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Ocular Tuberculosis

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https://www.readbyqxmd.com/read/29779770/normalised-quantitative-polymerase-chain-reaction-for-diagnosis-of-tuberculosis-associated-uveitis
#1
Manas Ranjan Barik, Soveeta Rath, Rohit Modi, Rajkishori Rana, Mamatha M Reddy, Soumyava Basu
Polymerase chain reaction (PCR)-based diagnosis of tuberculosis-associated uveitis (TBU) in TB-endemic countries is challenging due to likelihood of latent mycobacterial infection in both immune and non-immune cells. In this study, we investigated normalised quantitative PCR (nqPCR) in ocular fluids (aqueous/vitreous) for diagnosis of TBU in a TB-endemic population. Mycobacterial copy numbers (mpb64 gene) were normalised to host genome copy numbers (RNAse P RNA component H1 [RPPH1] gene) in TBU (n = 16) and control (n = 13) samples (discovery cohort)...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29746443/presumed-tuberculous-multifocal-retinitis-in-patients-under-treatment-with-biologic-agents
#2
Tiago E Arantes, Luiz H Lima, Gláucio L Bressanin, Cláudia D Marques, Ângela B Duarte, Cristina Muccioli
PURPOSE: To report unique retinal fundus lesions and treatment outcomes of intraocular tuberculosis in patients under anti-tumor necrosis factor treatment. METHODS: Retrospective review of two patients with laboratorial evidence of tuberculosis who had bilateral ocular signs and symptoms not attributable to other diseases. Multimodal imaging was analyzed at the time of presentation and after the treatment initiation. The study patients underwent standard treatment for tuberculosis...
May 4, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29697588/the-collaborative-ocular-tuberculosis-study-cots-1-a-multinational-review-of-251-patients-with-tubercular-retinal-vasculitis
#3
Dinesh V Gunasekeran, Rupesh Agrawal, Aniruddha Agarwal, Ester Carreño, Dhananjay Raje, Kanika Aggarwal, Onn M Kon, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta
PURPOSE: Tubercular retinal vasculitis (TRV) is a heterogeneous disease that can be difficult to manage because of nonspecific presentation and limitations of confirmatory tests for tuberculosis. This is a big data analysis on phenotypes and treatment outcomes for TRV. METHODS: Multicentre retrospective study of patients with TRV between January 2004 and December 2014 and a minimum follow-up of 1 year. RESULTS: Two hundred and fifty-one patients with TRV with a mean age of 38...
April 24, 2018: Retina
https://www.readbyqxmd.com/read/29679545/the-impact-of-ocular-tuberculosis-on-vision-after-two-months-of-intensive-therapy
#4
Suzana Batista Vereza de Oliveira, Ângelo Ferreira Passos, David Jamil Hadad, Lorena Zbyszynski, Pedro Sousa de Almeida Júnior, Luiz Guilherme Schmidt Castellani, Reynaldo Dietze, Moisés Palaci
Tuberculosis (TB) is an infectious disease of global importance with major economic and social burden accounting for 25% of all avoidable deaths in developing countries. Extrapulmonary involvement may occur either in association with clinically apparent pulmonary tuberculosis or in isolation. This cross-sectional descriptive study aimed to evaluate the impact of ocular tuberculosis in visual acuity at baseline and after two months of intensive anti-tuberculous therapy. A sample of 133 pulmonary TB patients, seven disseminated TB, and three pleural TB patients was evaluated...
April 18, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29656829/-uveitis-treated-with-biotherapy-and-or-dmard-analysis-from-the-french-pharmacovigilance-study-base
#5
L Cabane, S Baillif, B Baldin, V Breuil, L Euller-Ziegler, N Tieulié
PURPOSE: To report the characteristics of uveitis cases occurring while on biologic therapy or disease-modifying antirheumatic drugs (DMARDs) reported to the French national pharmacovigilance database. METHODS: All the uveitis cases occurring in patients with chronic rheumatologic diseases, chronic inflammatory intestinal diseases or connective tissue diseases, while treated with DMARDs and/or biologic therapies between 2000 and 2015 and reported to the French National Pharmacovigilance Database were collected...
April 13, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29625462/retinal-pigment-epithelial-cells-control-early-mycobacterium-tuberculosis-infection-via-interferon-signaling
#6
Rina La Distia Nora, Kimberley V Walburg, P Martin van Hagen, Sigrid M A Swagemakers, Peter J van der Spek, Edwin Quinten, Mirjam van Velthoven, Tom H M Ottenhoff, Willem A Dik, Mariëlle C Haks
Purpose: Mycobacterium tuberculosis (Mtb) bacilli have been found in retinal pigment epithelial (RPE) cells from uveitis patients without signs of systemic tuberculosis (TB) infection. RPE cells are important for ocular immune privilege and uveitis development. Methods: To address a potential role for Mtb-infected RPE cells in the development of uveitis, we delineated the response to Mtb infection in human RPE cells and primary human macrophages, the main target cell of Mtb...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29622703/immune-stromal-keratitis-a-rare-ocular-presentation-of-tuberculosis
#7
Deepali Singhal, Prafulla Kumar Maharana, Namrata Sharma, Jeewan S Titiyal
An 11-year-old female patient presented with diminution of vision in both the eyes for the last 4 days. She had redness, watering and photophobia for the past 11 days. Slit lamp examination revealed multiple disc-shaped corneal stromal infiltrates with an overlying epithelial defect and hypopyon in both the eyes. A provisional diagnosis of infective keratitis was made. The patient was started on empirical antimicrobial therapy. However, no improvement was noted over the next 72 hours. Microbiological examination of the corneal scraping from both the eyes was negative...
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29604973/other-central-nervous-system-infections-cytomegalovirus-mycobacterium-tuberculosis-and-treponema-pallidum
#8
Christina M Marra
Human immunodeficiency virus (HIV)-infected individuals are particularly susceptible to several central nervous system infections: human cytomegalovirus, which may cause encephalitis, ventriculitis, polyradiculitis, or polyradiculomyelitis; Mycobacterium tuberculosis, which can cause meningitis or space-occupying lesions; and Treponema pallidum subspecies pallidum (T. pallidum), which affects the meninges, cerebrospinal fluid, cranial nerves, and vasculature in early neurosyphilis, and additionally the brain and spinal cord parenchyma in late neurosyphilis...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29604284/effect-of-anti-tuberculous-therapy-on-uveitis-associated-with-latent-tuberculosis
#9
Oren Tomkins-Netzer, B C S Leong, X Z Zhang, S Lightman, P J McCluskey, Oren Tomkins-Netzer, B C S Leong, A J Lee, X Z Zhang, K Leahy, S Zagora, C Younan, A T Fung, P V Nguyen, S Lertsumitkul, S Lightman, P J McCluskey
PURPOSE: To describe the clinical features of patients with uveitis associated with latent tuberculosis (TB) and examine the effect of anti-TB treatment (ATT) on uveitis outcome. DESIGN: Retrospective cohort study METHODS: 199 eyes of 129 patients diagnosed with uveitis associated with latent TB were evaluated for recurrence of disease following treatment. Eighty nine of the patients (69%) received ATT and information was gathered retrospectively regarding clinical outcome, vision and treatment...
March 28, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29584775/a-zebrafish-model-for-ocular-tuberculosis
#10
Kevin Takaki, Lalita Ramakrishnan, Soumyava Basu
Ocular tuberculosis (TB) commonly causes severe inflammation and vision loss in TB-endemic countries. The mechanism by which tuberculous infection becomes established in the eye is poorly understood. We have developed the zebrafish larva infected with Mycobacterium marinum as a model to study the early pathogenesis of ocular TB. We find that hematogenous bacterial seeding of the eye occurs despite a functional blood retinal barrier. Prototypical early granulomas form in response to bacteria in the eye. These granulomas involve the retinal vasculature and retinal pigment epithelium-choroid complex which are characteristic locations for human ocular TB...
2018: PloS One
https://www.readbyqxmd.com/read/29582812/changing-uveitis-patterns-in-south-india-comparison-between-two-decades
#11
Jyotirmay Biswas, Ranju Kharel Sitaula, Priyansha Multani
Purpose: Changing pattern of uveitis in a subset of a population is an important ocular health indicator. Methods: A comparative study was done between uveitis patients of 2013 and 1995 using two proportions Z-test. Results: In 2013, 352 new uveitis cases were examined. Males 56%, females 44%; unilateral 30.4%; bilateral in 69.6%. A specific diagnosis achieved in 66.2%. Anterior uveitis was seen in 35.22%, intermediate uveitis in 30.11%, posterior uveitis in 25%, and panuveitis in 9...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29580651/-ocular-tuberculosis-a-case-series
#12
M Koubaa, F Smaoui, S Gargouri, H Ben Ayed, K Rekik, I Abid, I Maaloul, J Feki, C Marrakchi, M Ben Jemaa
OBJECTIVES: Ocular tuberculosis is a rare form of extra pulmonary tuberculosis. It represents 1-2% of all clinical forms. The aim of this work was to focus on diagnostic and therapeutic characteristics of ocular tuberculosis. METHODS: We report a case series of 14 patients with ocular tuberculosis seen in an infectious diseases department between 2006 and 2015. The diagnosis was retained on clinical data and a positive tuberculin skin test or interferon-gamma release assay...
March 23, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29543549/role-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-the-diagnosis-of-intraocular-inflammation-in-india-our-experience
#13
Bhagya Sudheer, Manisha Agarwal, Deepa Sharma, Ravi Mehta, Kalpana Babu
PURPOSE: To report our experience of using Endobronchial ultrasound-guided transbronchial lymph node aspiration (EBUS-TBNA) in assessing the etiology in uveitis from two tertiary eye-care centers in India. MATERIALS & METHODS: Retrospective interventional case series. RESULTS: A total of 99 patients of uveitis who underwent EBUS-TBNA were included in the study. Mycobacterium tuberculosis (MTb) was detected on culture in 5 cases, 3 cases by polymerase chain reaction and caseating granulomas in 25 cases...
March 15, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29450389/unilateral-eales-disease-a-case-report
#14
Andreea Nicolcescu, Carmen Mocanu, Loredana Dinu, Andrei Olaru, Mara Ionete, Dima Alin Stefanescu
Introduction. Eales disease is an idiopathic peripheral vascular occlusive disease characterized by inflammation, ischemia, and retinal neovascularization and is hallmarked by recurrent vitreous hemorrhages and vision loss. Case report. We present a case of a 48-year-old female with recurrent floaters and decreased vision in her right eye. The onset of symptoms was in 2007 when a diagnose of retinal vasculitis was made. She had no accompanying systemic signs and symptoms and no history of ocular trauma or previous tuberculosis infection...
April 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29450388/rare-case-of-ocular-tuberculosis-in-a-diabetic-patient-diagnostic-and-therapeutic-dilemmas
#15
Anca Pantalon, Emanuela Găman, Iustina-Silvia Crețu-Silivestru, Ciprian Danielescu
We present the case of a patient who was diagnosed by chance with macular hypopyon during a conventional interdisciplinary examination. The clinical context and the association of a systemic disease, such as uncontrolled type 1 diabetes, rendered further investigations in this patient. Due to his immunocompromised status, etiology such as ocular fungi, lymphomas, tuberculosis was taken into account. Thorough complex investigations oriented the diagnosis towards ocular tuberculosis involvement.
April 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29420114/role-of-ct-chest-and-cytology-in-differentiating-tuberculosis-from-presumed-sarcoidosis-in-uveitis
#16
Reema Bansal, Amod Gupta, Ritesh Agarwal, Mohit Dogra, Garvit Bhutani, Vishali Gupta, M R Dogra, Deeksha Katoch, Ashutosh Nath Aggarwal, Aman Sharma, Raje Nijhawan, Ritambara Nada, Uma Nahar Saikia, Pranab Dey, Digambar Behera
PURPOSE: To report the role of CT chest and cytology in suspected tubercular and sarcoid uveitis. METHODS: This is a retrospective, interventional case series of 376 uveitis patients with suspected ocular tuberculosis (TB)/sarcoidosis seen between January 2010 and April 2015 at the Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh. All underwent CT chest, and had following inclusion criteria: (1) Presence of active granulomatous anterior/intermediate/posterior uveitis or panuveitis; (2) a documented tuberculin skin test/QuantiFERON-TB Gold test; (3) all other causes of infectious/non-infectious uveitis ruled out...
February 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29380185/intravitreal-dexamethasone-implant-as-an-option-for-anti-inflammatory-therapy-of-tuberculosis-uveitis
#17
Murat Hasanreisoglu, Gokcen Gulpinar Ikiz, Zeynep Aktas, Sengul Ozdek
INTRODUCTION: Tuberculosis-associated uveitis remains a diagnostic and therapeutic challenge. After diagnosis of tuberculosis and initiation of anti-tuberculosis therapy for tuberculosis uveitis, the clinical responses are favorable. However, at 4-6 weeks of the therapy, there commonly occurs paradoxical deterioration due to an increase in inflammation which is often accompanied by cystoid macular edema. Thus, adjuvant administration of anti-inflammatory regimen should be considered. For this purpose, systemic and periocular steroids, systemic and intravitreal immunosuppressive agents have been tested...
January 29, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29356903/tubercular-retinal-vasculitis-mimicking-frosted-branch-angiitis-a-case-report
#18
Manisha Agarwal, Ankita Shrivastav, Abdul Waris
BACKGROUND: Tubercular vasculitis is an important manifestation of ocular tuberculosis and this report highlights the mimicking nature of the disease with frosted branch angiitis. RESULTS: A patient presented with a severe form of retinal vasculitis in both eyes and a branch retinal vein occlusion in the left eye. He had a positive tuberculin skin test (TST) and a raised erythrocyte sedimentation rate (ESR) and serum angiotensin-converting enzyme (ACE) levels. Radiological investigations revealed a sub-pleural nodule and mediastinal lymph nodes, which on histopathological evaluation confirmed a granulomatous etiology...
January 22, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29322275/outcome-of-polymerase-chain-reaction-pcr-analysis-in-100-suspected-cases-of-infectious-uveitis
#19
Ranju Kharel Sitaula, M K Janani, H N Madhavan, Jyotirmay Biswas
BACKGROUND: Polymerase chain reaction (PCR) analysis is an important tool in the diagnosis of infectious uveitis. A retrospective, interventional study of PCR analysis of ocular fluid in suspected infectious uveitis cases between January 2014 to July 2016 was done. Nested, real-time and broad range PCR was performed for detection of the genome of Mycobacterium tuberculosis, herpes virus family, Chikungunya virus, Toxoplasma gondii, fungus, eubacterium and propionibacterium acne. RESULTS: Total of 100 cases included, mean age was 39...
January 10, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29261089/the-collaborative-ocular-tuberculosis-study-cots-1-report-3-polymerase-chain-reaction-in-the-diagnosis-and-management-of-tubercular-uveitis-global-trends
#20
Aniruddha Agarwal, Rupesh Agrawal, Dinesh Visva Gunasekaran, Dhananjay Raje, Bhaskar Gupta, Kanika Aggarwal, Somasheila L Murthy, Mark Westcott, Soon Phaik Chee, Peter Mccluskey, Ho Su Ling, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef Khairallah, Nicholas Jones, Ilknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Ester Carreño, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A Goldstein, Carl P Herbort, Talin Barisani-Asenbauer, Julio J González-López, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Sarakshi Mahajan, Simona Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanya Abraham, Ruchi Vala, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, Emmett Cunningham, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta
PURPOSE: To analyze the role of polymerase chain reaction (PCR) of ocular fluids in management of tubercular (TB) anterior, intermediate, posterior, and panuveitis. METHODS: In Collaborative Ocular Tuberculosis Study (COTS)-1 (25 centers, n = 962), patients with TB-related uveitis were included. 59 patients undergoing PCR of intraocular fluids (18 females; 53 Asian Indians) were included. RESULTS: 59 (6.13%) of COTS-1 underwent PCR analysis...
December 20, 2017: Ocular Immunology and Inflammation
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