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Ocular Tuberculosis

Aniruddha Agarwal, Sarakshi Mahajan, Moncef Khairallah, Padmamalini Mahendradas, Amod Gupta, Vishali Gupta
Intraocular tuberculosis presents a diagnostic challenge because of its protean clinical manifestations. Thus, it becomes imperative to distinguish chorioretinal inflammation due to tuberculosis from other infectious as well as non-infectious posterior uveitis since the clinical manifestations of these entities may be quite similar. With advancing technology, a number of novel imaging modalities are available today that enable in vivo near-histologic assessment of the chorioretinal tissue, greatly aiding the clinician in establishing a diagnosis and monitoring the therapeutic response of tubercular lesions...
October 11, 2016: Ocular Immunology and Inflammation
Houssaine Ait Lhaj, Amine Benjelloun, Youssef Bouia, Youssef Bennouk, Yassine Mouzari, Youssef El Kamouni, Mohamed Kriet
BACKGROUND: Scleritis is a painful inflammatory process centered in the sclera that may involve the cornea and the underlying uvea. The etiology is commonly idiopathic or autoimmune but some cases are associated with systemic infection such as tuberculosis. CASE PRESENTATION: In this report, we describe an unusual case of a female Moroccan patient who had a long history of bilateral recurrent scleritis associated with peripheral keratopathy and anterior uveitis...
2016: BMC Research Notes
Salil Mehta, Mrinalini Das, Chinmay Laxmeshwar, Sylvie Jonckheere, Sein Sein Thi, Petros Isaakidis
BACKGROUND: Patients on linezolid-containing drug-resistant TB (DR-TB) regimen often develop adverse-events, particularly peripheral and optic neuropathy. Programmatic data and experiences of linezolid-associated optic neuropathy from high DR-TB burden settings are lacking. The study aimed to determine the frequency of and risk-factors associated with linezolid-associated optic neuropathy and document the experiences related to treatment/care of DR-TB patients on linezolid-containing regimens...
2016: PloS One
Quan Dong Nguyen, Pauline T Merrill, Glenn J Jaffe, Andrew D Dick, Shree Kumar Kurup, John Sheppard, Ariel Schlaen, Carlos Pavesio, Luca Cimino, Joachim Van Calster, Anne A Camez, Nisha V Kwatra, Alexandra P Song, Martina Kron, Samir Tari, Antoine P Brézin
BACKGROUND: Non-infectious uveitis is a potentially sight-threatening ocular disorder caused by chronic inflammation and its complications. Therapeutic success is limited by systemic adverse effects associated with long-term corticosteroid and immunomodulator use if topical medication is not sufficient to control the inflammation. We aimed to assess the efficacy and safety of adalimumab in patients with inactive, non-infectious uveitis controlled by systemic corticosteroids. METHODS: We did this multicentre, double-masked, randomised, placebo-controlled phase 3 trial at 62 study sites in 21 countries in the USA, Canada, Europe, Israel, Australia, and Latin America...
September 17, 2016: Lancet
Zamzam Mohammed Al-Baker, Bahram Bodaghi, Shaukat Ayub Khan
PURPOSE: To determine the patterns and causes of uveitis in a referral eye clinic in Qatar. METHODS: A retrospective study was conducted on all cases of uveitis that presented to the Uveitis Clinic at Hamad Medical Corporation from March 2007 to February 2011. All patients had detailed ocular, medical examination, and uveitis work up. RESULTS: The study included 310 patients. Anterior uveitis was noted in 53.2% of cases (165/310), followed by panuveitis 16...
August 19, 2016: Ocular Immunology and Inflammation
Miraj Ahmed, Anupam Mishra, Kamal Kumar Sawlani, Veerendra Verma, Rajiv Garg, Hitendra Prakash Singh, Sunil Kumar
The Global tuberculosis control is challenged with a growing resistance to antitubercular treatment (ATT) culminating in resistant (MDR/XDR) strains; an important factor being premature withdrawal of streptomycin owing to its morbidity particularly nephrotoxicity and cochleotoxicity as guidelines for their prevention exist. An attempt is made here to address the least recognized and most debilitating vestibular toxic effects of streptomycin and defining a vestibular-protocol for its early detection and progression...
September 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
Mirinae Kim, Jae-Yon Won, Seung Yong Choi, Ji Hyeon Ju, Young-Hoon Park
PURPOSE: To assess the long-term efficacy of the most widely used anti-tumor necrosis factor alpha (TNFα) agents for treatment of HLA-B27-positive ankylosing spondylitis (AS)-related uveitis. DESIGN: Retrospective cohort study. METHODS: The medical records of 143 patients with HLA-B27-positive AS who visited Seoul St. Mary's Hospital and were taking an anti-TNFα agent for at least 1 year were studied. Subjects were divided into 3 groups according to anti-TNFα treatment: Group 1 (infliximab, 66), Group 2 (adalimumab, 45), and Group 3 (etanercept, 32)...
October 2016: American Journal of Ophthalmology
Theodora Tsirouki, Anna Dastiridou, Chrysanthos Symeonidis, Ourania Tounakaki, Irini Brazitikou, Christos Kalogeropoulos, Sofia Androudi
PURPOSE: Uveitis is a common, sight-threatening inflammatory ocular disease and includes multiple heterogeneous clinical entities. The prevalence of various types of uveitis depends upon multiple factors, such as age, sex, race, geographic distribution, environmental influence, genetics, and social habits. Epidemiologic research of uveitis is necessary to understand the etiology and immunopathogenesis of this group of diseases. The present study attempts to concentrate on the most recent information on the epidemiology of uveitis and compare it with previous knowledge...
July 28, 2016: Ocular Immunology and Inflammation
Salil Mehta
PURPOSE: To report the clinical, investigational and PET/CT scan findings of patients with presumed ocular tuberculosis and suggest a hypotheses for the pathogenesis. METHODS: Retrospective case review. Included were 10 males and 17 females with an age range: 23-71 years. RESULTS: Clinical findings include granulomatous or non-granulomatous anterior uveitis, intermediate uveitis, panuveitis, vasculitis, and multifocal serpiginous-like choroidopathy...
July 20, 2016: Ocular Immunology and Inflammation
Parthopratim Dutta Majumder, Jyotirmay Biswas, Nishat Bansal, Avirupa Ghose, Hitesh Sharma
PURPOSE: To retrospectively analyze clinical features, laboratory investigations, treatment and visual outcomes in patients with tubercular subretinal abscess. METHODS: A total of 12 eyes of 12 patients receiving a diagnosis of subretinal abscess, between 2004 and 2014, were included for this retrospective study. RESULTS: The mean age of the presentation was 29.75 ± 16.72 years (range: 14-62 years) and seven (58.3%) were male. The most common anterior segment presentation was anterior uveitis (75%)...
July 20, 2016: Ocular Immunology and Inflammation
Marta Gómez-Mariscal, Andrea Oleñik, Pablo Arriba-Palomero, Mónica García-Cosio, Francisco J Muñoz-Negrete
PURPOSE: To report an uncommon case of Kikuchi-Fujimoto disease-associated-uveitis. METHODS: A 31-year-old Caucasian woman with cervical lymphadenitis and Kikuchi-Fujimoto disease recently confirmed by biopsy, complained about unilateral blurry vision. Differential diagnoses, including non-Hodgkin lymphoma, tuberculosis, sarcoidosis, Behçet disease, rheumatoid arthritis, and juvenile idiopathic arthritis was performed. We undertook a review of other similar cases found in the literature...
July 15, 2016: Ocular Immunology and Inflammation
Naseh Mohammadi, Fariba Ghassemi, Esfandiar Shojaei, Pardis Moradnejad
PURPOSE: To describe a case of bilateral presumed tuberculous choroiditis which resolved promptly with a short course of antituberculous therapy. CASE REPORT: A 44-year-old lady presented with bilateral visual loss of 8 months'duration. Considering the presence of pan-uveitis, severe macular edema, multifocal leakage on fluorescein angiography, positive tuberculin skin test, and after excluding other diseases, she underwent anti-tuberculous therapy (ATT) for disseminated choroiditis due to presumed ocular tuberculosis...
April 2016: Journal of Ophthalmic & Vision Research
Michaela Edmond, Alex Yuan, Brent A Bell, Amit Sharma, Rose M DiCicco, Lauren Tucker, James Bena, Yuankai K Tao, Sunil K Srivastava
PURPOSE: To determine the feasibility and accuracy of spectral-domain optical coherence tomography (SD-OCT) based grading of anterior chamber cell, using aqueous sampling as a standard, in a rabbit model of anterior uveitis. METHODS: Adult Dutch-belted rabbits were preimmunized with M. tuberculosis (Tb) H37RA antigen, 1 week prior to induction of anterior uveitis with an intracameral injection of Tb antigen. The anterior chamber was imaged with SD-OCT, followed by a slit lamp examination...
July 1, 2016: Investigative Ophthalmology & Visual Science
Marcus Ang, Daniel V Vasconcelos-Santos, Kusum Sharma, Massimo Accorinti, Aman Sharma, Amod Gupta, Narsing A Rao, Soon-Phaik Chee
Ocular tuberculosis remains a presumptive clinical diagnosis, as the gold standard tests for diagnosing ocular tuberculosis are often not useful: Mycobacterium tuberculosis cultures require weeks to process on Lowenstein-Jenson media and have low yield from ocular samples; while acid-fast bacilli smears or polymerase chain reaction detection of M. tuberculosis DNA have low sensitivities. Thus, diagnosis is often based on suggestive clinical signs, which are supported by positive investigations: tuberculin skin test or interferon-gamma release assays; chest X-ray findings suggestive of pulmonary tuberculosis, and/or evidence of associated systemic tuberculosis infections in the absence of other underlying disease...
July 5, 2016: Ocular Immunology and Inflammation
Ana Filipa Miranda, João Cardoso, Nadine Marques, Sandra Barros, Paula Telles, Nuno Campos
Ocular tuberculosis (TB) is considered to be rare, although its incidence has varied widely over time and in different populations. Latent TB is diagnosed when a person is infected with Mycobacterium tuberculosis but does not have active TB. During the last decade, interferon-gamma release assay tests have been developed that allow identification of patients with latent TB infection with better specificity than the tuberculin skin test and can differentiate between infection and prior vaccination. Although rare, tuberculous scleritis should be considered in the differential diagnosis of posterior scleritis...
April 2016: Arquivos Brasileiros de Oftalmologia
Rajeev Reddy Pappuru, Vivek Pravin Dave
We report an unusual presentation of ocular tuberculosis with subretinal abscess with associated posterior scleritis. This is a first-of-its-kind report of such an association. A 26-year-old female presented to us with complaints of redness, pain, and decreased vision in her left eye since 1 week. On examination, the vision in her right eye was 6/6 and in the left eye was 1/60. Detailed ocular evaluation revealed exudative retinal detachment, subretinal abscess, and disk edema. Ocular and systemic investigations were consistent with presumed tubercular etiology and posterior scleritis...
May 18, 2016: International Ophthalmology
K Walscheid, C Tappeiner, A Heiligenhaus
Sarcoidosis is an inflammatory multi-organ disease of unknown pathogenesis, characterised by non-necrotising granulomata. Sarcoidosis predominantly manifests in the lung, but any other organ may be affected. Ocular involvement is present in about 25 to 50 % of patients. The most common ocular manifestation is uveitis, especially of the anterior eye segment. If ocular sarcoidosis is suspected, interdisciplinary assessment of the patient is mandatory, including laboratory tests, chest X-ray, assessment by a specialist in internal medicine and, ideally, histological evidence of granuloma formation in a tissue specimen...
May 2016: Klinische Monatsblätter Für Augenheilkunde
M-H Errera, A Pratas, P Goldschmidt, N Sedira, J-A Sahel, J Benesty
The syndrome of recurrent vitreous hemorrhages in young men was described for the first time by Henry Eales in 1880. The association with a clinical manifestation of ocular inflammation was reported 5years later. Eales disease affects young adults who present with ischemic retinal vasculitis, with the peripheral retina most commonly affected. Most cases have been reported in South Asia. Although the etiology of this abnormality is unknown, it may be related to an immune sensitivity to Mycobacterium tuberculosis antigens...
May 2016: Journal Français D'ophtalmologie
Jayashree S Shah, Niharika Shetty, Sharath Kumar D Shah, Neelesh Kumar S Shah
Tuberculosis is very common disease in India. It is one of the most common causes of Granulomatous Uveitis in our Country even today. So the strongest suspicion in our mind when we are treating a case of Uveitis, should be TB. We reviewed all the cases of clinically suspected ocular tuberculosis attending the Ophthalmology OPD of Sri Siddhartha Medical College between December 2012 and December 2014 who were refractory to routine uveitis management and later on responded to anti-Tubercular treatment. History of TB contact, Ocular manifestation, Demographic Profile of the patients, Diagnostic test, Treatment regime were looked into...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
Sirawat Srichatrapimuk, Duangkamon Wattanatranon, Somnuek Sungkanuparph
Tuberculosis (TB) is a serious infectious disease that spreads globally. The ocular manifestations of TB are uncommon and diverse. TB panophthalmitis has been rarely reported. Here, we described a 38-year-old Thai man presenting with panophthalmitis of the right eye. Further investigation showed that he had concurrent TB lymphadenitis and central nervous system (CNS) tuberculoma, as well as HIV infection, with a CD4 cell count of 153 cells/mm(3). Despite the initial response to antituberculous agents, the disease had subsequently progressed and enucleation was required...
2016: Case Reports in Infectious Diseases
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