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https://www.readbyqxmd.com/read/28229895/impulse-control-disorders-and-levodopa-induced-dyskinesias-in-parkinson-s-disease-an-update
#1
REVIEW
Valerie Voon, T Celeste Napier, Michael J Frank, Veronique Sgambato-Faure, Anthony A Grace, Maria Rodriguez-Oroz, Jose Obeso, Erwan Bezard, Pierre-Olivier Fernagut
Dopaminergic medications used in the treatment of patients with Parkinson's disease are associated with motor and non-motor behavioural side-effects, such as dyskinesias and impulse control disorders also known as behavioural addictions. Levodopa-induced dyskinesias occur in up to 80% of patients with Parkinson's after a few years of chronic treatment. Impulse control disorders, including gambling disorder, binge eating disorder, compulsive sexual behaviour, and compulsive shopping occur in about 17% of patients with Parkinson's disease on dopamine agonists...
March 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28223961/a-spanish-validation-of-the-canadian-adolescent-gambling-inventory-cagi
#2
Susana Jiménez-Murcia, Roser Granero, Randy Stinchfield, Joël Tremblay, Amparo Del Pino-Gutiérrez, Laura Moragas, Lamprini G Savvidou, Fernando Fernández-Aranda, Neus Aymamí, Mónica Gómez-Peña, Salomé Tárrega, Katarina Gunnard, Virginia Martín-Romera, Trevor Steward, Gemma Mestre-Bach, José M Menchón
Aims: Large-scale epidemiological studies show a significant prevalence of gambling disorder (GD) during adolescence and emerging adulthood, and highlight the need to identify gambling-related behaviors at early ages. However, there are only a handful of screening instruments for this population and many studies measuring youth gambling problems use adult instruments that may not be developmentally appropriate. The aim of this study was to validate a Spanish version of the Canadian Adolescent Gambling Inventory (CAGI) among late adolescent and young adults and to explore its psychometric properties...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28219609/neuroscience-in-gambling-policy-and-treatment-an-interdisciplinary-perspective
#3
REVIEW
Murat Yücel, Adrian Carter, Amy R Allen, Bernard Balleine, Luke Clark, Nicki A Dowling, Sally M Gainsbury, Anna E Goudriaan, Jon Grant, Alan Hayes, David Hodgins, Ruth van Holst, Ralph Lattimore, Charles Livingstone, Valentina Lorenzetti, Dan Lubman, Carsten Murawski, Linden Parkes, Nancy Petry, Robin Room, Bruce Singh, Anna Thomas, Phil Townshend, George Youssef, Wayne Hall
Neuroscientific explanations of gambling disorder can help people make sense of their experiences and guide the development of psychosocial interventions. However, the societal perceptions and implications of these explanations are not always clear or helpful. Two workshops in 2013 and 2014 brought together multidisciplinary researchers aiming to improve the clinical and policy-related effects of neuroscience research on gambling. The workshops revealed that neuroscience can be used to improve identification of the dangers of products used in gambling...
February 14, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28214771/future-oriented-mental-time-travel-in-individuals-with-disordered-gambling
#4
Xavier Noël, Mélanie Saeremans, Charles Kornreich, Nematollah Jaafari, Arnaud D'Argembeau
This study investigated the ability of individuals with disordered gambling to imagine future events. Problem gamblers (n=35) and control participants (n=35) were asked to imagine positive and negative future events for three temporal distances (one week, one year, 5-10years). Then, a variety of phenomenological aspects of their future thoughts (e.g., sensory and contextual details, autonoetic consciousness) were rated. Compared to control subjects, problem gamblers generated fewer positive and negative events across all temporal distances, an impairment that was correlated to verbal fluency scores...
February 16, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28198636/gambling-disorder-related-illegal-acts-regression-model-of-associated-factors
#5
Mohamed Ali Gorsane, Michel Reynaud, Jean-Luc Vénisse, Cindy Legauffre, Marc Valleur, David Magalon, Mélina Fatséas, Isabelle Chéreau-Boudet, Alice Guilleux, Gaëlle Challet-Bouju, Marie Grall-Bronnec
Background and aims Gambling disorder-related illegal acts (GDRIA) are often crucial events for gamblers and/or their entourage. This study was designed to determine the predictive factors of GDRIA. Methods Participants were 372 gamblers reporting at least three DSM-IV-TR (American Psychiatric Association, 2000) criteria. They were assessed on the basis of sociodemographic characteristics, gambling-related characteristics, their personality profile, and psychiatric comorbidities. A multiple logistic regression was performed to identify the relevant predictors of GDRIA and their relative contribution to the prediction of the presence of GDRIA...
February 15, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28178678/the-awakening-of-the-cdk10-cyclin-m-protein-kinase
#6
Vincent J Guen, Carly Gamble, Jacqueline A Lees, Pierre Colas
Cyclin-dependent kinases (CDKs) play important roles in the control of fundamental cellular processes. Some of the most characterized CDKs are considered to be pertinent therapeutic targets for cancers and other diseases, and first clinical successes have recently been obtained with CDK inhibitors. Although discovered in the pre-genomic era, CDK10 attracted little attention until it was identified as a major determinant of resistance to endocrine therapy for breast cancer. In some studies, CDK10 has been shown to promote cell proliferation whereas other studies have revealed a tumor suppressor function...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28162086/adult-adhd-is-associated-with-gambling-severity-and-psychiatric-comorbidity-among-treatment-seeking-problem-gamblers
#7
Laura Brandt, Gabriele Fischer
OBJECTIVE: The aim of this study is as follows: (a) exploring retrospective childhood and adult ADHD symptomatology in treatment-seeking gamblers, (b) providing detailed characteristics of the association between pathological gambling (PG) and ADHD, and (c) identifying risk factors for a history of ADHD. METHOD: Eighty problem gamblers (20% female) were examined using a standardized interview (PG: Diagnostic and Statistical Manual of Mental Disorders [4th ed.; DSM-IV] criteria, Gambling Attitudes and Beliefs Survey; ADHD: Wender Utah Rating Scale- deutsche Kurzform, Adult ADHD Self-Report Scale; comorbidities: Mini International Neuropsychiatric Interview)...
February 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28160035/brexpiprazole-reduces-hyperactivity-impulsivity-and-risk-preference-behavior-in-mice-with-dopamine-transporter-knockdown-a-model-of-mania
#8
Morgane Milienne-Petiot, Mark A Geyer, Jørn Arnt, Jared W Young
RATIONALE: Bipolar disorder (BD) is a unique mood disorder defined by periods of depression and mania. The defining diagnosis of BD is the presence of mania/hypomania, with symptoms including hyperactivity and risk-taking. Since current treatments do not ameliorate cognitive deficits such as risky decision-making, and impulsivity that can negatively affect a patient's quality of life, better treatments are needed. OBJECTIVES: Here, we tested whether acute treatment with brexpiprazole, a serotonin-dopamine activity modulator with partial agonist activity at D2/3 and 5-HT1A receptors, would attenuate the BD mania-relevant behaviors of the dopamine transporter (DAT) knockdown mouse model of mania...
February 3, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28154956/me-myself-and-money-ii-relative-deprivation-predicts-disordered-gambling-severity-via-delay-discounting-especially-among-gamblers-who-have-a-financially-focused-self-concept
#9
Nassim Tabri, N Will Shead, Michael J A Wohl
In the current research, we examined whether the known link between relative deprivation and disordered gambling (via delay discounting; i.e., preferences for immediate smaller rewards relative to delayed larger rewards) is moderated by the extent to which gamblers have a financially focused self-concept. Specifically, we hypothesized that delay discounting would be a strong predictor of disordered gambling among those who base their self-worth on their financial success. To test this moderated-mediation model, a community sample of gamblers (N = 239) completed measures that assessed relative deprivation, delay discounting, financially focused self-concept, and disordered gambling severity...
February 2, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28150390/gray-matter-relationships-to-diagnostic-and-transdiagnostic-features-of-drug-and-behavioral-addictions
#10
Sarah W Yip, Patrick D Worhunsky, Jiansong Xu, Kristen P Morie, R Todd Constable, Robert T Malison, Kathleen M Carroll, Marc N Potenza
Alterations in neural structure have been reported in both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation in neural structure has also been associated with impulsivity, a dimensional construct implicated in addictions. This study combines categorical (diagnosis-based) and dimensional (transdiagnostic) approaches to identify neural structural alterations linked to addiction subtypes and trait impulsivity, respectively, across individuals with gambling disorder (n = 35), individuals with cocaine-use disorder (n = 37) and healthy comparison individuals (n = 37)...
February 1, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28135641/sensation-seeking-in-a-community-sample-of-french-gamblers-comparison-between-strategic-and-non-strategic-gamblers
#11
Céline Bonnaire, Catherine Bungener, Isabelle Varescon
The purpose of this research is to examine the relationship between sensation seeking and gambling disorder (GD) in a community sample of gamblers (when controlling for the effect of substance use, gender and age) and see whether sensation seeking scores depend on the gambling activity when comparing strategic and non-strategic gamblers. A total of 380 gamblers was recruited. First, pathological gamblers (PGs) (n =143) were compared to non-pathological gamblers (NPGs) (n =237). Second, strategic gamblers (n =93) were compared to non-strategic gamblers (n =110)...
January 22, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28131932/common-and-differential-brain-abnormalities-in-gambling-disorder-subtypes-based-on-risk-attitude
#12
Hideaki Takeuchi, Kosuke Tsurumi, Takuro Murao, Ariyoshi Takemura, Ryosaku Kawada, Shin-Ichi Urayama, Toshihiko Aso, Gen-Ichi Sugihara, Jun Miyata, Toshiya Murai, Hidehiko Takahashi
Studying brain abnormalities in behavioral addiction including GD enables us to exclude possible confounding effects of exposure to neurotoxic substances, which should provide important insight that can lead to a better understanding of addiction per se. There have been a few brain structural magnetic resonance imaging studies for GD, although the results have been inconsistent. On the other hand, GD was suggested to be a heterogeneous disorder in terms of risk attitude. We aimed to examine the heterogeneity of GD by combining a behavioral economics task and voxel-based morphometry...
January 22, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28126343/management-of-impulse-control-disorders-with-deep-brain-stimulation-a-double-edged-sword
#13
REVIEW
Chayut Kasemsuk, Genko Oyama, Nobutaka Hattori
Deep brain stimulation (DBS) is a surgical option for advanced Parkinson's disease. Although DBS is used to treat motor fluctuation, DBS may affect non-motor symptoms including mood disorders, cognitive dysfunction, and behavior problems. Impulse control disorders (ICDs) are abnormal behaviors with various manifestations such as pathological gambling, hypersexuality, compulsive shopping, and binge eating, which can affect the quality of life in patients with Parkinson's disease. The effect of DBS on ICD is controversial...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28126210/enhanced-risk-aversion-but-not-loss-aversion-in-unmedicated-pathological-anxiety
#14
Caroline J Charpentier, Jessica Aylward, Jonathan P Roiser, Oliver J Robinson
BACKGROUND: Anxiety disorders are associated with disruptions in both emotional processing and decision making. As a result, anxious individuals often make decisions that favor harm avoidance. However, this bias could be driven by enhanced aversion to uncertainty about the decision outcome (e.g., risk) or aversion to negative outcomes (e.g., loss). Distinguishing between these possibilities may provide a better cognitive understanding of anxiety disorders and hence inform treatment strategies...
December 16, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28118729/the-role-of-affect-driven-impulsivity-in-gambling-cognitions-a-convenience-sample-study-with-a-spanish-version-of-the-gambling-related-cognitions-scale
#15
Francesco Del Prete, Trevor Steward, Juan F Navas, Fernando Fernández-Aranda, Susana Jiménez-Murcia, Tian P S Oei, José C Perales
Background and aims Abnormal cognitions are among the most salient domain-specific features of gambling disorder. The aims of this study were: (a) to examine and validate a Spanish version of the Gambling-Related Cognitions Scale (GRCS; Raylu & Oei, 2004) and (b) to examine associations between cognitive distortion levels, impulsivity, and gambling behavior. Methods This study first recruited a convenience sample of 500 adults who had gambled during the previous year. Participants were assessed using the Spanish version of GRCS (GRCS-S) questionnaire, the UPPS-P impulsivity questionnaire, measures of gambling behavior, and potentially relevant confounders...
January 25, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28096672/a-biopsychological-review-of-gambling-disorder
#16
REVIEW
Gabriel C Quintero
The present review is an overview of previous experimental work on biopsychological aspects of gambling disorder. It includes the topics 1) gambling disorder from the neuroimaging and electroencephalography (EEG) perspective, 2) cognitive, executive functioning, and neuropsychological aspects of gambling disorder, and 3) rodent models of gambling disorder. Penalties and losses in gambling can differ in terms of brain activity. Also, specific patterns of brain activity, brain anatomical traits, EEG responses, and cognitive and executive performance can discriminate pathological gamblers from nonpathological gamblers...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28092198/attentional-bias-in-excessive-internet-gamers-experimental-investigations-using-an-addiction-stroop-and-a-visual-probe
#17
Franziska Jeromin, Nele Nyenhuis, Antonia Barke
Background and aims Internet Gaming Disorder is included in the Diagnostic and statistical manual of mental disorders (5(th) edition) as a disorder that merits further research. The diagnostic criteria are based on those for Substance Use Disorder and Gambling Disorder. Excessive gamblers and persons with Substance Use Disorder show attentional biases towards stimuli related to their addictions. We investigated whether excessive Internet gamers show a similar attentional bias, by using two established experimental paradigms...
March 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28092195/serum-bdnf-levels-in-patients-with-gambling-disorder-are-associated-with-the-severity-of-gambling-disorder-and-iowa-gambling-task-indices
#18
Sam-Wook Choi, Young-Chul Shin, Jung Yeon Mok, Dai-Jin Kim, Jung-Seok Choi, Samuel Suk-Hyun Hwang
Background and aims Gambling disorder (GD) shares many similarities with substance use disorders (SUDs) in clinical, neurobiological, and neurocognitive features, including decision-making. We evaluated the relationships among, GD, decision-making, and brain-derived neurotrophic factor (BDNF), as measured by serum BDNF levels. Methods Twenty-one male patients with GD and 21 healthy sex- and age-matched control subjects were evaluated for associations between serum BDNF levels and the Problem Gambling Severity Index (PGSI), as well as between serum BDNF levels and Iowa Gambling Task (IGT) indices...
March 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28092190/examining-personalized-feedback-interventions-for-gambling-disorders-a-systematic-review
#19
REVIEW
Loredana Marchica, Jeffrey L Derevensky
Background and aims Personalized feedback interventions (PFI) have shown success as a low-cost, scalable intervention for reducing problematic and excessive consumption of alcohol. Recently, researchers have begun to apply PFI as an intervention method for problematic gambling behaviors. A systematic review of the literature on PFI as an intervention/prevention method for gambling behaviors was performed. Methods Studies were included if they met the following criteria: the design included both a PFI group and a comparison group, and the interventions focused on gambling prevention and/or reduction...
March 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28077222/prediction-of-relapse-after-cognitive-behavioral-treatment-of-gambling-disorder-in-individuals-with-chronic-schizophrenia-a-survival-analysis
#20
Enrique Echeburúa, Montserrat Gómez, Montserrat Freixa
Gambling disorder (GD) in individuals with chronic schizophrenia is relevant because there are higher rates of GD in schizophrenic populations (10%) than in the nonschizophrenic population (1%-5%). In addition, these patients have more severe alcohol use disorder (i.e., meeting at least 6 of the DSM-5 11 criteria for diagnosis of this disorder), higher depression scores, a poor adherence to treatment, and more frequent use of outpatient mental health care. One of the main problems in GD is therapeutic failure (defined as three or more lapse episodes during treatment) or relapse (three or more lapse episodes in the follow-up period)...
January 2017: Behavior Therapy
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