsy in atypical Spitz tumors should be discouraged because of their peculiar biological properties...
January 2018: Dermatopathology (Basel, Switzerland)
Swetlana Schuster, Aditi Lahiri
On the evidence of four lexical-decision tasks in German, we examine speakers' sensitivity to internal morphological composition and abstract morphological rules during the processing of derived words, real and novel. In a lexical-decision task with delayed priming, speakers were presented with two-step derived nouns such as Heilung "healing" derived from the adjective heil "intact" via the verb heilen "to heal." These were compared with two sets of derived novel words, one with and the other without an intermediate verb; for example, *Spitzung "sharpening" from spitz "sharp" via spitzen "sharpen" (Experiment 1) and *Hübschung "beautifying" from hübsch "pretty" via *hübschen "beautify" (Experiment 2)...
April 26, 2018: Journal of Experimental Psychology. Learning, Memory, and Cognition
Karine Legrand, Edith Lecomte, Johanne Langlois, Laurent Muller, Laura Saez, Marie-Hélène Quinet, Philip Böhme, Elisabeth Spitz, Abdou Y Omorou, Serge Briançon
Background: Despite social inequalities in overweight/obesity prevalence, evidence-based public health interventions to reduce them are scarce. The PRALIMAP-INÈS trial aimed to investigate whether a strengthened-care management for adolescents with low socioeconomic status has an equivalent effect in preventing and reducing overweight as a standard-care management for high socioeconomic status adolescents. Methods: PRALIMAP-INÈS was a mixed, prospective and multicenter trial including 35 state-run schools...
September 2017: Contemporary Clinical Trials Communications
A A Aguilar-Arevalo, B C Brown, L Bugel, G Cheng, E D Church, J M Conrad, R L Cooper, R Dharmapalan, Z Djurcic, D A Finley, R S Fitzpatrick, R Ford, F G Garcia, G T Garvey, J Grange, W Huelsnitz, C Ignarra, R Imlay, R A Johnson, J R Jordan, G Karagiorgi, T Katori, T Kobilarcik, W C Louis, K Mahn, C Mariani, W Marsh, G B Mills, J Mirabal, C D Moore, J Mousseau, P Nienaber, B Osmanov, Z Pavlovic, D Perevalov, H Ray, B P Roe, A D Russell, M H Shaevitz, J Spitz, I Stancu, R Tayloe, R T Thornton, R G Van de Water, M O Wascko, D H White, D A Wickremasinghe, G P Zeller, E D Zimmerman
We report the first measurement of monoenergetic muon neutrino charged current interactions. MiniBooNE has isolated 236 MeV muon neutrino events originating from charged kaon decay at rest (K^{+}→μ^{+}ν_{μ}) at the NuMI beamline absorber. These signal ν_{μ}-carbon events are distinguished from primarily pion decay in flight ν_{μ} and ν[over ¯]_{μ} backgrounds produced at the target station and decay pipe using their arrival time and reconstructed muon energy. The significance of the signal observation is at the 3...
April 6, 2018: Physical Review Letters
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