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Ocular Tuberculosis

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https://www.readbyqxmd.com/read/27904945/-sarcoidosis-and-uveitis-an-update
#1
REVIEW
J G Garweg
Ocular involvement in sarcoidosis is present in up to one third of patients and is frequently manifested before the underlying systemic disease has been diagnosed. With a view to the therapeutic consequences an early diagnosis of the underlying disease is advantageous. In cases of visual loss early diagnostic measures include invasive procedures, such as ultrasound-guided bronchoalveolar lavage and transbronchial biopsy, if nodular conjunctival or cutaneous manifestations which would confirm the diagnosis are not present...
November 30, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27901620/etiology-and-clinical-features-of-ocular-inflammatory-diseases-in-a-tertiary-referral-centre-in-sydney-australia
#2
Sophia L Zagora, Richard Symes, Aaron Yeung, Will Yates, Denis Wakefield, Peter J McCluskey
PURPOSE: To report the pattern of uveitis in patients attending a tertiary uveitis service in Sydney, Australia. METHODS: The charts of patients seen between January 2009 and December 2015 were retrospectively reviewed. Data pertaining to patient demographics, eye examination on presentation, work-up and final diagnoses were collected. RESULTS: The total number of patients with uveitis seen over this period was 1165. There were 650 males (56%) and 515 females (44%)...
November 30, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27896896/presumed-tuberculous-uveitis-in-non-endemic-country-for-tuberculosis-case-series-from-a-new-zealand-tertiary-uveitis-clinic
#3
Ken K Ng, Mitzi Nisbet, Erika M Damato, Joanne L Sims
BACKGROUND: To describe the clinical spectrum of presumed tuberculous (TB) uveitis in a developed, non-endemic country of high immigrant population. DESIGN: Retrospective review of a consecutive case series. PARTICIPANTS: All 39 patients diagnosed with presumed TB uveitis at the tertiary uveitis service in Auckland from 2007 to 2014. METHODS: Clinical chart review. MAIN OUTCOME MEASURES: Patient demographics, risk factors, ophthalmic manifestations, management and outcome...
November 28, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27888495/an-unusual-presentation-of-intraocular-tuberculosis-in-a-monocular-patient-clinicopathological-correlation
#4
Kanika Aggarwal, Aniruddha Agarwal, Shobha Sehgal, Suryaprakash Sharma, Nirbhai Singh, Kusum Sharma, Ramanuj Samanta, Alessandro Invernizzi, Aman Sharma, Vishali Gupta
BACKGROUND: Lack of uniform diagnostic criteria often poses a challenge in the diagnosis and management of tubercular uveitis. The index case describes an unusual presentation of tubercular panuveitis initially misdiagnosed as sympathetic ophthalmia, where the appropriate diagnosis was made using various imaging and laboratory investigations. RESULTS: A 52-year-old Indian woman underwent multimodal imaging, extensive clinical and laboratory work-up, and analysis of microbiological and histopathological specimens...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/27849414/clinical-features-and-complications-of-scleritis-in-chinese-patients
#5
Peizeng Yang, Zi Ye, Jihong Tang, Liping Du, Qingyun Zhou, Jian Qi, Liang Liang, Lili Wu, Chaokui Wang, Mei Xu, Yuan Tian, Aize Kijlstra
PURPOSE: To characterize the clinical features of scleritis in Chinese patients. METHODS: The history, demographics, ocular findings, auxiliary examination findings, complications, systemic diseases and therapeutic effects were analyzed retrospectively. RESULTS: The study included 124 male and 169 female patients with scleritis. Anterior and posterior scleritis were, respectively, found in 243 and 42 patients. The other eight patients had both anterior and posterior involvement...
November 16, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27849401/looking-for-ocular-tuberculosis-prevalence-and-clinical-manifestations-of-patients-with-uveitis-and-positive-quantiferon-%C3%A2-tb-gold-test
#6
Kessara Pathanapitoon, Paradee Kunavisarut, Wasna Sirirungsi, Aniki Rothova
PURPOSE: To report on the prevalence of ocular TB and positive QuantiFERON(®)-TB Gold (QFT-G) test in uveitis patients and describe their clinical manifestations. METHODS: We performed a prospective study of 108 new human immunodeficiency virus-negative uveitis patients. All patients underwent a tailored screening protocol for uveitis and received QFT-G test and tuberculin skin tests (TST). RESULTS: QFT-G test was positive in 39/108 (36%) of patients, while TST ≥15 mm was positive in 16/108 (15%) patients...
November 16, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27815270/controversies-in-ocular-tuberculosis
#7
REVIEW
Marcus Ang, Soon-Phaik Chee
Ocular tuberculosis still remains a presumptive, clinical diagnosis in the presence of supportive clinical signs and investigations, while in the absence of other possible causes of uveitis. The purpose of this review is to discuss three controversies of ocular tuberculosis today. First, it is unclear from many reports on how the diagnosis of ocular tuberculosis was defined, and if they included 'probable' or 'possible' diagnoses. Thus, there is a need to standardise the terminology used for ocular tuberculosis to allow for comparisons among studies...
November 4, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27785746/bilateral-multiple-choroidal-granulomas-and-systemic-vasculitis-as-presenting-features-of-tuberculosis-in-an-immunocompetent-patient
#8
Nitin Kumar, Sridharan Sudharshan, Sudha K Ganesh, Gopal Lingam, Jyotirmay Biswas
BACKGROUND: Multiple choroidal granulomas are a rare presentation of tuberculosis. Choroidal granulomas in immunocompetent patients can pose difficulty in diagnosis as in most cases systemic examination may not reveal any evidence of tuberculosis. We report a case of bilateral multiple choroidal granulomas with systemic vasculitis-like features and disseminated tuberculosis in an immunocompetent patient without pulmonary involvement. FINDINGS: A 26-year-old male Indian patient presented with bilateral blurred vision and systemic illness with vasculitis-like features...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/27726520/multimodal-imaging-in-ocular-tuberculosis
#9
Aniruddha Agarwal, Sarakshi Mahajan, Moncef Khairallah, Padmamalini Mahendradas, Amod Gupta, Vishali Gupta
Intraocular tuberculosis presents a diagnostic challenge because of its protean clinical manifestations. Thus, it becomes imperative to distinguish chorioretinal inflammation due to tuberculosis from other infectious as well as non-infectious posterior uveitis since the clinical manifestations of these entities may be quite similar. With advancing technology, a number of novel imaging modalities are available today that enable in vivo near-histologic assessment of the chorioretinal tissue, greatly aiding the clinician in establishing a diagnosis and monitoring the therapeutic response of tubercular lesions...
October 11, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27646473/latent-tuberculosis-related-scleritis-a-case-report
#10
Houssaine Ait Lhaj, Amine Benjelloun, Youssef Bouia, Youssef Bennouk, Yassine Mouzari, Youssef El Kamouni, Mohamed Kriet
BACKGROUND: Scleritis is a painful inflammatory process centered in the sclera that may involve the cornea and the underlying uvea. The etiology is commonly idiopathic or autoimmune but some cases are associated with systemic infection such as tuberculosis. CASE PRESENTATION: In this report, we describe an unusual case of a female Moroccan patient who had a long history of bilateral recurrent scleritis associated with peripheral keratopathy and anterior uveitis...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/27611434/linezolid-associated-optic-neuropathy-in-drug-resistant-tuberculosis-patients-in-mumbai-india
#11
Salil Mehta, Mrinalini Das, Chinmay Laxmeshwar, Sylvie Jonckheere, Sein Sein Thi, Petros Isaakidis
BACKGROUND: Patients on linezolid-containing drug-resistant TB (DR-TB) regimen often develop adverse-events, particularly peripheral and optic neuropathy. Programmatic data and experiences of linezolid-associated optic neuropathy from high DR-TB burden settings are lacking. The study aimed to determine the frequency of and risk-factors associated with linezolid-associated optic neuropathy and document the experiences related to treatment/care of DR-TB patients on linezolid-containing regimens...
2016: PloS One
https://www.readbyqxmd.com/read/27542302/adalimumab-for-prevention-of-uveitic-flare-in-patients-with-inactive-non-infectious-uveitis-controlled-by-corticosteroids-visual-ii-a-multicentre-double-masked-randomised-placebo-controlled-phase-3-trial
#12
RANDOMIZED CONTROLLED TRIAL
Quan Dong Nguyen, Pauline T Merrill, Glenn J Jaffe, Andrew D Dick, Shree Kumar Kurup, John Sheppard, Ariel Schlaen, Carlos Pavesio, Luca Cimino, Joachim Van Calster, Anne A Camez, Nisha V Kwatra, Alexandra P Song, Martina Kron, Samir Tari, Antoine P Brézin
BACKGROUND: Non-infectious uveitis is a potentially sight-threatening ocular disorder caused by chronic inflammation and its complications. Therapeutic success is limited by systemic adverse effects associated with long-term corticosteroid and immunomodulator use if topical medication is not sufficient to control the inflammation. We aimed to assess the efficacy and safety of adalimumab in patients with inactive, non-infectious uveitis controlled by systemic corticosteroids. METHODS: We did this multicentre, double-masked, randomised, placebo-controlled phase 3 trial at 62 study sites in 21 countries in the USA, Canada, Europe, Israel, Australia, and Latin America...
September 17, 2016: Lancet
https://www.readbyqxmd.com/read/27541808/clinical-patterns-and-causes-of-uveitis-in-a-referral-eye-clinic-in-qatar
#13
Zamzam Mohammed Al-Baker, Bahram Bodaghi, Shaukat Ayub Khan
PURPOSE: To determine the patterns and causes of uveitis in a referral eye clinic in Qatar. METHODS: A retrospective study was conducted on all cases of uveitis that presented to the Uveitis Clinic at Hamad Medical Corporation from March 2007 to February 2011. All patients had detailed ocular, medical examination, and uveitis work up. RESULTS: The study included 310 patients. Anterior uveitis was noted in 53.2% of cases (165/310), followed by panuveitis 16...
August 19, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27508140/clinical-predictors-of-streptomycin-vestibulotoxicity
#14
Miraj Ahmed, Anupam Mishra, Kamal Kumar Sawlani, Veerendra Verma, Rajiv Garg, Hitendra Prakash Singh, Sunil Kumar
The Global tuberculosis control is challenged with a growing resistance to antitubercular treatment (ATT) culminating in resistant (MDR/XDR) strains; an important factor being premature withdrawal of streptomycin owing to its morbidity particularly nephrotoxicity and cochleotoxicity as guidelines for their prevention exist. An attempt is made here to address the least recognized and most debilitating vestibular toxic effects of streptomycin and defining a vestibular-protocol for its early detection and progression...
September 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27470062/anti-tnf%C3%AE-treatment-for-hla-b27-positive-ankylosing-spondylitis-related-uveitis
#15
Mirinae Kim, Jae-Yon Won, Seung Yong Choi, Ji Hyeon Ju, Young-Hoon Park
PURPOSE: To assess the long-term efficacy of the most widely used anti-tumor necrosis factor alpha (TNFα) agents for treatment of HLA-B27-positive ankylosing spondylitis (AS)-related uveitis. DESIGN: Retrospective cohort study. METHODS: The medical records of 143 patients with HLA-B27-positive AS who visited Seoul St. Mary's Hospital and were taking an anti-TNFα agent for at least 1 year were studied. Subjects were divided into 3 groups according to anti-TNFα treatment: Group 1 (infliximab, 66), Group 2 (adalimumab, 45), and Group 3 (etanercept, 32)...
October 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27467180/a-focus-on-the-epidemiology-of-uveitis
#16
Theodora Tsirouki, Anna Dastiridou, Chrysanthos Symeonidis, Ourania Tounakaki, Irini Brazitikou, Christos Kalogeropoulos, Sofia Androudi
PURPOSE: Uveitis is a common, sight-threatening inflammatory ocular disease and includes multiple heterogeneous clinical entities. The prevalence of various types of uveitis depends upon multiple factors, such as age, sex, race, geographic distribution, environmental influence, genetics, and social habits. Epidemiologic research of uveitis is necessary to understand the etiology and immunopathogenesis of this group of diseases. The present study attempts to concentrate on the most recent information on the epidemiology of uveitis and compare it with previous knowledge...
July 28, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27437932/observed-patterns-of-systemic-disease-on-pet-ct-scan-in-patients-with-presumed-ocular-tuberculosis-findings-and-hypotheses
#17
Salil Mehta
PURPOSE: To report the clinical, investigational and PET/CT scan findings of patients with presumed ocular tuberculosis and suggest a hypotheses for the pathogenesis. METHODS: Retrospective case review. Included were 10 males and 17 females with an age range: 23-71 years. RESULTS: Clinical findings include granulomatous or non-granulomatous anterior uveitis, intermediate uveitis, panuveitis, vasculitis, and multifocal serpiginous-like choroidopathy...
July 20, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27437721/clinical-profile-of-patients-with-tubercular-subretinal-abscess-in-a-tertiary-eye-care-center-in-southern-india
#18
Parthopratim Dutta Majumder, Jyotirmay Biswas, Nishat Bansal, Avirupa Ghose, Hitesh Sharma
PURPOSE: To retrospectively analyze clinical features, laboratory investigations, treatment and visual outcomes in patients with tubercular subretinal abscess. METHODS: A total of 12 eyes of 12 patients receiving a diagnosis of subretinal abscess, between 2004 and 2014, were included for this retrospective study. RESULTS: The mean age of the presentation was 29.75 ± 16.72 years (range: 14-62 years) and seven (58.3%) were male. The most common anterior segment presentation was anterior uveitis (75%)...
July 20, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27420799/recurrent-bilateral-anterior-uveitis-with-kikuchi-fujimoto-disease
#19
Marta Gómez-Mariscal, Andrea Oleñik, Pablo Arriba-Palomero, Mónica García-Cosio, Francisco J Muñoz-Negrete
PURPOSE: To report an uncommon case of Kikuchi-Fujimoto disease-associated-uveitis. METHODS: A 31-year-old Caucasian woman with cervical lymphadenitis and Kikuchi-Fujimoto disease recently confirmed by biopsy, complained about unilateral blurry vision. Differential diagnoses, including non-Hodgkin lymphoma, tuberculosis, sarcoidosis, Behçet disease, rheumatoid arthritis, and juvenile idiopathic arthritis was performed. We undertook a review of other similar cases found in the literature...
July 15, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27413507/bilateral-presumed-tuberculous-choroiditis
#20
Naseh Mohammadi, Fariba Ghassemi, Esfandiar Shojaei, Pardis Moradnejad
PURPOSE: To describe a case of bilateral presumed tuberculous choroiditis which resolved promptly with a short course of antituberculous therapy. CASE REPORT: A 44-year-old lady presented with bilateral visual loss of 8 months'duration. Considering the presence of pan-uveitis, severe macular edema, multifocal leakage on fluorescein angiography, positive tuberculin skin test, and after excluding other diseases, she underwent anti-tuberculous therapy (ATT) for disseminated choroiditis due to presumed ocular tuberculosis...
April 2016: Journal of Ophthalmic & Vision Research
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