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https://www.readbyqxmd.com/read/28528231/neurocognitive-dysfunction-in-problem-gamblers-with-co-occurring-antisocial-personality-disorder
#1
Austin W Blum, Eric W Leppink, Jon E Grant
OBJECTIVES: Problem gamblers with symptoms of antisocial personality disorder (ASPD) may represent a distinct problem gambling subtype, but the neurocognitive profile of individuals affected by both disorders is poorly characterized. METHOD: Non-treatment-seeking young adults (18-29years) who gambled ≥5 times in the preceding year were recruited from the general community. Problem gamblers (defined as those meeting ≥1 DSM-5 diagnostic criteria for gambling disorder) with a lifetime history of ASPD (N=26) were identified using the Mini International Neuropsychiatric Interview (MINI) and compared with controls (N=266) using questionnaire-based impulsivity scales and objective computerized neuropsychological tasks...
May 12, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28523287/modeling-risky-decision-making-in-nonhuman-animals-shared-core-features
#2
Sarah R Heilbronner
Understanding the neural mechanisms of risky decision-making is critical to developing appropriate treatments for psychiatric disorders, problem gambling, and addiction to drugs of abuse. Probing neurobiological mechanisms requires the use of nonhuman animal models (particularly rhesus macaques, rats, and mice). However, there is considerable variation across species in risk preferences. Nevertheless, there are shared core features of risky decision-making present across species. As demonstrated with a wide variety of behavioral paradigms, modulators of risk preference observed in humans are readily replicated in model species...
August 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/28521732/the-berlin-inventory-of-gambling-behavior-screening-big-s-validation-using-a-clinical-sample
#3
Martin Wejbera, Kai W Müller, Jan Becker, Manfred E Beutel
BACKGROUND: Published diagnostic questionnaires for gambling disorder in German are either based on DSM-III criteria or focus on aspects other than life time prevalence. This study was designed to assess the usability of the DSM-IV criteria based Berlin Inventory of Gambling Behavior Screening tool in a clinical sample and adapt it to DSM-5 criteria. METHODS: In a sample of 432 patients presenting for behavioral addiction assessment at the University Medical Center Mainz, we checked the screening tool's results against clinical diagnosis and compared a subsample of n=300 clinically diagnosed gambling disorder patients with a comparison group of n=132...
May 18, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28515502/ismp-adverse-drug-reactions-pregabalin-induced-stuttering-nitroglycerine-induced-bradycardia-progressing-to-asystole-minocycline-induced-dress-leading-to-liver-transplantation-and-type-1-diabetes-increased-risk-of-vertebral-fractures-in-women-receiving-thiazide
#4
Michael A Mancano
The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28511259/impulse-control-disorders-and-related-complications-of-parkinson-s-disease-therapy
#5
Alexander M Lopez, Daniel Weintraub, Daniel O Claassen
Impulsive and compulsive behaviors in Parkinson's disease (PD) patients are most often attributed to dopamine agonist therapy; dysregulation of the mesocorticolimbic system accounts for this behavioral phenotype. The clinical presentation is commonly termed impulse control disorder (ICD): Behaviors include hypersexuality, compulsive eating, shopping, pathological gambling, and compulsive hobby participation. However, not all PD individuals taking dopamine agonists develop these behavioral changes. In this review, the authors focus on the similarities between the phenotypic presentation of ICDs with that of other reward-based behavioral disorders, including binge eating disorder, pathological gambling, and substance use disorders...
April 2017: Seminars in Neurology
https://www.readbyqxmd.com/read/28490234/are-self-rated-and-behavioural-measures-of-impulsivity-in-bipolar-disorder-mainly-related-to-comorbid-substance-use-problems
#6
Isabelle E Bauer, Thomas D Meyer, Marsal Sanches, Danielle Spiker, Giovana Zunta-Soares, Jair C Soares
INTRODUCTION: Impulsivity is a multidimensional feature observed in bipolar disorder (BD) and substance use disorder (SUD). We previously found a relationship between SUD and risk taking in BD. It is still unclear whether self-rated and behavioral impulsivity measures differ between BD with and without comorbid SUD, or are specific to BD. METHODS: 93 adults with BD with comorbid SUD, 91 BD without SUD, and 93 healthy controls (HC) were administered the Barratt Impulsivity Scale (BIS), the Behavioral Inhibition/Behavioral Activation System Scale (BIS/BAS), and the Cambridge Neuropsychological Test Automated Battery...
May 11, 2017: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/28486792/gambling-disorder-an-integrative-review-of-animal-and-human-studies
#7
REVIEW
Katherine M Nautiyal, Mayumi Okuda, Rene Hen, Carlos Blanco
Gambling disorder (GD), previously called pathological gambling and classified as an impulse control disorder in DSM-III and DSM-IV, has recently been reclassified as an addictive disorder in the DSM-5. It is widely recognized as an important public health problem associated with substantial personal and social costs, high rates of psychiatric comorbidity, poor physical health, and elevated suicide rates. A number of risk factors have been identified, including some genetic polymorphisms. Animal models have been developed in order to study the underlying neural basis of GD...
April 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28475942/distinct-cognitive-performance-and-patterns-of-drug-use-among-early-and-late-onset-cocaine-users
#8
Bruna Mayara Lopes, Priscila Dib Gonçalves, Mariella Ometto, Bernardo Dos Santos, Mikael Cavallet, Tiffany Moukbel Chaim-Avancini, Mauricio Henriques Serpa, Sergio Nicastri, André Malbergier, Geraldo F Busatto, Arthur Guerra de Andrade, Paulo Jannuzzi Cunha
INTRODUCTION: Adolescence is a crucial period for neurodevelopment, but few studies have investigated the impact of early cocaine use on cognitive performance and patterns of substance use. METHODS: We evaluated 103 cocaine dependent inpatients divided in two groups: early-onset users (EOG; n=52), late-onset users (LOG; n=51), and 63 healthy controls. Neuropsychological functioning was evaluated using Digits Forward (DF) and Backward (DB), Trail Making Test (TMT), Stroop Color Word Test (SCWT), Controlled Oral Word Association Test (COWAT), Wisconsin Card Sorting Test (WCST), Rey Osterrieth Complex Figure Test (ROCFT), Frontal Assessment Battery (FAB), and Iowa Gambling Test (IGT)...
April 29, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28471014/reckless-self-destructive-behavior-and-ptsd-in-veterans-the-mediating-role-of-new-adverse-events
#9
Joanna D Lusk, Naomi Sadeh, Erika J Wolf, Mark W Miller
The addition of self-destructive and reckless behavior as a symptom of posttraumatic stress disorder (PTSD) in DSM-5 has stimulated renewed interest in understanding relationships between these behaviors and trauma-related psychopathology. This study examined the relationship between reckless and self-destructive behaviors (RSDB), intervening exposure to new adverse events, and later PTSD severity in a sample of trauma-exposed veterans. At baseline, participants were assessed for RSDB (past 5 years) and current PTSD severity (N = 222)...
May 4, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28465711/treatment-modalities-for-patients-with-gambling-disorder
#10
REVIEW
Sam-Wook Choi, Young-Chul Shin, Dai-Jin Kim, Jung-Seok Choi, Seohee Kim, Seung-Hyun Kim, HyunChul Youn
BACKGROUND: Gambling disorder (GD) is defined as persistent and recurrent problematic gambling behavior leading to clinically significant impairment or distress. The prevalence of GD has been shown to be 1.2-7.1% in the general population. GD can severely impact on personal and vocational wellbeing as well as lead to financial problems, and has been known to be difficult to treat. This review describes the available pharmacotherapy/psychosocial treatments for GD patients, and summarizes data on the effectiveness of these GD treatments...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28462585/pramipexole-modulates-interregional-connectivity-within-the-sensorimotor-network
#11
Zheng Ye, Anke Hammer, Thomas F Münte
Pramipexole is widely prescribed to treat Parkinson's disease but has been reported to cause impulse control disorders such as pathological gambling. Recent neurocomputational models suggested that D2 agonists may distort functional connections between the striatum and the motor cortex, resulting in impaired reinforcement learning and pathological gambling. To examine how D2 agonists modulate the striatal-motor connectivity, we carried out a pharmacological resting-state functional magnetic resonance imaging study with a double-blind randomized within-subject crossover design...
May 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28459730/substance-use-and-addictive-disorders-in-dsm-5-and-icd-10-and-the-draft-icd-11
#12
John B Saunders
PURPOSE OF REVIEW: The present review compares and contrasts the diagnostic entities and taxonomy of substance use and addictive disorders in the beta draft of the Eleventh Revision of the International Classification of Diseases (ICD 11), which was released in November 2016, and the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which was published in mid-2013. Recently published papers relevant to these two classification systems are examined. New initiatives in diagnosis and assessment including the addictions neuroclinical assessment are noted...
April 28, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/28457951/hiv-tat-and-dopaminergic-transmission
#13
REVIEW
Peter Gaskill, Doug Miller, Joyonna-Gamble George, Hideaki Yano, Habibeh Khoshbouei
Human Immunodeficiency Virus (HIV) is a progressive infection that targets the immune system, affecting more than 37 million people around the world. While combinatorial antiretroviral therapy (cART) has lowered mortality rates and improved quality of life in infected individuals, the prevalence of HIV associated neurocognitive disorders is increasing and HIV associated cognitive decline remains prevalent. Recent research has suggested that HIV accessory proteins may be involved in this decline, and several studies have indicated that the HIV protein transactivator of transcription (Tat) can disrupt normal neuronal and glial function...
April 27, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28456569/neural-correlates-of-cognitive-control-in-gambling-disorder-a-systematic-review-of-fmri-studies
#14
REVIEW
Lorenzo Moccia, Mauro Pettorruso, Franco De Crescenzo, Luisa De Risio, Luigi di Nuzzo, Giovanni Martinotti, Angelo Bifone, Luigi Janiri, Marco Di Nicola
Decreased cognitive control over the urge to be involved in gambling activities is a core feature of Gambling Disorder (GD). Cognitive control can be differentiated into several cognitive sub-processes pivotal in GD clinical phenomenology, such as response inhibition, conflict monitoring, decision-making, and cognitive flexibility. This article aims to systematically review fMRI studies, which investigated the neural mechanisms underlying diminished cognitive control in GD. We conducted a comprehensive literature search and collected neuropsychological and neuroimaging data investigating cognitive control in GD...
April 26, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28451473/blunted-reward-processing-in-remitted-melancholic-depression
#15
Anna Weinberg, Stewart A Shankman
Blunted reward response appears to be a trait-like marker of vulnerability for Major Depressive Disorder (MDD). As such, it should be present in remitted individuals; however, depression is a heterogeneous syndrome. Reward-related impairments may be more pronounced in individuals with melancholic depression. The present study examined neural responses to rewards in remitted melancholic depression (rMD; N = 29), remitted non-melancholic depression (rNMD; N = 56), and healthy controls (HC; N = 81). Event-related potentials to monetary gain and loss were recorded during a simple gambling paradigm...
January 2017: Clinical Psychological Science
https://www.readbyqxmd.com/read/28447289/electroencephalographic-evidence-of-abnormal-anticipatory-uncertainty-processing-in-gambling-disorder-patients
#16
Alberto Megías, Juan F Navas, Ana Perandrés-Gómez, Antonio Maldonado, Andrés Catena, José C Perales
Putting money at stake produces anticipatory uncertainty, a process that has been linked to key features of gambling. Here we examined how learning and individual differences modulate the stimulus preceding negativity (SPN, an electroencephalographic signature of perceived uncertainty of valued outcomes) in gambling disorder patients (GDPs) and healthy controls (HCs), during a non-gambling contingency learning task. Twenty-four GDPs and 26 HCs performed a causal learning task under conditions of high and medium uncertainty (HU, MU; null and positive cue-outcome contingency, respectively)...
April 26, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28447288/understanding-the-relationship-between-subjective-wellbeing-and-gambling-behavior
#17
Lisa Farrell
This paper examines the relationship between gambling behavior and subjective wellbeing. It is often asserted that populations consist of different types of gamblers: those for whom gambling is a harmless leisure activity and those (pathological/problem gamblers) for whom the activity has harmful effects. One might, therefore, assume that subjective wellbeing will be negativity associated with an individual's level of gambling addiction. Alternatively, gamblers may choose to gamble because they derive utility from participating in this activity and so the relationship between happiness and gambling might be positively correlated...
April 26, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28439243/relationships-between-behavioural-addictions-and-psychiatric-disorders-what-is-known-and-what-is-yet-to-be-learned
#18
Vladan Starcevic, Yasser Khazaal
This article provides a narrative review of the relationships between several behavioural addictions [pathological gambling, problematic Internet use (PIU), problematic online gaming, compulsive sexual behaviour disorder, compulsive buying, and exercise addiction] and psychiatric disorders. Associations between most behavioural addictions and depressive and anxiety disorders are strong and seem relatively non-specific. Strong links with substance use disorders may support the notion that some people are more prone to addictive behaviours, regardless of whether these involve substances or problematic activities...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28436719/gambling-frequency-and-symptoms-of-attention-deficit-hyperactivity-disorder-in-relation-to-problem-gambling-among-swedish-adolescents-a-population-based-study
#19
Charlotta Hellström, Philippe Wagner, Kent W Nilsson, Jerzy Leppert, Cecilia Åslund
AIM: To investigate the associations between gambling frequency, attention-deficit hyperactivity disorder (ADHD) symptoms, and problem gambling among adolescent boys and girls. One hypothesis was that adolescents with increased ADHD symptoms have a higher frequency of gambling compared to adolescents with fewer ADHD symptoms. METHOD: A population-based sample of adolescents (aged 15-18 years) completed a questionnaire on demographics, gambling habits, ADHD symptoms, and problematic gambling; 1412 adolescents (from 4440 sampled) with gambling experience were included in the final sample...
April 24, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28429468/decision-making-in-obesity-without-eating-disorders-a-systematic-review-and-meta-analysis-of-iowa-gambling-task-performances
#20
REVIEW
J-Y Rotge, C Poitou, P Fossati, J Aron-Wisnewsky, J-M Oppert
BACKGROUND: There is evidence that obesity is associated with impairments in executive functions, such as deficits in decision-making, planning or problem solving, which might interfere with weight loss in obese individuals. We performed a systematic review and meta-analysis of decision-making abilities, as measured with the Iowa gambling task (IGT), in obesity without eating disorders. METHODS: A systematic search was conducted to identify studies comparing IGT performances between groups of obese patients without eating disorders and groups of healthy control groups...
April 21, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
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