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Gall bladder cancer

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https://www.readbyqxmd.com/read/27770143/-1-h-nuclear-magnetic-resonance-nmr-based-serum-metabolomics-of-human-gallbladder-inflammation
#1
Raj Kumar Sharma, Kumudesh Mishra, Alvina Farooqui, Anu Behari, Vinay Kumar Kapoor, Neeraj Sinha
OBJECTIVE AND DESIGN: We present in this article (1)H nuclear magnetic resonance (NMR)-based metabolic approach to screen the serum metabolic alterations in human gallbladder inflammation with chronic cholecystitis (CC). MATERIAL/METHODS: Total of 71 human serum samples was divided into two groups, (n = 41, CC) and (n = 30 control). (1)H NMR metabolic profiling was carried out for investigation of metabolic alterations. Multivariate statistical analysis was applied for pattern recognition and identification of metabolites playing crucial role in gallbladder inflammation...
October 21, 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/27529044/an-extremely-rare-case-of-advanced-metastatic-small-cell-neuroendocrine-carcinoma-of-sinonasal-tract
#2
Yu Yu Thar, Poras Patel, Tiangui Huang, Elizabeth Guevara
Small cell neuroendocrine carcinoma (SNEC) is a rare form of malignancy. It mainly presents as bronchogenic neoplasm, and the extrapulmonary form accounts for only 0.1% to 0.4% of all cancers. These extrapulmonary tumors have been described most frequently in the urinary bladder, prostate, esophagus, stomach, colon and rectum, gall bladder, head and neck, cervix, and skin. Primary SNEC of the sinonasal tract is extremely rare with only less than 100 cases reported in the literature. Because of extreme rarity and aggressiveness of the tumor, the management for this entity varies considerably mandating multimodality approach...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27509990/risk-factors-for-gallbladder-cancer-in-nepal-a-case-control-study
#3
D Tamrakar, Is Paudel, S Adhikary, B Rauniyar, Pk Pokharel
BACKGROUND: Gall bladder cancer (GBC) is highly fatal disease with poor prognosis, with a 5 year survival rate of <10%. It is relatively rare cancer worldwide; however it is the sixth cancer and second most common gastrointestinal tract cancer in Nepalese women. The study focused on associations of certain demographic, lifestyle, dietary, and reproductive factors with gall bladder cancer. MATERIALS AND METHODS: We conducted a hospitalbased matched case control study on newly diagnosed cases of primary GBC at BP Koirala Institute of Health Sciences and BP Koirala Memorial Cancer Hospital...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27490345/liver-resection-for-non-colorectal-non-neuroendocrine-metastases
#4
Nicholas A R Clarke, Harsh A Kanhere, Markus I Trochsler, Guy J Maddern
OBJECTIVE: Liver resections for non-colorectal non-neuroendocrine liver metastases (NCNELM) are gaining popularity. This study examines the outcomes of liver resections in patients with NCNELM in an Australian hospital. METHOD: A database search identified 21 attempted liver resections on 20 patients (12 men, eight women, mean age: 63.1) from 1998 to 2013. A retrospective analysis considered patient demographics and primary malignancy details. Complication rates were compared to those for colorectal metastases at the same institution...
August 3, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27475647/quantification-of-circulating-free-dna-as-a-diagnostic-marker-in-gall-bladder-cancer
#5
Swati Kumari, Shikha Tewari, Nuzhat Husain, Akash Agarwal, Anshuman Pandey, Ashish Singhal, Mohtashim Lohani
Gall bladder Carcinoma (GBC) is the fifth most common cancer of the digestive tract and frequently diagnosed in late stage of disease. Estimation of circulating free DNA (cfDNA) in serum has been applied as a "liquid biopsy" in several deep seated malignancies. Its value in diagnosis of gall bladder carcinoma has not been studied. The present study was designed to assess the role of cfDNA in the diagnosis of GBC and correlate levels with the TNM stage. Serum was collected from 34 patients with GBC and 39 age and sex matched controls including 22 cholecystitis and 17 healthy individuals...
July 30, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27457720/the-combination-effects-of-body-acupuncture-and-auricular-acupressure-compared-to-sham-acupuncture-for-body-weight-control-study-protocol-for-a-randomized-controlled-trial
#6
Linda L D Zhong, Wai Kun, Tsz Fung Lam, Shi Ping Zhang, Jun Jun Yang, Tat Chi Ziea, Bacon Ng, Zhao Xiang Bian
BACKGROUND: Obesity is an increasingly prevalent chronic condition that is associated with serious morbidity and mortality. Excess body weight is a risk factor contributing to diseases such as hypertension, heart disease, hypercholesterolaemia, diabetes mellitus, cerebrovascular disease, gall bladder disease, and some types of cancer. Almost all the Western anti-obesity drugs have adverse effects or body weight is regained upon cessation of therapy. Recent studies have found that acupuncture had a similar efficacy as the Western anti-obesity drugs with fewer reported adverse effects...
July 25, 2016: Trials
https://www.readbyqxmd.com/read/27381065/carcinoma-of-gall-bladder-with-distant-metastasis-to-breast-parenchyma-report-of-a-case-and-review-of-literature
#7
Damodara Kumaran, Manikandan Anamalai, Umesh Velu, Aruna Nambirajan, Pramod Kumar Julka
BACKGROUND: Gall bladder carcinoma is one of the most common cancers in India. Gall bladder cancer with metastasis to the breast is very rare. Herein we intend to report a case of carcinoma gall bladder with breast metastasis and a short review of the literature. METHODS: This report describes an interesting and unusual case of gall bladder carcinoma presenting with breast metastasis. CASE REPORT: A 38-year lady presented with complaints of right abdominal pain...
December 2016: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/27362364/silibinin-a-potential-old-drug-for-cancer-therapy
#8
Xing-Xing Zhu, Ya-Hui Ding, Yi Wu, Lin-Yan Qian, Hai Zou, Qiang He
INTRODUCTION: Silibinin is mixture of flavonolignans extracted from milk thistle and often has been used in the treatment of acute and chronic liver disorders caused by toxins, drug, alcohol and hepatitis and gall bladder disorders for its antioxidant and hepatoprotective properties. AREAS COVERED: However, increasing evidence suggest that silibinin is not solely limited in the treatment of these diseases. Further research suggests that silymarin may function diversely and may serve as a novel therapy for cancer therapy, such as lung cancer, prostatic cancer, colon cancer, breast cancer, bladder cancer and hepatocellular carcinoma by regulating cancer cells growth, proliferation, apoptosis, angiogenesis and many other mechanism...
July 18, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27338241/high-expression-of-karyopherin-%C3%AE-2-and-stathmin-1-is-associated-with-proliferation-potency-and-transformation-in-the-bile-duct-and-gall-bladder-epithelia-in-the-cases-of-pancreaticobiliary-maljunction
#9
Fumiyoshi Saito, Kenichiro Araki, Takehiko Yokobori, Norihiro Ishii, Mariko Tsukagoshi, Akira Watanabe, Norio Kubo, Bolag Altan, Ken Shirabe, Hiroyuki Kuwano
BACKGROUNDS AND OBJECTIVES: Pancreaticobiliary maljunction (PBM) may be associated with an increased frequency of gall bladder cancer with no bile duct dilation. Karyopherin-α2 (KPNA2) and stathmin 1 (STMN1) were reported to play important roles in carcinogenesis and cancer progression. METHODS: Fifteen patients with PBM who underwent surgical resection between 1999 and 2014 were included in this study. Using immunohistochemistry, we investigated the expression of p53, Ki-67, KPNA2, and STMN1 in normal biliary tract epithelium, hyperplastic epithelium, and cholangiocarcinoma (CC) tissues...
September 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27321059/epidemiological-evidence-on-environmental-tobacco-smoke-and-cancers-other-than-lung-or-breast
#10
Peter N Lee, Alison J Thornton, Janette S Hamling
We reviewed 87 epidemiological studies relating environmental tobacco smoke (ETS) exposure to risk of cancer other than lung or breast in never smoking adults. This updates a 2002 review which also considered breast cancer. Meta-analysis showed no significant relationship with ETS for nasopharynx cancer, head and neck cancer, various digestive cancers (stomach, rectum, colorectal, liver, pancreas), or cancers of endometrium, ovary, bladder and brain. For some cancers (including oesophagus, colon, gall bladder and lymphoma) more limited data did not suggest a relationship...
October 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27312033/report-on-demographics-of-gall-bladder-cancer-in-delaware-and-retrospective-review-of-treatment-strategies-for-gallbladder-cancer-in-a-large-community-cancer-center
#11
REVIEW
Muhammad Baig, Michael Guarino, Nicholas Petrelli
BACKGROUND: GBC is frequently found incidentally on pathologic review of the removed gallbladder. NCCN guidelines have treatment recommendations based on specific stage of gallbladder cancer (GBC). However, there is limited information on the experience of community cancer centers in treating GBC based on these guidelines. OBJECTIVE: To utilize the Delaware cancer registry to describe patients with GBC in Delaware, and to conduct a review of the treatment strategies and outcomes of GBC at a large community cancer center...
June 2016: Surgical Oncology
https://www.readbyqxmd.com/read/27305883/t2-gallbladder-cancer-aggressive-therapy-is-warranted
#12
Mohd Raashid Sheikh, Houssam Osman, Susannah Cheek, Shenee Hunter, Dhiresh Rohan Jeyarajah
Treatment of gall bladder cancer (GBC) has traditionally been viewed with pessimism and lymph node positivity has been associated with worse prognosis. The aim of this study is to analyze the role of radical cholecystectomy in T2 tumors. All patients who underwent surgery for GBC between September 2005 and June 2014 were identified retrospectively. Data collected included clinical presentation, operative findings, and histopathological data. Twenty-five patients had incidental GBC diagnosis after cholecystectomy...
June 2016: American Surgeon
https://www.readbyqxmd.com/read/27303130/carcinoid-tumour-of-caecum-an-unusual-palpable-mass-in-the-right-iliac-fossa
#13
Mohit M Agrawal, Nandkishor S Sude
Carcinoid tumour represents 0.8-1.5 % of malignant digestive tumours. Gastrointestinal (GI) carcinoids account for 95 % of all the carcinoids, and caecal carcinoids account for 5 % of all the carcinoids. These tumours are frequent in women (2-4:1) as reported by Spallitta and Termine (Minerva Chir 55:77-87, 2002). In order of frequency, they may occur in the appendix (35 %), ileum (28 %), rectum (13 %) and bronchi. Incidence is less than 1 % in the pancreas, gall bladder, liver, larynx, testes and ovaries...
April 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/27221939/randomized-control-screening-trials-to-lower-gall-bladder-cancer-mortality-in-high-risk-populations
#14
Manigreeva Krishnatreya, Amal Chandra Kataki
Gall bladder cancer is generally fatal. The high morbidity and mortality due to gall bladder cancer exerts a significant impact on efforts towards cancer control in high risk populations of the World and a rationale program for control of gall bladder cancer mortality has remained as an unmet need in these populations. Currently there are no effective strategies for controlling gall bladder cancer mortality. This mini review is to highlight the need and feasibility for secondary prevention of gall bladder cancer by screening in high risk populations...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27221908/radiological-downstaging-with-neoadjuvant-therapy-in-unresectable-gall-bladder-cancer-cases
#15
Sushma Agrawal, Lalit Mohan, Chandan Mourya, Zafar Neyaz, Rajan Saxena
BACKGROUND: Gall bladder cancer (GBC) usually presents as unresectable or metastatic disease. We conducted a feasibility study to evaluate the effect of neoadjuvant therapy (NAT) on radiologic downstaging and resectability in unresectable GBC cases. MATERIALS AND METHODS: Patients with locally advanced disease were treated with chemoradiotherapy [CTRT] ( external radiotherapy (45Gy) along with weekly concurrent cisplatin 35mg/ m2 and 5-FU 500 mg) and those with positive paraaortic nodes were treated with neoadjuvant chemotherapy [NACT (cisplatin 25mg/m2 and gemcitabine 1gm/m2 day 1 and 8, 3 weekly for 3 cycles)...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27217672/need-for-prophylactic-cholecystectomy-in-silent-gall-stones-in-north-india
#16
REVIEW
Alok Vardhan Mathur
One of the criteria for recommending cholecystectomy for silent gall stones, is gall stones in regions with high incidence of gall bladder cancer. Both gall stones and gall bladder cancer are common in North India. All tertiary care centres in India report high rates of gall bladder cancer (GBC) incidence and poor treatment outcomes in the majority of cases due to advanced stage of presentation. Csendes of Chile has reported very high incidence of gallbladder cancer in Chile and Bolivia and advocated prophylactic cholecystectomy in asymptomatic patients...
September 2015: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27211249/second-line-palliative-chemotherapy-in-advanced-gall-bladder-cancer-cap-iri-safe-and-effective-option
#17
Anant Ramaswamy, Vikas Ostwal, Nikhil Pande, Arvind Sahu, Sunny Jandyal, Mukta Ramadwar, Nitin Shetty, Shraddha Patkar, Mahesh Goel, Sudeep Gupta
INTRODUCTION: Gall bladder cancer (GBC) has high prevalence in the Indo-Gangetic belt in India. While the first-line chemotherapy (CT1) has been established as gemcitabine-platinum doublet in advanced GBC, there is no standard recommendation or guidelines regarding feasibility of second-line therapy. METHODS: We performed a retrospective analysis of all patients who received second-line of chemotherapy (CT2) at our institution from July 2012 to December 2014. Patient records were examined for efficacy and toxicity of administered CT2, along with response rates (RR) and survival...
September 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/27209646/drug-induced-liver-injury-caused-by-iodine-131
#18
Chei Won Kim, Ji Sun Park, Se Hwan Oh, Jae-Hyung Park, Hyun-Ik Shim, Jae Woong Yoon, Jin Seok Park, Seong Bin Hong, Jun Mi Kim, Trong Binh Le, Jin Woo Lee
Iodine-131 is a radioisotope that is routinely used for the treatment of differentiated thyroid cancer after total or near-total thyroidectomy. However, there is some evidence that iodine-131 can induce liver injury . Here we report a rare case of drug-induced liver injury (DILI) caused by iodine-131 in a patient with regional lymph node metastasis after total thyroidectomy. A 47-year-old woman was admitted with elevated liver enzymes and symptoms of general weakness and nausea. Ten weeks earlier she had undergone a total thyroidectomy for papillary thyroid carcinoma and had subsequently been prescribed levothyroxine to reduce the level of thyroid-stimulating hormone...
June 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/27123469/surgically-resected-gall-bladder-is-histopathology-needed-for-all
#19
Vikash Talreja, Aun Ali, Rabel Khawaja, Kiran Rani, Sunil Sadruddin Samnani, Farah Naz Farid
Background. Laparoscopic cholecystectomy is considered to be gold standard for symptomatic gall stones. As a routine every specimen is sent for histopathological examination postoperatively. Incidentally finding gall bladder cancers in those specimens is around 0.5-1.1%. The aim of this study is to identify those preoperative and intraoperative factors in patients with incidental gall bladder cancer to reduce unnecessary work load on pathologist and cost of investigation particularly in a developing world. Methods...
2016: Surgery Research and Practice
https://www.readbyqxmd.com/read/27096770/early-results-of-liver-resection-using-laparoscopic-technique
#20
Maciej Stanek, Michał Pędziwiatr, Dorota Radkowiak, Anna Zychowicz, Piotr Budzyński, Piotr Major, Andrzej Budzyński
UNLABELLED: The aim of the study was to present early outcomes of liver resection using laparoscopic technique. MATERIAL AND METHODS: Retrospective analysis of patients who underwent liver resection using laparoscopic method was conducted. The analyzed group included 23 patients (11 women and 12 men). An average patient age was 61.3 years (37 - 83 years). Metastases of the colorectal cancer to the liver were the cause for qualification to the procedure of 15 patients, metastasis of breast cancer in 1 patient and primary liver malignancy in 5 patients...
January 1, 2016: Polski Przeglad Chirurgiczny
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