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Cost-effectiveness analysis

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https://www.readbyqxmd.com/read/28231679/-use-the-markov-decision-tree-model-to-optimize-vaccination-strategies-of-hepatitis-e-among-women-aged-15-to-49
#1
Z M Chen, S B Ji, X L Shi, Y Y Zhao, X F Zhang, H Jin
Objective: To evaluate the cost-utility of different hepatitis E vaccination strategies in women aged 15 to 49. Methods: The Markov-decision tree model was constructed to evaluate the cost-utility of three hepatitis E virus vaccination strategies. Parameters of the models were estimated on the basis of published studies and experience of experts. Both methods on sensitivity and threshold analysis were used to evaluate the uncertainties of the model. Results: Compared with non-vaccination group, strategy on post-screening vaccination with rate as 100%, could save 0...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231261/a-natural-user-interface-to-integrate-citizen-science-and-physical-exercise
#2
Eduardo Palermo, Jeffrey Laut, Oded Nov, Paolo Cappa, Maurizio Porfiri
Citizen science enables volunteers to contribute to scientific projects, where massive data collection and analysis are often required. Volunteers participate in citizen science activities online from their homes or in the field and are motivated by both intrinsic and extrinsic factors. Here, we investigated the possibility of integrating citizen science tasks within physical exercises envisaged as part of a potential rehabilitation therapy session. The citizen science activity entailed environmental mapping of a polluted body of water using a miniature instrumented boat, which was remotely controlled by the participants through their physical gesture tracked by a low-cost markerless motion capture system...
2017: PloS One
https://www.readbyqxmd.com/read/28231042/cost-effectiveness-analysis-of-four-simulated-colorectal-cancer-screening-interventions-north-carolina
#3
Kristen Hassmiller Lich, David A Cornejo, Maria E Mayorga, Michael Pignone, Florence K L Tangka, Lisa C Richardson, Tzy-Mey Kuo, Anne-Marie Meyer, Ingrid J Hall, Judith Lee Smith, Todd A Durham, Steven A Chall, Trisha M Crutchfield, Stephanie B Wheeler
INTRODUCTION: Colorectal cancer (CRC) screening rates are suboptimal, particularly among the uninsured and the under-insured and among rural and African American populations. Little guidance is available for state-level decision makers to use to prioritize investment in evidence-based interventions to improve their population's health. The objective of this study was to demonstrate use of a simulation model that incorporates synthetic census data and claims-based statistical models to project screening behavior in North Carolina...
February 23, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28230458/progression-to-type-2-diabetes-and-its-effect-on-health-care-costs-in-low-income-and-insured-patients-with-prediabetes-a-retrospective-study-using-medicaid-claims-data
#4
Jun Wu, Eileen Ward, Tiffaney Threatt, Z Kevin Lu
BACKGROUND: Prediabetes is a high-risk factor for progression to diabetes. Without lifestyle changes, such as weight loss and moderate physical activity, 15%-30% of people with prediabetes are projected to develop type 2 diabetes within 5 years. Progression to diabetes increases the financial burden significantly for patients and health care systems. Populations with low socioeconomic status are associated with a higher risk of diabetes. However, knowledge is limited about the effect of transition to diabetes on future costs incurred in low-income populations...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28230230/bronchoscopic-lung-volume-reduction-procedures-for-chronic-obstructive-pulmonary-disease
#5
REVIEW
Joseph Em van Agteren, Khin Hnin, Dion Grosser, Kristin V Carson, Brian J Smith
BACKGROUND: In the recent years, a variety of bronchoscopic lung volume reduction (BLVR) procedures have emerged that may provide a treatment option to participants suffering from moderate to severe chronic obstructive pulmonary disease (COPD). OBJECTIVES: To assess the effects of BLVR on the short- and long-term health outcomes in participants with moderate to severe COPD and determine the effectiveness and cost-effectiveness of each individual technique. SEARCH METHODS: Studies were identified from the Cochrane Airways Group Specialised Register (CAGR) and by handsearching of respiratory journals and meeting abstracts...
February 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28230045/the-single-chest-tube-versus-double-chest-tube-application-after-pulmonary-lobectomy-a-systematic-review-and-meta-analysis
#6
Xuefei Zhang, Desheng Lv, Mo Li, Ge Sun, Changhong Liu
OBJECTIVE: Draining of the chest cavity with two chest tubes after pulmonary lobectomy is a common practice. The objective of this study was to evaluate whether using two tubes after a pulmonary lobectomy is more effective than using a single tube. PATIENTS AND METHODS: We performed a meta-analysis of five randomized studies that compared the single chest tube with double chest tube application after pulmonary lobectomy. The primary end-point was amount of drainage and duration of chest tube drainage...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28229377/important-treatment-outcomes-for-patients-with-psoriatic-arthritis-a-multisite-qualitative-study
#7
Emma Dures, Sarah Hewlett, Jane Lord, Clive Bowen, Neil McHugh, William Tillett
BACKGROUND: Psoriatic arthritis (PsA) is a variable and complex inflammatory condition. Symptoms can compromise physical function, reduce quality of life, and accrue significant health costs. Commonly used patient-reported outcomes largely reflect the professionals' perspective, however it is not known whether they capture what is important to patients. OBJECTIVE: The aim of our study was to identify treatment outcomes important to patients with PsA. METHODS: Eight focus groups that were audio recorded, transcribed, anonymised and analysed using inductive thematic analysis were conducted at five hospital sites...
February 22, 2017: Patient
https://www.readbyqxmd.com/read/28229209/cost-effective-management-of-pelvic-fracture-urethral-injuries
#8
Niels V Johnsen, David F Penson, W Stuart Reynolds, Douglas F Milam, Roger R Dmochowski, Melissa R Kaufman
PURPOSE: To compare the cost-effectiveness of various treatment strategies in the management of pelvic fracture urethral injuries using decision analysis. METHODS: Five strategies were modeled from the time of injury to resolution of obstructed voiding or progression to urethroplasty. Management consisted of immediate suprapubic tube (SPT) placement and delayed urethroplasty; primary endoscopic realignment (PER) followed by urethroplasty in failed patients; or PER followed by 1-3 direct vision internal urethrotomies (DVIU), followed by urethroplasty...
February 22, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28229161/high-levels-of-latent-antithrombin-in-plasma-from-patients-with-antithrombin-deficiency
#9
María de la Morena-Barrio, Edna Sandoval, Pilar Llamas, Ewa Wypasek, Mara Toderici, José Navarro-Fernández, Agustín Rodríguez-Alen, Nuria Revilla, Raquel López-Gálvez, Antonia Miñano, José Padilla, Belén de la Morena-Barrio, Jorge Cuesta, Javier Corral, Vincente Vincente
Antithrombin is an anticoagulant serpin that efficiently inhibits multiple procoagulant proteases. The cost for the structural flexibility required for this function is the vulnerability to mutations that impact its folding pathway. Most conformational mutations identified in serpins cause polymerisation. Only three mutations in SERPINC1 affecting two residues have been found to favour transformation to the latent conformation of antithrombin, another hyperstable non-anticoagulant form with strong antiangiogenic activity that constitutes 3 % of plasma antithrombin in healthy subjects...
February 23, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28228966/objective-image-analysis-of-real-time-three-dimensional-intraoperative-ultrasound-for-intrinsic-brain-tumour-surgery
#10
Sophie J Camp, Vasileios Apostolopoulos, Vasileios Raptopoulos, Amrish Mehta, Kevin O'Neill, Mohammed Awad, Babar Vaqas, David Peterson, Federico Roncaroli, Dipankar Nandi
BACKGROUND: There is growing evidence that maximal surgical resection of primary intrinsic brain tumours is beneficial, both by improving progression free and overall survival and also by facilitating postoperative chemotherapy and radiotherapy. Hence, there has been an increase in the popularity of real-time intraoperative imaging in brain tumour surgery. The complex theatre arrangements, prohibitive cost and prolonged theatre time of intraoperative MRI have restricted its application...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28228368/a-web-based-physical-activity-intervention-for-spanish-speaking-latinas-a-costs-and-cost-effectiveness-analysis
#11
Britta Larsen, Bess Marcus, Dori Pekmezi, Sheri Hartman, Todd Gilmer
BACKGROUND: Latinas report particularly low levels of physical activity and suffer from greater rates of lifestyle-related conditions such as obesity and diabetes. Interventions are needed that can increase physical activity in this growing population in a large-scale, cost-effective manner. Web-based interventions may have potential given the increase in Internet use among Latinas and the scalability of Web-based programs. OBJECTIVE: To examine the costs and cost-effectiveness of a Web-based, Spanish-language physical activity intervention for Latinas compared to a wellness contact control...
February 22, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28228182/cost-effectiveness-of-computerized-cognitive-behavioural-therapy-for-the-treatment-of-depression-in-primary-care-findings-from-the-randomised-evaluation-of-the-effectiveness-and-acceptability-of-computerised-therapy-reeact-trial
#12
A Duarte, S Walker, E Littlewood, S Brabyn, C Hewitt, S Gilbody, S Palmer
BACKGROUND: Computerized cognitive-behavioural therapy (cCBT) forms a core component of stepped psychological care for depression. Existing evidence for cCBT has been informed by developer-led trials. This is the first study based on a large independent pragmatic trial to assess the cost-effectiveness of cCBT as an adjunct to usual general practitioner (GP) care compared with usual GP care alone and to establish the differential cost-effectiveness of a free-to-use cCBT programme (MoodGYM) in comparison with a commercial programme (Beating the Blues) in primary care...
February 23, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28228141/factors-associated-with-contraceptive-use-in-tigray-north-ethiopia
#13
Araya Abrha Medhanyie, Alem Desta, Mussie Alemayehu, Tesfay Gebrehiwot, Tesfu Alemu Abraha, Atakelti Abrha, Hagos Godefay
BACKGROUND: Family planning interventions are cost-effective and have several cross-cutting benefits. Despite these benefits of family planning, progress in ensuring universal access to family planning to women in developing countries has been slow. In light of this; this study investigated the prevalence and factors associated with contraceptive use in Tigray Region, Northern Ethiopia. METHODS: A community-based cross-sectional study was conducted among 1966 women of reproductive age group (15-49) in 13 districts (3 urban and 10 rural) from May-June 2015...
February 23, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28227933/classification-of-severity-of-mitral-regurgitation-patients-using-multifractal-analysis
#14
Rijil Thomas, Ling Lieng Hsi, Soh Cheong Boon, Erry Gunawan, Rijil Thomas, Ling Lieng Hsi, Soh Cheong Boon, Erry Gunawan, Soh Cheong Boon, Erry Gunawan, Ling Lieng Hsi
Owing to its efficiency and cost effectiveness, auscultation using a stethoscope is the primary diagnosis method preferred by most medical examiners for cardiovascular disease. Phonocardiography (PCG) is the next level of auscultation and an effective analysis technique in cardiology. This paper presents a method to quantify Mitral Regurgitation (MR) using PCG. MR is one of the most common cardiovascular diseases associated with a defect in mitral valve. We analyzed the multifractal nature of heart sounds with murmur followed by classification and clustering using Hurst exponents...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227693/using-bioimpedance-spectroscopy-parameters-as-real-time-feedback-during-tdcs
#15
Isar Nejadgholi, Herschel Caytak, Miodrag Bolic, Isar Nejadgholi, Herschel Caytak, Miodrag Bolic, Isar Nejadgholi, Miodrag Bolic, Herschel Caytak
An exploratory analysis is carried out to investigate the feasibility of using BioImpedance Spectroscopy (BIS) parameters, measured on scalp, as real-time feedback during Transcranial Direct Current Stimulation (tDCS). TDCS is shown to be a potential treatment for neurological disorders. However, this technique is not considered as a reliable clinical treatment, due to the lack of a measurable indicator of treatment efficacy. Although the voltage that is applied on the head is very simple to measure during a tDCS session, changes of voltage are difficult to interpret in terms of variables that affect clinical outcome...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227433/microprinted-tumor-spheroids-enable-anti-cancer-drug-screening
#16
Pradip S Thakuri, Stephanie L Ham, Hossein Tavana, Pradip S Thakuri, Stephanie L Ham, Hossein Tavana, Stephanie L Ham, Hossein Tavana
Spheroids present a biologically relevant model of avascular tumors and a unique tool for discovery of anti-cancer drugs. Despite being used in research laboratories for several decades, spheroids are not routinely used for drug discovery primarily due to the difficulty of mass-producing uniformly-sized spheroids and intense labor involved in handling, drug treatment, and analyzing them. We overcome this barrier using a novel technology to robotically microprint spheroids in standard 384-well plates. An aqueous drop containing cancer cells is dispensed into a bath of a second, immiscible aqueous phase...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227258/electrocardiographic-waveforms-fitness-check-device-technique-for-sudden-cardiac-death-risk-screening
#17
O J Escalona, M Mendoza, O J Escalona, M Mendoza, O J Escalona, M Mendoza
A novel cardiac health device technique development for reliable, non-invasive and cost-effective heart screening in preventive cardiovascular healthcare is presented. In particular, identification of apparently healthy individuals involved in sports activities (particularly in the young, age <; 35 years) who may be at-risk of sudden-cardiac-death (SCD) is mainly focused here. Nevertheless, the same device technique may be prospectively extended for detecting cardiovascular abnormalities in children and adolescents with type1-diabetes, and also in detecting patients with Brugada syndrome...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225651/robotic-surgery-a-solution-in-search-of-a-problem-a-bayesian-analysis-of-343-robotic-procedures-performed-by-a-single-surgical-team
#18
Simona Manciu, Mihnea Dragomir, Fabiana Curea, Catalin Vasilescu
BACKGROUND: Despite the obvious technical advantages, the value of robotic surgery is highly debated and its cost-effectiveness has been questioned. The aim of this article is to provide an evaluation of the outcomes of robotic surgery in comparison to conventional laparoscopy. METHODS: A decision analysis based on the Bayes' theorem and the decision tree was used. The robotic approach was compared with the laparoscopic approach for each of the pathologies discussed in this study...
February 22, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28225639/cost-effectiveness-comparison-of-imaging-guided-prostate-biopsy-techniques-systematic-transrectal-ultrasound-direct-in-bore-mri-and-image-fusion
#19
Wulphert Venderink, Tim M Govers, Maarten de Rooij, Jurgen J Fütterer, J P Michiel Sedelaar
OBJECTIVE: Three commonly used prostate biopsy approaches are systematic transrectal ultrasound guided, direct in-bore MRI guided, and image fusion guided. The aim of this study was to calculate which strategy is most cost-effective. MATERIALS AND METHODS: A decision tree and Markov model were developed to compare cost-effectiveness. Literature review and expert opinion were used as input. A strategy was deemed cost-effective if the costs of gaining one quality-adjusted life year (incremental cost-effectiveness ratio) did not exceed the willingness-to-pay threshold of €80,000 (≈$85,000 in January 2017)...
February 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28225444/third-line-salvage-chemotherapy-for-recurrent-carcinoma-of-the-cervix-is-associated-with-minimal-response-rate-and-high-toxicity
#20
Dustin B Manders, Siobhan M Kehoe, David S Miller, Jayanthi S Lea, Debra L Richardson
BACKGROUND: Metastatic and recurrent cervical cancer is rarely a curable disease. Systemic chemotherapy is typically recommended for treatment based on clinical trials in the first-line or second-line setting. Rare patients who progress through 2 salvage regimens will have the performance status, medical ability, and desire to continue cytotoxic therapy. For these patients, there are no data to provide effective counseling regarding expected response rates (RRs) and toxicities. We sought to review our experience with this patient population...
February 20, 2017: American Journal of Clinical Oncology
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