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Margin fit

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https://www.readbyqxmd.com/read/27905878/genomic-prediction-using-preselected-dna-variants-from-a-gwas-with-whole-genome-sequence-data-in-holstein-friesian-cattle
#1
Roel F Veerkamp, Aniek C Bouwman, Chris Schrooten, Mario P L Calus
BACKGROUND: Whole-genome sequence data is expected to capture genetic variation more completely than common genotyping panels. Our objective was to compare the proportion of variance explained and the accuracy of genomic prediction by using imputed sequence data or preselected SNPs from a genome-wide association study (GWAS) with imputed whole-genome sequence data. METHODS: Phenotypes were available for 5503 Holstein-Friesian bulls. Genotypes were imputed up to whole-genome sequence (13,789,029 segregating DNA variants) by using run 4 of the 1000 bull genomes project...
December 1, 2016: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/27898387/a-novel-adaboost-framework-with-robust-threshold-and-structural-optimization
#2
Peng-Bo Zhang, Zhi-Xin Yang
The AdaBoost algorithm is a popular ensemble method that combines several weak learners to boost generalization performance. However, conventional AdaBoost.RT algorithms suffer from the limitation that the threshold value must be manually specified rather than chosen through a self-adaptive mechanism, which cannot guarantee a result in an optimal model for general cases. In this paper, we present a generic AdaBoost framework with robust threshold mechanism and structural optimization on regression problems...
November 24, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27889705/effect-estimation-in-point-exposure-studies-with-binary-outcomes-and-high-dimensional-covariate-data-a-comparison-of-targeted-maximum-likelihood-estimation-and-inverse-probability-of-treatment-weighting
#3
Menglan Pang, Tibor Schuster, Kristian B Filion, Mireille E Schnitzer, Maria Eberg, Robert W Platt
Inverse probability of treatment weighting (IPW) and targeted maximum likelihood estimation (TMLE) are relatively new methods proposed for estimating marginal causal effects. TMLE is doubly robust, yielding consistent estimators even under misspecification of either the treatment or the outcome model. While IPW methods are known to be sensitive to near violations of the practical positivity assumption (e. g., in the case of data sparsity), the consequences of this violation in the TMLE framework for binary outcomes have been less widely investigated...
November 29, 2016: International Journal of Biostatistics
https://www.readbyqxmd.com/read/27886136/interactions-between-the-multicolored-asian-lady-beetle-harmonia-axyridis-and-the-parasitoid-dinocampus-coccinellae
#4
Maria Luisa Dindo, Santolo Francati, Alberto Lanzoni, Cinzia di Vitantonio, Elisa Marchetti, Giovanni Burgio, Stefano Maini
Harmonia axyridis (Pallas) has been introduced either intentionally or accidentally in different areas outside its native range, where it is often regarded as invasive. Dinocampus coccinellae (Schrank) has been recorded to parasitize H. axyridis in the field, both in the native and introduced areas, Italy included. The percent of parasitism found in our field investigation was low (four percent). The effect of exposure time of H. axyridis to D. coccinellae and the impact of parasitization on host longevity, oviposition capacity and egg fertility were evaluated in the laboratory...
November 24, 2016: Insects
https://www.readbyqxmd.com/read/27882725/analysis-of-risk-factors-to-predict-communicating-hydrocephalus-following-gamma-knife-radiosurgery-for-intracranial-schwannoma
#5
Seunghoon Lee, Seong-Wook Seo, Juyoung Hwang, Ho Jun Seol, Do-Hyun Nam, Jung-Il Lee, Doo-Sik Kong
Communicating hydrocephalus (HCP) in vestibular schwannomas (VS) after gamma knife radiosurgery (GKRS) has been reported in the literature. However, little information about its incidence and risk factors after GKRS for intracranial schwannomas is yet available. The objective of this study was to identify the incidence and risk factors for developing communicating HCP after GKRS for intracranial schwannomas. We retrospectively reviewed a total of 702 patients with intracranial schwannomas who were treated with GKRS between January 2002 and December 2015...
November 23, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27876674/brief-report-a-survey-of-thymic-carcinoma-management-patterns-among-international-thymic-malignancy-interest-group-itmig-physicians-with-consensus-from-the-thymic-carcinoma-working-group
#6
Annemarie Shepherd, Gregory Riely, Frank Detterbeck, Charles B Simone, Usman Ahmad, James Huang, Robert Korst, Arun Rajan, Andreas Rimner
INTRODUCTION: Thymic carcinomas are rare epithelial malignancies with limited data to guide management. METHODS: In order to identify areas of agreement and variability in current clinical practice, a 16-question electronic survey was given to members of the International Thymic Malignancy Interest Group (ITMIG). Areas of controversy were discussed with the Thymic Carcinoma Working Group and consensus was achieved, as described. RESULTS: One hundred ITMIG members responded...
November 19, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27876630/disruptions-of-the-genes-involved-in-lysine-biosynthesis-iron-acquisition-and-secondary-metabolisms-affect-virulence-and-fitness-in-metarhizium-robertsii
#7
Bruno Giuliano Garisto Donzelli, B Gillian Turgeon, Donna M Gibson, Stuart B Krasnoff
Based on genomic analysis, polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) pathways account for biosynthesis of the majority of the secondary metabolites produced by the entomopathogenic fungus Metarhizium robertsii. To evaluate the contribution of these pathways to M. robertsii fitness and/or virulence, mutants deleted for mrpptA, the Sfp-type 4' phosphopantetheinyl transferase gene required for their activation were generated. ΔmrpptA strains were deficient in PKS and NRPS activity resulting in colonies lacking the typical green pigment that failed to produce the nonribosomal peptides destruxins, serinocylins, and the siderophores ferricrocin and metachelins, as well as the hybrid polyketide-peptides NG-39x that are all produced by the wild type (WT) M...
November 19, 2016: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/27873225/how-consistent-is-the-relationship-between-improved-glucose-control-and-modelled-health-outcomes-for-people-with-type-2-diabetes-mellitus-%C3%A2-a-systematic-review
#8
REVIEW
Xinyang Hua, Thomas Wai-Chun Lung, Andrew Palmer, Lei Si, William H Herman, Philip Clarke
BACKGROUND: There are an increasing number of studies using simulation models to conduct cost-effectiveness analyses for type 2 diabetes mellitus. OBJECTIVE: To evaluate the relationship between improvements in glycosylated haemoglobin (HbA1c) and simulated health outcomes in type 2 diabetes cost-effectiveness studies. METHODS: A systematic review was conducted on MEDLINE and EMBASE to collect cost-effectiveness studies using type 2 diabetes simulation models that reported modelled health outcomes of blood glucose-related interventions in terms of quality-adjusted life-years (QALYs) or life expectancy (LE)...
November 21, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27870778/inter-visit-test-retest-variability-of-oct-in-glaucoma
#9
John Graham Pearce, Ted Maddess
PURPOSE: To determine the inter-visit test-retest variability (TRV) of a spectral domain optical coherence tomograph, the Topcon 3D OCT-2000, in the measurement of optic nerve head topography, peripapillary retinal nerve fiber layer (pRNFL), and macular ganglion cell complex (GCC) parameters in glaucoma patients. We also examine whether TRV with this instrument varies with the extent of glaucomatous damage. METHODS: Twenty-four subjects with varying degrees of glaucoma severity provided 41 eyes with usable results for the study...
November 19, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27867423/marginalized-zero-altered-models-for-longitudinal-count-data
#10
Loni Philip Tabb, Eric J Tchetgen Tchetgen, Greg A Wellenius, Brent A Coull
Count data often exhibit more zeros than predicted by common count distributions like the Poisson or negative binomial. In recent years, there has been considerable interest in methods for analyzing zero-inflated count data in longitudinal or other correlated data settings. A common approach has been to extend zero-inflated Poisson models to include random effects that account for correlation among observations. However, these models have been shown to have a few drawbacks, including interpretability of regression coefficients and numerical instability of fitting algorithms even when the data arise from the assumed model...
October 2016: Statistics in Biosciences
https://www.readbyqxmd.com/read/27866698/comparison-of-margin-discrepancy-of-complete-gold-crowns-fabricated-using-printed-milled-and-conventional-hand-waxed-patterns
#11
Sergio Munoz, Van Ramos, Douglas P Dickinson
STATEMENT OF PROBLEM: The recent application of printing for the fabrication of dental restorations has not been compared and evaluated for margin discrepancy (margin fit) with restorations fabricated using milling and conventional hand-waxing techniques. PURPOSE: The purpose of this in vitro study was to evaluate and compare margin discrepancy of complete gold crowns (CGCs) fabricated from printed, milled, and conventional hand-waxed patterns. MATERIAL AND METHODS: Thirty crown patterns were produced by each of 3 different methods: printed by ProJet DP 3000, milled by LAVA CNC 500, and hand waxed, then invested and cast into CGCs...
November 17, 2016: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/27859169/nipped-in-the-bud-mesograzer-feeding-preference-contributes-to-kelp-decline
#12
John M O'Brien, Robert E Scheibling
Small invertebrate grazers can disproportionately reduce plant fitness by discriminately consuming valuable tissues, but the context and attendant consequences of this activity at higher levels of ecological organization rarely are considered. To assess the impact of a gastropod mesograzer Lacuna vincta on fecundity and potential reproductive output of the habitat-forming kelp Saccharina latissima, we measured the intensity and distribution of grazing damage on kelp blades at five sites of varying kelp density, during the annual reproductive peak (October-November) in Nova Scotia...
July 2016: Ecology
https://www.readbyqxmd.com/read/27836145/in%C3%A2-vitro-evaluation-of-marginal-discrepancy-of-monolithic-zirconia-restorations-fabricated-with-different-cad-cam-systems
#13
Tamer A Hamza, Rana M Sherif
STATEMENT OF PROBLEM: Dental laboratories use different computer-aided design and computer-aided manufacturing (CAD-CAM) systems to fabricate fixed prostheses; however, limited evidence is available concerning which system provides the best marginal discrepancy. PURPOSE: The purpose of this in vitro study was to evaluate the marginal fit of 5 different monolithic zirconia restorations milled with different CAD-CAM systems. MATERIAL AND METHODS: Thirty monolithic zirconia crowns were fabricated on a custom-designed stainless steel die and were divided into 5 groups according to the type of monolithic zirconia crown and the CAD-CAM system used: group TZ, milled with an MCXL milling machine; group CZ, translucent zirconia milled with a motion milling machine; group ZZ, zirconia milled with a dental milling unit; group PZ, translucent zirconia milled with a zirconia milling unit; and group BZ, solid zirconia milled using an S1 VHF milling machine...
November 8, 2016: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/27829765/comparative-study-on-the-tensile-bond-strength-and-marginal-fit-of-complete-veneer-cast-metal-crowns-using-various-luting-agents-an-in-vitro-study
#14
B Devi Parameswari, M Rajakumar, G Lambodaran, Shyam Sundar
INTRODUCTION: Several commercially available luting agents are used to cement the dental restorations such as intra-coronal, extra-coronal, and fixed partial dentures. Tensile bond strength (TBS) and accurate marginal fit are the essential factors to determine the good clinical results in fixed prosthesis. The retentivity of the luting cements is assessed by their adhesive capacity over the tooth surface and metal surface. Generally, the adhesive ability has been evaluated with in vitro testing, with tensile bond tests...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27825689/safety-and-effectiveness-of-cadaveric-allograft-sternochondral-replacement-after-sternectomy-a-new-tool-for-the-reconstruction-of-anterior-chest-wall
#15
Giuseppe Marulli, Andrea Dell'amore, Francesca Calabrese, Marco Schiavon, Niccolò Daddi, Giampiero Dolci, Franco Stella, Federico Rea
BACKGROUND: Surgical excision with wide margins, prevention of respiratory impairment, and protection of surrounding organs are primary goals in resection and reconstruction of the chest wall. We describe our experience of the use of cadaveric cryopreserved sternal allograft. METHODS: Eighteen patients underwent surgery. Indications for sternectomy were sternal metastases (n = 9), primary chondrosarcoma (n = 4), sternal dehiscence (n = 2), soft tissue sarcoma (n = 1), malignant solitary fibrous tumor (n = 1), and direct involvement of thymic carcinoma (n = 1)...
November 5, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27824983/fit-of-e-max-crowns-fabricated-using-conventional-and-cad-cam-technology-a-comparative-study
#16
Atsushi Miwa, Hidehiro Kori, Yoshihiro Tsukiyama, Rika Kuwatsuru, Yasuyuki Matsushita, Kiyoshi Koyano
PURPOSE: The aim of this study was to examine the fit accuracy of e.max crowns by investigating marginal and internal gaps. MATERIALS AND METHODS: In experiment 1, 60 e.max computer-aided design/computer-assisted manufacture (CAD/CAM) crowns were manufactured. The crowns were fabricated using optical scanning of artificial teeth (Op group) or scanning of a plaster model following a silicone impression (M group). Cement space settings of 90, 120, and 150 μm were applied...
November 2016: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/27805647/effective-method-to-study-the-thickness-dependent-dielectric-functions-of-nanometal-thin-film
#17
Er-Tao Hu, Qing-Yuan Cai, Rong-Jun Zhang, Yan-Feng Wei, Wen-Chao Zhou, Song-You Wang, Yu-Xiang Zheng, Wei Wei, Liang-Yao Chen
A new method for measuring the dielectric functions change with the thickness of nanometal thin films was proposed. To confirm the accuracy and reliability of the method, a nano-thin wedge-shaped gold (Au) film with continuously varied thicknesses was designed and prepared on K9 glass by direct-current-sputtering (DC-sputtering). The thicknesses and the dielectric functions in the wavelength range of 300-1100 nm of the nano-thin Au films were obtained by fitting the ellipsometric parameters with the Drude and critical points model...
November 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27802729/asymmetry-parameter-of-peaked-fano-line-shapes
#18
S Meierott, T Hotz, N Néel, J Kröger
The spectroscopic line shape of electronic and vibrational excitations is ubiquitously described by a Fano profile. In the case of nearly symmetric and peaked Fano line shapes, the fit of the conventional Fano function to experimental data leads to difficulties in unambiguously extracting the asymmetry parameter, which may vary over orders of magnitude without degrading the quality of the fit. Moreover, the extracted asymmetry parameter depends on initially guessed values. Using the spectroscopic signature of the single-Co Kondo effect on Au(110) the ambiguity of the extracted asymmetry parameter is traced to the highly symmetric resonance profile combined with the inevitable scattering of experimental data...
October 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27799540/optimal-stomatal-behavior-with-competition-for-water-and-risk-of-hydraulic-impairment
#19
Adam Wolf, William R L Anderegg, Stephen W Pacala
For over 40 y the dominant theory of stomatal behavior has been that plants should open stomates until the carbon gained by an infinitesimal additional opening balances the additional water lost times a water price that is constant at least over short periods. This theory has persisted because of its remarkable success in explaining strongly supported simple empirical models of stomatal conductance, even though we have also known for over 40 y that the theory is not consistent with competition among plants for water...
October 31, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27796574/clinical-performance-of-screw-retained-and-cemented-implant-supported-zirconia-single-crowns-36-month-results
#20
Claudio Cacaci, Friederike Cantner, Thomas Mücke, Peter Randelzhofer, Jan Hajtó, Florian Beuer
OBJECTIVES: The objective of this clinical study was to evaluate the clinical performance of implant-supported zirconia crowns with a sintered veneering cap. Furthermore, the influence of the type of retention (screw-retained vs cemented single crowns) was analysed. MATERIALS AND METHODS: Fifty-eight patients were accommodated with 114 implants, inserted in the molar and premolar regions. Zirconia-based crowns with a sintered veneering cap were either screw-retained (n = 53) or cemented (n = 61) on the implant...
October 29, 2016: Clinical Oral Investigations
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