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Margin fit

Andrea Callegaro, Bart Spiessens, Benjamin Dizier, Fernando U Montoya, Hans C van Houwelingen
In this paper, we considered different methods to test the interaction between treatment and a potentially large number (p) of covariates in randomized clinical trials. The simplest approach was to fit univariate (marginal) models and to combine the univariate statistics or p-values (e.g., minimum p-value). Another possibility was to reduce the dimension of the covariates using the principal components (PCs) and to test the interaction between treatment and PCs. Finally, we considered the Goeman global test applied to the high-dimensional interaction matrix, adjusted for the main (treatment and covariates) effects...
October 20, 2016: Biometrical Journal. Biometrische Zeitschrift
Rafael Sauter, Ruizhu Huang, Bruno Ledergerber, Manuel Battegay, Enos Bernasconi, Matthias Cavassini, Hansjakob Furrer, Matthias Hoffmann, Mathieu Rougemont, Huldrych F Günthard, Leonhard Held
Plasma HIV viral load is related to declining CD4 lymphocytes. The extent to which CD8 cells, in addition to RNA viral load, predict the depletion of CD4 cells is not well characterized so far. We examine if CD8 cell count is a prognostic factor for CD4 cell counts during an HIV infection.A longitudinal analysis is conducted using data from the Swiss HIV cohort study collected between January 2000 and October 2014. Linear mixed regression models were applied to observations from HIV-1-infected treatment naive patients (NAIVE) and cART-treated patients to predict the short-term evolution of CD4 cell counts...
October 2016: Medicine (Baltimore)
P Pott, A Rzasa, M Stiesch, M Eisenburger
This in vitro study compares a new system for manual chair side fabrication of indirect composite restorations, which uses silicone models after alginate impressions, to CAD/CAM-technology and laboratory manual production techniques. MATRIALS AND METHODS: and study design Each 10 composite inlays were fabricated using different types of production techniques: CAD/CAM- technology (A), the new inlay system (B), plaster model after alginate impression (C) or silicone impression (D). The inlays were adapted into a metal tooth and silicone replicas of the cement gaps were made and measured...
September 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
John D Kraemer
BACKGROUND: Bicycle helmet laws generally increase helmet usage, but few studies assess whether helmet laws reduce disparities. The objective of this study is to assess changes in racial/ethnic disparities in helmet use among high school students in urban jurisdictions where laws were previously determined to increase overall helmet use. METHODS: Log-binomial models were fit to four districts' 1991-2013 Youth Risk Behavior Survey (YRBS) data. Post-regression predictive margins were used to calculate adjusted bicycle helmet use proportions, assess before-to-after changes in race/ethnicity specific helmet use, and estimate changes in disparities from jurisdictions' white subpopulations...
December 2016: Injury Epidemiology
Santosh Kumar, Daizy Bharti, Pablo Quintela-Alonso, Mann Kyoon Shin, Antonietta La Terza
The morphology and morphogenesis of two stylonychid ciliates, Stylonychia ammermanniGupta et al., 2001 and Tetmemena bifaria (Stokes, 1887) Berger, 2001, isolated from soil samples of Lombardia region, Northern Italy, and water samples from Cheonggancheon stream, South Korea, were investigated. The Italian population of S. ammermanni was found to be very similar in morphology to the Indian type population and the junior synonym S. harbinensisShi and Ammermann, 2004 since most of the morphometric data overlapped...
September 23, 2016: European Journal of Protistology
Fernando Cervantes-Sanchez, Ivan Cruz-Aceves, Arturo Hernandez-Aguirre, Juan Gabriel Aviña-Cervantes, Sergio Solorio-Meza, Manuel Ornelas-Rodriguez, Miguel Torres-Cisneros
This paper presents a novel method for improving the training step of the single-scale Gabor filters by using the Boltzmann univariate marginal distribution algorithm (BUMDA) in X-ray angiograms. Since the single-scale Gabor filters (SSG) are governed by three parameters, the optimal selection of the SSG parameters is highly desirable in order to maximize the detection performance of coronary arteries while reducing the computational time. To obtain the best set of parameters for the SSG, the area (Az ) under the receiver operating characteristic curve is used as fitness function...
2016: Computational Intelligence and Neuroscience
Lorena Oliveira Pedroche, Sérgio Rocha Bernardes, Moira Pedroso Leão, Cibele Cândida de Almeida Kintopp, Gisele Maria Correr, Bárbara Pick Ornaghi, Carla Castiglia Gonzaga
The objective of this study was to evaluate the marginal and internal fit of zirconia copings obtained with different digital scanning methods. A human mandibular first molar was set in a typodont with its adjacent and antagonist teeth and prepared for an all-ceramic crown. Digital impressions were made using an intraoral scanner (3Shape). Polyvinyl siloxane impressions and Type IV gypsum models were also obtained and scanned with a benchtop laboratory scanner (3Shape D700). Ten zirconia copings were fabricated for each group using CAD-CAM technology...
October 10, 2016: Brazilian Oral Research
Zoë M McLaren, Kathryn Schnippel, Alana Sharp
OBJECTIVE: Identifying those infected with tuberculosis (TB) is an important component of any strategy for reducing TB transmission and population prevalence. The Stop TB Global Partnership recently launched an initiative with a focus on key populations at greater risk for TB infection or poor clinical outcomes, due to housing and working conditions, incarceration, low household income, malnutrition, co-morbidities, exposure to tobacco and silica dust, or barriers to accessing medical care...
2016: PloS One
Andrea R Ashbaugh, Stephanie Houle-Johnson, Christophe Herbert, Wissam El-Hage, Alain Brunet
The purpose of this study is to assess the psychometric properties of a French version of the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5), a self-report measure of posttraumatic stress disorder (PTSD) symptoms, and to further validate the existing English version of the measure. Undergraduate students (n = 838 English, n = 262 French) completed the PCL-5 as well as other self-report symptom measures of PTSD and depression online. Both the English and French versions PCL-5 total scores demonstrated excellent internal consistency (English: α = ...
2016: PloS One
Mengyi Liu, Shiguang Shan, Ruiping Wang, Xilin Chen
Facial expression is a temporally dynamic event which can be decomposed into a set of muscle motions occurring in different facial regions over various time intervals. For dynamic expression recognition, two key issues, temporal alignment and semantics-aware dynamic representation, must be taken into account. In this paper, we attempt to solve both problems via manifold modeling of videos based on a novel midlevel representation, i.e. expressionlet. Specifically, our method contains three key stages: 1) each expression video clip is characterized as a spatial-temporal manifold (STM) formed by dense low-level features; 2) a Universal Manifold Model (UMM) is learned over all low-level features and represented as a set of local modes to statistically unify all the STMs...
October 5, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Won Sik Jang, Lawrence H C Kim, Cheol Yong Yoon, Koon Ho Rha, Young Deuk Choi, Sung Joon Hong, Won Sik Ham
BACKGROUND: Current National Comprehensive Cancer Network guidelines recommend postoperative radiation therapy based only on adverse pathologic findings (APFs), irrespective of preoperative risk group. We assessed whether a model incorporating both the preoperative risk group and APFs could predict long-term oncologic outcomes better than a model based on APFs alone. METHODS: We retrospectively reviewed 4,404 men who underwent radical prostatectomy (RP) at our institution between 1992 and 2014...
2016: PloS One
Serena Halls, Rebecca-Jane Law, Jeremy G Jones, David A Markland, Peter J Maddison, Jeanette M Thom
OBJECTIVES: Although exercise is an important factor in the management of rheumatoid arthritis (RA), research indicates that patients perceive that health professionals (HPs) are uncertain about the place of exercise in treatment and its relationship with joint damage. The present study investigated the perceptions of HPs regarding the effects of exercise on joint health in RA patients. METHODS: A questionnaire investigating perceptions of exercise and joint health was distributed via professional networks and websites...
October 6, 2016: Musculoskeletal Care
Renato Roperto, Hussein Assaf, Thiago Soares-Porto, Lisa Lang, Sorin Teich
BACKGROUND: Different CAD/CAM machines' generation may impact the restoration overall quality. The present study evaluated the marginal fit of CAD/CAM restorations manufactured with different generations of CEREC milling unit systems. MATERIAL AND METHODS: Sixteen typodont teeth were divided into two groups (n=8) according to the machine's generation assigned. These are control group (G1): Cerec AC with Bluecam/Cerec 3 milling unit and (G2): Cerec AC with Bluecam/MC XL Premium Package milling unit...
October 2016: Journal of Clinical and Experimental Dentistry
W Hartwig, A Gluth, U Hinz, D Koliogiannis, O Strobel, T Hackert, J Werner, M W Büchler
BACKGROUND: In the recent International Study Group of Pancreatic Surgery (ISGPS) consensus on extended pancreatectomy, several issues on perioperative outcome and long-term survival remained unclear. Robust data on outcomes are sparse. The present study aimed to assess the outcome of extended pancreatectomy for borderline resectable and locally advanced pancreatic cancer. METHODS: A consecutive series of patients with primary pancreatic adenocarcinoma undergoing extended pancreatectomies, as defined by the new ISGPS consensus, were compared with patients who had a standard pancreatectomy...
September 30, 2016: British Journal of Surgery
Tomohiro Hanazawa, Kei Asayama, Daisuke Watabe, Miki Hosaka, Michihiro Satoh, Daisaku Yasui, Taku Obara, Ryusuke Inoue, Hirohito Metoki, Masahiro Kikuya, Yutaka Imai, Takayoshi Ohkubo
Seasonal variation of blood pressure (BP) has been reported in small populations or by BP levels captured at only a few points in a year, for example, summer and winter. We aimed to investigate the multiyear seasonal variation in self-measured home BP among hypertensive patients receiving antihypertensive medications. We selected 1649 eligible patients receiving antihypertensive drug treatment, and weekly averaged home BPs were analyzed throughout the follow-up period. Systolic and diastolic home BPs were fitted with the cosine function: 'Variation+Other Effects+Intercept', in which the 'Variation' was expressed by a cosine curve with three parameters representing: (1) maximum-minimum difference of home BP in one cycle of the cosine curve; (2) time required for one cycle of the cosine curve for home BP variation; and (3) time at which home BP reached the maximum point...
September 29, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Norah K Alajaji, David Bardwell, Matthew Finkelman, Ala Ali
OBJECTIVES: To evaluate the marginal and internal adaptation of CAD/CAM lithium-disilicate inlay restorations fabricated by two milling systems (Five and Three-axis), and a traditional heat-press technique. METHODS: Fifteen premolar teeth with an MOD cavity preparation were fabricated. Lithium-disilicate inlay restorations were obtained by three fabrication techniques and fitted to their dies (n = 15/gp) as follows: Group-1, three-axis milling system, Group-2, five-axis milling system, Group-3, conventional heat-press technique...
September 29, 2016: Journal of Esthetic and Restorative Dentistry
Marco Zeltner, Irena Sailer, Sven Mühlemann, Mutlu Özcan, Christoph H F Hämmerle, Goran I Benic
STATEMENT OF PROBLEM: Trials comparing the overall performance of digital with that of conventional workflows in restorative dentistry are needed. PURPOSE: The purpose of the third part of a series of investigations was to test whether the marginal and internal fit of monolithic crowns fabricated with fully digital workflows differed from that of crowns fabricated with the conventional workflow. MATERIAL AND METHODS: In each of 10 participants, 5 monolithic lithium disilicate crowns were fabricated for the same abutment tooth according to a randomly generated sequence...
September 24, 2016: Journal of Prosthetic Dentistry
Eun-Ha Kim, Du-Hyeong Lee, Sung-Min Kwon, Tae-Yub Kwon
STATEMENT OF PROBLEM: Although new digital manufacturing techniques are attracting interest in dentistry, few studies have comprehensively investigated the marginal fit of fixed dental prostheses fabricated with such techniques. PURPOSE: The purpose of this in vitro microcomputed tomography (μCT) study was to evaluate the marginal fit of cobalt-chromium (Co-Cr) alloy copings fabricated by casting and 3 different computer-aided design and computer-aided manufacturing (CAD-CAM)-based processing techniques and alloy systems...
September 24, 2016: Journal of Prosthetic Dentistry
Alessandra C de Paula Silveira, Sacha B Chaves, Leandro A Hilgert, Ana Paula D Ribeiro
STATEMENT OF PROBLEM: The precision of fit of chairside computer-aided design and computer-aided manufacturing (CAD-CAM) complete crowns is affected by digital impression and restorative material. PURPOSE: The purpose of this in vitro study was to evaluate by microcomputed tomography (μCT) the marginal and internal adaptation of composite resin and ceramic complete crowns fabricated with 2 different intraoral cameras and 2 restorative materials. MATERIAL AND METHODS: Ten extracted human third molars received crown preparations...
September 24, 2016: Journal of Prosthetic Dentistry
Anna Gabriella Camacho Presotto, Cláudia Lopes Brilhante Bhering, Marcelo Ferraz Mesquita, Valentim Adelino Ricardo Barão
STATEMENT OF PROBLEM: Several studies have shown the superiority of computer-assisted design and computer-assisted manufacturing (CAD-CAM) technology compared with conventional casting. However, an advanced technology exists for casting procedures (the overcasting technique), which may serve as an acceptable and affordable alternative to CAD-CAM technology for fabricating 3-unit implant-supported fixed dental prostheses (FDPs). PURPOSE: The purpose of this in vitro study was to evaluate, using quantitative photoelastic analysis, the effect of the prosthetic framework fabrication method (CAD-CAM and overcasting) on the marginal fit and stress transmitted to implants...
September 22, 2016: Journal of Prosthetic Dentistry
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