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Complicated skin and skin structure infection

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https://www.readbyqxmd.com/read/27911406/ultrasound-guided-botulinum-toxin-a-injections-a-method-of-treating-sialorrhea
#1
Pierangelo Barbero, Marco Busso, Carlo Alberto Artusi, Stefania De Mercanti, Marco Tinivella, Andrea Veltri, Luca Durelli, Marinella Clerico
Neurological diseases can be complicated by sialorrhea, an excessive flow of saliva. Patients suffering from moderate to severe sialorrhea have an impaired quality of life, often worsened by correlated complications such as aspiration pneumonia, oral infections, dental caries, and maceration of the skin. Diverse therapeutic approaches have been proposed for the treatment of sialorrhea, including surgery and the use of anticholinergic agents, with limited results and the possible occurrence of serious adverse events...
November 9, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27885468/staphylococcus-lugdunensis-infections-filling-in-the-gaps-a-3-year-retrospective-review-from-a-comprehensive-cancer-center
#2
Lior Nesher, Jeffery Tarrand, Roy F Chemaly, Kenneth Vi Rolston
OBJECTIVE: Staphylococcus lugdunensis is considered to be more aggressive than other coagulase-negative staphylococci (CoNS). There are gaps in knowledge regarding the importance of isolating S. lugdunensis from different sources and in different patient subsets. Our objective was to describe the spectrum, clinical manifestations, and outcomes of infections caused by S. lugdunensis in patients with cancer. METHODS: A retrospective review of all cancer patients from whom S...
November 24, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27846299/hyperglycemia-induces-skin-barrier-dysfunctions-with-impairment-of-epidermal-integrity-in-non-wounded-skin-of-type-1-diabetic-mice
#3
Junko Okano, Hideto Kojima, Miwako Katagi, Takahiko Nakagawa, Yuki Nakae, Tomoya Terashima, Takeshi Kurakane, Mamoru Kubota, Hiroshi Maegawa, Jun Udagawa
Diabetes causes skin complications, including xerosis and foot ulcers. Ulcers complicated by infections exacerbate skin conditions, and in severe cases, limb/toe amputations are required to prevent the development of sepsis. Here, we hypothesize that hyperglycemia induces skin barrier dysfunction with alterations of epidermal integrity. The effects of hyperglycemia on the epidermis were examined in streptozotocin-induced diabetic mice with/without insulin therapy. The results showed that dye leakages were prominent, and transepidermal water loss after tape stripping was exacerbated in diabetic mice...
2016: PloS One
https://www.readbyqxmd.com/read/27819873/hydrophilic-polymer-associated-ischemic-enterocolitis
#4
Jesus A Chavez, Wei Chen, Wendy L Frankel, Christina A Arnold
Hydrophilic polymer coating of medical devices serves to lubricate the device and prevent device-related complications. The coating can be mechanically disrupted and result in downstream injury via presumed thromboembolism. This process has been reported in the brain, heart, lung, and skin, and has been replicated through animal studies and in vitro histologic processing of the polymer coating. We report the first description of hydrophilic polymer-associated ischemic enterocolitis in a series of 7 specimens (small bowel=2, colon=4, aortic thrombus=1) from 3 patients...
November 4, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27795423/dysregulated-glycoprotein-b-mediated-cell-cell-fusion-disrupts-varicella-zoster-virus-and-host-gene-transcription-during-infection
#5
Stefan L Oliver, Edward Yang, Ann M Arvin
: The highly conserved herpesvirus glycoprotein complex, gB/gH-gL, mediates membrane fusion during virion entry and cell-cell fusion. Varicella-zoster virus (VZV) characteristically forms multi-nucleated cells, or syncytia, during the infection of human tissues but little is known about this process. The cytoplasmic domain of VZV gB (gBcyt) has been implicated in cell-cell fusion regulation because a gB[Y881F] substitution causes hyperfusion. The gBcyt regulation is necessary for VZV pathogenesis as the hyperfusogenic mutant gB[Y881F] is severely attenuated in human skin xenografts...
October 26, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27721793/systematic-review-and-meta-analysis-of-the-efficacy-and-safety-of-telavancin-for-treatment-of-infectious-disease-are-we-clearer
#6
Junlan Chuan, Yuan Zhang, Xia He, Yuxuan Zhu, Lei Zhong, Dongke Yu, Hongtao Xiao
Objective: Telavancin is approved to treat complicated skin and skin structure infections, hospital-acquired, and ventilator-associated bacterial pneumonia caused by Staphylococcus aureus. A previous meta-analysis of randomized controlled trials suggested that it might be an alternative to vancomycin in cases of difficult-to-treat meticillin-resistant S. aureus infections. We did a meta-analysis including one new trial to access the efficacy and safety of telavancin. Methods: We searched PubMed, Cochrane Central Register of Controlled Trials, EMBASE and ClinicalTrials...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27699220/biofilm-in-group-a-streptococcal-necrotizing-soft-tissue-infections
#7
Nikolai Siemens, Bhavya Chakrakodi, Srikanth Mairpady Shambat, Marina Morgan, Helena Bergsten, Ole Hyldegaard, Steinar Skrede, Per Arnell, Martin B Madsen, Linda Johansson, Julius Juarez, Lidija Bosnjak, Matthias Mörgelin, Mattias Svensson, Anna Norrby-Teglund
Necrotizing fasciitis caused by group A streptococcus (GAS) is a life-threatening, rapidly progressing infection. At present, biofilm is not recognized as a potential problem in GAS necrotizing soft tissue infections (NSTI), as it is typically linked to chronic infections or associated with foreign devices. Here, we present a case of a previously healthy male presenting with NSTI caused by GAS. The infection persisted over 24 days, and the surgeon documented the presence of a "thick layer biofilm" in the fascia...
July 7, 2016: JCI Insight
https://www.readbyqxmd.com/read/27690689/ceftobiprole-medocaril-bal-5788-for-the-treatment-of-complicated-skin-infections
#8
Amelia Deitchman, Daniel de Jong, April Barbour, Hartmut Derendorf
With resistance of S. aureus, the most prevalent identified pathogen in skin and soft tissue infections, on the rise, the need for safe, effective, and well-tolerated antibiotics is crucial. Ceftobiprole medocaril (BAL-5788), ceftobiprole's parenteral prodrug, is a bactericidal cephalosporin with broad Gram-positive and Gram-negative activity that has shown to be well-tolerated and noninferior to vancomycin and vancomycin plus ceftazidime in the treatment of MRSA complicated skin and skin structure infections (cSSSIs) in clinical trials...
October 2, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27689051/clinical-experiences-with-the-scapular-fascial-free-flap
#9
Il Ho Park, Chul Hoon Chung, Yong Joon Chang, Jae Hyun Kim
BACKGROUND: The goal of reconstruction is to provide coverage of exposed vital structures with well-vascularized tissue for optimal restoration of form and function. Here, we present our clinical experience with the use of the scapular fascial free flap to correct facial asymmetry and to reconstruct soft tissue defects of the extremities. METHODS: We used a scapular fascial free flap in 12 cases for soft tissue coverage of the extremities or facial soft tissue augmentation...
September 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27477938/the-role-of-osmotic-self-inflatable-tissue-expanders-in-intestinal-transplant-candidates
#10
REVIEW
Laurens J Ceulemans, Nathalie P Deferm, Marc Miserez, Francesca Maione, Diethard Monbaliu, Jacques Pirenne
Intestinal transplantation (ITx) is often associated with decreased abdominal domain, rendering abdominal closure difficult. Pre-transplant placement of tissue expanders (TE) can overcome this challenge; however it can be associated with life-threatening complications. This review aimed to comprehensively summarize all available literature on TE in ITx candidates and include the technical details of osmotic, self-inflatable TE -a technique undescribed before. PubMed, EMBASE and CCTR were searched until April 30, 2016...
October 2016: Transplantation Reviews
https://www.readbyqxmd.com/read/27469981/discovery-pharmacology-and-clinical-profile-of-omadacycline-a-novel-aminomethylcycline-antibiotic
#11
S Ken Tanaka, Judith Steenbergen, Stephen Villano
Omadacycline is novel, aminomethyl tetracycline antibiotic being developed for oral and intravenous (IV) administration for the treatment of community-acquired bacterial infections. Omadacycline is characterized by an aminomethyl substituent at the C9 position of the core 6-member ring. Modifications at this position result in an improved spectrum of antimicrobial activity by overcoming resistance known to affect older generation tetracyclines via ribosomal protection proteins and efflux pump mechanisms. In vitro, omadacycline has activity against Gram-positive and Gram-negative aerobes, anaerobes, and atypical pathogens including Legionella and Chlamydia spp...
July 18, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27411685/-treatment-of-dermatoses-significance-and-use-of-glucocorticoids-in-fixed-combination-with-antifungals
#12
REVIEW
P Mayser
Treating eczema with fungal and/or bacterial superinfections or superficial mycoses are a common problem in daily practice. A fungal superinfection as a consequence of a diminished skin barrier might complicate the course of eczema. In addition, in an inflammatory superficial mycotic infection a delayed-type hypersensitivity reaction may result in healing of the lesion, but might also be responsible for irreversible damage of epidermal structures. An example is permanent hair loss by scarring alopecia in the context of inflammatory tinea capitis...
September 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27366592/regenerative-medicine-charting-a-new-course-in-wound-healing
#13
Geoffrey C Gurtner, Mary Ann Chapman
Significance: Chronic wounds are a prevalent and costly problem in the United States. Improved treatments are needed to heal these wounds and prevent serious complications such as infection and amputation. Recent Advances: In wound healing, as in other areas of medicine, technologies that have the potential to regenerate as opposed to repair tissue are gaining ground. These include customizable nanofiber matrices incorporating novel materials; a variety of autologous and allogeneic cell types at various stages of differentiation (e...
July 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27336452/update-imaging-of-lower-extremity-infection
#14
Kassel Wai Kan Tsang, William B Morrison
Pedal infection is a difficult diagnostic problem for clinicians and radiologists alike, especially in patients with diabetes. Vascular and neuropathic disease complicates the clinical picture and imaging appearance. Radiographs are usually the first examination ordered, offering an excellent overview of previous surgery, structural deformities, and neuropathic joint disease. Ultrasound and computed tomography are occasionally useful to answer specific questions. Scintigraphy has become less popular because MRI provides high sensitivity and specificity as well as detailed anatomical information...
April 2016: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/27326940/acute-vascular-complications-flap-necrosis-and-congestion-with-one-stage-and-two-stage-distally-based-sural-flap-for-wound-coverage-around-the-ankle
#15
N M Yusof, A S Fadzli, W S Azman, M A Azril
INTRODUCTION: The understanding of the skin's vascular anatomy has improved in the last decade. It has lead to technique modification such as the staged procedure in performing sural flaps and improvement in the flap survival rate. The aim of this study was to evaluate the acute vascular complications (flap necrosis or congestion) of 29 patients who underwent distal base sural flap for coverage of wound around the ankle. METHODS: Twenty-four males and five females with a mean age of 37...
April 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/27218253/-pelvic-limb-damage-control-following-a-complex-foot-injury-case-report
#16
D Velázquez-Vélez, N Durán-Martínez, J A Peñafort-García, A Romero-Peña
More than 20% of the tarsometatarsal joint injuries (Lisfranc injuries) occur during motor vehicle accidents. This kind of trauma is infrequent and in 50% of cases closed reduction is used. A 18 year-old male patient sustained a high-energy trauma resulting in a Gustilo and Anderson III B open Lisfranc fracture dislocation of the left foot. Surgical debridement, open reduction and internal fixation, and immediate skin coverage were performed. The secondary complication rate may decrease with stringent treatment adherence and proper care of severe orthopedic injuries...
September 2015: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/27189769/outcomes-after-retroflexed-gracilis-muscle-flap-for-vascular-infections-in-the-groin
#17
Ahsan T Ali, Mario Rueda, Sarasijhaa Desikan, Mohammed M Moursi, Ruosu An, Horace Spencer, Steven Rueda, John F Eidt
OBJECTIVE: Multiple catheterizations and procedures on the femoral arteries can increase the risk of infection and eventual destruction of the overlying skin and subcutaneous tissue. Without adequate tissue coverage, vascular structures are exposed and, thus, vulnerable to disruption. This can lead to loss of limb and/or life and carries a significant mortality. We hypothesized that gracilis muscle flap (GMF) was a reliable adjunct in providing healthy tissue coverage for a complex surgical problem...
May 14, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27167417/-effect-of-negative-pressure-wound-therapy-on-infectious-complications-in-grade-iii-open-fractures
#18
M Krtička, D Ira, V Nekuda, J Švancara, M Mašek
UNLABELLED: PURPOSE OF THE STUDY Grade III open fractures are associated with infectious complications in 25-66% of injuries. Negative pressure wound therapy (NPWT) applied to an injured soft tissue coverage provides an impermeable barrier between the injured structures and the external environment, in addition to early secretion draining and a positive effect on the site of application. All this also prevents secondary bacterial contamination. The objective of the study was to compare the results of treatment methods in view of infectious complications in patients with soft tissue injury in grade-III open fractures managed either by NPWT and primary closure or by covering with combined dressing fabric (COM) in combination with continual wound lavage...
2016: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/27158752/pharmacodynamics-pharmacokinetics-and-clinical-efficacy-of-telavancin-in-the-treatment-of-pneumonia
#19
Liapikou Adamantia, Torres Antoni
INTRODUCTION: Telavancin is a novel lipoglycopeptide derivative of vancomycin that has activity against Gram-positive aerobic and anerobic bacteria, for the treatment of serious infections, including complicated skin and skin structure infections (cSSSI) and pneumonia. AREAS COVERED: This article was compiled through searches on telavancin up to December 2015 in the PubMed and the clinicaltrials.gov databases; the FDA and European Medicine Agency (EMA) websites...
July 2016: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/27084183/acute-bacterial-skin-and-skin-structure-infections-in-internal-medicine-wards-old-and-new-drugs
#20
REVIEW
Marco Falcone, Ercole Concia, Massimo Giusti, Antonino Mazzone, Claudio Santini, Stefania Stefani, Francesco Violi
Skin and soft tissue infections (SSTIs) are a common cause of hospital admission among elderly patients, and traditionally have been divided into complicated and uncomplicated SSTIs. In 2010, the FDA provided a new classification of these infections, and a new category of disease, named acute bacterial skin and skin structure infections (ABSSSIs), has been proposed as an independent clinical entity. ABSSSIs include three entities: cellulitis and erysipelas, wound infections, and major cutaneous abscesses This paper revises the epidemiology of SSTIs and ABSSSIs with regard to etiologies, diagnostic techniques, and clinical presentation in the hospital settings...
August 2016: Internal and Emergency Medicine
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