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https://www.readbyqxmd.com/read/28106055/rapid-adaptive-phenotypic-change-following-colonization-of-a-newly-restored-habitat
#1
Camilla Lo Cascio Sætre, Charles Coleiro, Martin Austad, Mark Gauci, Glenn-Peter Sætre, Kjetil Lysne Voje, Fabrice Eroukhmanoff
Real-time observation of adaptive evolution in the wild is rare and limited to cases of marked, often anthropogenic, environmental change. Here we present the case of a small population of reed warblers (Acrocephalus scirpaceus) over a period of 19 years (1996-2014) after colonizing a restored wetland habitat in Malta. Our data show a population decrease in body mass, following a trajectory consistent with a population ascending an adaptive peak, a so-called Ornstein-Uhlenbeck process. We corroborate these findings with genetic and ecological data, revealing that individual survival is correlated with body mass, and more than half of the variation in mean population fitness is explained by variation in body mass...
January 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28099086/maximal-heart-rate-declines-linearly-with-age-independent-of-cardiorespiratory-fitness-levels
#2
Cemal Ozemek, Mitchell H Whaley, W Holmes Finch, Leonard A Kaminsky
There have been many conflicting observations between the linear or curvilinear decline in maximal heart rate (HRmax) with age. The aim of this study was to determine if linear or curvilinear equations would better describe the decline in HRmax with age in individuals of differing cardiorespiratory fitness (CRF) levels. Treadmill cardiopulmonary exercise test (CPX) results from participants (1510 men and 1134 women; 18-76 years) free of overt cardiovascular disease were retrospectively examined using cross-sectional and longitudinal study designs...
January 18, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28091875/the-effect-of-veneering-on-the-marginal-fit-of-cad-cam-generated-copy-milled-and-cast-metal-copings
#3
Sabit Melih Ates, Zeynep Yesil Duymus, Ipek Caglar, Bilal Hologlu
OBJECTIVE: This in vitro study investigated the marginal fit of metal and zirconia copings before and after veneering on dies with shoulder/chamfer (s/c) finish lines. MATERIALS AND METHODS: Using CAD/CAM, ten (n = 10) each s/c zirconia (NZ) copings and ten (n = 10) each s/c metal (MM) copings were generated. As controls, ten (n = 10) each s/c zirconia copings were copy-milled (ZZ) and ten (n = 10) each s/c metal copings were cast (CC). The vertical marginal discrepancy of the copings was measured at 20 predefined spots of the circular shoulder and chamfer finish lines in microns (μm) before and after a first and a second veneering firing using a stereomicroscope at ×40 magnification...
January 13, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28089978/rituximab-retreatment-in-rheumatoid-arthritis-in-a-real-life-cohort-data-from-the-cererra-collaboration
#4
Katerina Chatzidionysiou, Elisabeth Lie, Galina Lukina, Merete L Hetland, Ellen-Margrethe Hauge, Karel Pavelka, Cem Gabay, Almut Scherer, Dan Nordström, Helena Canhao, Maria José Santos, Matija Tomsic, Ziga Rotar, M Victoria Hernández, Juan Gomez-Reino, Ioan Ancuta, Tore K Kvien, Ronald van Vollenhoven
OBJECTIVE: Several aspects of rituximab (RTX) retreatment in rheumatoid arthritis (RA) need to be further elucidated. The aim of this study was to describe the effect of repeated courses of RTX on disease activity and to compare 2 retreatment strategies, fixed-interval versus on-flare retreatment, in a large international, observational, collaborative study. METHODS: In the first analysis, patients with RA who received at least 4 cycles with RTX were included. In the second analysis, patients who received at least 1 RTX retreatment and for whom information about the strategy for retreatment was available were identified...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28089333/fit-of-interim-crowns-fabricated-using-photopolymer-jetting-3d%C3%A2-printing
#5
Hang-Nga Mai, Kyu-Bok Lee, Du-Hyeong Lee
STATEMENT OF PROBLEM: The fit of interim crowns fabricated using 3-dimensional (3D) printing is unknown. PURPOSE: The purpose of this in vitro study was to evaluate the fit of interim crowns fabricated using photopolymer-jetting 3D printing and to compare it with that of milling and compression molding methods. MATERIAL AND METHODS: Twelve study models were fabricated by making an impression of a metal master model of the mandibular first molar...
January 12, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28087769/enzyme-efficiency-but-not-thermostability-drives-cefotaxime-resistance-evolution-in-tem-1-%C3%AE-lactamase
#6
Jennifer Knies, Fei Cai, Daniel M Weinreich
A leading intellectual challenge in evolutionary genetics is to identify the specific phenotypes that drive adaptation. Enzymes offer a particularly promising opportunity to pursue this question, because many enzymes' contributions to organismal fitness depend on a comparatively small number of experimentally accessible properties. Moreover, on first principles the demands of enzyme thermostability stand in opposition to the demands of catalytic activity. This observation, coupled with the fact that enzymes are only marginally thermostable, motivates the widely held hypothesis that mutations conferring functional improvement require compensatory mutations to restore thermostability...
January 12, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28074281/one-step-cad-cam-titanium-cranioplasty-after-drilling-template-assisted-resection-of-intraosseous-skull-base-meningioma-technical-note
#7
A Carolus, S Weihe, K Schmieder, C Brenke
INTRODUCTION: Cranial defects following intra-osseous tumor removal may be large and require adequate reconstruction. CAD/CAM implants have been used for years to achieve an optimal cosmetic result. The disadvantage is that such implants require a second surgery. A preoperative virtual planning of resection margins and the simultaneously fabrication of the cranioplasty could be a possibility to subsume the steps tumor resection and cosmetic restoration to a single procedure. METHODS: We present two cases of patients with complex intra-osseous spheno-orbital meningioma...
January 10, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28070978/testing-for-local-adaptation-and-evolutionary-potential-along-altitudinal-gradients-in-rainforest-drosophila-beyond-laboratory-estimates
#8
Eleanor K O'Brien, Megan Higgie, Alan Reynolds, Ary A Hoffmann, Jon R Bridle
Predicting how species will respond to the rapid climatic changes predicted this century is an urgent task. Species distribution models (SDMs) use the current relationship between environmental variation and species' abundances to predict the effect of future environmental change on their distributions. However, two common assumptions of SDMs are likely to be violated in many cases: (i) that the relationship of environment with abundance or fitness is constant throughout a species' range and will remain so in future and (ii) that abiotic factors (e...
January 10, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28068905/g-computation-of-average-treatment-effects-on-the-treated-and-the-untreated
#9
Aolin Wang, Roch A Nianogo, Onyebuchi A Arah
BACKGROUND: Average treatment effects on the treated (ATT) and the untreated (ATU) are useful when there is interest in: the evaluation of the effects of treatments or interventions on those who received them, the presence of treatment heterogeneity, or the projection of potential outcomes in a target (sub-) population. In this paper we illustrate the steps for estimating ATT and ATU using g-computation implemented via Monte Carlo simulation. METHODS: To obtain marginal effect estimates for ATT and ATU we used a three-step approach: fitting a model for the outcome, generating potential outcome variables for ATT and ATU separately, and regressing each potential outcome variable on treatment intervention...
January 9, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28066154/measuring-the-2d-baryon-acoustic-oscillation-signal-of-galaxies-in-wigglez-cosmological-constraints
#10
Samuel R Hinton, Eyal Kazin, Tamara M Davis, Chris Blake, Sarah Brough, Matthew Colless, Warrick J Couch, Michael J Drinkwater, Karl Glazebrook, Russell J Jurek, David Parkinson, Kevin A Pimbblet, Gregory B Poole, Michael Pracy, David Woods
We present results from the 2D anisotropic baryon acoustic oscillation (BAO) signal present in the final data set from the WiggleZ Dark Energy Survey. We analyse the WiggleZ data in two ways: first using the full shape of the 2D correlation function and secondly focusing only on the position of the BAO peak in the reconstructed data set. When fitting for the full shape of the 2D correlation function we use a multipole expansion to compare with theory. When we use the reconstructed data we marginalize over the shape and just measure the position of the BAO peak, analysing the data in wedges separating the signal along the line of sight from that parallel to the line of sight...
February 1, 2017: Monthly Notices of the Royal Astronomical Society
https://www.readbyqxmd.com/read/28063915/univariate-and-bivariate-likelihood-based-meta-analysis-methods-performed-comparably-when-marginal-sensitivity-and-specificity-were-the-targets-of-inference
#11
Issa J Dahabreh, Thomas A Trikalinos, Joseph Lau, Christopher H Schmid
OBJECTIVE: To compare statistical methods for meta-analysis of sensitivity and specificity of medical tests (e.g., diagnostic or screening tests). STUDY DESIGN AND SETTING: We constructed a database of PubMed-indexed meta-analyses of test performance from which 2×2 tables for each included study could be extracted. We re-analyzed the data using univariate and bivariate random effects models fit with inverse variance and maximum likelihood methods. Analyses were performed using both normal and binomial likelihoods to describe within-study variability...
January 4, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28054155/radiological-and-histological-analysis-of-two-replaced-interphalangeal-joints-with-active-subchondral-bone-resorption-in-erosive-hand-osteoarthritis-a-novel-mechanism
#12
Marta Favero, Giorgio Perino, Maria Luisa Valente, Cesare Tiengo, Roberta Ramonda
The aim of this study was to describe the histological features of erosive hand osteoarthritis (EHOA), which is considered an aggressive subset of hand osteoarthritis (OA) characterized by severe local inflammation and degeneration of the distal and proximal interphalangeal joints. Two patients with EHOA underwent replacement with a cement-free press fit ceramic prosthesis of a proximal interphalangeal joint (PIPJ). Clinical and radiological data were collected and histological examination was performed. Radiological examination with histological correlation showed complete erosion of the articular cartilage with focal presence of peripheral fibrocartilaginous resurfacing, sclerosis, and remodeling of the exposed bone, osteoclastic activity with resorptive lacunae in the subchondral bone and around degenerative fibromyxoid pseudocysts, coarse trabeculation of the cancellous bone, and marginal osteophytes...
January 4, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28048105/su-g-bra-17-tracking-multiple-targets-with-independent-motion-in-real-time-using-a-multi-leaf-collimator
#13
Y Ge, P Keall, P Poulsen
PURPOSE: Multiple targets with large intrafraction independent motion are often involved in advanced prostate, lung, abdominal, and head and neck cancer radiotherapy. Current standard of care treats these with the originally planned fields, jeopardizing the treatment outcomes. A real-time multi-leaf collimator (MLC) tracking method has been developed to address this problem for the first time. This study evaluates the geometric uncertainty of the multi-target tracking method. METHODS: Four treatment scenarios are simulated based on a prostate IMAT plan to treat a moving prostate target and static pelvic node target: 1) real-time multi-target MLC tracking; 2) real-time prostate-only MLC tracking; 3) correcting for prostate interfraction motion at setup only; and 4) no motion correction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047415/su-f-j-17-patient-localization-using-mri-guided-soft-tissue-for-head-and-neck-radiotherapy-indication-for-margin-reduction-and-its-feasibility
#14
X Qi, Y Yang, N Jack, A Santhanam, L Yang, A Chen, D Low
PURPOSE: On-board MRI provides superior soft-tissue contrast, allowing patient alignment using tumor or nearby critical structures. This study aims to study H&N MRI-guided IGRT to analyze inter-fraction patient setup variations using soft-tissue targets and design appropriate CTV-to-PTV margin and clinical implication. METHODS: 282 MR images for 10 H&N IMRT patients treated on a ViewRay system were retrospectively analyzed. Patients were immobilized using a thermoplastic mask on a customized headrest fitted in a radiofrequency coil and positioned to soft-tissue targets...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046438/we-ab-207b-11-optimizing-tumor-control-probability-in-radiation-therapy-treatment-application-to-hdr-cervical-cancer
#15
E Lee, F Yuan, A Templeton, R Yao, J Chu
PURPOSE: The ultimate goal of radiotherapy treatment planning is to find a treatment that will yield a high tumor-control-probability(TCP) with an acceptable normal-tissue-complication probability(NTCP). Yet most treatment planning today is not based upon optimization of TCPs and NTCPs, but rather upon meeting physical dose and volume constraints defined by the planner. We design treatment plans that optimize TCP directly and contrast them with the clinical dose-based plans. PET image is incorporated to evaluate gain in TCP for dose escalation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045961/noseband-use-in-equestrian-sports-an-international-study
#16
Orla Doherty, Vincent Casey, Paul McGreevy, Sean Arkins
Nosebands are used by riders to prevent the horse from opening its mouth, to increase control and, in some cases, to comply with the competition rules. While equestrian texts traditionally recommend that two adult human fingers should be able to fit under a fastened noseband, noseband tightness levels are not, in general, regulated in competition. Possible detrimental consequences for the horse, of excessively tight nosebands, include discomfort, pain or tissue damage. The current study investigated noseband usage in equestrian competition...
2017: PloS One
https://www.readbyqxmd.com/read/28043069/comparison-of-multivariate-poisson-lognormal-spatial-and-temporal-crash-models-to-identify-hot-spots-of-intersections-based-on-crash-types
#17
Wen Cheng, Gurdiljot Singh Gill, Ravi Dasu, Meiquan Xie, Xudong Jia, Jiao Zhou
Most of the studies are focused on the general crashes or total crash counts with considerably less research dedicated to different crash types. This study employs the Systemic approach for detection of hotspots and comprehensively cross-validates five multivariate models of crash type-based HSID methods which incorporate spatial and temporal random effects. It is anticipated that comparison of the crash estimation results of the five models would identify the impact of varied random effects on the HSID. The data over a ten year time period (2003-2012) were selected for analysis of a total 137 intersections in the City of Corona, California...
December 30, 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28031791/trapped-in-the-web-of-water-groundwater-fed-springs-are-island-like-ecosystems-for-the-meiofauna
#18
Simone Fattorini, Paulo A V Borges, Barbara Fiasca, Diana M P Galassi
We investigated whether the equilibrium theory of island biogeography (ETIB) can be applied to the meiofauna of groundwater-fed springs. We tested whether copepod species richness was related with spring area, discharge, and elevation. Additionally, five hypotheses are tested based on species distribution patterns, dispersal ability, and life-history characteristics of several guilds (stygobiotic, nonstygobiotic, cold stenotherm, and noncold stenotherm species). Thirty springs in the central Apennines (Italy) were considered...
December 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28028693/a-study-of-coronary-bifurcation-shape-in-a-normal-population
#19
Pau Medrano-Gracia, John Ormiston, Mark Webster, Susann Beier, Chris Ellis, Chunliang Wang, Örjan Smedby, Alistair Young, Brett Cowan
During percutaneous coronary intervention, stents are placed in narrowings of the arteries to restore normal blood flow. Despite improvements in stent design, deployment techniques and drug-eluting coatings, restenosis and stent thrombosis remain a significant problem. Population stent design based on statistical shape analysis may improve clinical outcomes. Computed tomographic (CT) coronary angiography scans from 211 patients with a zero calcium score, no stenoses and no intermediate artery, were used to create statistical shape models of 446 major coronary artery bifurcations (left main, first diagonal and obtuse marginal and right coronary crux)...
December 27, 2016: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28025321/national-income-inequality-and-ineffective-health-insurance-in-35-low-and-middle-income-countries
#20
Francisco N Alvarez, Abdulrahman M El-Sayed
Global health policy efforts to improve health and reduce financial burden of disease in low- and middle-income countries (LMIC) has fuelled interest in expanding access to health insurance coverage to all, a movement known as Universal Health Coverage (UHC). Ineffective insurance is a measure of failure to achieve the intended outcomes of health insurance among those who nominally have insurance. This study aimed to evaluate the relation between national-level income inequality and the prevalence of ineffective insurance...
December 26, 2016: Health Policy and Planning
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