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https://www.readbyqxmd.com/read/28221737/feasibility-of-multiple-breath-washout-measurements-in-infants-with-bronchiolitis-a-pilot-study
#1
Patrick Stafler, Sigal Weinreb, Huda Mussaffi, Meir Mei-Zahav, Dario Prais, Guy Steuer, Ophir Bar-On, Moshe Hoshen, Hannah Blau
BACKGROUND: Lung clearance index (LCI) reflects ventilation inhomogeneity and is raised in obstructive airway disease. Feasibility of multiple breath washout (MBW) measurement during acute lung disease in infants is unknown. As a further measure of disease, exhaled nitric oxide (eNO) may paradoxically decrease in acute bronchiolitis. We hypothesized that MBW measurements were attainable in infants with bronchiolitis and that LCI was raised and eNO reduced, compared to normal controls...
February 21, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28221351/imaging-quantum-stereodynamics-through-fraunhofer-scattering-of-no-radicals-with-rare-gas-atoms
#2
Jolijn Onvlee, Sean D S Gordon, Sjoerd N Vogels, Thomas Auth, Tijs Karman, Bethan Nichols, Ad van der Avoird, Gerrit C Groenenboom, Mark Brouard, Sebastiaan Y T van de Meerakker
Stereodynamics describes how the vector properties of molecules, such as the directions in which they move and the axes about which they rotate, affect the probabilities (or cross-sections) of specific processes or transitions that occur on collision. The main aspects of stereodynamics in inelastic atom-molecule collisions can often be understood from classical considerations, in which the particles are represented by billiard-ball-like hard objects. In a quantum picture, however, the collision is described in terms of matter waves, which can also scatter into the region of the geometrical shadow of the object and reveal detailed information on the pure quantum-mechanical contribution to the stereodynamics...
March 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28221040/magnetic-fullerene-dna-hyaluronic-acid-nanovehicles-with-magnetism-reduction-dual-responsive-triggered-release
#3
Ling Wang, Yitong Wang, Jingcheng Hao, Shuli Dong
We create the dual-responsive nanovehicle that can effectively combine and abundantly utilize magnetic and glutathione (GSH)-reductive triggers to control the drug delivery and achieve more intelligent and powerful targeting. In the nanovehicles, paramagnetic fullerene (C60@CTAF) was prepared via one-step modification of fullerene with magnetic surfactant CTAF by hydrophobic interaction for the first time. The perfect conjugation of C60 and CTAF increased the solubility or dispersity of fullerenes and qualify CTAF with more powerful assembly capability with DNA...
February 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28220843/dusp1-promoter-methylation-in-peripheral-blood-leukocyte-is-associated-with-triple-negative-breast-cancer-risk
#4
Jing Li, Yanbo Chen, Hongyuan Yu, Jingshen Tian, Fengshun Yuan, Jialong Fan, Yupeng Liu, Lin Zhu, Fan Wang, Yashuang Zhao, Da Pang
DNA methylation is one of the most common epigenetic alterations, providing important information regarding cancer risk and prognosis. A case-control study (423 breast cancer cases, 509 controls) and a case-only study (326 cases) were conducted to evaluate the association of DUSP1 promoter methylation with breast cancer risk and clinicopathological characteristics. No significant association between DUSP1 methylation in peripheral blood leukocyte (PBL) DNA and breast cancer risk was observed. DUSP1 methylation was significantly associated with ER/PR-negative status; in particular, triple-negative breast cancer patients showed the highest frequency of DUSP1 methylation in both tumour DNA and PBL DNA...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220709/ten-year-old-girl-with-abdominal-pain-irregular-breathing-and-tachycardia
#5
April Edwards, Stephanie Permar, Scott Buck, Ravi Jhaveri
No abstract text is available yet for this article.
March 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28220587/the-relationship-between-different-dimensions-of-alcohol-use-and-the-burden-of-disease-an-update
#6
REVIEW
Jürgen Rehm, Gerhard E Gmel, Gerrit Gmel, Omer S M Hasan, Sameer Imtiaz, Svetlana Popova, Charlotte Probst, Michael Roerecke, Robin Room, Andriy V Samokhvalov, Kevin D Shield, Paul A Shuper
BACKGROUND AND AIMS: Alcohol use is a major contributor to injuries, mortality and the burden of disease. This review updates knowledge on risk relations between dimensions of alcohol use and health outcomes to be used in global and national Comparative Risk Assessments (CRAs). METHODS: Systematic review of reviews and meta-analyses on alcohol consumption and health outcomes attributable to alcohol use. For dimensions of exposure: volume of alcohol use, blood alcohol concentration and patterns of drinking, in particular heavy drinking occasions were studied...
February 20, 2017: Addiction
https://www.readbyqxmd.com/read/28220574/selective-use-of-the-electrocardiogram-in-pediatric-preparticipation-athletic-examinations-among-pediatric-primary-care-providers
#7
Bradley C Clark, Joshua M Hayman, Charles I Berul, Kristin M Burns, Jonathan R Kaltman
OBJECTIVES: Recent literature examining insurance administrative data suggests that a selective approach, with concurrent history and physical exam (H&P), for obtaining an electrocardiogram (ECG) as a part of a preparticipation examination (PPE) for pediatric athletes is commonly used in the primary care setting demonstrating a high rate of disease detection. We sought to understand practice patterns of providers with regard to usage of ECG as a part of PPE. METHODS: Utilizing an online survey, we queried primary care providers regarding their practice patterns, rationale, and concerns regarding use of ECGs as a part of the PPE...
February 21, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28220360/oral-histoplasmosis
#8
Gillian A Folk, Brenda L Nelson
A 44-year-old female presented to her general dentist with the chief complaint of a painful mouth sore of 2 weeks duration. Clinical examination revealed an irregularly shaped ulcer of the buccal and lingual attached gingiva of the anterior mandible. A biopsy was performed and microscopic evaluation revealed histoplasmosis. Histoplasmosis, caused by Histoplasma capsulate, is the most common fungal infection in the United States. Oral lesions of histoplasmosis are generally associated with the disseminated form of histoplasmosis and may present as a fungating or ulcerative lesion of the oral mucosa...
February 20, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28220335/multivariate-evaluation-of-thyroid-imaging-reporting-and-data-system-ti-rads-in-diagnosis-malignant-thyroid-nodule-application-to-pca-and-pls-da-analysis
#9
Tan Zhang, Fangxuan Li, Jiali Mu, Juntian Liu, Sheng Zhang
OBJECTIVE: To explore the significance of ultrasonic features in differential diagnosis of thyroid nodules via combining the thyroid imaging reporting and data system (TI-RADS) and multivariate statistical analysis. METHODS: Patients who received surgical treatment and was diagnosed with single thyroid nodule by postoperative pathology and preoperative ultrasound were enrolled in this study. Multivariate analysis was applied to assess the significant ultrasonic features which correlated with identifying benign or malignance and grading the TI-RADS classification of thyroid nodule...
February 20, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28219424/health-risk-assessment-of-china-s-main-air-pollutants
#10
Jian Sun, Tiancai Zhou
BACKGROUND: With the rapid development of China's economy, air pollution has attracted public concern because of its harmful effects on health. METHODS: The source apportioning of air pollution, the spatial distribution characteristics, and the relationship between atmospheric contamination, and the risk of exposure were explored. The in situ daily concentrations of the principal air pollutants (PM2.5, PM10, SO2, NO2, CO and O3) were obtained from 188 main cities with many continuous air-monitoring stations across China (2014 and 2015)...
February 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28218688/determinants-of-health-care-services-utilization-among-first-generation-afghan-migrants-in-istanbul
#11
Qais Alemi, Carl Stempel, Patrick Marius Koga, Valerie Smith, Didem Danis, Kelly Baek, Susanne Montgomery
There is insufficient empirical evidence on the correlates of health care utilization of irregular migrants currently living in Turkey. The aim of this study was to identify individual level determinants associated with health service and medication use. One hundred and fifty-five Afghans completed surveys assessing service utilization including encounters with primary care physicians and outpatient specialists in addition to the use of prescription and nonprescription medicines. Multivariate logistic regression analyses were employed to examine associations between service use and a range of predisposing, enabling, and perceived need factors...
February 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28218485/mechanically-milled-irregular-zinc-nanoparticles-for-printable-bioresorbable-electronics
#12
Bikram K Mahajan, Xiaowei Yu, Wan Shou, Heng Pan, Xian Huang
Bioresorbable electronics is predominantly realized by complex and time-consuming anhydrous fabrication processes. New technology explores printable methods using inks containing micro- or nano-bioresorbable particles (e.g., Zn and Mg). However, these particles have seldom been obtained in the context of bioresorbable electronics using cheap, reliable, and effective approaches with limited study on properties essential to printable electronics. Here, irregular nanocrystalline Zn with controllable sizes and optimized electrical performance is obtained through ball milling approach using polyvinylpyrrolidone (PVP) as a process control agent to stabilize Zn particles and prevent cold welding...
February 20, 2017: Small
https://www.readbyqxmd.com/read/28218397/segmentation-of-digitized-histological-sections-for-quantification-of-the-muscularized-vasculature-in-the-mouse-hind-limb
#13
Yiwen Xu, J Geoffrey Pickering, Zengxuan Nong, Aaron D Ward
Immunohistochemical tissue staining enhances microvasculature characteristics, including the smooth muscle in the medial layer of the vessel walls that is responsible for regulation of blood flow. The vasculature can be imaged in a comprehensive fashion using whole-slide scanning. However, since each such image potentially contains hundreds of small vessels, manual vessel delineation and quantification is not practically feasible. In this work, we present a fully automatic segmentation and vasculature quantification algorithm for whole-slide images...
February 20, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28218244/transformation-from-slip-to-plastic-flow-deformation-mechanism-during-tensile-deformation-of-zirconium-nanocontacts
#14
Kohei Yamada, Tokushi Kizuka
Various types of nanometer-sized structures have been applied to advanced functional and structural devices. Inherent structures, thermal stability, and properties of such nanostructures are emphasized when their size is decreased to several nanometers, especially, to several atoms. In this study, we observed the atomistic tensile deformation process of zirconium nanocontacts, which are typical nanostructures used in connection of nanometer-sized wires, transistors, and diodes, memory devices, and sensors, by in situ transmission electron microscopy...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217994/structure-of-a-stable-g-hairpin
#15
Martin Gajarsky, Martina Lenarcic Zivkovic, Petr Stadlbauer, Bruno Pagano, Radovan Fiala, Jussara Amato, Lubomir Tomaska, Jiri Sponer, Janez Plavec, Lukas Trantirek
In this study, we report the first atomic resolution structure of a stable G-hairpin formed by a natively occurring DNA sequence. An 11-nt-long G-rich DNA oligonucleotide, 5'-d(GTGTGGGTGTG)-3', corresponding to the most abundant sequence motif in irregular telomeric DNA from Saccharomyces cerevisiae (yeast), is demonstrated to adopt a novel type of mixed parallel/antiparallel fold-back DNA structure, which is stabilized by dynamic G:G base pairs that transit between N1-carbonyl symmetric and N1-carbonyl, N7-amino base-pairing arrangements...
February 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28216321/effects-of-dmso-on-a-rabbit-ear-hypertrophic-scar-model-a-controlled-randomized-experimental-study
#16
Elif Sari, Bulent Bakar, Gungor Cagdas Dincel, Fatma Azize Budak Yildiran
Dimethyl sulfoxide (DMSO) is an anti-inflammatory, antibacterial, analgesic drug widely used to treat several diseases as reported in the literature. It has a detractive effect on collagen deposition in the abnormal tissue. This study aimed to investigate the possible therapeutic effects of DMSO on hypertrophic scar formation in rabbits. Twenty-four New Zealand male albino rabbits were randomly divided into four groups: control, sham, DMSO, and TRA (triamcinolone acetonide). Except the control group, punch biopsy defects were created on each animal's right ear...
January 23, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28215817/free-dermal-fat-graft-reconstruction-of-the-head-and-neck-an-alternate-reconstructive-option
#17
Adam Honeybrook, Sanjay M Athavale, Sanjeet V Rangarajan, Sarah L Rohde, James L Netterville
OBJECTIVES: Ablative procedures of the head and neck often result in significant facial and cervical irregularities and cosmetic asymmetry. The deformity resulting from ablative procedures of the head and neck is a significant source of cosmetic morbidity and postoperative dissatisfaction. Reconstruction of post-ablative defects in the head and neck can employ a broad range of techniques, ranging from primary closure to free tissue transfer. The free dermal fat graft (FDFG) is one such option and has been used to repair volume defects of varying sizes after common head and neck procedures such as parotidectomy...
January 27, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28215622/on-the-neural-basis-of-sensory-weighting-alpha-beta-and-gamma-modulations-during-complex-movements
#18
Nicolas Lebar, Jérémy Danna, Simon Moré, Laurence Mouchnino, Jean Blouin
Previous studies have revealed that visual and somatosensory information is processed as a function of its relevance during movement execution. We thus performed spectral decompositions of ongoing neural activities within the somatosensory and visual areas while human participants performed a complex visuomotor task. In this task, participants followed the outline of irregular polygons with a pen-controlled cursor. At unpredictable times, the motion of the cursor deviated 120° with respect to the actual pen position creating an incongruence between visual and somatosensory inputs, thus increasing the importance of visual feedback to control the movement as suggested in previous studies...
February 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28215018/responses-of-wintering-geese-to-the-designation-of-goose-foraging-areas-in-the-netherlands
#19
Kees Koffijberg, Hans Schekkerman, Henk van der Jeugd, Menno Hornman, Erik van Winden
The Netherlands is important for wintering migratory herbivorous geese, numbers of which have rapidly increased, leading to conflict with agriculture. In 2005/2006, a new goose management policy aimed to limit compensation payments to farmers by concentrating foraging geese in 80 000 ha of designated 'go' areas-where farmers received payment to accommodate them-and scaring geese from 'no go' areas elsewhere. Monthly national counts of four abundant goose species during 10 years prior to the new policy and in 8 years following implementation found that 57% of all goose days were spent within 'go' areas under the new management, the same as prior to implementation...
March 2017: Ambio
https://www.readbyqxmd.com/read/28214717/an-interactive-medical-image-segmentation-framework-using-iterative-refinement
#20
Pratik Kalshetti, Manas Bundele, Parag Rahangdale, Dinesh Jangra, Chiranjoy Chattopadhyay, Gaurav Harit, Abhay Elhence
Segmentation is often performed on medical images for identifying diseases in clinical evaluation. Hence it has become one of the major research areas. Conventional image segmentation techniques are unable to provide satisfactory segmentation results for medical images as they contain irregularities. They need to be pre-processed before segmentation. In order to obtain the most suitable method for medical image segmentation, we propose MIST (Medical Image Segmentation Tool), a two stage algorithm. The first stage automatically generates a binary marker image of the region of interest using mathematical morphology...
February 13, 2017: Computers in Biology and Medicine
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