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non-small cell lung cancer

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https://www.readbyqxmd.com/read/29222669/the-preoperative-hba1c-level-is-an-independent-prognostic-factor-for-the-postoperative-survival-after-resection-of-non-small-cell-lung-cancer-in-elderly-patients
#1
Makoto Motoishi, Satoru Sawai, Tetsuo Hori, Naoki Yamashita
PURPOSE: The aim of this study was to investigate the influence of a history of diabetes mellitus (DM) and the glycated hemoglobin (HbA1c) level on the survival in patients who underwent complete resection for non-small cell lung cancer (NSCLC). METHODS: Of the patients who underwent complete resection for NSCLC between 2007 and 2015, 468 were classified into DM (who were currently taking medication for DM) and no DM groups as well as into high HbA1c (≥ 6.5) and normal HbA1c (< 6...
December 8, 2017: Surgery Today
https://www.readbyqxmd.com/read/29221983/medication-related-osteonecrosis-of-the-jaws-associated-with-targeted-therapy-as-monotherapy-and-in-combination-with-antiresorptives-a-report-of-7-cases-from-the-copenhagen-cohort
#2
Hoda Abel Mahedi Mohamed, Charlotte Emilie Nor Nielsen, Morten Schiodt
OBJECTIVE: The aim of this study was to report cases of medication-related osteonecrosis of the jaws (MRONJ) associated with targeted therapy (TT) with or without concomitant antiresorptive treatment, among the Copenhagen ONJ cohort, which includes all consecutive cases of MRONJ seen in Copenhagen. STUDY DESIGN: We retrospectively studied the treatment of 204 consecutive patients with MRONJ, seen between January 2010 and May 2016, to identify those associated with TT...
November 6, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29221762/continuous-infusion-of-cilengitide-plus-chemoradiotherapy-for-patients-with-stage-iii-non-small-cell-lung-cancer-a-phase-i-study
#3
Carole Massabeau, Jonathan Khalifa, Thomas Filleron, Anouchka Modesto, Laurence Bigay-Gamé, Gavin Plat, Lawrence Dierickx, Richard Aziza, Isabelle Rouquette, Carlos Gomez-Roca, Muriel Mounier, Jean-Pierre Delord, Christine Toulas, Pascale Olivier, Etienne Chatelut, Julien Mazières, Elizabeth Cohen-Jonathan Moyal
INTRODUCTION: Because of our previous preclinical results, we conducted a phase I study associating the specific αvβ3/αvβ5 integrin inhibitor cilengitide, given as a continuous infusion, with exclusive chemoradiotherapy for patients with stage III non-small-cell lung cancer. PATIENTS AND METHODS: A standard 3+3 dose escalation design was used. Cilengitide was given as a continuous infusion (dose levels of 12, 18, 27, and 40 mg/h), starting 2 weeks before and continuing for the whole course of chemoradiotherapy (66 Gy combined with platinum/vinorelbine), and then at a dose of 2000 mg twice weekly in association with chemotherapy...
November 21, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29221754/up-regulation-of-ypel1-and-ypel5-and-down-regulation-of-itga2-in-erlotinib-treated-egfr-mutant-non-small-cell-lung-cancer-a-bioinformatic-analysis
#4
Xiaoli Wu
PURPOSE: This study aimed to identify genes with significant alteration following treatment of epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) with tyrosine kinase inhibitors (TKIs). METHODS: We downloaded microarray data of GSE67051 from the Gene Expression Omnibus (GEO) database. Genes with differential expression were identified in two groups: erlotinib-treated versus DMSO-treated PC9 cells and erlotinib-treated versus DMSO-treated HCC827 cells...
December 5, 2017: Gene
https://www.readbyqxmd.com/read/29221745/upfront-surgery-as-first-line-therapy-in-selected-patients-with-stage-iiia-non-small-cell-lung-cancer
#5
Difan Zheng, Ting Ye, Hong Hu, Yawei Zhang, Yihua Sun, Jiaqing Xiang, Haiquan Chen
OBJECTIVE: Surgery plays an important role in the multidisciplinary treatment strategy for patients with stage IIIA non-small cell lung cancer (NSCLC). Besides induction therapy, patients could benefit from surgery followed by adjuvant chemotherapy and radiotherapy. This study analyzed a subset of patients with pIIIA NSCLC who underwent upfront surgery as first-line therapy. METHODS: Selected patients with pIIIA NSCLC who received upfront surgery were retrospectively analyzed...
November 3, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29221718/correlation-between-dual-energy-spectral-ct-imaging-parameters-and-pathological-grades-of-non-small-cell-lung-cancer
#6
L-Y Lin, Y Zhang, S-T Suo, F Zhang, J-J Cheng, H-W Wu
AIM: To investigate the correlation between pathological grades of non-small cell lung cancers (NSCLCs) and quantitative parameters generated in dual-energy spectral computed tomography (CT). MATERIALS AND METHODS: Fifty-three patients with NSCLCs who underwent preoperative dual-energy spectral CT imaging and surgical resection were evaluated retrospectively. These patients were divided into a low-grade group and a high-grade group based on their histopathological differentiation...
December 5, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29221648/benefit-of-using-motion-compensated-reconstructions-for-reducing-inter-observer-and-intra-observer-contouring-variation-for-organs-at-risk-in-lung-cancer-patients
#7
A McWilliam, L Lee, M Harris, H Sheikh, L Pemberton, C Faivre-Finn, M van Herk
BACKGROUND AND PURPOSE: In lung cancer patients, accuracy in contouring is hampered by image artefacts introduced by respiratory motion. With the widespread introduction of 4DCT there is additional uncertainty caused by the use of different reconstruction techniques which will influence contour definition. This work aims to assess both inter- and intra-observer contour variation on average and motion compensated (mid-position) reconstructions. MATERIAL AND METHODS: Eight early stage non-small cell lung cancer patients that received 4DCT were selected and these scans were reconstructed as average and motion compensated datasets...
December 5, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29221369/controversy-and-perspective-in-the-management-of-marginally-operable-stage-iiia-non-small-cell-lung-cancer-response-to-editorial-by-charlotte-billiet-and-dirk-de-ruysscher-and-editorial-by-dr-wanpu-yan-and-dr-david-r-jones
#8
COMMENT
https://www.readbyqxmd.com/read/29221323/management-of-non-small-cell-lung-cancer-with-egfr-mutation-the-role-of-radiotherapy-in-the-era-of-tyrosine-kinase-inhibitor-therapy-opportunities-and-challenges
#9
REVIEW
Bing Xia, Shirong Zhang, Shenglin Ma
In recent years, the treatment of advanced non-small cell lung cancer (NSCLC) was greatly promoted by the discovery of oncogenic drivers and the development of targeted therapies specific for these drivers. Somatic mutations in epidermal growth factor receptor (EGFR) are the most common type in patients with NSCLC. Small-molecule tyrosine kinase inhibitor (TKI) targeting EGFR produced relatively high response rate and long duration with acceptable toxicity profile. Also, the life expectancy in patients with active EGFR mutation has been significantly prolonged than the past...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221308/how-to-manage-tumor-located-between-upper-division-and-lingular-segment-s3-s4-segmentectomy-and-s3b-s4-segmentectomy
#10
Shin-Ichi Yamashita, Yasuhiro Yoshida, Daisuke Hamatake, Takeshi Shiraishi, Katsunobu Kawahara, Akinori Iwasaki
Segmentectomy is one of the treatment of choice for small-sized non-small cell lung cancer (NSCLC). Although simple segmentectomy is feasible even if under thoracoscopy, complicated segmentectomy which contains more than two segmental plane divisions is difficult especially thoracoscopic surgery. We here present the case of totally thoracoscopic segmentectomy between upper division and lingular segment. In the first case, the 64-year-old female patient admitted for further examination and treatment of left lung ground glass nodule...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221304/microinvasive-segmentectomy-in-a-sculpting-manner-a-case-of-vats-left-s1-2-segmentectomy
#11
Liang Xue, Yunfeng Yuan
A ground-glass opacity (GGO) lesion was discovered in a 64-year-old female 1 year ago. One month before administration, a follow-up CT showed the lesion in the apical segment of left upper lobe had increased from 8 to 11 mm in diameter. The lesion was diagnosed to be cT1aN0M0 non-small cell lung cancer (NSCLC) and a 3-port video-assisted thoracic surgery (VATS) anatomic segmentectomy was performed. Intraoperative frozen sections revealed a microinvasive adenocarcinoma. Systematic lymph node dissection was then carried out...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221287/anti-cancer-activity-of-dose-fractioned-mpe-bevacizumab-regimen-is-paralleled-by-immune-modulation-in-advanced-squamous-nslc-patients
#12
Pierpaolo Pastina, Valerio Nardone, Stefania Croci, Giuseppe Battaglia, Francesca Vanni, Cristiana Bellan, Marcella Barbarino, Veronica Ricci, Susan Costantini, Francesca Capone, Cirino Botta, Mayra Rachele Zarone, Gabriella Misso, Mariarosaria Boccellino, Michele Caraglia, Antonio Giordano, Piero Paladini, Pierfrancesco Tassone, Pierosandro Tagliaferri, Maria Grazia Cusi, Luigi Pirtoli, Pierpaolo Correale
Background: Results from the BEVA2007 trial, suggest that the metronomic chemotherapy regimen with dose-fractioned cisplatin and oral etoposide (mPE) +/- bevacizumab, a monoclonal antibody to the vascular endothelial growth factor (VEGF), shows anti-angiogenic and immunological effects and is a safe and active treatment for metastatic non-small cell lung cancer (mNSCLC) patients. We carried out a retrospective analysis aimed to evaluate the antitumor effects of this treatment in a subset of patients with squamous histology...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221282/induction-chemoradiotherapy-using-docetaxel-and-cisplatin-with-definitive-dose-radiation-followed-by-surgery-for-locally-advanced-non-small-cell-lung-cancer
#13
Hidejiro Torigoe, Junichi Soh, Shuta Tomida, Kei Namba, Hiroki Sato, Kuniaki Katsui, Katsuyuki Hotta, Kazuhiko Shien, Hiromasa Yamamoto, Masaomi Yamane, Susumu Kanazawa, Katsuyuki Kiura, Shinichiro Miyoshi, Shinichi Toyooka
Background: Induction chemoradiotherapy (CRT) followed by surgery is a therapeutic option for locally advanced non-small cell lung cancer (LA-NSCLC). Typically, around 40-50 Gy of radiation is applied as the induction-dose; however, a definitive-dose (DD) of radiation (60 Gy or higher) is occasionally applied to increase local control. We investigated the impact of induction CRT with DD radiation in LA-NSCLC patients treated with a single regimen of docetaxel and cisplatin. Methods: We reviewed 110 patients with LA-NSCLC who underwent induction CRT followed by surgery using a single regimen (docetaxel and cisplatin) between January 1999 and December 2014 at our hospital...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221277/worse-survival-after-curative-resection-in-patients-with-pathological-stage-i-non-small-cell-lung-cancer-adjoining-pulmonary-cavity-formation
#14
Hiroyuki Kimura, Hisashi Saji, Tomoyuki Miyazawa, Hiroki Sakai, Masataka Tsuda, Yoichi Wakiyama, Hideki Marushima, Koji Kojima, Haruhiko Nakamura
Background: A few investigators have suggested an association between lung cancer and pulmonary cavity. However, this clinical association and its carcinogenic correlations are not well recognized. This study aimed to clarify the clinical features and to demonstrate the associated survival outcomes after curative surgery in patients with early non-small cell lung cancer (NSCLC) adjoining pulmonary cavity formation. Methods: We retrospectively reviewed 275 patients with pathological stage I NSCLC by re-evaluating their chest computed tomography images...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221264/continuation-of-gefitinib-plus-chemotherapy-prolongs-progression-free-survival-in-advanced-non-small-cell-lung-cancer-patients-who-get-acquired-resistance-to-gefitinib-without-t790m-mutations
#15
Ting Ding, Fei Zhou, Xiaoxia Chen, Shijia Zhang, Yinan Liu, Hui Sun, Shengxiang Ren, Xuefei Li, Chao Zhao, Heyong Wang, Caicun Zhou
Background: Aimed to identify the benefit population from continuation of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), this study investigated the efficacy of continuation of EGFR-TKIs plus chemotherapy beyond the response evaluation criteria in solid tumors-progressive disease (RECIST-PD) according to different progression modes and T790M mutational status. Methods: From November 2009 to July 2015, 630 patients with advanced non-small cell lung cancer (NSCLC) receiving gefitinib as initial EGFR-TKI treatment were screened in Shanghai Pulmonary Hospital...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221254/recent-studies-move-closer-to-answering-questions-about-sequential-therapy-for-anaplastic-lymphoma-kinase-rearranged-non-small-cell-lung-cancer
#16
EDITORIAL
Tetsu Kobayashi, Hajime Fujimoto, Corina D'Alessandro-Gabazza, Esteban C Gabazza, Osamu Hataji
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221239/inflammatory-status-and-prognosis-of-locally-advanced-non-small-cell-lung-cancer
#17
EDITORIAL
José María Galvan-Roman, José Curbelo, Javier Aspa
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221236/checkpoint-inhibitors-in-metastatic-epidermal-growth-factor-receptor-mutated-non-small-cell-lung-cancer-patients-where-we-treating-the-wrong-cancer
#18
EDITORIAL
Paul Zarogoulidis, Vasilis Papadopoulos, Elena Maragouli, George Papatsibas, Haidong Huang
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221230/neoadjuvant-strategy-for-stage-iiia-n2-non-small-cell-lung-cancer-chemoradiation-or-chemotherapy-alone
#19
EDITORIAL
Dongrong Situ, Yongbin Lin
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221225/mediastinal-lymph-node-dissection-in-surgical-treatment-for-early-stage-non-small-cell-lung-cancer-lobe-specific-or-systematic
#20
EDITORIAL
Hiroyuki Adachi, Takamitsu Maehara, Haruhiko Nakayama, Munetaka Masuda
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
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