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Complicated skin and skin structure infection

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https://www.readbyqxmd.com/read/29730514/breastfeeding-difficulty-after-polyacrylamide-hydrogel-paag-mediated-breast-augmentation
#1
Rami Mossad Ibrahim, Elisabeth Lauritzen, Caspar Weel Krammer
INTRODUCTION: Breast augmentation using polyacrylamide hydrogel (PAAG) has been routinely used in the past as a minimal invasive procedure. However, several patients undergoing this procedure have started to report complications. We report a case of breast augmentation using PAAG leading to a delayed infection and breastfeeding complication. CLINICAL CASE: A 36-year-old Danish female who was treated with PAAG fifteen years earlier, presented with difficulty in breastfeeding and fistulation...
April 30, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29657907/comparing-surgical-site-infection-and-scar-cosmesis-between-conventional-linear-skin-closure-versus-purse-string-skin-closure-in-stoma-reversal-a-randomized-controlled-trial
#2
Sathasivam Sureshkumar, Kunnathoor Jubel, Manwar S Ali, Chellappa Vijayakumar, Anandhi Amaranathan, Sudharsanan Sundaramoorthy, Chinnakali Palanivel
Introduction Stoma closure is one of the most frequently performed surgeries. The common complications are surgical site infection (SSI) and poor scar cosmesis. Purse-string sutures are expected to have less incidence of SSI due to the free drainage of secretions from the wound and possibly the early detection of a wound infection. Compared to the conventional linear closure, the purse-string closure technique is expected to have less wound infection, improved scar cosmesis, and good patient satisfaction because of a smaller size scar...
February 11, 2018: Curēus
https://www.readbyqxmd.com/read/29623187/moxifloxacin-induced-tinnitus-in-an-older-adult
#3
Amber Onoh, Sunny A Linnebur, Danielle R Fixen
An increased risk of bacterial resistance toward fluoroquinolones and the increased risk of disabling and serious adverse effects prompted the US Food and Drug Administration to recommend limiting fluoroquinolone use to the treatment of community-acquired pneumonia, skin and skin-structure infections, bacterial sinusitis, plague, chronic bronchitis exacerbations, and complicated intra-abdominal infections. We report a case of moxifloxacin-induced tinnitus in an older adult prescribed oral moxifloxacin 400 mg for 5 days for the treatment of acute diverticulitis, due to allergies to nonfluoroquinolone preferred agents...
April 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29573163/evaluation-of-the-temporary-effect-of-physical-vapor-deposition-silver-coating-on-resistance-to-infection-in-transdermal-skin-and-bone-integrated-pylon-with-deep-porosity
#4
Maxim A Shevtsov, Natalia M Yudintceva, Miralda I Blinova, Irina V Voronkina, Dmitriy N Suslov, Oleg V Galibin, Dmitriy V Gavrilov, Michael Akkaoui, Grigoriy Raykhtsaum, Andrey V Albul, Emil Pitkin, Mark Pitkin
Periprosthetic infection via skin-implant interface is a leading cause of failures and revisions in direct skeletal attachment of limb prostheses. Implants with deep porosity fabricated with skin and bone integrated pylons (SBIP) technology allow for skin ingrowth through the implant's structure creating natural barrier against infection. However, until the skin cells remodel in all pores of the implant, additional care is required to prevent from entering bacteria to the still nonoccupied pores. Temporary silver coating was evaluated in this work as a means to provide protection from infection immediately after implantation followed by dissolution of silver layer in few weeks...
March 23, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29553975/expanded-paramedian-forehead-flaps-for-nasal-defects-beyond-aesthetic-subunits
#5
Hai-Chun Ni, Jie-Cong Wang, Jia-Ming Sun, Neng-Qiang Guo
BACKGROUND: Reconstruction of nasal tip defects presents a significant challenge for plastic surgeons. The form, function, and aesthetic appeal of all nasal subunits must be addressed. The expanded paramedian forehead flap is a good choice for nasal reconstruction, providing similar texture, structure, and skin color, and high reliability. This article discusses the authors' modification of the expanded paramedian forehead flap in reconstructing defects on or around the nasal tip. METHODS: Twenty-two patients with nasal defects located on or around the nasal tip were treated in our institution...
March 16, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29423421/an-updated-review-of-iclaprim-a-potent-and-rapidly-bactericidal-antibiotic-for-the-treatment-of-skin-and-skin-structure-infections-and-nosocomial-pneumonia-caused-by-gram-positive-including-multidrug-resistant-bacteria
#6
REVIEW
David B Huang, Catherine D Strader, James S MacDonald, Mark VanArendonk, Richard Peck, Thomas Holland
New antibiotics are needed because of the increased morbidity and mortality associated with multidrug-resistant bacteria. Iclaprim, a bacterial dihydrofolate reductase inhibitor, not currently approved, is being studied for the treatment of skin infections and nosocomial pneumonia caused by Gram-positve bacteria, including multidrug-resistant bacteria. Iclaprim showed noninferiority at -10% to linezolid in 1 of 2 phase 3 studies for the treatment of complicated skin and skin structure infections with a weight-based dose (0...
February 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29383415/autologous-fibroblast-seeded-amnion-for-reconstruction-of-neo-vagina-in-male-to-female-reassignment-surgery
#7
Kamal Seyed-Forootan, Hamid Karimi, Nazilla-Sadat Seyed-Forootan
BACKGROUND: Plastic surgeons have used several methods for the construction of neo-vaginas, including the utilization of penile skin, free skin grafts, small bowel or recto-sigmoid grafts, an amnion graft, and cultured cells. PURPOSE: The aim of this study is to compare the results of amnion grafts with amnion seeded with autograft fibroblasts. MATERIALS AND METHODS: Over 8 years, we compared the results of 24 male-to-female transsexual patients retrospectively based on their complications and levels of satisfaction...
April 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29320640/syme-amputation-a-systematic-review
#8
Rudwina Braaksma, Pieter U Dijkstra, Jan H B Geertzen
BACKGROUND: In the decision-making process toward an amputation of the lower extremity, knowledge about patient-related outcomes after amputation and rehabilitation is important. We have not found a systematic review that provides this knowledge for Syme amputation. The aim of this study was to present an overview of outcomes after a Syme amputation grouped according to the International Classification of Functioning, Disability and Health (ICF) model, focusing on body structures and functions, activities, and participation...
March 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29284898/complications-after-ileal-urinary-derivations
#9
Alden Prcic, Edin Begic
Introduction: The aim of the study was to determine the most frequent early and late complications in different types of ileal urinary diversions. Patients and methods: The study was conducted in a five-year period, on 106 patients who were diagnosed with invasive urinary bladder cancer and who had indication for radical cystectomy with one of the investigated types of urine derivation. They were divided into 2 groups, based on the type of ileal urinary diversions...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29222405/multiple-weekly-dalbavancin-dosing-for-the-treatment-of-native-vertebral-osteomyelitis-caused-by-methicillin-resistant-staphylococcus-aureus-a-case-report
#10
Thamer A Almangour, Valerie Fletcher, Mohammed Alessa, Abdullah A Alhifany, Deanne Tabb
BACKGROUND Native vertebral osteomyelitis (NVO) is a common form of hematogenous osteomyelitis, with Staphylococcus aureus (S. aureus) being the most commonly isolated organism. Dalbavancin is approved by the US Food and Drug Administration (FDA) for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and has a sufficiently promising pharmacokinetic and pharmacodynamic profile to be considered for the treatment of vertebral osteomyelitis. We describe here what is probably the first reported case of using multiple weekly dalbavancin to treat a complicated methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and vertebral osteomyelitis...
December 9, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29180276/dalbavancin-in-the-treatment-of-different-gram-positive-infections-a-real-life-experience
#11
Emilio Bouza, Maricela Valerio, Alex Soriano, Laura Morata, Enrique García Carus, Carmen Rodríguez-González, Ma Carmen Hidalgo-Tenorio, Antonio Plata, Patricia Muñoz, Antonio Vena
Dalbavancin is a lipoglycopeptide with a very prolonged half-life enabling treatment with a single intravenous administration that has been approved to treat complicated skin and soft-tissue infections. Information on the efficacy and safety of dalbavancin in other situations is very scarce. This retrospective study included adult patients who received at least one dose of dalbavancin between 2016 and 2017 in 29 institutions in Spain. The primary objective was to report the use of dalbavancin in clinical practice, including its efficacy and tolerability...
April 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29173791/new-antimicrobial-agents-for-the-treatment-of-staphylococcal-infections-in-children
#12
REVIEW
Roopali Sharma, Densley Francois, Margaret R Hammerschlag
Several new antimicrobial agents-daptomycin, ceftaroline, telavancin, dalbavancin, and-tedizolid have been approved for the treatment of staphylococcal infections, including methicillin-resistant Staphylococcus aureus (MRSA), in adults. Ceftaroline and daptomycin have been approved by the US Food and Drug Administration for use in children. Ceftaroline, a beta-lactam antibiotic with activity against MRSA, has been approved for treatment of community-acquired bacterial pneumonia and complicated skin and skin structure infections...
December 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/29151421/-disposable-nursing-applicator-pocket-of-indwelling-central-venous-catheter
#13
Congli Wei, Chunyuan Ma
Catheter related infection is the most common complication of central venous catheter, which pathogen mainly originate from the pipe joint and the skin around puncture site. How to prevent catheter infection is an important issue in clinical nursing. The utility model disclosed a "disposable nursing applicator-pocket of indwelling central venous catheter", which is mainly used for the fixation and the protection. The main structure consists of two parts, one is medical applicator to protect the skin around puncture site, and the other is gauze pocket to protect the catheter external connector...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29138583/efficacy-of-intravenous-tigecycline-in-patients-with-acinetobacter-complex-infections-results-from-14-phase-iii-and-phase-iv-clinical-trials
#14
Hal Tucker, Michele Wible, Ashesh Gandhi, Alvaro Quintana
Background: Acinetobacter infections, especially multidrug-resistant (MDR) Acinetobacter infections, are a global health problem. This study aimed to describe clinical outcomes in patients with confirmed Acinetobacter spp. isolates who were treated with tigecycline in randomized clinical trials. Materials and methods: Data from 14 multinational, randomized (open-label or double-blind), and active-controlled (except one) Phase III and IV studies were analyzed using descriptive statistics...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29133566/pharmacokinetic-and-pharmacodynamic-analyses-to-determine-the-optimal-fixed-dosing-regimen-of-iclaprim-for-treatment-of-patients-with-serious-infections-caused-by-gram-positive-pathogens
#15
Thomas P Lodise, John Bosso, Colleen Kelly, Paul J Williams, James R Lane, David B Huang
Iclaprim is a bacterial dihydrofolate reductase inhibitor that is currently being evaluated in two phase 3 trials for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSI). Prior animal infection model studies suggest that the pharmacokinetic/pharmacodynamic (PK/PD) drivers for efficacy are area under the concentration-time curve from 0 to 24 h at steady state (AUC0-24ss ), AUC/MIC, and time above the MIC during the dosing interval ( T > MIC), while QTc prolongation was associated with the maximal concentration at steady state ( C maxss ) in a thorough QTc phase 1 study...
February 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29121395/multiple-dose-oritavancin-evaluation-in-a-retrospective-cohort-of-patients-with-complicated-infections
#16
Lucas T Schulz, Emily Dworkin, Jennifer Dela-Pena, Warren E Rose
OBJECTIVE: Oritavancin is a lipoglycopeptide antibiotic approved for use in acute bacterial skin and skin structure infections as a single 1200-mg parenteral dose. Because of oritavancin's long half-life and broad gram-positive activity, interest in its use for other infections is high. METHODS: This study is a retrospective cohort evaluation of patients receiving oritavancin at a single academic medical center. All patients receiving more than one dose of oritavancin were included...
January 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29098406/molecular-characterization-and-bioactivity-evaluation-of-two-novel-bombinin-peptides-from-the-skin-secretion-of-oriental-fire-bellied-toad-bombina-orientalis
#17
Xin Peng, Chang Zhou, Xuan Hou, Yao Liu, Zhengming Wang, Xiaolin Peng, Zhe Zhang, Ran Wang, Dexin Kong
Following the exploration of biochemicals in amphibian defensive skin secretion, great attention has been focused on the novel bioactive peptides with unique molecular structures and complicated features and functions. In this study, the skin secretion of Oriental fire-bellied toad, Bombina orientalis, was acquired to search peptides with therapeutic potential. Using "shotgun" cloning technique, a full-length peptide precursor co-encoding two novel bombinin peptides was cloned from the skin secretion-derived cDNA library of B...
February 2018: Amino Acids
https://www.readbyqxmd.com/read/29059358/daptomycin
#18
Mohsen Heidary, Azar Dohkt Khosravi, Saeed Khoshnood, Mohammad Javad Nasiri, Saleh Soleimani, Mehdi Goudarzi
Daptomycin is a cyclic lipopeptide antibiotic used for the treatment of Gram-positive infections including complicated skin and skin structure infections, right-sided infective endocarditis, bacteraemia, meningitis, sepsis and urinary tract infections. Daptomycin has distinct mechanisms of action, disrupting multiple aspects of cell membrane function and inhibiting protein, DNA and RNA synthesis. Although daptomycin resistance in Gram-positive bacteria is uncommon, there are increasing reports of daptomycin resistance in Staphylococcus aureus, Enterococcus faecium and Enterococcus faecalis...
January 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29053675/transcanalicular-diode-laser-assisted-dacryocystorhinostomy-for-the-treatment-of-primary-acquired-nasolacrimal-duct-obstruction
#19
Joel M Mor, Yongwei Guo, Konrad R Koch, Ludwig M Heindl
Today's gold standard in the treatment of infrasaccal primary acquired nasolacrimal duct obstruction (PANDO) is external dacryocystorhinostomy (DCR), a relatively invasive procedure that can be performed after failure of recanalizing treatments. However, with progress in the field of diode laser technology, new approaches have emerged. Laser-assisted transcanalicular DCR with subsequent bicanalicular silicon intubation is a new option showing great promise as a viable minimally invasive procedure. Under permanent endoscopic visual control from the nasal cavity, a diode laser fiber is inserted into the lacrimal sac and laser energy is applied to create a bony ostium between the lacrimal sac and the nasal cavity...
October 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28959736/comparative-analysis-of-bacterial-community-composition-and-structure-in-clinically-symptomatic-and-asymptomatic-central-venous-catheters
#20
Franziska A Stressmann, Elodie Couve-Deacon, Delphine Chainier, Ashwini Chauhan, Aimee Wessel, Sylvaine Durand-Fontanier, Marie-Christine Escande, Irène Kriegel, Bruno Francois, Marie-Cécile Ploy, Christophe Beloin, Jean-Marc Ghigo
Totally implanted venous access ports (TIVAPs) are commonly used catheters for the management of acute or chronic pathologies. Although these devices improve health care, repeated use of this type of device for venous access over long periods of time is also associated with risk of colonization and infection by pathogenic bacteria, often originating from skin. However, although the skin microbiota is composed of both pathogenic and nonpathogenic bacteria, the extent and the consequences of TIVAP colonization by nonpathogenic bacteria have rarely been studied...
September 2017: MSphere
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