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https://www.readbyqxmd.com/read/29344579/prognostic-significance-of-cytogenetic-heterogeneity-in-patients-with-newly-diagnosed-multiple-myeloma
#1
Maximilian Merz, Anna Jauch, Thomas Hielscher, Tilmann Bochtler, Stefan Olaf Schönland, Anja Seckinger, Dirk Hose, Uta Bertsch, Kai Neben, Marc Steffen Raab, Jens Hillengass, Hans Salwender, Igor Wolfgang Blau, Hans-Walter Lindemann, Ingo G H Schmidt-Wolf, Christof Scheid, Mathias Haenel, Katja C Weisel, Hartmut Goldschmidt
We investigated subclonal cytogenetic aberrations (CA) detected by interphase fluorescence in situ hybridization (iFISH) in patients with newly diagnosed multiple myeloma (MM) enrolled in the Haemato Oncology Foundation for Adults in the Netherlands (HOVON)-65/German-Speaking MM Group (GMMG)-HD4 phase 3 trial. Patients were either treated with 3 cycles of vincristine, Adriamycin, and dexamethasone or bortezomib, Adriamycin, and dexamethasone and then thalidomide or bortezomib maintenance after tandem autologous transplantation...
January 9, 2018: Blood Advances
https://www.readbyqxmd.com/read/29344263/thalidomide-inhibits-proliferation-and-epithelial-mesenchymal-transition-by-modulating-cd133-expression-in-pancreatic-cancer-cells
#2
Congying Chen, Ge Yu, Wenqin Xiao, Miao Xing, Jianbo Ni, Rong Wan, Guoyong Hu
Pancreatic cancer is a solid malignancy with a high mortality rate, on account of the high incidence of metastasis at the time of detection. The aggressiveness of pancreatic cancer may be partly driven by cancer stem cells (CSCs), which are characterized by the ability to self-renew and recapitulate tumors in the ectopic setting. However, although a number of drugs targeting CSCs are currently under clinical investigation, few effective drugs have been developed. The present study demonstrated that thalidomide inhibited cell proliferation and metastasis in pancreatic cancer cell lines through the inhibition of epithelial mesenchymal transition...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344159/p38-predicts-depression-and-poor-outcome-in-esophageal-cancer
#3
Yao Cheng, Zhe Qiao, Chengxue Dang, Bin Zhou, Shaomin Li, Wei Zhang, Jiantao Jiang, Yongchun Song, Jin Zhang, Dongmei Diao
p38 mitogen-activated protein kinase (MAPK) signaling has been implicated in the cancer development and progression. However, the precise mechanism of this association remains unknown. The aim of the present study was to evaluate the association between p38 and cancer progression, including investigations into the effects on cell proliferation, resistance to thalidomide, indoleamine 2,3-dioxygenase (IDO) expression and prognosis in patients with esophageal cancer. The present retrospective study included patients with stage I-III esophageal cancer...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29340127/restarting-thalidomide-dexamethasone-regimen-in-a-post-abortive-female-with-multiple-myeloma-effective-clinical-response-possible
#4
Suhailur Rehman, S H Arif, Amit Kumar, A Q Khan
Nowadays, the prevalence of Multiple Myeloma (MM) seems to have been increasing among young females. Here, we report that thalidomide is contraindicated in pregnant women diagnosed with MM and those desirous of subsequent pregnancy. In this case report, we compared the clinical response of Thalidomide-Dexamethasone therapy in a post-abortive woman with persistently elevated β-hCG levels due to retained products of conception, undergoing hysterectomy later. This case report underlines the clinical significance of age, the effect of Thalidomide-Dexamethasone therapy even after initial discontinuation and the response to high β-hCG levels...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29335406/thalidomide-plus-prednisone-with-or-without-danazol-therapy-in-myelofibrosis-a-retrospective-analysis-of-incidence-and-durability-of-anemia-response
#5
Xueping Luo, Zefeng Xu, Bing Li, Tiejun Qin, Peihong Zhang, Hongli Zhang, Liwei Fang, Lijuan Pan, Naibo Hu, Shiqiang Qu, Yue Zhang, Gang Huang, Robert Peter Gale, Zhijian Xiao
Low-dose thalidomide and prednisone alone or combined are effective therapies in some persons with primary myelofibrosis (PMF) and anemia with or with RBC transfusion dependence. Danazol is also effective in some persons with PMF and anemia. Responses to these drugs are typically incomplete and not sustained. It is unclear whether adding danazol to thalidomide and prednisone would improve efficacy. We retrospectively compared the outcomes of 88 subjects with PMF and anemia receiving thalidomide and prednisone without (n = 46) or with danazol (n = 42)...
January 15, 2018: Blood Cancer Journal
https://www.readbyqxmd.com/read/29327635/an-open-label-clinical-trial-of-thalidomide-in-nsaids-refractory-ankylosing-spondylitis
#6
Minhaj Rahim Choudhury, M Masudul Hassan, M Ekramul Kabir, M Golam Rabbani, Syed Atiqul Haq, Md Kasedur Rahman
No abstract text is available yet for this article.
January 12, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29307240/the-role-of-the-placenta-in-drug-transport-and-fetal-drug-exposure
#7
Gideon Koren, Asher Ornoy
It was assumed for decades that the human placenta serves as a barrier, protecting the fetus from exposure to xenobiotics circulating in the mother. The thalidomide disaster completely reversed this concept. The study of the human placenta is therefore critical to understanding the mechanisms by which xenobiotics reach the fetus and exert their effects. Areas covered: This review describes mechanisms by which drugs interact with the human placenta, and experimental methods to study these interactions in humans...
January 16, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29296944/recent-trends-in-multiple-myeloma-incidence-and-survival-by-age-race-and-ethnicity-in-the-united-states
#8
Luciano J Costa, Ilene K Brill, James Omel, Kelly Godby, Shaji K Kumar, Elizabeth E Brown
Prior improvements in multiple myeloma (MM) survival were not fully observed in racial and ethnic minorities and older individuals. We hypothesized that improvements in MM management in recent years have reduced these disparities. We used the Surveillance, Epidemiology, and End Results registries to calculate the incidence and relative survival rates (RSRs) of MM in the United States for patients diagnosed from 1993 to 1997 (prethalidomide), 1998 to 2002 (introduction of thalidomide), 2003 to 2007 (bortezomib and lenalidomide), and 2008 to 2012 (upfront bortezomib and lenalidomide, early availability of carfilzomib and pomalidomide)...
January 10, 2017: Blood Advances
https://www.readbyqxmd.com/read/29291352/recurrent-ecsit-mutation-encoding-v140a-triggers-hyperinflammation-and-promotes-hemophagocytic-syndrome-in-extranodal-nk-t-cell-lymphoma
#9
Haijun Wen, Huajuan Ma, Qichun Cai, Suxia Lin, Xinxing Lei, Bin He, Sijin Wu, Zifeng Wang, Yan Gao, Wensheng Liu, Weiping Liu, Qian Tao, Zijie Long, Min Yan, Dali Li, Keith W Kelley, Yongliang Yang, Huiqiang Huang, Quentin Liu
Hemophagocytic syndrome (HPS) is a fatal hyperinflammatory disease with a poorly understood mechanism that occurs most frequently in extranodal natural killer/T cell lymphoma (ENKTL). Through exome sequencing of ENKTL tumor-normal samples, we have identified a hotspot mutation (c.419T>C) in the evolutionarily conserved signaling intermediate in Toll pathway (ECSIT) gene, encoding a V140A variant of ECSIT. ECSIT-V140A activated NF-κB more potently than the wild-type protein owing to its increased affinity for the S100A8 and S100A9 heterodimer, which promotes NADPH oxidase activity...
January 1, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29285050/thalidomide-and-its-analogues-a-review-of-the-potential-for-immunomodulation-of-fibrosis-diseases-and-opthalmopathy
#10
Ting Liu, Feng Guo, Xiaomin Zhu, Xiangge He, Lin Xie
The US Food and Drug Administration approved thalidomide and its analogues for the treatment of erythema nodosum leprosum, in spite of the notoriety of reports of severe birth defects in the middle of the last century. As immunomodulatory drugs, thalidomide and its analogues have been used to effectively treat various diseases. In the present review, preclinical data about the effects of thalidomide and its analogues on the immune system are integrated, including the effects of cytokines on transdifferentiation, the anti-inflammatory effect, immune cell function regulation and angiogenesis...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29251720/pharmacological-perturbation-of-cdk9-using-selective-cdk9-inhibition-or-degradation
#11
Calla M Olson, Baishan Jiang, Michael A Erb, Yanke Liang, Zainab M Doctor, Zinan Zhang, Tinghu Zhang, Nicholas Kwiatkowski, Myriam Boukhali, Jennifer L Green, Wilhelm Haas, Tyzoon Nomanbhoy, Eric S Fischer, Richard A Young, James E Bradner, Georg E Winter, Nathanael S Gray
Cyclin-dependent kinase 9 (CDK9), an important regulator of transcriptional elongation, is a promising target for cancer therapy, particularly for cancers driven by transcriptional dysregulation. We characterized NVP-2, a selective ATP-competitive CDK9 inhibitor, and THAL-SNS-032, a selective CDK9 degrader consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). To our surprise, THAL-SNS-032 induced rapid degradation of CDK9 without affecting the levels of other SNS-032 targets...
December 18, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/29248988/pharmacovigilance-in-developing-countries-part-i-importance-and-challenges
#12
Shaimaa Elshafie, Iman Zaghloul, Anne Marie Roberti
The thalidomide disaster was the significant historical event that acted as a catalyst for pharmacovigilance activity. Following this event developed countries initiated drug monitoring systems that evolved and now extend their scope to broader drug-related safety issues; however, this was not the case in developing countries. Pharmacovigilance is still a relatively new concept with low priority in developing countries although various issues are raising concerns that magnify the need for systems to monitor post marketing drug safety in these countries...
December 16, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29241368/gastrointestinal-perforation-in-light-chain-amyloidosis-in-the-era-of-novel-agent-therapy-a-case-series-and-review-of-the-literature
#13
Adir Shaulov, Irit Avivi, Yael Cohen, Adrian Duek, Merav Leiba, Moshe E Gatt
Gastrointestinal (GI) perforation is remarkably rare in patients with light chain (AL) amyloidosis and has not yet been reported in patients with AL amyloidosis treated with novel agents. Only 24 cases of GI perforation have previously been reported in the setting of AL amyloidosis of which 15 had available information in English. All 15 did not receive novel agent therapy and six died early after experiencing GI perforation. This study reports the characteristics and outcome of AL patients that developed GI perforation in the era of novel agent treatment...
December 14, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/29238068/microrna-105-is-involved-in-tnf-%C3%AE-related-tumor-microenvironment-enhanced-colorectal-cancer-progression
#14
Zetao Shen, Rui Zhou, Chen Liu, Yaofeng Wang, Wanqi Zhan, Ziyun Shao, Jian Liu, Feifei Zhang, Lijun Xu, Xinying Zhou, Lu Qi, Feng Bo, Yanqing Ding, Liang Zhao
TNF-α is a central proinflammatory cytokine contributing to malignant tumor progression in tumor microenvironment. In this study, we found the upregulation of miR-105 in colorectal cancer was associated with aggressive phenotype, and the enhanced expression of miR-105 was required for TNF-α-induced epithelial-mesenchymal transition (EMT). The expression of miR-105 was remarkably stimulated by TNF-α in a time-dependent manner using real-time qPCR analysis. Inhibition of miR-105 remarkably weakened the aggressive effects of TNF-α through preventing the activation of NF-κB signaling and the initiation of EMT...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29232284/thalidomide-as-a-cough-suppressant-in-idiopathic-pulmonary-fibrosis
#15
Rebecca Haraf, Arjan S Flora, Ragheb Assaly
No abstract text is available yet for this article.
November 22, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29226500/anti-inflammatory-effects-of-propranolol-in-the-temporomandibular-joint-of-female-rats-and-its-contribution-to-antinociceptive-action
#16
F B Zanelatto, E V Dias, J M Teixeira, C R Sartori, C A Parada, C H Tambeli
BACKGROUND: β-Blockers reduce temporomandibular joint (TMJ) pain. We asked whether they also reduce TMJ inflammation and, if so, whether this anti-inflammatory effect contributes to its analgesic action. METHODS: We measured many parameters of the inflammatory response after co-administration of the β-blocker propranolol with the inflammatory agent carrageenan in the TMJ of female rats. We also hypothesized that the activation of β-adrenoceptors in the TMJ induces nociception mediated, at least in part, by the inflammatory response...
December 11, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29223784/thalidomide-attenuates-development-of-morphine-dependence-in-mice-by-inhibiting-pi3k-akt-and-nitric-oxide-signaling-pathways
#17
Muhammad Imran Khan, Majid Momeny, Sattar Ostadhadi, Samane Jahanabadi, Shahram Ejtemaee-Mehr, Bilqees Sameem, Ghazaleh Zarrinrad, Ahmad Reza Dehpour
Morphine dependence and the subsequent withdrawal syndrome restrict its clinical use in management of chronic pain. The precise mechanism for the development of dependence is still elusive. Thalidomide is a glutamic acid derivative, recently has been reconsidered for its clinical use due to elucidation of different clinical effects. Phosphoinositide 3-kinase (PI3K) is an intracellular transducer enzyme which activates Akt which in turns increases the level of nitric oxide. It is well established that elevated levels of nitric oxide has a pivotal role in the development of morphine dependence...
December 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29222258/fixed-duration-vs-continuous-therapy-in-multiple-myeloma
#18
REVIEW
Heinz Ludwig, Niklas Zojer
The introduction of new drugs with less severe toxicity profiles than those of conventional antimyeloma agents allowed the evaluation of continuous therapy compared with fixed duration therapy. In transplant-eligible patients, consolidation therapy with bortezomib or bortezomib-based regimens showed significant progression-free survival (PFS) benefit in cytogenetic standard-risk patients and to a lesser extent, high-risk patients. Continuous therapy with lenalidomide maintenance treatment after autologous stem cell transplantation resulted in a significant survival gain...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29219049/role-of-mitochondrial-mechanism-in-chemotherapy-induced-peripheral-neuropathy
#19
Mohammad Waseem, Pooja Kaushik, Heena Tabassum, Suhel Parvez
BACKGROUND: Even though chemotherapeutic regimens shows considerable importance, it may cause progressive, continuing and sometimes irreversible peripheral neuropathy. Chemotherapy induced peripheral neuropathy (CIPN) comprises of sensory abnormalities that are most distress issues. The mechanism associated with CIPN pathogenesis is not completely revealed and is treatment is still questionable. The purpose of this review was to investigate the role of mitochondria in CIPN. METHODS: This review is literature based that describes the mitochondrial mechanism underlying CIPN and the neuropathic complications associated with different antineoplastic agents...
December 7, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29217895/efficacy-of-thalidomide-for-recurrent-gastrointestinal-bleeding-due-to-angiodysplasias-in-a-hemodialysis-patient
#20
M Tamzaourte, Y Zajjari
No abstract text is available yet for this article.
November 2017: Indian Journal of Nephrology
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